1. Assessment of Infant Brain Development With Frequency-Domain Near-Infrared Spectroscopy
- Author
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P. Ellen Grant, Kalpathy K. Krishnamoorthy, Sonal Thaker, Maria Angela Franceschini, George Themelis, Heather Bortfeld, Solomon G. Diamond, Kara Arvin, and David A. Boas
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Spectroscopy, Near-Infrared ,Brain development ,business.industry ,Near-infrared spectroscopy ,Brain ,Infant ,Near-Infrared Spectrometry ,Blood volume ,Non-ionizing radiation ,Article ,Cerebrovascular Circulation ,Oxygen Consumption ,Tissue oxygenation ,Regional Blood Flow ,Pediatrics, Perinatology and Child Health ,Oxygen delivery ,Humans ,Medicine ,business ,Biomedical engineering - Abstract
This is the first report to demonstrate quantitative monitoring of infant brain development with frequency-domain near-infrared spectroscopy (FD-NIRS). Regionally specific increases in blood volume and oxygen consumption were measured in healthy infants during their first year. The results agree with prior PET and SPECT reports; but, unlike these methods, FD-NIRS is portable and uses nonionizing radiation. Further, new information includes the relatively constant tissue oxygenation with age and location, suggesting a tight control between local oxygen delivery and consumption in healthy infants during brain development. FD-NIRS could become the preferred clinical tool for quantitatively assessing infant brain development.
- Published
- 2007
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