1. [Untitled]
- Author
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T A Nazarenko, V I Kulakov, L. V. Vanko, Alexander V. Zhdanov, T G Gabuniya, M. P. Davydova, and Gennady T. Sukhikh
- Subjects
Regulation of gene expression ,Messenger RNA ,Cell growth ,medicine.medical_treatment ,Interleukin ,General Medicine ,Biology ,General Biochemistry, Genetics and Molecular Biology ,Cell biology ,Proinflammatory cytokine ,Cytokine ,Gene expression ,medicine ,Tumor necrosis factor alpha - Abstract
We studied expression of genes of interleukins, interferon-gamma, tumor necrosis factor-alpha, and transforming growth factor-beta(2) in adhesions on uterine tubes. In tubal adhesions the intensity of production of mRNA for proinflammatory cytokines, antiinflammatory cytokine interleukin-10, and regulator of cell proliferation surpassed that in normal tissues by 2.5-7.4, 2.2, and 50.2 times, respectively. Correlations were found between production of mRNA for tumor necrosis factor-alpha and transforming growth factor-beta(2), interleukin-12, and interferon-gamma and interleukin-12 and transforming growth factor-beta(2). Our results suggest that expression of these genes during adhesion formation is regulated by the feedback mechanism.
- Published
- 2002