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14 results on '"Tyrer, Jonathan P"'

1. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Author

Ho, Weang-Kee, primary, Tan, Min-Min, additional, Mavaddat, Nasim, additional, Tai, Mei-Chee, additional, Mariapun, Shivaani, additional, Li, Jingmei, additional, Ho, Peh-Joo, additional, Dennis, Joe, additional, Tyrer, Jonathan P., additional, Bolla, Manjeet K., additional, Michailidou, Kyriaki, additional, Wang, Qin, additional, Kang, Daehee, additional, Choi, Ji-Yeob, additional, Jamaris, Suniza, additional, Shu, Xiao-Ou, additional, Yoon, Sook-Yee, additional, Park, Sue K., additional, Kim, Sung-Won, additional, Shen, Chen-Yang, additional, Yu, Jyh-Cherng, additional, Tan, Ern Yu, additional, Chan, Patrick Mun Yew, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Wu, Anna H., additional, Stram, Daniel O., additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Chan, Ching Wan, additional, Ngeow, Joanne, additional, Yong, Wei Sean, additional, Lim, Swee Ho, additional, Lim, Geok Hoon, additional, Kwong, Ava, additional, Chan, Tsun L., additional, Tan, Su Ming, additional, Seah, Jaime, additional, John, Esther M., additional, Kurian, Allison W., additional, Koh, Woon-Puay, additional, Khor, Chiea Chuen, additional, Iwasaki, Motoki, additional, Yamaji, Taiki, additional, Tan, Kiak Mien Veronique, additional, Tan, Kiat Tee Benita, additional, Spinelli, John J., additional, Aronson, Kristan J., additional, Hasan, Siti Norhidayu, additional, Rahmat, Kartini, additional, Vijayananthan, Anushya, additional, Sim, Xueling, additional, Pharoah, Paul D. P., additional, Zheng, Wei, additional, Dunning, Alison M., additional, Simard, Jacques, additional, van Dam, Rob Martinus, additional, Yip, Cheng-Har, additional, Taib, Nur Aishah Mohd, additional, Hartman, Mikael, additional, Easton, Douglas F., additional, Teo, Soo-Hwang, additional, and Antoniou, Antonis C., additional

Published
2020
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2. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C, Nagle, Christina M, Thrift, Aaron P, Pharoah, Paul DP, Ewing, Ailith, Pearce, Celeste Leigh, Zheng, Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Chang-Claude, Jenny, Jung, Audrey Y, Moysich, Kirsten B, Odunsi, Kunle, Goodman, Marc T, Wilkens, Lynne R, Thompson, Pamela J, Shvetsov, Yurii B, Dörk, Thilo, Park-Simon, Tjoung-Won, Hillemanns, Peter, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M, Leminen, Arto, Modugno, Francesmary, Ness, Roberta B, Edwards, Robert P, Kelley, Joseph L, Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Karlan, Beth Y, Lester, Jenny, Orsulic, Sandra, Rimel, Bobbie J, Kjær, Susanne K, Høgdall, Estrid, Jensen, Allan, Goode, Ellen L, Fridley, Brooke L, Cunningham, Julie M, Winham, Stacey J, Giles, Graham G, Bruinsma, Fiona, Milne, Roger L, Southey, Melissa C, Hildebrandt, Michelle AT, Wu, Xifeng, Lu, Karen H, Liang, Dong, Levine, Douglas A, Bisogna, Maria, Schildkraut, Joellen M, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Bandera, Elisa V, Olson, Sara H, Salvesen, Helga B, Thomsen, Liv Cecilie Vestrheim, Kopperud, Reidun K, Bjorge, Line, Kiemeney, Lambertus A, Massuger, Leon FAG, Pejovic, Tanja, Bruegl, Amanda, Cook, Linda S, Le, Nhu D, Swenerton, Kenneth D, Brooks-Wilson, Angela, Kelemen, Linda E, Lubiński, Jan, Huzarski, Tomasz, Gronwald, Jacek, Menkiszak, Janusz, Wentzensen, Nicolas, Brinton, Louise, Yang, Hannah, Lissowska, Jolanta, Høgdall, Claus K, Lundvall, Lene, Song, Honglin, Tyrer, Jonathan P, Campbell, Ian, Eccles, Diana, Paul, James, Glasspool, Rosalind, Siddiqui, Nadeem, Whittemore, Alice S, Sieh, Weiva, McGuire, Valerie, Rothstein, Joseph H, Narod, Steven A, Phelan, Catherine, Risch, Harvey A, McLaughlin, John R, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Wu, Anna H, Pike, Malcolm C, Tseng, Chiu-Chen, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Budzilowska, Agnieszka, Rzepecka, Iwona K, Webb, Penelope M, Ovarian Cancer Association Consortium, Dixon-Suen, Suzanne C [0000-0003-3714-8386], Zheng, Wei [0000-0003-1226-070X], Brinton, Louise [0000-0003-3853-8562], Glasspool, Rosalind [0000-0002-5000-1680], and Apollo - University of Cambridge Repository

Subjects
Adult, Aged, 80 and over, Ovarian Neoplasms, Adolescent, Geography, Carcinoma, Ovarian Epithelial, Mendelian Randomization Analysis, Middle Aged, Body Height, Young Adult, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Aged
Abstract

BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

Published
2018

3. Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, primary, Finucane, Hilary K., additional, Schumacher, Fredrick R., additional, Schmit, Stephanie L., additional, Tyrer, Jonathan P., additional, Han, Younghun, additional, Michailidou, Kyriaki, additional, Lesseur, Corina, additional, Kuchenbaecker, Karoline B., additional, Dennis, Joe, additional, Conti, David V., additional, Casey, Graham, additional, Gaudet, Mia M., additional, Huyghe, Jeroen R., additional, Albanes, Demetrius, additional, Aldrich, Melinda C., additional, Andrew, Angeline S., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antoniou, Antonis C., additional, Antonenkova, Natalia N., additional, Arnold, Susanne M., additional, Aronson, Kristan J., additional, Arun, Banu K., additional, Bandera, Elisa V., additional, Barkardottir, Rosa B., additional, Barnes, Daniel R., additional, Batra, Jyotsna, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Benlloch, Sara, additional, Berchuck, Andrew, additional, Berndt, Sonja I., additional, Bickeböller, Heike, additional, Bien, Stephanie A., additional, Blomqvist, Carl, additional, Boccia, Stefania, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brenton, James D., additional, Brook, Mark N., additional, Brunet, Joan, additional, Brunnström, Hans, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Cadoni, Gabriella, additional, Caldés, Trinidad, additional, Caligo, Maria A., additional, Campbell, Ian, additional, Campbell, Peter T., additional, Cancel-Tassin, Géraldine, additional, Cannon-Albright, Lisa, additional, Campa, Daniele, additional, Caporaso, Neil, additional, Carvalho, André L., additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Christiani, David C., additional, Claes, Kathleen B. M., additional, Claessens, Frank, additional, Clements, Judith, additional, Collée, J. Margriet, additional, Correa, Marcia Cruz, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Daly, Mary B., additional, deFazio, Anna, additional, Devilee, Peter, additional, Diez, Orland, additional, Gago-Dominguez, Manuela, additional, Donovan, Jenny L., additional, Dörk, Thilo, additional, Duell, Eric J., additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Edlund, Christopher K., additional, Edwards, Digna R. Velez, additional, Ellberg, Carolina, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Ferris, Robert L., additional, Liloglou, Triantafillos, additional, Figueiredo, Jane C., additional, Fletcher, Olivia, additional, Fortner, Renée T., additional, Fostira, Florentia, additional, Franceschi, Silvia, additional, Friedman, Eitan, additional, Gallinger, Steven J., additional, Ganz, Patricia A., additional, Garber, Judy, additional, García-Sáenz, José A., additional, Gayther, Simon A., additional, Giles, Graham G., additional, Godwin, Andrew K., additional, Goldberg, Mark S., additional, Goldgar, David E., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Goodman, Gary, additional, Grankvist, Kjell, additional, Greene, Mark H., additional, Gronberg, Henrik, additional, Gronwald, Jacek, additional, Guénel, Pascal, additional, Håkansson, Niclas, additional, Hall, Per, additional, Hamann, Ute, additional, Hamdy, Freddie C., additional, Hamilton, Robert J., additional, Hampe, Jochen, additional, Haugen, Aage, additional, Heitz, Florian, additional, Herrero, Rolando, additional, Hillemanns, Peter, additional, Hoffmeister, Michael, additional, Høgdall, Estrid, additional, Hong, Yun-Chul, additional, Hopper, John L., additional, Houlston, Richard, additional, Hulick, Peter J., additional, Hunter, David J., additional, Huntsman, David G., additional, Idos, Gregory, additional, Imyanitov, Evgeny N., additional, Ingles, Sue Ann, additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, James, Paul, additional, Jenkins, Mark A., additional, Johansson, Mattias, additional, Johansson, Mikael, additional, John, Esther M., additional, Joshi, Amit D., additional, Kaneva, Radka, additional, Karlan, Beth Y., additional, Kelemen, Linda E., additional, Kühl, Tabea, additional, Khaw, Kay-Tee, additional, Khusnutdinova, Elza, additional, Kibel, Adam S., additional, Kiemeney, Lambertus A., additional, Kim, Jeri, additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Kogevinas, Manolis, additional, Kote-Jarai, Zsofia, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Kupryjanczyk, Jolanta, additional, Lacko, Martin, additional, Lam, Stephan, additional, Lambrechts, Diether, additional, Landi, Maria Teresa, additional, Lazarus, Philip, additional, Le, Nhu D., additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lenz, Heinz-Josef, additional, Leslie, Goska, additional, Lessel, Davor, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Li, additional, Li, Christopher I., additional, Lindblom, Annika, additional, Lindor, Noralane M., additional, Liu, Geoffrey, additional, Loupakis, Fotios, additional, Lubiński, Jan, additional, Maehle, Lovise, additional, Maier, Christiane, additional, Mannermaa, Arto, additional, Marchand, Loic Le, additional, Margolin, Sara, additional, May, Taymaa, additional, McGuffog, Lesley, additional, Meindl, Alfons, additional, Middha, Pooja, additional, Miller, Austin, additional, Milne, Roger L., additional, MacInnis, Robert J., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moreno, Victor, additional, Moysich, Kirsten B., additional, Mucci, Lorelei, additional, Muir, Kenneth, additional, Mulligan, Anna Marie, additional, Nathanson, Katherine L., additional, Neal, David E., additional, Ness, Andrew R., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Newcomb, Polly A., additional, Newcomb, Lisa F., additional, Nielsen, Finn Cilius, additional, Nikitina-Zake, Liene, additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Offit, Kenneth, additional, Olah, Edith, additional, Olama, Ali Amin Al, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Olsson, Håkan, additional, Osorio, Ana, additional, Pandha, Hardev, additional, Park, Jong Y., additional, Pashayan, Nora, additional, Parsons, Michael T., additional, Pejovic, Tanja, additional, Penney, Kathryn L., additional, Peters, Wilbert H. M., additional, Phelan, Catherine M., additional, Phipps, Amanda I., additional, Plaseska-Karanfilska, Dijana, additional, Pring, Miranda, additional, Prokofyeva, Darya, additional, Radice, Paolo, additional, Stefansson, Kari, additional, Ramus, Susan J., additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, van Rensburg, Elizabeth J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Risch, Angela, additional, Roobol, Monique J., additional, Rosenstein, Barry S., additional, Rossing, Mary Anne, additional, De Ruyck, Kim, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schabath, Matthew B., additional, Schleutker, Johanna, additional, Schmidt, Marjanka K., additional, Setiawan, V. Wendy, additional, Shen, Hongbing, additional, Siegel, Erin M., additional, Sieh, Weiva, additional, Singer, Christian F., additional, Slattery, Martha L., additional, Sorensen, Karina Dalsgaard, additional, Southey, Melissa C., additional, Spurdle, Amanda B., additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stintzing, Sebastian, additional, Stone, Jennifer, additional, Sundfeldt, Karin, additional, Sutphen, Rebecca, additional, Swerdlow, Anthony J., additional, Tajara, Eloiza H., additional, Tangen, Catherine M., additional, Tardon, Adonina, additional, Taylor, Jack A., additional, Teare, M. Dawn, additional, Teixeira, Manuel R., additional, Terry, Mary Beth, additional, Terry, Kathryn L., additional, Thibodeau, Stephen N., additional, Thomassen, Mads, additional, Bjørge, Line, additional, Tischkowitz, Marc, additional, Toland, Amanda E., additional, Torres, Diana, additional, Townsend, Paul A., additional, Travis, Ruth C., additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Ulrich, Cornelia M., additional, Usmani, Nawaid, additional, Vachon, Celine M., additional, Van Nieuwenhuysen, Els, additional, Vega, Ana, additional, Aguado-Barrera, Miguel Elías, additional, Wang, Qin, additional, Webb, Penelope M., additional, Weinberg, Clarice R., additional, Weinstein, Stephanie, additional, Weissler, Mark C., additional, Weitzel, Jeffrey N., additional, West, Catharine M. L., additional, White, Emily, additional, Whittemore, Alice S., additional, Wichmann, H-Erich, additional, Wiklund, Fredrik, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Woll, Penella, additional, Woods, Michael, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yannoukakos, Drakoulis, additional, Zheng, Wei, additional, Zienolddiny, Shanbeh, additional, Ziogas, Argyrios, additional, Zorn, Kristin K., additional, Lane, Jacqueline M., additional, Saxena, Richa, additional, Thomas, Duncan, additional, Hung, Rayjean J., additional, Diergaarde, Brenda, additional, McKay, James, additional, Peters, Ulrike, additional, Hsu, Li, additional, García-Closas, Montserrat, additional, Eeles, Rosalind A., additional, Chenevix-Trench, Georgia, additional, Brennan, Paul J., additional, Haiman, Christopher A., additional, Simard, Jacques, additional, Easton, Douglas F., additional, Gruber, Stephen B., additional, Pharoah, Paul D. P., additional, Price, Alkes L., additional, Pasaniuc, Bogdan, additional, Amos, Christopher I., additional, Kraft, Peter, additional, and Lindström, Sara, additional

Published
2019
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4. Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, primary, Finucane, Hilary K., additional, Schumacher, Fredrick R., additional, Schmit, Stephanie L., additional, Tyrer, Jonathan P., additional, Han, Younghun, additional, Michailidou, Kyriaki, additional, Lesseur, Corina, additional, Kuchenbaecker, Karoline B., additional, Dennis, Joe, additional, Conti, David V., additional, Casey, Graham, additional, Gaudet, Mia M., additional, Huyghe, Jeroen R., additional, Albanes, Demetrius, additional, Aldrich, Melinda C., additional, Andrew, Angeline S., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antoniou, Antonis C., additional, Antonenkova, Natalia N., additional, Arnold, Susanne M., additional, Aronson, Kristan J., additional, Arun, Banu K., additional, Bandera, Elisa V., additional, Barkardottir, Rosa B., additional, Barnes, Daniel R., additional, Batra, Jyotsna, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Benlloch, Sara, additional, Berchuck, Andrew, additional, Berndt, Sonja I., additional, Bickeböller, Heike, additional, Bien, Stephanie A., additional, Blomqvist, Carl, additional, Boccia, Stefania, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brenton, James D., additional, Brook, Mark N., additional, Brunet, Joan, additional, Brunnström, Hans, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Cadoni, Gabriella, additional, Caldés, Trinidad, additional, Caligo, Maria A., additional, Campbell, Ian, additional, Campbell, Peter T., additional, Cancel-Tassin, Géraldine, additional, Cannon-Albright, Lisa, additional, Campa, Daniele, additional, Caporaso, Neil, additional, Carvalho, André L., additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Christiani, David C., additional, Claes, Kathleen B. M., additional, Claessens, Frank, additional, Clements, Judith, additional, Collée, J. Margriet, additional, Correa, Marcia Cruz, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Daly, Mary B., additional, deFazio, Anna, additional, Devilee, Peter, additional, Diez, Orland, additional, Gago-Dominguez, Manuela, additional, Donovan, Jenny L., additional, Dörk, Thilo, additional, Duell, Eric J., additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Edlund, Christopher K., additional, Edwards, Digna R Velez, additional, Ellberg, Carolina, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Ferris, Robert L., additional, Liloglou, Triantafillos, additional, Figueiredo, Jane C., additional, Fletcher, Olivia, additional, Fortner, Renée T., additional, Fostira, Florentia, additional, Franceschi, Silvia, additional, Friedman, Eitan, additional, Gallinger, Steven J., additional, Ganz, Patricia A., additional, Garber, Judy, additional, García-Sáenz, José A., additional, Gayther, Simon A., additional, Giles, Graham G., additional, Godwin, Andrew K., additional, Goldberg, Mark S., additional, Goldgar, David E., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Goodman, Gary, additional, Grankvist, Kjell, additional, Greene, Mark H., additional, Gronberg, Henrik, additional, Gronwald, Jacek, additional, Guénel, Pascal, additional, Håkansson, Niclas, additional, Hall, Per, additional, Hamann, Ute, additional, Hamdy, Freddie C., additional, Hamilton, Robert J., additional, Hampe, Jochen, additional, Haugen, Aage, additional, Heitz, Florian, additional, Herrero, Rolando, additional, Hillemanns, Peter, additional, Hoffmeister, Michael, additional, Høgdall, Estrid, additional, Hong, Yun-Chul, additional, Hopper, John L., additional, Houlston, Richard, additional, Hulick, Peter J., additional, Hunter, David J., additional, Huntsman, David G., additional, Idos, Gregory, additional, Imyanitov, Evgeny N., additional, Ingles, Sue Ann, additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, James, Paul, additional, Jenkins, Mark A., additional, Johansson, Mattias, additional, Johansson, Mikael, additional, John, Esther M., additional, Joshi, Amit D., additional, Kaneva, Radka, additional, Karlan, Beth Y., additional, Kelemen, Linda E., additional, Kühl, Tabea, additional, Khaw, Kay-Tee, additional, Khusnutdinova, Elza, additional, Kibel, Adam S., additional, Kiemeney, Lambertus A., additional, Kim, Jeri, additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Kogevinas, Manolis, additional, Kote-Jarai, Zsofia, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Kupryjanczyk, Jolanta, additional, Lacko, Martin, additional, Lam, Stephan, additional, Lambrechts, Diether, additional, Landi, Maria Teresa, additional, Lazarus, Philip, additional, Le, Nhu D., additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lenz, Heinz-Josef, additional, Leslie, Goska, additional, Lessel, Davor, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Li, additional, Li, Christopher I., additional, Lindblom, Annika, additional, Lindor, Noralane M., additional, Liu, Geoffrey, additional, Loupakis, Fotios, additional, Lubiński, Jan, additional, Maehle, Lovise, additional, Maier, Christiane, additional, Mannermaa, Arto, additional, Marchand, Loic Le, additional, Margolin, Sara, additional, May, Taymaa, additional, McGuffog, Lesley, additional, Meindl, Alfons, additional, Middha, Pooja, additional, Miller, Austin, additional, Milne, Roger L., additional, MacInnis, Robert J., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moreno, Victor, additional, Moysich, Kirsten B., additional, Mucci, Lorelei, additional, Muir, Kenneth, additional, Mulligan, Anna Marie, additional, Nathanson, Katherine L., additional, Neal, David E., additional, Ness, Andrew R., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Newcomb, Polly A., additional, Newcomb, Lisa F., additional, Nielsen, Finn Cilius, additional, Nikitina-Zake, Liene, additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Offit, Kenneth, additional, Olah, Edith, additional, Olama, Ali Amin Al, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Olsson, Håkan, additional, Osorio, Ana, additional, Pandha, Hardev, additional, Park, Jong Y., additional, Pashayan, Nora, additional, Parsons, Michael T., additional, Pejovic, Tanja, additional, Penney, Kathryn L., additional, Peters, Wilbert H M., additional, Phelan, Catherine M., additional, Phipps, Amanda I., additional, Plaseska-Karanfilska, Dijana, additional, Pring, Miranda, additional, Prokofyeva, Darya, additional, Radice, Paolo, additional, Stefansson, Kari, additional, Ramus, Susan J., additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, van Rensburg, Elizabeth J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Risch, Angela, additional, Roobol, Monique J., additional, Rosenstein, Barry S., additional, Rossing, Mary Anne, additional, De Ruyck, Kim, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schabath, Matthew B., additional, Schleutker, Johanna, additional, Schmidt, Marjanka K., additional, Setiawan, V. Wendy, additional, Shen, Hongbing, additional, Siegel, Erin M., additional, Sieh, Weiva, additional, Singer, Christian F., additional, Slattery, Martha L., additional, Sorensen, Karina Dalsgaard, additional, Southey, Melissa C., additional, Spurdle, Amanda B., additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stintzing, Sebastian, additional, Stone, Jennifer, additional, Sundfeldt, Karin, additional, Sutphen, Rebecca, additional, Swerdlow, Anthony J., additional, Tajara, Eloiza H., additional, Tangen, Catherine M., additional, Tardon, Adonina, additional, Taylor, Jack A., additional, Teare, M. Dawn, additional, Teixeira, Manuel R., additional, Terry, Mary Beth, additional, Terry, Kathryn L., additional, Thibodeau, Stephen N., additional, Thomassen, Mads, additional, Bjørge, Line, additional, Tischkowitz, Marc, additional, Toland, Amanda E., additional, Torres, Diana, additional, Townsend, Paul A., additional, Travis, Ruth C., additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Ulrich, Cornelia M., additional, Usmani, Nawaid, additional, Vachon, Celine M., additional, Van Nieuwenhuysen, Els, additional, Vega, Ana, additional, Aguado-Barrera, Miguel Elías, additional, Wang, Qin, additional, Webb, Penelope M., additional, Weinberg, Clarice R., additional, Weinstein, Stephanie, additional, Weissler, Mark C., additional, Weitzel, Jeffrey N., additional, West, Catharine M. L., additional, White, Emily, additional, Whittemore, Alice S., additional, Wichmann, H-Erich, additional, Wiklund, Fredrik, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Woll, Penella, additional, Woods, Michael, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yannoukakos, Drakoulis, additional, Zheng, Wei, additional, Zienolddiny, Shanbeh, additional, Ziogas, Argyrios, additional, Zorn, Kristin K., additional, Lane, Jacqueline M., additional, Saxena, Richa, additional, Thomas, Duncan, additional, Hung, Rayjean J., additional, Diergaarde, Brenda, additional, McKay, James, additional, Peters, Ulrike, additional, Hsu, Li, additional, García-Closas, Montserrat, additional, Eeles, Rosalind A., additional, Chenevix-Trench, Georgia, additional, Brennan, Paul J., additional, Haiman, Christopher A., additional, Simard, Jacques, additional, Easton, Douglas F., additional, Gruber, Stephen B., additional, Pharoah, Paul D. P., additional, Price, Alkes L., additional, Pasaniuc, Bogdan, additional, Amos, Christopher I., additional, Kraft, Peter, additional, and Lindström, Sara, additional

Published
2019
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5. Identification of nine new susceptibility loci for endometrial cancer

Author

O’Mara, Tracy A., primary, Glubb, Dylan M., additional, Amant, Frederic, additional, Annibali, Daniela, additional, Ashton, Katie, additional, Attia, John, additional, Auer, Paul L., additional, Beckmann, Matthias W., additional, Black, Amanda, additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brinton, Louise, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Chen, Maxine M., additional, Cheng, Timothy H. T., additional, Clarke, Christine L., additional, Clendenning, Mark, additional, Cook, Linda S., additional, Couch, Fergus J., additional, Cox, Angela, additional, Crous-Bous, Marta, additional, Czene, Kamila, additional, Day, Felix, additional, Dennis, Joe, additional, Depreeuw, Jeroen, additional, Doherty, Jennifer Anne, additional, Dörk, Thilo, additional, Dowdy, Sean C., additional, Dürst, Matthias, additional, Ekici, Arif B., additional, Fasching, Peter A., additional, Fridley, Brooke L., additional, Friedenreich, Christine M., additional, Fritschi, Lin, additional, Fung, Jenny, additional, García-Closas, Montserrat, additional, Gaudet, Mia M., additional, Giles, Graham G., additional, Goode, Ellen L., additional, Gorman, Maggie, additional, Haiman, Christopher A., additional, Hall, Per, additional, Hankison, Susan E., additional, Healey, Catherine S., additional, Hein, Alexander, additional, Hillemanns, Peter, additional, Hodgson, Shirley, additional, Hoivik, Erling A., additional, Holliday, Elizabeth G., additional, Hopper, John L., additional, Hunter, David J., additional, Jones, Angela, additional, Krakstad, Camilla, additional, Kristensen, Vessela N., additional, Lambrechts, Diether, additional, Marchand, Loic Le, additional, Liang, Xiaolin, additional, Lindblom, Annika, additional, Lissowska, Jolanta, additional, Long, Jirong, additional, Lu, Lingeng, additional, Magliocco, Anthony M., additional, Martin, Lynn, additional, McEvoy, Mark, additional, Meindl, Alfons, additional, Michailidou, Kyriaki, additional, Milne, Roger L., additional, Mints, Miriam, additional, Montgomery, Grant W., additional, Nassir, Rami, additional, Olsson, Håkan, additional, Orlow, Irene, additional, Otton, Geoffrey, additional, Palles, Claire, additional, Perry, John R. B., additional, Peto, Julian, additional, Pooler, Loreall, additional, Prescott, Jennifer, additional, Proietto, Tony, additional, Rebbeck, Timothy R., additional, Risch, Harvey A., additional, Rogers, Peter A. W., additional, Rübner, Matthias, additional, Runnebaum, Ingo, additional, Sacerdote, Carlotta, additional, Sarto, Gloria E., additional, Schumacher, Fredrick, additional, Scott, Rodney J., additional, Setiawan, V. Wendy, additional, Shah, Mitul, additional, Sheng, Xin, additional, Shu, Xiao-Ou, additional, Southey, Melissa C., additional, Swerdlow, Anthony J., additional, Tham, Emma, additional, Trovik, Jone, additional, Turman, Constance, additional, Tyrer, Jonathan P., additional, Vachon, Celine, additional, VanDen Berg, David, additional, Vanderstichele, Adriaan, additional, Wang, Zhaoming, additional, Webb, Penelope M., additional, Wentzensen, Nicolas, additional, Werner, Henrica M. J., additional, Winham, Stacey J., additional, Wolk, Alicja, additional, Xia, Lucy, additional, Xiang, Yong-Bing, additional, Yang, Hannah P., additional, Yu, Herbert, additional, Zheng, Wei, additional, Pharoah, Paul D. P., additional, Dunning, Alison M., additional, Kraft, Peter, additional, De Vivo, Immaculata, additional, Tomlinson, Ian, additional, Easton, Douglas F., additional, Spurdle, Amanda B., additional, and Thompson, Deborah J., additional

Published
2018
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6. Meta-analysis of genome-wide association studies identifies common susceptibility polymorphisms for colorectal and endometrial cancer near SH2B3 and TSHZ1

Author

Cheng, Timothy HT, primary, Thompson, Deborah, additional, Painter, Jodie, additional, O’Mara, Tracy, additional, Gorman, Maggie, additional, Martin, Lynn, additional, Palles, Claire, additional, Jones, Angela, additional, Buchanan, Daniel D., additional, Win, Aung Ko, additional, Hopper, John, additional, Jenkins, Mark, additional, Lindor, Noralane M., additional, Newcomb, Polly A., additional, Gallinger, Steve, additional, Conti, David, additional, Schumacher, Fred, additional, Casey, Graham, additional, Giles, Graham G, additional, Pharoah, Paul, additional, Peto, Julian, additional, Cox, Angela, additional, Swerdlow, Anthony, additional, Couch, Fergus, additional, Cunningham, Julie M, additional, Goode, Ellen L, additional, Winham, Stacey J, additional, Lambrechts, Diether, additional, Fasching, Peter, additional, Burwinkel, Barbara, additional, Brenner, Hermann, additional, Brauch, Hiltrud, additional, Chang-Claude, Jenny, additional, Salvesen, Helga B., additional, Kristensen, Vessela, additional, Darabi, Hatef, additional, Li, Jingmei, additional, Liu, Tao, additional, Lindblom, Annika, additional, Hall, Per, additional, de Polanco, Magdalena Echeverry, additional, Sans, Monica, additional, Carracedo, Angel, additional, Castellvi-Bel, Sergi, additional, Rojas-Martinez, Augusto, additional, Aguiar Jnr, Samuel, additional, Teixeira, Manuel R., additional, Dunning, Alison M, additional, Dennis, Joe, additional, Otton, Geoffrey, additional, Proietto, Tony, additional, Holliday, Elizabeth, additional, Attia, John, additional, Ashton, Katie, additional, Scott, Rodney J, additional, McEvoy, Mark, additional, Dowdy, Sean C, additional, Fridley, Brooke L, additional, Werner, Henrica MJ, additional, Trovik, Jone, additional, Njolstad, Tormund S, additional, Tham, Emma, additional, Mints, Miriam, additional, Runnebaum, Ingo, additional, Hillemanns, Peter, additional, Dörk, Thilo, additional, Amant, Frederic, additional, Schrauwen, Stefanie, additional, Hein, Alexander, additional, Beckmann, Matthias W, additional, Ekici, Arif, additional, Czene, Kamila, additional, Meindl, Alfons, additional, Bolla, Manjeet K, additional, Michailidou, Kyriaki, additional, Tyrer, Jonathan P, additional, Wang, Qin, additional, Ahmed, Shahana, additional, Healey, Catherine S, additional, Shah, Mitul, additional, Annibali, Daniela, additional, Depreeuw, Jeroen, additional, Al-Tassan, Nada A., additional, Harris, Rebecca, additional, Meyer, Brian F., additional, Whiffin, Nicola, additional, Hosking, Fay J, additional, Kinnersley, Ben, additional, Farrington, Susan M., additional, Timofeeva, Maria, additional, Tenesa, Albert, additional, Campbell, Harry, additional, Haile, Robert W., additional, Hodgson, Shirley, additional, Carvajal-Carmona, Luis, additional, Cheadle, Jeremy P., additional, Easton, Douglas, additional, Dunlop, Malcolm, additional, Houlston, Richard, additional, Spurdle, Amanda, additional, and Tomlinson, Ian, additional

Published
2015
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8. Hundreds of variants clustered in genomic loci and biological pathways affect human height

Author

Lango Allen, Hana, primary, Estrada, Karol, additional, Lettre, Guillaume, additional, Berndt, Sonja I., additional, Weedon, Michael N., additional, Rivadeneira, Fernando, additional, Willer, Cristen J., additional, Jackson, Anne U., additional, Vedantam, Sailaja, additional, Raychaudhuri, Soumya, additional, Ferreira, Teresa, additional, Wood, Andrew R., additional, Weyant, Robert J., additional, Segrè, Ayellet V., additional, Speliotes, Elizabeth K., additional, Wheeler, Eleanor, additional, Soranzo, Nicole, additional, Park, Ju-Hyun, additional, Yang, Jian, additional, Gudbjartsson, Daniel, additional, Heard-Costa, Nancy L., additional, Randall, Joshua C., additional, Qi, Lu, additional, Vernon Smith, Albert, additional, Mägi, Reedik, additional, Pastinen, Tomi, additional, Liang, Liming, additional, Heid, Iris M., additional, Luan, Jian’an, additional, Thorleifsson, Gudmar, additional, Winkler, Thomas W., additional, Goddard, Michael E., additional, Sin Lo, Ken, additional, Palmer, Cameron, additional, Workalemahu, Tsegaselassie, additional, Aulchenko, Yurii S., additional, Johansson, Åsa, additional, Carola Zillikens, M., additional, Feitosa, Mary F., additional, Esko, Tõnu, additional, Johnson, Toby, additional, Ketkar, Shamika, additional, Kraft, Peter, additional, Mangino, Massimo, additional, Prokopenko, Inga, additional, Absher, Devin, additional, Albrecht, Eva, additional, Ernst, Florian, additional, Glazer, Nicole L., additional, Hayward, Caroline, additional, Hottenga, Jouke-Jan, additional, Jacobs, Kevin B., additional, Knowles, Joshua W., additional, Kutalik, Zoltán, additional, Monda, Keri L., additional, Polasek, Ozren, additional, Preuss, Michael, additional, Rayner, Nigel W., additional, Robertson, Neil R., additional, Steinthorsdottir, Valgerdur, additional, Tyrer, Jonathan P., additional, Voight, Benjamin F., additional, Wiklund, Fredrik, additional, Xu, Jianfeng, additional, Hua Zhao, Jing, additional, Nyholt, Dale R., additional, Pellikka, Niina, additional, Perola, Markus, additional, Perry, John R. B., additional, Surakka, Ida, additional, Tammesoo, Mari-Liis, additional, Altmaier, Elizabeth L., additional, Amin, Najaf, additional, Aspelund, Thor, additional, Bhangale, Tushar, additional, Boucher, Gabrielle, additional, Chasman, Daniel I., additional, Chen, Constance, additional, Coin, Lachlan, additional, Cooper, Matthew N., additional, Dixon, Anna L., additional, Gibson, Quince, additional, Grundberg, Elin, additional, Hao, Ke, additional, Juhani Junttila, M., additional, Kaplan, Lee M., additional, Kettunen, Johannes, additional, König, Inke R., additional, Kwan, Tony, additional, Lawrence, Robert W., additional, Levinson, Douglas F., additional, Lorentzon, Mattias, additional, McKnight, Barbara, additional, Morris, Andrew P., additional, Müller, Martina, additional, Suh Ngwa, Julius, additional, Purcell, Shaun, additional, Rafelt, Suzanne, additional, Salem, Rany M., additional, Salvi, Erika, additional, Sanna, Serena, additional, Shi, Jianxin, additional, Sovio, Ulla, additional, Thompson, John R., additional, Turchin, Michael C., additional, Vandenput, Liesbeth, additional, Verlaan, Dominique J., additional, Vitart, Veronique, additional, White, Charles C., additional, Ziegler, Andreas, additional, Almgren, Peter, additional, Balmforth, Anthony J., additional, Campbell, Harry, additional, Citterio, Lorena, additional, De Grandi, Alessandro, additional, Dominiczak, Anna, additional, Duan, Jubao, additional, Elliott, Paul, additional, Elosua, Roberto, additional, Eriksson, Johan G., additional, Freimer, Nelson B., additional, Geus, Eco J. C., additional, Glorioso, Nicola, additional, Haiqing, Shen, additional, Hartikainen, Anna-Liisa, additional, Havulinna, Aki S., additional, Hicks, Andrew A., additional, Hui, Jennie, additional, Igl, Wilmar, additional, Illig, Thomas, additional, Jula, Antti, additional, Kajantie, Eero, additional, Kilpeläinen, Tuomas O., additional, Koiranen, Markku, additional, Kolcic, Ivana, additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Laitinen, Jaana, additional, Liu, Jianjun, additional, Lokki, Marja-Liisa, additional, Marusic, Ana, additional, Maschio, Andrea, additional, Meitinger, Thomas, additional, Mulas, Antonella, additional, Paré, Guillaume, additional, Parker, Alex N., additional, Peden, John F., additional, Petersmann, Astrid, additional, Pichler, Irene, additional, Pietiläinen, Kirsi H., additional, Pouta, Anneli, additional, Ridderstråle, Martin, additional, Rotter, Jerome I., additional, Sambrook, Jennifer G., additional, Sanders, Alan R., additional, Oliver Schmidt, Carsten, additional, Sinisalo, Juha, additional, Smit, Jan H., additional, Stringham, Heather M., additional, Bragi Walters, G., additional, Widen, Elisabeth, additional, Wild, Sarah H., additional, Willemsen, Gonneke, additional, Zagato, Laura, additional, Zgaga, Lina, additional, Zitting, Paavo, additional, Alavere, Helene, additional, Farrall, Martin, additional, McArdle, Wendy L., additional, Nelis, Mari, additional, Peters, Marjolein J., additional, Ripatti, Samuli, additional, van Meurs, Joyce B. J., additional, Aben, Katja K., additional, Ardlie, Kristin G., additional, Beckmann, Jacques S., additional, Beilby, John P., additional, Bergman, Richard N., additional, Bergmann, Sven, additional, Collins, Francis S., additional, Cusi, Daniele, additional, den Heijer, Martin, additional, Eiriksdottir, Gudny, additional, Gejman, Pablo V., additional, Hall, Alistair S., additional, Hamsten, Anders, additional, Huikuri, Heikki V., additional, Iribarren, Carlos, additional, Kähönen, Mika, additional, Kaprio, Jaakko, additional, Kathiresan, Sekar, additional, Kiemeney, Lambertus, additional, Kocher, Thomas, additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, Melander, Olle, additional, Mosley Jr, Tom H., additional, Musk, Arthur W., additional, Nieminen, Markku S., additional, O’Donnell, Christopher J., additional, Ohlsson, Claes, additional, Oostra, Ben, additional, Palmer, Lyle J., additional, Raitakari, Olli, additional, Ridker, Paul M., additional, Rioux, John D., additional, Rissanen, Aila, additional, Rivolta, Carlo, additional, Schunkert, Heribert, additional, Shuldiner, Alan R., additional, Siscovick, David S., additional, Stumvoll, Michael, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, van Ommen, Gert-Jan, additional, Viikari, Jorma, additional, Heath, Andrew C., additional, Martin, Nicholas G., additional, Montgomery, Grant W., additional, Province, Michael A., additional, Kayser, Manfred, additional, Arnold, Alice M., additional, Atwood, Larry D., additional, Boerwinkle, Eric, additional, Chanock, Stephen J., additional, Deloukas, Panos, additional, Gieger, Christian, additional, Grönberg, Henrik, additional, Hall, Per, additional, Hattersley, Andrew T., additional, Hengstenberg, Christian, additional, Hoffman, Wolfgang, additional, Mark Lathrop, G., additional, Salomaa, Veikko, additional, Schreiber, Stefan, additional, Uda, Manuela, additional, Waterworth, Dawn, additional, Wright, Alan F., additional, Assimes, Themistocles L., additional, Barroso, Inês, additional, Hofman, Albert, additional, Mohlke, Karen L., additional, Boomsma, Dorret I., additional, Caulfield, Mark J., additional, Adrienne Cupples, L., additional, Erdmann, Jeanette, additional, Fox, Caroline S., additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Harris, Tamara B., additional, Hayes, Richard B., additional, Jarvelin, Marjo-Riitta, additional, Mooser, Vincent, additional, Munroe, Patricia B., additional, Ouwehand, Willem H., additional, Penninx, Brenda W., additional, Pramstaller, Peter P., additional, Quertermous, Thomas, additional, Rudan, Igor, additional, Samani, Nilesh J., additional, Spector, Timothy D., additional, Völzke, Henry, additional, Watkins, Hugh, additional, Wilson, James F., additional, Groop, Leif C., additional, Haritunians, Talin, additional, Hu, Frank B., additional, Kaplan, Robert C., additional, Metspalu, Andres, additional, North, Kari E., additional, Schlessinger, David, additional, Wareham, Nicholas J., additional, Hunter, David J., additional, O’Connell, Jeffrey R., additional, Strachan, David P., additional, Wichmann, H.-Erich, additional, Borecki, Ingrid B., additional, van Duijn, Cornelia M., additional, Schadt, Eric E., additional, Thorsteinsdottir, Unnur, additional, Peltonen, Leena, additional, Uitterlinden, André G., additional, Visscher, Peter M., additional, Chatterjee, Nilanjan, additional, Loos, Ruth J. F., additional, Boehnke, Michael, additional, McCarthy, Mark I., additional, Ingelsson, Erik, additional, Lindgren, Cecilia M., additional, Abecasis, Gonçalo R., additional, Stefansson, Kari, additional, Frayling, Timothy M., additional, and Hirschhorn, Joel N., additional

Published
2010
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9. Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Author

Fachal, Laura, Aschard, Hugues, Beesley, Jonathan, Barnes, Daniel R, Allen, Jamie, Kar, Siddhartha, Pooley, Karen A, Dennis, Joe, Michailidou, Kyriaki, Turman, Constance, Soucy, Penny, Lemaçon, Audrey, Lush, Michael, Tyrer, Jonathan P, Ghoussaini, Maya, Moradi Marjaneh, Mahdi, Jiang, Xia, Agata, Simona, Aittomäki, Kristiina, Alonso, M Rosario, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arason, Adalgeir, Arndt, Volker, Aronson, Kristan J, Arun, Banu K, Auber, Bernd, Auer, Paul L, Azzollini, Jacopo, Balmaña, Judith, Barkardottir, Rosa B, Barrowdale, Daniel, Beeghly-Fadiel, Alicia, Benitez, Javier, Bermisheva, Marina, Białkowska, Katarzyna, Blanco, Amie M, Blomqvist, Carl, Blot, William, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Bonanni, Bernardo, Borg, Ake, Bosse, Kristin, Brauch, Hiltrud, Brenner, Hermann, Briceno, Ignacio, Brock, Ian W, Brooks-Wilson, Angela, Brüning, Thomas, Burwinkel, Barbara, Buys, Saundra S, Cai, Qiuyin, Caldés, Trinidad, Caligo, Maria A, Camp, Nicola J, Campbell, Ian, Canzian, Federico, Carroll, Jason S, Carter, Brian D, Castelao, Jose E, Chiquette, Jocelyne, Christiansen, Hans, Chung, Wendy K, Claes, Kathleen BM, Clarke, Christine L, GEMO Study Collaborators, EMBRACE Collaborators, Collée, J Margriet, Cornelissen, Sten, Couch, Fergus J, Cox, Angela, Cross, Simon S, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, De La Hoya, Miguel, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Dite, Gillian S, Domchek, Susan M, Dörk, Thilo, Dos-Santos-Silva, Isabel, Droit, Arnaud, Dubois, Stéphane, Dumont, Martine, Duran, Mercedes, Durcan, Lorraine, Dwek, Miriam, Eccles, Diana M, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Floris, Giuseppe, Flyger, Henrik, Foretova, Lenka, Foulkes, William D, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gabrielson, Marike, Gago-Dominguez, Manuela, Gambino, Gaetana, Ganz, Patricia A, Gapstur, Susan M, Garber, Judy, García-Sáenz, José A, Gaudet, Mia M, Georgoulias, Vassilios, Giles, Graham G, Glendon, Gord, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Tibiletti, Maria Grazia, Greene, Mark H, Grip, Mervi, Gronwald, Jacek, Grundy, Anne, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia A, Hartikainen, Jaana M, Hartman, Mikael, He, Wei, Healey, Catherine S, Heemskerk-Gerritsen, Bernadette AM, Heyworth, Jane, Hillemanns, Peter, Hogervorst, Frans BL, Hollestelle, Antoinette, Hooning, Maartje J, Hopper, John L, Howell, Anthony, Huang, Guanmengqian, Hulick, Peter J, Imyanitov, Evgeny N, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Isaacs, Claudine, Iwasaki, Motoki, Jager, Agnes, Jakimovska, Milena, Jakubowska, Anna, James, Paul A, Janavicius, Ramunas, Jankowitz, Rachel C, John, Esther M, Johnson, Nichola, Jones, Michael E, Jukkola-Vuorinen, Arja, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Kapoor, Pooja Middha, Karlan, Beth Y, Keeman, Renske, Kerin, Michael J, Khusnutdinova, Elza, Kiiski, Johanna I, Kirk, Judy, Kitahara, Cari M, Ko, Yon-Dschun, Konstantopoulou, Irene, Kosma, Veli-Matti, Koutros, Stella, Kubelka-Sabit, Katerina, Kwong, Ava, Kyriacou, Kyriacos, Laitman, Yael, Lambrechts, Diether, Lee, Eunjung, Leslie, Goska, Lester, Jenny, Lesueur, Fabienne, Lindblom, Annika, Lo, Wing-Yee, Long, Jirong, Lophatananon, Artitaya, Loud, Jennifer T, Lubiński, Jan, MacInnis, Robert J, Maishman, Tom, Makalic, Enes, Mannermaa, Arto, Manoochehri, Mehdi, Manoukian, Siranoush, Margolin, Sara, Martinez, Maria Elena, Matsuo, Keitaro, Maurer, Tabea, Mavroudis, Dimitrios, Mayes, Rebecca, McGuffog, Lesley, McLean, Catriona, Mebirouk, Noura, Meindl, Alfons, Miller, Austin, Miller, Nicola, Montagna, Marco, Moreno, Fernando, Muir, Kenneth, Mulligan, Anna Marie, Muñoz-Garzon, Victor M, Muranen, Taru A, Narod, Steven A, Nassir, Rami, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Neven, Patrick, Nielsen, Finn C, Nikitina-Zake, Liene, Norman, Aaron, Offit, Kenneth, Olah, Edith, Olopade, Olufunmilayo I, Olsson, Håkan, Orr, Nick, Osorio, Ana, Pankratz, V Shane, Papp, Janos, Park, Sue K, Park-Simon, Tjoung-Won, Parsons, Michael T, Paul, James, Pedersen, Inge Sokilde, Peissel, Bernard, Peshkin, Beth, Peterlongo, Paolo, Peto, Julian, Plaseska-Karanfilska, Dijana, Prajzendanc, Karolina, Prentice, Ross, Presneau, Nadege, Prokofyeva, Darya, Pujana, Miquel Angel, Pylkäs, Katri, Radice, Paolo, Ramus, Susan J, Rantala, Johanna, Rau-Murthy, Rohini, Rennert, Gad, Risch, Harvey A, Robson, Mark, Romero, Atocha, Rossing, Maria, Saloustros, Emmanouil, Sánchez-Herrero, Estela, Sandler, Dale P, Santamariña, Marta, Saunders, Christobel, Sawyer, Elinor J, Scheuner, Maren T, Schmidt, Daniel F, Schmutzler, Rita K, Schneeweiss, Andreas, Schoemaker, Minouk J, Schöttker, Ben, Schürmann, Peter, Scott, Christopher, Scott, Rodney J, Senter, Leigha, Seynaeve, Caroline M, Shah, Mitul, Sharma, Priyanka, Shen, Chen-Yang, Shu, Xiao-Ou, Singer, Christian F, Slavin, Thomas P, Smichkoska, Snezhana, Southey, Melissa C, Spinelli, John J, Spurdle, Amanda B, Stone, Jennifer, Stoppa-Lyonnet, Dominique, Sutter, Christian, Swerdlow, Anthony J, Tamimi, Rulla M, Tan, Yen Yen, Tapper, William J, Taylor, Jack A, Teixeira, Manuel R, Tengström, Maria, Teo, Soo Hwang, Terry, Mary Beth, Teulé, Alex, Thomassen, Mads, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Tollenaar, Rob AEM, Tomlinson, Ian, Torres, Diana, Torres-Mejía, Gabriela, Troester, Melissa A, Truong, Thérèse, Tung, Nadine, Tzardi, Maria, Ulmer, Hans-Ulrich, Vachon, Celine M, Van Asperen, Christi J, Van Der Kolk, Lizet E, Van Rensburg, Elizabeth J, Vega, Ana, Viel, Alessandra, Vijai, Joseph, Vogel, Maartje J, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R, Weitzel, Jeffrey N, Wendt, Camilla, Wildiers, Hans, Winqvist, Robert, Wolk, Alicja, Wu, Anna H, Yannoukakos, Drakoulis, Zhang, Yan, Zheng, Wei, Hunter, David, Pharoah, Paul DP, Chang-Claude, Jenny, García-Closas, Montserrat, Schmidt, Marjanka K, Milne, Roger L, Kristensen, Vessela N, French, Juliet D, Edwards, Stacey L, Antoniou, Antonis C, Chenevix-Trench, Georgia, Simard, Jacques, Easton, Douglas F, Kraft, Peter, and Dunning, Alison M

Subjects
Quantitative Trait Loci, Chromosome Mapping, Bayes Theorem, Breast Neoplasms, Regulatory Sequences, Nucleic Acid, Polymorphism, Single Nucleotide, Linkage Disequilibrium, 3. Good health, Risk Factors, Biomarkers, Tumor, Humans, Female, Genetic Predisposition to Disease, Genome-Wide Association Study
Abstract

Genome-wide association studies have identified breast cancer risk variants in over 150 genomic regions, but the mechanisms underlying risk remain largely unknown. These regions were explored by combining association analysis with in silico genomic feature annotations. We defined 205 independent risk-associated signals with the set of credible causal variants in each one. In parallel, we used a Bayesian approach (PAINTOR) that combines genetic association, linkage disequilibrium and enriched genomic features to determine variants with high posterior probabilities of being causal. Potentially causal variants were significantly over-represented in active gene regulatory regions and transcription factor binding sites. We applied our INQUSIT pipeline for prioritizing genes as targets of those potentially causal variants, using gene expression (expression quantitative trait loci), chromatin interaction and functional annotations. Known cancer drivers, transcription factors and genes in the developmental, apoptosis, immune system and DNA integrity checkpoint gene ontology pathways were over-represented among the highest-confidence target genes.

10. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C, Nagle, Christina M, Thrift, Aaron P, Pharoah, Paul DP, Ewing, Ailith, Pearce, Celeste Leigh, Zheng, Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Chang-Claude, Jenny, Jung, Audrey Y, Moysich, Kirsten B, Odunsi, Kunle, Goodman, Marc T, Wilkens, Lynne R, Thompson, Pamela J, Shvetsov, Yurii B, Dörk, Thilo, Park-Simon, Tjoung-Won, Hillemanns, Peter, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M, Leminen, Arto, Modugno, Francesmary, Ness, Roberta B, Edwards, Robert P, Kelley, Joseph L, Heitz, Florian, Du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Karlan, Beth Y, Lester, Jenny, Orsulic, Sandra, Rimel, Bobbie J, Kjær, Susanne K, Høgdall, Estrid, Jensen, Allan, Goode, Ellen L, Fridley, Brooke L, Cunningham, Julie M, Winham, Stacey J, Giles, Graham G, Bruinsma, Fiona, Milne, Roger L, Southey, Melissa C, Hildebrandt, Michelle AT, Wu, Xifeng, Lu, Karen H, Liang, Dong, Levine, Douglas A, Bisogna, Maria, Schildkraut, Joellen M, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Bandera, Elisa V, Olson, Sara H, Salvesen, Helga B, Thomsen, Liv Cecilie Vestrheim, Kopperud, Reidun K, Bjorge, Line, Kiemeney, Lambertus A, Massuger, Leon FAG, Pejovic, Tanja, Bruegl, Amanda, Cook, Linda S, Le, Nhu D, Swenerton, Kenneth D, Brooks-Wilson, Angela, Kelemen, Linda E, Lubiński, Jan, Huzarski, Tomasz, Gronwald, Jacek, Menkiszak, Janusz, Wentzensen, Nicolas, Brinton, Louise, Yang, Hannah, Lissowska, Jolanta, Høgdall, Claus K, Lundvall, Lene, Song, Honglin, Tyrer, Jonathan P, Campbell, Ian, Eccles, Diana, Paul, James, Glasspool, Rosalind, Siddiqui, Nadeem, Whittemore, Alice S, Sieh, Weiva, McGuire, Valerie, Rothstein, Joseph H, Narod, Steven A, Phelan, Catherine, Risch, Harvey A, McLaughlin, John R, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Wu, Anna H, Pike, Malcolm C, Tseng, Chiu-Chen, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Budzilowska, Agnieszka, Rzepecka, Iwona K, Webb, Penelope M, and Ovarian Cancer Association Consortium

Subjects
Adult, Aged, 80 and over, Ovarian Neoplasms, Adolescent, Geography, Carcinoma, Ovarian Epithelial, Mendelian Randomization Analysis, Middle Aged, Body Height, 3. Good health, Young Adult, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Aged
Abstract

BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

11. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Author

Ho, Weang-Kee, Tan, Min-Min, Mavaddat, Nasim, Tai, Mei-Chee, Mariapun, Shivaani, Li, Jingmei, Ho, Peh-Joo, Dennis, Joe, Tyrer, Jonathan P, Bolla, Manjeet K, Michailidou, Kyriaki, Wang, Qin, Kang, Daehee, Choi, Ji-Yeob, Jamaris, Suniza, Shu, Xiao-Ou, Yoon, Sook-Yee, Park, Sue K, Kim, Sung-Won, Shen, Chen-Yang, Yu, Jyh-Cherng, Tan, Ern Yu, Chan, Patrick Mun Yew, Muir, Kenneth, Lophatananon, Artitaya, Wu, Anna H, Stram, Daniel O, Matsuo, Keitaro, Ito, Hidemi, Chan, Ching Wan, Ngeow, Joanne, Yong, Wei Sean, Lim, Swee Ho, Lim, Geok Hoon, Kwong, Ava, Chan, Tsun L, Tan, Su Ming, Seah, Jaime, John, Esther M, Kurian, Allison W, Koh, Woon-Puay, Khor, Chiea Chuen, Iwasaki, Motoki, Yamaji, Taiki, Tan, Kiak Mien Veronique, Tan, Kiat Tee Benita, Spinelli, John J, Aronson, Kristan J, Hasan, Siti Norhidayu, Rahmat, Kartini, Vijayananthan, Anushya, Sim, Xueling, Pharoah, Paul DP, Zheng, Wei, Dunning, Alison M, Simard, Jacques, Van Dam, Rob Martinus, Yip, Cheng-Har, Taib, Nur Aishah Mohd, Hartman, Mikael, Easton, Douglas F, Teo, Soo-Hwang, and Antoniou, Antonis C

Subjects
Adult, Risk, Multifactorial Inheritance, Asia, Breast Neoplasms, Middle Aged, Prognosis, Polymorphism, Single Nucleotide, 3. Good health, Europe, Case-Control Studies, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Aged, Genome-Wide Association Study
Abstract

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

12. A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Author

Coignard, Juliette, Lush, Michael, Beesley, Jonathan, O'Mara, Tracy A, Dennis, Joe, Tyrer, Jonathan P, Barnes, Daniel R, McGuffog, Lesley, Leslie, Goska, Bolla, Manjeet K, Adank, Muriel A, Agata, Simona, Ahearn, Thomas, Aittomäki, Kristiina, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Arnold, Norbert, Aronson, Kristan J, Arun, Banu K, Augustinsson, Annelie, Azzollini, Jacopo, Barrowdale, Daniel, Baynes, Caroline, Becher, Heiko, Bermisheva, Marina, Bernstein, Leslie, Białkowska, Katarzyna, Blomqvist, Carl, Bojesen, Stig E, Bonanni, Bernardo, Borg, Ake, Brauch, Hiltrud, Brenner, Hermann, Burwinkel, Barbara, Buys, Saundra S, Caldés, Trinidad, Caligo, Maria A, Campa, Daniele, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chanock, Stephen J, Chung, Wendy K, Claes, Kathleen BM, Clarke, Christine L, GEMO Study Collaborators, EMBRACE Collaborators, Collée, J Margriet, Conroy, Don M, Czene, Kamila, Daly, Mary B, Devilee, Peter, Diez, Orland, Ding, Yuan Chun, Domchek, Susan M, Dörk, Thilo, Dos-Santos-Silva, Isabel, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Eliassen, A Heather, Engel, Christoph, Eriksson, Mikael, Evans, D Gareth, Fasching, Peter A, Flyger, Henrik, Fostira, Florentia, Friedman, Eitan, Fritschi, Lin, Frost, Debra, Gago-Dominguez, Manuela, Gapstur, Susan M, Garber, Judy, Garcia-Barberan, Vanesa, García-Closas, Montserrat, García-Sáenz, José A, Gaudet, Mia M, Gayther, Simon A, Gehrig, Andrea, Georgoulias, Vassilios, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Greene, Mark H, Guénel, Pascal, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hamann, Ute, Harrington, Patricia A, Hart, Steven N, He, Wei, Hogervorst, Frans BL, Hollestelle, Antoinette, Hopper, John L, Horcasitas, Darling J, Hulick, Peter J, Hunter, David J, Imyanitov, Evgeny N, KConFab Investigators, HEBON Investigators, ABCTB Investigators, Jager, Agnes, Jakubowska, Anna, James, Paul A, Jensen, Uffe Birk, John, Esther M, Jones, Michael E, Kaaks, Rudolf, Kapoor, Pooja Middha, Karlan, Beth Y, Keeman, Renske, Khusnutdinova, Elza, Kiiski, Johanna I, Ko, Yon-Dschun, Kosma, Veli-Matti, Kraft, Peter, Kurian, Allison W, Laitman, Yael, Lambrechts, Diether, Le Marchand, Loic, Lester, Jenny, Lesueur, Fabienne, Lindstrom, Tricia, Lopez-Fernández, Adria, Loud, Jennifer T, Luccarini, Craig, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Martens, John WM, Mebirouk, Noura, Meindl, Alfons, Miller, Austin, Milne, Roger L, Montagna, Marco, Nathanson, Katherine L, Neuhausen, Susan L, Nevanlinna, Heli, Nielsen, Finn C, O'Brien, Katie M, Olopade, Olufunmilayo I, Olson, Janet E, Olsson, Håkan, Osorio, Ana, Ottini, Laura, Park-Simon, Tjoung-Won, Parsons, Michael T, Pedersen, Inge Sokilde, Peshkin, Beth, Peterlongo, Paolo, Peto, Julian, Pharoah, Paul DP, Phillips, Kelly-Anne, Polley, Eric C, Poppe, Bruce, Presneau, Nadege, Pujana, Miquel Angel, Punie, Kevin, Radice, Paolo, Rantala, Johanna, Rashid, Muhammad U, Rennert, Gad, Rennert, Hedy S, Robson, Mark, Romero, Atocha, Rossing, Maria, Saloustros, Emmanouil, Sandler, Dale P, Santella, Regina, Scheuner, Maren T, Schmidt, Marjanka K, Schmidt, Gunnar, Scott, Christopher, Sharma, Priyanka, Soucy, Penny, Southey, Melissa C, Spinelli, John J, Steinsnyder, Zoe, Stone, Jennifer, Stoppa-Lyonnet, Dominique, Swerdlow, Anthony, Tamimi, Rulla M, Tapper, William J, Taylor, Jack A, Terry, Mary Beth, Teulé, Alex, Thull, Darcy L, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Trainer, Alison H, Truong, Thérèse, Tung, Nadine, Vachon, Celine M, Vega, Ana, Vijai, Joseph, Wang, Qin, Wappenschmidt, Barbara, Weinberg, Clarice R, Weitzel, Jeffrey N, Wendt, Camilla, Wolk, Alicja, Yadav, Siddhartha, Yang, Xiaohong R, Yannoukakos, Drakoulis, Zheng, Wei, Ziogas, Argyrios, Zorn, Kristin K, Park, Sue K, Thomassen, Mads, Offit, Kenneth, Schmutzler, Rita K, Couch, Fergus J, Simard, Jacques, Chenevix-Trench, Georgia, Easton, Douglas F, Andrieu, Nadine, and Antoniou, Antonis C

Subjects
Adult, BRCA2 Protein, endocrine system diseases, Genotype, BRCA1 Protein, Quantitative Trait Loci, Breast Neoplasms, Middle Aged, Polymorphism, Single Nucleotide, Linkage Disequilibrium, 3. Good health, Risk Factors, Mutation, Humans, Female, Genetic Predisposition to Disease, skin and connective tissue diseases, Alleles, Genome-Wide Association Study
Abstract

Breast cancer (BC) risk for BRCA1 and BRCA2 mutation carriers varies by genetic and familial factors. About 50 common variants have been shown to modify BC risk for mutation carriers. All but three, were identified in general population studies. Other mutation carrier-specific susceptibility variants may exist but studies of mutation carriers have so far been underpowered. We conduct a novel case-only genome-wide association study comparing genotype frequencies between 60,212 general population BC cases and 13,007 cases with BRCA1 or BRCA2 mutations. We identify robust novel associations for 2 variants with BC for BRCA1 and 3 for BRCA2 mutation carriers, P < 10-8, at 5 loci, which are not associated with risk in the general population. They include rs60882887 at 11p11.2 where MADD, SP11 and EIF1, genes previously implicated in BC biology, are predicted as potential targets. These findings will contribute towards customising BC polygenic risk scores for BRCA1 and BRCA2 mutation carriers.

13. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Author

Turcot, Valérie, Lu, Yingchang, Highland, Heather M, Schurmann, Claudia, Justice, Anne E, Fine, Rebecca S, Bradfield, Jonathan P, Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E, Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E, Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L, Alfred, Tamuno, Feitosa, Mary F, Masca, Nicholas GD, Manning, Alisa K, Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie CY, Reiner, Alex P, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Abecasis, Gonçalo, Aben, Katja K, Alam, Dewan S, Alharthi, Sameer E, Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W, Auer, Paul L, Balkau, Beverley, Bang, Lia E, Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bots, Michiel L, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H, Broer, Linda, Brumat, Marco, Burt, Amber A, Butterworth, Adam S, Campbell, Peter T, Cappellani, Stefania, Carey, David J, Catamo, Eulalia, Caulfield, Mark J, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der I, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Cocca, Massimiliano, Collins, Francis S, Cook, James P, Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J, Crosslin, David S, Cuellar-Partida, Gabriel, D'Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul IW, Groot, Mark CH, Mutsert, Renée, Deary, Ian J, Dedoussis, George, Demerath, Ellen W, Heijer, Martin, Hollander, Anneke I, Ruijter, Hester M, Dennis, Joe G, Denny, Josh C, Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Edwards, Todd L, Ellinghaus, David, Ellinor, Patrick T, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I Sadaf, Faul, Jessica D, Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Ford, Ian, Fornage, Myriam, Franco, Oscar H, Franke, Andre, Franks, Paul W, Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P, Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan FA, Grarup, Niels, Griffiths, Helen L, Grove, Megan L, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R, Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B, Hattersley, Andrew T, Have, Christian T, Hayward, Caroline, He, Liang, Heard-Costa, Nancy L, Heath, Andrew C, Heid, Iris M, Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Huang, Paul L, Huffman, Jennifer E, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jansson, Jan-Håkan, Jarvik, Gail P, Jensen, Gorm B, Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E, Jørgensen, Torben, Jukema, J Wouter, Kahali, Bratati, Kahn, René S, Kähönen, Mika, Kamstrup, Pia R, Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A, Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Ethan M, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Liu, Yongmei, Lo, Ken S, Lophatananon, Artitaya, Lotery, Andrew J, Loukola, Anu, Luan, Jian'an, Lubitz, Steven A, Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L, McCarthy, Mark I, McKean-Cowdin, Roberta, Medland, Sarah E, Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L, Moilanen, Leena, Moitry, Marie, Montgomery, Grant W, Mook-Kanamori, Dennis O, Moore, Carmel, Mori, Trevor A, Morris, Andrew D, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Nalls, Mike A, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Nielsen, Sune F, Nikus, Kjell, Njølstad, Pål R, Nordestgaard, Børge G, Nyholt, Dale R, O'Connel, Jeffrey R, O'Donoghue, Michelle L, Olde Loohuis, Loes M, Ophoff, Roel A, Owen, Katharine R, Packard, Chris J, Padmanabhan, Sandosh, Palmer, Colin NA, Palmer, Nicholette D, Pasterkamp, Gerard, Patel, Aniruddh P, Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Person, Thomas N, Peters, Annette, Petersen, Eva RB, Peyser, Patricia A, Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J, Puolijoki, Hannu, Raitakari, Olli T, Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F, Renström, Frida, Rheinberger, Myriam, Ridker, Paul M, Rioux, John D, Rivas, Manuel A, Roberts, David J, Robertson, Neil R, Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo P, Shah, Svati H, Sheu, Wayne H-H, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Albert V, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Starr, John M, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J, Tada, Hayato, Tansey, Katherine E, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P, Uher, Rudolf, Uitterlinden, André G, Uusitupa, Matti, Laan, Sander W, Duijn, Cornelia M, Leeuwen, Nienke, Van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V, Varma, Rohit, Velez Edwards, Digna R, Vermeulen, Sita H, Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wang, Yiqin, Ware, Erin B, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Witte, Daniel R, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, CHD Exome+ Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, EPIC InterAct Consortium, INTERVAL Study, ReproGen Consortium, T2D-Genes Consortium, MAGIC Investigators, Understanding Society Scientific Group, Rotter, Jerome I, Pospisilik, John A, Rivadeneira, Fernando, Borecki, Ingrid B, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, North, Kari E, Lindgren, Cecilia M, Hirschhorn, Joel N, and Loos, Ruth JF

Subjects
2. Zero hunger, Adult, Male, Genetic Variation, Proteins, Syndrome, Body Mass Index, Gene Frequency, Animals, Humans, Drosophila, Female, Obesity, Energy Intake, Energy Metabolism
Abstract

Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.

14. Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, DeFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, Ganz, Patricia A, Garber, Judy, García-Sáenz, José A, Gayther, Simon A, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Goode, Ellen L, Goodman, Marc T, Goodman, Gary, Grankvist, Kjell, Greene, Mark H, Gronberg, Henrik, Gronwald, Jacek, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C, Hamilton, Robert J, Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Høgdall, Estrid, Hong, Yun-Chul, Hopper, John L, Houlston, Richard, Hulick, Peter J, Hunter, David J, Huntsman, David G, Idos, Gregory, Imyanitov, Evgeny N, Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A, Johansson, Mattias, Johansson, Mikael, John, Esther M, Joshi, Amit D, Kaneva, Radka, Karlan, Beth Y, Kelemen, Linda E, Kühl, Tabea, Khaw, Kay-Tee, Khusnutdinova, Elza, Kibel, Adam S, Kiemeney, Lambertus A, Kim, Jeri, Kjaer, Susanne K, Knight, Julia A, Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N, Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D, Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz-Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A, Li, Li, Li, Christopher I, Lindblom, Annika, Lindor, Noralane M, Liu, Geoffrey, Loupakis, Fotios, Lubiński, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Marchand, Loic Le, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L, MacInnis, Robert J, Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B, Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L, Neal, David E, Ness, Andrew R, Neuhausen, Susan L, Nevanlinna, Heli, Newcomb, Polly A, Newcomb, Lisa F, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Børge G, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olama, Ali Amin Al, Olopade, Olufunmilayo I, Olshan, Andrew F, Olsson, Håkan, Osorio, Ana, Pandha, Hardev, Park, Jong Y, Pashayan, Nora, Parsons, Michael T, Pejovic, Tanja, Penney, Kathryn L, Peters, Wilbert HM, Phelan, Catherine M, Phipps, Amanda I, Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Van Rensburg, Elizabeth J, Riggan, Marjorie J, Risch, Harvey A, Risch, Angela, Roobol, Monique J, Rosenstein, Barry S, Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schabath, Matthew B, Schleutker, Johanna, Schmidt, Marjanka K, Setiawan, V Wendy, Shen, Hongbing, Siegel, Erin M, Sieh, Weiva, Singer, Christian F, Slattery, Martha L, Sorensen, Karina Dalsgaard, Southey, Melissa C, Spurdle, Amanda B, Stanford, Janet L, Stevens, Victoria L, Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J, Tajara, Eloiza H, Tangen, Catherine M, Tardon, Adonina, Taylor, Jack A, Teare, M Dawn, Teixeira, Manuel R, Terry, Mary Beth, Terry, Kathryn L, Thibodeau, Stephen N, Thomassen, Mads, Bjørge, Line, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Townsend, Paul A, Travis, Ruth C, Tung, Nadine, Tworoger, Shelley S, Ulrich, Cornelia M, Usmani, Nawaid, Vachon, Celine M, Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elías, Wang, Qin, Webb, Penelope M, Weinberg, Clarice R, Weinstein, Stephanie, Weissler, Mark C, Weitzel, Jeffrey N, West, Catharine ML, White, Emily, Whittemore, Alice S, Wichmann, H-Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H, Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K, Lane, Jacqueline M, Saxena, Richa, Thomas, Duncan, Hung, Rayjean J, Diergaarde, Brenda, McKay, James, Peters, Ulrike, Hsu, Li, García-Closas, Montserrat, Eeles, Rosalind A, Chenevix-Trench, Georgia, Brennan, Paul J, Haiman, Christopher A, Simard, Jacques, Easton, Douglas F, Gruber, Stephen B, Pharoah, Paul DP, Price, Alkes L, Pasaniuc, Bogdan, Amos, Christopher I, Kraft, Peter, and Lindström, Sara

Subjects
Male, Ovarian Neoplasms, Lung Neoplasms, Mental Disorders, Smoking, Inheritance Patterns, Prostatic Neoplasms, Breast Neoplasms, Polymorphism, Single Nucleotide, White People, 3. Good health, Neoplasm Proteins, Phenotype, Head and Neck Neoplasms, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Colorectal Neoplasms, Genome-Wide Association Study
Abstract

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

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