8 results on '"Wan, Peggy"'
Search Results
2. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- Author
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Conti, David V., primary, Darst, Burcu F., additional, Moss, Lilit C., additional, Saunders, Edward J., additional, Sheng, Xin, additional, Chou, Alisha, additional, Schumacher, Fredrick R., additional, Olama, Ali Amin Al, additional, Benlloch, Sara, additional, Dadaev, Tokhir, additional, Brook, Mark N., additional, Sahimi, Ali, additional, Hoffmann, Thomas J., additional, Takahashi, Atushi, additional, Matsuda, Koichi, additional, Momozawa, Yukihide, additional, Fujita, Masashi, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Wan, Peggy, additional, Le Marchand, Loic, additional, Wilkens, Lynne R., additional, Stevens, Victoria L., additional, Gapstur, Susan M., additional, Carter, Brian D., additional, Schleutker, Johanna, additional, Tammela, Teuvo L. J., additional, Sipeky, Csilla, additional, Auvinen, Anssi, additional, Giles, Graham G., additional, Southey, Melissa C., additional, MacInnis, Robert J., additional, Cybulski, Cezary, additional, Wokołorczyk, Dominika, additional, Lubiński, Jan, additional, Neal, David E., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Martin, Richard M., additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Weischer, Maren, additional, Bojesen, Stig E., additional, Røder, Martin Andreas, additional, Iversen, Peter, additional, Batra, Jyotsna, additional, Chambers, Suzanne, additional, Moya, Leire, additional, Horvath, Lisa, additional, Clements, Judith A., additional, Tilley, Wayne, additional, Risbridger, Gail P., additional, Gronberg, Henrik, additional, Aly, Markus, additional, Szulkin, Robert, additional, Eklund, Martin, additional, Nordström, Tobias, additional, Pashayan, Nora, additional, Dunning, Alison M., additional, Ghoussaini, Maya, additional, Travis, Ruth C., additional, Key, Tim J., additional, Riboli, Elio, additional, Park, Jong Y., additional, Sellers, Thomas A., additional, Lin, Hui-Yi, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Mucci, Lorelei A., additional, Giovannucci, Edward, additional, Lindstrom, Sara, additional, Kraft, Peter, additional, Hunter, David J., additional, Penney, Kathryn L., additional, Turman, Constance, additional, Tangen, Catherine M., additional, Goodman, Phyllis J., additional, Thompson, Ian M., additional, Hamilton, Robert J., additional, Fleshner, Neil E., additional, Finelli, Antonio, additional, Parent, Marie-Élise, additional, Stanford, Janet L., additional, Ostrander, Elaine A., additional, Geybels, Milan S., additional, Koutros, Stella, additional, Freeman, Laura E. Beane, additional, Stampfer, Meir, additional, Wolk, Alicja, additional, Håkansson, Niclas, additional, Andriole, Gerald L., additional, Hoover, Robert N., additional, Machiela, Mitchell J., additional, Sørensen, Karina Dalsgaard, additional, Borre, Michael, additional, Blot, William J., additional, Zheng, Wei, additional, Yeboah, Edward D., additional, Mensah, James E., additional, Lu, Yong-Jie, additional, Zhang, Hong-Wei, additional, Feng, Ninghan, additional, Mao, Xueying, additional, Wu, Yudong, additional, Zhao, Shan-Chao, additional, Sun, Zan, additional, Thibodeau, Stephen N., additional, McDonnell, Shannon K., additional, Schaid, Daniel J., additional, West, Catharine M. L., additional, Burnet, Neil, additional, Barnett, Gill, additional, Maier, Christiane, additional, Schnoeller, Thomas, additional, Luedeke, Manuel, additional, Kibel, Adam S., additional, Drake, Bettina F., additional, Cussenot, Olivier, additional, Cancel-Tassin, Géraldine, additional, Menegaux, Florence, additional, Truong, Thérèse, additional, Koudou, Yves Akoli, additional, John, Esther M., additional, Grindedal, Eli Marie, additional, Maehle, Lovise, additional, Khaw, Kay-Tee, additional, Ingles, Sue A., additional, Stern, Mariana C., additional, Vega, Ana, additional, Gómez-Caamaño, Antonio, additional, Fachal, Laura, additional, Rosenstein, Barry S., additional, Kerns, Sarah L., additional, Ostrer, Harry, additional, Teixeira, Manuel R., additional, Paulo, Paula, additional, Brandão, Andreia, additional, Watya, Stephen, additional, Lubwama, Alexander, additional, Bensen, Jeannette T., additional, Fontham, Elizabeth T. H., additional, Mohler, James, additional, Taylor, Jack A., additional, Kogevinas, Manolis, additional, Llorca, Javier, additional, Castaño-Vinyals, Gemma, additional, Cannon-Albright, Lisa, additional, Teerlink, Craig C., additional, Huff, Chad D., additional, Strom, Sara S., additional, Multigner, Luc, additional, Blanchet, Pascal, additional, Brureau, Laurent, additional, Kaneva, Radka, additional, Slavov, Chavdar, additional, Mitev, Vanio, additional, Leach, Robin J., additional, Weaver, Brandi, additional, Brenner, Hermann, additional, Cuk, Katarina, additional, Holleczek, Bernd, additional, Saum, Kai-Uwe, additional, Klein, Eric A., additional, Hsing, Ann W., additional, Kittles, Rick A., additional, Murphy, Adam B., additional, Logothetis, Christopher J., additional, Kim, Jeri, additional, Neuhausen, Susan L., additional, Steele, Linda, additional, Ding, Yuan Chun, additional, Isaacs, William B., additional, Nemesure, Barbara, additional, Hennis, Anselm J. M., additional, Carpten, John, additional, Pandha, Hardev, additional, Michael, Agnieszka, additional, De Ruyck, Kim, additional, De Meerleer, Gert, additional, Ost, Piet, additional, Xu, Jianfeng, additional, Razack, Azad, additional, Lim, Jasmine, additional, Teo, Soo-Hwang, additional, Newcomb, Lisa F., additional, Lin, Daniel W., additional, Fowke, Jay H., additional, Neslund-Dudas, Christine, additional, Rybicki, Benjamin A., additional, Gamulin, Marija, additional, Lessel, Davor, additional, Kulis, Tomislav, additional, Usmani, Nawaid, additional, Singhal, Sandeep, additional, Parliament, Matthew, additional, Claessens, Frank, additional, Joniau, Steven, additional, Van den Broeck, Thomas, additional, Gago-Dominguez, Manuela, additional, Castelao, Jose Esteban, additional, Martinez, Maria Elena, additional, Larkin, Samantha, additional, Townsend, Paul A., additional, Aukim-Hastie, Claire, additional, Bush, William S., additional, Aldrich, Melinda C., additional, Crawford, Dana C., additional, Srivastava, Shiv, additional, Cullen, Jennifer C., additional, Petrovics, Gyorgy, additional, Casey, Graham, additional, Roobol, Monique J., additional, Jenster, Guido, additional, van Schaik, Ron H. N., additional, Hu, Jennifer J., additional, Sanderson, Maureen, additional, Varma, Rohit, additional, McKean-Cowdin, Roberta, additional, Torres, Mina, additional, Mancuso, Nicholas, additional, Berndt, Sonja I., additional, Van Den Eeden, Stephen K., additional, Easton, Douglas F., additional, Chanock, Stephen J., additional, Cook, Michael B., additional, Wiklund, Fredrik, additional, Nakagawa, Hidewaki, additional, Witte, John S., additional, Eeles, Rosalind A., additional, Kote-Jarai, Zsofia, additional, and Haiman, Christopher A., additional
- Published
- 2021
- Full Text
- View/download PDF
3. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- Author
-
Conti, David V., primary, Darst, Burcu F., additional, Moss, Lilit C., additional, Saunders, Edward J., additional, Sheng, Xin, additional, Chou, Alisha, additional, Schumacher, Fredrick R., additional, Olama, Ali Amin Al, additional, Benlloch, Sara, additional, Dadaev, Tokhir, additional, Brook, Mark N., additional, Sahimi, Ali, additional, Hoffmann, Thomas J., additional, Takahashi, Atushi, additional, Matsuda, Koichi, additional, Momozawa, Yukihide, additional, Fujita, Masashi, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Wan, Peggy, additional, Le Marchand, Loic, additional, Wilkens, Lynne R., additional, Stevens, Victoria L., additional, Gapstur, Susan M., additional, Carter, Brian D., additional, Schleutker, Johanna, additional, Tammela, Teuvo L. J., additional, Sipeky, Csilla, additional, Auvinen, Anssi, additional, Giles, Graham G., additional, Southey, Melissa C., additional, MacInnis, Robert J., additional, Cybulski, Cezary, additional, Wokołorczyk, Dominika, additional, Lubiński, Jan, additional, Neal, David E., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Martin, Richard M., additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Weischer, Maren, additional, Bojesen, Stig E., additional, Røder, Martin Andreas, additional, Iversen, Peter, additional, Batra, Jyotsna, additional, Chambers, Suzanne, additional, Moya, Leire, additional, Horvath, Lisa, additional, Clements, Judith A., additional, Tilley, Wayne, additional, Risbridger, Gail P., additional, Gronberg, Henrik, additional, Aly, Markus, additional, Szulkin, Robert, additional, Eklund, Martin, additional, Nordström, Tobias, additional, Pashayan, Nora, additional, Dunning, Alison M., additional, Ghoussaini, Maya, additional, Travis, Ruth C., additional, Key, Tim J., additional, Riboli, Elio, additional, Park, Jong Y., additional, Sellers, Thomas A., additional, Lin, Hui-Yi, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Mucci, Lorelei A., additional, Giovannucci, Edward, additional, Lindstrom, Sara, additional, Kraft, Peter, additional, Hunter, David J., additional, Penney, Kathryn L., additional, Turman, Constance, additional, Tangen, Catherine M., additional, Goodman, Phyllis J., additional, Thompson, Ian M., additional, Hamilton, Robert J., additional, Fleshner, Neil E., additional, Finelli, Antonio, additional, Parent, Marie-Élise, additional, Stanford, Janet L., additional, Ostrander, Elaine A., additional, Geybels, Milan S., additional, Koutros, Stella, additional, Freeman, Laura E. Beane, additional, Stampfer, Meir, additional, Wolk, Alicja, additional, Håkansson, Niclas, additional, Andriole, Gerald L., additional, Hoover, Robert N., additional, Machiela, Mitchell J., additional, Sørensen, Karina Dalsgaard, additional, Borre, Michael, additional, Blot, William J., additional, Zheng, Wei, additional, Yeboah, Edward D., additional, Mensah, James E., additional, Lu, Yong-Jie, additional, Zhang, Hong-Wei, additional, Feng, Ninghan, additional, Mao, Xueying, additional, Wu, Yudong, additional, Zhao, Shan-Chao, additional, Sun, Zan, additional, Thibodeau, Stephen N., additional, McDonnell, Shannon K., additional, Schaid, Daniel J., additional, West, Catharine M. L., additional, Burnet, Neil, additional, Barnett, Gill, additional, Maier, Christiane, additional, Schnoeller, Thomas, additional, Luedeke, Manuel, additional, Kibel, Adam S., additional, Drake, Bettina F., additional, Cussenot, Olivier, additional, Cancel-Tassin, Géraldine, additional, Menegaux, Florence, additional, Truong, Thérèse, additional, Koudou, Yves Akoli, additional, John, Esther M., additional, Grindedal, Eli Marie, additional, Maehle, Lovise, additional, Khaw, Kay-Tee, additional, Ingles, Sue A., additional, Stern, Mariana C., additional, Vega, Ana, additional, Gómez-Caamaño, Antonio, additional, Fachal, Laura, additional, Rosenstein, Barry S., additional, Kerns, Sarah L., additional, Ostrer, Harry, additional, Teixeira, Manuel R., additional, Paulo, Paula, additional, Brandão, Andreia, additional, Watya, Stephen, additional, Lubwama, Alexander, additional, Bensen, Jeannette T., additional, Fontham, Elizabeth T. H., additional, Mohler, James, additional, Taylor, Jack A., additional, Kogevinas, Manolis, additional, Llorca, Javier, additional, Castaño-Vinyals, Gemma, additional, Cannon-Albright, Lisa, additional, Teerlink, Craig C., additional, Huff, Chad D., additional, Strom, Sara S., additional, Multigner, Luc, additional, Blanchet, Pascal, additional, Brureau, Laurent, additional, Kaneva, Radka, additional, Slavov, Chavdar, additional, Mitev, Vanio, additional, Leach, Robin J., additional, Weaver, Brandi, additional, Brenner, Hermann, additional, Cuk, Katarina, additional, Holleczek, Bernd, additional, Saum, Kai-Uwe, additional, Klein, Eric A., additional, Hsing, Ann W., additional, Kittles, Rick A., additional, Murphy, Adam B., additional, Logothetis, Christopher J., additional, Kim, Jeri, additional, Neuhausen, Susan L., additional, Steele, Linda, additional, Ding, Yuan Chun, additional, Isaacs, William B., additional, Nemesure, Barbara, additional, Hennis, Anselm J. M., additional, Carpten, John, additional, Pandha, Hardev, additional, Michael, Agnieszka, additional, De Ruyck, Kim, additional, De Meerleer, Gert, additional, Ost, Piet, additional, Xu, Jianfeng, additional, Razack, Azad, additional, Lim, Jasmine, additional, Teo, Soo-Hwang, additional, Newcomb, Lisa F., additional, Lin, Daniel W., additional, Fowke, Jay H., additional, Neslund-Dudas, Christine, additional, Rybicki, Benjamin A., additional, Gamulin, Marija, additional, Lessel, Davor, additional, Kulis, Tomislav, additional, Usmani, Nawaid, additional, Singhal, Sandeep, additional, Parliament, Matthew, additional, Claessens, Frank, additional, Joniau, Steven, additional, Van den Broeck, Thomas, additional, Gago-Dominguez, Manuela, additional, Castelao, Jose Esteban, additional, Martinez, Maria Elena, additional, Larkin, Samantha, additional, Townsend, Paul A., additional, Aukim-Hastie, Claire, additional, Bush, William S., additional, Aldrich, Melinda C., additional, Crawford, Dana C., additional, Srivastava, Shiv, additional, Cullen, Jennifer C., additional, Petrovics, Gyorgy, additional, Casey, Graham, additional, Roobol, Monique J., additional, Jenster, Guido, additional, van Schaik, Ron H. N., additional, Hu, Jennifer J., additional, Sanderson, Maureen, additional, Varma, Rohit, additional, McKean-Cowdin, Roberta, additional, Torres, Mina, additional, Mancuso, Nicholas, additional, Berndt, Sonja I., additional, Van Den Eeden, Stephen K., additional, Easton, Douglas F., additional, Chanock, Stephen J., additional, Cook, Michael B., additional, Wiklund, Fredrik, additional, Nakagawa, Hidewaki, additional, Witte, John S., additional, Eeles, Rosalind A., additional, Kote-Jarai, Zsofia, additional, and Haiman, Christopher A., additional
- Published
- 2021
- Full Text
- View/download PDF
4. Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
- Author
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Fesinmeyer, Megan D, primary, Meigs, James B, additional, North, Kari E, additional, Schumacher, Fredrick R, additional, Bůžková, Petra, additional, Franceschini, Nora, additional, Haessler, Jeffrey, additional, Goodloe, Robert, additional, Spencer, Kylee L, additional, Voruganti, Venkata Saroja, additional, Howard, Barbara V, additional, Jackson, Rebecca, additional, Kolonel, Laurence N, additional, Liu, Simin, additional, Manson, JoAnn E, additional, Monroe, Kristine R, additional, Mukamal, Kenneth, additional, Dilks, Holli H, additional, Pendergrass, Sarah A, additional, Nato, Andrew, additional, Wan, Peggy, additional, Wilkens, Lynne R, additional, Marchand, Loic Le, additional, Ambite, José Luis, additional, Buyske, Steven, additional, Florez, Jose C, additional, Crawford, Dana C, additional, Hindorff, Lucia A, additional, Haiman, Christopher A, additional, Peters, Ulrike, additional, and Pankow, James S, additional
- Published
- 2013
- Full Text
- View/download PDF
5. A genome-wide association study of breast cancer in women of African ancestry
- Author
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Chen, Fang, primary, Chen, Gary K., additional, Stram, Daniel O., additional, Millikan, Robert C., additional, Ambrosone, Christine B., additional, John, Esther M., additional, Bernstein, Leslie, additional, Zheng, Wei, additional, Palmer, Julie R., additional, Hu, Jennifer J., additional, Rebbeck, Tim R., additional, Ziegler, Regina G., additional, Nyante, Sarah, additional, Bandera, Elisa V., additional, Ingles, Sue A., additional, Press, Michael F., additional, Ruiz-Narvaez, Edward A., additional, Deming, Sandra L., additional, Rodriguez-Gil, Jorge L., additional, DeMichele, Angela, additional, Chanock, Stephen J., additional, Blot, William, additional, Signorello, Lisa, additional, Cai, Qiuyin, additional, Li, Guoliang, additional, Long, Jirong, additional, Huo, Dezheng, additional, Zheng, Yonglan, additional, Cox, Nancy J., additional, Olopade, Olufunmilayo I., additional, Ogundiran, Temidayo O., additional, Adebamowo, Clement, additional, Nathanson, Katherine L., additional, Domchek, Susan M., additional, Simon, Michael S., additional, Hennis, Anselm, additional, Nemesure, Barbara, additional, Wu, Suh-Yuh, additional, Leske, M. Cristina, additional, Ambs, Stefan, additional, Hutter, Carolyn M., additional, Young, Alicia, additional, Kooperberg, Charles, additional, Peters, Ulrike, additional, Rhie, Suhn K., additional, Wan, Peggy, additional, Sheng, Xin, additional, Pooler, Loreall C., additional, Van Den Berg, David J., additional, Le Marchand, Loic, additional, Kolonel, Laurence N., additional, Henderson, Brian E., additional, and Haiman, Christopher A., additional
- Published
- 2012
- Full Text
- View/download PDF
6. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21
- Author
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Haiman, Christopher A, primary, Chen, Gary K, additional, Blot, William J, additional, Strom, Sara S, additional, Berndt, Sonja I, additional, Kittles, Rick A, additional, Rybicki, Benjamin A, additional, Isaacs, William B, additional, Ingles, Sue A, additional, Stanford, Janet L, additional, Diver, W Ryan, additional, Witte, John S, additional, Hsing, Ann W, additional, Nemesure, Barbara, additional, Rebbeck, Timothy R, additional, Cooney, Kathleen A, additional, Xu, Jianfeng, additional, Kibel, Adam S, additional, Hu, Jennifer J, additional, John, Esther M, additional, Gueye, Serigne M, additional, Watya, Stephen, additional, Signorello, Lisa B, additional, Hayes, Richard B, additional, Wang, Zhaoming, additional, Yeboah, Edward, additional, Tettey, Yao, additional, Cai, Qiuyin, additional, Kolb, Suzanne, additional, Ostrander, Elaine A, additional, Zeigler-Johnson, Charnita, additional, Yamamura, Yuko, additional, Neslund-Dudas, Christine, additional, Haslag-Minoff, Jennifer, additional, Wu, William, additional, Thomas, Venetta, additional, Allen, Glenn O, additional, Murphy, Adam, additional, Chang, Bao-Li, additional, Zheng, S Lilly, additional, Leske, M Cristina, additional, Wu, Suh-Yuh, additional, Ray, Anna M, additional, Hennis, Anselm J M, additional, Thun, Michael J, additional, Carpten, John, additional, Casey, Graham, additional, Carter, Erin N, additional, Duarte, Edder R, additional, Xia, Lucy Y, additional, Sheng, Xin, additional, Wan, Peggy, additional, Pooler, Loreall C, additional, Cheng, Iona, additional, Monroe, Kristine R, additional, Schumacher, Fredrick, additional, Le Marchand, Loic, additional, Kolonel, Laurence N, additional, Chanock, Stephen J, additional, Berg, David Van Den, additional, Stram, Daniel O, additional, and Henderson, Brian E, additional
- Published
- 2011
- Full Text
- View/download PDF
7. Dense breast stromal tissue shows greatly increased concentration of breast epithelium but no increase in its proliferative activity
- Author
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Hawes, Debra, primary, Downey, Susan, additional, Pearce, Celeste Leigh, additional, Bartow, Sue, additional, Wan, Peggy, additional, Pike, Malcolm C, additional, and Wu, Anna H, additional
- Published
- 2006
- Full Text
- View/download PDF
8. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
- Author
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Conti, David V, Darst, Burcu F, Moss, Lilit C, Saunders, Edward J, Sheng, Xin, Chou, Alisha, Schumacher, Fredrick R, Olama, Ali Amin Al, Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N, Sahimi, Ali, Hoffmann, Thomas J, Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Muir, Kenneth, Lophatananon, Artitaya, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne R, Stevens, Victoria L, Gapstur, Susan M, Carter, Brian D, Schleutker, Johanna, Tammela, Teuvo LJ, Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G, Southey, Melissa C, MacInnis, Robert J, Cybulski, Cezary, Wokołorczyk, Dominika, Lubiński, Jan, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Nordestgaard, Børge G, Nielsen, Sune F, Weischer, Maren, Bojesen, Stig E, Røder, Martin Andreas, Iversen, Peter, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Horvath, Lisa, Clements, Judith A, Tilley, Wayne, Risbridger, Gail P, Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordström, Tobias, Pashayan, Nora, Dunning, Alison M, Ghoussaini, Maya, Travis, Ruth C, Key, Tim J, Riboli, Elio, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie J, Mucci, Lorelei A, Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J, Penney, Kathryn L, Turman, Constance, Tangen, Catherine M, Goodman, Phyllis J, Thompson, Ian M, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L, Ostrander, Elaine A, Geybels, Milan S, Koutros, Stella, Freeman, Laura E Beane, Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L, Hoover, Robert N, Machiela, Mitchell J, Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J, Zheng, Wei, Yeboah, Edward D, Mensah, James E, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, West, Catharine ML, Burnet, Neil, Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S, Drake, Bettina F, Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M, Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A, Stern, Mariana C, Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S, Kerns, Sarah L, Ostrer, Harry, Teixeira, Manuel R, Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T, Fontham, Elizabeth TH, Mohler, James, Taylor, Jack A, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C, Huff, Chad D, Strom, Sara S, Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J, Weaver, Brandi, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Saum, Kai-Uwe, Klein, Eric A, Hsing, Ann W, Kittles, Rick A, Murphy, Adam B, Logothetis, Christopher J, Kim, Jeri, Neuhausen, Susan L, Steele, Linda, Ding, Yuan Chun, Isaacs, William B, Nemesure, Barbara, Hennis, Anselm JM, Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F, Lin, Daniel W, Fowke, Jay H, Neslund-Dudas, Christine, Rybicki, Benjamin A, Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van Den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A, Aukim-Hastie, Claire, Bush, William S, Aldrich, Melinda C, Crawford, Dana C, Srivastava, Shiv, Cullen, Jennifer C, Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J, Jenster, Guido, Van Schaik, Ron HN, Hu, Jennifer J, Sanderson, Maureen, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Mancuso, Nicholas, Berndt, Sonja I, Van Den Eeden, Stephen K, Easton, Douglas F, Chanock, Stephen J, Cook, Michael B, Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S, Eeles, Rosalind A, Kote-Jarai, Zsofia, and Haiman, Christopher A
- Subjects
Male ,Genetic Loci ,Risk Factors ,Racial Groups ,Odds Ratio ,Humans ,Prostatic Neoplasms ,Genetic Predisposition to Disease ,Molecular Sequence Annotation ,Neoplasm Invasiveness ,Middle Aged ,3. Good health ,Genome-Wide Association Study - Abstract
Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.
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