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23 results on '"Schneider, Stefan W."'

8. Platelet adhesion and aggregate formation controlled by immobilised and soluble VWF

Author

Massachusetts Institute of Technology. Department of Materials Science and Engineering, Schneider, Matthias F., Fallah, Mohammad A., Mess, Christian, Obser, Tobias, Schneppenheim, Reinhard, Alexander-Katz, Alfredo, Schneider, Stefan W., Huck, Volker, Massachusetts Institute of Technology. Department of Materials Science and Engineering, Schneider, Matthias F., Fallah, Mohammad A., Mess, Christian, Obser, Tobias, Schneppenheim, Reinhard, Alexander-Katz, Alfredo, Schneider, Stefan W., and Huck, Volker

Abstract

Background It has been demonstrated that von Willebrand factor (VWF) mediated platelet-endothelium and platelet-platelet interactions are shear dependent. The VWF’s mobility under dynamic conditions (e.g. flow) is pivotal to platelet adhesion and VWF-mediated aggregate formation in the cascade of VWF-platelet interactions in haemostasis. Results Combining microfluidic tools with fluorescence and reflection interference contrast microscopy (RICM), here we show, that specific deletions in the A-domains of the biopolymer VWF affect both, adhesion and aggregation properties independently. Intuitively, the deletion of the A1-domain led to a significant decrease in both adhesion and aggregate formation of platelets. Nevertheless, the deletion of the A2-domain revealed a completely different picture, with a significant increase in formation of rolling aggregates (gain of function). We predict that the A2-domain effectively ‘masks’ the potential between the platelet glycoprotein (GP) Ib and the VWF A1-domain. Furthermore, the deletion of the A3-domain led to no significant variation in either of the two functional characteristics. Conclusions These data demonstrate that the macroscopic functional properties i.e. adhesion and aggregate formation cannot simply be assigned to the properties of one particular domain, but have to be explained by cooperative phenomena. The absence or presence of molecular entities likewise affects the properties (thermodynamic phenomenology) of its neighbours, therefore altering the macromolecular function.

Published
2020

9. Differences of the tumour cell glycocalyx affect binding of capsaicin-loaded chitosan nanocapsules

Author

von Palubitzki, Lydia, primary, Wang, Yuanyuan, additional, Hoffmann, Stefan, additional, Vidal-y-Sy, Sabine, additional, Zobiak, Bernd, additional, Failla, Antonio V., additional, Schmage, Petra, additional, John, Axel, additional, Osorio-Madrazo, Anayancy, additional, Bauer, Alexander T., additional, Schneider, Stefan W., additional, Goycoolea, Francisco M., additional, and Gorzelanny, Christian, additional

Published
2020
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12. Claudin-1 decrease impacts epidermal barrier function in atopic dermatitis lesions dose-dependently

Author

Bergmann, Sophia, primary, von Buenau, Barbara, additional, Vidal-y-Sy, Sabine, additional, Haftek, Marek, additional, Wladykowski, Ewa, additional, Houdek, Pia, additional, Lezius, Susanne, additional, Duplan, Hélène, additional, Bäsler, Katja, additional, Dähnhardt-Pfeiffer, Stephan, additional, Gorzelanny, Christian, additional, Schneider, Stefan W., additional, Rodriguez, Elke, additional, Stölzl, Dora, additional, Weidinger, Stephan, additional, and Brandner, Johanna M., additional

Published
2020
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13. Tight Junction barriers in human hair follicles – role of claudin-1

Author

Zorn-Kruppa, Michaela, primary, Vidal-y-Sy, Sabine, additional, Houdek, Pia, additional, Wladykowski, Ewa, additional, Grzybowski, Stephan, additional, Gruber, Robert, additional, Gorzelanny, Christian, additional, Harcup, Jason, additional, Schneider, Stefan W., additional, Majumdar, Amitabha, additional, and Brandner, Johanna M., additional

Published
2018
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14. Cellular stress induces erythrocyte assembly on intravascular von Willebrand factor strings and promotes microangiopathy

Author

Nicolay, Jan P., primary, Thorn, Verena, additional, Daniel, Christoph, additional, Amann, Kerstin, additional, Siraskar, Balasaheb, additional, Lang, Florian, additional, Hillgruber, Carina, additional, Goerge, Tobias, additional, Hoffmann, Stefan, additional, Gorzelanny, Christian, additional, Huck, Volker, additional, Mess, Christian, additional, Obser, Tobias, additional, Schneppenheim, Reinhard, additional, Fleming, Ingrid, additional, Schneider, Matthias F., additional, and Schneider, Stefan W., additional

Published
2018
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16. From morphology to biochemical state – intravital multiphoton fluorescence lifetime imaging of inflamed human skin

Author

Huck, Volker, primary, Gorzelanny, Christian, additional, Thomas, Kai, additional, Getova, Valentina, additional, Niemeyer, Verena, additional, Zens, Katharina, additional, Unnerstall, Tim R., additional, Feger, Julia S., additional, Fallah, Mohammad A., additional, Metze, Dieter, additional, Ständer, Sonja, additional, Luger, Thomas A., additional, Koenig, Karsten, additional, Mess, Christian, additional, and Schneider, Stefan W., additional

Published
2016
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17. Silver nanoparticle-enriched diamond-like carbon implant modification as a mammalian cell compatible surface with antimicrobial properties

Author

Gorzelanny, Christian, primary, Kmeth, Ralf, additional, Obermeier, Andreas, additional, Bauer, Alexander T., additional, Halter, Natalia, additional, Kümpel, Katharina, additional, Schneider, Matthias F., additional, Wixforth, Achim, additional, Gollwitzer, Hans, additional, Burgkart, Rainer, additional, Stritzker, Bernd, additional, and Schneider, Stefan W., additional

Published
2016
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