Search

Your search keyword '"Thorsteinsson, B."' showing total 9 results
Start Over Author "Thorsteinsson, B." Publisher springer science and business media llc
9 results on '"Thorsteinsson, B."'

1. Effect of metformin and insulin vs. placebo and insulin on whole body composition in overweight patients with type 2 diabetes: a randomized placebo-controlled trial

Author

Nordklint, A. K., primary, Almdal, T.P., additional, Vestergaard, P., additional, Lundby-Christensen, L., additional, Boesgaard, T.W., additional, Breum, L., additional, Gade-Rasmussen, B., additional, Sneppen, S.B., additional, Gluud, C., additional, Hemmingsen, B., additional, Perrild, H., additional, Madsbad, S., additional, Mathiesen, E.R., additional, Tarnow, L., additional, Thorsteinsson, B., additional, Vestergaard, H., additional, Lund, S.S., additional, and Eiken, P., additional

Published
2021
Full Text
View/download PDF

7. The relationship between plasma concentration and plasma disappearance rate of immunoreactive insulin in normal subjects

Author

Fugleberg S, Thorsteinsson B, Lund B, Bojsen F, Kølendorf K, and Bliddal H

Subjects
Immunoreactive insulin, medicine.medical_specialty, Kinetic model, Chemistry, Endocrinology, Diabetes and Metabolism, Insulin, medicine.medical_treatment, Plasma, Models, Biological, Kinetics, Endocrinology, Internal medicine, Plasma concentration, Internal Medicine, medicine, Humans, Plasma disappearance rate, Antigens, Constant infusion, Insulin degradation
Abstract

To investigate the mechanism of insulin degradation in normal subjects, a kinetic model of insulin disappearance was constructed: insulin was assumed to be extracted from plasma by two independent processes, one saturable and one non-saturable. On the basis of these assumptions, a linear (non-proportional) relationship between steady-state plasma insulin concentration and steady-state plasma disappearance rate was predicted over the concentration range studied. Constant infusion experiments were performed on eight healthy normal subjects, normoglycaemia and fasting plasma C-peptide concentrations being maintained during the experiments. Agreement was found between the predictions of the model and the experimental results, and it is concluded that insulin degradation in normal subjects may be described in terms of two processes: one that is saturated at physiological plasma insulin concentrations and one that is apparently non-saturable over a wide concentration range.

Published
1982

Catalog

Books, media, physical & digital resources
See catalog results