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394 results on '"Smith, A V"'

1. Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate

Author

Mack, Taralynn M., primary, Raddatz, Michael A., additional, Pershad, Yash, additional, Nachun, Daniel C., additional, Taylor, Kent D., additional, Guo, Xiuqing, additional, Shuldiner, Alan R., additional, O’Connell, Jeffrey R., additional, Kenny, Eimear E., additional, Loos, Ruth J. F., additional, Redline, Susan, additional, Cade, Brian E., additional, Psaty, Bruce M., additional, Bis, Joshua C., additional, Brody, Jennifer A., additional, Silverman, Edwin K., additional, Yun, Jeong H., additional, Cho, Michael H., additional, DeMeo, Dawn L., additional, Levy, Daniel, additional, Johnson, Andrew D., additional, Mathias, Rasika A., additional, Yanek, Lisa R., additional, Heckbert, Susan R., additional, Smith, Nicholas L., additional, Wiggins, Kerri L., additional, Raffield, Laura M., additional, Carson, April P., additional, Rotter, Jerome I., additional, Rich, Stephen S., additional, Manichaikul, Ani W., additional, Gu, C. Charles, additional, Chen, Yii-Der Ida, additional, Lee, Wen-Jane, additional, Shoemaker, M. Benjamin, additional, Roden, Dan M., additional, Kooperberg, Charles, additional, Auer, Paul L., additional, Desai, Pinkal, additional, Blackwell, Thomas W., additional, Smith, Albert V., additional, Reiner, Alexander P., additional, Jaiswal, Siddhartha, additional, Weinstock, Joshua S., additional, and Bick, Alexander G., additional

Published
2024
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3. “The Videos Made Me Feel Less Alone”: Feasible Executive Function Supports For Families

Author

Smith, Jessica V., primary, Dahlman, Tennyson, additional, Holmes, Jessica, additional, Armour, Chelsea A., additional, Verbalis, Alyssa, additional, Ratto, Allison B., additional, Hardy, Kristina K., additional, Gunn, Meredith, additional, Decker, Kaitlyn, additional, Brown, Dennard, additional, Elliott, Te’Andis, additional, Werner, Monica A., additional, Alexander, Katie C., additional, Cannon, Lynn, additional, Anthony, Bruno J., additional, Kenworthy, Lauren, additional, and Anthony, Laura G., additional

Published
2024
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5. Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification

Author

Kavousi, Maryam, primary, Bos, Maxime M., additional, Barnes, Hanna J., additional, Cardenas, Christian L. Lino, additional, Wong, Doris, additional, Lu, Haojie, additional, Hodonsky, Chani J., additional, Landsmeer, Lennart P. L., additional, Turner, Adam W., additional, Kho, Minjung, additional, Hasbani, Natalie R., additional, de Vries, Paul S., additional, Bowden, Donald W., additional, Chopade, Sandesh, additional, Deelen, Joris, additional, Benavente, Ernest Diez, additional, Guo, Xiuqing, additional, Hofer, Edith, additional, Hwang, Shih-Jen, additional, Lutz, Sharon M., additional, Lyytikäinen, Leo-Pekka, additional, Slenders, Lotte, additional, Smith, Albert V., additional, Stanislawski, Maggie A., additional, van Setten, Jessica, additional, Wong, Quenna, additional, Yanek, Lisa R., additional, Becker, Diane M., additional, Beekman, Marian, additional, Budoff, Matthew J., additional, Feitosa, Mary F., additional, Finan, Chris, additional, Hilliard, Austin T., additional, Kardia, Sharon L. R., additional, Kovacic, Jason C., additional, Kral, Brian G., additional, Langefeld, Carl D., additional, Launer, Lenore J., additional, Malik, Shaista, additional, Hoesein, Firdaus A. A. Mohamed, additional, Mokry, Michal, additional, Schmidt, Reinhold, additional, Smith, Jennifer A., additional, Taylor, Kent D., additional, Terry, James G., additional, van der Grond, Jeroen, additional, van Meurs, Joyce, additional, Vliegenthart, Rozemarijn, additional, Xu, Jianzhao, additional, Young, Kendra A., additional, Zilhão, Nuno R., additional, Zweiker, Robert, additional, Assimes, Themistocles L., additional, Becker, Lewis C., additional, Bos, Daniel, additional, Carr, J. Jeffrey, additional, Cupples, L. Adrienne, additional, de Kleijn, Dominique P. v., additional, de Winther, Menno, additional, den Ruijter, Hester M., additional, Fornage, Myriam, additional, Freedman, Barry I., additional, Gudnason, Vilmundur, additional, Hingorani, Aroon D., additional, Hokanson, John E., additional, Ikram, M. Arfan, additional, Išgum, Ivana, additional, Jacobs, David R., additional, Kähönen, Mika, additional, Lange, Leslie A., additional, Lehtimäki, Terho, additional, Pasterkamp, Gerard, additional, Raitakari, Olli T., additional, Schmidt, Helena, additional, Slagboom, P. Eline, additional, Uitterlinden, André G., additional, Vernooij, Meike W., additional, Bis, Joshua C., additional, Franceschini, Nora, additional, Psaty, Bruce M., additional, Post, Wendy S., additional, Rotter, Jerome I., additional, Björkegren, Johan L. M., additional, O’Donnell, Christopher J., additional, Bielak, Lawrence F., additional, Peyser, Patricia A., additional, Malhotra, Rajeev, additional, van der Laan, Sander W., additional, and Miller, Clint L., additional

Published
2023
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6. Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease

Author

Chen, Yanhua, primary, Du, Xiaomeng, additional, Kuppa, Annapurna, additional, Feitosa, Mary F., additional, Bielak, Lawrence F., additional, O’Connell, Jeffrey R., additional, Musani, Solomon K., additional, Guo, Xiuqing, additional, Kahali, Bratati, additional, Chen, Vincent L., additional, Smith, Albert V., additional, Ryan, Kathleen A., additional, Eirksdottir, Gudny, additional, Allison, Matthew A., additional, Bowden, Donald W., additional, Budoff, Matthew J., additional, Carr, John Jeffrey, additional, Chen, Yii-Der I., additional, Taylor, Kent D., additional, Oliveri, Antonino, additional, Correa, Adolfo, additional, Crudup, Breland F., additional, Kardia, Sharon L. R., additional, Mosley, Thomas H., additional, Norris, Jill M., additional, Terry, James G., additional, Rotter, Jerome I., additional, Wagenknecht, Lynne E., additional, Halligan, Brian D., additional, Young, Kendra A., additional, Hokanson, John E., additional, Washko, George R., additional, Gudnason, Vilmundur, additional, Province, Michael A., additional, Peyser, Patricia A., additional, Palmer, Nicholette D., additional, and Speliotes, Elizabeth K., additional

Published
2023
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7. Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease

Author

Sakaue, Saori, primary, Gurajala, Saisriram, additional, Curtis, Michelle, additional, Luo, Yang, additional, Choi, Wanson, additional, Ishigaki, Kazuyoshi, additional, Kang, Joyce B., additional, Rumker, Laurie, additional, Deutsch, Aaron J., additional, Schönherr, Sebastian, additional, Forer, Lukas, additional, LeFaive, Jonathon, additional, Fuchsberger, Christian, additional, Han, Buhm, additional, Lenz, Tobias L., additional, de Bakker, Paul I. W., additional, Okada, Yukinori, additional, Smith, Albert V., additional, and Raychaudhuri, Soumya, additional

Published
2023
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9. Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA

Author

Davies, Mark R., primary, Keller, Nadia, additional, Brouwer, Stephan, additional, Jespersen, Magnus G., additional, Cork, Amanda J., additional, Hayes, Andrew J., additional, Pitt, Miranda E., additional, De Oliveira, David M. P., additional, Harbison-Price, Nichaela, additional, Bertolla, Olivia M., additional, Mediati, Daniel G., additional, Curren, Bodie F., additional, Taiaroa, George, additional, Lacey, Jake A., additional, Smith, Helen V., additional, Fang, Ning-Xia, additional, Coin, Lachlan J. M., additional, Stevens, Kerrie, additional, Tong, Steven Y. C., additional, Sanderson-Smith, Martina, additional, Tree, Jai J., additional, Irwin, Adam D., additional, Grimwood, Keith, additional, Howden, Benjamin P., additional, Jennison, Amy V., additional, and Walker, Mark J., additional

Published
2023
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10. FixItFelix: improving genomic analysis by fixing reference errors

Author

Behera, Sairam, primary, LeFaive, Jonathon, additional, Orchard, Peter, additional, Mahmoud, Medhat, additional, Paulin, Luis F., additional, Farek, Jesse, additional, Soto, Daniela C., additional, Parker, Stephen C. J., additional, Smith, Albert V., additional, Dennis, Megan Y., additional, Zook, Justin M., additional, and Sedlazeck, Fritz J., additional

Published
2023
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12. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Author

Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Søren Karl, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, Swertz, Morris, Wijmenga, Tjitske Nienke, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Wolffenbuttel, Bruce H. R., Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., Hoed, Marcel den, Epidemiology, Internal Medicine, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine, Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J, Moore, Tim, Hyppönen, Elina, den Hoed, Marcel, Lifelines Cohort Study, Alizadeh, B.Z., Boezen, H.M., Franke, L., Swertz, M., Wijmenga, C., van der Harst, P., Navis, G., Rots, M., Wolffenbuttel, BHR, Wang, Zhe [0000-0002-8046-4969], Emmerich, Andrew [0000-0002-0908-9924], Pillon, Nicolas J [0000-0003-1107-9490], Moore, Tim [0000-0003-4250-3370], Ameur, Adam [0000-0001-6085-6749], Bis, Joshua C [0000-0002-3409-1110], Boehnke, Michael [0000-0002-6442-7754], Bouchard, Claude [0000-0002-0048-491X], Chasman, Daniel I [0000-0003-3357-0862], Smith, George Davey [0000-0002-1407-8314], de Geus, Eco JC [0000-0001-6022-2666], Dörr, Marcus [0000-0001-7471-475X], Ferrucci, Luigi [0000-0002-6273-1613], Fornage, Myriam [0000-0003-0677-8158], Garland, Theodore [0000-0002-7916-3552], Gyllensten, Ulf [0000-0002-6316-3355], Hansen, Torben [0000-0001-8748-3831], Horta, Bernardo L [0000-0001-9843-412X], Hyppönen, Elina [0000-0003-3670-9399], Johnson, W Craig [0000-0002-3161-3753], Kiemeney, Lambertus A [0000-0002-2368-1326], Laakso, Markku [0000-0002-3394-7749], Langenberg, Claudia [0000-0002-5017-7344], Lehtimäki, Terho [0000-0002-2555-4427], Magnusson, Patrik KE [0000-0002-7315-7899], Martin, Nicholas G [0000-0003-4069-8020], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Meyre, David [0000-0003-4850-7444], North, Kari E [0000-0002-8903-0366], Ohlsson, Claes [0000-0002-9633-2805], Oldehinkel, Albertine J [0000-0003-3925-3913], Orho-Melander, Marju [0000-0002-3578-2503], Pare, Guillaume [0000-0002-6795-4760], Park, Taesung [0000-0002-8294-590X], Pedersen, Oluf [0000-0002-3321-3972], Pers, Tune H [0000-0003-0207-4831], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Rotimi, Charles N [0000-0001-5759-053X], Sim, Xueling [0000-0002-1233-7642], Snieder, Harold [0000-0003-1949-2298], Sørensen, Thorkild IA [0000-0003-4821-430X], Spector, Tim D [0000-0002-9795-0365], Timpson, Nicholas J [0000-0002-7141-9189], Voortman, Trudy [0000-0003-2830-6813], Waeber, Gérard [0000-0003-4193-788X], Wareham, Nicholas J [0000-0003-1422-2993], Weir, David R [0000-0002-1661-2402], Wilson, James F [0000-0001-5751-9178], Krook, Anna [0000-0002-0891-0258], Zierath, Juleen R [0000-0001-6891-7497], Thomis, Martine AI [0000-0001-9093-2191], Loos, Ruth JF [0000-0002-8532-5087], Hoed, Marcel den [0000-0001-8081-428X], Apollo - University of Cambridge Repository, Center for Liver, Digestive and Metabolic Diseases (CLDM), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Geriatrics, AMS - Ageing & Vitality, APH - Aging & Later Life, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, and AMS - Sports

Subjects
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 631/208/205/2138, 610 Medicine & health, heritability, Actinin/genetics, Cross-Sectional Studies, Exercise/physiology, Genome-Wide Association Study, Humans, Leisure Activities, Sedentary Behavior, apolipoprotein-e genotype, Lifelines Cohort Study, 360 Social problems & social services, 692/308/575, Genetics, Actinin, Exercise, Medicinsk genetik, exercise, APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS, 360 Soziale Probleme, Sozialdienste, 692/308/2056, article, gwas, gene-expression, mortality, 3142 Public health care science, environmental and occupational health, fitness, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], LD score regression, 3111 Biomedicine, 610 Medizin und Gesundheit, Medical Genetics, complex, performance
Abstract

Funder: Kjell och Märta Beijers Stiftelse (Kjell and Marta Beijer Foundation); doi: https://doi.org/10.13039/501100006353, Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.

Published
2022
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13. Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program

Author

Wheeler, Marsha M., primary, Stilp, Adrienne M., additional, Rao, Shuquan, additional, Halldórsson, Bjarni V., additional, Beyter, Doruk, additional, Wen, Jia, additional, Mihkaylova, Anna V., additional, McHugh, Caitlin P., additional, Lane, John, additional, Jiang, Min-Zhi, additional, Raffield, Laura M., additional, Jun, Goo, additional, Sedlazeck, Fritz J., additional, Metcalf, Ginger, additional, Yao, Yao, additional, Bis, Joshua B., additional, Chami, Nathalie, additional, de Vries, Paul S., additional, Desai, Pinkal, additional, Floyd, James S., additional, Gao, Yan, additional, Kammers, Kai, additional, Kim, Wonji, additional, Moon, Jee-Young, additional, Ratan, Aakrosh, additional, Yanek, Lisa R., additional, Almasy, Laura, additional, Becker, Lewis C., additional, Blangero, John, additional, Cho, Michael H., additional, Curran, Joanne E., additional, Fornage, Myriam, additional, Kaplan, Robert C., additional, Lewis, Joshua P., additional, Loos, Ruth J. F., additional, Mitchell, Braxton D., additional, Morrison, Alanna C., additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Tang, Hua, additional, Tracy, Russell P., additional, Boerwinkle, Eric, additional, Abecasis, Goncalo R., additional, Blackwell, Thomas W., additional, Smith, Albert V., additional, Johnson, Andrew D., additional, Mathias, Rasika A., additional, Nickerson, Deborah A., additional, Conomos, Matthew P., additional, Li, Yun, additional, Þorsteinsdóttir, Unnur, additional, Magnússon, Magnús K., additional, Stefansson, Kari, additional, Pankratz, Nathan D., additional, Bauer, Daniel E., additional, Auer, Paul L., additional, and Reiner, Alex P., additional

Published
2022
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19. Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Author

Lahti, Jari, primary, Tuominen, Samuli, additional, Yang, Qiong, additional, Pergola, Giulio, additional, Ahmad, Shahzad, additional, Amin, Najaf, additional, Armstrong, Nicola J., additional, Beiser, Alexa, additional, Bey, Katharina, additional, Bis, Joshua C., additional, Boerwinkle, Eric, additional, Bressler, Jan, additional, Campbell, Archie, additional, Campbell, Harry, additional, Chen, Qiang, additional, Corley, Janie, additional, Cox, Simon R., additional, Davies, Gail, additional, De Jager, Philip L., additional, Derks, Eske M., additional, Faul, Jessica D., additional, Fitzpatrick, Annette L., additional, Fohner, Alison E., additional, Ford, Ian, additional, Fornage, Myriam, additional, Gerring, Zachary, additional, Grabe, Hans J., additional, Grodstein, Francine, additional, Gudnason, Vilmundur, additional, Simonsick, Eleanor, additional, Holliday, Elizabeth G., additional, Joshi, Peter K., additional, Kajantie, Eero, additional, Kaprio, Jaakko, additional, Karell, Pauliina, additional, Kleineidam, Luca, additional, Knol, Maria J., additional, Kochan, Nicole A., additional, Kwok, John B., additional, Leber, Markus, additional, Lam, Max, additional, Lee, Teresa, additional, Li, Shuo, additional, Loukola, Anu, additional, Luck, Tobias, additional, Marioni, Riccardo E., additional, Mather, Karen A., additional, Medland, Sarah, additional, Mirza, Saira S., additional, Nalls, Mike A., additional, Nho, Kwangsik, additional, O’Donnell, Adrienne, additional, Oldmeadow, Christopher, additional, Painter, Jodie, additional, Pattie, Alison, additional, Reppermund, Simone, additional, Risacher, Shannon L., additional, Rose, Richard J., additional, Sadashivaiah, Vijay, additional, Scholz, Markus, additional, Satizabal, Claudia L., additional, Schofield, Peter W., additional, Schraut, Katharina E., additional, Scott, Rodney J., additional, Simino, Jeannette, additional, Smith, Albert V., additional, Smith, Jennifer A., additional, Stott, David J., additional, Surakka, Ida, additional, Teumer, Alexander, additional, Thalamuthu, Anbupalam, additional, Trompet, Stella, additional, Turner, Stephen T., additional, van der Lee, Sven J., additional, Villringer, Arno, additional, Völker, Uwe, additional, Wilson, Robert S., additional, Wittfeld, Katharina, additional, Vuoksimaa, Eero, additional, Xia, Rui, additional, Yaffe, Kristine, additional, Yu, Lei, additional, Zare, Habil, additional, Zhao, Wei, additional, Ames, David, additional, Attia, John, additional, Bennett, David A., additional, Brodaty, Henry, additional, Chasman, Daniel I., additional, Goldman, Aaron L., additional, Hayward, Caroline, additional, Ikram, M. Arfan, additional, Jukema, J. Wouter, additional, Kardia, Sharon L. R., additional, Lencz, Todd, additional, Loeffler, Markus, additional, Mattay, Venkata S., additional, Palotie, Aarno, additional, Psaty, Bruce M., additional, Ramirez, Alfredo, additional, Ridker, Paul M., additional, Riedel-Heller, Steffi G., additional, Sachdev, Perminder S., additional, Saykin, Andrew J., additional, Scherer, Martin, additional, Schofield, Peter R., additional, Sidney, Stephen, additional, Starr, John M., additional, Trollor, Julian, additional, Ulrich, William, additional, Wagner, Michael, additional, Weir, David R., additional, Wilson, James F., additional, Wright, Margaret J., additional, Weinberger, Daniel R., additional, Debette, Stephanie, additional, Eriksson, Johan G., additional, Mosley, Thomas H., additional, Launer, Lenore J., additional, van Duijn, Cornelia M., additional, Deary, Ian J., additional, Seshadri, Sudha, additional, and Räikkönen, Katri, additional

Published
2022
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21. Rare genetic variants explain missing heritability in smoking

Author

Jang, Seon-Kyeong, primary, Evans, Luke, additional, Fialkowski, Allison, additional, Arnett, Donna K., additional, Ashley-Koch, Allison E., additional, Barnes, Kathleen C., additional, Becker, Diane M., additional, Bis, Joshua C., additional, Blangero, John, additional, Bleecker, Eugene R., additional, Boorgula, Meher Preethi, additional, Bowden, Donald W., additional, Brody, Jennifer A., additional, Cade, Brian E., additional, Jenkins, Brenda W. Campbell, additional, Carson, April P., additional, Chavan, Sameer, additional, Cupples, L. Adrienne, additional, Custer, Brian, additional, Damrauer, Scott M., additional, David, Sean P., additional, de Andrade, Mariza, additional, Dinardo, Carla L., additional, Fingerlin, Tasha E., additional, Fornage, Myriam, additional, Freedman, Barry I., additional, Garrett, Melanie E., additional, Gharib, Sina A., additional, Glahn, David C., additional, Haessler, Jeffrey, additional, Heckbert, Susan R., additional, Hokanson, John E., additional, Hou, Lifang, additional, Hwang, Shih-Jen, additional, Hyman, Matthew C., additional, Judy, Renae, additional, Justice, Anne E., additional, Kaplan, Robert C., additional, Kardia, Sharon L. R., additional, Kelly, Shannon, additional, Kim, Wonji, additional, Kooperberg, Charles, additional, Levy, Daniel, additional, Lloyd-Jones, Donald M., additional, Loos, Ruth J. F., additional, Manichaikul, Ani W., additional, Gladwin, Mark T., additional, Martin, Lisa Warsinger, additional, Nouraie, Mehdi, additional, Melander, Olle, additional, Meyers, Deborah A., additional, Montgomery, Courtney G., additional, North, Kari E., additional, Oelsner, Elizabeth C., additional, Palmer, Nicholette D., additional, Payton, Marinelle, additional, Peljto, Anna L., additional, Peyser, Patricia A., additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Qiao, Dandi, additional, Rader, Daniel J., additional, Rafaels, Nicholas, additional, Redline, Susan, additional, Reed, Robert M., additional, Reiner, Alexander P., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Schwartz, David A., additional, Shadyab, Aladdin H., additional, Silverman, Edwin K., additional, Smith, Nicholas L., additional, Smith, J. Gustav, additional, Smith, Albert V., additional, Smith, Jennifer A., additional, Tang, Weihong, additional, Taylor, Kent D., additional, Telen, Marilyn J., additional, Vasan, Ramachandran S., additional, Gordeuk, Victor R., additional, Wang, Zhe, additional, Wiggins, Kerri L., additional, Yanek, Lisa R., additional, Yang, Ivana V., additional, Young, Kendra A., additional, Young, Kristin L., additional, Zhang, Yingze, additional, Liu, Dajiang J., additional, Keller, Matthew C., additional, and Vrieze, Scott, additional

Published
2022
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22. Educating future scientists towards post-patrimonial governance

Author

Smith, Dorothy V.

Subjects
Cultural Studies, Original Paper, Contractualism, media_common.quotation_subject, Corporate governance, 05 social sciences, Neoliberalism, STEM education, 050401 social sciences methods, 050301 education, Face (sociological concept), Post-patrimonial governance, Environmental ethics, CONTEST, Science education, Politics, 0504 sociology, Political science, Scientists, Sociology of Education, 0503 education, media_common
Abstract

In this article, I use the idea of post-patrimonial governance to consider the science education of future scientists. I argue, with Anna Yeatman, that the politics of our time is structured by a contest between two kinds of post-patrimonial contractualism. Data are reported from a study of contemporary Australian scientists to show that some scientists are successfully conducting professional relationships with their publics that are consistent with what Yeatman has called the new contractualism. These approaches contrast with the neopatrimonial contractualism that typifies neoliberal governance and which is prevalent in many societies today. Science educators face a choice to provide accounts of science that acknowledge the work of these scientists and that prepare both future scientists and their future publics for professional relationships of reciprocal respect. I suggest approaches for school science education that are consistent with such a choice.

Published
2020
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23. Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study

Author

Törn, Carina, Liu, Xiang, Onengut-Gumuscu, Suna, Counts, Kevin M, Moreno, Jose Leonardo, Remedios, Cassandra L, Chen, Wei-Min, LeFaive, Jonathon, Butterworth, Martha D, Akolkar, Beena, Krischer, Jeffrey P, Lernmark, Åke, Rewers, Marian, She, Jin-Xiong, Toppari, Jorma, Ziegler, Anette-Gabriele, Ratan, Aakrosh, Smith, Albert V, Hagopian, William A, Rich, Stephen S, Parikh, Hemang M, TEDDY Study Group, and Apollo - University of Cambridge Repository

Subjects
Type 1 diabetes, geography, geography.geographical_feature_category, Multidisciplinary, Genotype, business.industry, Autoimmunity, Telomere, medicine.disease, Islet, medicine.disease_cause, Islets of Langerhans, Diabetes Mellitus, Type 1, Case-Control Studies, Immunology, Medicine, Humans, Female, Genetic Predisposition to Disease, business, Child, Autoantibodies
Abstract

Funder: Lund University, The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome sequencing (WGS) was performed in 1119 children in a nested case-control study design. Telomere length was estimated from WGS data using five tools: Computel, Telseq, Telomerecat, qMotif and Motif_counter. The estimated median telomere length was 5.10 kb (IQR 4.52-5.68 kb) using Computel. The age when the blood sample was drawn had a significant negative correlation with telomere length (P = 0.003). European children, particularly those from Finland (P = 0.041) and from Sweden (P = 0.001), had shorter telomeres than children from the U.S.A. Paternal age (P = 0.019) was positively associated with telomere length. First-degree relative status, presence of gestational diabetes in the mother, and maternal age did not have a significant impact on estimated telomere length. HLA-DR4/4 or HLA-DR4/X children had significantly longer telomeres compared to children with HLA-DR3/3 or HLA-DR3/9 haplogenotypes (P = 0.008). Estimated telomere length was not significantly different with respect to any IA (P = 0.377), IAA-first (P = 0.248), GADA-first (P = 0.248) or T1D (P = 0.861). These results suggest that telomere length has no major impact on the risk for IA, the first step to develop T1D. Nevertheless, telomere length was shorter in the T1D high prevalence populations, Finland and Sweden.

Published
2022

24. Selective vulnerability of tripartite synapses in amyotrophic lateral sclerosis

Author

Broadhead, Matthew J., primary, Bonthron, Calum, additional, Waddington, Julia, additional, Smith, William V., additional, Lopez, Maite F., additional, Burley, Sarah, additional, Valli, Jessica, additional, Zhu, Fei, additional, Komiyama, Noboru H., additional, Smith, Colin, additional, Grant, Seth G. N., additional, and Miles, Gareth B., additional

Published
2022
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26. Correction: Association of low-frequency and rare coding variants with information processing speed

Author

Bressler, Jan, primary, Davies, Gail, additional, Smith, Albert V., additional, Saba, Yasaman, additional, Bis, Joshua C., additional, Jian, Xueqiu, additional, Hayward, Caroline, additional, Yanek, Lisa, additional, Smith, Jennifer A., additional, Mirza, Saira S., additional, Wang, Ruiqi, additional, Adams, Hieab H. H., additional, Becker, Diane, additional, Boerwinkle, Eric, additional, Campbell, Archie, additional, Cox, Simon R., additional, Eiriksdottir, Gudny, additional, Fawns-Ritchie, Chloe, additional, Gottesman, Rebecca F., additional, Grove, Megan L., additional, Guo, Xiuqing, additional, Hofer, Edith, additional, Kardia, Sharon L. R., additional, Knol, Maria J., additional, Koini, Marisa, additional, Lopez, Oscar L., additional, Marioni, Riccardo E., additional, Nyquist, Paul, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Porteous, David J., additional, Rudan, Igor, additional, Satizabal, Claudia L., additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Sidney, Stephen, additional, Simino, Jeannette, additional, Smith, Blair H., additional, Turner, Stephen T., additional, van der Lee, Sven J., additional, Ware, Erin B., additional, Whitmer, Rachel A., additional, Yaffe, Kristine, additional, Yang, Qiong, additional, Zhao, Wei, additional, Gudnason, Vilmundur, additional, Launer, Lenore J., additional, Fitzpatrick, Annette L., additional, Psaty, Bruce M., additional, Fornage, Myriam, additional, Arfan Ikram, M., additional, van Duijn, Cornelia M., additional, Seshadri, Sudha, additional, Mosley, Thomas H., additional, and Deary, Ian J., additional

Published
2022
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30. Association of low-frequency and rare coding variants with information processing speed

Author

Bressler, Jan, primary, Davies, Gail, additional, Smith, Albert V., additional, Saba, Yasaman, additional, Bis, Joshua C., additional, Jian, Xueqiu, additional, Hayward, Caroline, additional, Yanek, Lisa, additional, Smith, Jennifer A., additional, Mirza, Saira S., additional, Wang, Ruiqi, additional, Adams, Hieab H. H., additional, Becker, Diane, additional, Boerwinkle, Eric, additional, Campbell, Archie, additional, Cox, Simon R., additional, Eiriksdottir, Gudny, additional, Fawns-Ritchie, Chloe, additional, Gottesman, Rebecca F., additional, Grove, Megan L., additional, Guo, Xiuqing, additional, Hofer, Edith, additional, Kardia, Sharon L. R., additional, Knol, Maria J., additional, Koini, Marisa, additional, Lopez, Oscar L., additional, Marioni, Riccardo E., additional, Nyquist, Paul, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Porteous, David J., additional, Rudan, Igor, additional, Satizabal, Claudia L., additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Sidney, Stephen, additional, Simino, Jeannette, additional, Smith, Blair H., additional, Turner, Stephen T., additional, van der Lee, Sven J., additional, Ware, Erin B., additional, Whitmer, Rachel A., additional, Yaffe, Kristine, additional, Yang, Qiong, additional, Zhao, Wei, additional, Gudnason, Vilmundur, additional, Launer, Lenore J., additional, Fitzpatrick, Annette L., additional, Psaty, Bruce M., additional, Fornage, Myriam, additional, Arfan Ikram, M., additional, van Duijn, Cornelia M., additional, Seshadri, Sudha, additional, Mosley, Thomas H., additional, and Deary, Ian J., additional

Published
2021
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32. Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function

Author

Yang, Tianzhong, primary, Jackson, Victoria E., additional, Smith, Albert V., additional, Chen, Han, additional, Bartz, Traci M., additional, Sitlani, Colleen M., additional, Psaty, Bruce M., additional, Gharib, Sina A., additional, O’Connor, George T., additional, Dupuis, Josée, additional, Xu, Jiayi, additional, Lohman, Kurt, additional, Liu, Yongmei, additional, Kritchevsky, Stephen B., additional, Cassano, Patricia A., additional, Flexeder, Claudia, additional, Gieger, Christian, additional, Karrasch, Stefan, additional, Peters, Annette, additional, Schulz, Holger, additional, Harris, Sarah E., additional, Starr, John M., additional, Deary, Ian J., additional, Manichaikul, Ani, additional, Oelsner, Elizabeth C., additional, Barr, R. G., additional, Taylor, Kent D., additional, Rich, Stephen S., additional, Bonten, Tobias N., additional, Mook-Kanamori, Dennis O., additional, Noordam, Raymond, additional, Li-Gao, Ruifang, additional, Jarvelin, Marjo-Riitta, additional, Wielscher, Matthias, additional, Terzikhan, Natalie, additional, Lahousse, Lies, additional, Brusselle, Guy, additional, Weiss, Stefan, additional, Ewert, Ralf, additional, Gläser, Sven, additional, Homuth, Georg, additional, Shrine, Nick, additional, Hall, Ian P., additional, Tobin, Martin, additional, London, Stephanie J., additional, Wei, Peng, additional, and Morrison, Alanna C., additional

Published
2021
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36. Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

Author

Deelen, Joris, primary, Evans, Daniel S., additional, Arking, Dan E., additional, Tesi, Niccolò, additional, Nygaard, Marianne, additional, Liu, Xiaomin, additional, Wojczynski, Mary K., additional, Biggs, Mary L., additional, van der Spek, Ashley, additional, Atzmon, Gil, additional, Ware, Erin B., additional, Sarnowski, Chloé, additional, Smith, Albert V., additional, Seppälä, Ilkka, additional, Cordell, Heather J., additional, Dose, Janina, additional, Amin, Najaf, additional, Arnold, Alice M., additional, Ayers, Kristin L., additional, Barzilai, Nir, additional, Becker, Elizabeth J., additional, Beekman, Marian, additional, Blanché, Hélène, additional, Christensen, Kaare, additional, Christiansen, Lene, additional, Collerton, Joanna C., additional, Cubaynes, Sarah, additional, Cummings, Steven R., additional, Davies, Karen, additional, Debrabant, Birgit, additional, Deleuze, Jean-François, additional, Duncan, Rachel, additional, Faul, Jessica D., additional, Franceschi, Claudio, additional, Galan, Pilar, additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Huisman, Martijn, additional, Hurme, Mikko A., additional, Jagger, Carol, additional, Jansen, Iris, additional, Jylhä, Marja, additional, Kähönen, Mika, additional, Karasik, David, additional, Kardia, Sharon L. R., additional, Kingston, Andrew, additional, Kirkwood, Thomas B. L., additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lyytikäinen, Leo-Pekka, additional, Martin-Ruiz, Carmen, additional, Min, Junxia, additional, Nebel, Almut, additional, Newman, Anne B., additional, Nie, Chao, additional, Nohr, Ellen A., additional, Orwoll, Eric S., additional, Perls, Thomas T., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Reinders, Marcel J. T., additional, Robine, Jean-Marie, additional, Rotter, Jerome I., additional, Sebastiani, Paola, additional, Smith, Jennifer, additional, Sørensen, Thorkild I. A., additional, Taylor, Kent D., additional, Uitterlinden, André G., additional, van der Flier, Wiesje, additional, van der Lee, Sven J., additional, van Duijn, Cornelia M., additional, van Heemst, Diana, additional, Vaupel, James W., additional, Weir, David, additional, Ye, Kenny, additional, Zeng, Yi, additional, Zheng, Wanlin, additional, Holstege, Henne, additional, Kiel, Douglas P., additional, Lunetta, Kathryn L., additional, Slagboom, P. Eline, additional, and Murabito, Joanne M., additional

Published
2021
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50. Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Author

Ntalla, Ioanna, primary, Weng, Lu-Chen, additional, Cartwright, James H., additional, Hall, Amelia Weber, additional, Sveinbjornsson, Gardar, additional, Tucker, Nathan R., additional, Choi, Seung Hoan, additional, Chaffin, Mark D., additional, Roselli, Carolina, additional, Barnes, Michael R., additional, Mifsud, Borbala, additional, Warren, Helen R., additional, Hayward, Caroline, additional, Marten, Jonathan, additional, Cranley, James J., additional, Concas, Maria Pina, additional, Gasparini, Paolo, additional, Boutin, Thibaud, additional, Kolcic, Ivana, additional, Polasek, Ozren, additional, Rudan, Igor, additional, Araujo, Nathalia M., additional, Lima-Costa, Maria Fernanda, additional, Ribeiro, Antonio Luiz P., additional, Souza, Renan P., additional, Tarazona-Santos, Eduardo, additional, Giedraitis, Vilmantas, additional, Ingelsson, Erik, additional, Mahajan, Anubha, additional, Morris, Andrew P., additional, Del Greco M, Fabiola, additional, Foco, Luisa, additional, Gögele, Martin, additional, Hicks, Andrew A., additional, Cook, James P., additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Sundström, Johan, additional, Nelson, Christopher P., additional, Riaz, Muhammad B., additional, Samani, Nilesh J., additional, Sinagra, Gianfranco, additional, Ulivi, Sheila, additional, Kähönen, Mika, additional, Mishra, Pashupati P., additional, Mononen, Nina, additional, Nikus, Kjell, additional, Caulfield, Mark J., additional, Dominiczak, Anna, additional, Padmanabhan, Sandosh, additional, Montasser, May E., additional, O’Connell, Jeff R., additional, Ryan, Kathleen, additional, Shuldiner, Alan R., additional, Aeschbacher, Stefanie, additional, Conen, David, additional, Risch, Lorenz, additional, Thériault, Sébastien, additional, Hutri-Kähönen, Nina, additional, Lehtimäki, Terho, additional, Lyytikäinen, Leo-Pekka, additional, Raitakari, Olli T., additional, Barnes, Catriona L. K., additional, Campbell, Harry, additional, Joshi, Peter K., additional, Wilson, James F., additional, Isaacs, Aaron, additional, Kors, Jan A., additional, van Duijn, Cornelia M., additional, Huang, Paul L., additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Launer, Lenore J., additional, Smith, Albert V., additional, Bottinger, Erwin P., additional, Loos, Ruth J. F., additional, Nadkarni, Girish N., additional, Preuss, Michael H., additional, Correa, Adolfo, additional, Mei, Hao, additional, Wilson, James, additional, Meitinger, Thomas, additional, Müller-Nurasyid, Martina, additional, Peters, Annette, additional, Waldenberger, Melanie, additional, Mangino, Massimo, additional, Spector, Timothy D., additional, Rienstra, Michiel, additional, van de Vegte, Yordi J., additional, van der Harst, Pim, additional, Verweij, Niek, additional, Kääb, Stefan, additional, Schramm, Katharina, additional, Sinner, Moritz F., additional, Strauch, Konstantin, additional, Cutler, Michael J., additional, Fatkin, Diane, additional, London, Barry, additional, Olesen, Morten, additional, Roden, Dan M., additional, Benjamin Shoemaker, M., additional, Gustav Smith, J., additional, Biggs, Mary L., additional, Bis, Joshua C., additional, Brody, Jennifer A., additional, Psaty, Bruce M., additional, Rice, Kenneth, additional, Sotoodehnia, Nona, additional, De Grandi, Alessandro, additional, Fuchsberger, Christian, additional, Pattaro, Cristian, additional, Pramstaller, Peter P., additional, Ford, Ian, additional, Wouter Jukema, J., additional, Macfarlane, Peter W., additional, Trompet, Stella, additional, Dörr, Marcus, additional, Felix, Stephan B., additional, Völker, Uwe, additional, Weiss, Stefan, additional, Havulinna, Aki S., additional, Jula, Antti, additional, Sääksjärvi, Katri, additional, Salomaa, Veikko, additional, Guo, Xiuqing, additional, Heckbert, Susan R., additional, Lin, Henry J., additional, Rotter, Jerome I., additional, Taylor, Kent D., additional, Yao, Jie, additional, de Mutsert, Renée, additional, Maan, Arie C., additional, Mook-Kanamori, Dennis O., additional, Noordam, Raymond, additional, Cucca, Francesco, additional, Ding, Jun, additional, Lakatta, Edward G., additional, Qian, Yong, additional, Tarasov, Kirill V., additional, Levy, Daniel, additional, Lin, Honghuang, additional, Newton-Cheh, Christopher H., additional, Lunetta, Kathryn L., additional, Murray, Alison D., additional, Porteous, David J., additional, Smith, Blair H., additional, Stricker, Bruno H., additional, Uitterlinden, André, additional, van den Berg, Marten E., additional, Haessler, Jeffrey, additional, Jackson, Rebecca D., additional, Kooperberg, Charles, additional, Peters, Ulrike, additional, Reiner, Alexander P., additional, Whitsel, Eric A., additional, Alonso, Alvaro, additional, Arking, Dan E., additional, Boerwinkle, Eric, additional, Ehret, Georg B., additional, Soliman, Elsayed Z., additional, Avery, Christy L., additional, Gogarten, Stephanie M., additional, Kerr, Kathleen F., additional, Laurie, Cathy C., additional, Seyerle, Amanda A., additional, Stilp, Adrienne, additional, Assa, Solmaz, additional, Abdullah Said, M., additional, Yldau van der Ende, M., additional, Lambiase, Pier D., additional, Orini, Michele, additional, Ramirez, Julia, additional, Van Duijvenboden, Stefan, additional, Arnar, David O., additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Sulem, Patrick, additional, Thorleifsson, Gudmar, additional, Thorolfsdottir, Rosa B., additional, Thorsteinsdottir, Unnur, additional, Benjamin, Emelia J., additional, Tinker, Andrew, additional, Stefansson, Kari, additional, Ellinor, Patrick T., additional, Jamshidi, Yalda, additional, Lubitz, Steven A., additional, and Munroe, Patricia B., additional

Published
2020
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