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20 results on '"Traore, Boubacar"'

1. Evidence for exposure dependent carriage of malaria parasites across the dry season: modelling analysis of longitudinal data

Author

Stadler, Eva, primary, Cromer, Deborah, additional, Ogunlade, Samson, additional, Ongoiba, Aissata, additional, Doumbo, Safiatou, additional, Kayentao, Kassoum, additional, Traore, Boubacar, additional, Crompton, Peter D., additional, Portugal, Silvia, additional, Davenport, Miles P., additional, and Khoury, David S., additional

Published
2023
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2. Author Correction: Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

Author

Andrade, Carolina M., primary, Fleckenstein, Hannah, additional, Thomson-Luque, Richard, additional, Doumbo, Safiatou, additional, Lima, Nathalia F., additional, Anderson, Carrie, additional, Hibbert, Julia, additional, Hopp, Christine S., additional, Tran, Tuan M., additional, Li, Shanping, additional, Niangaly, Moussa, additional, Cisse, Hamidou, additional, Doumtabe, Didier, additional, Skinner, Jeff, additional, Sturdevant, Dan, additional, Ricklefs, Stacy, additional, Virtaneva, Kimmo, additional, Asghar, Muhammad, additional, Homann, Manijeh Vafa, additional, Turner, Louise, additional, Martins, Joana, additional, Allman, Erik L., additional, N’Dri, Marie-Esther, additional, Winkler, Volker, additional, Llinás, Manuel, additional, Lavazec, Catherine, additional, Martens, Craig, additional, Färnert, Anna, additional, Kayentao, Kassoum, additional, Ongoiba, Aissata, additional, Lavstsen, Thomas, additional, Osório, Nuno S., additional, Otto, Thomas D., additional, Recker, Mario, additional, Traore, Boubacar, additional, Crompton, Peter D., additional, and Portugal, Silvia, additional

Published
2022
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3. Light-activated interlayer contraction in two-dimensional perovskites for high-efficiency solar cells

Author

Li, Wenbin, primary, Sidhik, Siraj, additional, Traore, Boubacar, additional, Asadpour, Reza, additional, Hou, Jin, additional, Zhang, Hao, additional, Fehr, Austin, additional, Essman, Joseph, additional, Wang, Yafei, additional, Hoffman, Justin M., additional, Spanopoulos, Ioannis, additional, Crochet, Jared J., additional, Tsai, Esther, additional, Strzalka, Joseph, additional, Katan, Claudine, additional, Alam, Muhammad A., additional, Kanatzidis, Mercouri G., additional, Even, Jacky, additional, Blancon, Jean-Christophe, additional, and Mohite, Aditya D., additional

Published
2021
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5. Structural basis of malaria RIFIN binding by LILRB1-containing antibodies

Author

Chen, Yiwei, primary, Xu, Kai, additional, Piccoli, Luca, additional, Foglierini, Mathilde, additional, Tan, Joshua, additional, Jin, Wenjie, additional, Gorman, Jason, additional, Tsybovsky, Yaroslav, additional, Zhang, Baoshan, additional, Traore, Boubacar, additional, Silacci-Fregni, Chiara, additional, Daubenberger, Claudia, additional, Crompton, Peter D., additional, Geiger, Roger, additional, Sallusto, Federica, additional, Kwong, Peter D., additional, and Lanzavecchia, Antonio, additional

Published
2021
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7. Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season

Author

Andrade, Carolina M., primary, Fleckenstein, Hannah, additional, Thomson-Luque, Richard, additional, Doumbo, Safiatou, additional, Lima, Nathalia F., additional, Anderson, Carrie, additional, Hibbert, Julia, additional, Hopp, Christine S., additional, Tran, Tuan M., additional, Li, Shanping, additional, Niangaly, Moussa, additional, Cisse, Hamidou, additional, Doumtabe, Didier, additional, Skinner, Jeff, additional, Sturdevant, Dan, additional, Ricklefs, Stacy, additional, Virtaneva, Kimmo, additional, Asghar, Muhammad, additional, Homann, Manijeh Vafa, additional, Turner, Louise, additional, Martins, Joana, additional, Allman, Erik L., additional, N’Dri, Marie-Esther, additional, Winkler, Volker, additional, Llinás, Manuel, additional, Lavazec, Catherine, additional, Martens, Craig, additional, Färnert, Anna, additional, Kayentao, Kassoum, additional, Ongoiba, Aissata, additional, Lavstsen, Thomas, additional, Osório, Nuno S., additional, Otto, Thomas D., additional, Recker, Mario, additional, Traore, Boubacar, additional, Crompton, Peter D., additional, and Portugal, Silvia, additional

Published
2020
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9. Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

Author

Pieper, Kathrin, primary, Tan, Joshua, additional, Piccoli, Luca, additional, Foglierini, Mathilde, additional, Barbieri, Sonia, additional, Chen, Yiwei, additional, Silacci-Fregni, Chiara, additional, Wolf, Tobias, additional, Jarrossay, David, additional, Anderle, Marica, additional, Abdi, Abdirahman, additional, Ndungu, Francis M., additional, Doumbo, Ogobara K., additional, Traore, Boubacar, additional, Tran, Tuan M., additional, Jongo, Said, additional, Zenklusen, Isabelle, additional, Crompton, Peter D., additional, Daubenberger, Claudia, additional, Bull, Peter C., additional, Sallusto, Federica, additional, and Lanzavecchia, Antonio, additional

Published
2017
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10. Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria

Author

Tran, Tuan M., primary, Jones, Marcus B., additional, Ongoiba, Aissata, additional, Bijker, Else M., additional, Schats, Remko, additional, Venepally, Pratap, additional, Skinner, Jeff, additional, Doumbo, Safiatou, additional, Quinten, Edwin, additional, Visser, Leo G., additional, Whalen, Elizabeth, additional, Presnell, Scott, additional, O’Connell, Elise M., additional, Kayentao, Kassoum, additional, Doumbo, Ogobara K., additional, Chaussabel, Damien, additional, Lorenzi, Hernan, additional, Nutman, Thomas B., additional, Ottenhoff, Tom H. M., additional, Haks, Mariëlle C., additional, Traore, Boubacar, additional, Kirkness, Ewen F., additional, Sauerwein, Robert W., additional, and Crompton, Peter D., additional

Published
2016
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11. Stool microbiota composition is associated with the prospective risk of Plasmodium falciparum infection

Author

Yooseph, Shibu, primary, Kirkness, Ewen F., additional, Tran, Tuan M., additional, Harkins, Derek M., additional, Jones, Marcus B., additional, Torralba, Manolito G., additional, O’Connell, Elise, additional, Nutman, Thomas B., additional, Doumbo, Safiatou, additional, Doumbo, Ogobara K., additional, Traore, Boubacar, additional, Crompton, Peter D., additional, and Nelson, Karen E., additional

Published
2015
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13. Parasite clearance following treatment with sulphadoxine-pyrimethamine for intermittent preventive treatment in Burkina-Faso and Mali: 42-day in vivo follow-up study

Author

Coulibaly, Sheick O, primary, Kayentao, Kassoum, additional, Taylor, Steve, additional, Guirou, Etienne A, additional, Khairallah, Carole, additional, Guindo, Nouhoun, additional, Djimde, Moussa, additional, Bationo, Richard, additional, Soulama, Alamissa, additional, Dabira, Edgar, additional, Barry, Binta, additional, Niangaly, Moussa, additional, Diakite, Hammadoun, additional, Konate, Sidiki, additional, Keita, Mohamed, additional, Traore, Boubacar, additional, Meshnick, Steve R, additional, Magnussen, Pascal, additional, Doumbo, Ogobara K, additional, and ter Kuile, Feiko O, additional

Published
2014
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18. Artemisinin-based combinations versus amodiaquine plus sulphadoxine-pyrimethamine for the treatment of uncomplicated malaria in Faladje, Mali

Author

Kayentao, Kassoum, primary, Maiga, Hamma, additional, Newman, Robert D, additional, McMorrow, Meredith L, additional, Hoppe, Annett, additional, Yattara, Oumar, additional, Traore, Hamidou, additional, Kone, Younoussou, additional, Guirou, Etienne A, additional, Saye, Renion, additional, Traore, Boubacar, additional, Djimde, Abdoulaye, additional, and Doumbo, Ogobara K, additional

Published
2009
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20. Public antibodies to malaria antigens generated by two LAIR1 insertion modalities

Author

Pieper, Kathrin, Tan, Joshua, Piccoli, Luca, Foglierini, Mathilde, Barbieri, Sonia, Chen, Yiwei, Silacci-Fregni, Chiara, Wolf, Tobias, Jarrossay, David, Anderle, Marica, Abdi, Abdirahman, Ndungu, Francis M, Doumbo, Ogobara K, Traore, Boubacar, Tran, Tuan M, Jongo, Said, Zenklusen, Isabelle, Crompton, Peter D, Daubenberger, Claudia, Bull, Peter C, Sallusto, Federica, and Lanzavecchia, Antonio

Subjects
Male, B-Lymphocytes, Erythrocytes, Genes, Immunoglobulin Heavy Chain, Plasmodium falciparum, Antibodies, Protozoan, Antigens, Protozoan, Blood Donors, Templates, Genetic, Introns, 3. Good health, Immunoglobulin Switch Region, Malaria, Europe, Mutagenesis, Insertional, Protein Domains, Humans, Female, VDJ Exons, Receptors, Immunologic, Immunoglobulin Heavy Chains, Immunologic Memory
Abstract

In two previously described donors, the extracellular domain of LAIR1, a collagen-binding inhibitory receptor encoded on chromosome 19 (ref. 1), was inserted between the V and DJ segments of an antibody. This insertion generated, through somatic mutations, broadly reactive antibodies against RIFINs, a type of variant antigen expressed on the surface of Plasmodium falciparum-infected erythrocytes. To investigate how frequently such antibodies are produced in response to malaria infection, we screened plasma from two large cohorts of individuals living in malaria-endemic regions. Here we report that 5-10% of malaria-exposed individuals, but none of the European blood donors tested, have high levels of LAIR1-containing antibodies that dominate the response to infected erythrocytes without conferring enhanced protection against febrile malaria. By analysing the antibody-producing B cell clones at the protein, cDNA and gDNA levels, we characterized additional LAIR1 insertions between the V and DJ segments and discovered a second insertion modality whereby the LAIR1 exon encoding the extracellular domain and flanking intronic sequences are inserted into the switch region. By exon shuffling, this mechanism leads to the production of bispecific antibodies in which the LAIR1 domain is precisely positioned at the elbow between the VH and CH1 domains. Additionally, in one donor the genomic DNA encoding the VH and CH1 domains was deleted, leading to the production of a camel-like LAIR1-containing antibody. Sequencing of the switch regions of memory B cells from European blood donors revealed frequent templated inserts originating from transcribed genes that, in rare cases, comprised exons with orientations and frames compatible with expression. These results reveal different modalities of LAIR1 insertion that lead to public and dominant antibodies against infected erythrocytes and suggest that insertion of templated DNA represents an additional mechanism of antibody diversification that can be selected in the immune response against pathogens and exploited for B cell engineering.

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