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41 results on '"Vriendenkring VUB"'

1. Tauch-, Surf- und Schwimmfolgen

Author: Michel, O and Vriendenkring VUB
Subjects: Diving/adverse effects, swimmers ear, surfers ear, General Medicine, barotrauma, barosinusitis, Decompression Sickness
Published: 2022

2. Holocene climate changes explain the spatial pattern in genetic diversity in populations of Cyperus papyrus from Southeast Africa wetlands

Author: Elias Luís Maxombe, Lucas Donizetti Vieira, Tim Sierens, Ludwig Triest, Rosane Garcia Collevatti, Department of General Biology, Erasmushogeschool Brussel, Vriendenkring VUB, and General Botany and Nature Management
Subjects: Wetlands, Climate Change, Cyperus/genetics, Genetics, Genetic Variation, Cyperus, Ecosystem, Genetics (clinical)
Abstract: Wetlands are one of the most threatened ecosystems in the world because more than 70% of the area worldwide has been lost since 1900. Wetland plant species rely greatly on water for seeds and propagules, which may lead to a downstream unidirectional dispersal and accumulation of genetic diversity downstream. However, several species show no support for unidirectional genetic diversity, revealing the complexity of population dynamics and gene flow in wetlands. Here, we used microsatellite loci to address how the past demographic dynamics shaped the contemporary spatial pattern in genetic diversity and population structure of Cyperus papyrus in wetlands of Southeast Africa. Using spatially explicit analysis and coalescent modelling, we found no support for unidirectional dispersal. Instead, we found higher genetic diversity in populations upstream than downstream in the river basin. We also found high admixture among populations, most likely due to connections between adjacent river basins during sporadic floods, and ongoing gene flow due to bird-mediated seed dispersal. Our results suggest stepping-stone migration due to strong isolation-by-distance, but not necessarily unidirectional. Moreover, the past demographic dynamics in the Holocene shaped the current pattern of genetic diversity and structure, leading to higher genetic diversity in populations upstream the Zambezi river basin. Our results also point to the very low genetic diversity of C. papyrus populations in Southeast Africa and the need for management and conservation strategies to guarantee the long-term persistence of the species in the region.
Published: 2022

3. Upgrade of recommended nuclear cross section data base for production of therapeutic radionuclides

Author: F. Tárkányi, A. Hermanne, A. V. Ignatyuk, S. Takács, R. Capote, Vriendenkring VUB, and Applied Physics and Photonics
Subjects: Nuclear Energy and Engineering, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Radiology, Nuclear Medicine and imaging, DEUTERON-INDUCED REACTIONSPROTON-INDUCED REACTIONSPARTICLE INDUCED REACTIONSEXCITATION-FUNCTIONSNO-CARRIERNATURAL TUNGSTENMODEL CALCULATIONSCYCLOTRON PRODUCTIONXN REACTIONSOS-NAT, Pollution, Spectroscopy, Analytical Chemistry
Abstract: The IAEA Nuclear Data Section has coordinated several actions to setup and improve a database for recommended cross sections and nuclear decay data for various charged-particle reactions that can be used for medical radionuclide production. Some of the earlier evaluations did not provide uncertainties for the recommended cross sections. Updated evaluations with uncertainty quantification for 25 reactions relevant for production of 67Cu, 103Pd, 102mgRh, 114mIn, 125I, 169Yb, 177gLu, 186Re, 192Ir and 210,211At therapeutic radioisotopes are presented. Recommended cross-section data and their uncertainties for production of therapeutic radionuclides are available on the Web page of the IAEA Nuclear Data Section at https://nds.iaea.org/radionuclides and also at the IAEA medical portal https://nds.iaea.org/medportal.
Published: 2022

4. Assessment of formats and completeness of paper-based referral letters among urban hospitals in Rwanda: a retrospective baseline study

Author: Zamzam Kalume, Bart Jansen, Marc Nyssen, Jan Cornelis, Frank Verbeke, Jean Paul Niyoyita, Electronics and Informatics, Faculty of Engineering, Vriendenkring VUB, Biostatistics and medical informatics, Audio Visual Signal Processing, Faculty of Medicine and Pharmacy, and Public Health Sciences
Subjects: Hospitals, Urban, Referral completeness, Pregnancy, Health Policy, Infant, Newborn, Rwanda, Humans, Female, Patient referral, Referral letters, Referral and Consultation, Retrospective Studies, Hospitals, Private
Abstract: Background Patient referral is a process in which a healthcare provider decides to seek assistance due to the limitations of available skills, resources and services offered locally. Paper-based referrals predominantly used in low-income countries hardly follow any procedure. This causes a major gap in communication, coordination, and continuity of care between primary and specialized levels, leading to poor access, delay, duplication and unnecessary costs. The goal of this study is to assess the formats and completeness of existing paper-based referral letters in order to improve health information exchange, coordination, and continuity of care. Methods A retrospective exploratory research was conducted in eight public and three private healthcare facilities in the city of Kigali from May to October 2021. A purposive sampling method was used to select hospitals and referral letters from patients’ files. A data capture sheet was designed according to the contents of the referral letters and the resulting responses were analyzed descriptively. Results In public hospitals, five types of updated referral letters were available, in total agreement with World Health Organization (WHO) standards of which two (neonatal transfer form and patient monitoring transfer form) were not used. There was also one old format that was used by most hospitals and another format designed and used by a district hospital (DH) separately. Three formats were designed and used by private hospitals (PH) individually. A total of 2,304 referral letters were perused and the results show that “external transfer” forms were completed at 58.8%; “antenatal, delivery, and postnatal external transfer” forms at 47.5%; “internal transfer” forms at 46.6%; “Referral/counter referral” forms at 46.0%; district hospital referrals (DH2) at 73.4%. Referrals by private hospitals (PH1, PH2 and PH3) were completed at 97.7%, 70.7%, and 0.0% respectively. The major completeness deficit was observed in counter referral information for all hospitals. Conclusion We observed inconsistencies in the format of the available referral letters used by public hospitals, moreover some of them were incompatible with WHO standards. Additionally, there were deficits in the completeness of all types of paper-based referral letters in use. There is a need for standardization and to disseminate the national patient referral guideline in public hospitals with emphasis on referral feedback, referral registry, triage, archiving and a need for regular training in all organizations.
Published: 2022

5. Durvalumab-induced thyroiditis in a patient with non-small cell lung carcinoma: a case report and review of pathogenic mechanisms

Author: Jeroen M. K. de Filette, Stéphanie André, Lynn De Mey, Sandrine Aspeslagh, Rafik Karmali, Bart J Van der Auwera, Bert Bravenboer, Brussels Heritage Lab, Diabetes Clinic, Supporting clinical sciences, Nuclear Medicine, Faculty of Medicine and Pharmacy, Laboratory for Medical and Molecular Oncology, Clinical sciences, Medical Oncology, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, and Vriendenkring VUB
Subjects: Thyroiditis, Lung Neoplasms, Carcinoma, Non-Small-Cell Lung/drug therapy, Endocrinology, Diabetes and Metabolism, Antibodies, Monoclonal, General Medicine, Middle Aged, Thyroiditis/chemically induced, Antibodies, Monoclonal/adverse effects, Immune Checkpoint Inhibitors/adverse effects, Carcinoma, Non-Small-Cell Lung, oncology, Humans, Female, Lung Neoplasms/drug therapy, Immune Checkpoint Inhibitors
Abstract: Background Immune checkpoint inhibitors (ICI) targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 and its ligand (PD-1/PD-L1) have become the current standard-of-care for advanced cancers. This novel therapeutic approach comes with its costs in the form of immune-related adverse events (irAE), including endocrinopathy. Case presentation A 63-year-old woman was diagnosed with a non-small cell lung carcinoma of the right superior lobe, cT3N2M0. She developed thyrotoxicosis followed by hypothyroidism induced by consolidation immunotherapy with durvalumab (anti-PD-L1). Analysis of the human leukocyte antigen (HLA) region showed HLA-DR4 (susceptible) and DR13 (protective). The possible mechanisms are subsequently discussed in detail. Conclusions The case of a patient with thyroiditis associated with the PD-L1 inhibitor durvalumab is described, highlighting the need for proactive monitoring of thyroid hormone levels. Identifying biomarkers associated with an increased risk of ICI-induced side effects (such as HLA) is of interest for better patient selection, optimal management and improved understanding of the mechanisms involved.
Published: 2022

6. A randomised, single-blind, placebo-controlled, dose-finding safety and tolerability study of the anti-CD3 monoclonal antibody otelixizumab in new-onset type 1 diabetes

Author: Bart O. Roep, Nicolas Wisniacki, Rene J. Mclaughlin, Pieter Gillard, Robert Hilbrands, Frans Gorus, João Joaquim Oliveira, Chantal Mathieu, Antonella Napolitano, André van Maurik, Dave Inman, Bart Keymeulen, Rachel M. Gittelman, Ursule Van de Velde, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Diabetes Clinic, Vriendenkring VUB, and UZB Other
Subjects: Adult, Male, Epstein-Barr Virus Infections, medicine.medical_specialty, Adolescent, type 1 diabetes, Endocrinology, Diabetes and Metabolism, Antibodies, Monoclonal, Humanized, Placebo, Article, Young Adult, Anti-CD3 monoclonal antibody, Insulin-Secreting Cells, Internal medicine, Insulin Secretion, Internal Medicine, medicine, Humans, Single-Blind Method, Autoreactive T cell, Adverse effect, Islet autoimmunity, Type 1 diabetes, C-Peptide, Dose-Response Relationship, Drug, business.industry, Epstein–Barr virus reactivation, Otelixizumab, medicine.disease, Cytokine release syndrome, Diabetes Mellitus, Type 1, Tolerability, Tolerability Study, Disease Progression, Latent Infection, Female, business, medicine.drug
Abstract: Aims/hypothesis Numerous clinical studies have investigated the anti-CD3ɛ monoclonal antibody otelixizumab in individuals with type 1 diabetes, but limited progress has been made in identifying the optimal clinical dose with acceptable tolerability and safety. The aim of this study was to evaluate the association between dose–response, safety and tolerability, beta cell function preservation and the immunological effects of otelixizumab in new-onset type 1 diabetes. Methods In this randomised, single-blind, placebo-controlled, 24 month study, conducted in five centres in Belgium via the Belgian Diabetes Registry, participants (16–27 years old, n = 40). Randomisation to treatment was by a central computer system; only participants and bedside study personnel were blinded to study treatment. The co-primary endpoints were the incidence of adverse events, the rate of Epstein–Barr virus (EBV) reactivation, and laboratory measures and vital signs. A mixed-meal tolerance test was used to assess beta cell function; exploratory biomarkers were used to measure T cell responses. Results Thirty participants were randomised/28 were analysed (placebo, n = 6/5; otelixizumab 9 mg, n = 9/8; otelixizumab 18 mg, n = 8/8; otelixizumab 27 mg, n = 7/7; otelixizumab 36 mg, n = 0). Dosing was stopped at otelixizumab 27 mg as the predefined EBV reactivation stopping criteria were met. Adverse event frequency and severity were dose dependent; all participants on otelixizumab experienced at least one adverse event related to cytokine release syndrome during the dosing period. EBV reactivation (otelixizumab 9 mg, n = 2/9; 18 mg, n = 4/8: 27 mg, n = 5/7) and clinical manifestations (otelixizumab 9 mg, n = 0/9; 18 mg, n = 1/8; 27 mg, n = 3/7) were rapid, dose dependent and transient, and were associated with increased productive T cell clonality that diminished over time. Change from baseline mixed-meal tolerance test C-peptide weighted mean AUC0–120 min following otelixizumab 9 mg was above baseline for up to 18 months (difference from placebo 0.39 [95% CI 0.06, 0.72]; p = 0.023); no beta cell function preservation was observed at otelixizumab 18 and 27 mg. Conclusions/interpretation A metabolic response was observed with otelixizumab 9 mg, while doses higher than 18 mg increased the risk of unwanted clinical EBV reactivation. Although otelixizumab can temporarily compromise immunocompetence, allowing EBV to reactivate, the effect is dose dependent and transient, as evidenced by a rapid emergence of EBV-specific T cells preceding long-term control over EBV reactivation. Trial registration ClinicalTrials.gov NCT02000817. Funding The study was funded by GlaxoSmithKline.
Published: 2020

7. Hilbert sEMG data scanning for hand gesture recognition based on deep learning

Author: Bart Jansen, Athanassios N. Skodras, Bruno Cornelis, Jan Cornelis, Panagiotis Tsinganos, Electronics and Informatics, Faculty of Engineering, Vriendenkring VUB, Translational Imaging Research Alliance, and Audio Visual Signal Processing
Subjects: Contextual image classification, Computer science, business.industry, Deep learning, 0206 medical engineering, Pattern recognition, Image processing, Hilbert curve, 02 engineering and technology, 020601 biomedical engineering, Convolutional neural network, Field (computer science), Artificial Intelligence, Gesture recognition, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Artificial intelligence, business, Software
Abstract: Deep learning has transformed the field of data analysis by dramatically improving the state of the art in various classification and prediction tasks, especially in the area of computer vision. In biomedical engineering, a lot of new work is directed toward surface electromyography (sEMG)-based gesture recognition, often addressed as an image classification problem using convolutional neural networks (CNNs). In this paper, we utilize the Hilbert space-filling curve for the generation of image representations of sEMG signals, which allows the application of typical image processing pipelines such as CNNs on sequence data. The proposed method is evaluated on different state-of-the-art network architectures and yields a significant classification improvement over the approach without the Hilbert curve. Additionally, we develop a new network architecture (MSHilbNet) that takes advantage of multiple scales of an initial Hilbert curve representation and achieves equal performance with fewer convolutional layers.
Published: 2020

8. Human hepatic in vitro models reveal distinct anti-NASH potencies of PPAR agonists

Author: Vera Rogiers, Anja Heymans, Joost Boeckmans, Veerle De Boe, Matthias Rombaut, Joery De Kock, Tamara Vanhaecke, Alessandra Natale, Brent Cami, Robim Marcelino Rodrigues, Karolien Buyl, Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Experimental in vitro toxicology and dermato-cosmetology, Urology, Vriendenkring VUB, and Connexin Signalling Research Group
Subjects: 0301 basic medicine, Saroglitazar, Health, Toxicology and Mutagenesis, Peroxisome Proliferator-Activated Receptors, Peroxisome proliferator-activated receptor, Pharmacology, Toxicology, Models, Biological, PPAR agonist, Pharmacology, Toxicology and Pharmaceutics(all), 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, medicine, Humans, Non-alcoholic steatohepatitis (NASH), Child, Skin, chemistry.chemical_classification, Pioglitazone, Chemistry, Lipogenesis, in vitro, Hep G2 Cells, Cell Biology, medicine.disease, Elafibranor, digestive system diseases, 030104 developmental biology, Gene Expression Regulation, Liver, Peroxisome proliferator-activated receptor (PPAR), Child, Preschool, 030220 oncology & carcinogenesis, Chemokine secretion, Hepatic stellate cell, Chemokines, Inflammation Mediators, Steatohepatitis, Rosiglitazone, Transcription Factors, medicine.drug
Abstract: Non-alcoholic steatohepatitis (NASH) is a highly prevalent, chronic liver disease characterized by hepatic lipid accumulation, inflammation, and concomitant fibrosis. Up to date, no anti-NASH drugs have been approved. In this study, we reproduced key NASH characteristics in vitro by exposing primary human hepatocytes (PHH), human skin stem cell-derived hepatic cells (hSKP-HPC), HepaRG and HepG2 cell lines, as well as LX-2 cells to multiple factors that play a role in the onset of NASH. The obtained in vitro disease models showed intracellular lipid accumulation, secretion of inflammatory chemokines, induced ATP content, apoptosis, and increased pro-fibrotic gene expression. These cell systems were then used to evaluate the anti-NASH properties of eight peroxisome proliferator-activated receptor (PPAR) agonists (bezafibrate, elafibranor, fenofibrate, lanifibranor, pemafibrate, pioglitazone, rosiglitazone, and saroglitazar). PPAR agonists differently attenuated lipid accumulation, inflammatory chemokine secretion, and pro-fibrotic gene expression.Based on the obtained readouts, a scoring system was developed to grade the anti-NASH potencies. The in vitro scoring system, based on a battery of the most performant models, namely PHH, hSKP-HPC, and LX-2 cultures, showed that elafibranor, followed by saroglitazar and pioglitazone, induced the strongest anti-NASH effects. These data corroborate available clinical data and show the relevance of these in vitro models for the preclinical investigation of anti-NASH compounds.
Published: 2020

9. Investigation of the deuteron induced nuclear reaction cross sections on lutetium up to 50 MeV: review of production routes for 177Lu, 175Hf and 172Hf via charged particle activation

Author: A.V. Ignatyuk, Alex Hermanne, F. Tárkányi, Fenyvesy Ditroi, R. Adam-Rebeles, Sandor Takacs, Vriendenkring VUB, Brussels Photonics Team, and Applied Physics and Photonics
Subjects: Nuclear reaction, Materials science, Health, Toxicology and Mutagenesis, EXCITATION-FUNCTIONS, NATURAL YTTERBIUM, NO-CARRIER, NAT, chemistry.chemical_element, 010403 inorganic & nuclear chemistry, Mass spectrometry, 01 natural sciences, 030218 nuclear medicine & medical imaging, Analytical Chemistry, Nuclear physics, 03 medical and health sciences, Cross section (physics), 0302 clinical medicine, Radiology, Nuclear Medicine and imaging, Spectroscopy, FOIL method, Public Health, Environmental and Occupational Health, Pollution, Lutetium, Charged particle, 0104 chemical sciences, Nuclear Energy and Engineering, chemistry, Deuterium, Excitation
Abstract: In a systematic study of light charged particle induced nuclear reactions we investigated the excitation functions of deuteron induced nuclear reactions on natural lutetium targets. Experimental excitation functions up to 50 MeV on high purity natLu were determined using the standard stacked foil activation technique. High resolution off-line gamma-ray spectrometry was applied to assess the activity of each foil. From the measured activity direct and/or cumulative elemental cross-section data for production of 171,172,173,175Hf, 171,172,173,174g,176m,177m,177gLu and 169Yb radioisotopes were determined. The experimental data were compared to results of the TALYS theoretical code taken from the TENDL databases and results of our calculations using the ALICE-IPPE-D and the EMPIRE-D codes. No earlier experimental data were found in the literature. Thick target yields for the investigated radionuclides were calculated from the measured excitation functions.
Published: 2020

10. Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults

Author: Bauer, J. M., Mikusova, L., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., Mets, T., Wijers, S. L. J., Garthoff, J. A., Luiking, Y., Sieber, C., Cederholm, T., Mcmurdo, M. E. T., Seal, C., Ceda, G. P., De Vito, G., Donders, G., Drey, M., Greig, C., Holmback, U., Narici, M., Mcphee, J., Poggiogalle, E., Power, D., Scafoglieri, A., Schultz, R., Internal medicine, Research in Geriatrics and Gerontology, Gerontology, Rehabilitation Research, Physical Medicine and Rehabilitation, Frailty in Ageing, Vriendenkring VUB, Geriatrics, Physiotherapy, Human Physiology and Anatomy, and Body Composition and Morphology
Subjects: Male, safety, Sarcopenia, Aging, medicine.medical_specialty, chemistry.chemical_element, Parathyroid hormone, Renal function, 030209 endocrinology & metabolism, Calcium, Gastroenterology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, Leucine, law, Internal medicine, medicine, Vitamin D and neurology, Humans, ddc:610, 030212 general & internal medicine, Vitamin D, Aged, Nutrition, Medicine(all), Nutrition and Dietetics, business.industry, Safety, Tolerability, Whey protein, medicine.disease, Näringslära, Whey Proteins, chemistry, Dietary Supplements, Original Article, Female, Geriatrics and Gerontology, business, Kidney disease
Abstract: Aims Safety and tolerability of prolonged supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink (WP-MND) was evaluated in sarcopenic older adults. Methods A 13-week double-blinded, randomized, isocaloric placebo-controlled trial (PROVIDE study; n = 380) was extended with a voluntary 13-week open-label extension (OLE). OLE participants were randomized to receive daily 1 or 2 servings of WP-MND (21 g protein, 3 g leucine, 10 µg vitD and 500 mg calcium per serving). Gastro-intestinal tolerability, kidney function and serum levels of calcidiol, parathyroid hormone (PTH) and calcium were evaluated at week 0, 13 and 26. Results and discussion In response to the high daily protein intake (median1.5; IQR: 1.3, 1.7 g/kg BW/day), the estimated glomerular filtration rate (eGFR) increased in the test group during the RCT (p = 0.013). The same trend was observed for those participants with moderate chronic kidney disease. During OLE no eGFR change was observed in any of the groups. Serum calcidiol and calcium reached a plateau after 13-week WP-MND supplementation. As expected, PTH significantly changed in the opposite direction, decreasing during RCT in the test group (T vs C: p n = 18; C: n = 2) and 6 developed albumin-corrected calcium levels > 2.55 mmol/L (T: n = 3; C: n = 3), without associated adverse events. Conclusion A 6 months intervention with up to 2 servings of WP-MND did neither result in kidney function deterioration nor symptoms of vitamin D or calcium toxicity. The product was overall well tolerated.
Published: 2020

11. Activation cross sections of gamma-emitters produced in deuteron induced reactions on $${}^{{209}}$$Bi up to 50 MeV

Author: Zoltán Szűcs, A. V. Ignatyuk, K. Brezovcsik, F. Tárkányi, F. Ditrói, Alex Hermanne, Sandor Takacs, Vriendenkring VUB, and Applied Physics and Photonics
Subjects: Physics, Nuclear and High Energy Physics, 010308 nuclear & particles physics, Activation technique, Hadron, chemistry.chemical_element, 010403 inorganic & nuclear chemistry, 01 natural sciences, 0104 chemical sciences, Bismuth, Deuterium, chemistry, 0103 physical sciences, Nuclear fusion, Atomic physics, Excitation, FOIL method
Abstract: Deuteron induced reactions on natural bismuth targets were investigated with the stacked foil activation technique up to 50 MeV. Excitation functions for the reactions $$^{\mathrm {209}}$$ 209 Bi(d,xn)$$^{\mathrm {207,206,205}}$$ 207 , 206 , 205 Po, Bi(d,x)$$^{\mathrm {207,205}}$$ 207 , 205 Bi and $$^{\mathrm {209}}$$ 209 Bi(d,x)$$^{\mathrm {203}}$$ 203 Pb obtained from gamma-spectra of decay products were compared with the results of our ALICE-D and EMPIRE-D model calculations, with the result of TALYS code taken from TENDL-2019 on-line library and the results of the only measurement performed earlier. Thick target yields were deduced from the fitted experimental cross sections.
Published: 2021

12. Technological advancements for the development of stem cell-based models for hepatotoxicity testing

Author: Robim Marcelino Rodrigues, Jurgen Van Erps, Matij Buzgo, Joost Boeckmans, Peter Dubruel, Koen Vanmol, Sandra Van Vlierberghe, Aysu Arslan, Alessandra Natale, Hugo Thienpont, Joery De Kock, Tamara Vanhaecke, Vera Rogiers, Experimental in vitro toxicology and dermato-cosmetology, Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Applied Physics and Photonics, Faculty of Engineering, Brussels Photonics Team, Connexin Signalling Research Group, and Vriendenkring VUB
Subjects: 0301 basic medicine, Cell type, Health, Toxicology and Mutagenesis, Cell, Cell Culture Techniques, 010501 environmental sciences, Biology, Animal Testing Alternatives, Toxicology, 01 natural sciences, Xenobiotics, 03 medical and health sciences, Directed differentiation, In vivo, medicine, Humans, 0105 earth and related environmental sciences, Stem Cells, Liver cell, Cell Differentiation, General Medicine, In vitro, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Liver, Cell culture, Hepatocytes, Chemical and Drug Induced Liver Injury, Stem cell
Abstract: Stem cells are characterized by their self-renewal capacity and their ability to differentiate into multiple cell types of the human body. Using directed differentiation strategies, stem cells can now be converted into hepatocyte-like cells (HLCs) and therefore, represent a unique cell source for toxicological applications in vitro. However, the acquired hepatic functionality of stem cell-derived HLCs is still significantly inferior to primary human hepatocytes. One of the main reasons for this is that most in vitro models use traditional two-dimensional (2D) setups where the flat substrata cannot properly mimic the physiology of the human liver. Therefore, 2D-setups are progressively being replaced by more advanced culture systems, which attempt to replicate the natural liver microenvironment, in which stem cells can better differentiate towards HLCs. This review highlights the most recent cell culture systems, including scaffold-free and scaffold-based three-dimensional (3D) technologies and microfluidics that can be employed for culture and hepatic differentiation of stem cells intended for hepatotoxicity testing. These methodologies have shown to improve in vitro liver cell functionality according to the in vivo liver physiology and allow to establish stem cell-based hepatic in vitro platforms for the accurate evaluation of xenobiotics.
Published: 2019

13. Extension of experimental activation cross-sections database of deuteron induced nuclear reactions on manganese up to 50 MeV

Author: Ferenc Tarkanyi, Alex Hermanne, A.V. Ignatyuk, Fenyvesy Ditroi, Sandor Takacs, Vriendenkring VUB, Brussels Photonics Team, and Applied Physics and Photonics
Subjects: Nuclear reaction, Theoretical model codes, Health, Toxicology and Mutagenesis, chemistry.chemical_element, Manganese, 010403 inorganic & nuclear chemistry, Mass spectrometry, 01 natural sciences, Analytical Chemistry, Nuclear physics, Cross section (physics), Radiology, Nuclear Medicine and imaging, Spectroscopy, Physical yield, Physics, Cross section, Public Health, Environmental and Occupational Health, Experimental data, Mn, V and Cr radioisotopes, Pollution, 0104 chemical sciences, Off-line gamma spectrometry, Nuclear Energy and Engineering, chemistry, Deuterium, Radiology Nuclear Medicine and imaging, Deuteron irradiation, Monoisotopic mass, Activation method
Abstract: In the frame of a systematic study of activation cross sections of deuteron induced reactions, experimental cross section data were measured on Mn (monoisotopic Mn-55) up to 50MeV for the formation of Mn-56,Mn-54,Mn-52, V-48 and Cr-51 by using stacked-foil activation method and high resolution gamma spectrometry. The experimental data are compared with the earlier published data and with the results predicted by the ALICE-IPPE-D and EMPIRE-II-D theoretical codes, and with the data taken from the on-line TENDL-2017 library.
Published: 2019

14. Visualising multi-criteria weight elicitation by multiple stakeholders in complex decision systems

Author: Jean Pierre Brans, Pierre Louis Kunsch, Informatics and Applied Informatics, Business technology and Operations, and Vriendenkring VUB
Subjects: 0209 industrial biotechnology, Operations research, Process (engineering), Computer science, Strategy and Management, 0211 other engineering and technologies, Computational intelligence, 02 engineering and technology, Management Science and Operations Research, Likert scale, Visualisation tools, 020901 industrial engineering & automation, Modelling and Simulation, Management of Technology and Innovation, Multiple stakeholders, Numerical Analysis, 021103 operations research, Complex Systems, Weight elicitation, Multiple-criteria decision analysis, Elicitation technique, Visualization, System dynamics, Multiple criteria, Computational Theory and Mathematics, Modeling and Simulation, Statistics, Probability and Uncertainty, Decision analysis
Abstract: An efficient and transparent weight elicitation technique is proposed for inclusion into the adaptive, systemic, control and multi-criteria-based methodology, in short ASCM, the purpose of which is piloting in real time complex systems by combining system dynamics (SD) and multi-criteria decision analysis (MCDA). Piloting policies are established and revised on a regular basis and/or constant real-time observation by means of SD simulations; at each revision step groups of stakeholders choose by means of MCDA tools the best policy to be implemented for the ensuing time periods when adaptations are necessary to account for the actual system evolution. An essential but difficult issue at each policy revision step is the weight elicitation process of multiple criteria by the multiple stakeholder groups (SH). The proposed procedure with a strong mathematical background does not require excessive cognitive effort for SH with different priorities and decisional powers. It consists in a two-step approach defining firstly importance classes on ordinal Likert scales, and secondly profiles on those scales for the criteria. It appears to be simple though rigorous; it easily allows fast sensitivity analyses when confronting different opinions. A didactic example and a fishery-management case study illustrate these properties by means of visualisation tools facilitating consensus-seeking among SH.
Published: 2019

15. Investigation of cross sections of deuteron induced nuclear reactions on selenium up to 50 MeV

Author: Alex Hermanne, A. V. Ignatyuk, F. Ditrói, F. Tárkányi, Sandor Takacs, Károly Brezovcsik, Zoltán Szűcs, Vriendenkring VUB, Brussels Photonics Team, and Applied Physics and Photonics
Subjects: Physics, Nuclear reaction, Nuclear and High Energy Physics, 010308 nuclear & particles physics, Hadron, 0211 other engineering and technologies, 02 engineering and technology, 01 natural sciences, Deuterium, 0103 physical sciences, Production (computer science), Atomic physics, Activation method, Energy (signal processing), 021102 mining & metallurgy
Abstract: In the frame of a systematic study of deuteron induced nuclear reactions on all elements, activation cross sections on $$^{\mathrm {nat}}$$ nat Se were investigated. Excitation functions were measured up to 50 MeV particle energy for production of $$^{\mathrm {82}}$$ 82 Br(m$$+)$$ + ) ,$$^{\mathrm {80m}}$$ 80 m Br, $$^{\mathrm {77}}$$ 77 Br(m$$+)$$ + ) ,$$^{\mathrm {76}}$$ 76 Br(m$$+)$$ + ) , $$^{\mathrm {75}}$$ 75 Br, $$^{\mathrm {75}}$$ 75 Se(cum), $$^{\mathrm {73}}$$ 73 Se(cum), $$^{\mathrm {76}}$$ 76 As,$$^{\mathrm {74}}$$ 74 As, $$^{\mathrm {73}}$$ 73 As(cum), $$^{\mathrm {72}}$$ 72 As and $$^{\mathrm {71}}$$ 71 As(cum) by using the activation method through stacked foil irradiation followed by off-line gamma-ray spectrometry. The experimental results were compared to the earlier experimental data and to excitation functions calculated with the ALICE-D and EMPIRE-D theoretical model codes and data given in the TENDL-2019 on-line library based on TALYS calculations.
Published: 2021

16. Search for charged Higgs bosons decaying into a top and a bottom quark in the all-jet final state of pp collisions at $$ \sqrt{s} $$ = 13 TeV

Author: E. W. Vaandering, Alexander Titterton, V. Re, Jeremie Alexandre Merlin, Piotr Zalewski, C. Kleinwort, Xinmei Niu, Vitaly Smirnov, Prasant Kumar Rout, Jean-Louis Faure, Riccardo Paramatti, Andrea Giammanco, Priyanka Kumari, Dragos Velicanu, Qamar Hassan, Nuno Leonardo, Santeri Laurila, Alexander Schmidt, Nadir Daci, Vipin Bhatnagar, T. Liu, C-E Wulz, W. A. T. Wan Abdullah, Jamal Rorie, Jason Gilmore, Roberto Dell'Orso, J. W. Gary, Ashutosh Bhardwaj, Marco Paganoni, Don Lincoln, Sergey Troshin, Li Yuan, W. De Boer, K. F. Chen, Jory Sonneveld, Hafeez R Hoorani, David D'Enterria, G. Bagliesi, C. Madrid, Andris Skuja, Alessandro Cardini, Kelly Beernaert, Ivica Puljak, Helio Nogima, W. H. Smith, Elif Asli Yetkin, Alberto Orso Maria Iorio, Daniel John Karmgard, Manfred Jeitler, Fabrizio Palla, Peter Raics, Peicho Petkov, L. Malgeri, Kamuran Dilsiz, Seema Bahinipati, Paolo Rumerio, Leonardo Cristella, Lorenzo Uplegger, Owen Baron, Vivekanand Jha, Achille Petrilli, Chun-Hua Jiang, Felice Pantaleo, Chanwook Hwang, Mário Costa, Hans Reithler, Robert Hirosky, Niladribihari Sahoo, Apichart Hortiangtham, Dezso Horvath, Christina Reissel, Ryan Mueller, Steve Schnetzer, Saranya Ghosh, Klaas Padeken, Patrick Jarry, Ben Bylsma, Roberto Tenchini, Meng Xiao, Renato Campanini, Guido Tonelli, Zeljko Antunovic, Alexander Fröhlich, Sushil Chauhan, Christian Autermann, Jacobo Konigsberg, Rosamaria Venditti, W. J. Metzger, Kajari Mazumdar, Nickolas Mccoll, Demetra Tsiakkouri, Shawn Zaleski, Torben Dreyer, Alessia Tricomi, Nikolay Tyurin, Roumyana Hadjiiska, Kenneth Bloom, Thomas Perry, Igor Smirnov, Piergiulio Lenzi, Carlos Lourenco, A. G. Stahl Leiton, Andrej Saibel, Benjamin Krikler, M. De Mattia, G. Quast, Rishi Patel, Y. D. Oh, Marcus Hohlmann, Anup Kumar Sikdar, Y. Musienko, M. C. Fouz, Samuel Boren, Sharad Malik, Najaf Amin, A. Braghieri, Vytautas Dudenas, Kerstin Hoepfner, Samila Muthumuni, Hannsjoerg Artur Weber, Tai Sakuma, Gordon H. Hanson, Carlos Florez, Ilaria Vai, Salvatore My, T. A. Gómez Espinosa, Nicolas Postiau, Marco Musich, James Dolen, Maciej Misiura, Anterpreet Kaur, Fabrice Couderc, Gilvan Alves, M. Pelliccioni, Sridhara Dasu, Emilio Meschi, W. T. Lin, Dylan Hsu, Luca Perrozzi, Manfred Krammer, Kevin Sung, Yutaro Iiyama, Mehmet Kaya, Intae Yu, Freya Blekman, Raman Khurana, Tanushree Bose, Ilse Krätschmer, David Michael Morse, G. Hamel de Monchenault, Aditee Rane, Anna Teresa Meneguzzo, Fatma Boran, Manfred Paulini, F. Mohamad Idris, Malte Backhaus, Konstanty Sumorok, Alexandros Attikis, L. V. Kardapoltsev, Elena Voevodina, Amitabh Lath, Simon Kudella, Angela Mehta, A. Kasem, Nicholas Wardle, Raffaele Gerosa, Alexander Ledovskoy, Vincent J Smith, F. Vazzoler, Jessica Prisciandaro, Pierluigi Bortignon, Ugo Gasparini, Veikko Karimäki, Bradley Cox, K. Wong, Yen-Jie Lee, Doga Gulhan, Louis Lyons, Ettore Focardi, Matthias Schröder, Ulascan Sarica, Ioannis Papakrivopoulos, Laurent Thomas, Mark Derdzinski, Maria Toms, John Michael Marraffino, E. De La Cruz-Burelo, Kenneth Call, A. Rossi, Jaana Kristiina Heikkilä, Hugues Lattaud, Tao Huang, Anna Elliott-Peisert, Vuko Brigljevic, Bruno Wittmer, Lucia Silvestris, Andreas Psallidas, C. Vander Velde, David Taylor, B. Jayatilaka, Aran Garcia-Bellido, Srimoyee Sen, R. Bhattacharya, E. Carrera Jarrin, Douglas Wright, Isa Dumanoglu, Davide Zuolo, Giles Strong, Debarati Roy, Andrey Pozdnyakov, P. Van Hove, Alice Cocoros, Panagiotis Katsoulis, Stephen Mrenna, Denys Lontkovskyi, Konstantinos Manolopoulos, Marc Weinberg, John Rander, A. Di Crescenzo, Marco Zanetti, U. Bhawandeep, Tae Jeong Kim, Emmanouil Vourliotis, John Hakala, Michael Murray, Jakob Salfeld-Nebgen, Sebastian Wiedenbeck, Kunal Kothekar, Siddhesh Sawant, Nazar Bartosik, Marvin Johnson, N. Woods, Kyungwook Nam, Cesar Augusto Bernardes, Vladimir Ivanchenko, Sergey Guts, C. A. Carrillo Montoya, Zoltan Gecse, Luigi Fiore, Victor Murzin, Q. Li, Miaoyuan Liu, Katja Klein, Jens Multhaup, R. F. Harr, Furkan Dolek, Sara Fiorendi, Vasken Hagopian, G. M. Dallavalle, Bhargav Madhusudan Joshi, Georgios Krintiras, Matteo Presilla, Zeynep Demiragli, Marina Kolosova, Mauro Donegà, Igor Bayshev, H. Keller, V. Papadimitriou, R. D. Field, Bobak Hashemi, C. Martin Perez, H. El Mamouni, Mikhail Kirsanov, R. Cousins, B. Fabbro, C. Martinez Rivero, Giorgio Apollinari, Ulf Behrens, M. A. Shah, Charles Mueller, Benjamin Mesic, F. Pandolfi, Teruki Kamon, Fengwangdong Zhang, A. Scribano, Yi-ting Duh, Ashish Sharma, Franco Ligabue, S. Roy Chowdhury, Colin Jessop, M. Calderon De La Barca Sanchez, Cameron Bravo, Rachel Yohay, J. K. Lim, F. Simonetto, Sergio P Ratti, Lalit Mohan Pant, Kenneth Long, Andrea Carlo Marini, Alibordi Muhammad, James Buchanan, Maxim Pieters, A. Di Francesco, Ulrich Heintz, M. Kovac, Bjorn Burkle, Tom Cornelis, Shivali Malhotra, Tanmay Mudholkar, Ennio Monteil, Aldo Penzo, Valerie Scheurer, Marius Preuten, Markus Radziej, Roberto Mulargia, Matthias Kasemann, Cole Lindsey, Dylan Gilbert, Jim Hanlon, D. Soldi, Felicitas Pauss, Artur Kalinowski, Nicolas Tonon, Artur Gottmann, Aimilios Ioannou, Matteo Cremonesi, Nils Faltermann, Angira Rastogi, Duong Nguyen, Junquan Tao, Thoth Gunter, Kirti Ranjan, Milos Dordevic, Carsten Hensel, M. M. Defranchis, Yalcin Guler, Roger Wolf, Lev Dudko, Jeremy Andrea, Alexander Tapper, Vyacheslav Krutelyov, Nitish Dhingra, J. Suarez Gonzalez, You-ying Li, Kirika Uchida, P. Van Mechelen, A. Apyan, Andrew Beretvas, Otto Hindrichs, S. Mitra, Aashaq Shah, Frank Chlebana, Kuntal Mondal, Giovanni Organtini, Samuel Bein, Daniel Spitzbart, Boris Grynyov, Shengquan Tuo, Alessia Saggio, Alessandro Caratelli, Natale Demaria, N. Vanegas Arbelaez, Erhan Gülmez, Kaori Maeshima, Aurelijus Rinkevicius, L. Viliani, Martin Erdmann, Troy Mulholland, Alexis Pompili, J. G. Li, T. Tabarelli de Fatis, Vladyslav Danilov, Roberto Rossin, Nabin Poudyal, Sharon Hagopian, Ralf Ulrich, Siew Yan Hoh, Marta Verweij, Hong Ni, Paola Salvini, Florian Beaudette, Daniel Arcaro, Deborah Pinna, Caterina Vernieri, Marco Alexander Harrendorf, Fábio Lúcio Alves, Austin Baty, Vladimir Cherepanov, Andrew Wisecarver, Paolo Spagnolo, P. Gras, S. Choi, W. Ji, Claudio Quaranta, Seungkyu Ha, Abhigyan Dasgupta, Zviad Tsamalaidze, Nikolai Skatchkov, F. L. Fabbri, Daniele Fasanella, Matti J Kortelainen, N. Turini, Juliette Alimena, Paul Asmuss, A. De Cosa, Hannes Sakulin, Andrew Hart, Demetrios Loukas, Erik Butz, Jan Kieseler, Giulia Negro, Cheng-Chieh Peng, O. Kukral, Abhisek Datta, Hasan Ogul, Stephane Perries, S. Sánchez Navas, W. T. Ford, P. J. Fernández Manteca, Jose Chinellato, Richard Cavanaugh, Luca Guzzi, Pierluigi Zotto, Hwi Dong Yoo, Tilman Rohe, Sara Nabili, M. Bluj, Stephen Sanders, Seth Cooper, Lindsey Gray, D. Green, Zhiming Wang, Marek Gruchala, John Perry Cumalat, Swagata Mukherjee, Sung Keun Park, Abraham Tishelman-Charny, Stephen Wimpenny, Henning Flacher, Nikolaos Manthos, Toni Sculac, Todor Ivanov, E. J. Tonelli Manganote, Ekaterina Kuznetsova, Alberto Belloni, Piet Verwilligen, Robert Bainbridge, Inkyu Park, M. Ramirez-Garcia, Vincenzo Innocente, Silvia Maselli, Ioannis Papadopoulos, Jan Eysermans, Attilio Santocchia, Ivan Pozdnyakov, Ruchi Chudasama, Semra Turkcapar, Shin-Shan Yu, Linda Finco, Wenxing Fang, Geoffrey Hall, William Mcbrayer, G. N. Kim, Georgios Tsipolitis, Sanjay Padhi, Christian Laner, Martin Grunewald, J. Piedra Gomez, Marek Walczak, Wolfram Erdmann, Andrea Gelmi, J. M. 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Van Onsem, Efe Yazgan, Frank Hartmann, Luciano Orsini, Luca Pacher, Claire Shepherd-Themistocleous, Michael Wassmer, Antonis Agapitos, Thi Hien Doan, Daniel Denegri, Magda Diamantopoulou, Hartmut Stadie, Costas Foudas, Devdatta Majumder, C. A. Salazar González, Dominique Gigi, Jingzhou Zhao, Branislav Ristic, B. Chazin Quero, Luigi Guiducci, Gregory R Snow, Tamas Ferenc Csorgo, Paolo Checchia, Alberto Messineo, John Almond, Andreas Pfeiffer, Alessandra Cappati, Kreso Kadija, Petra Merkel, De Hua Zhu, Si Xie, Efstathios Paganis, R. Frühwirth, Erica Brondolin, K. W. Bell, Nataliia Kovalchuk, Mingshui Chen, Gobinda Majumder, Alain Givernaud, H. Rejeb Sfar, Jane Nachtman, Hyunyong Kim, Robert Stone, Mauro Emanuele Dinardo, Carmen Albajar, Sven Dildick, Nhan Viet Tran, Mohammad Abrar Wadud, Christof Roland, Marco Rovere, John Strologas, Sergio F Novaes, Brian Dorney, J. Fernandez Menendez, Charles Maguire, Marco Toliman Lucchini, Kirill Skovpen, Gregor Mittag, Rajat Gupta, Mara Senghi Soares, Serguei Ganjour, Marguerite Tonjes, Mariarosaria D'Alfonso, Mario Galanti, A. B. Meyer, Burak Bilki, Dener De Souza Lemos, Panagiotis Kokkas, Dhanush Anil Hangal, Silvia Taroni, Maria Giulia Ratti, S. K. Pflitsch, Igor Volobouev, David Colling, Amina Zghiche, Emily MacDonald, Özlem Özçelik, Niels Dupont, Andreas Hinzmann, Zhengcheng Tao, Gy L. Bencze, Marcin Konecki, Danilo Meuser, Andrew Gilbert, Ridhi Chawla, Artur Lobanov, Nathaniel Pastika, Kyle Tos, Samet Lezki, Didier Contardo, Zoltan Szillasi, Jussi Viinikainen, Nicholas Eminizer, R. Taus, Nicolò Trevisani, Dirk Krücker, Gianluca Cerminara, S. Tkaczyk, Lorenzo Russo, Edoardo Bossini, Maria Savina, F. Rezaei Hosseinabadi, Andrey Uzunian, Morgan Lethuillier, Yasar Onel, Ioannis Evangelou, Geonhee Oh, C. K. Mackay, J. Seixas, Daniele Ruini, Michail Bachtis, Pedro Silva, Regina Demina, Alberto Ruiz-Jimeno, Natascha Krammer, S. J. Qian, F. Gasparini, Martti Raidal, Pamela Klabbers, Meenakshi Narain, Burin Asavapibhop, Xunwu Zuo, Amedeo Staiano, Mauricio Thiel, Ilya Gorbunov, Reyer Band, Raffaello D'Alessandro, Matthias Komm, Arnab Purohit, Andrei Sobol, Christopher Palmer, Alice Bean, Balazs Ujvari, David Mark Raymond, Olivier Bondu, Jennifer Chu, J. H. Kim, J. R. González Fernández, Natalia Emriskova, E. O. Olaiya, Christophe Delaere, J. M. Hernandez, Giovanni Petrucciani, Simona Cometti, Scott Thomas, Edward Laird, Aurore Savoy-Navarro, Luca Mastrolorenzo, Sourabh Dube, Lisa Borgonovi, Mirena Ivova Paneva, David Stuart, Alice Mignerey, A. Benecke, Evgenii Tarkovskii, Stefanos Leontsinis, Thomas Eichhorn, Alessandro Thea, Isabel Pedraza, Paolo Azzurri, Chayanit Asawatangtrakuldee, Bennett Marsh, Duncan Carlsmith, Vieri Candelise, Ted Kolberg, C. Uribe Estrada, Muhammad Shoaib, H. Bakhshiansohi, Gabriella Pasztor, S. W. Lee, Emilien Chapon, Vittorio Raoul Tavolaro, I. O. Atakisi, A. A. Bin Anuar, Thorben Quast, J. Kaspar, Alex Kamenev, Victor Kim, Darien Wood, Damir Lelas, Willem Verbeke, Armando Lanaro, Jyothsna Rani Komaragiri, Dajeong Jeon, Ian Watson, Alexei Raspereza, Adel Terkulov, Caglar Zorbilmez, Peter Timothy Cox, Torben Lange, Gregor Kasieczka, Michael Mulhearn, Merve Ince, Shervin Nourbakhsh, Nicholas John Hadley, Jehad Mousa, Ignacio Redondo, Benjamin Stieger, Yurii Maravin, Karl Matthew Ecklund, Vladimir Gavrilov, H. Sert, M. R. Adams, S. Fonseca De Souza, Giuseppe Codispoti, M. Guchait, S. Afanasiev, A. Álvarez Fernández, J. D. Richman, Yannik Rath, James Bueghly, Matthew Nguyen, V. Rodríguez Bouza, Pedro G Mercadante, S. Belforte, Nabarun Dev, Johan Borg, Hans-Christian Kaestli, Clemens Wöhrmann, Claude Charlot, P. C. Tiwari, Reddy Pratap Gandrajula, Emrah Tiras, Toyoko Orimoto, Bolek Wyslouch, A. Rizzi, Giacomo Sguazzoni, Javier Duarte, Korbinian Schweiger, Anna Kropivnitskaya, Ibrahim Soner Zorbakir, V. Bunichev, Hongbo Liao, Aleko Khukhunaishvili, Stefano Marcellini, Sonaina Undleeb, Giuliana Galati, Daniel Bloch, Mohamed Rashad Darwish, Vivek Sharma, A. Bermúdez Martínez, Min Suk Kim, Jack King, R. Vidal, Paraskevas Gianneios, Predrag Cirkovic, Viola Sordini, T. R. Fernandez Perez Tomei, Erika Garutti, Y. Chao, Lesya Shchutska, Andrea Massironi, Raffaella Radogna, Giuseppe Barbagli, Viktor Khristenko, Jean-Baptiste Sauvan, Gigi Rolandi, Maria Spiropulu, Christian Dorfer, Salvatore Nuzzo, Markéta Jansová, Francesco Navarria, Sotiroulla Konstantinou, Simone Pigazzini, Giuseppe Benedetto Cerati, Stavros Mallios, James D. Olsen, Oliver Pooth, S. Slabospitskii, Narumon Suwonjandee, Spandan Mondal, A. C. Le Bihan, Etiennette Auffray, Maurizio Biasini, Kun Shi, Philippe Bloch, C. De Oliveira Martins, Martina Vit, Sh. Jain, G. L. Pinna Angioni, F. De Guio, Gaël Perrin, Andrew Carnes, Matthew Herndon, David Vannerom, Maral Alyari, Elisa Fontanesi, P. de Barbaro, Tahereh Sadat Niknejad, Jan Steggemann, Andrés Cabrera, Giuseppe Iaselli, Georgi Sultanov, R. M. Brown, James Keaveney, A. Richards, Hannes Jung, Mark Saunders, Alexander Zhokin, Hao Qiu, Thomas Schuh, D. R. Muller, Didar Dobur, Himal Acharya, S. Goy Lopez, A. Yagil, Sinan Sagir, Marta Felcini, Christopher George Tully, Yeonju Go, A. Vagnerini, Christophe Ochando, Vladimir Epshteyn, Francesco Santanastasio, Stoyan Stoynev, Thomas James, A. Sanchez-Hernandez, Daniel Marley, Sevgi Tekten, Umesh Joshi, Claudia Pistone, Ilya Kravchenko, Laurent Forthomme, Lorenzo Bianchini, Duje Giljanovic, Jovan Milosevic, Stefano Argiro, Alexander Belyaev, Martijn Mulders, A. Rose, S. Kaur, Claudio Campagnari, Teppo Mäenpää, N. V. Krasnikov, Maksym Titov, Daniel Klein, Stephanie Brandt, Pierluigi Paolucci, Aobo Zhang, M. G. Albrow, Claudio Caputo, J. S. 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Brochero Cifuentes, Simone Bologna, Yangyang Cheng, J. G. Branson, Georg Steinbrück, Arne Reimers, Douglas Berry, Andrea Bocci, Igor Azhgirey, Salvatore Buontempo, Maria Teresa Grippo, Gianni Zumerle, Anatoli Zarubin, Frank Golf, Joshua Bendavid, Nicanor Colino, Sihyun Jeon, Sunil Bansal, Pirmin Berger, Tommaso Dorigo, Sandra Malvezzi, W. L. Prado Da Silva, Kenichi Hatakeyama, Anna Woodard, Petr Levchenko, A. Vorobyev, E. E. Boos, Ruslan Chistov, Pietro Faccioli, D. H. Kim, Inseok Yoon, Doris Eckstein, Achim Geiser, Batoul Diab, Wenyu Zhang, Baokai Wang, Barbara Clerbaux, Marc Dejardin, Nikolai Golubev, M. Mohammadi Najafabadi, Isabel Ojalvo, Charles Harrington, Emil Sørensen Bols, Youn Roh, Georgy Antchev, Rostyslav Shevchenko, Patrick Asenov, M. Weber, Barry Blumenfeld, Emanuele Usai, T. V. Dimova, Nicholas Smith, Panja-Riina Luukka, C. Paus, Nikitas Loukas, Roberto Salerno, Scarlet Norberg, Olga Kodolova, Kadri Ozdemir, D. R. 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Cavallo, Po-Hsun Chen, Stefano Mersi, Mykyta Haranko, Imad Baptiste Laktineh, Lucas Taylor, Matthew Citron, G. De Lentdecker, R. G. Kellogg, Alexander Pauls, Lin Wang, Tom A. Williams, Ashfaq Ahmad, Ashim Roy, Radek Zlebcik, Shubham Pandey, Wei Shi, O. Rieger, Thomas Klijnsma, Debabrata Bhowmik, Adrian Perieanu, A. Meyer, Russell Richard Betts, Conor Henderson, Prasenjit Mal, Andrés G Delannoy, Christopher Hill, T. Kress, Susan Dittmer, Christina Snyder, Simon Regnard, Georgios Daskalakis, R. B. Garg, Christopher Seez, Jiajing Mao, Ada Solano, Sergei Gninenko, Virgil E Barnes, Andrzej Novak, Graham Wilson, Marcello Abbrescia, Th. Müller, Andre Frankenthal, Andreas Nowack, Mikhail Gavrilenko, W. S. Hou, Nadezda Chernyavskaya, Jan Krolikowski, Luiz Mundim, Duccio Abbaneo, D. Y. Wang, Tobias Pook, Emanuela Barberis, Jay Hauser, A. Vilela Pereira, Marco Cuffiani, B. McMaster, Michael Dittmar, Konstantin Matchev, J. J. 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M., Mason, D., Mcbride, P., Merkel, P., Mrenna, S., Nahn, S., O'Dell, V, Papadimitriou, V, Pedro, K., Pena, C., Rakness, G., Ravera, F., Ristori, L., Schneider, B., Sexton-Kennedy, E., Smith, N., Soha, A., Spalding, W. J., Spiegel, L., Stoynev, S., Strait, J., Strobbe, N., Taylor, L., Tkaczyk, S., Tran, N., V, Uplegger, L., Vaandering, E. W., Vernieri, C., Vidal, R., Wang, M., Weber, H. A., Acosta, D., Avery, P., Bourilkov, D., Brinkerhoff, A., Cadamuro, L., Carnes, A., Cherepanov, V, Errico, F., Field, R. D., Gleyzer, S., Joshi, B. M., Kim, M., Konigsberg, J., Korytov, A., Lo, K. H., Ma, P., Matchev, K., Menendez, N., Mitselmakher, G., Rosenzweig, D., Shi, K., Wang, J., Zuo, X., Joshi, Y. R., Adams, T., Askew, A., Hagopian, S., Hagopian, V, Johnson, K. F., Khurana, R., Kolberg, T., Martinez, G., Perry, T., Prosper, H., Schiber, C., Yohay, R., Zhang, J., Baarmand, M. M., Hohlmann, M., Noonan, D., Rahmani, M., Saunders, M., Yumiceva, F., Adams, M. R., Apanasevich, L., Betts, R. 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R., Mitchell, T., Modak, A., Mohammadi, A., Rebassoo, F., Wright, D., Baden, A., Baron, O., Belloni, A., Eno, S. C., Feng, Y., Hadley, N. J., Jabeen, S., Jeng, G. Y., Kellogg, R. G., Kunkle, J., Mignerey, A. C., Nabili, S., Ricci-Tam, F., Seidel, M., Shin, Y. H., Skuja, A., Tonwar, S. C., Wong, K., Abercrombie, D., Allen, B., Baty, A., Bi, R., Brandt, S., Busza, W., Cali, I. A., D'Alfonso, M., Ceballos, G. Gomez, Goncharov, M., Harris, P., Hsu, D., Hu, M., Klute, M., Kovalskyi, D., Lee, Y-J, Luckey, P. D., Maier, B., Marini, A. C., Mcginn, C., Mironov, C., Narayanan, S., Niu, X., Paus, C., Rankin, D., Roland, C., Roland, G., Shi, Z., Stephans, G. S. F., Sumorok, K., Tatar, K., Velicanu, D., Wang, T. W., Wyslouch, B., Chatterjee, R. M., Evans, A., Guts, S., Hansen, P., Hiltbrand, J., Jain, Sh, Kubota, Y., Lesko, Z., Mans, J., Revering, M., Rusack, R., Saradhy, R., Schroeder, N., Wadud, M. A., Acosta, J. G., Oliveros, S., Bloom, K., Claes, D. R., Fangmeier, C., Finco, L., Golf, F., Kamalieddin, R., Kravchenko, I, Siado, J. E., Snow, G. R., Stieger, B., Tabb, W., Agarwal, G., Harrington, C., Iashvili, I., Kharchilava, A., Mclean, C., Nguyen, D., Parker, A., Pekkanen, J., Rappoccio, S., Roozbahani, B., Alverson, G., Barberis, E., Freer, C., Haddad, Y., Hortiangtham, A., Madigan, G., Marzocchi, B., Morse, D. M., Orimoto, T., Skinnari, L., Tishelman-Charny, A., Wamorkar, T., Wang, B., Wisecarver, A., Wood, D., Bueghly, J., Gunter, T., Hahn, K. A., Odell, N., Schmitt, M. H., Sung, K., Trovato, M., Velasco, M., Bucci, R., Dev, N., Goldouzian, R., Hildreth, M., Anampa, K. Hurtado, Jessop, C., Karmgard, D. J., Lannon, K., Li, W., Loukas, N., Marinelli, N., Mcalister, I, Meng, F., Mueller, C., Planer, M., Ruchti, R., Siddireddy, P., Smith, G., Taroni, S., Wayne, M., Wightman, A., Wolf, M., Woodard, A., Alimena, J., Bylsma, B., Durkin, L. S., Francis, B., Hill, C., Ji, W., Lefeld, A., Ling, T. Y., Winer, B. L., Dezoort, G., Elmer, P., Hardenbrook, J., Haubrich, N., Higginbotham, S., Kalogeropoulos, A., Kwan, S., Lange, D., Lucchini, M. T., Luo, J., Marlow, D., Mei, K., Ojalvo, I, Olsen, J., Palmer, C., Pirou, P., Salfeld-Nebgen, J., Stickland, D., Tully, C., Norberg, S., Barker, A., Barnes, V. E., Gutay, L., Jones, M., Jung, A. W., Khatiwada, A., Mahakud, B., Miller, D. H., Negro, G., Neumeister, N., Peng, C. C., Piperov, S., Qiu, H., Schulte, J. F., Trevisani, N., Wang, F., Xiao, R., Xie, W., Cheng, T., Dolen, J., Parashar, N., Behrens, U., Ecklund, K. M., Freed, S., Geurts, F. J. M., Kilpatrick, M., Kumar, Arun, Padley, B. P., Redjimi, R., Roberts, J., Rorie, J., Shi, W., Leiton, A. G. Stahl, Tu, Z., Zhang, A., Bodek, A., de Barbaro, P., Demina, R., Dulemba, J. L., Fallon, C., Ferbel, T., Galanti, M., Garcia-Bellido, A., Hindrichs, O., Khukhunaishvili, A., Ranken, E., Taus, R., Chiarito, B., Chou, J. P., Gandrakota, A., Gershtein, Y., Halkiadakis, E., Hart, A., Heindl, M., Hughes, E., Kaplan, S., Laflotte, I, Lath, A., Montalvo, R., Nash, K., Osherson, M., Saka, H., Salur, S., Schnetzer, S., Somalwar, S., Stone, R., Thomas, S., Acharya, H., Delannoy, A. G., Spanier, S., Bouhali, O., Dalchenko, M., De Mattia, M., Delgado, A., Dildick, S., Eusebi, R., Gilmore, J., Huang, T., Luo, S., Malhotra, S., Marley, D., Mueller, R., Overton, D., Perni, L., Rathjens, D., Safonov, A., Akchurin, N., Damgov, J., De Guio, F., Kunori, S., Lamichhane, K., Mengke, T., Muthumuni, S., Peltola, T., Undleeb, S., Volobouev, I, Whitbeck, A., Greene, S., Gurrola, A., Janjam, R., Johns, W., Maguire, C., Melo, A., Ni, H., Padeken, K., Romeo, F., Sheldon, P., Tuo, S., Velkovska, J., Verweij, M., Arenton, M. W., Barria, P., Cox, B., Cummings, G., Hakala, J., Hirosky, R., Joyce, M., Ledovskoy, A., Neu, C., Tannenwald, B., Wolfe, E., Xia, F., Harr, R., Karchin, P. 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Bhubaneswar, Inst Phys, Shoolini Univ, Univ Hyderabad, Univ Visva Bharati, Isfahan Univ Technol, Italian Natl Agcy New Technol Energy & Sustainabl, Ctr Siciliano Fis Nucl & Struttura Mat, MOSTI, Consejo Nacl Ciencia & Technol, Warsaw Univ Technol, St Petersburg State Polytech Univ, Budker Inst Nucl Phys, Univ Siena, Stefan Meyer Inst Subatom Phys, Burdur Mehmet Akif Ersoy Univ, Adiyaman Univ, Sirnak Univ, Beykent Univ, Istanbul Aydin Univ, Mersin Univ, Piri Reis Univ, Gaziosmanpasa Univ, Ozyegin Univ, Izmir Inst Technol, Marmara Univ, Kafkas Univ, Istanbul Bilgi Univ, Hacettepe Univ, Univ Southampton, Univ Durham, Monash Univ, Bethel Univ, Karamanoglu Mehmetbey Univ, Bingol Univ, Sinop Univ, Mimar Sinan Univ, Texas A&M Univ Qatar, Department of Physics, Helsinki Institute of Physics, Eija Tuominen / Principal Investigator, Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Damarseçkin, Serdal, Candelise, V., DA ROLD, A., DELLA RICCA, G., ET AL (the CMS, Collaboration), Özdemir, Kadri, Sirunyan, A, Tumasyan, A, Adam, W, Ambrogi, F, Bergauer, T, Brandstetter, J, Dragicevic, M, Ero, J, Escalante Del Valle, A, Flechl, M, Fruhwirth, R, Jeitler, M, Krammer, N, Liko, D, Madlener, T, Rad, N, Schieck, J, Schofbeck, R, Spanring, M, Spitzbart, D, Waltenberger, W, Wulz, C, Zarucki, M, Suarez Gonzalez, J, Darwish, M, De Wolf, E, Di Croce, D, Janssen, X, Lelek, A, Pieters, M, Rejeb Sfar, H, Van Haevermaet, H, Van Mechelen, P, Van Putte, S, Van Remortel, N, Blekman, F, Bols, E, Chhibra, S, D'Hondt, J, De Clercq, J, Lontkovskyi, D, Lowette, S, Moortgat, S, Python, Q, Skovpen, K, Tavernier, S, Van Doninck, W, Van Mulders, P, Beghin, D, Bilin, B, Brun, H, Clerbaux, B, De Lentdecker, G, Delannoy, H, Dorney, B, Favart, L, Grebenyuk, A, Kalsi, A, Popov, A, Postiau, N, Starling, E, Thomas, L, Vander Velde, C, Vanlaer, P, Vannerom, D, Cornelis, T, Dobur, D, Niedziela, M, Roskas, C, Tytgat, M, Verbeke, W, Vermassen, B, Vit, M, Bondu, O, Bruno, G, Caputo, C, David, P, Delaere, C, Delcourt, M, Giammanco, A, Prisciandaro, J, Saggio, A, Vidal Marono, M, Vischia, P, Zobec, J, Alves, F, Alves, G, Correia Silva, G, Hensel, C, Moraes, A, Rebello Teles, P, Belchior Batista Das Chagas, E, Carvalho, W, Chinellato, J, Coelho, E, Da Costa, E, Da Silveira, G, De Jesus Damiao, D, De Oliveira Martins, C, Fonseca De Souza, S, Huertas Guativa, L, Malbouisson, H, Martins, J, Matos Figueiredo, D, Medina Jaime, M, Melo De Almeida, M, Mora Herrera, C, Mundim, L, Nogima, H, Prado Da Silva, W, Sanchez Rosas, L, Santoro, A, Sznajder, A, Thiel, M, Tonelli Manganote, E, Torres Da Silva De Araujo, F, Vilela Pereira, A, Bernardes, C, Calligaris, L, Fernandez Perez Tomei, T, Gregores, E, Lemos, D, Mercadante, P, Novaes, S, Padula, S, Aleksandrov, A, Antchev, G, Hadjiiska, R, Iaydjiev, P, Misheva, M, Rodozov, M, Shopova, M, Sultanov, G, Bonchev, M, Dimitrov, A, Ivanov, T, Litov, L, Pavlov, B, Petkov, P, Fang, W, Gao, X, Yuan, L, Ahmad, M, Hu, Z, Wang, Y, Chen, G, Chen, H, Chen, M, Jiang, C, Leggat, D, Liao, H, Liu, Z, Spiezia, A, Tao, J, Yazgan, E, Zhang, H, Zhang, S, Zhao, J, Agapitos, A, Ban, Y, Levin, A, Li, J, Li, L, Li, Q, Mao, Y, Qian, S, Wang, D, Wang, Q, Xiao, M, Avila, C, Cabrera, A, Florez, C, Gonzalez Hernandez, C, Segura Delgado, M, Mejia Guisao, J, Ruiz Alvarez, J, Salazar Gonzalez, C, Vanegas Arbelaez, N, Giljanovic, D, Godinovic, N, Lelas, D, Sculac, T, Antunovic, Z, Kovac, M, Ferencek, D, Kadija, K, Mesic, B, Roguljic, M, Starodumov, A, Susa, T, Ather, M, Attikis, A, Erodotou, E, Ioannou, A, Kolosova, M, Konstantinou, S, Mavromanolakis, G, Mousa, J, Nicolaou, C, Ptochos, F, Razis, P, Rykaczewski, H, Tsiakkouri, D, Finger, M, Kveton, A, Tomsa, J, Ayala, E, Carrera Jarrin, E, Abdalla, H, Elgammal, S, Bhowmik, S, Carvalho Antunes De Oliveira, A, Dewanjee, R, Ehataht, K, Kadastik, M, Raidal, M, Veelken, C, Eerola, P, Forthomme, L, Kirschenmann, H, Osterberg, K, Voutilainen, M, Garcia, F, Havukainen, J, Heikkila, J, Kim, M, Kinnunen, R, Lampen, T, Lassila-Perini, K, Laurila, S, Lehti, S, Linden, T, Luukka, P, Maenpaa, T, Siikonen, H, Tuominen, E, Tuominiemi, J, Tuuva, T, Besancon, M, Couderc, F, Dejardin, M, Denegri, D, Fabbro, B, Faure, J, Ferri, F, Ganjour, S, Givernaud, A, Gras, P, Hamel de Monchenault, G, Jarry, P, Leloup, C, Lenzi, B, Locci, E, Malcles, J, Rander, J, Rosowsky, A, Sahin, M, Savoy-Navarro, A, Titov, M, Ahuja, S, Amendola, C, Beaudette, F, Busson, P, Charlot, C, Diab, B, Falmagne, G, Granier de Cassagnac, R, Lobanov, A, Martin Perez, C, Nguyen, M, Ochando, C, Paganini, P, Rembser, J, Salerno, R, Sauvan, J, Sirois, Y, Zabi, A, Zghiche, A, Agram, J, Andrea, J, Bloch, D, Bourgatte, G, Brom, J, Chabert, E, Collard, C, Conte, E, Fontaine, J, Gele, D, Goerlach, U, Jansova, M, Le Bihan, A, Tonon, N, Van Hove, P, Gadrat, S, Beauceron, S, Bernet, C, Boudoul, G, Camen, C, Carle, A, Chanon, N, Chierici, R, Contardo, D, Depasse, P, El Mamouni, H, Fay, J, Gascon, S, Gouzevitch, M, Ille, B, Jain, S, Lagarde, F, Laktineh, I, Lattaud, H, Lesauvage, A, Lethuillier, M, Mirabito, L, Perries, S, Torterotot, L, Touquet, G, Vander Donckt, M, Viret, S, Khvedelidze, A, Tsamalaidze, Z, Autermann, C, Feld, L, Kiesel, M, Klein, K, Lipinski, M, Meuser, D, Pauls, A, Preuten, M, Rauch, M, Schulz, J, Teroerde, M, Wittmer, B, Erdmann, M, Fischer, B, Ghosh, S, Hebbeker, T, Hoepfner, K, Keller, H, Mastrolorenzo, L, Merschmeyer, M, Meyer, A, Millet, P, Mocellin, G, Mondal, S, Mukherjee, S, Noll, D, Novak, A, Pook, T, Pozdnyakov, A, Quast, T, Radziej, M, Rath, Y, Reithler, H, Roemer, J, Schmidt, A, Schuler, S, Sharma, A, Wiedenbeck, S, Zaleski, S, Flugge, G, Haj Ahmad, W, Hlushchenko, O, Kress, T, Muller, T, Nowack, A, Pistone, C, Pooth, O, Roy, D, Sert, H, Stahl, A, Aldaya Martin, M, Asmuss, P, Bakhshiansohi, H, Beernaert, K, Behnke, O, Bermudez Martinez, A, Bertsche, D, Bin Anuar, A, Borras, K, Campbell, A, Cardini, A, Connor, P, Consuegra Rodriguez, S, Contreras-Campana, C, De Wit, A, Defranchis, M, Diez Pardos, C, Dominguez Damiani, D, Eckerlin, G, Eckstein, D, Eichhorn, T, Elwood, A, Eren, E, Gallo, E, Geiser, A, Grohsjean, A, Guthoff, M, Haranko, M, Harb, A, Jafari, A, Jomhari, N, Jung, H, Kasem, A, Kasemann, M, Kaveh, H, Keaveney, J, Kleinwort, C, Knolle, J, Krucker, D, Lange, W, Lenz, T, Lidrych, J, Lipka, K, Lohmann, W, Mankel, R, Melzer-Pellmann, I, Meyer, M, Missiroli, M, Mittag, G, Mnich, J, Mussgiller, A, Perez Adan, D, Pflitsch, S, Pitzl, D, Raspereza, A, Saibel, A, Savitskyi, M, Schutze, P, Schwanenberger, C, Shevchenko, R, Singh, A, Tholen, H, Turkot, O, Vagnerini, A, Van De Klundert, M, Walsh, R, Wen, Y, Wichmann, K, Wissing, C, Zenaiev, O, Zlebcik, R, Aggleton, R, Bein, S, Benato, L, Benecke, A, Dreyer, T, Ebrahimi, A, Feindt, F, Frohlich, A, Garbers, C, Garutti, E, Gonzalez, D, Gunnellini, P, Haller, J, Hinzmann, A, Karavdina, A, Kasieczka, G, Klanner, R, Kogler, R, Kovalchuk, N, Kurz, S, Lange, J, Lange, T, Malara, A, Multhaup, J, Niemeyer, C, Perieanu, A, Reimers, A, Rieger, O, Scharf, C, Schleper, P, Schumann, S, Schwandt, J, Sonneveld, J, Stadie, H, Steinbruck, G, Stober, F, Vormwald, B, Akbiyik, M, Barth, C, Baselga, M, Baur, S, Berger, T, Butz, E, Caspart, R, Chwalek, T, De Boer, W, Dierlamm, A, El Morabit, K, Faltermann, N, Giffels, M, Goldenzweig, P, Gottmann, A, Harrendorf, M, Hartmann, F, Husemann, U, Kudella, S, Mitra, S, Mozer, M, Muller, D, Musich, M, Nurnberg, A, Quast, G, Rabbertz, K, Schroder, M, Simonis, H, Ulrich, R, Wassmer, M, Weber, M, Wohrmann, C, Wolf, R, Anagnostou, G, Asenov, P, Daskalakis, G, Geralis, T, Kyriakis, A, Loukas, D, Paspalaki, G, Diamantopoulou, M, Karathanasis, G, Kontaxakis, P, Manousakis-katsikakis, A, Panagiotou, A, Saoulidou, N, Stakia, A, Theofilatos, K, Vellidis, K, Vourliotis, E, Bakas, G, Kousouris, K, Tsipolitis, G, Foudas, C, Gianneios, P, 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M, Mondal, K, Nandan, S, Purohit, A, Rout, P, Saha, G, Sarkar, S, Sarkar, T, Sharan, M, Singh, B, Thakur, S, Behera, P, Kalbhor, P, Muhammad, A, Pujahari, P, Sikdar, A, Dutta, D, Mishra, D, Netrakanti, P, Pant, L, Shukla, P, Aziz, T, Bhat, M, Dugad, S, Mohanty, G, Sur, N, Verma, R, Banerjee, S, Chatterjee, S, Das, P, Guchait, M, Karmakar, S, Kumar, S, Majumder, G, Mazumdar, K, Sahoo, N, Sawant, S, Dube, S, Kansal, B, Kapoor, A, Kothekar, K, Pandey, S, Rane, A, Rastogi, A, Chenarani, S, Eskandari Tadavani, E, Etesami, S, Khakzad, M, Mohammadi Najafabadi, M, Naseri, M, Rezaei Hosseinabadi, F, Felcini, M, Grunewald, M, Abbrescia, M, Aly, R, Calabria, C, Colaleo, A, Creanza, D, Cristella, L, De Filippis, N, De Palma, M, Di Florio, A, Elmetenawee, W, Fiore, L, Gelmi, A, Iaselli, G, Ince, M, Lezki, S, Maggi, G, Maggi, M, Miniello, G, My, S, Nuzzo, S, Pompili, A, Pugliese, G, Radogna, R, Ranieri, A, Selvaggi, G, Silvestris, L, Simone, F, Venditti, R, Verwilligen, P, Abbiendi, G, Battilana, C, Bonacorsi, D, Borgonovi, L, Braibant-Giacomelli, S, Campanini, R, Capiluppi, P, Castro, A, Cavallo, F, Ciocca, C, Codispoti, G, Cuffiani, M, Dallavalle, G, Fabbri, F, Fanfani, A, Fontanesi, E, Giacomelli, P, Grandi, C, Guiducci, L, Iemmi, F, Lo Meo, S, Marcellini, S, Masetti, G, Navarria, F, Perrotta, A, Primavera, F, Rossi, A, Rovelli, T, Siroli, G, Tosi, N, Albergo, S, Costa, S, Di Mattia, A, Potenza, R, Tricomi, A, Tuve, C, Barbagli, G, Cassese, A, Ceccarelli, R, Civinini, C, D'Alessandro, R, Focardi, E, Latino, G, Lenzi, P, Meschini, M, Paoletti, S, Sguazzoni, G, Viliani, L, Benussi, L, Bianco, S, Piccolo, D, Bozzo, M, Ferro, F, Mulargia, R, Robutti, E, Tosi, S, Benaglia, A, Beschi, A, Brivio, F, Di Guida, S, Dinardo, M, Dini, P, Gennai, S, Ghezzi, A, Govoni, P, Guzzi, L, Malberti, M, Malvezzi, S, Menasce, D, Monti, F, Moroni, L, Paganoni, M, Pedrini, D, Ragazzi, S, Tabarelli de Fatis, T, Zuolo, D, Buontempo, S, Cavallo, N, De Iorio, A, Di Crescenzo, A, Fabozzi, F, Fienga, F, 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Cheng Y., Chu J., Datta A., Frankenthal A., Mcdermott K., Patterson J.R., Quach D., Ryd A., Tan S.M., Tao Z., Thom J., Wittich P., Zientek M., Abdullin S., Albrow M., Alyari M., Apollinari G., Apresyan A., Apyan A., Bauerdick L.A.T., Beretvas A., Berry D., Berryhill J., Bhat P.C., Burkett K., Butler J.N., Canepa A., Cerati G.B., Cheung H.W.K., Chlebana F., Cremonesi M., Duarte J., Elvira V.D., Freeman J., Gecse Z., Gottschalk E., Gray L., Green D., Grunendahl S., Gutsche O., Hall A.R., Hanlon J., Harris R.M., Hasegawa S., Heller R., Hirschauer J., Jayatilaka B., Jindariani S., Johnson M., Joshi U., Klijnsma T., Klima B., Kortelainen M.J., Kreis B., Lammel S., Lewis J., Lincoln D., Lipton R., Liu M., Liu T., Lykken J., Maeshima K., Marraffino J.M., Mason D., McBride P., Merkel P., Mrenna S., Nahn S., O'Dell V., Papadimitriou V., Pedro K., Pena C., Rakness G., Ravera F., Ristori L., Schneider B., Sexton-Kennedy E., Smith N., Soha A., Spalding W.J., Spiegel L., Stoynev S., Strait J., Strobbe N., Taylor L., Tkaczyk S., Tran N.V., Uplegger L., Vaandering E.W., Vernieri C., Vidal R., Wang M., Weber H.A., Acosta D., Avery P., Bourilkov D., Brinkerhoff A., Cadamuro L., Carnes A., Cherepanov V., Errico F., Field R.D., Gleyzer S.V., Joshi B.M., Kim M., Konigsberg J., Korytov A., Lo K.H., Ma P., Matchev K., Menendez N., Mitselmakher G., Rosenzweig D., Shi K., Wang J., Zuo X., Joshi Y.R., Adams T., Askew A., Hagopian S., Hagopian V., Johnson K.F., Khurana R., Kolberg T., Martinez G., Perry T., Prosper H., Schiber C., Yohay R., Zhang J., Baarmand M.M., Hohlmann M., Noonan D., Rahmani M., Saunders M., Yumiceva F., Adams M.R., Apanasevich L., Betts R.R., Cavanaugh R., Chen X., Dittmer S., Evdokimov O., Gerber C.E., Hangal D.A., Hofman D.J., Jung K., Mills C., Roy T., Tonjes M.B., Varelas N., Viinikainen J., Wang H., Wang X., Wu Z., Alhusseini M., Bilki B., Clarida W., Dilsiz K., Durgut S., Gandrajula R.P., Haytmyradov M., Khristenko V., Koseyan O.K., Merlo J.-P., Mestvirishvili A., Moeller A., Nachtman J., Ogul H., Onel Y., Ozok F., Penzo A., Snyder C., Tiras E., Wetzel J., Blumenfeld B., Cocoros A., Eminizer N., Gritsan A.V., Hung W.T., Kyriacou S., Maksimovic P., Roskes J., Swartz M., Baldenegro Barrera C., Baringer P., Bean A., Boren S., Bowen J., Bylinkin A., Isidori T., Khalil S., King J., Krintiras G., Kropivnitskaya A., Lindsey C., Majumder D., Mcbrayer W., Minafra N., Murray M., Rogan C., Royon C., Sanders S., Schmitz E., Tapia Takaki J.D., Williams J., Wilson G., Duric S., Ivanov A., Kaadze K., Kim D., Maravin Y., Mendis D.R., Mitchell T., Modak A., Mohammadi A., Rebassoo F., Wright D., Baden A., Baron O., Belloni A., Eno S.C., Feng Y., Hadley N.J., Jabeen S., Jeng G.Y., Kellogg R.G., Kunkle J., Mignerey A.C., Nabili S., Ricci-Tam F., Seidel M., Shin Y.H., Skuja A., Tonwar S.C., Wong K., Abercrombie D., Allen B., Baty A., Bi R., Brandt S., Busza W., Cali I.A., D'Alfonso M., Gomez Ceballos G., Goncharov M., Harris P., Hsu D., Hu M., Klute M., Kovalskyi D., Lee Y.-J., Luckey P.D., Maier B., Marini A.C., Mcginn C., Mironov C., Narayanan S., Niu X., Paus C., Rankin D., Roland C., Roland G., Shi Z., Stephans G.S.F., Sumorok K., Tatar K., Velicanu D., Wang T.W., Wyslouch B., Chatterjee R.M., Evans A., Guts S., Hansen P., Hiltbrand J., Kubota Y., Lesko Z., Mans J., Revering M., Rusack R., Saradhy R., Schroeder N., Wadud M.A., Acosta J.G., Oliveros S., Bloom K., Claes D.R., Fangmeier C., Finco L., Golf F., Kamalieddin R., Kravchenko I., Siado J.E., Snow G.R., Stieger B., Tabb W., Agarwal G., Harrington C., Iashvili I., Kharchilava A., McLean C., Nguyen D., Parker A., Pekkanen J., Rappoccio S., Roozbahani B., Alverson G., Barberis E., Freer C., Haddad Y., Hortiangtham A., Madigan G., Marzocchi B., Morse D.M., Orimoto T., Skinnari L., Tishelman-Charny A., Wamorkar T., Wang B., Wisecarver A., Wood D., Bueghly J., Gunter T., Hahn K.A., Odell N., Schmitt M.H., Sung K., Trovato M., Velasco M., Bucci R., Dev N., Goldouzian R., Hildreth M., Hurtado Anampa K., Jessop C., Karmgard D.J., Lannon K., Li W., Loukas N., Marinelli N., Mcalister I., Meng F., Mueller C., Musienko Y., Planer M., Ruchti R., Siddireddy P., Smith G., Taroni S., Wayne M., Wightman A., Wolf M., Woodard A., Alimena J., Bylsma B., Durkin L.S., Francis B., Hill C., Ji W., Lefeld A., Ling T.Y., Winer B.L., Dezoort G., Elmer P., Hardenbrook J., Haubrich N., Higginbotham S., Kalogeropoulos A., Kwan S., Lange D., Lucchini M.T., Luo J., Marlow D., Mei K., Ojalvo I., Olsen J., Palmer C., Piroue P., Salfeld-Nebgen J., Stickland D., Tully C., Norberg S., Barker A., Barnes V.E., Das S., Gutay L., Jones M., Jung A.W., Khatiwada A., Mahakud B., Miller D.H., Negro G., Neumeister N., Peng C.C., Piperov S., Qiu H., Schulte J.F., Trevisani N., Wang F., Xiao R., Xie W., Cheng T., Dolen J., Parashar N., Behrens U., Ecklund K.M., Freed S., Geurts F.J.M., Kilpatrick M., Padley B.P., Redjimi R., Roberts J., Rorie J., Shi W., Stahl Leiton A.G., Tu Z., Zhang A., Bodek A., de Barbaro P., Demina R., Dulemba J.L., Fallon C., Ferbel T., Galanti M., Garcia-Bellido A., Hindrichs O., Khukhunaishvili A., Ranken E., Taus R., Chiarito B., Chou J.P., Gandrakota A., Gershtein Y., Halkiadakis E., Hart A., Heindl M., Hughes E., Kaplan S., Laflotte I., Lath A., Montalvo R., Nash K., Osherson M., Saka H., Salur S., Schnetzer S., Somalwar S., Stone R., Thomas S., Acharya H., Delannoy A.G., Spanier S., Bouhali O., Dalchenko M., De Mattia M., Delgado A., Dildick S., Eusebi R., Gilmore J., Huang T., Kamon T., Luo S., Malhotra S., Marley D., Mueller R., Overton D., Pernie L., Rathjens D., Safonov A., Akchurin N., Damgov J., De Guio F., Kunori S., Lamichhane K., Mengke T., Muthumuni S., Peltola T., Undleeb S., Volobouev I., Whitbeck A., Greene S., Gurrola A., Janjam R., Johns W., Maguire C., Melo A., Ni H., Padeken K., Romeo F., Sheldon P., Tuo S., Velkovska J., Verweij M., Arenton M.W., Barria P., Cox B., Cummings G., Hakala J., Hirosky R., Joyce M., Ledovskoy A., Neu C., Tannenwald B., Wolfe E., Xia F., Harr R., Karchin P.E., Poudyal N., Sturdy J., Thapa P., Bose T., Buchanan J., Caillol C., Carlsmith D., Dasu S., De Bruyn I., Dodd L., Fiori F., Galloni C., He H., Herndon M., Herve A., Hussain U., Klabbers P., Lanaro A., Loeliger A., Long K., Loveless R., Madhusudanan Sreekala J., Pinna D., Ruggles T., Savin A., Smith W.H., Teague D., Trembath-reichert S., and Woods N.
Subjects: Top quark, associated production [Higgs particle], ComputerSystemsOrganization_COMPUTERSYSTEMIMPLEMENTATION, Physics::Instrumentation and Detectors, 13000 GeV-cms, Jet (particle physics), 01 natural sciences, High Energy Physics - Experiment, Physics, Particles & Fields, High Energy Physics - Experiment (hep-ex), S064HGC, Hadron-Hadron scattering (experiments), scattering [p p], PROGRAM, ComputingMilieux_COMPUTERSANDEDUCATION, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Higgs particle: mass: lower limit, Beyond Standard Model, Higgs physics, PLUS PLUS, Boson, Physics, 0105 Mathematical Physics, Large Hadron Collider, doublet [Higgs particle], CMS, 4. Education, Settore FIS/01 - Fisica Sperimentale, mass: lower limit [Higgs particle], Nuclear & Particles Physics, supersymmetry: minimal, channel cross section: branching ratio: upper limit, 3. Good health, CERN LHC Coll, Physical Sciences, 0202 Atomic, Molecular, Nuclear, Particle and Plasma Physics, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Higgs boson, PARTICLE PHYSICS, charged particle [Higgs particle], colliding beams [p p], Higgs, physics, PAIR PRODUCTION, MASSES, MODEL, HDECAY, MSSM, Particle Physics - Experiment, High energy physics, Experimental particle physics, LHC, Particle Physics Experiments, Vector boson scattering, Supersymmetry, Particle and resonance production, B physics, Particle correlations and fluctuations, Quarkonium, Elementary Particles and Fields, Jets, QCD, Top physics, Diboson, Electroweak, CKM matrix, Large detector-systems performance, Pattern recognition, p p: scattering, Nuclear and High Energy Physics, Particle physics, +top+bottom%22">Higgs particle --> top bottom, Higgs particle: charged particle, FOS: Physical sciences, 114 Physical sciences, Bottom quark, Higgs particle: doublet, bottom, ((n)jet) [final state], 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, ddc:530, 010306 general physics, 0206 Quantum Physics, branching ratio: upper limit [channel cross section], Science & Technology, ComputingMilieux_THECOMPUTINGPROFESSION, LARGE HADRON COLLIDER, hep-ex, background, 010308 nuclear & particles physics, Branching fraction, High Energy Physics::Phenomenology, Higgs physic, Higgs particle: associated production, minimal [supersymmetry], Pair production, hadronic decay [Higgs particle], Higgs particle: hadronic decay, lcsh:QC770-798, High Energy Physics::Experiment, p p: colliding beams, experimental results
Abstract: The CMS collaboration: et al., A search for charged Higgs bosons (H±) decaying into a top and a bottom quark in the all-jet final state is presented. The analysis uses LHC proton-proton collision data recorded with the CMS detector in 2016 at √s = 13 TeV, corresponding to an integrated luminosity of 35.9 fb−1. No significant excess is observed above the expected background. Model-independent upper limits at 95% confidence level are set on the product of the H± production cross section and branching fraction in two scenarios. For production in association with a top quark, limits of 21.3 to 0.007 pb are obtained for H± masses in the range of 0.2 to 3 TeV. Combining this with a search in leptonic final states results in improved limits of 9.25 to 0.005 pb. The complementary s-channel production of an H± is investigated in the mass range of 0.8 to 3 TeV and the corresponding upper limits are 4.5 to 0.023 pb. These results are interpreted using different minimal supersymmetric extensions of the standard model., Individuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract Nos. 675440, 752730, and 765710 (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation a la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the “Excellence of Science — EOS” — be.h project n. 30820817; the Beijing Municipal Science & Technology Commission, No. Z191100007219010; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Deutsche Forschungsgemeinschaft (DFG) under Germany’s Excellence Strategy — EXC 2121 “Quantum Universe” — 390833306; the Lendulet (“Momentum”) Program and the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences, the New National Excellence Program UNKP, the NKFIA research grants 123842, 123959, 124845, 124850, 125105, 128713, 128786, and 129058 (Hungary); the Council of Science and Industrial Research, India; the HOMING PLUS program of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund, the Mobility Plus program of the Ministry of Science and Higher Education, the National Science Center (Poland), contracts Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, and 2015/19/B/ST2/02861, Sonata-bis 2012/07/E/ST2/01406; the National Priorities Research Program by Qatar National Research Fund; the Ministry of Science and Education, grant no. 14.W03.31.0026 (Russia); the Programa Estatal de Fomento de la Investigacion Cientifica y Tecnica de Excelencia Maria de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias; the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); the Kavli Foundation; the Nvidia Corporation; the SuperMicro Corporation; the Welch Foundation, contract C-1845; and the Weston Havens Foundation (U.S.A.)., Article funded by SCOAP3.
Published: 2020
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17. Recommended nuclear data for medical radioisotope production: diagnostic gamma emitters

Author: F. T. Tárkányi, A. V. Ignatyuk, A. Hermanne, R. Capote, B. V. Carlson, J. W. Engle, M. A. Kellett, T. Kibedi, G. N. Kim, F. G. Kondev, M. Hussain, O. Lebeda, A. Luca, Y. Nagai, H. Naik, A. L. Nichols, F. M. Nortier, S. V. Suryanarayana, S. Takács, M. Verpelli, Vriendenkring VUB, Brussels Photonics Team, and Applied Physics and Photonics
Subjects: Padé fit, 010308 nuclear & particles physics, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, γ-ray emitters, Recommended σ- and yield data, Uncertainty estimation, IAEA Coordinated Research Project, 01 natural sciences, Pollution, Diagnostic medical isotopes, Analytical Chemistry, Cross-section evaluation, Nuclear Energy and Engineering, Radiology Nuclear Medicine and imaging, 0103 physical sciences, Radiology, Nuclear Medicine and imaging, 010306 general physics, Spectroscopy
Abstract: An extensive series of evaluations have been performed as part of an IAEA coordinated research project to study a set of nuclear reactions that produce the diagnostic gamma-ray emitting radionuclides Cr-51, Tc-99m, In-111, I-123 and Tl-201. Recommended cross-section data in the form of excitation functions have been derived, along with quantifications of their uncertainties. These evaluations involved the compilation of all previously published values and newly measured experimental data, followed by critical assessments and selection of those experimental datasets and accompanying uncertainties judged to be fully valid and statistically consistent for model-independent least-squares fitting by means of Pade approximations. Integral yields as a function of the energy were also calculated on the basis of the recommended cross sections deduced from these various fits. All evaluated numerical results and their corresponding uncertainties are available online at www-nds.iaea.org/medical/gamma_emitters.html and also on the medical portal of the International Atomic Energy Agency/Nuclear Data Section (IAEA-NDS) www-nds.iaea.org/medportal/.
Published: 2018

18. Production routes of 107,109Cd radioisotopes via charged particle induced nuclear reactions

Author: J. Csikai, Ferenc Tarkanyi, Md. Shuza Uddin, Alex Hermanne, Sandor Takacs, Ferenc Ditrói, Mamoru Baba, Vriendenkring VUB, Brussels Photonics Team, and Applied Physics and Photonics
Subjects: Nuclear reaction, Materials science, Proton, Nuclear reaction model code, Health, Toxicology and Mutagenesis, chemistry.chemical_element, Proton, deuteron, He and He irradiations, 010403 inorganic & nuclear chemistry, 01 natural sciences, Analytical Chemistry, 0103 physical sciences, Radiology, Nuclear Medicine and imaging, Irradiation, Spectroscopy, Physical yield, 010308 nuclear & particles physics, Radiochemistry, Public Health, Environmental and Occupational Health, Alpha particle, Pollution, Charged particle, CD, 0104 chemical sciences, Nuclear Energy and Engineering, chemistry, Deuterium, Radiology Nuclear Medicine and imaging, medical radioisotopes, Indium, Palladium
Abstract: Activation cross sections of application related Cd-107 and Cd-109 via proton, deuteron, alpha particle induced reactions on palladium, He-3 and alpha particle induced nuclear reactions on silver and deuteron induced reactions on cadmium and indium were measured by using the stacked foil irradiation technique and gamma-ray spectrometry. The cross sections were compared with the earlier experimental data and theoretical predictions. Integral yields were deduced on the basis of experimental data. Different production routes for both radioisotopes are compared.
Published: 2018

19. Correction to: iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy

Author: Wesley de Jong, Joeri Aerts, Sabine Allard, Christian Brander, Jozefien Buyze, Eric Florence, Eric van Gorp, Guido Vanham, Lorna Leal, Beatriz Mothe, Kris Thielemans, Montse Plana, Félipe Garcia, Rob Gruters, on behalf of the iHIVARNA consortium, Pharmaceutical and Pharmacological Sciences, Laboratory of Molecullar and Cellular Therapy, Clinical sciences, Internal Medicine, Pathologic Biochemistry and Physiology, Vriendenkring VUB, and Basic (bio-) Medical Sciences
Subjects: Anti-HIV Agents, T-Lymphocytes, Medicine (miscellaneous), HIV Infections, immunogenicity, Lymphocyte Activation, Study Protocol, Double-Blind Method, Humans, Antigen-presenting cell, Pharmacology (medical), RNA, Messenger, Reservoir, AIDS Vaccines, Medicine(all), lcsh:R5-920, Vaccination, Correction, HIV, Functional cure, Dendritic Cells, Therapeutic vaccine, Antiretroviral therapy, Chronic Disease, HIV-1, placebo, iHIVARNA Phase IIa, Lymph node, Immunotherapy, lcsh:Medicine (General), TriMix
Abstract: Background HIV therapeutic vaccination aims to improve the immune responses against HIV in order to control viral replication without the need for combined antiretroviral therapy (cART). iHIVARNA-01 is a novel vaccine combining mRNA delivery and T-cell immunogen (HTI) based on conserved targets of effective antiviral T-cell responses. In addition, it holds adequate stimuli required for activating antigen presenting cells (APC)s and co-activating specific T-cells (TriMix), including human CD40L, constitutively active TLR4 (caTLR4) and CD70. We propose that in-vivo targeting of dendritic cells (DCs) by direct administration of a HIV mRNA encoding these immune modulating proteins might be an attractive alternative to target DCs in vitro. Methods/design This is a phase-IIa, randomized, double-blinded, placebo-controlled, multicenter study in chronically HIV-1 infected patients under stable cART. One of the three study arms is randomly allocated to subjects. Three vaccinations with either HIVACAT T-cell immunogen (HTI)-TriMix (iHIVARNA-01), TriMix or water for injection (WFI) (weeks 0, 2 and 4) are administered by intranodal injection in the inguinal region. Two weeks after the last immunization (week 6) cART is stopped for 12 weeks. The two primary endpoints are: (1) safety and tolerability of intranodal iHIVARNA-01 vaccination compared with TriMix or WFI and (2) induced immunogenicity, i.e., increase in the frequency of HIV-specific T-cell responses between baseline, week 6 and 12 weeks after treatment interruption in iHIVARNA-01-treated patients as compared to the control groups, immunized with TriMix-mRNA or WFI measured by an IFNγ ELISPOT assay. Secondary endpoints include the evaluation of time to viral rebound, plasma viral load (pVL) at w18, the proportion of patients with control of viral load, induction of T-cell responses to new HIV epitopes, polyfunctionality of HIV-specific T-cells, CD8+ T-cell in-vitro HIV suppressive capacity, the effect on viral reservoir (measured by proviral DNA and cell-associated RNA), assessment of viral immune escape by mutation and mRNA expression profiles of host immune genes. Discussion This trial aims to direct target DC in situ with mRNA encoding HTI and TriMix for co-stimulation. Intranodal injection circumvents laborious DC isolation and handling in the laboratory. The trial extends on the safety results of a phase-I dose-escalating trial. This candidate vaccine could complement or even replace cART for chronic HIV infection and could be applicable to improve the care and cost of HIV infection. Trial registration EudraCT 2016-002724-83 (22 September 2016); ClinicalTrials.gov, ID: NCT02888756. Registered on 23 August 2016. Electronic supplementary material The online version of this article (10.1186/s13063-019-3409-1) contains supplementary material, which is available to authorized users.
Published: 2019

20. Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

Author: Vera Rogiers, Agapios Sachinidis, Umesh Chaudhari, Pieter Annaert, René P. Zahedi, Albert Sickmann, Xiaoqi Jiang, Marlies Oorts, Hector C. Keun, Eva Gijbels, Laxmikanth Kollipara, Eef Hoeben, Annette Kopp-Schneider, Jan G. Hengstler, Mathieu Vinken, Joery De Kock, Tamara Vanhaecke, Robim Marcelino Rodrigues, Pharmaceutical and Pharmacological Sciences, Faculty of Medicine and Pharmacy, Experimental in vitro toxicology and dermato-cosmetology, Connexin Signalling Research Group, Vriendenkring VUB, and Liver Connexin and Pannexin Research Group
Subjects: Proteomics, 0301 basic medicine, Health, Toxicology and Mutagenesis, Receptors, Cytoplasmic and Nuclear, Pharmacology, Toxicology, HEPATOCYTES, transcriptomics, 0302 clinical medicine, ATP Binding Cassette Transporter, Subfamily B, Member 11, Liver injury, BILE-ACIDS, Cholestasis, Bile acid, SAMPLE PREPARATION, General Medicine, adverse outcome pathway, Liver, BSEP, 030220 oncology & carcinogenesis, LIVER-INJURY, HepaRG, Life Sciences & Biomedicine, FARNESOID-X-RECEPTOR, medicine.drug, Cell Survival, medicine.drug_class, Adverse outcome pathway, INHIBITION, Biology, Article, MECHANISMS, Bile Acids and Salts, 03 medical and health sciences, Metabolomics, Cell Line, Tumor, medicine, Humans, dverse outcome pathway, Transcriptomics, Science & Technology, IDENTIFICATION, Dose-Response Relationship, Drug, DRUG-INDUCED CHOLESTASIS, Gene Expression Profiling, Bosentan, medicine.disease, Bile Salt Export Pump, SALT EXPORT PUMP, Oxidative Stress, 030104 developmental biology, 1115 Pharmacology And Pharmaceutical Sciences, Farnesoid X receptor, cholestasis, Transcriptome
Abstract: Bosentan is well known to induce cholestatic liver toxicity in humans. The present study was set up to characterize the hepatotoxic effects of this drug at the transcriptomic, proteomic, and metabolomic levels. For this purpose, human hepatoma-derived HepaRG cells were exposed to a number of concentrations of bosentan during different periods of time. Bosentan was found to functionally and transcriptionally suppress the bile salt export pump as well as to alter bile acid levels. Pathway analysis of both transcriptomics and proteomics data identified cholestasis as a major toxicological event. Transcriptomics results further showed several gene changes related to the activation of the nuclear farnesoid X receptor. Induction of oxidative stress and inflammation were also observed. Metabolomics analysis indicated changes in the abundance of specific endogenous metabolites related to mitochondrial impairment. The outcome of this study may assist in the further optimization of adverse outcome pathway constructs that mechanistically describe the processes involved in cholestatic liver injury. ispartof: ARCHIVES OF TOXICOLOGY vol:92 issue:6 pages:1939-1952 ispartof: location:Germany status: published
Published: 2018

21. SLC30A8 polymorphism and BMI complement HLA-A*24 as risk factors for poor graft function in islet allograft recipients

Author: Robert Hilbrands, Zhidong Ling, Frans Gorus, Bart Keymeulen, Bart Van Der Auwera, Pieter Gillard, Else M. Balke, DaHae Lee, Ursule Van de Velde, Bart O. Roep, Simke Demeester, Daniel Pipeleers, Pathology/molecular and cellular medicine, Faculty of Medicine and Pharmacy, Diabetes Pathology & Therapy, Clinical Biology, Diabetes Clinic, Public Health Sciences, and Vriendenkring VUB
Subjects: Blood Glucose, Male, 0301 basic medicine, Multivariate analysis, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Islets of Langerhans Transplantation, HLA-A24 Antigen, Zinc transporter 8, Gastroenterology, 0302 clinical medicine, Risk Factors, Insulin-Secreting Cells, Insulin, Medicine, Body mass index, Clinical Trials as Topic, geography.geographical_feature_category, SLC30A8, biology, Immunosuppression, Middle Aged, Allografts, Islet, 3. Good health, Treatment Outcome, Cohort, Female, medicine.medical_specialty, 030209 endocrinology & metabolism, HLAclass I, Human islet transplantation, 03 medical and health sciences, Internal medicine, Internal Medicine, Humans, Hypoglycemic Agents, Allele, Retrospective Studies, geography, Polymorphism, Genetic, business.industry, HLA class I, Recovery of Function, Transplantation, Diabetes Mellitus, Type 1, 030104 developmental biology, Genetics of type 1 diabetes, biology.protein, business, Biomarkers
Abstract: Aims/hypothesis: HLA-A*24 carriership hampers achievement of insulin independence in islet allograft recipients. However, less than half of those who fail to achieve insulin independence carry the allele. We investigated whether genetic polymorphism at the recipients’ zinc transporter 8-encoding SLC30A8 gene (rs13266634) could complement their HLA-A*24 status in predicting functional graft outcome. Methods: We retrospectively analysed data of a hospital-based patient cohort followed for 18 months post transplantation. Forty C-peptide-negative type 1 diabetic individuals who received >2 million beta cells (>4000 islet equivalents) per kg body weight in one or two intraportal implantations under similar immunosuppression were genotyped for SLC30A8. Outcome measurements included achievement and maintenance of graft function. Metabolic benefit was defined as 331 pmol/l C-peptide, in addition to achievement of insulin independence and maintenance of C-peptide positivity. Results: In multivariate analysis, HLA-A*24 positivity, presence of SLC30A8 CT or TT genotypes and BMI more than or equal to the group median (23.9 kg/m 2) were independently associated with failure to achieve insulin independence (p = 0.015–0.046). The risk increased with the number of factors present (p < 0.001). High BMI interacted with SLC30A8 T allele carriership to independently predict difficulty in achieving graft function with metabolic benefit (p = 0.015). Maintenance of C-peptide positivity was mainly associated with older age at the time of implantation. Only HLA-A*24 carriership independently predicted failure to maintain acceptable graft function once achieved (p = 0.012). Conclusions/interpretation: HLA-A*24, the SLC30A8 T allele and high BMI are associated with poor graft outcome and should be considered in the interpretation of future transplantation trials. Trial registration: ClinicalTrials.gov NCT00798785 and NCT00623610.
Published: 2018

22. A novel LIPS assay for insulin autoantibodies

Author: Frans Gorus, Elena Bazzigaluppi, Cristina Brigatti, Vito Lampasona, Peter Achenbach, Ilaria Marzinotto, Daniela Liberati, Ilse Weets, Emanuele Bosi, Eric V. Balti, Rebecca Wyatt, Alistair J K Williams, Ben Gillard, Maurizio Ferrari, Kathleen M Gillespie, Lorenzo Piemonti, Liberati, Daniela, Wyatt, Rebecca C., Brigatti, Cristina, Marzinotto, Ilaria, Ferrari, Maurizio, Bazzigaluppi, Elena, Bosi, Emanuele, Gillard, Ben T., Gillespie, Kathleen M., Gorus, Fran, Weets, Ilse, Balti, Eric, Piemonti, Lorenzo, Achenbach, Peter, Williams, Alistair J. K., Lampasona, Vito, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Vriendenkring VUB, Clinical Biology, Faculty of Medicine and Pharmacy, and Internal Medicine
Subjects: 0301 basic medicine, medicine.medical_specialty, Insulin Antibodies, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, medicine.disease_cause, Sensitivity and Specificity, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Antigen, Predictive Value of Tests, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Immunoprecipitation, Insulin, Child, Luciferases, Fluorescent Dyes, Autoantibodies, Proinsulin, Immunoassay, Type 1 diabetes, medicine.diagnostic_test, business.industry, Autoantibody, General Medicine, Prognosis, medicine.disease, Autoantibodie, Diabetes Mellitus, Type 1, HEK293 Cells, 030104 developmental biology, Case-Control Studies, T1D, LIPS, Prediction, business, Biomarkers
Abstract: Aims: Insulin autoantibodies (IAA) are often the first marker of autoimmunity detected in children in the preclinical phase of type 1 diabetes (T1D). Currently, the vast majority of laboratories adopt the radiobinding micro-assay (RBA) for measuring IAA. Our aim was to replace RBA with a novel non-radioactive IAA Luciferase Immuno Precipitation System (LIPS) assay with improved performance. Methods: We developed (pro)insulin antigens with alternative placements of a NanoLuc™ luciferase reporter (NLuc). Performance in LIPS was evaluated by testing sera from new onset T1D (n = 80), blood donors (n = 123), schoolchildren (n = 186), first-degree relatives (FDRs) from the Bart’s Oxford family study (n = 53) and from the Belgian Diabetes Registry (n = 136), coded sera from the Islet Autoantibody Standardization Program (IASP) (T1D n = 50, blood donors n = 90). Results: IAA LIPS based on B chain-NLuc proinsulin or B chain-NLuc insulin, in which NLuc was fused at the C-terminus of the insulin B chain, required only 2 μL of serum and a short incubation time, showed high concordance with RBA (Spearman r = 0.866 and 0.833, respectively), high assay performance (B chain-NLuc proinsulin ROC-AUC = 0.894 and B chain-NLuc insulin ROC-AUC = 0.916), and an adjusted sensitivity at 95% specificity ranking on par with the best assays submitted to the two most recent IASP workshops. In FDRs, the IAA LIPS showed improved discrimination of progressors to T1D compared to RBA. Conclusions: We established a novel high-performance non-radioactive IAA LIPS that might replace the current gold standard RBA and find wide application in the study of the IAA response in T1D.
Published: 2018

23. Activation cross sections of proton induced nuclear reactions on neodymium up to 65 MeV

Author: Alex Hermanne, Sandor Takacs, Fenyvesy Ditroi, Ferenc Tarkanyi, Vriendenkring VUB, Brussels Photonics Team, and Applied Physics and Photonics
Subjects: Nuclear reaction, Materials science, Proton, Proton irradiation, Health, Toxicology and Mutagenesis, FOS: Physical sciences, chemistry.chemical_element, 010403 inorganic & nuclear chemistry, 01 natural sciences, Neodymium, Analytical Chemistry, Nuclear physics, Pm, Nd, Pr, and Ce radioisotopes, 0103 physical sciences, Radiology, Nuclear Medicine and imaging, Nuclear Experiment (nucl-ex), Natural neodymium target, Nuclear Experiment, Spectroscopy, FOIL method, Physical yield, Radionuclide, Cross section, Isotope, 010308 nuclear & particles physics, Public Health, Environmental and Occupational Health, Pollution, Charged particle, 0104 chemical sciences, Nuclear Energy and Engineering, chemistry, Radiology Nuclear Medicine and imaging, Excitation
Abstract: In the frame of a systematic study of the activation cross sections of charged particle induced nuclear reactions on rare earths for production of therapeutic radionuclides, proton induced reactions on neodymium were measured up to 65 MeV energy, above 45 MeV for the first time. The excitation functions of the Nd-nat(p,x)Pm-150,Pm-149,Pm-148m,Pm-148g,Pm-146,Pm-144,Pm-143,Pm-141, Nd-149,Nd-147,Nd-141,Nd-140,Nd-139m,Nd-138, Pr-142,Pr-138m and Ce-139g nuclear reactions were assessed by using stacked foil activation technique and high resolution gamma-spectrometry. The excitation functions were compared to the theoretical predictions, available in the TENDL-2015 library based on latest version of the TALYS code. The application of the data for medical isotope production is shortly discussed.
Published: 2017

24. Activation cross section data of proton induced nuclear reactions on lanthanum in the 34–65 MeV energy range and application for production of medical radionuclides

Author: Fenyvesy Ditroi, Alex Hermanne, Sandor Takacs, Ferenc Tarkanyi, Applied Physics and Photonics, Brussels Photonics Team, and Vriendenkring VUB
Subjects: Nuclear reaction, Materials science, Proton, Theoretical model codes, Health, Toxicology and Mutagenesis, FOS: Physical sciences, chemistry.chemical_element, 010403 inorganic & nuclear chemistry, 01 natural sciences, 030218 nuclear medicine & medical imaging, Analytical Chemistry, 03 medical and health sciences, Cross section (physics), 0302 clinical medicine, Lanthanum, Radiology, Nuclear Medicine and imaging, Irradiation, Nuclear Experiment (nucl-ex), Proton irradiation of La target, Nuclear Experiment, Spectroscopy, FOIL method, Medical radionuclides, Physical yield, Radionuclide, Range (particle radiation), Cross section, Radiochemistry, Public Health, Environmental and Occupational Health, Pollution, Cerium, lanthanum and barium radionuclides, 0104 chemical sciences, Nuclear Energy and Engineering, chemistry, Radiology Nuclear Medicine and imaging
Abstract: Activation cross sections of the La-nat(p,x)Ce-139,Ce-137m,Ce-137g,Ce-135,Ce-134,Ce-133m, La-nat(p,x)La-135,La-134,La-133 and Ba-133m,Ba-133g,Ba-131 nuclear reactions have been measured experimentally, for the first time (except Ce-139). Cross-sections in the 34-64 MeV energy range were obtained through an activation method combining the stacked foil irradiation technique and gamma-ray spectrometry. The experimental cross sections were compared with the theoretical prediction in the TENDL-2014 and TENDL-2015, TALYS based libraries. Applications in the field of medical radionuclides production is discussed.
Published: 2017

25. Stepped water isotherm and breakthrough curves on aluminium fumarate metal–organic framework: experimental and modelling study

Author: Dirk De Vos, Belgin Bozbiyik, Tom Van Assche, Jeroen Lannoeye, Joeri Denayer, Gino Baron, Department of Bio-engineering Sciences, Faculty of Sciences and Bioengineering Sciences, Chemical Engineering and Industrial Chemistry, Faculty of Engineering, Vriendenkring VUB, Centre for Molecular Separation Science & Technology, Microreactortechnology, and Chemical Engineering and Separation Science
Subjects: Water adsorption, General Chemical Engineering, Adsorbent, chemistry.chemical_element, Thermodynamics, 02 engineering and technology, Low-Pressure, 010402 general chemistry, 01 natural sciences, Separation, Adsorption, Al-fumarate, Aluminium, MOF, Chromatography, Fixed bed, Surfaces and Interfaces, General Chemistry, Partial pressure, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, VAPOR, Heat Transformation, Gravimetric analysis, Metal-organic framework, Sorption isotherm, Breakthrough experiments, 0210 nano-technology, Stability, Water vapor
Abstract: Adsorption of water vapour on the Al-fumarate metal-organic framework (MOF) was studied in static and dynamic conditions, by performing gravimetric and fixed bed experiments. A two-step, type IV water isotherm is obtained, which reveals the complexity and the duality of the hydrophilic/hydrophobic behaviour of this MOF. Breakthrough experiments with feed conditions corresponding to three different zones in the water adsorption isotherm were performed to study the effect of isotherm shape on the column dynamics. At low partial pressure of water in the feed, a single breakthrough step is observed while a stepped profile is observed at higher partial pressure of water. These breakthrough curves could be described qualitatively with a simple model accounting for the isotherm shape.
Published: 2016

26. A vitamin D, calcium and leucine-enriched whey protein nutritional supplement improves measures of bone health in sarcopenic non-malnourished older adults: The PROVIDE study

Author: the PROVIDE Consortium, Hill, Tom R., Verlaan, Sjors, Biesheuvel, Egbert, Eastell, Richard, Bauer, Juergen M., Bautmans, Ivan, Brandt, Kirsten, Donini, Lorenzo M., Maggio, Marcello, Mets, Tony, Seal, Chris J., Wijers, Sander Lj, Sieber, Cornel, Cederholm, Tommy, Aspray, Terry J., Research in Geriatrics and Gerontology, Gerontology, Rehabilitation Research, Physical Medicine and Rehabilitation, Frailty in Ageing, Vriendenkring VUB, and Geriatrics
Subjects: 0301 basic medicine, Male, Aging, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Parathyroid hormone, Bone remodeling, Insulin-like growth factor, 0302 clinical medicine, Bone Density, Orthopedics and Sports Medicine, Vitamin D, intervention, Bone mineral, BMD, bone turnover, leucine, PROVIDE study, vitamin D, biology, Middle Aged, Micronutrient, Endokrinologi och diabetes, Osteocalcin, Female, PROVIDE Study, medicine.medical_specialty, Bone turnover, 030209 endocrinology & metabolism, Intervention, Endocrinology and Diabetes, Bone and Bones, 03 medical and health sciences, endocrinology, Double-Blind Method, Leucine, Internal medicine, medicine, Vitamin D and neurology, Humans, Muscle Strength, Muscle, Skeletal, Aged, business.industry, medicine.disease, Endocrinology, Whey Proteins, Sarcopenia, Dietary Supplements, biology.protein, Calcium, 030101 anatomy & morphology, business
Abstract: Alterations in musculoskeletal health with advanced age contribute to sarcopenia and decline in bone mineral density (BMD) and bone strength. This decline may be modifiable via dietary supplementation. To test the hypothesis that a specific oral nutritional supplement can result in improvements in measures of bone health. Participants (n 380) were participants of the PROVIDE study, a 13-week, multicenter, randomized, controlled, double-blind, 2 parallel-group study among non-malnourished older participants (≥ 65 years) with sarcopenia [determined by Short Physical Performance Battery (SPPB; 0-12) scores between 4 and 9, and a low skeletal muscle mass index (SMI; skeletal muscle mass/BW × 100) ≤ 37% in men and ≤ 28% in women using bioelectric impedance analysis] Supplementation of a vitamin D, calcium and leucine-enriched whey protein drink that comprises a full range of micronutrients (active; 2/day) was compared with an iso-caloric control. Serum 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), biochemical markers of bone formation (osteocalcin; OC, procollagen type 1 amino-terminal propeptide; P1NP) and resorption (carboxy-terminal collagen crosslinks; CTX), insulin like growth factor 1 (IGF-1) and total-body BMD were analysed pre- and post-intervention. Serum 25(OH)D concentrations increased from 51.1 ± 22.9 nmol/L (mean ± SD) to 78.9 ± 21.1 nmol/L in the active group (p
Published: 2019

27. Search for steady point-like sources in the astrophysical muon neutrino flux with 8 years of IceCube data

Author: IceCube Collaboration, Aartsen, M. G., Ansseau, I., Gonzalez, J. G., Grant, D., Griffith, Z., Haack, Christian, Hallgren, A., Halve, Lasse Yannik, Halzen, F., Hanson, K., Hebecker, D., Heereman, D., Anton, G., Helbing, K., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Hoinka, T., Hokanson-Fasig, B., Hoshina, K., Argüelles, C., Huang, F., Huber, M., Hultqvist, K., Hünnefeld, M., Hussain, R., In, S., Iovine, N., Ishihara, A., Jacobi, E., Japaridze, G. S., Auffenberg, Jan, Jeong, M., Jero, K., Jones, B. J. P., Kalaczynski, P., Kang, W., Kappes, A., Kappesser, D., Karg, T., Karle, A., Katz, U., Axani, S., Kauer, M., Keivani, A., Kelley, J. L., Kheirandish, A., Kim, J., Kintscher, T., Kiryluk, J., Kittler, T., Klein, S. R., Koirala, R., Backes, P., Kolanoski, H., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, M., Krückl, G., Kunwar, S., Bagherpour, H., Kurahashi, N., Kyriacou, A., Labare, M., Lanfranchi, J. L., Larson, M. J., Lauber, F., Leonard, K., Leuermann, Martin, Liu, Q. R., Lohfink, E., Bai, X., Lozano Mariscal, C. J., Lu, L., Lünemann, J., Luszczak, W., Madsen, J., Maggi, G., Mahn, K. B. M., Makino, Y., Mancina, S., Mariş, I. C., Barbano, A., Maruyama, R., Mase, K., Maunu, R., Meagher, K., Medici, M., Meier, M., Menne, T., Merino, G., Meures, T., Miarecki, S., Barron, J. P., Micallef, J., Momenté, G., Montaruli, T., Moore, R. W., Moulai, M., Nagai, R., Nahnhauer, R., Nakarmi, P., Naumann, U., Neer, G., Ackermann, M., Barwick, S. W., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke Pollmann, A., Olivas, A., O'Murchadha, A., O'Sullivan, E., Palczewski, T., Pandya, H., Pankova, D. V., Baum, V., Peiffer, P., Pérez de los Heros, C., Pieloth, D., Pinat, E., Pizzuto, A., Plum, M., Price, P. B., Przybylski, G. T., Raab, C., Raissi, A., Bay, R., Rameez, M., Rauch, L., Rawlins, K., Rea, I. C., Reimann, René, Relethford, B., Renzi, G., Resconi, E., Rhode, W., Richman, M., Beatty, J. J., Robertson, S., Rongen, Martin, Rott, C., Ruhe, T., Ryckbosch, D., Rysewyk, D., Safa, I., Sanchez Herrera, S. E., Sandrock, A., Sandroos, J., Becker Tjus, J., Santander, M., Sarkar, S., Satalecka, K., Schaufel, Merlin, Schlunder, P., Schmidt, T., Schneider, A., Schneider, J., Schöneberg, S., Becker, K.-H., Schumacher, Lisa Johanna, Sclafani, S., Seckel, D., Seunarine, S., Soedingrekso, J., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stachurska, J., BenZvi, S., Stamatikos, M., Stanev, T., Stasik, A., Stein, R., Stettner, Jöran Benjamin, Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Strotjohann, N. L., Berley, D., Stuttard, T., Sullivan, G. W., Sutherland, M., Taboada, I., Tenholt, F., Ter-Antonyan, S., Terliuk, A., Tilav, S., Tobin, M. N., Tönnis, C., Bernardini, E., Toscano, S., Tosi, D., Tselengidou, M., Tung, C. F., Turcati, A., Turcotte, R., Turley, C. F., Ty, B., Unger, E., Unland Elorrieta, M. A., Besson, D. Z., Usner, M., Vandenbroucke, J., Van Driessche, Ward, van Eijk, D., van Eijndhoven, N., Vanheule, S., van Santen, J., Vraeghe, M., Walck, C., Wallace, A., Adams, J., Binder, G., Wallraff, Marius, Wandler, F. D., Wandkowsky, N., Watson, T. B., Weaver, C., Weiss, M. J., Wendt, C., Werthebach, J., Westerhoff, S., Whelan, B. J., Bindig, D., Whitehorn, N., Wiebe, K., Wiebusch, Christopher, Wille, L., Williams, D. R., Wills, L., Wolf, M., Wood, J., Wood, T. R., Woolsey, E., Blaufuss, E., Woschnagg, K., Wrede, G., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., Yuan, T., Blot, S., Bohm, C., Börner, M., Bos, F., Böser, S., Botner, O., Bourbeau, E., Aguilar, J. A., Bourbeau, J., Bradascio, F., Braun, J., Bretz, H.-P., Bron, S., Brostean-Kaiser, J., Burgman, A., Busse, R. S., Carver, T., Chen, C., Ahlers, M., Cheung, E., Chirkin, D., Clark, K., Classen, L., Collin, G. H., Conrad, J. M., Coppin, P., Correa, P., Cowen, D. F., Cross, R., Ahrens, M., Dave, P., Day, M., de André, J. P. A. M., De Clercq, C., DeLaunay, J. J., Dembinski, H., Deoskar, K., De Ridder, S., Desiati, P., de Vries, K. D., Altmann, D., de Wasseige, G., de With, M., DeYoung, T., Díaz-Vélez, J. C., Dujmovic, H., Dunkman, M., Dvorak, E., Eberhardt, B., Ehrhardt, T., Eichmann, B., Andeen, K., Eller, P., Evenson, P. A., Fahey, S., Fazely, A. R., Felde, J., Filimonov, K., Finley, C., Franckowiak, A., Friedman, E., Fritz, A., Anderson, T., Gaisser, T. K., Gallagher, J., Ganster, Erik, Garrappa, S., Gerhardt, L., Ghorbani, K., Giang, W., Glauch, T., Glüsenkamp, T., Goldschmidt, A., Barbano, Anastasia, Bron, Stéphanie, Carver, Tessa, Montaruli, Teresa, Physics, Faculty of Sciences and Bioengineering Sciences, Vriendenkring VUB, and Elementary Particle Physics
Subjects: Physics and Astronomy (miscellaneous), Physics::Instrumentation and Detectors, Flux, PROPAGATION, 01 natural sciences, neutrino: flux, IceCube, ENERGY, Subatomär fysik, High Energy Physics - Phenomenology (hep-ph), Subatomic Physics, Muon neutrino, 010303 astronomy & astrophysics, media_common, High Energy Astrophysical Phenomena (astro-ph.HE), Physics, ddc, High Energy Physics - Phenomenology, Physique des particules élémentaires, Neutrino, Astrophysics - High Energy Astrophysical Phenomena, Particle physics, Astrophysics::High Energy Astrophysical Phenomena, media_common.quotation_subject, FOS: Physical sciences, lcsh:Astrophysics, ddc:500.2, Computer Science::Digital Libraries, blazar, muon, lcsh:QB460-466, 0103 physical sciences, lcsh:Nuclear and particle physics. Atomic energy. Radioactivity, ddc:530, Sensitivity (control systems), Blazar, Engineering (miscellaneous), background, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, flux [neutrino], sensitivity, Universe, CRAB-NEBULA, angular resolution, Physics and Astronomy, RESOLUTION, Sky, lcsh:QC770-798, High Energy Physics::Experiment, Energy (signal processing)
Abstract: The European physical journal / C 79(3), 234 (2019). doi:10.1140/epjc/s10052-019-6680-0, The IceCube Collaboration has observed a high-energy astrophysical neutrino flux and recently found evidence for neutrino emission from the blazar TXS 0506 $+$ 056. These results open a new window into the high-energy universe. However, the source or sources of most of the observed flux of astrophysical neutrinos remains uncertain. Here, a search for steady point-like neutrino sources is performed using an unbinned likelihood analysis. The method searches for a spatial accumulation of muon-neutrino events using the very high-statistics sample of about 497,000 neutrinos recorded by IceCube between 2009 and 2017. The median angular resolution is $\sim 1^\circ $ at 1 TeV and improves to $\sim 0.3^\circ $ for neutrinos with an energy of 1 PeV. Compared to previous analyses, this search is optimized for point-like neutrino emission with the same flux-characteristics as the observed astrophysical muon-neutrino flux and introduces an improved event-reconstruction and parametrization of the background. The result is an improvement in sensitivity to the muon-neutrino flux compared to the previous analysis of $\sim 35\%$ assuming an $E^{-2}$ spectrum. The sensitivity on the muon-neutrino flux is at a level of $E^2 \mathrm {d} N /\mathrm {d} E = 3\cdot 10^{-13}\,\mathrm {TeV}\,\mathrm {cm}^{-2}\,\mathrm {s}^{-1}$ . No new evidence for neutrino sources is found in a full sky scan and in an a priori candidate source list that is motivated by gamma-ray observations. Furthermore, no significant excesses above background are found from populations of sub-threshold sources. The implications of the non-observation for potential source classes are discussed., Published by Springer, Heidelberg
Published: 2019
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28. Modelled decomposition mechanism of flame retarded poly(vinyl acetate) by melamine isocyanurate

Author: Monique Biesemans, Serge Bourbigot, B. Van Mele, Hubert Rahier, Bart Rimez, Chemical Engineering and Industrial Chemistry, Materials and Chemistry, Physical Chemistry and Polymer Science, Vriendenkring VUB, and High Resolution NMR Centre
Subjects: Materials science, Melamine isocyanurate, Composite number, 02 engineering and technology, 010402 general chemistry, Solid-state NMR, 01 natural sciences, chemistry.chemical_compound, Poly(vinyl acetate), Polymer chemistry, Vinyl acetate, Char, TG–MS, Physical and Theoretical Chemistry, Intumescence, chemistry.chemical_classification, Polymer, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Degradation mechanism, Decomposition, 0104 chemical sciences, chemistry, Chemical engineering, 0210 nano-technology, Melamine, Intumescent, Fire retardant
Abstract: Model polymer poly(vinyl acetate) (PVAc) was combined with melamine isocyanurate (MIC) as intumescent flame retardant composite. This work emphasises on the study of the decomposition mechanism and compared with a single fire test in order to show its performance as flame retarded composite. As such, mass loss cone calorimetry tests were performed and compared with it inert and oxidative decompositions in lab tests. PVAc/MIC composites cannot be ignited with high loadings MIC. Difference curves in oxidative conditions revealed that the composites with MIC show only positive differences, indicating a high stabilisation, especially in the temperature region of a mild flame (500–700 °C). Experiments performed with TG coupled with mass spectroscopy and analyses on partially degraded residues with solid-state 13C-NMR enabled the construction of the complete decomposition mechanism. MIC has both a heat-sink FR activity as well as a crosslinking role in the stabilization of the polymer. The latter then creates a highly stabilised char at elevated temperatures in oxidative environments. The formed char starts to degrade only 100 °C higher than the pure polymer within a heating. The degradation of formed char of pure PVAc is autocatalytic; this behaviour disappears upon addition of sufficient amount of MIC. Therefore, the transport of fuel towards the gaseous phase is limited, creating an efficient flame retardant system.
Published: 2016

29. Congenital cytomegalovirus infection: contribution and best timing of prenatal MR imaging

Author: Roland Devlieger, T. Cos, Walter Foulon, Elise Van der Valk, Jacques Jani, Raymond Oyen, Mieke Cannie, Veerle Cossey, Ina Foulon, Filip Claus, Astrid Leus, Anja Bernaert, Luc De Catte, Mina Leyder, Supporting clinical sciences, Medical Imaging and Physical Sciences, Gyneacology-Urology, Surgical clinical sciences, Vriendenkring VUB, Mother and Child, Medical Imaging, and Microbiology and Infection Control
Subjects: Male, Fetal MRI, medicine.medical_specialty, Congenital CMV, Hearing Loss, Sensorineural, Cytomegalovirus, Gestational Age, Prenatal diagnosis, Ultrasonography, Prenatal, Polar temporal lesions, sensorineural hearing loss, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Pregnancy, Prenatal Diagnosis, otorhinolaryngologic diseases, medicine, Humans, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Neuroradiology, Medicine(all), 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Infant, Newborn, Brain, Infant, Gestational age, Magnetic resonance imaging, General Medicine, Prognosis, medicine.disease, Magnetic Resonance Imaging, Hyperintensity, Fetal Diseases, Fetal infection, Predictive value of tests, Cytomegalovirus Infections, Feasibility Studies, Female, Sensorineural hearing loss, Radiology, business, Follow-Up Studies
Abstract: OBJECTIVE: To predict sensorineural hearing loss (SNHL) and neurological impairment in congenital cytomegalovirus (cCMV) infection using MR imaging and define the best timing in pregnancy for prenatal assessment. METHODS: In 121 patients with confirmed cCMV infection, brain features at MR imaging were respectively graded from 1 to 5: normal; isolated frontal/parieto-occipital hyperintensity; temporal periventricular hyperintensity; temporal/occipital cysts and/or intraventricular septa; migration disorders. Grading was correlated with postnatal SNHL and neurological impairment using regression analysis. In 51 fetuses with MR examinations at 26.9 and 33.0 weeks, the predictive value of SNHL and neurological impairment was compared using ROC curves. RESULTS: Postnatal follow-up showed SNHL in 18 infants and neurological impairment in 10. MR grading was predictive of SNHL and of neurological impairment (P
Published: 2016

30. Measuring Strategic Hedging Capability of Second-Tier States Under Unipolarity

Author: Gustaaf Geeraerts, Mohammad Salman, Political Science, Dienst Marketing, Communicatie en Evenementen, Staf and Secretary, Brussels Institute for Contemporary China Studies, and Vriendenkring VUB
Subjects: Index (economics), Unipolarity, Sociology and Political Science, Financial economics, 05 social sciences, Government debt, Strategic Hedging Capability Index, Sample (statistics), 050601 international relations, Gross domestic product, 0506 political science, Bandwagoning, Incentive, Power diffusion, Political Science and International Relations, 050602 political science & public administration, Process capability index, Strategic hedging, Second-tier states, Business, Composite index
Abstract: Background Strategic hedging is a form of behavior used by states wanting to improve their competitiveness while at the same time avoiding direct confrontation with main contenders. It is an appealing option for states facing uncertainty due to structural changes in the international system such as the present unipolarity giving way to a process of power diffusion. Under such conditions, strategic hedging becomes an attractive alternative for other strategies like balancing, bandwagoning, and buckpassing. Especially for second-tier states, it becomes a behavior of choice vis-à-vis the system leader. Aims The strategic hedging research program, however, is in its early stages. Previous research on strategic hedging developed without a clear account of national hedging capabilities, making it difficult to understand key reasons for successful hedging in some cases and its failure in others. This study represents the first attempt to measure the core components of a state’s strategic hedging capability and assuch provides a comparative snapshot of those components by means of a composite index. Methods The index comprises three core dimensions (economic capability, military power and decision-making capability), which are broken down into six sub-indicators: gross domestic product (GDP), foreign exchange and gold reserves, government debt, military expenditure, growth of military arsenal, and democracy. Because second-tier states in the international system are likely to have the greatest incentives to engage in strategic hedging, the composite index developed in this study is applied to a sample of seven leading second-tier states in a comparative case study. Results The results indicate that for states to score high on strategic hedging capability, they need to score high on all core dimensions. Negligence of one of the components leads to a significant decline in total hedging capacity. Such results show why China tops the strategic hedging capability index and scores significantly higher than the other second-tier states.
Published: 2016

31. The role of crystal diversity in understanding mass transfer in nanoporous materials

Author: Isabelle Vandendael, Gino Baron, Joeri Denayer, Christian Chmelik, Julien Cousin Saint Remi, Alexander Lauerer, Herman Terryn, Jörg Kärger, Chemical Engineering and Industrial Chemistry, Faculty of Engineering, Materials and Chemistry, Electrochemical and Surface Engineering, Materials and Surface Science & Engineering, Vriendenkring VUB, Centre for Molecular Separation Science & Technology, Department of Bio-engineering Sciences, Microreactortechnology, and Chemical Engineering and Separation Science
Subjects: Materials science, Nanoporous, Mechanical Engineering, Nanotechnology, 02 engineering and technology, General Chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Environmentally friendly, 0104 chemical sciences, Crystal, Mechanics of Materials, Chemical physics, Mass transfer, Molecule, General Materials Science, 0210 nano-technology, Porous medium, Zeolite, Sheet resistance
Abstract: Nanoporous materials find widespread applications in our society: from drug delivery to environmentally friendly catalysis and separation technologies. The efficient design of these processes depends crucially on understanding the mass transfer mechanism. This is conventionally determined by uptake or release experiments, carried out with assemblages of nanoporous crystals, assuming all crystals to be identical. Using micro-imaging techniques, we now show that even apparently identical crystals (that is, crystals of similar size and shape) from the same batch may exhibit very different uptake rates. The relative contribution of the surface resistance to the overall transport resistance varied with both the crystal and the guest molecule. As a consequence of this crystal diversity, the conventional approach may not distinguish correctly between the different mass transfer mechanisms. Detection of this diversity adds an important new piece of evidence in the search for the origin of the surface barrier phenomenon. Our investigations were carried out with the zeolite SAPO-34, a key material in the methanol-to-olefins (MTO) process, propane-propene separation and adsorptive heat transformation.
Published: 2015

32. Search for resonances in the mass spectrum of muon pairs produced in association with b quark jets in proton-proton collisions at $$ \sqrt{s}=8 $$ and 13 TeV

Author: Etiennette Auffray, Maurizio Biasini, A. Yagil, Sinan Sagir, Marta Felcini, Nikitas Loukas, Mani Tripathi, Rachel Bartek, Marco Peruzzi, Usama Hussain, Owen Rosser Long, Warren Clarida, Dana Z. Anderson, A. Popov, Cesare Calabria, M. Csanad, Nicola Amapane, Matteo Sani, Andreas Nowack, Andrew Ackert, Koushik Mandal, Anton Babaev, Alberto Benvenuti, Matti J Kortelainen, Maria Agnese Ciocci, Maria Florencia Canelli, Cheng-Chieh Peng, Fabrizio Ferro, Thomas Ferbel, Marta Ruspa, Stepan Obraztsov, Anshul Kapoor, C. Neu, Thong Nguyen, David Overton, Sang Il Pak, Roberto Sacchi, Tejinder Virdee, Nicolò Tosi, M. Jones, Camilla Galloni, Seth Conrad Zenz, Andrew Godshalk, Anton Godizov, Vincenzo Daponte, M. Vidal Marono, Daniele Marconi, Julia Thom, Finn Rebassoo, Volker Blobel, Philipp Pigard, Joshua Hardenbrook, Neeti Parashar, W. T. Hung, Klaus Rabbertz, Sebastiano Albergo, Igor Lokhtin, Myriam Schönenberger, Zachary Lesko, Gabriella Pugliese, I. Van Parijs, Andreas Psallidas, C. Vander Velde, Kevin Lannon, G. Della Ricca, Alexandre Zabi, S. M. A. Ghiasi Shirazi, Metin Yalvac, Stephan Lammel, Hugo Delannoy, R. Bhattacharya, Guenakh Mitselmakher, S. Orfanelli, Gobinda Majumder, Jordan Damgov, D. Di Croce, Peter Hansen, E. Carrera Jarrin, Douglas Wright, Kisung Lee, Basile Vermassen, Robert Hirosky, Jay Mathew Lawhorn, Brent Yates, Laurent Favart, Cristian Pena, Thomas Reis, Martin Lipinski, Viatcheslav Stolin, Frank Würthwein, Manas Maity, Alexi Mestvirishvili, Ulrich Goerlach, Joze Zobec, Massimo Casarsa, Steve Nahn, Marco Meschini, Paolo Capiluppi, James Rohlf, Carlos Avila, Sergei Bitioukov, Sergei Baidali, Dooyeon Gyun, Jane Nachtman, R. Gonzalez Suarez, Sergio F Novaes, Samet Lezki, Morgan Lethuillier, Igor Miagkov, Ricardo Eusebi, Daniele Bonacorsi, M. Bharti, V. Sola, Giles Strong, P. Van Hove, Alice Cocoros, Daniel Noonan, Panagiotis Katsoulis, C. Barth, Andrius Juodagalvis, Atanu Modak, M. H.L.S. Wang, G. P. Van Onsem, R. Loveless, Alessio Magitteri, Yasar Onel, Byung-Sik Hong, Stephen Mrenna, Denys Lontkovskyi, Amedeo Staiano, Marco Verzocchi, Fanbo Meng, Caroline Collard, B. McMaster, Fan Xia, Dietrich Liko, Mykhailo Dalchenko, Zaixing Mao, Andrea Gozzelino, Shawn Zaleski, Stephane Perries, Carsten Heidemann, Costas Foudas, Andreas Hinzmann, Michael Hildreth, M. S. Meyer, N. Zaganidis, Alexis Pompili, Julie Malcles, Fengwangdong Zhang, Boris Grynyov, Shengquan Tuo, Abhigyan Dasgupta, Zviad Tsamalaidze, Nikolai Skatchkov, Louis Antonelli, O. Gonzalez Lopez, Olivér Surányi, Sourav Chatterjee, M. Alhusseini, Marco Cipriani, Peter Elmer, Stephan Albert Wiederkehr, F. M. Stober, Marcella Diemoz, M. Flechl, Mikhail Dubinin, G. Cucciati, Ignacio Redondo, Pedro Gras, Benjamin Stieger, Yurii Maravin, Vladimir Gavrilov, H. Sert, Hongbo Liao, Aleko Khukhunaishvili, Stefano Marcellini, Sonaina Undleeb, Georgios Anagnostou, Melody A. Swartz, Maxwell Chertok, Danek Kotlinski, Simone Gelli, A. Melo, Denis Gelé, Catherine Schiber, Mauro Emanuele Dinardo, Carmen Albajar, Sven Dildick, Nhan Viet Tran, R. Vidal, Paraskevas Gianneios, Devdatta Majumder, Kerstin Borras, Ádám Hunyadi, Wei Li, Cecilia Elena Gerber, Stephen Wimpenny, Henning Flacher, Olena Karacheban, Rishi Patel, Y. D. Oh, Andrea Perrotta, Fuqiang Wang, Sergey Polikarpov, Justin Pilot, Marcin Konecki, Artur Lobanov, Nathaniel Pastika, Kyle Tos, Ioannis Evangelou, Geonhee Oh, C. K. Mackay, R. Bi, R. Di Maria, Marc Weinberg, A. C. Le Bihan, Marco Zanetti, U. Bhawandeep, Mohammad Abrar Wadud, Christof Roland, R. M. Brown, Tanmay Sarkar, Matthew Joyce, David Colling, Giacomo Fedi, Dominique Gigi, Benoit Courbon, Raffaello D'Alessandro, D. Domínguez Damiani, Suat Ozkorucuklu, P. Das, Diego Beghin, Gian Michele Innocenti, I. Babounikau, A. Ranieri, Livia Soffi, R. B. Garg, Maria Elena Pol, Oliver Pooth, Fabrizio Palla, Samila Muthumuni, E. Ayala, Hannes Jung, Jasper Lauwers, Wajid Ali Khan, A. G. Stahl Leiton, Petr Moisenz, David Ja Cockerill, Wolfgang Lange, Erik Gottschalk, Amina Zghiche, Alexander Zhokin, Emily MacDonald, Lisa Borgonovi, Wei Xie, Rainer Wallny, Andrea Delgado, Ricardo Lopez-Fernandez, Hamed Bakhshiansohi, Ahmed Ali Abdelalim, Stephan Linn, Cameron Bravo, A. A. Bin Anuar, Nikolaos Manthos, Christian Laner, Martin Grunewald, Christopher Seez, Martijn Mulders, A. Rose, Jan Steggemann, Maciej Misiura, Hongfang Liu, Gilvan Alves, M. Pelliccioni, Anastasia Karavdina, Andrés Cabrera, Jingyu Luo, Ayman Al-bataineh, Prafulla Kumar Behera, Riccardo Andrea Manzoni, A. Bragagnolo, Marc Stöver, Duncan Leggat, Andrew Gilbert, Song-Ming Wang, Ridhi Chawla, Aliakbar Ebrahimi, Markus Spanring, T. W. Wang, Tobias Pook, J. Piedra Gomez, Federico Preiato, Marguerite Tonjes, Tae Jeong Kim, Michael Murray, Jakob Salfeld-Nebgen, Kunal Kothekar, Kamal Lamichhane, Mary Hadley, Bożena Boimska, Inna Kucher, Ada Solano, Damir Lelas, Dajeong Jeon, Piero Giorgio Verdini, Anna Teresa Meneguzzo, Martino Margoni, Meenakshi Narain, Mikhail Danilov, Pieter David, Olga Evdokimov, Joscha Knolle, Junghwan Goh, Livio Fanò, Mirena Ivova Paneva, Andrei Sobol, Christian Veelken, A. Khan, Gouranga Kole, Davide Cieri, M. I. Asghar, Kerem Cankocak, Oleg Prokofyev, Wolfram Erdmann, David Mark Raymond, Olivier Bondu, E. O. Olaiya, Christophe Delaere, Navid Rad, E. Torassa, Yagya Raj Joshi, Dong-Chul Son, Liliana Teodorescu, Giacomo Sguazzoni, Javier Duarte, K. Wong, Yen-Jie Lee, N. De Filippis, Susan Gascon, Thomas Eichhorn, Alessandro Thea, Yu. Andreev, Markus Klute, A. De Cosa, Hannes Sakulin, Bruno Galinhas, Isabel Pedraza, Gabriella Pasztor, Alexander Toropin, Svenja Schumann, Jose Monroy, Rajat Gupta, J. A. Brochero Cifuentes, Harrison Prosper, Gunther Roland, Mara Senghi Soares, Serguei Ganjour, Wolfgang Funk, Ping Tan, Ivan Amos Cali, A. Carvalho Antunes De Oliveira, Jian Sun, Jay Hauser, A. Vilela Pereira, Doga Gulhan, Louis Lyons, Marta Baselga, Florian Kassel, Michael Brodski, K. El Morabit, Jaana Kristiina Heikkilä, Hugues Lattaud, J. G. Branson, Illia Khvastunov, Georg Steinbrück, Paolo Azzurri, Norbert Neumeister, A. Starodumov, Alex Kamenev, Victor Kim, Artur Kalinowski, Rami Kamalieddin, Stephen Robert Wagner, Silvia Taroni, Lea Caminada, Rong-Shyang Lu, Mauro Donegà, Igor Bayshev, H. Keller, Aaron Bundock, Nazar Bartosik, Emilien Chapon, Vittorio Raoul Tavolaro, Tuure Tuuva, Barbara Clerbaux, Willem Verbeke, Armando Lanaro, Ravi Janjam, Siddharth Narayanan, Young Ho Shin, James Hirschauer, M. P. Rauch, Jean-Baptiste Sauvan, Gigi Rolandi, Joel Goldstein, Philip Baringer, Enrico Robutti, George Stephans, Dominik Nowatschin, Alice Magnani, Tilman Rohe, Simon Regnard, I. O. Atakisi, S. Nandan, A. De Iorio, Pietro Vischia, B. De La Cruz, Jose F Benitez, Samuel Higginbotham, Fionn Ball, Kurtis F Johnson, Daniel Bloch, Anton Karneyeu, Leonard Apanasevich, M. Vander Donckt, Emine Gurpinar, Vivek Sharma, Irene Zoi, Cristina Tuve, Leonid Levchuk, B. Penning, R. G. Kellogg, Francisco Matorras, S. Banerjee, Sourav Dey, P. Priyanka, Daniel Rosenzweig, Luciano Ristori, Milena Misheva, Luigi Calligaris, Kevin Pedro, Stefano Argiro, Mikhail Kirsanov, Elizabeth Kennedy, Margaret Zientek, Unki Yang, Jing Wang, Sara Nabili, R. Cousins, Luca Scodellaro, John A Coughlan, T. R. Fernandez Perez Tomei, Ulascan Sarica, Christos Roskas, Katerina Lipka, Martin Kirakosyan, Jochen Schieck, Marvin Johnson, N. Woods, Maria Cepeda, Jorgen D'Hondt, J. M. Vizan Garcia, Christopher Brainerd, Greg P Heath, R. Granier de Cassagnac, Alexey Kalinin, M. Bluj, J. Puerta Pelayo, Indara Suarez, Davide Piccolo, Elizabeth Sexton-Kennedy, T. Mitchell, Bahareh Roozbahani, E. Palencia Cortezon, Hao Qiu, Alexander Dierlamm, Nadeesha Wickramage, Guido Tonelli, Sabino Meola, Roberto Covarelli, Sergio Cittolin, Jared Sturdy, Giuseppe Benedetto Cerati, Stavros Mallios, Johannes Wittmann, James D. Olsen, Matthias Wolf, N. V. Krasnikov, Aobo Zhang, M. G. Albrow, Paolo Ronchese, Borislav Pavlov, Vladimir Karjavine, Csaba Hajdu, Marco Alexander Harrendorf, Ozgun Kara, Daniel Gastler, Zhenbin Wu, Kirika Uchida, Bhawna Gomber, Anna Zanetti, Q. Ingram, P. Van Mechelen, Paul Avery, Salavat Abdullin, Lisa Benato, Quentin Python, Maxime Gouzevitch, Daniele Pedrini, Randy Ruchti, Joe Incandela, Andrea Beschi, Luca Cadamuro, Virginia Azzolini, Nicholas Mucia, Zeljko Antunovic, Christoph Paus, Piergiulio Lenzi, Benedikt Maier, Dmitry Philippov, Fábio Lúcio Alves, Darien Wood, Jyothsna Rani Komaragiri, Silvano Tosi, Ryan Heller, Emyr Clement, Marcello Mannelli, Jia Li, Konrad Deiters, C. Fallon, Alain Givernaud, Andrew Beretvas, Otto Hindrichs, S. Mitra, Aashaq Shah, Lukas Bäni, Seth Moortgat, Badder Marzocchi, Sanjay Kumar Swain, Marc M Baarmand, Michal Szleper, Kaya Tatar, A. Bornheim, Peisen Ma, Roberto Chierici, Chia-Ming Kuo, Sandra S. Padula, Yiwen Wen, Paolo Vitulo, Maximilian Knut Kiesel, Hui Li, Marek Niedziela, R. Wilkinson, Salvatore My, Efe Yazgan, Frank Hartmann, Luciano Orsini, Luca Pacher, J. S. Lange, Mario Maggi, Emanuela Barberis, Mario Masciovecchio, Huilin Qu, T. Tabarelli de Fatis, Christian Schwanenberger, Francesco Brivio, Marco Musich, Dominick Olivito, S. Roy Chowdhury, Colin Jessop, Manfred Paulini, Andrew Hart, Demetrios Loukas, Erik Butz, Jan Kieseler, G. B. Mohanty, Shirin Chenarani, C. A. Carrillo Montoya, Claudia Pistone, Pierluigi Bortignon, T. A. Gómez Espinosa, Ugo Gasparini, Veikko Karimäki, Laura Dodd, Andrew Levin, P. Major, Nadia Pastrone, P. Sphicas, Anindya Roy, Jozsef Molnar, Charalambos Nicolaou, Muhammad Waqas, James Dolen, Michael Dittmar, Claire Shepherd-Themistocleous, Antonis Agapitos, F. Vazquez Valencia, Clément Leloup, R. Kunnawalkam Elayavalli, Steven Kaplan, Thi Hien Doan, Izaak Neutelings, Christoph Schäfer, Daniele Trocino, Maxime Guilbaud, Daniel Treille, Kelvin Mei, S. R. Dugad, Giulia Negro, D. De Jesus Damiao, Giuseppe Fasanella, Sung Keun Park, Y. Ban, M. I. Nagy, James Letts, William J Spalding, Jay Roberts, Stefano Bianco, Lieselotte Moreels, Wolfgang Adam, Allison Reinsvold, Vasken Hagopian, G. M. Dallavalle, Joona Havukainen, Pushpalatha C Bhat, Candan Dozen, M. Calderon De La Barca Sanchez, Freya Blekman, C. Diez Pardos, Michael Wayne Arenton, Niki Saoulidou, Sercan Sen, D. P. Stickland, Giuseppe Zito, Ilse Krätschmer, Zoltan Gecse, Y. H. Chang, Ajeeta Khatiwada, Daniel Denegri, Maciej Górski, David Michael Morse, G. Hamel de Monchenault, Aditee Rane, Predrag Milenovic, Peter R Hobson, Kin Ho Lo, Alexander Grohsjean, Dimitrios Tsitsonis, Peter Thomassen, Anton Stepennov, M. C. Duran-Osuna, Nicholas John Hadley, Jehad Mousa, Karl Matthew Ecklund, Bhargav Madhusudan Joshi, Zeynep Demiragli, Marina Kolosova, Yalcin Guler, Alessandro Braghieri, Johannes Schulz, Bugra Bilin, Kati Lassila-Perini, Petra Merkel, Alexander Nikitenko, Vipin Bhatnagar, T. Liu, Jasvinder A. Singh, M. Rahmani, Min-Hye Kim, Sijing Zhang, Matthieu Marionneau, Mehmet Zeyrek, Roger Wolf, Aleksandar Aleksandrov, Jacob Linacre, Ece Aşılar, Gregory Rakness, Yongbin Feng, Bernard Ille, Sean Kalafut, Ali Mohammadi, J. S. H. Lee, Ettore Focardi, Vallary Bhopatkar, John Rander, Shalini Thakur, Zhenyu Chen, Maria Toms, John Michael Marraffino, E. De La Cruz-Burelo, J. De Clercq, Hartmut Stadie, Natascha Krammer, James Zabel, E. Eskandari Tadavani, Phillip Russell Dudero, Matthias Kasemann, C. 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Quast, Mauro Menichelli, Tamás Álmos Vámi, A. Da Rold, Luca Perniè, Roland Horisberger, Hannsjoerg Artur Weber, Georgios Mavromanolakis, Michele Arneodo, Juan Garcia-Ferrero, Alexei Raspereza, Abhisek Datta, German Martinez, T. Susa, Giannis Flouris, Cristina Botta, O. Hlushchenko, Francesco Fienga, M. Guchait, Renato Potenza, S. Afanasiev, Janos Erö, Francesca Nessi-Tedaldi, R. Del Burgo, Vladimir Mossolov, M. M. Defranchis, Santiago Folgueras, X. Y. Gao, Roman Kogler, Satoshi Hasegawa, Benjamin Kreis, A. Bodek, Oleksii Toldaiev, Mark Pesaresi, Claudia Ciocca, Rachael Bucci, Elisa Manoni, David J. Smith, Gordon H. Hanson, S. Luo, Brieuc Francois, Thomas Madlener, G. F. Chen, Christopher Rogan, Tariq Aziz, Mykola Savitskyi, Dave M Newbold, Andrei Gritsan, K. Hurtado Anampa, Tiziano Rovelli, Cristina Riccardi, Daniele Vadruccio, Francois Lagarde, Georg Sieber, Viesturs Veckalns, Florian Beaudette, Julia Velkovska, Andreas Werner Jung, A. Álvarez Fernández, Narumon Suwonjandee, John Perry Cumalat, Swagata Mukherjee, Kun Shi, Roy Montalvo, R. Sharma, S. Shmatov, F. Torres Da Silva De Araujo, Giuseppe Barbagli, Salvatore Nuzzo, Philippe Bloch, C. De Oliveira Martins, Victor Golovtsov, Martina Vit, Sh. Jain, Grant Riley, Robert Fischer, A. Pérez-Calero Yzquierdo, Guenter Eckerlin, Ravindra Kumar Verma, E. Belchior Batista Das Chagas, Filippo Errico, Deepak Kumar Sahoo, Armen Tumasyan, Iasonas Topsis-Giotis, Marko Dragicevic, Virgil E Barnes, Sudha Ahuja, Chandiprasad Kar, Halil Saka, Pietro Govoni, Raffaele Gerosa, Alexander Ledovskoy, Vincent J Smith, Maryam Zeinali, Patrick Jarry, Jean-Louis Faure, Philipp Millet, Benjamin Charles Radburn-Smith, Philip H Butler, Andrey Marinov, Daniel Arcaro, Marek Walczak, Rishika Bhardwaj, Toni Sculac, Lorenzo Bianchini, Valeria Botta, M. De Palma, V. Monaco, F. Vazzoler, A. Romero, Alessio Ghezzi, Francesca Cenna, A. García Alonso, Alberto Ruiz-Jimeno, Anadi Canepa, Vineet Kumar, Gregor Mittag, Andrea Gelmi, Kenichi Hatakeyama, Anna Woodard, Petr Levchenko, Jennifer Chu, J. H. Kim, János Karancsi, Nicolas Chanon, Helena Malbouisson, Alex J. Barker, S. Lo Meo, Camelia Mironov, George Karathanasis, Shalhout Shalhout, Y. Choi, Gabriel Ramirez-Sanchez, Kevin Nash, Gourab Saha, Valentina Dutta, Dario Bisello, Pascal Paganini, Christopher Mcginn, Thomas Esch, Anne Dabrowski, R. Teixeira De Lima, Paula Eerola, Manoj Sharan, Rakesh Kumar, Bora Akgun, Mariana Araujo, Sarmad Masood Shaheen, Maksym Titov, Daniel Klein, Herbert Rohringer, Federico Ferri, Benedikt Freund, Douglas Berry, Igor Azhgirey, Salvatore Buontempo, Frank Golf, Brandon Allen, Jian-Guo Bian, Andrey Pozdnyakov, R. D. Field, L. Viliani, Inkyu Park, H. Wei, M. Ramirez-Garcia, Troy Mulholland, Dario Menasce, Johannes Haller, James Castle, Nikolai Golubev, R. Walsh, Seungkyu Ha, S. Y. Hoh, Jonas Rembser, F. L. Fabbri, Daniele Fasanella, Viktor Khristenko, Gaël Perrin, Benedikt Vormwald, Ilknur Hos, D. Sunar Cerci, Oliver Gutsche, B. Tali, Luigi Guiducci, Dustin Burns, Umesh Joshi, T. Y. Ling, Tulika Bose, L. J. Sanchez Rosas, Wuming Luo, Giuliana Galati, Z. Wang, Candan Isik, Zukhaimira Zolkapli, D. R. Claes, Marcel Rieger, Anders Ryd, Gavin Davies, Vladimir Popov, Otman Charaf, Daniel Robert Marlow, Thea Klaeboe Aarrestad, Haiyan Wang, Quan Wang, S. Baur, Yves Sirois, Simranjit Singh Chhibra, Christian Schomakers, Vadim Oreshkin, Andrew Carnes, Jordan Tucker, D. Green, Claudio Caputo, Stefano Colafranceschi, C. Scharf, Gregory R Snow, Hualin Mei, Urs Langenegger, Martino Dall'Osso, Hallie Trauger, Brian Francis, Paolo Checchia, Alberto Messineo, John Almond, P. Rebello Teles, Amandeep Kaur Kalsi, Leonard Spiegel, Nikkie Deelen, Radia Redjimi, E. M. Da Costa, Francesco Romeo, Sergey Vavilov, M. Voutilainen, Mehmet Oglakci, Li Li, Robert Klanner, J. N. Butler, Genius Walia, Paolo Lariccia, Dmitry Sosnov, Francesca Cavallari, Alexis Fagot, Achim Geiser, Igor Volobouev, C. E. Flores, Adrian Byszuk, Paolo Giacomelli, Siarhei Shulha, Paolo Gunnellini, Sema Zahid, Andrea Benaglia, Batool Safarzadeh, Andreas Pfeiffer, Darin Acosta, Prakash Thapa, A. Rinkevicius, Jacopo Pazzini, Kreso Kadija, Giovanni Abbiendi, Olivier Davignon, Dmitri Konstantinov, Sarah Freed, Alicia Calderon, S. Bheesette, Xuejun Wang, Jim Hanlon, D. Soldi, Youngkwon Jo, Kristian Allan Hahn, Sergei Gleyzer, Ana Ovcharova, Juliet Ritchie Patterson, Francisco Yumiceva, Ritva Kinnunen, Rui Xiao, Evangelos Paradas, Seyed Mohsen Etesami, Kevin Burkett, Ibrahim Soner Zorbakir, Chad Freer, Stefan Piperov, Crisostomo Sciacca, Maxim Goncharov, K. Ehataht, Eric Conte, Marco Pieri, David Barney, Aleksandra Lelek, Stephanie Beauceron, Joshua Kunkle, Ulrich Husemann, Jeremy Mans, Joao Varela, Fabio Ravera, Maren Tabea Meinhard, Alexander Morton, Javier Cuevas, Claus Kleinwort, J. Lykken, Pasquale Musella, Yangyang Cheng, Peter Robmann, Alexander Lanev, Sandra Oliveros, Alfredo Gurrola, Ufuk Guney Tok, Hyunyong Kim, Petar Maksimovic, Patrick Janot, Andrea Venturi, M. Khakzad, Rino Castaldi, Thorsten Chwalek, Christopher Brew, John Strologas, Andris Skuja, Sébastien Brochet, Ivica Puljak, Hans Reithler, Fabio Monti, Marcello Abbrescia, David Fehling, Ian R Tomalin, Jose Chinellato, Richard Cavanaugh, T. Kress, Susan Dittmer, Kalyanmoy Chatterjee, Georgios Daskalakis, Mythra Varun Nemallapudi, Kirill Skovpen, J. Martin Blanco, Lothar At Bauerdick, Matthew Carver, Leander Litov, Didar Dobur, S. Goy Lopez, Nicole Ruckstuhl, Austin Ball, S. M. Spanier, James S. Wright, Jean-Pierre Merlo, Leonardo Giannini, I. D. Sandoval Gonzalez, Zainol Abidin Ibrahim, Vladimir Blinov, Nathaniel Odell, V. Bunichev, Anton Taurok, D. E. Pellett, J. Fernandez Menendez, Charles Maguire, J. R. González Fernández, Andrea Bocci, Pirmin Berger, Tommaso Dorigo, Konstantinos Theofilatos, David Vannerom, Sandor Czellar, Ben Bylsma, Sanjay Kumar, Ali Celik, Nikola Godinovic, Altan Cakir, S. Fonseca De Souza, Paolo Meridiani, Aron Soha, David Saltzberg, Brian Dorney, Tiziano Camporesi, Andres Tiko, Mariarosaria D'Alfonso, Mario Galanti, Ivan Pozdnyakov, Ruchi Chudasama, Seema Sharma, Sergei Gninenko, Asif Saddique, J. C. Freeman, Petr Mandrik, M. Shi, Nicolas Filipovic, Weinan Si, Geng-Yuan Jeng, Robert M Harris, Sandra Malvezzi, W. L. Prado Da Silva, Pietro Faccioli, Roberto Tenchini, Meng Xiao, Danila Tlisov, Simon Kurz, A. Bat, Vladimir Palichik, Simone Pigazzini, S. Slabospitskii, Shi Zhaozhong, James Keaveney, Marco Rovere, Senka Duric, Matthias Schröder, P. Kontaxakis, Manuel Giffels, Ketino Kaadze, Guler Karapinar, S. Petrushanko, G. Correia Silva, Elliot Hughes, Irene Bachiller, Baokai Wang, Marco Toliman Lucchini, Pavel Bunin, Joanne Cole, Andrew Buccilli, Charles C. 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Haytmyradov, M., Khristenko, V., Merlo, J.-P., Mestvirishvili, A., Moeller, A., Nachtman, J., Ogul, H., Onel, Y., Ozok, F., Penzo, A., Snyder, C., Tiras, E., Wetzel, J., Blumenfeld, B., Cocoros, A., Eminizer, N., Fehling, D., Feng, L., Gritsan, A.V., Hung, W.T., Maksimovic, P., Roskes, J., Sarica, U., Swartz, M., Xiao, M., You, C., Al-bataineh, A., Baringer, P., Bean, A., Boren, S., Bowen, J., Bylinkin, A., Castle, J., Khalil, S., Kropivnitskaya, A., Majumder, D., Mcbrayer, W., Murray, M., Rogan, C., Sanders, S., Schmitz, E., Tapia Takaki, J.D., Duric, S., Ivanov, A., Kaadze, K., Kim, D., Maravin, Y., Mendis, D.R., Mitchell, T., Modak, A., Mohammadi, A., Saini, L.K., Skhirtladze, N., Rebassoo, F., Wright, D., Baden, A., Baron, O., Belloni, A., Eno, S.C., Feng, Y., Ferraioli, C., Hadley, N.J., Jabeen, S., Jeng, G.Y., Kellogg, R.G., Kunkle, J., Mignerey, A.C., Nabili, S., Ricci-Tam, F., Shin, Y.H., Skuja, A., Tonwar, S.C., Wong, K., Abercrombie, D., Allen, B., Azzolini, V., Baty, A., 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Istanbul Bilgi Univ, Hacettepe Univ, Univ Southampton, Monash Univ, Bethel Univ, Karamanoglu Mehmetbey Univ, Utah Valley Univ, Beykent Univ, Bingol Univ, Sinop Univ, Mimar Sinan Univ, Texas A&M Univ Qatar, DA ROLD, A., DELLA RICCA, G., ET AL (the CMS, Collaboration), Karapınar, Güler, Izmir Institute of Technology. Mathematics, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Elementary Particle Physics, Physics, Faculty of Sciences and Bioengineering Sciences, and Vriendenkring VUB
Subjects: transverse momentum: missing-energy, Beyond Standard Model, Hadron-Hadron scattering (experiments), Higgs physics, Nuclear and High Energy Physics, Proton, 13000 GeV-cms, Physics::Instrumentation and Detectors, Physics beyond the Standard Model, measured [channel cross section], Hadron, bottom: particle identification, Jet (particle physics), channel cross section: upper limit, 7. Clean energy, 01 natural sciences, Physics, Particles & Fields, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), scattering [p p], [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Nuclear Experiment, 8000 GeV-cms, Physics, (muon+ muon-) [mass spectrum], 02 Physical Sciences, Large Hadron Collider, upper limit [channel cross section], CMS, Settore FIS/01 - Fisica Sperimentale, central region, dimuon: mass spectrum, bottom [jet], Nuclear & Particles Physics, S015CS, muon: pair production, CERN LHC Coll, Hadron-Hadron Scattering (Experiments), category, Physical Sciences, Physique des particules élémentaires, Higgs boson, PARTICLE PHYSICS, Higgs, physics, particle identification [bottom], mass spectrum [dimuon], colliding beams [p p], narrow resonance, jet: bottom, channel cross section: measured, Particle Physics - Experiment, p p: scattering, Particle physics, Higgs Physics, production [resonance], Astrophysics::High Energy Astrophysical Phenomena, 8000 GeV-cms13000 GeV-cms, jet: associated production, MSSM HIGGS BOSONS, FOS: Physical sciences, 114 Physical sciences, Bottom quark, PP COLLISIONS, 0103 physical sciences, ddc:530, associated production [jet], pair production [muon], S056ZOT, 010306 general physics, 01 Mathematical Sciences, mass spectrum [muon], Science & Technology, Muon, mass [dimuon], LARGE HADRON COLLIDER, hep-ex, background, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Higgs physic, high energy physics, experimental particle physics, LHC, standard model, pair [muon], mass spectrum: (muon+ muon-), missing-energy [transverse momentum], Beyond Standard Model, Hadron-Hadron scattering (experiments), Higgs physics, High Energy Physics::Experiment, p p: colliding beams, CMS collaboration, proton-proton collisions, BSM, experimental results, resonance: production
Abstract: A search for resonances in the mass range 12–70 GeV produced in association with a b quark jet and a second jet, and decaying to a muon pair, is reported. The analysis is based on data from proton-proton collisions at center-of-mass energies of 8 and 13 TeV, collected with the CMS detector at the LHC and corresponding to integrated luminosities of 19.7 and 35.9 fb−1, respectively. The search is carried out in two mutually exclusive event categories. Events in the first category are required to have a b quark jet in the central region (, 0, info:eu-repo/semantics/published
Published: 2018
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33. Neutrophils enhance early Trypanosoma brucei infection onset

Author: Marie Malissen, Guy Caljon, Carl De Trez, Fabienne Tacchini-Cottier, Stefan Magez, Jo A. Van Ginderachter, Dorien Mabille, Benoit Stijlemans, Patrick De Baetselier, Massimiliano Mazzone, Jan Van Den Abbeele, Cellular and Molecular Immunology (VIB), Vrije Universiteit Brussel (VUB), Laboratory of Myeloid Cell Immunology, Flanders Interuniversity Institute for Biotechnology (VIB), Vlaams Interuniversitair Instituut voor Biotechnologie, Department of Biochemistry, Université de Lausanne (UNIL)-WHO Collaborating Center for Research and Training in Immunology, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Structural Biology Research Center, VIB, 1050 Brussels, Belgium, VIB-VUB Center for Structural Biology [Bruxelles], VIB [Belgium]-VIB [Belgium], Vrije Universiteit Brussel - Myeloid Cell immunology Laboratory, Laboratory of cellular & Molecular Immunology [Vrije Universiteit Brussel], Cellular and Molecular Immunology, Department of Bio-engineering Sciences, Vriendenkring VUB, Université de Lausanne = University of Lausanne (UNIL)-WHO Collaborating Center for Research and Training in Immunology, and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0301 basic medicine, Chemokine CXCL5, Chemokine, GLOSSINA-MORSITANS, HOST, Neutrophils, Chemokine CXCL1, Interleukin-1beta, CATTLE, lcsh:Medicine, Parasitemia, Mice, Medicine and Health Sciences, SAND FLIES, lcsh:Science, AFRICAN TRYPANOSOMES, CONGOLENSE, Multidisciplinary, biology, FLIES, Dermis, Interleukin-10, 3. Good health, Multidisciplinary Sciences, CXCL1, Science & Technology - Other Topics, [SDV.IMM]Life Sciences [q-bio]/Immunology, Engineering sciences. Technology, Tsetse Flies, Trypanosoma brucei brucei, TSETSE-FLY, Trypanosoma brucei, Neutropenia, DENDRITIC CELLS, Article, Microbiology, Proinflammatory cytokine, 03 medical and health sciences, Animals, Gene Expression Regulation, Insect Bites and Stings, Insect Vectors, Interleukin-6, Luminescent Measurements, Trypanosomiasis, African, Trypanosomiasis, parasitic diseases, medicine, LOCAL SKIN REACTIONS, Biology, Science & Technology, lcsh:R, African, Biology and Life Sciences, medicine.disease, Leishmania, biology.organism_classification, 030104 developmental biology, SHEEP, general, biology.protein, lcsh:Q, LEISHMANIASIS
Abstract: In this study, Trypanosoma brucei was naturally transmitted to mice through the bites of infected Glossina morsitans tsetse flies. Neutrophils were recruited rapidly to the bite site, whereas monocytes were attracted more gradually. Expression of inflammatory cytokines (il1b, il6), il10 and neutrophil chemokines (cxcl1, cxcl5) was transiently up-regulated at the site of parasite inoculation. Then, a second influx of neutrophils occurred that coincided with the previously described parasite retention and expansion in the ear dermis. Congenital and experimental neutropenia models, combined with bioluminescent imaging, indicate that neutrophils do not significantly contribute to dermal parasite control and elicit higher systemic parasitemia levels during the infection onset. Engulfment of parasites by neutrophils in the skin was rarely observed and was restricted to parasites with reduced motility/viability, whereas live parasites escaped phagocytosis. To our knowledge, this study represents the first description of a trypanosome infection promoting role of early innate immunological reactions following an infective tsetse fly bite. Our data indicate that the trypanosome is not hindered in its early development and benefits from the host innate responses with the neutrophils being important regulators of the early infection, as already demonstrated for the sand fly transmitted Leishmania parasite.
Published: 2018

34. Assessment of dioxin-like activity in PM10 air samples from an industrial location in Algeria, using the DRE-CALUX bioassay

Author: Noureddine Yassaa, Sidali Khedidji, Riad Ladji, Kim Croes, Marc Elskens, Willy Baeyens, Michael S. Denison, Analytical, Environmental & Geo-Chemistry, Chemistry, Vriendenkring VUB, and Earth System Sciences
Subjects: Pollutant, Pollution, 010504 meteorology & atmospheric sciences, Chemistry, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Polychlorinated dibenzodioxins, Humidity, General Medicine, 010501 environmental sciences, Particulates, dl-PCBs, 01 natural sciences, chemistry.chemical_compound, PM10, CALUX, Environmental chemistry, PCDD/Fs, Environmental Chemistry, Ecotoxicology, Bioassay, 0105 earth and related environmental sciences, media_common
Abstract: When compared to the European guidelines, PM10 (particulate matter up to 10-μm size) concentrations in Algeria are often exceeding the maximum limits, and in general, no information exists on the compounds bound on its surface. The objective of this study was to measure the dioxin-like activity of polychlorinated dibenzodioxines and dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (PCBs) in the PM10 fraction at the Sour El Ghozlane cement plant in Algeria. PM10 samples (n = 23) were taken between 24 March and 15 April 2013, using a medium volume sampler and 47-mm PTFE filters. The 24-h samples were dried to determine the PM10 content and afterward extracted, cleaned up, and analyzed with the dioxin-responsive element–chemical-activated luciferase gene expression (DRE-CALUX) bioassay. Our results showed that the measured bioanalytical equivalents (BEQs) were similar to those in other international industrial sites worldwide. The PCDD/Fs and dioxin-like PCBs (dl-PCBs) were positively correlated (rho = 0.6, p = 0.002), indicating that they have similar sources. Furthermore, samples from March showed higher PCDD/F and dl-PCB BEQs and humidity but lower temperatures compared to samples from April, while there was no difference in the PM10 concentrations between the two months. These results reveal that PM10 alone is not a good proxy and that meteorological conditions are an important factor in assessing dioxin-like pollution in the atmosphere. It seems that, at present, there is no health hazard through direct airborne human exposure to dioxin-like pollutants in PM10 from this site. However, it is important to monitor these POPs for a longer period of time and also to gain more insight in their distribution between the particulate and gas phase in relation to meteorological conditions.
Published: 2015

35. Pancreas and gallbladder agenesis in a newborn with semilobar holoprosencephaly, a case report

Author: Pieter In 'T Veld, Robert Hilbrands, Alex Michotte, Annieta Goossens, Kathelijn Keymolen, Miriam Marichal, Jean De Schepper, Filip Cools, Harry Heimberg, Andrew T. Hattersley, Faculty of Medicine and Pharmacy, Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Clinical sciences, Anatomy, Basic (bio-) Medical Sciences, Neuroprotection & Neuromodulation, Vriendenkring VUB, Medicine and Pharmacy academic/administration, Growth and Development, Pathology, Pediatrics, Biology of the Testis, Beta Cell Neogenesis, and Experimental Pathology
Subjects: 0301 basic medicine, Pathology, Developmental Disabilities, Developmental Disabilities/diagnosis, Case Report, Autopsy, Infant, Newborn, Diseases, Neonatal diabetes mellitus, Holoprosencephaly, Pancreas agenesis, Medicine, Genetics (clinical), Brain, Gallbladder, Semilobar holoprosencephaly, 3. Good health, medicine.anatomical_structure, Brain/abnormalities, Agenesis, Female, Gallbladder/abnormalities, Beta cell, Pancreas, lcsh:Internal medicine, medicine.medical_specialty, lcsh:QH426-470, European Continental Ancestry Group, Pancreas/abnormalities, Holoprosencephaly/diagnosis, White People, Congenital Abnormalities, 03 medical and health sciences, Internal medicine, Genetics, Humans, lcsh:RC31-1245, business.industry, Infant, Newborn, Sequence Analysis, DNA, medicine.disease, Congenital Abnormalities/diagnosis, Infant, Newborn, Diseases/diagnosis, lcsh:Genetics, 030104 developmental biology, Endocrinology, Premanent neonatal diabetes mellitus, business
Abstract: Background Pancreatic agenesis is an extremely rare cause of neonatal diabetes mellitus and has enabled the discovery of several key transcription factors essential for normal pancreas and beta cell development. Case presentation We report a case of a Caucasian female with complete pancreatic agenesis occurring together with semilobar holoprosencephaly (HPE), a more common brain developmental disorder. Clinical findings were later confirmed by autopsy, which also identified agenesis of the gallbladder. Although the sequences of a selected set of genes related to pancreas agenesis or HPE were wild-type, the patient’s phenotype suggests a genetic defect that emerges early in embryonic development of brain, gallbladder and pancreas. Conclusions Developmental defects of the pancreas and brain can occur together. Identifying the genetic defect may identify a novel key regulator in beta cell development.
Published: 2017

36. Questions and Answers on the Belgian Model of Integral End-of-Life Care: Experiment? Prototype?

Author: Arsène Mullie, Michael A. Ashby, Wim Distelmans, Jan L. Bernheim, Pharmacology, Family Medicine and Chronic Care, Vriendenkring VUB, End-of-life Care Research Group, Mental Health and Wellbeing research group, Translational Radiation Oncology and Physics, and Clinical sciences
Subjects: medicine.medical_specialty, Internationality, Health (social science), Palliative care, curriculum, Medical law, secularism, Christianity, decision making, Paternalism, terminal care, Belgium, Nursing, Health care, medicine, Humans, Mental Competency, Interview, Sociology, Wedge Argument, Ethics Consultation, Physician-Patient Relations, Euthanasia, business.industry, Research Support, Non-U.S. Gov't, Health Policy, Palliative Care, Beneficence, physician's role, Bioethics, History, 20th Century, United States, humanities, Europe, Minors, Deep sedation, Education, Medical, Graduate, Historical Article, Family medicine, Personal Autonomy, business, End-of-life care
Abstract: This article analyses domestic and foreign reactions to a 2008 report in the British Medical Journal on the complementary and, as argued, synergistic relationship between palliative care and euthanasia in Belgium. The earliest initiators of palliative care in Belgium in the late 1970s held the view that access to proper palliative care was a precondition for euthanasia to be acceptable and that euthanasia and palliative care could, and should, develop together. Advocates of euthanasia including author Jan Bernheim, independent from but together with British expatriates, were among the founders of what was probably the first palliative care service in Europe outside of the United Kingdom. In what has become known as the Belgian model of integral end-of-life care, euthanasia is an available option, also at the end of a palliative care pathway. This approach became the majority view among the wider Belgian public, palliative care workers, other health professionals, and legislators. The legal regulation of euthanasia in 2002 was preceded and followed by a considerable expansion of palliative care services. It is argued that this synergistic development was made possible by public confidence in the health care system and widespread progressive social attitudes that gave rise to a high level of community support for both palliative care and euthanasia. The Belgian model of so-called integral end-of-life care is continuing to evolve, with constant scrutiny of practice and improvements to procedures. It still exhibits several imperfections, for which some solutions are being developed. This article analyses this model by way of answers to a series of questions posed by Journal of Bioethical Inquiry consulting editor Michael Ashby to the Belgian authors.
Published: 2014

37. 20 Jaar gz-psycholoog, en nu afschaffen die titel…

Author: Jan Derksen, Vriendenkring VUB, and Personality and Psychopathology
Subjects: media_common.quotation_subject, Art, Theology, media_common
Abstract: De gz-psycholoog is een succes, de titel niet. Ik krijgt het ook al twintig jaar niet ‘tussen de oren’ bij mijn collega’s niet-psychologen. Zij blijven doen wat heel Nederland doet, ze noemen ons psychologen en snappen wat een psycholoog is en kan.
Published: 2018

38. Time-Course of Contrast Enhancement in Spleen and Liver with Exia 160, Fenestra LC, and VC

Author: Rudi Deklerck, Christian Vanhove, Axel Bossuyt, Inneke Willekens, Johan De Mey, Tony Lahoutte, Nico Buls, Supporting clinical sciences, Medical Imaging, Translational Imaging Research Alliance, Electronics and Informatics, Multidimensional signal processing and communication, Vriendenkring VUB, Nuclear Medicine, and Body Composition and Morphology
Subjects: Male, Cancer Research, Pathology, medicine.medical_specialty, Time Factors, Contrast enhancement, Metabolic Clearance Rate, Contrast Media, Spleen, Mice, Image Processing, Computer-Assisted, medicine, Animals, Radiology, Nuclear Medicine and imaging, Radionuclide Imaging, High iodine, business.industry, X-Ray Microtomography, Mice, Inbred C57BL, medicine.anatomical_structure, Liver, Nonlinear Dynamics, Oncology, Contrast injection, Time course, business
Abstract: OBJECTIVE: The purpose of this study was to compare the time-course of contrast-enhancement in spleen and liver using Exia 160 in comparison with Fenestra LC and VC in healthy mice. PROCEDURES: Healthy C57bl/6 mice were used in this study. Fenestra LC and VC was administered intravenously at a dose of 0.1 ml/20 g or 0.2 ml/20 g. Exia 160 at a dose of 0.05 ml/20 g or 0.1 ml/20 g. Each animal underwent a micro-CT scan before contrast injection (baseline) and immediately after contrast injection. Additional scans were performed at 1, 2, 3, 4, 24, and 48 h after contrast administration. The mice who received Exia 160 were also scanned after 15, 30, and 45 min. RESULTS: The peak enhancement of Exia 160 occurred after 15 min for the spleen and after 30 min for the liver. CONCLUSIONS: Exia 160 allows rapid spleen and liver enhancement. The high iodine content results in small injection volumes.
Published: 2008

39. PCBs and PCDD/FS in Fish and Fish Products and Their Impact on the Human Body Burden in Belgium

Author: Marc Elskens, Leo Goeyens, Vincent Hanot, Jean-Marie Degroodt, Isabelle Windal, N. Van Larebeke, Willy Baeyens, Martine Leermakers, A. Fontaine, R. De Bont, H. Vanderperren, Chemistry, Vriendenkring VUB, Analytical and Environmental Chemistry, Earth System Sciences, and Analytical, Environmental & Geo-Chemistry
Subjects: Adult, Polychlorinated Dibenzodioxins, Correlation coefficient, Health, Toxicology and Mutagenesis, Gastropoda, Food Contamination, Toxicology, Tetrachlorodibenzodioxin, Animal science, Belgium, Lemon sole, Fish Products, Animals, Humans, CALUX, Ecotoxicology, Benzofurans, Eels, biology, Chemistry, Fishes, risk assessment, Environmental monitoring, General Medicine, Dibenzofurans, Polychlorinated, biology.organism_classification, Fish products, Polychlorinated Biphenyls, Pollution, Whiting, Congener, Adipose Tissue, Environmental chemistry, Sharks, Body Burden, %22">Fish , Water Pollutants, Chemical
Abstract: The concentrations of marker PCBs (28, 52, 101, 118, 138, 153, 180) in fish have been assessed with GC-MS: an average concentration of 540 ng-PCB g(-1) fat (5.02 ng-PCB g(-1) wet weight) was observed. The average concentration of PCDD/Fs, assessed with the CALUX bioassay, amounted to 64 pg-CALUX-TEQ g(-1) fat (0.58 pg-CALUX-TEQ g(-1) wet weight) and that of PCDD/Fs + dioxin-like PCBs amounted to 131 pg-CALUX-TEQ g(-1) fat (1.18 pg-CALUX-TEQ g(-1) wet weight). Results of the PCB congeners analyses show that PCB-153 is the most abundant congener in almost all samples, with also main contributions of the 138- and 180-congeners. For some species such as the sand sole and lemon sole, a fairly constant PCB content, independent of the fat percentage, was observed. For a second group of species such as whelks, cod, and whiting, a positive correlation was observed between their PCB concentration (ng g(-1) fat) and their % of fat. The relationship between marker PCBs and PCDD/Fs concentrations, when plotted on a log scale, fits a straight line (correlation coefficient r = 0.83). With our results on fish and literature data for other food products, intake of marker PCBs and PCDD/Fs could be calculated for the adult population in Belgium (19-60 years old). The Total Daily Intake (TDI) of marker PCBs (ng-PCB day(-1)) ranges between 1690 and 2210. The TDI of PCDD/Fs (pg-CALUX day(-1)) ranges between 80.5 and 122, that of PCDD/Fs + dioxin-like PCBs amounts to 151. When PCDD/Fs in fish are assessed with GC-HRMS, the TDI can be lower. The relative importance of fish regarding marker PCB intake amounts to 15-19%, while regarding PCDD/Fs intake it amounts to 34-51%. Using TDI, the body burden evolution of marker PCBs and PCDD/Fs, with age has been calculated.
Published: 2007

40. Global Progress I: Empirical Evidence for ongoing Increase in Quality-of-life

Author: Francis Heylighen, Jean Bernheim, History, Archeology, Arts, Philosophy and Ethics, Centre Leo Apostel, and Vriendenkring VUB
Subjects: media_common.quotation_subject, Life satisfaction, Pessimism, humanities, Optimism, Quality of life, Happiness, Positive psychology, Psychology, Empirical evidence, Social psychology, Social Sciences (miscellaneous), World view, media_common
Abstract: This paper argues that both the relativist and the pessimist critiques of the idea of progress are inadequate. Progress is defined as increase in global quality of life (QOL). Such QOL is intrinsically subjective, but not relative. It can be reliably measured through "life satisfaction"-type questions. The "World Database of Happiness" provides extensive data on social, economic and psychological factors that correlate with overall QOL. They include wealth, health, security, knowledge, freedom and equality. Various statistical data suggest that all these QOL indicators have undergone significant improvements during the last half century, in most of the world. This gives strong support to the thesis that progress objectively occurs.
Published: 2000

41. Autosomal-dominante kraniometaphysäre Dysplasie

Author: J. Schaper, E. Schönau, B. Schwahn, O. Michel, P. Herkenrath, and Vriendenkring VUB
Subjects: Gynecology, therapy, medicine.medical_specialty, business.industry, Cranio-metaphyseal, medicine.disease, Osteochondrodysplasia, dyplasia, Craniometaphyseal dysplasia, Pediatrics, Perinatology and Child Health, medicine, Macrocephaly, Surgery, craniotubular, business, Children, Dysmorphic facies
Abstract: Die kraniometaphysare Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im fruhen Kleinkindesalter dar, die mit einer deutlichen Sklerose des gesamten Schadels und mit einer Aufweitung der Metaphysen der langen Rohrenknochen einhergeht. Wir berichten uber ein zum Zeitpunkt der Diagnosestellung 18 Monate altes mannliches Kleinkind, das mit zunehmendem Makrozephalus, chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie (Hypertelorismus, breite Nasenwurzel, Zahnirregularitaten) auffallig wurde. Die Mutter des Patienten wies ahnliche Stigmata auf. Durch Rontgenaufnahmen von Schadel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden. Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Uberaktivitat der Osteoblasten hin. Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden. Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig. Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen.
Published: 1996

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