1. Genetic aspects in attention-deficit/hyperactivity disorder
- Author
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Özgür Albayrak, Anke Hinney, Benno G. Schimmelmann, Johannes Hebebrand, and Susann Friedel
- Subjects
Candidate gene ,medicine.medical_specialty ,Neurology ,Genome-wide association study ,Heritability ,GPI-Linked Proteins ,medicine.disease ,Serotonergic ,Psychiatry and Mental health ,Attention Deficit Disorder with Hyperactivity ,Risk Factors ,Genetics ,medicine ,Etiology ,Animals ,Humans ,Attention deficit hyperactivity disorder ,Neurology (clinical) ,Psychiatry ,Psychology ,Neural Cell Adhesion Molecules ,Biological Psychiatry ,Pharmacogenetics - Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder among children and adolescents with high heritability. Molecular genetic findings support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease. Genetic research comprises formal genetic studies, candidate gene studies, linkage analyses, and recently large-scale genome wide association studies, gene-environement interaction studies, and pharmacogenetics. This article comprehensively reviews the latest findings on the genetics of ADHD.
- Published
- 2008