1. Response of the nuclear xenobiotic receptors to alleviate glyphosate-based herbicide-induced nephrotoxicity in weaned piglets
- Author
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Yanan Gao, Yang Liu, Shengnan Qiu, Baoming Shi, and Huiyang Fu
- Subjects
medicine.medical_specialty ,Glucuronosyltransferase ,Swine ,Health, Toxicology and Mutagenesis ,Glycine ,Xenobiotics ,Nephrotoxicity ,Superoxide dismutase ,Internal medicine ,Constitutive androstane receptor ,medicine ,Animals ,Environmental Chemistry ,Receptor ,Constitutive Androstane Receptor ,Pregnane X receptor ,biology ,Herbicides ,Chemistry ,General Medicine ,Pollution ,Endocrinology ,Catalase ,biology.protein ,Pregnenolone ,Female ,medicine.drug - Abstract
Glyphosate-based herbicides (GBHs) are widely used worldwide. Glyphosate (GLP) is the main active component of GBHs. The presence of GBH residues in the environment has led to the exposure of animals to GBHs, but the mechanisms of GBH-induced nephrotoxicity are not clear. This study investigated the effects of GBHs on piglet kidneys. Twenty-eight healthy female hybrid weaned piglets (Duroc × Landrace × Yorkshire) with an average weight of 12.24 ± 0.61 kg were randomly divided into four treatment groups (n=7 piglets/group) that were supplemented with Roundup® (equivalent to GLP concentrations of 0, 10, 20, and 40 mg/kg) for a 35-day feeding trial. The results showed that the kidneys in the 40-mg/kg GLP group suffered slight damage. Roundup® significantly decreased the activity of catalase (CAT) (P=0.005) and increased the activity of superoxide dismutase (SOD) (P=0.029). Roundup® increased the level of cystatin-C (Cys-C) in the plasma (linear, P=0.002 and quadratic, P=0.015). The levels of neutrophil gelatinase-associated lipocalin (NGAL) in plasma increased linearly (P=0.007) and quadratically (P=0.003) as the dose of GLP increased. The mRNA expression of intercellular cell adhesion molecule-1 (ICAM-1) in the 20-mg/kg GLP group was increased significantly (P
- Published
- 2021