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1. Diffusion imaging genomics provides novel insight into early mechanisms of cerebral small vessel disease

Author

Le Grand, Quentin, primary, Tsuchida, Ami, additional, Koch, Alexandra, additional, Imtiaz, Mohammed-Aslam, additional, Aziz, N. Ahmad, additional, Vigneron, Chloé, additional, Zago, Laure, additional, Lathrop, Mark, additional, Dubrac, Alexandre, additional, Couffinhal, Thierry, additional, Crivello, Fabrice, additional, Matthews, Paul M., additional, Mishra, Aniket, additional, Breteler, Monique M. B., additional, Tzourio, Christophe, additional, and Debette, Stéphanie, additional

Published
2024
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6. Identification of circulating proteins associated with general cognitive function among middle-aged and older adults

Author

Tin, Adrienne, primary, Fohner, Alison E., additional, Yang, Qiong, additional, Brody, Jennifer A., additional, Davies, Gail, additional, Yao, Jie, additional, Liu, Dan, additional, Caro, Ilana, additional, Lindbohm, Joni V., additional, Duggan, Michael R., additional, Meirelles, Osorio, additional, Harris, Sarah E., additional, Gudmundsdottir, Valborg, additional, Taylor, Adele M., additional, Henry, Albert, additional, Beiser, Alexa S., additional, Shojaie, Ali, additional, Coors, Annabell, additional, Fitzpatrick, Annette L., additional, Langenberg, Claudia, additional, Satizabal, Claudia L., additional, Sitlani, Colleen M., additional, Wheeler, Eleanor, additional, Tucker-Drob, Elliot M., additional, Bressler, Jan, additional, Coresh, Josef, additional, Bis, Joshua C., additional, Candia, Julián, additional, Jennings, Lori L., additional, Pietzner, Maik, additional, Lathrop, Mark, additional, Lopez, Oscar L., additional, Redmond, Paul, additional, Gerszten, Robert E., additional, Rich, Stephen S., additional, Heckbert, Susan R., additional, Austin, Thomas R., additional, Hughes, Timothy M., additional, Tanaka, Toshiko, additional, Emilsson, Valur, additional, Vasan, Ramachandran S., additional, Guo, Xiuqing, additional, Zhu, Yineng, additional, Tzourio, Christophe, additional, Rotter, Jerome I., additional, Walker, Keenan A., additional, Ferrucci, Luigi, additional, Kivimäki, Mika, additional, Breteler, Monique M. B., additional, Cox, Simon R., additional, Debette, Stephanie, additional, Mosley, Thomas H., additional, Gudnason, Vilmundur G., additional, Launer, Lenore J., additional, Psaty, Bruce M., additional, Seshadri, Sudha, additional, and Fornage, Myriam, additional

Published
2023
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14. The MRi-Share database: brain imaging in a cross-sectional cohort of 1870 university students

Author

Tsuchida, Ami, primary, Laurent, Alexandre, additional, Crivello, Fabrice, additional, Petit, Laurent, additional, Joliot, Marc, additional, Pepe, Antonietta, additional, Beguedou, Naka, additional, Gueye, Marie-Fateye, additional, Verrecchia, Violaine, additional, Nozais, Victor, additional, Zago, Laure, additional, Mellet, Emmanuel, additional, Debette, Stéphanie, additional, Tzourio, Christophe, additional, and Mazoyer, Bernard, additional

Published
2021
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17. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Author

Malik, Rainer, Chauhan, Ganesh, Anderson, Christopher D, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie L M, Tanislav, Christian, Tatlisumak, Turgut, Chong, Michael, Taylor, Kent D, Thijs, Vincent N S, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Adams, Hieab H H, Wassertheil-Smoller, Sylvia, Wilson, James G, Wiggins, Kerri L, Yang, Qiong, Yusuf, Salim, Consortium, AFGen, Epidemiology, Cohorts for Heart and Aging Research in Genomic, Pressure, International Genomics of Blood, Consortium, INVENT, STARNET, Ago, Tetsuro, Bis, Joshua C, Pastinen, Tomi, Ruusalepp, Arno, Schadt, Eric E, Koplev, Simon, Björkegren, Johan L M, Codoni, Veronica, Civelek, Mete, Smith, Nicholas L, Trégouët, David A, Almgren, Peter, Christophersen, Ingrid E, Roselli, Carolina, Lubitz, Steven A, Ellinor, Patrick T, Tai, E Shyong, Kooner, Jaspal S, Kato, Norihiro, He, Jiang, van der Harst, Pim, Elliott, Paul, Amouyel, Philippe, Chambers, John C, Takeuchi, Fumihiko, Johnson, Andrew D, Group, BioBank Japan Cooperative Hospital, Consortium, COMPASS, Consortium, EPIC-CVD, Consortium, EPIC-InterAct, Consortium, International Stroke Genetics, Consortium, METASTROKE, Consortium, Neurology Working Group of the CHARGE, Ay, Hakan, Network, NINDS Stroke Genetics, Study, UK Young Lacunar DNA, Consortium, MEGASTROKE, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, W. T., Rolfs, Arndt, Bartz, Traci M, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Benavente, Oscar R, Fornage, Myriam, Markus, Hugh S, Howson, Joanna M M, Kamatani, Yoichiro, Debette, Stephanie, Dichgans, Martin, Traylor, Matthew, Sargurupremraj, Muralidharan, Bevan, Steve, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, van der Laan, Sander W, Gretarsdottir, Solveig, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, de Bakker, Paul I W, DeStefano, Anita L, Hoed, Marcel den, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O'Donnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Amin, Najaf, Aparicio, Hugo S, Arnett, Donna K, Attia, John, Beiser, Alexa S, Berr, Claudine, Buring, Julie E, Bustamante, Mariana, Caso, Valeria, Cheng, Yu-Ching, Choi, Seung Hoan, Chowhan, Ayesha, Cullell, Natalia, Dartigues, Jean-François, Delavaran, Hossein, Delgado, Pilar, Dörr, Marcus, Engström, Gunnar, Ford, Ian, Gurpreet, Wander S, Hamsten, Anders, Heitsch, Laura, Hozawa, Atsushi, Ibanez, Laura, Ilinca, Andreea, Ingelsson, Martin, Iwasaki, Motoki, Jackson, Rebecca D, Jood, Katarina, den Hoed, Marcel, Jousilahti, Pekka, Kaffashian, Sara, Kalra, Lalit, Kamouchi, Masahiro, Kitazono, Takanari, Kjartansson, Olafur, Kloss, Manja, Koudstaal, Peter J, Krupinski, Jerzy, Labovitz, Daniel L, Laurie, Cathy C, Levi, Christopher R, Li, Linxin, Lind, Lars, Lindgren, Cecilia M, Lioutas, Vasileios, Liu, Yong Mei, Lopez, Oscar L, Makoto, Hirata, Martinez-Majander, Nicolas, Matsuda, Koichi, Minegishi, Naoko, Montaner, Joan, Morris, Andrew P, Muiño, Elena, Müller-Nurasyid, Martina, Norrving, Bo, Ogishima, Soichi, Parati, Eugenio A, Peddareddygari, Leema Reddy, Pedersen, Nancy L, Pera, Joanna, Perola, Markus, Pezzini, Alessandro, Pileggi, Silvana, Rabionet, Raquel, Riba-Llena, Iolanda, Ribasés, Marta, Romero, Jose R, Roquer, Jaume, Rudd, Anthony G, Sarin, Antti-Pekka, Sarju, Ralhan, Sarnowski, Chloe, Sasaki, Makoto, Satizabal, Claudia L, Satoh, Mamoru, Sattar, Naveed, Sawada, Norie, Sibolt, Gerli, Sigurdsson, Ásgeir, Smith, Albert, Sobue, Kenji, Soriano-Tárraga, Carolina, Stanne, Tara, Stine, O Colin, Stott, David J, Strauch, Konstantin, Takai, Takako, Tanaka, Hideo, Tanno, Kozo, Teumer, Alexander, Tomppo, Liisa, Torres-Aguila, Nuria P, Touze, Emmanuel, Tsugane, Shoichiro, Uitterlinden, Andre G, Valdimarsson, Einar M, van der Lee, Sven J, Völzke, Henry, Wakai, Kenji, Weir, David, Williams, Stephen R, Wolfe, Charles D A, Wong, Quenna, Xu, Huichun, Yamaji, Taiki, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pathology, Epidemiology, Radiology & Nuclear Medicine, Cardiovascular Centre (CVC), Universitat de Barcelona, Traylor, Matthew [0000-0001-6624-8621], Okada, Yukinori [0000-0002-0311-8472], Rutten-Jacobs, Loes [0000-0003-3223-885X], van der Laan, Sander W [0000-0001-6888-1404], Adams, Hieab HH [0000-0003-3687-2508], Almgren, Peter [0000-0002-0473-0241], Amouyel, Philippe [0000-0001-9088-234X], Correa, Adolfo [0000-0002-9501-600X], Cruchaga, Carlos [0000-0002-0276-2899], den Hoed, Marcel [0000-0001-8081-428X], Gustafsson, Stefan [0000-0001-5894-0351], Havulinna, Aki S [0000-0002-4787-8959], Ikram, M Arfan [0000-0003-0372-8585], Jukema, J Wouter [0000-0002-3246-8359], Kanai, Masahiro [0000-0001-5165-4408], Lewis, Cathryn M [0000-0002-8249-8476], Lin, Wei-Yu [0000-0002-9267-7988], Magnusson, Patrik K [0000-0002-7315-7899], Pulit, Sara L [0000-0002-2502-3669], Wiggins, Kerri L [0000-0003-2749-1279], Yang, Qiong [0000-0002-3658-1375], Schadt, Eric E [0000-0002-7892-8808], Koplev, Simon [0000-0002-8586-5614], Civelek, Mete [0000-0002-8141-0284], Trégouët, David A [0000-0001-9084-7800], Christophersen, Ingrid E [0000-0002-6141-4712], Roselli, Carolina [0000-0001-5267-6756], Ellinor, Patrick T [0000-0002-2067-0533], van der Harst, Pim [0000-0002-2713-686X], Elliott, Paul [0000-0002-7511-5684], Takeuchi, Fumihiko [0000-0003-3185-5661], Jern, Christina [0000-0002-7531-2354], Saleheen, Danish [0000-0001-6193-020X], Kamatani, Yoichiro [0000-0001-8748-5597], Dichgans, Martin [0000-0002-0654-387X], and Apollo - University of Cambridge Repository

Subjects
Male, 0301 basic medicine, COMPASS Consortium, Linkage disequilibrium, Candidate gene, UK Young Lacunar DNA Study, Genome-wide association study, SEPIA, Linkage Disequilibrium, Epigenesis, Genetic, classification [Stroke], International Stroke Genetics Consortium (ISGC), 0302 clinical medicine, INDEL Mutation, HEMORRHAGIC STROKE, Risk Factors, Pleiotropy, Databases, Genetic, Neurology Working Group of the CHARGE Consortium, WHITE-MATTER HYPERINTENSITIES, Gene Regulatory Networks, Stroke, Genetics & Heredity, Genetics, International Genomics of Blood Pressure (iGEN-BP) Consortium, physiopathology [Stroke], AFGen Consortium, 11 Medical And Health Sciences, Genomics, 3. Good health, [MEGASTROKE Consortium], ISCHEMIC-STROKE, VINTAGE, genetics [Stroke], CORONARY-ARTERY-DISEASE, Medical genetics, Female, EPIC-InterAct Consortium, MEGASTROKE Consortium, Life Sciences & Biomedicine, Gens, medicine.medical_specialty, SUSCEPTIBILITY LOCI, STARNET, INVENT Consortium, SMALL-VESSEL DISEASE, Biology, Polymorphism, Single Nucleotide, EPIC-CVD Consortium, Article, Chromosomes, HUMAN GENETIC-VARIATION, NINDS Stroke Genetics Network (SiGN), 03 medical and health sciences, ddc:570, Genetic variation, medicine, Humans, Genetic Predisposition to Disease, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Science & Technology, Models, Genetic, COMPLEX TRAITS, Computational Biology, 06 Biological Sciences, medicine.disease, METASTROKE Consortium, Human genetics, Cromosomes, BioBank Japan Cooperative Hospital Group, Genòmica, 030104 developmental biology, Genes, Genetic Loci, ATRIAL-FIBRILLATION, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, SUDDEN CARDIAC DEATH, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study
Abstract

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke sub-types. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.

Published
2018

20. Correction: The genetic history of France

Author

Saint Pierre, Aude, primary, Giemza, Joanna, additional, Alves, Isabel, additional, Karakachoff, Matilde, additional, Gaudin, Marinna, additional, Amouyel, Philippe, additional, Dartigues, Jean-François, additional, Tzourio, Christophe, additional, Monteil, Martial, additional, Galan, Pilar, additional, Hercberg, Serge, additional, Mathieson, Iain, additional, Redon, Richard, additional, Génin, Emmanuelle, additional, and Dina, Christian, additional

Published
2020
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22. The genetic history of France

Author

Saint Pierre, Aude, primary, Giemza, Joanna, additional, Alves, Isabel, additional, Karakachoff, Matilde, additional, Gaudin, Marinna, additional, Amouyel, Philippe, additional, Dartigues, Jean-François, additional, Tzourio, Christophe, additional, Monteil, Martial, additional, Galan, Pilar, additional, Hercberg, Serge, additional, Mathieson, Iain, additional, Redon, Richard, additional, Génin, Emmanuelle, additional, and Dina, Christian, additional

Published
2020
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23. Genetic architecture of subcortical brain structures in 38,851 individuals

Author

Satizabal, Claudia L., primary, Adams, Hieab H. H., additional, Hibar, Derrek P., additional, White, Charles C., additional, Knol, Maria J., additional, Stein, Jason L., additional, Scholz, Markus, additional, Sargurupremraj, Muralidharan, additional, Jahanshad, Neda, additional, Roshchupkin, Gennady V., additional, Smith, Albert V., additional, Bis, Joshua C., additional, Jian, Xueqiu, additional, Luciano, Michelle, additional, Hofer, Edith, additional, Teumer, Alexander, additional, van der Lee, Sven J., additional, Yang, Jingyun, additional, Yanek, Lisa R., additional, Lee, Tom V., additional, Li, Shuo, additional, Hu, Yanhui, additional, Koh, Jia Yu, additional, Eicher, John D., additional, Desrivières, Sylvane, additional, Arias-Vasquez, Alejandro, additional, Chauhan, Ganesh, additional, Athanasiu, Lavinia, additional, Rentería, Miguel E., additional, Kim, Sungeun, additional, Hoehn, David, additional, Armstrong, Nicola J., additional, Chen, Qiang, additional, Holmes, Avram J., additional, den Braber, Anouk, additional, Kloszewska, Iwona, additional, Andersson, Micael, additional, Espeseth, Thomas, additional, Grimm, Oliver, additional, Abramovic, Lucija, additional, Alhusaini, Saud, additional, Milaneschi, Yuri, additional, Papmeyer, Martina, additional, Axelsson, Tomas, additional, Ehrlich, Stefan, additional, Roiz-Santiañez, Roberto, additional, Kraemer, Bernd, additional, Håberg, Asta K., additional, Jones, Hannah J., additional, Pike, G. Bruce, additional, Stein, Dan J., additional, Stevens, Allison, additional, Bralten, Janita, additional, Vernooij, Meike W., additional, Harris, Tamara B., additional, Filippi, Irina, additional, Witte, A. Veronica, additional, Guadalupe, Tulio, additional, Wittfeld, Katharina, additional, Mosley, Thomas H., additional, Becker, James T., additional, Doan, Nhat Trung, additional, Hagenaars, Saskia P., additional, Saba, Yasaman, additional, Cuellar-Partida, Gabriel, additional, Amin, Najaf, additional, Hilal, Saima, additional, Nho, Kwangsik, additional, Mirza-Schreiber, Nazanin, additional, Arfanakis, Konstantinos, additional, Becker, Diane M., additional, Ames, David, additional, Goldman, Aaron L., additional, Lee, Phil H., additional, Boomsma, Dorret I., additional, Lovestone, Simon, additional, Giddaluru, Sudheer, additional, Le Hellard, Stephanie, additional, Mattheisen, Manuel, additional, Bohlken, Marc M., additional, Kasperaviciute, Dalia, additional, Schmaal, Lianne, additional, Lawrie, Stephen M., additional, Agartz, Ingrid, additional, Walton, Esther, additional, Tordesillas-Gutierrez, Diana, additional, Davies, Gareth E., additional, Shin, Jean, additional, Ipser, Jonathan C., additional, Vinke, Louis N., additional, Hoogman, Martine, additional, Jia, Tianye, additional, Burkhardt, Ralph, additional, Klein, Marieke, additional, Crivello, Fabrice, additional, Janowitz, Deborah, additional, Carmichael, Owen, additional, Haukvik, Unn K., additional, Aribisala, Benjamin S., additional, Schmidt, Helena, additional, Strike, Lachlan T., additional, Cheng, Ching-Yu, additional, Risacher, Shannon L., additional, Pütz, Benno, additional, Fleischman, Debra A., additional, Assareh, Amelia A., additional, Mattay, Venkata S., additional, Buckner, Randy L., additional, Mecocci, Patrizia, additional, Dale, Anders M., additional, Cichon, Sven, additional, Boks, Marco P., additional, Matarin, Mar, additional, Penninx, Brenda W. J. H., additional, Calhoun, Vince D., additional, Chakravarty, M. Mallar, additional, Marquand, Andre F., additional, Macare, Christine, additional, Kharabian Masouleh, Shahrzad, additional, Oosterlaan, Jaap, additional, Amouyel, Philippe, additional, Hegenscheid, Katrin, additional, Rotter, Jerome I., additional, Schork, Andrew J., additional, Liewald, David C. M., additional, de Zubicaray, Greig I., additional, Wong, Tien Yin, additional, Shen, Li, additional, Sämann, Philipp G., additional, Brodaty, Henry, additional, Roffman, Joshua L., additional, de Geus, Eco J. C., additional, Tsolaki, Magda, additional, Erk, Susanne, additional, van Eijk, Kristel R., additional, Cavalleri, Gianpiero L., additional, van der Wee, Nic J. A., additional, McIntosh, Andrew M., additional, Gollub, Randy L., additional, Bulayeva, Kazima B., additional, Bernard, Manon, additional, Richards, Jennifer S., additional, Himali, Jayandra J., additional, Loeffler, Markus, additional, Rommelse, Nanda, additional, Hoffmann, Wolfgang, additional, Westlye, Lars T., additional, Valdés Hernández, Maria C., additional, Hansell, Narelle K., additional, van Erp, Theo G. M., additional, Wolf, Christiane, additional, Kwok, John B. J., additional, Vellas, Bruno, additional, Heinz, Andreas, additional, Olde Loohuis, Loes M., additional, Delanty, Norman, additional, Ho, Beng-Choon, additional, Ching, Christopher R. K., additional, Shumskaya, Elena, additional, Singh, Baljeet, additional, Hofman, Albert, additional, van der Meer, Dennis, additional, Homuth, Georg, additional, Psaty, Bruce M., additional, Bastin, Mark E., additional, Montgomery, Grant W., additional, Foroud, Tatiana M., additional, Reppermund, Simone, additional, Hottenga, Jouke-Jan, additional, Simmons, Andrew, additional, Meyer-Lindenberg, Andreas, additional, Cahn, Wiepke, additional, Whelan, Christopher D., additional, van Donkelaar, Marjolein M. J., additional, Yang, Qiong, additional, Hosten, Norbert, additional, Green, Robert C, additional, Thalamuthu, Anbupalam, additional, Mohnke, Sebastian, additional, Hulshoff Pol, Hilleke E., additional, Lin, Honghuang, additional, Jack, Clifford R., additional, Schofield, Peter R., additional, Mühleisen, Thomas W., additional, Maillard, Pauline, additional, Potkin, Steven G., additional, Wen, Wei, additional, Fletcher, Evan, additional, Toga, Arthur W., additional, Gruber, Oliver, additional, Huentelman, Matthew, additional, Davey Smith, George, additional, Launer, Lenore J., additional, Nyberg, Lars, additional, Jönsson, Erik G., additional, Crespo-Facorro, Benedicto, additional, Koen, Nastassja, additional, Greve, Douglas N., additional, Uitterlinden, André G., additional, Weinberger, Daniel R., additional, Steen, Vidar M., additional, Fedko, Iryna O., additional, Groenewold, Nynke A., additional, Niessen, Wiro J., additional, Toro, Roberto, additional, Tzourio, Christophe, additional, Longstreth, William T., additional, Ikram, M. Kamran, additional, Smoller, Jordan W., additional, van Tol, Marie-Jose, additional, Sussmann, Jessika E., additional, Paus, Tomas, additional, Lemaître, Hervé, additional, Schroeter, Matthias L., additional, Mazoyer, Bernard, additional, Andreassen, Ole A., additional, Holsboer, Florian, additional, Depondt, Chantal, additional, Veltman, Dick J., additional, Turner, Jessica A., additional, Pausova, Zdenka, additional, Schumann, Gunter, additional, van Rooij, Daan, additional, Djurovic, Srdjan, additional, Deary, Ian J., additional, McMahon, Katie L., additional, Müller-Myhsok, Bertram, additional, Brouwer, Rachel M., additional, Soininen, Hilkka, additional, Pandolfo, Massimo, additional, Wassink, Thomas H., additional, Cheung, Joshua W., additional, Wolfers, Thomas, additional, Martinot, Jean-Luc, additional, Zwiers, Marcel P., additional, Nauck, Matthias, additional, Melle, Ingrid, additional, Martin, Nicholas G., additional, Kanai, Ryota, additional, Westman, Eric, additional, Kahn, René S., additional, Sisodiya, Sanjay M., additional, White, Tonya, additional, Saremi, Arvin, additional, van Bokhoven, Hans, additional, Brunner, Han G., additional, Völzke, Henry, additional, Wright, Margaret J., additional, van ‘t Ent, Dennis, additional, Nöthen, Markus M., additional, Ophoff, Roel A., additional, Buitelaar, Jan K., additional, Fernández, Guillén, additional, Sachdev, Perminder S., additional, Rietschel, Marcella, additional, van Haren, Neeltje E. M., additional, Fisher, Simon E., additional, Beiser, Alexa S., additional, Francks, Clyde, additional, Saykin, Andrew J., additional, Mather, Karen A., additional, Romanczuk-Seiferth, Nina, additional, Hartman, Catharina A., additional, DeStefano, Anita L., additional, Heslenfeld, Dirk J., additional, Weiner, Michael W., additional, Walter, Henrik, additional, Hoekstra, Pieter J., additional, Nyquist, Paul A., additional, Franke, Barbara, additional, Bennett, David A., additional, Grabe, Hans J., additional, Johnson, Andrew D., additional, Chen, Christopher, additional, van Duijn, Cornelia M., additional, Lopez, Oscar L., additional, Fornage, Myriam, additional, Wardlaw, Joanna M., additional, Schmidt, Reinhold, additional, DeCarli, Charles, additional, De Jager, Philip L., additional, Villringer, Arno, additional, Debette, Stéphanie, additional, Gudnason, Vilmundur, additional, Medland, Sarah E., additional, Shulman, Joshua M., additional, Thompson, Paul M., additional, Seshadri, Sudha, additional, and Ikram, M. Arfan, additional

Published
2019
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25. Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases

Author

Chen, Jason A., primary, Chen, Zhongbo, additional, Won, Hyejung, additional, Huang, Alden Y., additional, Lowe, Jennifer K., additional, Wojta, Kevin, additional, Yokoyama, Jennifer S., additional, Bensimon, Gilbert, additional, Leigh, P. Nigel, additional, Payan, Christine, additional, Shatunov, Aleksey, additional, Jones, Ashley R., additional, Lewis, Cathryn M., additional, Deloukas, Panagiotis, additional, Amouyel, Philippe, additional, Tzourio, Christophe, additional, Dartigues, Jean-Francois, additional, Ludolph, Albert, additional, Boxer, Adam L., additional, Bronstein, Jeff M., additional, Al-Chalabi, Ammar, additional, Geschwind, Daniel H., additional, and Coppola, Giovanni, additional

Published
2018
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28. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

Author

Chibnik, Lori B., primary, Wolters, Frank J., additional, Bäckman, Kristoffer, additional, Beiser, Alexa, additional, Berr, Claudine, additional, Bis, Joshua C., additional, Boerwinkle, Eric, additional, Bos, Daniel, additional, Brayne, Carol, additional, Dartigues, Jean-Francois, additional, Darweesh, Sirwan K. L., additional, Debette, Stephanie, additional, Davis-Plourde, Kendra L., additional, Dufouil, Carole, additional, Fornage, Myriam, additional, Grasset, Leslie, additional, Gudnason, Vilmundur, additional, Hadjichrysanthou, Christoforos, additional, Helmer, Catherine, additional, Ikram, M. Arfan, additional, Ikram, M. Kamran, additional, Kern, Silke, additional, Kuller, Lewis H., additional, Launer, Lenore, additional, Lopez, Oscar L., additional, Matthews, Fiona, additional, Meirelles, Osorio, additional, Mosley, Thomas, additional, Ower, Alison, additional, Psaty, Bruce M., additional, Satizabal, Claudia L., additional, Seshadri, Sudha, additional, Skoog, Ingmar, additional, Stephan, Blossom C. M., additional, Tzourio, Christophe, additional, Waziry, Reem, additional, Wong, Mei Mei, additional, Zettergren, Anna, additional, and Hofman, Albert, additional

Published
2017
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30. Novel genetic loci associated with hippocampal volume

Author

Hibar, Derrek P., primary, Adams, Hieab H. H., additional, Jahanshad, Neda, additional, Chauhan, Ganesh, additional, Stein, Jason L., additional, Hofer, Edith, additional, Renteria, Miguel E., additional, Bis, Joshua C., additional, Arias-Vasquez, Alejandro, additional, Ikram, M. Kamran, additional, Desrivières, Sylvane, additional, Vernooij, Meike W., additional, Abramovic, Lucija, additional, Alhusaini, Saud, additional, Amin, Najaf, additional, Andersson, Micael, additional, Arfanakis, Konstantinos, additional, Aribisala, Benjamin S., additional, Armstrong, Nicola J., additional, Athanasiu, Lavinia, additional, Axelsson, Tomas, additional, Beecham, Ashley H., additional, Beiser, Alexa, additional, Bernard, Manon, additional, Blanton, Susan H., additional, Bohlken, Marc M., additional, Boks, Marco P., additional, Bralten, Janita, additional, Brickman, Adam M., additional, Carmichael, Owen, additional, Chakravarty, M. Mallar, additional, Chen, Qiang, additional, Ching, Christopher R. K., additional, Chouraki, Vincent, additional, Cuellar-Partida, Gabriel, additional, Crivello, Fabrice, additional, Den Braber, Anouk, additional, Doan, Nhat Trung, additional, Ehrlich, Stefan, additional, Giddaluru, Sudheer, additional, Goldman, Aaron L., additional, Gottesman, Rebecca F., additional, Grimm, Oliver, additional, Griswold, Michael E., additional, Guadalupe, Tulio, additional, Gutman, Boris A., additional, Hass, Johanna, additional, Haukvik, Unn K., additional, Hoehn, David, additional, Holmes, Avram J., additional, Hoogman, Martine, additional, Janowitz, Deborah, additional, Jia, Tianye, additional, Jørgensen, Kjetil N., additional, Karbalai, Nazanin, additional, Kasperaviciute, Dalia, additional, Kim, Sungeun, additional, Klein, Marieke, additional, Kraemer, Bernd, additional, Lee, Phil H., additional, Liewald, David C. M., additional, Lopez, Lorna M., additional, Luciano, Michelle, additional, Macare, Christine, additional, Marquand, Andre F., additional, Matarin, Mar, additional, Mather, Karen A., additional, Mattheisen, Manuel, additional, McKay, David R., additional, Milaneschi, Yuri, additional, Muñoz Maniega, Susana, additional, Nho, Kwangsik, additional, Nugent, Allison C., additional, Nyquist, Paul, additional, Loohuis, Loes M. Olde, additional, Oosterlaan, Jaap, additional, Papmeyer, Martina, additional, Pirpamer, Lukas, additional, Pütz, Benno, additional, Ramasamy, Adaikalavan, additional, Richards, Jennifer S., additional, Risacher, Shannon L., additional, Roiz-Santiañez, Roberto, additional, Rommelse, Nanda, additional, Ropele, Stefan, additional, Rose, Emma J., additional, Royle, Natalie A., additional, Rundek, Tatjana, additional, Sämann, Philipp G., additional, Saremi, Arvin, additional, Satizabal, Claudia L., additional, Schmaal, Lianne, additional, Schork, Andrew J., additional, Shen, Li, additional, Shin, Jean, additional, Shumskaya, Elena, additional, Smith, Albert V., additional, Sprooten, Emma, additional, Strike, Lachlan T., additional, Teumer, Alexander, additional, Tordesillas-Gutierrez, Diana, additional, Toro, Roberto, additional, Trabzuni, Daniah, additional, Trompet, Stella, additional, Vaidya, Dhananjay, additional, Van der Grond, Jeroen, additional, Van der Lee, Sven J., additional, Van der Meer, Dennis, additional, Van Donkelaar, Marjolein M. J., additional, Van Eijk, Kristel R., additional, Van Erp, Theo G. M., additional, Van Rooij, Daan, additional, Walton, Esther, additional, Westlye, Lars T., additional, Whelan, Christopher D., additional, Windham, Beverly G., additional, Winkler, Anderson M., additional, Wittfeld, Katharina, additional, Woldehawariat, Girma, additional, Wolf, Christiane, additional, Wolfers, Thomas, additional, Yanek, Lisa R., additional, Yang, Jingyun, additional, Zijdenbos, Alex, additional, Zwiers, Marcel P., additional, Agartz, Ingrid, additional, Almasy, Laura, additional, Ames, David, additional, Amouyel, Philippe, additional, Andreassen, Ole A., additional, Arepalli, Sampath, additional, Assareh, Amelia A., additional, Barral, Sandra, additional, Bastin, Mark E., additional, Becker, Diane M., additional, Becker, James T., additional, Bennett, David A., additional, Blangero, John, additional, van Bokhoven, Hans, additional, Boomsma, Dorret I., additional, Brodaty, Henry, additional, Brouwer, Rachel M., additional, Brunner, Han G., additional, Buckner, Randy L., additional, Buitelaar, Jan K., additional, Bulayeva, Kazima B., additional, Cahn, Wiepke, additional, Calhoun, Vince D., additional, Cannon, Dara M., additional, Cavalleri, Gianpiero L., additional, Cheng, Ching-Yu, additional, Cichon, Sven, additional, Cookson, Mark R., additional, Corvin, Aiden, additional, Crespo-Facorro, Benedicto, additional, Curran, Joanne E., additional, Czisch, Michael, additional, Dale, Anders M., additional, Davies, Gareth E., additional, De Craen, Anton J. M., additional, De Geus, Eco J. C., additional, De Jager, Philip L., additional, De Zubicaray, Greig I., additional, Deary, Ian J., additional, Debette, Stéphanie, additional, DeCarli, Charles, additional, Delanty, Norman, additional, Depondt, Chantal, additional, DeStefano, Anita, additional, Dillman, Allissa, additional, Djurovic, Srdjan, additional, Donohoe, Gary, additional, Drevets, Wayne C., additional, Duggirala, Ravi, additional, Dyer, Thomas D., additional, Enzinger, Christian, additional, Erk, Susanne, additional, Espeseth, Thomas, additional, Fedko, Iryna O., additional, Fernández, Guillén, additional, Ferrucci, Luigi, additional, Fisher, Simon E., additional, Fleischman, Debra A., additional, Ford, Ian, additional, Fornage, Myriam, additional, Foroud, Tatiana M., additional, Fox, Peter T., additional, Francks, Clyde, additional, Fukunaga, Masaki, additional, Gibbs, J. Raphael, additional, Glahn, David C., additional, Gollub, Randy L., additional, Göring, Harald H. H., additional, Green, Robert C., additional, Gruber, Oliver, additional, Gudnason, Vilmundur, additional, Guelfi, Sebastian, additional, Håberg, Asta K., additional, Hansell, Narelle K., additional, Hardy, John, additional, Hartman, Catharina A., additional, Hashimoto, Ryota, additional, Hegenscheid, Katrin, additional, Heinz, Andreas, additional, Le Hellard, Stephanie, additional, Hernandez, Dena G., additional, Heslenfeld, Dirk J., additional, Ho, Beng-Choon, additional, Hoekstra, Pieter J., additional, Hoffmann, Wolfgang, additional, Hofman, Albert, additional, Holsboer, Florian, additional, Homuth, Georg, additional, Hosten, Norbert, additional, Hottenga, Jouke-Jan, additional, Huentelman, Matthew, additional, Hulshoff Pol, Hilleke E., additional, Ikeda, Masashi, additional, Jack Jr, Clifford R., additional, Jenkinson, Mark, additional, Johnson, Robert, additional, Jönsson, Erik G., additional, Jukema, J. Wouter, additional, Kahn, René S., additional, Kanai, Ryota, additional, Kloszewska, Iwona, additional, Knopman, David S., additional, Kochunov, Peter, additional, Kwok, John B., additional, Lawrie, Stephen M., additional, Lemaître, Hervé, additional, Liu, Xinmin, additional, Longo, Dan L., additional, Lopez, Oscar L., additional, Lovestone, Simon, additional, Martinez, Oliver, additional, Martinot, Jean-Luc, additional, Mattay, Venkata S., additional, McDonald, Colm, additional, McIntosh, Andrew M., additional, McMahon, Francis J., additional, McMahon, Katie L., additional, Mecocci, Patrizia, additional, Melle, Ingrid, additional, Meyer-Lindenberg, Andreas, additional, Mohnke, Sebastian, additional, Montgomery, Grant W., additional, Morris, Derek W., additional, Mosley, Thomas H., additional, Mühleisen, Thomas W., additional, Müller-Myhsok, Bertram, additional, Nalls, Michael A., additional, Nauck, Matthias, additional, Nichols, Thomas E., additional, Niessen, Wiro J., additional, Nöthen, Markus M., additional, Nyberg, Lars, additional, Ohi, Kazutaka, additional, Olvera, Rene L., additional, Ophoff, Roel A., additional, Pandolfo, Massimo, additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Penninx, Brenda W. J. H., additional, Pike, G. Bruce, additional, Potkin, Steven G., additional, Psaty, Bruce M., additional, Reppermund, Simone, additional, Rietschel, Marcella, additional, Roffman, Joshua L., additional, Romanczuk-Seiferth, Nina, additional, Rotter, Jerome I., additional, Ryten, Mina, additional, Sacco, Ralph L., additional, Sachdev, Perminder S., additional, Saykin, Andrew J., additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Schofield, Peter R., additional, Sigursson, Sigurdur, additional, Simmons, Andrew, additional, Singleton, Andrew, additional, Sisodiya, Sanjay M., additional, Smith, Colin, additional, Smoller, Jordan W., additional, Soininen, Hilkka, additional, Steen, Vidar M., additional, Stott, David J., additional, Sussmann, Jessika E., additional, Thalamuthu, Anbupalam, additional, Toga, Arthur W., additional, Traynor, Bryan J., additional, Troncoso, Juan, additional, Tsolaki, Magda, additional, Tzourio, Christophe, additional, Uitterlinden, Andre G., additional, Hernández, Maria C. Valdés, additional, Van der Brug, Marcel, additional, van der Lugt, Aad, additional, van der Wee, Nic J. A., additional, Van Haren, Neeltje E. M., additional, van ’t Ent, Dennis, additional, Van Tol, Marie-Jose, additional, Vardarajan, Badri N., additional, Vellas, Bruno, additional, Veltman, Dick J., additional, Völzke, Henry, additional, Walter, Henrik, additional, Wardlaw, Joanna M., additional, Wassink, Thomas H., additional, Weale, Michael E., additional, Weinberger, Daniel R., additional, Weiner, Michael W., additional, Wen, Wei, additional, Westman, Eric, additional, White, Tonya, additional, Wong, Tien Y., additional, Wright, Clinton B., additional, Zielke, Ronald H., additional, Zonderman, Alan B., additional, Martin, Nicholas G., additional, Van Duijn, Cornelia M., additional, Wright, Margaret J., additional, Longstreth, W. T., additional, Schumann, Gunter, additional, Grabe, Hans J., additional, Franke, Barbara, additional, Launer, Lenore J., additional, Medland, Sarah E., additional, Seshadri, Sudha, additional, Thompson, Paul M., additional, and Ikram, M. Arfan, additional

Published
2017
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31. Novel genetic loci underlying human intracranial volume identified through genome-wide association

Author

Adams, Hieab H H, primary, Hibar, Derrek P, additional, Chouraki, Vincent, additional, Stein, Jason L, additional, Nyquist, Paul A, additional, Rentería, Miguel E, additional, Trompet, Stella, additional, Arias-Vasquez, Alejandro, additional, Seshadri, Sudha, additional, Desrivières, Sylvane, additional, Beecham, Ashley H, additional, Jahanshad, Neda, additional, Wittfeld, Katharina, additional, Van der Lee, Sven J, additional, Abramovic, Lucija, additional, Alhusaini, Saud, additional, Amin, Najaf, additional, Andersson, Micael, additional, Arfanakis, Konstantinos, additional, Aribisala, Benjamin S, additional, Armstrong, Nicola J, additional, Athanasiu, Lavinia, additional, Axelsson, Tomas, additional, Beiser, Alexa, additional, Bernard, Manon, additional, Bis, Joshua C, additional, Blanken, Laura M E, additional, Blanton, Susan H, additional, Bohlken, Marc M, additional, Boks, Marco P, additional, Bralten, Janita, additional, Brickman, Adam M, additional, Carmichael, Owen, additional, Chakravarty, M Mallar, additional, Chauhan, Ganesh, additional, Chen, Qiang, additional, Ching, Christopher R K, additional, Cuellar-Partida, Gabriel, additional, Braber, Anouk Den, additional, Doan, Nhat Trung, additional, Ehrlich, Stefan, additional, Filippi, Irina, additional, Ge, Tian, additional, Giddaluru, Sudheer, additional, Goldman, Aaron L, additional, Gottesman, Rebecca F, additional, Greven, Corina U, additional, Grimm, Oliver, additional, Griswold, Michael E, additional, Guadalupe, Tulio, additional, Hass, Johanna, additional, Haukvik, Unn K, additional, Hilal, Saima, additional, Hofer, Edith, additional, Hoehn, David, additional, Holmes, Avram J, additional, Hoogman, Martine, additional, Janowitz, Deborah, additional, Jia, Tianye, additional, Kasperaviciute, Dalia, additional, Kim, Sungeun, additional, Klein, Marieke, additional, Kraemer, Bernd, additional, Lee, Phil H, additional, Liao, Jiemin, additional, Liewald, David C M, additional, Lopez, Lorna M, additional, Luciano, Michelle, additional, Macare, Christine, additional, Marquand, Andre, additional, Matarin, Mar, additional, Mather, Karen A, additional, Mattheisen, Manuel, additional, Mazoyer, Bernard, additional, McKay, David R, additional, McWhirter, Rebekah, additional, Milaneschi, Yuri, additional, Mirza-Schreiber, Nazanin, additional, Muetzel, Ryan L, additional, Maniega, Susana Muñoz, additional, Nho, Kwangsik, additional, Nugent, Allison C, additional, Loohuis, Loes M Olde, additional, Oosterlaan, Jaap, additional, Papmeyer, Martina, additional, Pappa, Irene, additional, Pirpamer, Lukas, additional, Pudas, Sara, additional, Pütz, Benno, additional, Rajan, Kumar B, additional, Ramasamy, Adaikalavan, additional, Richards, Jennifer S, additional, Risacher, Shannon L, additional, Roiz-Santiañez, Roberto, additional, Rommelse, Nanda, additional, Rose, Emma J, additional, Royle, Natalie A, additional, Rundek, Tatjana, additional, Sämann, Philipp G, additional, Satizabal, Claudia L, additional, Schmaal, Lianne, additional, Schork, Andrew J, additional, Shen, Li, additional, Shin, Jean, additional, Shumskaya, Elena, additional, Smith, Albert V, additional, Sprooten, Emma, additional, Strike, Lachlan T, additional, Teumer, Alexander, additional, Thomson, Russell, additional, Tordesillas-Gutierrez, Diana, additional, Toro, Roberto, additional, Trabzuni, Daniah, additional, Vaidya, Dhananjay, additional, Van der Grond, Jeroen, additional, Van der Meer, Dennis, additional, Van Donkelaar, Marjolein M J, additional, Van Eijk, Kristel R, additional, Van Erp, Theo G M, additional, Van Rooij, Daan, additional, Walton, Esther, additional, Westlye, Lars T, additional, Whelan, Christopher D, additional, Windham, Beverly G, additional, Winkler, Anderson M, additional, Woldehawariat, Girma, additional, Wolf, Christiane, additional, Wolfers, Thomas, additional, Xu, Bing, additional, Yanek, Lisa R, additional, Yang, Jingyun, additional, Zijdenbos, Alex, additional, Zwiers, Marcel P, additional, Agartz, Ingrid, additional, Aggarwal, Neelum T, additional, Almasy, Laura, additional, Ames, David, additional, Amouyel, Philippe, additional, Andreassen, Ole A, additional, Arepalli, Sampath, additional, Assareh, Amelia A, additional, Barral, Sandra, additional, Bastin, Mark E, additional, Becker, Diane M, additional, Becker, James T, additional, Bennett, David A, additional, Blangero, John, additional, van Bokhoven, Hans, additional, Boomsma, Dorret I, additional, Brodaty, Henry, additional, Brouwer, Rachel M, additional, Brunner, Han G, additional, Buckner, Randy L, additional, Buitelaar, Jan K, additional, Bulayeva, Kazima B, additional, Cahn, Wiepke, additional, Calhoun, Vince D, additional, Cannon, Dara M, additional, Cavalleri, Gianpiero L, additional, Chen, Christopher, additional, Cheng, Ching-Yu, additional, Cichon, Sven, additional, Cookson, Mark R, additional, Corvin, Aiden, additional, Crespo-Facorro, Benedicto, additional, Curran, Joanne E, additional, Czisch, Michael, additional, Dale, Anders M, additional, Davies, Gareth E, additional, De Geus, Eco J C, additional, De Jager, Philip L, additional, de Zubicaray, Greig I, additional, Delanty, Norman, additional, Depondt, Chantal, additional, DeStefano, Anita L, additional, Dillman, Allissa, additional, Djurovic, Srdjan, additional, Donohoe, Gary, additional, Drevets, Wayne C, additional, Duggirala, Ravi, additional, Dyer, Thomas D, additional, Erk, Susanne, additional, Espeseth, Thomas, additional, Evans, Denis A, additional, Fedko, Iryna O, additional, Fernández, Guillén, additional, Ferrucci, Luigi, additional, Fisher, Simon E, additional, Fleischman, Debra A, additional, Ford, Ian, additional, Foroud, Tatiana M, additional, Fox, Peter T, additional, Francks, Clyde, additional, Fukunaga, Masaki, additional, Gibbs, J Raphael, additional, Glahn, David C, additional, Gollub, Randy L, additional, Göring, Harald H H, additional, Grabe, Hans J, additional, Green, Robert C, additional, Gruber, Oliver, additional, Gudnason, Vilmundur, additional, Guelfi, Sebastian, additional, Hansell, Narelle K, additional, Hardy, John, additional, Hartman, Catharina A, additional, Hashimoto, Ryota, additional, Hegenscheid, Katrin, additional, Heinz, Andreas, additional, Le Hellard, Stephanie, additional, Hernandez, Dena G, additional, Heslenfeld, Dirk J, additional, Ho, Beng-Choon, additional, Hoekstra, Pieter J, additional, Hoffmann, Wolfgang, additional, Hofman, Albert, additional, Holsboer, Florian, additional, Homuth, Georg, additional, Hosten, Norbert, additional, Hottenga, Jouke-Jan, additional, Hulshoff Pol, Hilleke E, additional, Ikeda, Masashi, additional, Ikram, M Kamran, additional, Jack, Clifford R, additional, Jenkinson, Mark, additional, Johnson, Robert, additional, Jönsson, Erik G, additional, Jukema, J Wouter, additional, Kahn, René S, additional, Kanai, Ryota, additional, Kloszewska, Iwona, additional, Knopman, David S, additional, Kochunov, Peter, additional, Kwok, John B, additional, Lawrie, Stephen M, additional, Lemaître, Hervé, additional, Liu, Xinmin, additional, Longo, Dan L, additional, Longstreth, W T, additional, Lopez, Oscar L, additional, Lovestone, Simon, additional, Martinez, Oliver, additional, Martinot, Jean-Luc, additional, Mattay, Venkata S, additional, McDonald, Colm, additional, McIntosh, Andrew M, additional, McMahon, Katie L, additional, McMahon, Francis J, additional, Mecocci, Patrizia, additional, Melle, Ingrid, additional, Meyer-Lindenberg, Andreas, additional, Mohnke, Sebastian, additional, Montgomery, Grant W, additional, Morris, Derek W, additional, Mosley, Thomas H, additional, Mühleisen, Thomas W, additional, Müller-Myhsok, Bertram, additional, Nalls, Michael A, additional, Nauck, Matthias, additional, Nichols, Thomas E, additional, Niessen, Wiro J, additional, Nöthen, Markus M, additional, Nyberg, Lars, additional, Ohi, Kazutaka, additional, Olvera, Rene L, additional, Ophoff, Roel A, additional, Pandolfo, Massimo, additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Penninx, Brenda W J H, additional, Pike, G Bruce, additional, Potkin, Steven G, additional, Psaty, Bruce M, additional, Reppermund, Simone, additional, Rietschel, Marcella, additional, Roffman, Joshua L, additional, Romanczuk-Seiferth, Nina, additional, Rotter, Jerome I, additional, Ryten, Mina, additional, Sacco, Ralph L, additional, Sachdev, Perminder S, additional, Saykin, Andrew J, additional, Schmidt, Reinhold, additional, Schofield, Peter R, additional, Sigurdsson, Sigurdur, additional, Simmons, Andy, additional, Singleton, Andrew, additional, Sisodiya, Sanjay M, additional, Smith, Colin, additional, Smoller, Jordan W, additional, Soininen, Hilkka, additional, Srikanth, Velandai, additional, Steen, Vidar M, additional, Stott, David J, additional, Sussmann, Jessika E, additional, Thalamuthu, Anbupalam, additional, Tiemeier, Henning, additional, Toga, Arthur W, additional, Traynor, Bryan J, additional, Troncoso, Juan, additional, Turner, Jessica A, additional, Tzourio, Christophe, additional, Uitterlinden, Andre G, additional, Hernández, Maria C Valdés, additional, Van der Brug, Marcel, additional, Van der Lugt, Aad, additional, Van der Wee, Nic J A, additional, Van Duijn, Cornelia M, additional, Van Haren, Neeltje E M, additional, Van ′t Ent, Dennis, additional, Van Tol, Marie-Jose, additional, Vardarajan, Badri N, additional, Veltman, Dick J, additional, Vernooij, Meike W, additional, Völzke, Henry, additional, Walter, Henrik, additional, Wardlaw, Joanna M, additional, Wassink, Thomas H, additional, Weale, Michael E, additional, Weinberger, Daniel R, additional, Weiner, Michael W, additional, Wen, Wei, additional, Westman, Eric, additional, White, Tonya, additional, Wong, Tien Y, additional, Wright, Clinton B, additional, Zielke, H Ronald, additional, Zonderman, Alan B, additional, Deary, Ian J, additional, DeCarli, Charles, additional, Schmidt, Helena, additional, Martin, Nicholas G, additional, De Craen, Anton J M, additional, Wright, Margaret J, additional, Launer, Lenore J, additional, Schumann, Gunter, additional, Fornage, Myriam, additional, Franke, Barbara, additional, Debette, Stéphanie, additional, Medland, Sarah E, additional, Ikram, M Arfan, additional, and Thompson, Paul M, additional

Published
2016
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34. PLD3 and sporadic Alzheimer's disease risk

Author

Lambert, Jean-Charles, primary, Grenier-Boley, Benjamin, additional, Bellenguez, Céline, additional, Pasquier, Florence, additional, Campion, Dominique, additional, Dartigues, Jean-Francois, additional, Berr, Claudine, additional, Tzourio, Christophe, additional, and Amouyel, Philippe, additional

Published
2015
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43. An automated procedure for the assessment of white matter hyperintensities by multispectral (T1, T2, PD) MRI and an evaluation of its between-centre reproducibility based on two large community databases

Author

Maillard, Pauline, primary, Delcroix, Nicolas, additional, Crivello, Fabrice, additional, Dufouil, Carole, additional, Gicquel, Sebastien, additional, Joliot, Marc, additional, Tzourio-Mazoyer, Nathalie, additional, Alpérovitch, Annick, additional, Tzourio, Christophe, additional, and Mazoyer, Bernard, additional

Published
2007
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44. Parkinson's disease, smoking and family history

Author

Elbaz, Alexis, primary, Manubens-Bertran, José Maria, additional, Baldereschi, Marzia, additional, Breteler, Monique M.B., additional, Grigoletto, Francesco, additional, Lopez-Pousa, Secundino, additional, Dartigues, Jean-François, additional, Alpérovitch, Annik, additional, Rocca, Walter A., additional, and Tzourio, Christophe, additional

Published
2000
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46. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Author

Franceschini, Nora, Giambartolomei, Claudia, De Vries, Paul S, Finan, Chris, Bis, Joshua C, Huntley, Rachael P, Lovering, Ruth C, Tajuddin, Salman M, Winkler, Thomas W, Graff, Misa, Kavousi, Maryam, Dale, Caroline, Smith, Albert V, Hofer, Edith, Van Leeuwen, Elisabeth M, Nolte, Ilja M, Lu, Lingyi, Scholz, Markus, Sargurupremraj, Muralidharan, Pitkänen, Niina, Franzén, Oscar, Joshi, Peter K, Noordam, Raymond, Marioni, Riccardo E, Hwang, Shih-Jen, Musani, Solomon K, Schminke, Ulf, Palmas, Walter, Isaacs, Aaron, Correa, Adolfo, Zonderman, Alan B, Hofman, Albert, Teumer, Alexander, Cox, Amanda J, Uitterlinden, André G, Wong, Andrew, Smit, Andries J, Newman, Anne B, Britton, Annie, Ruusalepp, Arno, Sennblad, Bengt, Hedblad, Bo, Pasaniuc, Bogdan, Penninx, Brenda W, Langefeld, Carl D, Wassel, Christina L, Tzourio, Christophe, Fava, Cristiano, Baldassarre, Damiano, O'Leary, Daniel H, Teupser, Daniel, Kuh, Diana, Tremoli, Elena, Mannarino, Elmo, Grossi, Enzo, Boerwinkle, Eric, Schadt, Eric E, Ingelsson, Erik, Veglia, Fabrizio, Rivadeneira, Fernando, Beutner, Frank, Chauhan, Ganesh, Heiss, Gerardo, Snieder, Harold, Campbell, Harry, Völzke, Henry, Markus, Hugh S, Deary, Ian J, Jukema, J Wouter, De Graaf, Jacqueline, Price, Jacqueline, Pott, Janne, Hopewell, Jemma C, Liang, Jingjing, Thiery, Joachim, Engmann, Jorgen, Gertow, Karl, Rice, Kenneth, Taylor, Kent D, Dhana, Klodian, Kiemeney, Lambertus ALM, Lind, Lars, Raffield, Laura M, Launer, Lenore J, Holdt, Lesca M, Dörr, Marcus, Dichgans, Martin, Traylor, Matthew, Sitzer, Matthias, Kumari, Meena, Kivimaki, Mika, Nalls, Mike A, Melander, Olle, Raitakari, Olli, Franco, Oscar H, Rueda-Ochoa, Oscar L, Roussos, Panos, Whincup, Peter H, Amouyel, Philippe, Giral, Philippe, Anugu, Pramod, Wong, Quenna, Malik, Rainer, Rauramaa, Rainer, Burkhardt, Ralph, Hardy, Rebecca, Schmidt, Reinhold, De Mutsert, Renée, Morris, Richard W, Strawbridge, Rona J, Wannamethee, S Goya, Hägg, Sara, Shah, Sonia, McLachlan, Stela, Trompet, Stella, Seshadri, Sudha, Kurl, Sudhir, Heckbert, Susan R, Ring, Susan, Harris, Tamara B, Lehtimäki, Terho, Galesloot, Tessel E, Shah, Tina, De Faire, Ulf, Plagnol, Vincent, Rosamond, Wayne D, Post, Wendy, Zhu, Xiaofeng, Zhang, Xiaoling, Guo, Xiuqing, Saba, Yasaman, MEGASTROKE Consortium, Dehghan, Abbas, Seldenrijk, Adrie, Morrison, Alanna C, Hamsten, Anders, Psaty, Bruce M, Van Duijn, Cornelia M, Lawlor, Deborah A, Mook-Kanamori, Dennis O, Bowden, Donald W, Schmidt, Helena, Wilson, James F, Wilson, James G, Rotter, Jerome I, Wardlaw, Joanna M, Deanfield, John, Halcox, Julian, Lyytikäinen, Leo-Pekka, Loeffler, Markus, Evans, Michele K, Debette, Stéphanie, Humphries, Steve E, Völker, Uwe, Gudnason, Vilmundur, Hingorani, Aroon D, Björkegren, Johan LM, Casas, Juan P, and O'Donnell, Christopher J

Subjects
Quantitative Trait Loci, ADAMTS9 Protein, Coronary Disease, Carotid Intima-Media Thickness, Polymorphism, Single Nucleotide, Plaque, Atherosclerotic, 3. Good health, Protein-Lysine 6-Oxidase, Risk Factors, cardiovascular system, Humans, Genetic Predisposition to Disease, cardiovascular diseases, Amino Acid Oxidoreductases, Lod Score, Genome-Wide Association Study
Abstract

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.

47. Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

Author

Chibnik, Lori B, Wolters, Frank J, Bäckman, Kristoffer, Beiser, Alexa, Berr, Claudine, Bis, Joshua C, Boerwinkle, Eric, Bos, Daniel, Brayne, Carol, Dartigues, Jean-Francois, Darweesh, Sirwan KL, Debette, Stephanie, Davis-Plourde, Kendra L, Dufouil, Carole, Fornage, Myriam, Grasset, Leslie, Gudnason, Vilmundur, Hadjichrysanthou, Christoforos, Helmer, Catherine, Ikram, M Arfan, Ikram, M Kamran, Kern, Silke, Kuller, Lewis H, Launer, Lenore, Lopez, Oscar L, Matthews, Fiona, Meirelles, Osorio, Mosley, Thomas, Ower, Alison, Psaty, Bruce M, Satizabal, Claudia L, Seshadri, Sudha, Skoog, Ingmar, Stephan, Blossom CM, Tzourio, Christophe, Waziry, Reem, Wong, Mei Mei, Zettergren, Anna, and Hofman, Albert

Subjects
Aged, 80 and over, Male, Epidemiology, Incidence, 3. Good health, Cohort Studies, Alzheimer Disease, Population Surveillance, Humans, Dementia, Female, Gene-Environment Interaction, Prospective Studies, Cohort analysis, Consortium, Aged, Proportional Hazards Models
Abstract

Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence.

48. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Author

Sims, Rebecca, Van Der Lee, Sven J, Naj, Adam C, Bellenguez, Céline, Badarinarayan, Nandini, Jakobsdottir, Johanna, Kunkle, Brian W, Boland, Anne, Raybould, Rachel, Bis, Joshua C, Martin, Eden R, Grenier-Boley, Benjamin, Heilmann-Heimbach, Stefanie, Chouraki, Vincent, Kuzma, Amanda B, Sleegers, Kristel, Vronskaya, Maria, Ruiz, Agustin, Graham, Robert R, Olaso, Robert, Hoffmann, Per, Grove, Megan L, Vardarajan, Badri N, Hiltunen, Mikko, Nöthen, Markus M, White, Charles C, Hamilton-Nelson, Kara L, Epelbaum, Jacques, Maier, Wolfgang, Choi, Seung-Hoan, Beecham, Gary W, Dulary, Cécile, Herms, Stefan, Smith, Albert V, Funk, Cory C, Derbois, Céline, Forstner, Andreas J, Ahmad, Shahzad, Li, Hongdong, Bacq, Delphine, Harold, Denise, Satizabal, Claudia L, Valladares, Otto, Squassina, Alessio, Thomas, Rhodri, Brody, Jennifer A, Qu, Liming, Sánchez-Juan, Pascual, Morgan, Taniesha, Wolters, Frank J, Zhao, Yi, Garcia, Florentino Sanchez, Denning, Nicola, Fornage, Myriam, Malamon, John, Naranjo, Maria Candida Deniz, Majounie, Elisa, Mosley, Thomas H, Dombroski, Beth, Wallon, David, Lupton, Michelle K, Dupuis, Josée, Whitehead, Patrice, Fratiglioni, Laura, Medway, Christopher, Jian, Xueqiu, Mukherjee, Shubhabrata, Keller, Lina, Brown, Kristelle, Lin, Honghuang, Cantwell, Laura B, Panza, Francesco, McGuinness, Bernadette, Moreno-Grau, Sonia, Burgess, Jeremy D, Solfrizzi, Vincenzo, Proitsi, Petra, Adams, Hieab H, Allen, Mariet, Seripa, Davide, Pastor, Pau, Cupples, L Adrienne, Price, Nathan D, Hannequin, Didier, Frank-García, Ana, Levy, Daniel, Chakrabarty, Paramita, Caffarra, Paolo, Giegling, Ina, Beiser, Alexa S, Giedraitis, Vilmantas, Hampel, Harald, Garcia, Melissa E, Wang, Xue, Lannfelt, Lars, Mecocci, Patrizia, Eiriksdottir, Gudny, Crane, Paul K, Pasquier, Florence, Boccardi, Virginia, Henández, Isabel, Barber, Robert C, Scherer, Martin, Tarraga, Lluis, Adams, Perrie M, Leber, Markus, Chen, Yuning, Albert, Marilyn S, Riedel-Heller, Steffi, Emilsson, Valur, Beekly, Duane, Braae, Anne, Schmidt, Reinhold, Blacker, Deborah, Masullo, Carlo, Schmidt, Helena, Doody, Rachelle S, Spalletta, Gianfranco, Longstreth, WT, Fairchild, Thomas J, Bossù, Paola, Lopez, Oscar L, Frosch, Matthew P, Sacchinelli, Eleonora, Ghetti, Bernardino, Yang, Qiong, Huebinger, Ryan M, Jessen, Frank, Li, Shuo, Kamboh, M Ilyas, Morris, John, Sotolongo-Grau, Oscar, Katz, Mindy J, Corcoran, Chris, Dunstan, Melanie, Braddel, Amy, Thomas, Charlene, Meggy, Alun, Marshall, Rachel, Gerrish, Amy, Chapman, Jade, Aguilar, Miquel, Taylor, Sarah, Hill, Matt, Fairén, Mònica Díez, Hodges, Angela, Vellas, Bruno, Soininen, Hilkka, Kloszewska, Iwona, Daniilidou, Makrina, Uphill, James, Patel, Yogen, Hughes, Joseph T, Lord, Jenny, Turton, James, Hartmann, Annette M, Cecchetti, Roberta, Fenoglio, Chiara, Serpente, Maria, Arcaro, Marina, Caltagirone, Carlo, Orfei, Maria Donata, Ciaramella, Antonio, Pichler, Sabrina, Mayhaus, Manuel, Gu, Wei, Lleó, Alberto, Fortea, Juan, Blesa, Rafael, Barber, Imelda S, Brookes, Keeley, Cupidi, Chiara, Maletta, Raffaele Giovanni, Carrell, David, Sorbi, Sandro, Moebus, Susanne, Urbano, Maria, Pilotto, Alberto, Kornhuber, Johannes, Bosco, Paolo, Todd, Stephen, Craig, David, Johnston, Janet, Gill, Michael, Lawlor, Brian, Lynch, Aoibhinn, Fox, Nick C, Hardy, John, ARUK Consortium, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Asthana, Sanjay, Atwood, Craig S, Baldwin, Clinton T, Barnes, Lisa L, Barral, Sandra, Beach, Thomas G, Becker, James T, Bigio, Eileen H, Bird, Thomas D, Boeve, Bradley F, Bowen, James D, Boxer, Adam, Burke, James R, Burns, Jeffrey M, Buxbaum, Joseph D, Cairns, Nigel J, Cao, Chuanhai, Carlson, Chris S, Carlsson, Cynthia M, Carney, Regina M, Carrasquillo, Minerva M, Carroll, Steven L, Diaz, Carolina Ceballos, Chui, Helena C, Clark, David G, Cribbs, David H, Crocco, Elizabeth A, DeCarli, Charles, Dick, Malcolm, Duara, Ranjan, Evans, Denis A, Faber, Kelley M, Fallon, Kenneth B, Fardo, David W, Farlow, Martin R, Ferris, Steven, Foroud, Tatiana M, Galasko, Douglas R, Gearing, Marla, Geschwind, Daniel H, Gilbert, John R, Graff-Radford, Neill R, Green, Robert C, Growdon, John H, Hamilton, Ronald L, Harrell, Lindy E, Honig, Lawrence S, Huentelman, Matthew J, Hulette, Christine M, Hyman, Bradley T, Jarvik, Gail P, Abner, Erin, Jin, Lee-Way, Jun, Gyungah, Karydas, Anna, Kaye, Jeffrey A, Kim, Ronald, Kowall, Neil W, Kramer, Joel H, LaFerla, Frank M, Lah, James J, Leverenz, James B, Levey, Allan I, Li, Ge, Lieberman, Andrew P, Lunetta, Kathryn L, Lyketsos, Constantine G, Marson, Daniel C, Martiniuk, Frank, Mash, Deborah C, Masliah, Eliezer, McCormick, Wayne C, McCurry, Susan M, McDavid, Andrew N, McKee, Ann C, Mesulam, Marsel, Miller, Bruce L, Miller, Carol A, Miller, Joshua W, Morris, John C, Murrell, Jill R, Myers, Amanda J, O'Bryant, Sid, Olichney, John M, Pankratz, Vernon S, Parisi, Joseph E, Paulson, Henry L, Perry, William, Peskind, Elaine, Pierce, Aimee, Poon, Wayne W, Potter, Huntington, Quinn, Joseph F, Raj, Ashok, Raskind, Murray, Reisberg, Barry, Reitz, Christiane, Ringman, John M, Roberson, Erik D, Rogaeva, Ekaterina, Rosen, Howard J, Rosenberg, Roger N, Sager, Mark A, Saykin, Andrew J, Schneider, Julie A, Schneider, Lon S, Seeley, William W, Smith, Amanda G, Sonnen, Joshua A, Spina, Salvatore, Stern, Robert A, Swerdlow, Russell H, Tanzi, Rudolph E, Thornton-Wells, Tricia A, Trojanowski, John Q, Troncoso, Juan C, Van Deerlin, Vivianna M, Van Eldik, Linda J, Vinters, Harry V, Vonsattel, Jean Paul, Weintraub, Sandra, Welsh-Bohmer, Kathleen A, Wilhelmsen, Kirk C, Williamson, Jennifer, Wingo, Thomas S, Woltjer, Randall L, Wright, Clinton B, Yu, Chang-En, Yu, Lei, Garzia, Fabienne, Golamaully, Feroze, Septier, Gislain, Engelborghs, Sebastien, Vandenberghe, Rik, De Deyn, Peter P, Fernadez, Carmen Muñoz, Benito, Yoland Aladro, Thonberg, Hakan, Forsell, Charlotte, Lilius, Lena, Kinhult-Stählbom, Anne, Kilander, Lena, Brundin, RoseMarie, Concari, Letizia, Helisalmi, Seppo, Koivisto, Anne Maria, Haapasalo, Annakaisa, Dermecourt, Vincent, Fievet, Nathalie, Hanon, Olivier, Dufouil, Carole, Brice, Alexis, Ritchie, Karen, Dubois, Bruno, Himali, Jayanadra J, Keene, C Dirk, Tschanz, JoAnn, Fitzpatrick, Annette L, Kukull, Walter A, Norton, Maria, Aspelund, Thor, Larson, Eric B, Munger, Ron, Rotter, Jerome I, Lipton, Richard B, Bullido, María J, Hofman, Albert, Montine, Thomas J, Coto, Eliecer, Boerwinkle, Eric, Petersen, Ronald C, Alvarez, Victoria, Rivadeneira, Fernando, Reiman, Eric M, Gallo, Maura, O'Donnell, Christopher J, Reisch, Joan S, Bruni, Amalia Cecilia, Royall, Donald R, Dichgans, Martin, Sano, Mary, Galimberti, Daniela, St George-Hyslop, Peter, Scarpini, Elio, Tsuang, Debby W, Mancuso, Michelangelo, Bonuccelli, Ubaldo, Winslow, Ashley R, Daniele, Antonio, Wu, Chuang-Kuo, GERAD/PERADES, CHARGE, Peters, Oliver, Nacmias, Benedetta, Riemenschneider, Matthias, Heun, Reinhard, Brayne, Carol, Rubinsztein, David C, Bras, Jose, Guerreiro, Rita, Al-Chalabi, Ammar, Shaw, Christopher E, Collinge, John, Mann, David, Tsolaki, Magda, Clarimón, Jordi, Sussams, Rebecca, Lovestone, Simon, O'Donovan, Michael C, Owen, Michael J, Behrens, Timothy W, Mead, Simon, Goate, Alison M, Uitterlinden, Andre G, Holmes, Clive, Cruchaga, Carlos, Ingelsson, Martin, Bennett, David A, Powell, John, Golde, Todd E, Graff, Caroline, De Jager, Philip L, Morgan, Kevin, Ertekin-Taner, Nilufer, Combarros, Onofre, Psaty, Bruce M, Passmore, Peter, Younkin, Steven G, Berr, Claudine, Gudnason, Vilmundur, Rujescu, Dan, Dickson, Dennis W, Dartigues, Jean-François, DeStefano, Anita L, Ortega-Cubero, Sara, Hakonarson, Hakon, Campion, Dominique, Boada, Merce, Kauwe, John Keoni, Farrer, Lindsay A, Van Broeckhoven, Christine, Ikram, M Arfan, Jones, Lesley, Haines, Jonathan L, Tzourio, Christophe, Launer, Lenore J, Escott-Price, Valentina, Mayeux, Richard, Deleuze, Jean-François, Amin, Najaf, Holmans, Peter A, Pericak-Vance, Margaret A, Amouyel, Philippe, Van Duijn, Cornelia M, Ramirez, Alfredo, Wang, Li-San, Lambert, Jean-Charles, Seshadri, Sudha, Williams, Julie, and Schellenberg, Gerard D

Subjects
Membrane Glycoproteins, Genotype, Sequence Homology, Amino Acid, Phospholipase C gamma, Gene Expression Profiling, Polymorphism, Single Nucleotide, Immunity, Innate, Linkage Disequilibrium, 3. Good health, Gene Frequency, Alzheimer Disease, Case-Control Studies, Odds Ratio, Humans, Exome, Genetic Predisposition to Disease, Amino Acid Sequence, Microglia, Protein Interaction Maps, Receptors, Immunologic, Adaptor Proteins, Signal Transducing
Abstract

We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, we used an additional 14,997 samples to test the most significant stage 2 associations (P < 5 × 10-8) using imputed genotypes. We observed three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease: a protective variant in PLCG2 (rs72824905: p.Pro522Arg, P = 5.38 × 10-10, odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols = 0.0093), a risk variant in ABI3 (rs616338: p.Ser209Phe, P = 4.56 × 10-10, OR = 1.43, MAFcases = 0.011, MAFcontrols = 0.008), and a new genome-wide significant variant in TREM2 (rs143332484: p.Arg62His, P = 1.55 × 10-14, OR = 1.67, MAFcases = 0.0143, MAFcontrols = 0.0089), a known susceptibility gene for Alzheimer's disease. These protein-altering changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified risk genes in Alzheimer's disease. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's disease.

49. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Author

Malik, Rainer, Chauhan, Ganesh, Traylor, Matthew, Sargurupremraj, Muralidharan, Okada, Yukinori, Mishra, Aniket, Rutten-Jacobs, Loes, Giese, Anne-Katrin, Van Der Laan, Sander W, Gretarsdottir, Solveig, Anderson, Christopher D, Chong, Michael, Adams, Hieab HH, Ago, Tetsuro, Almgren, Peter, Amouyel, Philippe, Ay, Hakan, Bartz, Traci M, Benavente, Oscar R, Bevan, Steve, Boncoraglio, Giorgio B, Brown, Robert D, Butterworth, Adam S, Carrera, Caty, Carty, Cara L, Chasman, Daniel I, Chen, Wei-Min, Cole, John W, Correa, Adolfo, Cotlarciuc, Ioana, Cruchaga, Carlos, Danesh, John, De Bakker, Paul IW, DeStefano, Anita L, Den Hoed, Marcel, Duan, Qing, Engelter, Stefan T, Falcone, Guido J, Gottesman, Rebecca F, Grewal, Raji P, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeffrey, Harris, Tamara B, Hassan, Ahamad, Havulinna, Aki S, Heckbert, Susan R, Holliday, Elizabeth G, Howard, George, Hsu, Fang-Chi, Hyacinth, Hyacinth I, Ikram, M Arfan, Ingelsson, Erik, Irvin, Marguerite R, Jian, Xueqiu, Jiménez-Conde, Jordi, Johnson, Julie A, Jukema, J Wouter, Kanai, Masahiro, Keene, Keith L, Kissela, Brett M, Kleindorfer, Dawn O, Kooperberg, Charles, Kubo, Michiaki, Lange, Leslie A, Langefeld, Carl D, Langenberg, Claudia, Launer, Lenore J, Lee, Jin-Moo, Lemmens, Robin, Leys, Didier, Lewis, Cathryn M, Lin, Wei-Yu, Lindgren, Arne G, Lorentzen, Erik, Magnusson, Patrik K, Maguire, Jane, Manichaikul, Ani, McArdle, Patrick F, Meschia, James F, Mitchell, Braxton D, Mosley, Thomas H, Nalls, Michael A, Ninomiya, Toshiharu, O'Donnell, Martin J, Psaty, Bruce M, Pulit, Sara L, Rannikmäe, Kristiina, Reiner, Alexander P, Rexrode, Kathryn M, Rice, Kenneth, Rich, Stephen S, Ridker, Paul M, Rost, Natalia S, Rothwell, Peter M, Rotter, Jerome I, Rundek, Tatjana, Sacco, Ralph L, Sakaue, Saori, Sale, Michele M, Salomaa, Veikko, Sapkota, Bishwa R, Schmidt, Reinhold, Schmidt, Carsten O, Schminke, Ulf, Sharma, Pankaj, Slowik, Agnieszka, Sudlow, Cathie LM, Tanislav, Christian, Tatlisumak, Turgut, Taylor, Kent D, Thijs, Vincent NS, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Tiedt, Steffen, Trompet, Stella, Tzourio, Christophe, Van Duijn, Cornelia M, Walters, Matthew, Wareham, Nicholas J, Wassertheil-Smoller, Sylvia, Wilson, James G, Wiggins, Kerri L, Yang, Qiong, Yusuf, Salim, AFGen Consortium, Cohorts For Heart And Aging Research In Genomic Epidemiology (CHARGE) Consortium, International Genomics Of Blood Pressure (IGEN-BP) Consortium, INVENT Consortium, STARNET, Bis, Joshua C, Pastinen, Tomi, Ruusalepp, Arno, Schadt, Eric E, Koplev, Simon, Björkegren, Johan LM, Codoni, Veronica, Civelek, Mete, Smith, Nicholas L, Trégouët, David A, Christophersen, Ingrid E, Roselli, Carolina, Lubitz, Steven A, Ellinor, Patrick T, Tai, E Shyong, Kooner, Jaspal S, Kato, Norihiro, He, Jiang, Van Der Harst, Pim, Elliott, Paul, Chambers, John C, Takeuchi, Fumihiko, Johnson, Andrew D, BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC), METASTROKE Consortium, Neurology Working Group Of The CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGASTROKE Consortium, Sanghera, Dharambir K, Melander, Olle, Jern, Christina, Strbian, Daniel, Fernandez-Cadenas, Israel, Longstreth, WT, Rolfs, Arndt, Hata, Jun, Woo, Daniel, Rosand, Jonathan, Pare, Guillaume, Hopewell, Jemma C, Saleheen, Danish, Stefansson, Kari, Worrall, Bradford B, Kittner, Steven J, Seshadri, Sudha, Fornage, Myriam, Markus, Hugh S, Howson, Joanna MM, Kamatani, Yoichiro, Debette, Stephanie, and Dichgans, Martin

Subjects
Male, Models, Genetic, Computational Biology, Polymorphism, Single Nucleotide, Linkage Disequilibrium, 3. Good health, Epigenesis, Genetic, Stroke, INDEL Mutation, Genetic Loci, Risk Factors, Databases, Genetic, Humans, Female, Gene Regulatory Networks, Genetic Predisposition to Disease, Genome-Wide Association Study
Abstract

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.

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