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Start Over Author "Steinberg, Julia" Publisher springer science and business media llc
26 results on '"Steinberg, Julia"'

2. Colon and rectal cancer treatment patterns and their associations with clinical, sociodemographic and lifestyle characteristics: analysis of the Australian 45 and Up Study cohort

Author

Yap, Sarsha, primary, He, Emily, additional, Egger, Sam, additional, Goldsbury, David E, additional, Lew, Jie-Bin, additional, Ngo, Preston J, additional, Worthington, Joachim, additional, Rillstone, Hannah, additional, Zalcberg, John R, additional, Cuff, Jeff, additional, Ward, Robyn L, additional, Canfell, Karen, additional, Feletto, Eleonora, additional, and Steinberg, Julia, additional

Published
2023
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7. Family history, obesity, urological factors and diabetic medications and their associations with risk of prostate cancer diagnosis in a large prospective study

Author

Nair-Shalliker, Visalini, primary, Bang, Albert, additional, Egger, Sam, additional, Yu, Xue Qin, additional, Chiam, Karen, additional, Steinberg, Julia, additional, Patel, Manish I., additional, Banks, Emily, additional, O’Connell, Dianne L., additional, Armstrong, Bruce K., additional, and Smith, David P., additional

Published
2022
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9. Lynch syndrome testing of colorectal cancer patients in a high-income country with universal healthcare: a retrospective study of current practice and gaps in seven australian hospitals

Author

Steinberg, Julia, primary, Chan, Priscilla, additional, Hogden, Emily, additional, Tiernan, Gabriella, additional, Morrow, April, additional, Kang, Yoon-Jung, additional, He, Emily, additional, Venchiarutti, Rebecca, additional, Titterton, Leanna, additional, Sankey, Lucien, additional, Pearn, Amy, additional, Nichols, Cassandra, additional, McKay, Skye, additional, Hayward, Anne, additional, Egoroff, Natasha, additional, Engel, Alexander, additional, Gibbs, Peter, additional, Goodwin, Annabel, additional, Harris, Marion, additional, Kench, James G, additional, Pachter, Nicholas, additional, Parkinson, Bonny, additional, Pockney, Peter, additional, Ragunathan, Abiramy, additional, Smyth, Courtney, additional, Solomon, Michael, additional, Steffens, Daniel, additional, Toh, James Wei Tatt, additional, Wallace, Marina, additional, Canfell, Karen, additional, Gill, Anthony, additional, Macrae, Finlay, additional, Tucker, Kathy, additional, and Taylor, Natalie, additional

Published
2022
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10. Trends in colon and rectal cancer mortality in Australia from 1972 to 2015 and associated projections to 2040

Author

Luo, Qingwei, primary, Lew, Jie-Bin, additional, Steinberg, Julia, additional, Worthington, Joachim, additional, Yu, Xue Qin, additional, Caruana, Michael, additional, Soerjomataram, Isabelle, additional, Bray, Freddie, additional, Lawrance, Sheena, additional, Arcorace, Maria, additional, O’Connell, Dianne L., additional, Canfell, Karen, additional, and Feletto, Eleonora, additional

Published
2022
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11. Accurate categorisation of menopausal status for research studies: a step-by-step guide and detailed algorithm considering age, self-reported menopause and factors potentially masking the occurrence of menopause

Author

Yap, Sarsha, primary, Vassallo, Amy, additional, Goldsbury, David E., additional, Salagame, Usha, additional, Velentzis, Louiza, additional, Banks, Emily, additional, O’Connell, Dianne L., additional, Canfell, Karen, additional, and Steinberg, Julia, additional

Published
2022
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12. Publisher Correction: Accelerating functional gene discovery in osteoarthritis

Author

Butterfield, Natalie C., primary, Curry, Katherine F., additional, Steinberg, Julia, additional, Dewhurst, Hannah, additional, Komla-Ebri, Davide, additional, Mannan, Naila S., additional, Adoum, Anne-Tounsia, additional, Leitch, Victoria D., additional, Logan, John G., additional, Waung, Julian A., additional, Ghirardello, Elena, additional, Southam, Lorraine, additional, Youlten, Scott E., additional, Wilkinson, J. Mark, additional, McAninch, Elizabeth A., additional, Vancollie, Valerie E., additional, Kussy, Fiona, additional, White, Jacqueline K., additional, Lelliott, Christopher J., additional, Adams, David J., additional, Jacques, Richard, additional, Bianco, Antonio C., additional, Boyde, Alan, additional, Zeggini, Eleftheria, additional, Croucher, Peter I., additional, Williams, Graham R., additional, and Bassett, J. H. Duncan, additional

Published
2021
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13. A molecular quantitative trait locus map for osteoarthritis

Author

Steinberg, Julia, primary, Southam, Lorraine, additional, Roumeliotis, Theodoros I., additional, Clark, Matthew J., additional, Jayasuriya, Raveen L., additional, Swift, Diane, additional, Shah, Karan M., additional, Butterfield, Natalie C., additional, Brooks, Roger A., additional, McCaskie, Andrew W., additional, Bassett, J. H. Duncan, additional, Williams, Graham R., additional, Choudhary, Jyoti S., additional, Wilkinson, J. Mark, additional, and Zeggini, Eleftheria, additional

Published
2021
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15. Accelerating functional gene discovery in osteoarthritis

Author

Butterfield, Natalie C., primary, Curry, Katherine F., additional, Steinberg, Julia, additional, Dewhurst, Hannah, additional, Komla-Ebri, Davide, additional, Mannan, Naila S., additional, Adoum, Anne-Tounsia, additional, Leitch, Victoria D., additional, Logan, John G., additional, Waung, Julian A., additional, Ghirardello, Elena, additional, Southam, Lorraine, additional, Youlten, Scott E., additional, Wilkinson, J. Mark, additional, McAninch, Elizabeth A., additional, Vancollie, Valerie E., additional, Kussy, Fiona, additional, White, Jacqueline K., additional, Lelliott, Christopher J., additional, Adams, David J., additional, Jacques, Richard, additional, Bianco, Antonio C., additional, Boyde, Alan, additional, Zeggini, Eleftheria, additional, Croucher, Peter I., additional, Williams, Graham R., additional, and Bassett, J. H. Duncan, additional

Published
2021
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17. Comparing theory and non-theory based implementation approaches to improving referral practices in cancer genetics: a cluster randomised trial protocol

Author

Morrow, April, primary, Hogden, Emily, additional, Kang, Yoon-Jung, additional, Steinberg, Julia, additional, Canfell, Karen, additional, Solomon, Michael J., additional, Kench, James G., additional, Gill, Anthony J., additional, Shaw, Tim, additional, Pachter, Nicholas, additional, Parkinson, Bonny, additional, Wolfenden, Luke, additional, Mitchell, Gillian, additional, Macrae, Finlay, additional, Tucker, Kathy, additional, and Taylor, Natalie, additional

Published
2019
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19. Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis

Author

Zengini, Eleni, primary, Hatzikotoulas, Konstantinos, additional, Tachmazidou, Ioanna, additional, Steinberg, Julia, additional, Hartwig, Fernando P., additional, Southam, Lorraine, additional, Hackinger, Sophie, additional, Boer, Cindy G., additional, Styrkarsdottir, Unnur, additional, Gilly, Arthur, additional, Suveges, Daniel, additional, Killian, Britt, additional, Ingvarsson, Thorvaldur, additional, Jonsson, Helgi, additional, Babis, George C., additional, McCaskie, Andrew, additional, Uitterlinden, Andre G., additional, van Meurs, Joyce B. J., additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Davey Smith, George, additional, Wilkinson, Jeremy M., additional, and Zeggini, Eleftheria, additional

Published
2018
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20. Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

Author

Steinberg, Julia, primary, Ritchie, Graham R. S., additional, Roumeliotis, Theodoros I., additional, Jayasuriya, Raveen L., additional, Clark, Matthew J., additional, Brooks, Roger A., additional, Binch, Abbie L. A., additional, Shah, Karan M., additional, Coyle, Rachael, additional, Pardo, Mercedes, additional, Le Maitre, Christine L., additional, Ramos, Yolande F. M., additional, Nelissen, Rob G. H. H., additional, Meulenbelt, Ingrid, additional, McCaskie, Andrew W., additional, Choudhary, Jyoti S., additional, Wilkinson, J. Mark, additional, and Zeggini, Eleftheria, additional

Published
2017
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24. Accelerating functional gene discovery in osteoarthritis

Author

Butterfield, Natalie C, Curry, Katherine F, Steinberg, Julia, Dewhurst, Hannah, Komla-Ebri, Davide, Mannan, Naila S, Adoum, Anne-Tounsia, Leitch, Victoria D, Logan, John G, Waung, Julian A, Ghirardello, Elena, Southam, Lorraine, Youlten, Scott E, Wilkinson, J Mark, McAninch, Elizabeth A, Vancollie, Valerie E, Kussy, Fiona, White, Jacqueline K, Lelliott, Christopher J, Adams, David J, Jacques, Richard, Bianco, Antonio C, Boyde, Alan, Zeggini, Eleftheria, Croucher, Peter I, Williams, Graham R, and Bassett, JH Duncan

Subjects
Gene Editing, Mice, Knockout, Iodide Peroxidase, Bone and Bones, 3. Good health, Gonadotropin-Releasing Hormone, Disease Models, Animal, Mice, Cartilage, Phenotype, Drug Discovery, Osteoarthritis, Animals, Paired Box Transcription Factors, Clustered Regularly Interspaced Short Palindromic Repeats, Genetic Predisposition to Disease, CRISPR-Cas Systems, Genetic Association Studies
Abstract

Osteoarthritis causes debilitating pain and disability, resulting in a considerable socioeconomic burden, yet no drugs are available that prevent disease onset or progression. Here, we develop, validate and use rapid-throughput imaging techniques to identify abnormal joint phenotypes in randomly selected mutant mice generated by the International Knockout Mouse Consortium. We identify 14 genes with functional involvement in osteoarthritis pathogenesis, including the homeobox gene Pitx1, and functionally characterize 6 candidate human osteoarthritis genes in mouse models. We demonstrate sensitivity of the methods by identifying age-related degenerative joint damage in wild-type mice. Finally, we phenotype previously generated mutant mice with an osteoarthritis-associated polymorphism in the Dio2 gene by CRISPR/Cas9 genome editing and demonstrate a protective role in disease onset with public health implications. We hope this expanding resource of mutant mice will accelerate functional gene discovery in osteoarthritis and offer drug discovery opportunities for this common, incapacitating chronic disease.

25. Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis

Author

Steinberg, Julia, Ritchie, Graham RS, Roumeliotis, Theodoros I, Jayasuriya, Raveen L, Clark, Matthew J, Brooks, Roger A, Binch, Abbie LA, Shah, Karan M, Coyle, Rachael, Pardo, Mercedes, Le Maitre, Christine L, Ramos, Yolande FM, Nelissen, Rob GHH, Meulenbelt, Ingrid, McCaskie, Andrew W, Choudhary, Jyoti S, Wilkinson, J Mark, and Zeggini, Eleftheria

Subjects
Epigenomics, Male, Proteomics, Aquaporin 1, Sequence Analysis, RNA, Arthroplasty, Replacement, Hip, Gene Expression Profiling, DNA Methylation, Osteoarthritis, Knee, Collagen Type I, Mass Spectrometry, Osteoarthritis, Hip, 3. Good health, Epigenesis, Genetic, Collagen Type I, alpha 1 Chain, Chondrocytes, Case-Control Studies, Disease Progression, Humans, Gene Regulatory Networks, Lectins, C-Type, Arthroplasty, Replacement, Knee, Chromatography, Liquid
Abstract

Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint remodeling. The underlying molecular changes underpinning disease progression are incompletely understood. We investigated genes and pathways that mark OA progression in isolated primary chondrocytes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoing joint replacement surgery (discovery cohort: 12 knee OA, replication cohorts: 17 knee OA, 9 hip OA patients). We combined genome-wide DNA methylation, RNA sequencing, and quantitative proteomics data. We identified 49 genes differentially regulated between intact and degraded cartilage in at least two -omics levels, 16 of which have not previously been implicated in OA progression. Integrated pathway analysis implicated the involvement of extracellular matrix degradation, collagen catabolism and angiogenesis in disease progression. Using independent replication datasets, we showed that the direction of change is consistent for over 90% of differentially expressed genes and differentially methylated CpG probes. AQP1, COL1A1 and CLEC3B were significantly differentially regulated across all three -omics levels, confirming their differential expression in human disease. Through integration of genome-wide methylation, gene and protein expression data in human primary chondrocytes, we identified consistent molecular players in OA progression that replicated across independent datasets and that have translational potential.

26. A molecular quantitative trait locus map for osteoarthritis

Author

Steinberg, Julia, Southam, Lorraine, Roumeliotis, Theodoros I, Clark, Matthew J, Jayasuriya, Raveen L, Swift, Diane, Shah, Karan M, Butterfield, Natalie C, Brooks, Roger A, McCaskie, Andrew W, Bassett, JH Duncan, Williams, Graham R, Choudhary, Jyoti S, Wilkinson, J Mark, and Zeggini, Eleftheria

Subjects
Phenotype, Gene Expression Regulation, Gene Expression Profiling, Osteoarthritis, Quantitative Trait Loci, Humans, Genetic Predisposition to Disease, Transcriptome, 3. Good health, Genome-Wide Association Study, Transcription Factors
Abstract

Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell types. Here, we study primary cartilage and synovium from 115 patients with osteoarthritis to construct a deep molecular signature map of the disease. By integrating genetics with transcriptomics and proteomics, we discover molecular trait loci in each tissue type and omics level, identify likely effector genes for osteoarthritis-associated genetic signals and highlight high-value targets for drug development and repurposing. These findings provide insights into disease aetiopathology, and offer translational opportunities in response to the global clinical challenge of osteoarthritis.

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