9 results on '"Tucker, Nathan R."'
Search Results
2. Transcriptome variation in human tissues revealed by long-read sequencing
- Author
-
Glinos, Dafni A., primary, Garborcauskas, Garrett, additional, Hoffman, Paul, additional, Ehsan, Nava, additional, Jiang, Lihua, additional, Gokden, Alper, additional, Dai, Xiaoguang, additional, Aguet, François, additional, Brown, Kathleen L., additional, Garimella, Kiran, additional, Bowers, Tera, additional, Costello, Maura, additional, Ardlie, Kristin, additional, Jian, Ruiqi, additional, Tucker, Nathan R., additional, Ellinor, Patrick T., additional, Harrington, Eoghan D., additional, Tang, Hua, additional, Snyder, Michael, additional, Juul, Sissel, additional, Mohammadi, Pejman, additional, MacArthur, Daniel G., additional, Lappalainen, Tuuli, additional, and Cummings, Beryl B., additional
- Published
- 2022
- Full Text
- View/download PDF
3. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy
- Author
-
Chaffin, Mark, primary, Papangeli, Irinna, additional, Simonson, Bridget, additional, Akkad, Amer-Denis, additional, Hill, Matthew C., additional, Arduini, Alessandro, additional, Fleming, Stephen J., additional, Melanson, Michelle, additional, Hayat, Sikander, additional, Kost-Alimova, Maria, additional, Atwa, Ondine, additional, Ye, Jiangchuan, additional, Bedi, Kenneth C., additional, Nahrendorf, Matthias, additional, Kaushik, Virendar K., additional, Stegmann, Christian M., additional, Margulies, Kenneth B., additional, Tucker, Nathan R., additional, and Ellinor, Patrick T., additional
- Published
- 2022
- Full Text
- View/download PDF
4. Deep learning enables genetic analysis of the human thoracic aorta
- Author
-
Pirruccello, James P., primary, Chaffin, Mark D., additional, Chou, Elizabeth L., additional, Fleming, Stephen J., additional, Lin, Honghuang, additional, Nekoui, Mahan, additional, Khurshid, Shaan, additional, Friedman, Samuel F., additional, Bick, Alexander G., additional, Arduini, Alessandro, additional, Weng, Lu-Chen, additional, Choi, Seung Hoan, additional, Akkad, Amer-Denis, additional, Batra, Puneet, additional, Tucker, Nathan R., additional, Hall, Amelia W., additional, Roselli, Carolina, additional, Benjamin, Emelia J., additional, Vellarikkal, Shamsudheen K., additional, Gupta, Rajat M., additional, Stegmann, Christian M., additional, Juric, Dejan, additional, Stone, James R., additional, Vasan, Ramachandran S., additional, Ho, Jennifer E., additional, Hoffmann, Udo, additional, Lubitz, Steven A., additional, Philippakis, Anthony A., additional, Lindsay, Mark E., additional, and Ellinor, Patrick T., additional
- Published
- 2021
- Full Text
- View/download PDF
5. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
- Author
-
Ntalla, Ioanna, primary, Weng, Lu-Chen, additional, Cartwright, James H., additional, Hall, Amelia Weber, additional, Sveinbjornsson, Gardar, additional, Tucker, Nathan R., additional, Choi, Seung Hoan, additional, Chaffin, Mark D., additional, Roselli, Carolina, additional, Barnes, Michael R., additional, Mifsud, Borbala, additional, Warren, Helen R., additional, Hayward, Caroline, additional, Marten, Jonathan, additional, Cranley, James J., additional, Concas, Maria Pina, additional, Gasparini, Paolo, additional, Boutin, Thibaud, additional, Kolcic, Ivana, additional, Polasek, Ozren, additional, Rudan, Igor, additional, Araujo, Nathalia M., additional, Lima-Costa, Maria Fernanda, additional, Ribeiro, Antonio Luiz P., additional, Souza, Renan P., additional, Tarazona-Santos, Eduardo, additional, Giedraitis, Vilmantas, additional, Ingelsson, Erik, additional, Mahajan, Anubha, additional, Morris, Andrew P., additional, Del Greco M, Fabiola, additional, Foco, Luisa, additional, Gögele, Martin, additional, Hicks, Andrew A., additional, Cook, James P., additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Sundström, Johan, additional, Nelson, Christopher P., additional, Riaz, Muhammad B., additional, Samani, Nilesh J., additional, Sinagra, Gianfranco, additional, Ulivi, Sheila, additional, Kähönen, Mika, additional, Mishra, Pashupati P., additional, Mononen, Nina, additional, Nikus, Kjell, additional, Caulfield, Mark J., additional, Dominiczak, Anna, additional, Padmanabhan, Sandosh, additional, Montasser, May E., additional, O’Connell, Jeff R., additional, Ryan, Kathleen, additional, Shuldiner, Alan R., additional, Aeschbacher, Stefanie, additional, Conen, David, additional, Risch, Lorenz, additional, Thériault, Sébastien, additional, Hutri-Kähönen, Nina, additional, Lehtimäki, Terho, additional, Lyytikäinen, Leo-Pekka, additional, Raitakari, Olli T., additional, Barnes, Catriona L. K., additional, Campbell, Harry, additional, Joshi, Peter K., additional, Wilson, James F., additional, Isaacs, Aaron, additional, Kors, Jan A., additional, van Duijn, Cornelia M., additional, Huang, Paul L., additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Launer, Lenore J., additional, Smith, Albert V., additional, Bottinger, Erwin P., additional, Loos, Ruth J. F., additional, Nadkarni, Girish N., additional, Preuss, Michael H., additional, Correa, Adolfo, additional, Mei, Hao, additional, Wilson, James, additional, Meitinger, Thomas, additional, Müller-Nurasyid, Martina, additional, Peters, Annette, additional, Waldenberger, Melanie, additional, Mangino, Massimo, additional, Spector, Timothy D., additional, Rienstra, Michiel, additional, van de Vegte, Yordi J., additional, van der Harst, Pim, additional, Verweij, Niek, additional, Kääb, Stefan, additional, Schramm, Katharina, additional, Sinner, Moritz F., additional, Strauch, Konstantin, additional, Cutler, Michael J., additional, Fatkin, Diane, additional, London, Barry, additional, Olesen, Morten, additional, Roden, Dan M., additional, Benjamin Shoemaker, M., additional, Gustav Smith, J., additional, Biggs, Mary L., additional, Bis, Joshua C., additional, Brody, Jennifer A., additional, Psaty, Bruce M., additional, Rice, Kenneth, additional, Sotoodehnia, Nona, additional, De Grandi, Alessandro, additional, Fuchsberger, Christian, additional, Pattaro, Cristian, additional, Pramstaller, Peter P., additional, Ford, Ian, additional, Wouter Jukema, J., additional, Macfarlane, Peter W., additional, Trompet, Stella, additional, Dörr, Marcus, additional, Felix, Stephan B., additional, Völker, Uwe, additional, Weiss, Stefan, additional, Havulinna, Aki S., additional, Jula, Antti, additional, Sääksjärvi, Katri, additional, Salomaa, Veikko, additional, Guo, Xiuqing, additional, Heckbert, Susan R., additional, Lin, Henry J., additional, Rotter, Jerome I., additional, Taylor, Kent D., additional, Yao, Jie, additional, de Mutsert, Renée, additional, Maan, Arie C., additional, Mook-Kanamori, Dennis O., additional, Noordam, Raymond, additional, Cucca, Francesco, additional, Ding, Jun, additional, Lakatta, Edward G., additional, Qian, Yong, additional, Tarasov, Kirill V., additional, Levy, Daniel, additional, Lin, Honghuang, additional, Newton-Cheh, Christopher H., additional, Lunetta, Kathryn L., additional, Murray, Alison D., additional, Porteous, David J., additional, Smith, Blair H., additional, Stricker, Bruno H., additional, Uitterlinden, André, additional, van den Berg, Marten E., additional, Haessler, Jeffrey, additional, Jackson, Rebecca D., additional, Kooperberg, Charles, additional, Peters, Ulrike, additional, Reiner, Alexander P., additional, Whitsel, Eric A., additional, Alonso, Alvaro, additional, Arking, Dan E., additional, Boerwinkle, Eric, additional, Ehret, Georg B., additional, Soliman, Elsayed Z., additional, Avery, Christy L., additional, Gogarten, Stephanie M., additional, Kerr, Kathleen F., additional, Laurie, Cathy C., additional, Seyerle, Amanda A., additional, Stilp, Adrienne, additional, Assa, Solmaz, additional, Abdullah Said, M., additional, Yldau van der Ende, M., additional, Lambiase, Pier D., additional, Orini, Michele, additional, Ramirez, Julia, additional, Van Duijvenboden, Stefan, additional, Arnar, David O., additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Sulem, Patrick, additional, Thorleifsson, Gudmar, additional, Thorolfsdottir, Rosa B., additional, Thorsteinsdottir, Unnur, additional, Benjamin, Emelia J., additional, Tinker, Andrew, additional, Stefansson, Kari, additional, Ellinor, Patrick T., additional, Jamshidi, Yalda, additional, Lubitz, Steven A., additional, and Munroe, Patricia B., additional
- Published
- 2020
- Full Text
- View/download PDF
6. Multi-ethnic genome-wide association study for atrial fibrillation
- Author
-
Roselli, Carolina, primary, Chaffin, Mark D., additional, Weng, Lu-Chen, additional, Aeschbacher, Stefanie, additional, Ahlberg, Gustav, additional, Albert, Christine M., additional, Almgren, Peter, additional, Alonso, Alvaro, additional, Anderson, Christopher D., additional, Aragam, Krishna G., additional, Arking, Dan E., additional, Barnard, John, additional, Bartz, Traci M., additional, Benjamin, Emelia J., additional, Bihlmeyer, Nathan A., additional, Bis, Joshua C., additional, Bloom, Heather L., additional, Boerwinkle, Eric, additional, Bottinger, Erwin B., additional, Brody, Jennifer A., additional, Calkins, Hugh, additional, Campbell, Archie, additional, Cappola, Thomas P., additional, Carlquist, John, additional, Chasman, Daniel I., additional, Chen, Lin Y., additional, Chen, Yii-Der Ida, additional, Choi, Eue-Keun, additional, Choi, Seung Hoan, additional, Christophersen, Ingrid E., additional, Chung, Mina K., additional, Cole, John W., additional, Conen, David, additional, Cook, James, additional, Crijns, Harry J., additional, Cutler, Michael J., additional, Damrauer, Scott M., additional, Daniels, Brian R., additional, Darbar, Dawood, additional, Delgado, Graciela, additional, Denny, Joshua C., additional, Dichgans, Martin, additional, Dörr, Marcus, additional, Dudink, Elton A., additional, Dudley, Samuel C., additional, Esa, Nada, additional, Esko, Tonu, additional, Eskola, Markku, additional, Fatkin, Diane, additional, Felix, Stephan B., additional, Ford, Ian, additional, Franco, Oscar H., additional, Geelhoed, Bastiaan, additional, Grewal, Raji P., additional, Gudnason, Vilmundur, additional, Guo, Xiuqing, additional, Gupta, Namrata, additional, Gustafsson, Stefan, additional, Gutmann, Rebecca, additional, Hamsten, Anders, additional, Harris, Tamara B., additional, Hayward, Caroline, additional, Heckbert, Susan R., additional, Hernesniemi, Jussi, additional, Hocking, Lynne J., additional, Hofman, Albert, additional, Horimoto, Andrea R. V. R., additional, Huang, Jie, additional, Huang, Paul L., additional, Huffman, Jennifer, additional, Ingelsson, Erik, additional, Ipek, Esra Gucuk, additional, Ito, Kaoru, additional, Jimenez-Conde, Jordi, additional, Johnson, Renee, additional, Jukema, J. Wouter, additional, Kääb, Stefan, additional, Kähönen, Mika, additional, Kamatani, Yoichiro, additional, Kane, John P., additional, Kastrati, Adnan, additional, Kathiresan, Sekar, additional, Katschnig-Winter, Petra, additional, Kavousi, Maryam, additional, Kessler, Thorsten, additional, Kietselaer, Bas L., additional, Kirchhof, Paulus, additional, Kleber, Marcus E., additional, Knight, Stacey, additional, Krieger, Jose E., additional, Kubo, Michiaki, additional, Launer, Lenore J., additional, Laurikka, Jari, additional, Lehtimäki, Terho, additional, Leineweber, Kirsten, additional, Lemaitre, Rozenn N., additional, Li, Man, additional, Lim, Hong Euy, additional, Lin, Henry J., additional, Lin, Honghuang, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Lokki, Marja-Liisa, additional, London, Barry, additional, Loos, Ruth J. F., additional, Low, Siew-Kee, additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, Macfarlane, Peter W., additional, Magnusson, Patrik K., additional, Mahajan, Anubha, additional, Malik, Rainer, additional, Mansur, Alfredo J., additional, Marcus, Gregory M., additional, Margolin, Lauren, additional, Margulies, Kenneth B., additional, März, Winfried, additional, McManus, David D., additional, Melander, Olle, additional, Mohanty, Sanghamitra, additional, Montgomery, Jay A., additional, Morley, Michael P., additional, Morris, Andrew P., additional, Müller-Nurasyid, Martina, additional, Natale, Andrea, additional, Nazarian, Saman, additional, Neumann, Benjamin, additional, Newton-Cheh, Christopher, additional, Niemeijer, Maartje N., additional, Nikus, Kjell, additional, Nilsson, Peter, additional, Noordam, Raymond, additional, Oellers, Heidi, additional, Olesen, Morten S., additional, Orho-Melander, Marju, additional, Padmanabhan, Sandosh, additional, Pak, Hui-Nam, additional, Paré, Guillaume, additional, Pedersen, Nancy L., additional, Pera, Joanna, additional, Pereira, Alexandre, additional, Porteous, David, additional, Psaty, Bruce M., additional, Pulit, Sara L., additional, Pullinger, Clive R., additional, Rader, Daniel J., additional, Refsgaard, Lena, additional, Ribasés, Marta, additional, Ridker, Paul M., additional, Rienstra, Michiel, additional, Risch, Lorenz, additional, Roden, Dan M., additional, Rosand, Jonathan, additional, Rosenberg, Michael A., additional, Rost, Natalia, additional, Rotter, Jerome I., additional, Saba, Samir, additional, Sandhu, Roopinder K., additional, Schnabel, Renate B., additional, Schramm, Katharina, additional, Schunkert, Heribert, additional, Schurman, Claudia, additional, Scott, Stuart A., additional, Seppälä, Ilkka, additional, Shaffer, Christian, additional, Shah, Svati, additional, Shalaby, Alaa A., additional, Shim, Jaemin, additional, Shoemaker, M. Benjamin, additional, Siland, Joylene E., additional, Sinisalo, Juha, additional, Sinner, Moritz F., additional, Slowik, Agnieszka, additional, Smith, Albert V., additional, Smith, Blair H., additional, Smith, J. Gustav, additional, Smith, Jonathan D., additional, Smith, Nicholas L., additional, Soliman, Elsayed Z., additional, Sotoodehnia, Nona, additional, Stricker, Bruno H., additional, Sun, Albert, additional, Sun, Han, additional, Svendsen, Jesper H., additional, Tanaka, Toshihiro, additional, Tanriverdi, Kahraman, additional, Taylor, Kent D., additional, Teder-Laving, Maris, additional, Teumer, Alexander, additional, Thériault, Sébastien, additional, Trompet, Stella, additional, Tucker, Nathan R., additional, Tveit, Arnljot, additional, Uitterlinden, Andre G., additional, Van Der Harst, Pim, additional, Van Gelder, Isabelle C., additional, Van Wagoner, David R., additional, Verweij, Niek, additional, Vlachopoulou, Efthymia, additional, Völker, Uwe, additional, Wang, Biqi, additional, Weeke, Peter E., additional, Weijs, Bob, additional, Weiss, Raul, additional, Weiss, Stefan, additional, Wells, Quinn S., additional, Wiggins, Kerri L., additional, Wong, Jorge A., additional, Woo, Daniel, additional, Worrall, Bradford B., additional, Yang, Pil-Sung, additional, Yao, Jie, additional, Yoneda, Zachary T., additional, Zeller, Tanja, additional, Zeng, Lingyao, additional, Lubitz, Steven A., additional, Lunetta, Kathryn L., additional, and Ellinor, Patrick T., additional
- Published
- 2018
- Full Text
- View/download PDF
7. Mutation of a common amino acid in NKX2.5 results in dilated cardiomyopathy in two large families
- Author
-
Hanley, Alan, primary, Walsh, Katie A., additional, Joyce, Caroline, additional, McLellan, Michael A., additional, Clauss, Sebastian, additional, Hagen, Amaya, additional, Shea, Marisa A., additional, Tucker, Nathan R., additional, Lin, Honghuang, additional, Fahy, Gerard J., additional, and Ellinor, Patrick T., additional
- Published
- 2016
- Full Text
- View/download PDF
8. Hsp27 is persistently expressed in zebrafish skeletal and cardiac muscle tissues but dispensable for their morphogenesis
- Author
-
Tucker, Nathan R., primary, Ustyugov, Alexey, additional, Bryantsev, Anton L., additional, Konkel, Michael E., additional, and Shelden, Eric. A., additional
- Published
- 2009
- Full Text
- View/download PDF
9. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
- Author
-
Ntalla, Ioanna, Weng, Lu-Chen, Cartwright, James H, Hall, Amelia Weber, Sveinbjornsson, Gardar, Tucker, Nathan R, Choi, Seung Hoan, Chaffin, Mark D, Roselli, Carolina, Barnes, Michael R, Mifsud, Borbala, Warren, Helen R, Hayward, Caroline, Marten, Jonathan, Cranley, James J, Concas, Maria Pina, Gasparini, Paolo, Boutin, Thibaud, Kolcic, Ivana, Polasek, Ozren, Rudan, Igor, Araujo, Nathalia M, Lima-Costa, Maria Fernanda, Ribeiro, Antonio Luiz P, Souza, Renan P, Tarazona-Santos, Eduardo, Giedraitis, Vilmantas, Ingelsson, Erik, Mahajan, Anubha, Morris, Andrew P, Del Greco M, Fabiola, Foco, Luisa, Gögele, Martin, Hicks, Andrew A, Cook, James P, Lind, Lars, Lindgren, Cecilia M, Sundström, Johan, Nelson, Christopher P, Riaz, Muhammad B, Samani, Nilesh J, Sinagra, Gianfranco, Ulivi, Sheila, Kähönen, Mika, Mishra, Pashupati P, Mononen, Nina, Nikus, Kjell, Caulfield, Mark J, Dominiczak, Anna, Padmanabhan, Sandosh, Montasser, May E, O'Connell, Jeff R, Ryan, Kathleen, Shuldiner, Alan R, Aeschbacher, Stefanie, Conen, David, Risch, Lorenz, Thériault, Sébastien, Hutri-Kähönen, Nina, Lehtimäki, Terho, Lyytikäinen, Leo-Pekka, Raitakari, Olli T, Barnes, Catriona LK, Campbell, Harry, Joshi, Peter K, Wilson, James F, Isaacs, Aaron, Kors, Jan A, Van Duijn, Cornelia M, Huang, Paul L, Gudnason, Vilmundur, Harris, Tamara B, Launer, Lenore J, Smith, Albert V, Bottinger, Erwin P, Loos, Ruth JF, Nadkarni, Girish N, Preuss, Michael H, Correa, Adolfo, Mei, Hao, Wilson, James, Meitinger, Thomas, Müller-Nurasyid, Martina, Peters, Annette, Waldenberger, Melanie, Mangino, Massimo, Spector, Timothy D, Rienstra, Michiel, Van De Vegte, Yordi J, Van Der Harst, Pim, Verweij, Niek, Kääb, Stefan, Schramm, Katharina, Sinner, Moritz F, Strauch, Konstantin, Cutler, Michael J, Fatkin, Diane, London, Barry, Olesen, Morten, Roden, Dan M, Benjamin Shoemaker, M, Gustav Smith, J, Biggs, Mary L, Bis, Joshua C, Brody, Jennifer A, Psaty, Bruce M, Rice, Kenneth, Sotoodehnia, Nona, De Grandi, Alessandro, Fuchsberger, Christian, Pattaro, Cristian, Pramstaller, Peter P, Ford, Ian, Wouter Jukema, J, Macfarlane, Peter W, Trompet, Stella, Dörr, Marcus, Felix, Stephan B, Völker, Uwe, Weiss, Stefan, Havulinna, Aki S, Jula, Antti, Sääksjärvi, Katri, Salomaa, Veikko, Guo, Xiuqing, Heckbert, Susan R, Lin, Henry J, Rotter, Jerome I, Taylor, Kent D, Yao, Jie, De Mutsert, Renée, Maan, Arie C, Mook-Kanamori, Dennis O, Noordam, Raymond, Cucca, Francesco, Ding, Jun, Lakatta, Edward G, Qian, Yong, Tarasov, Kirill V, Levy, Daniel, Lin, Honghuang, Newton-Cheh, Christopher H, Lunetta, Kathryn L, Murray, Alison D, Porteous, David J, Smith, Blair H, Stricker, Bruno H, Uitterlinden, André, Van Den Berg, Marten E, Haessler, Jeffrey, Jackson, Rebecca D, Kooperberg, Charles, Peters, Ulrike, Reiner, Alexander P, Whitsel, Eric A, Alonso, Alvaro, Arking, Dan E, Boerwinkle, Eric, Ehret, Georg B, Soliman, Elsayed Z, Avery, Christy L, Gogarten, Stephanie M, Kerr, Kathleen F, Laurie, Cathy C, Seyerle, Amanda A, Stilp, Adrienne, Assa, Solmaz, Abdullah Said, M, Yldau Van Der Ende, M, Lambiase, Pier D, Orini, Michele, Ramirez, Julia, Van Duijvenboden, Stefan, Arnar, David O, Gudbjartsson, Daniel F, Holm, Hilma, Sulem, Patrick, Thorleifsson, Gudmar, Thorolfsdottir, Rosa B, Thorsteinsdottir, Unnur, Benjamin, Emelia J, Tinker, Andrew, Stefansson, Kari, Ellinor, Patrick T, Jamshidi, Yalda, Lubitz, Steven A, and Munroe, Patricia B
- Subjects
Male ,Multifactorial Inheritance ,Endophenotypes ,Quantitative Trait Loci ,Gene Expression ,Genetic Variation ,Arrhythmias, Cardiac ,3. Good health ,Electrocardiography ,Cardiovascular Diseases ,Genetic Loci ,Humans ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study - Abstract
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a multi-ancestry (N = 293,051) genome-wide association meta-analysis for the PR interval, discovering 202 loci of which 141 have not previously been reported. Variants at identified loci increase the percentage of heritability explained, from 33.5% to 62.6%. We observe enrichment for cardiac muscle developmental/contractile and cytoskeletal genes, highlighting key regulation processes for atrioventricular conduction. Additionally, 8 loci not previously reported harbor genes underlying inherited arrhythmic syndromes and/or cardiomyopathies suggesting a role for these genes in cardiovascular pathology in the general population. We show that polygenic predisposition to PR interval duration is an endophenotype for cardiovascular disease, including distal conduction disease, AF, and atrioventricular pre-excitation. These findings advance our understanding of the polygenic basis of cardiac conduction, and the genetic relationship between PR interval duration and cardiovascular disease.
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.