Search

Your search keyword '"Talha Badar"' showing total 7 results
Start Over Author "Talha Badar" Publisher springer science and business media llc
7 results on '"Talha Badar"'

1. Survival of TP53-mutated acute myeloid leukemia patients receiving allogeneic stem cell transplantation after first induction or salvage therapy: results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)

Author

Talha Badar, Ehab Atallah, Rory Shallis, Antoine N. Saliba, Anand Patel, Jan P. Bewersdorf, Justin Grenet, Maximilian Stahl, Adam Duvall, Madelyn Burkart, Neil Palmisiano, Danielle Bradshaw, Michal Kubiak, Shira Dinner, Aaron D. Goldberg, Yasmin Abaza, Guru Subramanian Guru Murthy, Vamsi Kota, and Mark R. Litzow

Subjects
Cancer Research, Oncology, Hematology
Published
2023

2. Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113 AML patients

Author

Michael Boyiadzis, Mei-Jie Zhang, Karen Chen, Hisham Abdel-Azim, Muhammad Bilal Abid, Mahmoud Aljurf, Ulrike Bacher, Talha Badar, Sherif M. Badawy, Minoo Battiwalla, Nelli Bejanyan, Vijaya Raj Bhatt, Valerie I. Brown, Paul Castillo, Jan Cerny, Edward A. Copelan, Charles Craddock, Bhagirathbhai Dholaria, Miguel Angel Diaz Perez, Christen L. Ebens, Robert Peter Gale, Siddhartha Ganguly, Lohith Gowda, Michael R. Grunwald, Shahrukh Hashmi, Gerhard C. Hildebrandt, Madiha Iqbal, Omer Jamy, Mohamed A. Kharfan-Dabaja, Nandita Khera, Hillard M. Lazarus, Richard Lin, Dipenkumar Modi, Sunita Nathan, Taiga Nishihori, Sagar S. Patel, Attaphol Pawarode, Wael Saber, Akshay Sharma, Melhem Solh, John L. Wagner, Trent Wang, Kirsten M. Williams, Lena E. Winestone, Baldeep Wirk, Amer Zeidan, Christopher S. Hourigan, Mark Litzow, Partow Kebriaei, Marcos de Lima, Kristin Page, and Daniel J. Weisdorf

Subjects
Cancer Research, Oncology, Hematology
Published
2022

3. Germline and Somatic Defects in DDX41 and its Impact on Myeloid Neoplasms

Author

Talha Badar and Timothy Chlon

Subjects
DEAD-box RNA Helicases, Leukemia, Myeloid, Acute, Cancer Research, Germ Cells, Myeloproliferative Disorders, Oncology, Myelodysplastic Syndromes, Humans, Hematology, Article
Abstract

PURPOSE OF REVIEW: While DDX41 mutation (m) is one of the most prevalent predisposition genes in adult myelodysplastic syndrome (MDS)/acute myeloid leukemia (AML), most patients do not always present with a family history of MDS/AML. In this review, we will be highlighting epidemiological data on DDX41m, roles of DDX41 in oncogenesis, mechanisms of clonal evolution with somatic DDX41m, and clinical phenotypes and management of MDS/AML in patients harboring DDX41m. RECENT FINDINGS: DDX41 encodes a DEAD-box helicase protein that is considered essential for cell growth and viability. High incidence of myeloid malignancies and other cancers in patients bearing DDX41m suggests that defects in DDX41 lead to loss of a tumor suppressor function, likely related to activities in RNA splicing and processing pathways. Seventy percent of cancer cases with DDX41m are associated with MDS/AML alone. More than 65% of familial cases harbor heterozygous germline frameshift mutations, of which p.D140Gfs*2 is the most common. A somatic DDX41m of the second allele is acquired in 70% of cases, leading to hematological malignancy. Myeloid neoplasms with DDX41m are typically characterized by long latency, high-risk disease at presentation with normal cytogenetics and without any additional molecular markers. Recent reports suggests that a subgroup of these patients have an indolent clinical course and have a better long-term survival compared to favorable or intermediate risk AML. SUMMARY: Distinct clinical/pathologic features and favorable outcomes in MDS/AML highlight the need for standardized classification and gene specific guidelines that could assist in management decisions in patients with DDX41m.

Published
2022

5. Abnormal karyotype is an independent predictor of inferior survival in Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Author

Mostafa Abdallah, Kristen McCullough, Rimal Ilyas, Kebede H. Begna, Aref Al-Kali, Mark R. Litzow, William J. Hogan, Abhishek Mangaonkar, Hassan Alkhateeb, Mithun V. Shah, Michelle A. Elliott, James M. Foran, Talha Badar, Jeanne M. Palmer, Cecilia Arana Yi, Lisa Sproat, Animesh Pardanani, Mrinal M. Patnaik, Horatiu Olteanu, Rhett P. Ketterling, Ayalew Tefferi, and Naseema Gangat

Subjects
Oncology, Hematology
Published
2023

7. Co-mutational pattern of somatic GATA2-mutated myeloid neoplasms

Author

Bahga Katamesh, Ahmad Nanaa, Rong He, David Viswanatha, Phuong Nguyen, Patricia Greipp, James Foran, Kebede Begna, Naseema Gangat, Mrinal Patnaik, Ayalew Tefferi, Mark Litzow, Abhishek Mangaonkar, Mithun Vinod Shah, Talha Badar, Hassan B. Alkhateeb, and Aref Al-Kali

Subjects
Hematology, General Medicine
Published
2022

Catalog

Books, media, physical & digital resources
See catalog results