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The Daniel K. Inouye Solar Telescope (DKIST) advances studies of solar magnetism through high-precision and accuracy in polarimetry at frontier spatial and temporal scales. A system model for polarization response in azimuth and altitude has been developed to calibrate DKIST instruments. The DKIST team has developed several new modeling and performance-estimation techniques coupled with thorough metrology. These efforts ensure that quality polarimetry is delivered to meet stringent accuracy requirements. A custom spectropolarimetric calibration system was designed, installed, and used to perform end-to-end calibration of the telescope using the beam within the Cryo-NIRSP instrument. Extensive optical and polarization characterization efforts allow for the reduction of systematic errors within a detailed system model that includes elliptical calibration retarders. Coating witness samples for every relevant optic in the system have been measured. Aperture-dependent variations in polarizer, retarder, and optic-coating performance have been measured and used to simulate both the polarization dependence on field angle and errors within the optical-system model. Multiple observations on-Sun and with a calibration lamp agree well with each other and with the system model. Upcoming multi-instrument observations are expected to be well calibrated with detailed understanding of major error limitations.

Most models of COVID-19 are implemented at a single micro or macro scale, ignoring the interplay between immune response, viral dynamics, individual infectiousness and epidemiological contact networks. Here we develop a data-driven model linking the within-host viral dynamics to the between-host transmission dynamics on a multilayer contact network to investigate the potential factors driving transmission dynamics and to inform how school closures and antiviral treatment can influence the epidemic. Using multi-source data, we initially determine the viral dynamics and estimate the relationship between viral load and infectiousness. Then, we embed the viral dynamics model into a four-layer contact network and formulate an agent-based model to simulate between-host transmission. The results illustrate that the heterogeneity of immune response between children and adults and between vaccinated and unvaccinated infections can produce different transmission patterns. We find that school closures play a significant effect on mitigating the pandemic as more adults get vaccinated and the virus mutates. If enough infected individuals are diagnosed by testing before symptom onset and then treated quickly, the transmission can be effectively curbed. Our multiscale model reveals the critical role played by younger individuals and antiviral treatment with testing in controlling the epidemic.

TheDiffraction-Limited Near-Infrared Spectropolarimeter(DL-NIRSP) is one of the first-light instruments for the National Science Foundation’sDaniel K. Inouye Solar Telescope(DKIST). DL-NIRSP is an integral-field, dual-beam spectropolarimeter intended for studying magnetically sensitive spectral lines in the Sun’s photosphere, chromosphere, and corona with high spectral resolution and polarimetric accuracy. Two novel fiber-optic integral-field units (IFUs), paired with selectable feed optics and a field-scanning mirror provide great flexibility in spatial sampling ($0.03^{\prime\prime}$0.03″,$0.08^{\prime\prime}$0.08″, and$0.5^{\prime \prime}$0.5″) and field coverage ($2^{\prime} \times 2^{\prime }$2′×2′). The IFUs allow DL-NIRSP to record all the spectra from a 2D field of view simultaneously, enabling the instrument to study the evolution of highly dynamic events. The spectrograph is an all-reflecting, near-Littrow design, which achieves a resolving power of approximately 125,000. Multiple wavelengths can be observed simultaneously using three spectral arms: one for visible wavelengths (500 – 900 nm) and two for infrared wavelengths (900 – 1350 nm and 1350 – 1800 nm). Each supporting camera sub-system is capable of a 30-Hz frame rate, making it possible to track dynamic phenomena on the Sun.

Despite the recent clinical success of T cell checkpoint inhibition targeting the CTLA-4 and PD-1 pathways, many patients either fail to achieve objective responses or they develop resistance to therapy. In some cases, poor responses to checkpoint blockade have been linked to suboptimal CD28 costimulation and the inability to generate and maintain a productive adaptive anti-tumor immune response. To address this, here we utilize directed evolution to engineer a CD80 IgV domain with increased PD-L1 affinity and fuse this to an immunoglobulin Fc domain, creating a therapeutic (ALPN-202, davoceticept) capable of providing CD28 costimulation in a PD-L1-dependent fashion while also antagonizing PD-1 - PD-L1 and CTLA-4–CD80/CD86 interactions. We demonstrate that by combining CD28 costimulation and dual checkpoint inhibition, ALPN-202 enhances T cell activation and anti-tumor efficacy in cell-based assays and mouse tumor models more potently than checkpoint blockade alone and thus has the potential to generate potent, clinically meaningful anti-tumor immunity in humans.

In a globally connected world, it is increasingly common for individuals to belong to and be influenced by more than one culture. Based on a critique of conceptualizations from psychology, management, marketing, anthropology, and sociology, we bring clarity and consistency to conceptualizing and measuring multiculturalism at the individual level. We propose that individual-level multiculturalism is the degree to which someone has knowledge of, identification with, and internalization of more than one societal culture, and recommend methods to measure each dimension. Finally, we suggest how individual-level multiculturalism influences, and is influenced by, social networks and power dynamics in international organizations.

Dietary data are used to categorize species diets, but these categorizations do not take into account the mutability of food resources in time or space, the level of interspecific competition in various communities as these resources change, nor the dietary flexibility of species. In this study, we assess the diets of three sympatric species, Eulemur rufifrons, Propithecus edwardsi, and Varecia variegata, in the Vatoharanana site in Ranomafana National Park, Madagascar. We determine dietary diversity, overlap, and interannual variation with data collected from 2001 to 2003. We then compare results on food preference and time feeding with data collected on each species in the late 1980s and early 1990s to determine whether these findings are consistent over the long term. We found little interannual variation in the proportion of time spent eating particular plant parts for each of the lemur species during the three study years (2001–2003), and between the earlier and current study. Food items were not always consumed based solely on availability. Dietary diversity was lower in the two frugivorous species (V. variegata and E. rufifrons) compared with the folivorous species (P. edwardsi), and V. variegata and E. rufifrons were more likely to focus their feeding time on one particular genus and plant part in each year. The study species used different strategies to deal with food, particularly fruit, shortages such as a plastic social structure (V. variegata), habitat shifting (E. rufifrons), and dietary switching (P. edwardsi). Although there was low dietary overlap between the study species, they depended on a small number of shared fruits in each of the study years (Chrysophyllum, Syzygium, Ocotea, Plagioscyphus), which may indicate some potential for interspecific competition. Because these lemur species, like all primates, lead relatively long lives (avg. >30 years) and have slow rates of aging, longitudinal studies are needed to test hypotheses reliant on basic dietary information.

International organizations, ranging from large MNCs to small born global firms, are increasingly recognizing that multicultural employees can help them operate across countries and across cultures. However, multiculturals – individuals who identify with and internalize more than one culture – are a diverse group, and organizations seeking to leverage their potential can benefit from a deeper understanding of the resources they possess and the challenges they face. We conducted three studies with a total of 1196 participants to test relationships between multicultural identity patterns and personal, social and task outcomes. Consistent results across studies indicated that individuals with more cultural identities (higher identity plurality) had more social capital and higher levels of intercultural skills than those with fewer cultural identities, while individuals who integrated their cultural identities (higher identity integration) experienced higher levels of personal well-being than those who separated them. Based on these results we advocate for two directions in future research on multicultural employees: moving beyond cognitive mechanisms alone, and examining monocultural and multicultural individuals simultaneously along the spectrum of identity plurality.

In four studies, we document an increase in the amount of negative feedback friends and colleagues exchange as their relationship deepens. We find that both actual and perceived relationship depth increase the amount of negative feedback people seek from and provide to each other, as well as their tendency to invest in a focal (relationship or performance) goal in response to negative feedback. The amount of positive feedback on goal pursuit, by contrast, remains stable as the relationship deepens. We attribute the increase in negative feedback to the different meaning of such feedback for people in deep versus shallow relationships: only in the context of deep relationships does negative feedback signal insufficient resource investment in the focal goal, and hence close friends and colleagues seek, provide, and respond to negative feedback.

Several factors can influence primate distributions, including evolutionary history, interspecific competition, climate, and anthropogenic impacts. In Madagascar, several small spatial scale studies have shown that anthropogenic habitat modification affects the density and distribution of many lemur species. Ecological niche models can be used to examine broad-scale influences of anthropogenic impacts on primate distributions. In this study, we examine how climate and anthropogenic factors influence the distribution of 11 Eulemur species using ecological niche models. Specifically, we created one set of models only using rainfall and temperature variables. We then created a second set of models that combined these climate variables with three anthropogenic factors: distance to dense settlements, villages, and croplands. We used MaxEnt to generate all the models. We found that the addition of anthropogenic variables improved the climate models. Also, most Eulemur species exhibited reduced predicted geographic distributions once anthropogenic factors were added to the model. Distance to dense settlements was the most important anthropogenic factor in most cases. We suggest that including anthropogenic variables in ecological niche models is important for understanding primate distributions, especially in regions with significant human impacts. In addition, we identify several Eulemur species that were most affected by anthropogenic factors and should be the focus of increased conservation efforts.

In recent years, there has been a surge in popularity of the fair-trade industry, which seeks to improve trading conditions and to promote the rights of marginalized workers. Although research suggests that fair-trade products are perceived as promoting social and economic responsibility, some individuals—namely, those who seek to maintain existing group inequalities (i.e., those high in social dominance orientation or SDO) or those induced to think inequality is a good thing—may not share this perception. Across three studies, we found that (1) SDO relates negatively to fair-trade consumption, and (2) this relationship is mediated by the tendency for high-SDO individuals to see fair-trade products as less compatible with their conception of social justice. Our findings held after controlling for related individual-differences variables, and regardless of whether SDO was measured or manipulated. Implications for how to maximize the likelihood that people will perceive fair-trade products as “fair” are discussed.

This research examines the effect of perceived closeness to a source of money on people’s likelihood to take financial risks. Across two experiments using gambling decision scenarios, we find that people make riskier choices when the monetary cost of the decision is high (vs. low) and when they perceive the source of the money as distant from (vs. close to) the self. Study 1 demonstrates that people make riskier decisions when someone else is paying than when they are paying, but only when the monetary cost of the gamble is relatively high (vs. low). Study 2 demonstrates that people make riskier decisions with a distant (vs. close) other’s money, presumably because they perceive a close (distant) other’s resources as similar to (different from) their own resources. The findings support the notion that the source of money affects how people mentally account for it, with proximity to the self as a determining factor.

We examined the relationship between gender and both job satisfaction and research productivity using data from 1,135 psychology faculty working in 229 academic departments. We found that gender differences in job satisfaction and research productivity were related to elements of the department (i.e., teaching orientation and structure). Overall, women reported lower levels of productivity than their male counterparts. Women also reported higher levels of job satisfaction in more teaching-oriented departments whereas men reported higher levels job satisfaction in more research-oriented departments. We suggest that these findings might be the result of gender differences in preferences with women preferring more socially-oriented positions and men prefer more “things/data”-oriented positions.

Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cancer, and emergence of drug resistance underscore the need to develop new, potentially less toxic alternatives. Our recent cross-sectional study in a large Appalachian population, showed a strong, inverse, dose–response association of serum perfluorooctane sulfonate (PFOS) levels to prevalent colorectal cancer, suggesting PFOS may have therapeutic potential in the prevention and/or treatment of colorectal cancer. In these preliminary studies using a mouse model of familial colorectal cancer, the APCmin mouse, and exposures comparable to those reported in human populations, we assess the efficacy of PFOS for reducing tumor burden, and evaluate potential dose–response effects. At 5–6 weeks of age, APCmin mice were randomized to receive 0, 20, 250 mg PFOS/kg (females) or 0, 10, 50 and 200 mg PFOS/kg (males) via their drinking water. At 15 weeks of age, gastrointestinal tumors were counted and scored and blood PFOS levels measured. PFOS exposure was associated with a significant, dose–response reduction in total tumor number in both male and female mice. This inverse dose–response effect of PFOS exposure was particularly pronounced for larger tumors (r2 for linear trend = 0.44 for males, p’s

Diel variation is known to alter the composition and structure of reef fish assemblages. What is unknown is how nocturnal fish assemblages respond to closed fishery area management. Diurnal and nocturnal reef fish assemblages at the Houtman Abrolhos Islands, Western Australia, were studied using baited remote underwater stereo-video systems (stereo-BRUVs). Surveys were conducted during the day and at night (using blue illumination) from three sites inside and three sites outside a closed fishery area (CFA). The relative abundance of 116 fish species from 41 families was recorded. Significant changes were observed in fish assemblage structure from day to night (driven by high dispersion at night) and in areas open versus closed to fishing (driven by increased abundance within the CFA). The effect of protection from fishing was consistent for both diurnal and nocturnal fish assemblages. Closer examination of six targeted fish species showed that their response to diel changes and the absence of fishing pressure varied from species to species. The targeted fishes Pagrus auratus and Glaucosoma hebraicum were sampled during the day and at night with both species responding positively to protection from fishing. Results suggest that the inclusion of diurnal and nocturnal fish assemblage data will provide an improved ability to assess the effectiveness of closed fishery area management.

In-stenting restenosis is one of the major complications after stenting. Clinical trials of various stent designs have reported different restenosis rates. However, quantitative correlation between stent features and restenosis statistics is scant. In this work, it is hypothesized that stress concentrations on arterial wall caused artery injury, which initiates restenosis. The goal is to assess the correlation between stent-induced arterial stress and strain and the documented restenosis rates Six commercially available stents, including balloon-expandable stents and self-expanding stents, were virtually implanted into the arteries through finite element method. The resulted peak Von Mises stress, principal stress, principal logarithm strain, as well as percentage of intimal area with abnormal higher stress were monitored. Positive correlation between arterial stress and strain after stent implantations and the documented restenosis rates from the corresponding clinical trials was found regardless of stent types. No statistical significant difference was observed for various stress or strain parameters serving as indicators of artery injury. In-stent restenosis are less likely to occur as arterial mechanics are least altered by stent implantations. Optimization of stent designs to minimize the stent-induced arterial stresses and strains can reduce the arterial injury, and thus reduce the occurrence of restenosis. This work improved our understanding of the stent-lesion interactions that regulate arterial mechanics and demonstrated that arterial stress and strain could predict the risk of in-stent restenosis.

Allomaternal care is a rare, though phylogenetically widespread, mammalian infant care strategy. Among primates, the effects of allomaternal care are marked; its presence correlates with faster infant growth, younger age at weaning, and shorter interbirth intervals. Recent comparative research has found that such fertility benefits are absent in other mammals and are thus unique to primates. In large part because data describing lemur allomaternal care were lacking, the reproductive advantages of allomaternal care have never been demonstrated in Malagasy strepsirrhines. Using newly available data and rigorous phylogenetic methods, we extend this hypothesis to strepsirrhines and test whether allomaternal care in lemurs confers similar maternal reproductive benefits. Contrary to expectations, the presence of allomaternal care did not significantly impact lemur reproductive output; we did not find relationships between allomaternal care and either fetal or postnatal growth rates or interbirth intervals. Rather, infant parking and nesting, strategies employed primarily by litter-bearing species, were positively associated with faster fetal and postnatal infant growth, while nesting was negatively associated with interbirth interval. Thus, although each form of haplorrhine allomaternal care is also observed in Malagasy primates, the effects that these behaviors have on female reproductive output more closely resemble nonprimate mammals. We suggest that Malagasy strepsirrhines may not equally benefit from allomaternal care compared to haplorrhines because reproductive rates are less flexible and allomaternal care may instead increase infant survival in Madagascar’s harsh and unpredictable environment. Our study has significant implications for understanding the evolution of infant care and developmental trajectories in mammals.

Purpose — Shape memory alloy (SMA) stents have been used increasingly for the treatment of complex arterial occlusions. There is an immediate need to quantify the mechanical performance of SMA stents to open occluded arteries. Methods — The stent crimping and expanding process was assessed through both numerical modeling and in-vitro studies. The implantation of a SMA stent in curved arteries with eccentric stenosis were simulated to evaluate the effect of artery curvature on arterial mechanics. Results — The crimping process stored a considerable amount of strain energy in the stent, which were then released through self-expansion until a balance between the stent and stenosed artery was achieved. The deployed SMA stent exhibited a dog-bone shape, where the longitudinal ends of the stent penetrated into the artery causing arterial stress concentrations. However, the maximum arterial stress was observed at the central portion of artery contacting the thin side of the plaque. Furthermore, stent-induced arterial mechanics were more pronounced in the curved artery than the straight artery. The maximum Von Mises stress in the curved artery with a curvature of 0.05 mm -1 was 37% larger than that found in the straight artery. The percentage of the intimal area at higher stress level (> 0.05 MPa) is 5.51% in the curved artery, compared to 1.76% in the straight artery. Conclusions — This work provided a fundamental understanding of the behavior of SMA stent and its impact on the vascular wall, and illuminated the possibilities for exploiting their potential to alleviate arterial injury.

Adherence to, and persistence with, treatments for osteoporosis are low. Adherence with teriparatide decreases over time. Higher copayments in the commercial/Medicare population were associated with worse persistence. Understanding factors such as prior screening, prior treatment history, and out of pocket costs that influence persistence with teriparatide may help clinicians make informed decisions.The purpose of this study was to evaluate adherence and persistence with teriparatide.Beneficiaries with at least one claim for teriparatide in 2003 or 2004 and continuous enrollment in the previous 12 months and subsequent 6 months were identified in a national commercial/Medicare and Medicaid administrative claims database (MarketScan®). Adherence was assessed through calculation of the medication possession ratio (MPR). Persistence was measured by time until discontinuation and time until first 60-day gap in treatment. Factors associated with persistence were assessed using Cox proportional hazards models.The average MPR at 6 months was 0.74 (N=2,218) and at 12 months, was 0.66 (N=1,303). At 6 months, 64.6% of patients remained on therapy and at 12 months, 56.7% remained. Bone mineral density screening and use of antiresorptive therapy within the 12 months pre-period, and lower patient copayments were associated with increased persistence.Patients appear to have good adherence with teriparatide over the first 6 months which declines over time. Prior screening and treatment of osteoporosis and out of pocket costs appear to impact persistence. To optimize patient outcomes, clinicians should consider clinical factors that impact persistence, while healthcare decision makers should consider the negative effect of higher patient copayments on persistence.

Highly seasonal breeding has been considered one of the keys to understanding Malagasy primate socioecology. Strict seasonal breeding may be particularly critical for Malagasy primates because they live in such energetically challenging seasonal environments. Lemurs also live in highly unpredictable environments, and there is growing evidence that reproductive timing may be mediated by additional factors, suggesting that more relaxed breeding seasonality is adaptive in some cases. I tested the adaptive breadth of the birth peak in Eulemur rubriventer, which breed in several different months. I describe reproduction in the species by determining the timing and extent of the birth season (period in which all births occur) and birth peak (period in which the majority of births occur); test whether relaxed reproductive seasonality might increase reproductive success by comparing infant mortality within and outside the birth peak; and model the extent to which fruit availability has an influence on the timing of reproduction. I collected birth data on 5 groups in 2003–2005, which I combined with demographic data that D. Overdorff collected from 5 focal groups and additional censused groups between 1988 and 1996. Thirty births occurred in 8 different months. Births were significantly seasonal, with a unimodal birth peak in late August/September/October, and a mean birth date of October 11. Twenty-three births (76.7%) occurred within 54 d (14.79%) of the year. No births occurred May–July, indicating that conceptions did not occur from late December through late February, and cycling (estimated using gestation length) did not occur until ca. 101 d after the austral summer solstice (December 21). Of 22 infants followed regularly, 18 were born in the birth peak, of which 2 died (11%). All 4 infants born out of season died. Based on fruit availability, I calculated a Theoretical Overlap index (T), which indicated a 3-mo window with optimal food conditions for reproduction. This window corresponded to the timing and breadth of the birth peak in Eulemur rubriventer. These results indicate that a breeding season >3 mo within a given year is not adaptive in the species, likely due in large part to the availability of fruit during key reproductive stages, particularly before breeding.

The demographic and clinical characteristics of patients initiating teriparatide were compared with those of patients initiating bisphosphonates for the treatment of osteoporosis. In these samples of commercially insured, Medicare, and Medicaid patients, patients initiating teriparatide were older, in poorer health, and appeared to have more severe osteoporosis than patients initiating bisphosphonates.The demographic and clinical characteristics of patients initiating teriparatide are compared with those of patients initiating bisphosphonates.Beneficiaries (45 years and older) with at least one claim for teriparatide or a bisphosphonate from 2003 to 2005 and continuous enrollment in the previous 12 months and subsequent 6 months were identified from commercial, Medicare, and Medicaid administrative claims databases. Patients initiating teriparatide (commercial/Medicare (N = 2,218); Medicaid (N = 824)) were compared to patients initiating bisphosphonates (commercial/Medicare (N = 97,570); Medicaid (N = 77,526)) in terms of age, provider specialty, comorbidities, prior use of osteoporosis medications, fractures, BMD screening, health status, and resource utilization.Teriparatide patients were older and in poorer health than bisphosphonate patients. Approximately 38% of teriparatide patients in both groups had fractured in the pre-period compared to 16% of commercial/Medicare and 15% of Medicaid bisphosphonate patients. Teriparatide patients were more likely to have used osteoporosis medications in the pre-period (79.9% versus 32.1% (commercial/Medicare); 82.2% versus 19.6% (Medicaid)).In these samples of patients, those initiating teriparatide differed from those initiating bisphosphonates. Teriparatide patients were older, in poorer health, and appeared to have more severe osteoporosis than bisphosphonate patients. Comparisons of treatment outcomes should take these differences in patient characteristics into consideration.

Human immunodeficiency virus (HIV) infection results in excessive apoptosis of infected and uninfected cells, mediated by host and viral factors present in plasma. As HIV protease inhibitors (PIs) have intrinsic antiapoptotic properties, we questioned whether HIV PIs could block HIV-induced CD4+ T-cell death independent of their effects on HIV replication. We demonstrate that HIV PIs block the death of CD4+ T cells induced by HIV glycoprotein 120 (gp120), Vpr, and Tat, as well as host signals Fas ligand, tumor necrosis factor, and tumor necrosis factor-related apoptosis-inducing ligand. Using gp120/CXCR4 as a model, we show that the HIV PIs specifically block mitochondrial apoptosis signaling. Furthermore, HIV PIs inhibit CD4+ T-cell death induced by viruses with high-level resistance to PIs (P

HIV protease inhibitors are an integral part of effective anti-HIV therapy. The drugs block HIV protease, prevent proper packaging of HIV virions, and decrease the HIV viral burden in the peripheral blood of infected individuals. In addition to direct anti-viral effects, the HIV protease inhibitors also modulate apoptosis. A growing body of work demonstrates the anti-apoptotic effects of HIV protease inhibitors on CD4+ and CD8+ T cells during HIV infection. The mechanism of this apoptosis inhibition is supported by several proposed hypotheses for how they alter the fate of the cell, including preventing adenine nucleotide translocator pore function, which consequently prevents loss of mitochondrial transmembrane potential. More recently, the anti-apoptotic effects of the HIV protease inhibitors have been tested in non-HIV, non-immune cell, whereby protease inhibitors prevent apoptosis, and disease in animal models of sepsis, hepatitis, pancreatitis and stroke. Interestingly, when HIV protease inhibitors are used at supra-therapeutic concentrations, they exert pro-apoptotic effects. This has been demonstrated in a number of tumor models. Although it is unclear how HIV protease inhibitors can induce apoptosis at increased concentrations, future research will define the targets of the immunomodulation and reveal the full clinical potential of this intriguing class of drugs.

Objective: To compare health expenditures among elderly Medicaid patients with asthma or chronic obstructive pulmonary disease (COPD) who used either nebulized levalbuterol (levosalbutamol) or racemic albuterol (salbutamol) for bronchodilation.

Since their discovery in 1998, the two TNF family members APRIL and BLyS/BAFF have received increasing attention. In addition to regulating normal B-cell development and immune responses, these molecules might be crucial in a diverse set of diseases, including autoimmunity and cancer. Although more has been published about the general biology of BLyS/BAFF than that of APRIL, many recent articles have described novel APRIL biology. Here we focus on APRIL, exploring its normal and pathological functions, and comparing the therapeutic molecules currently under development that target BLyS/BAFF alone, or APRIL and BLyS/BAFF together.

This study was designed to investigate work–family attitudes among emerging adults. Participants were 46 male and 49 female college juniors and seniors. Men and women had similar levels of work and family commitment. For women there was a negative correlation between work and family commitment. Exploratory analyses indicated different relationships between work decision-making status and commitment and family decision-making status and commitment. In addition, whereas men were more likely than women not yet to have thought about family roles, women were more likely than men to have decided about family roles. Implications of these findings for our understanding of the processes and meanings of emerging adult men's and women's decisions about entry into and commitment toward work and family roles are discussed.

T cell-derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleukin 31 (IL-31), which is preferentially produced by T helper type 2 cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. Expression of IL-31 receptor A and oncostatin M receptor mRNA was induced in activated monocytes, whereas epithelial cells expressed both mRNAs constitutively. Transgenic mice overexpressing IL-31 developed severe pruritus, alopecia and skin lesions. Furthermore, IL-31 receptor expression was increased in diseased tissues derived from an animal model of airway hypersensitivity. These data indicate that IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases.

This study examined patterns of care for women undergoing surgery for stress urinary incontinence (SUI). A retrospective analysis of administrative claims data was performed and we identified 12,520 women with a diagnosis of SUI and a subset of 3,735 women with a surgical procedure code for SUI. For the main types of surgeries, we examined length of stay, pharmaceutical use, complications, and healthcare utilization related to incontinence greater than 6 months after surgery. Approximately 30% of women with a coded SUI diagnosis underwent surgery. Of the initial procedures, 40% were retropubic suspensions and 25% were sling procedures. Almost 4% of women underwent an additional surgery, and 14.1% had claims related to incontinence 6 or more months after the initial procedure. We examined medical care and pharmaceutical use for women undergoing continence surgery. This information may be important to patients and physicians discussing treatment options.

In this study we examined college students' assessment of the personal meaningfulness of their families' rituals and their desire to initiate family rituals in the future. Participants were 46 male and 49 female never-married, primarily European American undergraduates at a private east coast university. It was found that women were more likely than men to see themselves initiating future family rituals. The amount of ritual initiation undertaken by participants' same-sex parents and participants' communality were significant predictors of reported likelihood of future ritual initiation. A “caring” parenting style was the only significant predictor of the meaningfulness of rituals. The relationships of respondents' religious and ethnic background and their parents' marital status to their attitudes toward rituals were also examined.

Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in lymphoid tissues and is capable of signal transduction. The full-length receptor was expressed in BaF3 cells, which created a functional assay for ligand detection and cloning. Conditioned media from activated human CD3+ T cells supported proliferation of the assay cell line. We constructed a complementary DNA expression library from activated human CD3+ T cells, and identified a cytokine with a four-helix-bundle structure using functional cloning. This cytokine is most closely related to IL2 and IL15, and has been designated IL21 with the receptor designated IL21 R. In vitro assays suggest that IL21 has a role in the proliferation and maturation of natural killer (NK) cell populations from bone marrow, in the proliferation of mature B-cell populations co-stimulated with anti-CD40, and in the proliferation of T cells co-stimulated with anti-CD3.