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2. Landscape level effects of invasive plants and animals on water infiltration through Hawaiian tropical forests

Author

Makani Gregg, Lucas B. Fortini, Kim S. Perkins, Christina R. Leopold, Kai’ena I Bishaw, Stephanie G. Yelenik, Oliver A. Chadwick, and James D. Jacobi

Subjects
0106 biological sciences, geography, geography.geographical_feature_category, Ungulate, Ecology, 010604 marine biology & hydrobiology, Community structure, Groundwater recharge, Biology, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Grassland, Invasive species, Ecosystem services, Infiltration (hydrology), Ecosystem, Ecology, Evolution, Behavior and Systematics
Abstract

Watershed degradation due to invasion threatens downstream water flows and associated ecosystem services. While this topic has been studied across landscapes that have undergone invasive-driven state changes (e.g., native forest to invaded grassland), it is less well understood in ecosystems experiencing within-system invasion (e.g. native forest to invaded forest). To address this subject, we conducted an integrated ecological and ecohydrological study in tropical forests impacted by invasive plants and animals. We measured soil infiltration capacity in multiple fenced (i.e., ungulate-free)/unfenced and native/invaded forest site pairs along moisture and substrate age gradients across Hawaii to explore the effects of invasion on hydrological processes within tropical forests. We also characterized forest composition, structure and soil characteristics at these sites to assess the direct and vegetation-mediated impacts of invasive species on infiltration capacity. Our models show that invasive ungulates negatively affect soil infiltration capacity consistently across the wide moisture and substrate age gradients considered. Additionally, several soil characteristics known to be affected by invasive ungulates were associated with local infiltration rates, indicating that the long-term secondary effects of high ungulate densities in tropical forests may be stronger than effects observed in this study. The effect of invasive plants on infiltration was complex and likely to depend on their physiognomy within existing forest community structure. These results provide clear evidence for managers that invasive ungulate control efforts can improve ecohydrological function of mesic and wet forest systems critical to protecting downstream and nearshore resources and maintaining groundwater recharge.

Published
2021
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3. Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

Author

null Author et al, R. M. Bateman, M. D. Sharpe, J. E. Jagger, C. G. Ellis, J. Solé-Violán, M. López-Rodríguez, E. Herrera-Ramos, J. Ruíz-Hernández, L. Borderías, J. Horcajada, N. González-Quevedo, O. Rajas, M. Briones, F. Rodríguez de Castro, C. Rodríguez Gallego, F. Esen, G. Orhun, P. Ergin Ozcan, E. Senturk, C. Ugur Yilmaz, N. Orhan, N. Arican, M. Kaya, M. Kucukerden, M. Giris, U. Akcan, S. Bilgic Gazioglu, E. Tuzun, R. Riff, O. Naamani, A. Douvdevani, R. Takegawa, H. Yoshida, T. Hirose, N. Yamamoto, H. Hagiya, M. Ojima, Y. Akeda, O. Tasaki, K. Tomono, T. Shimazu, S. Ono, T. Kubo, S. Suda, T. Ueno, T. Ikeda, H. Ogura, H. Takahashi, J. Kang, Y. Nakamura, T. Kojima, Y. Izutani, T. Taniguchi, M. O, C. Dinter, J. Lotz, B. Eilers, C. Wissmann, R. Lott, M. M. Meili, P. S. Schuetz, H. Hawa, M. Sharshir, M. Aburageila, N. Salahuddin, V. Chantziara, S. Georgiou, A. Tsimogianni, P. Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, G. Micha, E. Chinou, G. Michaloudis, A. Kodaira, H. Imaizumi, M. V. De la Torre-Prados, A. Garcia-De la Torre, A. Enguix-Armada, A. Puerto-Morlan, V. Perez-Valero, A. Garcia-Alcantara, N. Bolton, J. Dudziak, S. Bonney, A. Tridente, P. Nee, G. Nicolaes, M. Wiewel, M. Schultz, K. Wildhagen, J. Horn, R. Schrijver, T. Van der Poll, C. Reutelingsperger, S. Pillai, G. Davies, G. Mills, R. Aubrey, K. Morris, P. Williams, P. Evans, E. G. Gayat, J. Struck, A. Cariou, N. Deye, B. Guidet, S. Jabert, J. Launay, M. Legrand, M. Léone, M. Resche-Rigon, E. Vicaut, A. Vieillard-Baron, A. Mebazaa, R. Arnold, M. Capan, A. Linder, P. Akesson, M. Popescu, D. Tomescu, C. L. Sprung, R. Calderon Morales, G. Munteanu, E. Orenbuch-Harroch, P. Levin, H. Kasdan, A. Reiter, T. Volker, Y. Himmel, Y. Cohen, J. Meissonnier, L. Girard, F. Rebeaud, I. Herrmann, B. Delwarde, E. Peronnet, E. Cerrato, F. Venet, A. Lepape, T. Rimmelé, G. Monneret, J. Textoris, N. Beloborodova, V. Moroz, A. Osipov, A. Bedova, Y. Sarshor, A. Pautova, A. Sergeev, E. Chernevskaya, J. Odermatt, R. Bolliger, L. Hersberger, M. Ottiger, M. Christ-Crain, B. Mueller, P. Schuetz, N. K. Sharma, A. K. Tashima, M. K. Brunialti, F. R. Machado, M. Assuncao, O. Rigato, R. Salomao, S. C. Cajander, G. Rasmussen, E. Tina, B. Söderquist, J. Källman, K. Strålin, A. L. Lange, J. S. Sundén-Cullberg, A. M. Magnuson, O. H. Hultgren, P. Van der Geest, M. Mohseni, J. Linssen, R. De Jonge, S. Duran, J. Groeneveld, R. Miller, B. K. Lopansri, L. C. McHugh, A. Seldon, J. P. Burke, J. Johnston, R. Reece-Anthony, A. Bond, A. Molokhia, C. Mcgrath, E. Nsutebu, P. Bank Pedersen, D. Pilsgaard Henriksen, S. Mikkelsen, A. Touborg Lassen, R. Tincu, C. Cobilinschi, Z. Ghiorghiu, R. Macovei, M. A. Wiewel, M. B. Harmon, L. A. Van Vught, B. P. Scicluna, A. J. Hoogendijk, A. H. Zwinderman, O. L. Cremer, M. J. Bonten, M. J. Schultz, N. P. Juffermans, W. J. Wiersinga, G. Eren, Y. Tekdos, M. Dogan, O. Acicbe, E. Kaya, O. Hergunsel, S. Alsolamy, G. Ghamdi, L. Alswaidan, S. Alharbi, F. Alenezi, Y. Arabi, J. Heaton, A. Boyce, L. Nolan, A. Dukoff-Gordon, A. Dean, T. Mann Ben Yehudah, C. Fleischmann, D. Thomas-Rueddel, C. Haas, U. Dennler, K. Reinhart, O. Suntornlohanakul, B. Khwannimit, F. Breckenridge, A. Puxty, P. Szturz, P. Folwarzcny, J. Svancara, R. Kula, P. Sevcik, L. Caneva, A. Casazza, E. Bellazzi, S. Marra, L. Pagani, M. Vetere, R. Vanzino, D. Ciprandi, R. Preda, R. Boschi, L. Carnevale, V. Lopez, M. Aguilar Arzapalo, L. Barradas, A. Escalante, J. Gongora, M. Cetina, B Adamik, D Jakubczyk, A Kübler, A. Radford, T. Lee, J. Singer, J. Boyd, D. Fineberg, M. Williams, J. Russell, E. Scarlatescu, G. Droc, S. Arama, M. Müller, M. Straat, S. S. Zeerleder, C. F. Fuchs, C. S. Scheer, S. W. Wauschkuhn, M. V. Vollmer, K. M. Meissner, S. K. Kuhn, K. H. Hahnenkamp, S. R. Rehberg, M. G. Gründling, S. Hamaguchi, E. Gómez-Sánchez, M. Heredia-Rodríguez, E. Álvarez-Fuente, M. Lorenzo-López, E. Gómez-Pesquera, M. Aragón-Camino, P. Liu-Zhu, A. Sánchez-López, A. Hernández-Lozano, M. T. Peláez-Jareño, E. Tamayo, D. O. Thomas-Rüddel, V. Adora, A. Kar, A. Chakraborty, S. Roy, A. Bandyopadhyay, M. Das, G. BenYehudah, M. Salim, N. Kumar, L. Arabi, T. Burger, P. Lephart, E. Toth-martin, C. Valencia, N. Hammami, S. Blot, J. L. Vincent, M. L. Lambert, J. Brunke, T. Riemann, I. Roschke, S. Nimitvilai, K. Jintanapramote, S. Jarupongprapa, D. Adukauskiene, D. Valanciene, G. Bose, V. Lostarakos, B. Carr, S. Khedher, A. Maaoui, A. Ezzamouri, M. Salem, J. Chen, D. R. Cranendonk, M. Day, G. Penrice, K. Roy, P. Robertson, G. Godbole, B. Jones, M. Booth, L. Donaldson, Y. Kawano, H. Ishikura, H. Al-Dorzi, M. Almutairi, B. Alhamadi, A. Crizaldo Toledo, R. Khan, B. Al Raiy, H. Talaie, J. A. Van Oers, A. Harts, E. Nieuwkoop, P. Vos, Y. Boussarsar, F. Boutouta, S. Kamoun, I. Mezghani, S. Koubaji, A. Ben Souissi, A. Riahi, M. S. Mebazaa, E. Giamarellos-Bourboulis, N. Tziolos, C. Routsi, C. Katsenos, I. Tsangaris, I. Pneumatikos, G. Vlachogiannis, V. Theodorou, A. Prekates, E. Antypa, V. Koulouras, N. Kapravelos, C. Gogos, E. Antoniadou, K. Mandragos, A. Armaganidis, A. R. Robles Caballero, B. Civantos, J. C. Figueira, J. López, A. Silva-Pinto, F. Ceia, A. Sarmento, L. Santos, G. Almekhlafi, Y. Sakr, S. Baharoon, A. Aldawood, A. Matroud, J. Alchin, S. Al Johani, H. Balkhy, S. Y. Yousif, B. O. Alotabi, A. S. Alsaawi, J. Ang, M. D. Curran, D. Enoch, V. Navapurkar, A. Morris, R. Sharvill, J. Astin, J. Patel, C. Kruger, J. O’Neal, H. Rhodes, J. Jancik, B. François, P. F. Laterre, P. Eggimann, A. Torres, M. Sánchez, P. F. Dequin, G. L. Bassi, J. Chastre, H. S. Jafri, M. Ben Romdhane, Z. Douira, M. Bousselmi, A. Vakalos, V. Avramidis, T. H. Craven, G. Wojcik, K. Kefala, J. McCoubrey, J. Reilly, R. Paterson, D. Inverarity, I. Laurenson, T. S. Walsh, S. Mongodi, B. Bouhemad, A. Orlando, A. Stella, G. Via, G. Iotti, A. Braschi, F. Mojoli, M. Haliloglu, B. Bilgili, U. Kasapoglu, I. Sayan, M. Süzer Aslan, A. Yalcin, I. Cinel, H. E. Ellis, K. Bauchmuller, D. Miller, A. Temple, C. E. Luyt, M. Singer, Y. Nassar, M. S. Ayad, A. Trifi, S. Abdellatif, F. Daly, R. Nasri, S. Ben Lakhal, F. Gul, A. Kuzovlev, A. Shabanov, S. Polovnikov, N. Kadrichu, T. Dang, K. Corkery, P. Challoner, G. Li Bassi, E. Aguilera, C. Chiurazzi, C. Travierso, A. Motos, L. Fernandez, R. Amaro, T. Senussi, F. Idone, J. Bobi, M. Rigol, C. J. Hodiamont, J. M. Janssen, C. S. Bouman, R. A. Mathôt, M. D. De Jong, R. M. Van Hest, L. Payne, G. L. Fraser, B. Tudor, M. Lahner, G. Roth, C. Krenn, P. Jault, J. Gabard, T. Leclerc, S. Jennes, Y. Que, A. Rousseau, F. Ravat, A. Eissa, S. Al-Harbi, T. Aldabbagh, S. Abdellatif., F. Paramba, N. Purayil, V. Naushad, O. Mohammad, V. Negi, P. Chandra, A. Kleinsasser, M. R. Witrz, J. F. Buchner-Doeven, A. M. Tuip-de Boer, J. C. Goslings, M. Van Hezel, A Boing, R Van Bruggen, N Juffermans, D. Markopoulou, K. Venetsanou, V. Kaldis, D. Koutete, D. Chroni, I. Alamanos, L. Koch, E. Walter, K. Maekawa, M. Hayakawa, S. Kushimoto, A. Shiraishi, H. Kato, J. Sasaki, T. Matauoka, T. Uejima, N. Morimura, A. Hagiwara, M. Takeda, O. Tarabrin, S. Shcherbakow, D. Gavrychenko, G. Mazurenko, V. Ivanova, O. Chystikov, C. Plourde, J. Lessard, J. Chauny, R. Daoust, L. Kropman, L. In het Panhuis, J. Konings, D. Huskens, E. Schurgers, M. Roest, B. De Laat, M. Lance, M. Durila, P. Lukas, M. Astraverkhava, J. Jonas, I. Budnik, B. Shenkman, H. Hayami, Y. Koide, T. Goto, R. Iqbal, Y. Alhamdi, N. Venugopal, S. Abrams, C. Downey, C. H. Toh, I. D. Welters, V. B. Bombay, J. M. Chauny, R. D. Daoust, J. L. Lessard, M. M. Marquis, J. P. Paquet, K. Siemens, D. Sangaran, B. J. Hunt, A. Durward, A. Nyman, I. A. Murdoch, S. M. Tibby, F. Ampatzidou, D. Moisidou, E. Dalampini, M. Nastou, E. Vasilarou, V. Kalaizi, H. Chatzikostenoglou, G. Drossos, S. Spadaro, A. Fogagnolo, T. Fiore, A. Schiavi, V. Fontana, F. Taccone, C. Volta, E. Chochliourou, E. Volakli, A. Violaki, E. Samkinidou, G. Evlavis, V. Panagiotidou, M. Sdougka, R. Mothukuri, C. Battle, K. Guy, J. Wijesuriya, S. Keogh, A. Docherty, R. O’Donnell, S. Brunskill, M. Trivella, C. Doree, L. Holst, M. Parker, M. Gregersen, J. Almeida, T. Walsh, S. Stanworth, S. Moravcova, J. Mansell, A. Rogers, R. A. Smith, C. Hamilton-Davies, A. Omar, M. Allam, O. Bilala, A. Kindawi, H. Ewila, A. Malamas, G. Ferreira, J. Caldas, J. Fukushima, E. A. Osawa, E. Arita, L. Camara, S. Zeferino, J. Jardim, F. Gaioto, L. Dallan, F. B. Jatene, R. Kalil Filho, F. Galas, L. A. Hajjar, C. Mitaka, T. Ohnuma, T. Murayama, F. Kunimoto, M. Nagashima, T. Takei, M. Tomita, K. Mahmoud, S. Hanoura, S. Sudarsanan, P. Sivadasan, H. Othamn, Y. Shouman, R. Singh, A. Al Khulaifi, I. Mandel, S. Mikheev, I. Suhodolo, V. Kiselev, Y. Svirko, Y. Podoksenov, S. A. Jenkins, R. Griffin, M. S. Tovar Doncel, A. Lima, C. Aldecoa, C. Ince, A. Taha, A. Shafie, M. Mostafa, N. Syed, H. Hon, F. Righetti, E. Colombaroli, G. Castellano, M. Hravnak, L. C. Chen, A. D. Dubrawski, G. C. Clermont, M. R. Pinsky, S. Gonzalez, D. Macias, J. Acosta, P. Jimenez, A. Loza, A. Lesmes, F. Lucena, C. Leon, M. Bastide, J. Richecoeur, E. Frenoy, C. Lemaire, B. Sauneuf, F. Tamion, S. Nseir, D. Du Cheyron, H. Dupont, J. Maizel, M. Shaban, R. Kolko, M. AbuRageila, A. AlHussain, P. Mercado, L. Kontar, D. Titeca, F. Brazier, A. Riviere, M. Joris, T. Soupison, B. De Cagny, M. Slama, J. Wagner, A. Körner, M. Kubik, S. Kluge, D. Reuter, B. Saugel, T. Tran, D. De Bels, A. Cudia, M. Strachinaru, P. Ghottignies, J. Devriendt, C. Pierrakos, Ó. Martínez González, R. Blancas, J. Luján, D. Ballesteros, C. Martínez Díaz, A. Núñez, C. Martín Parra, B. López Matamala, M. Alonso Fernández, M. Chana, W. Huber, M. Eckmann, F. Elkmann, A. Gruber, I. Klein, R. M. Schmid, T. Lahmer, P. W. Moller, S. Sondergaard, S. M. Jakob, J. Takala, D. Berger, D. Bastoni, H. Aya, L. Toscani, L. Pigozzi, A. Rhodes, M. Cecconi, C. Ostrowska, A. Abbas, J. Mellinghoff, C. Ryan, D. Dawson, M. Cronhjort, O. Wall, E. Nyberg, R. Zeng, C. Svensen, J. Mårtensson, E. Joelsson-Alm, N. Parenti, C. Palazzi, L. A. Amidei, F. B. Borrelli, S. C. Campanale, F. T. Tagliazucchi, G. S. Sedoni, D. L. Lucchesi, E. C. Carella, A. L Luciani, M. Mackovic, N. Maric, M. Bakula, R. M. Grounds, N. Fletcher, B. Avard, P. Zhang, M. Mezidi, J. Charbit, M. Ould-Chikh, P. Deras, C. Maury, O. Martinez, X. Capdevila, P. Hou, W. Z. Linde-Zwirble, I. D. Douglas, N. S. Shapiro, Y. Ben Aicha, B. Laribi, B. Jeribi, C. Pereira, R. Marinho, R. Antunes, A. Marinho, M. Crivits, M. Raes, J. Decruyenaere, E. Hoste, V. Bagin, V. Rudnov, A. Savitsky, M. Astafyeva, I. Korobko, V. Vein, T. Kampmeier, P. Arnemann, M. Hessler, A. Wald, K. Bockbreder, A. Morelli, H. Van Aken, S. Rehberg, C. Ertmer, S. Reddy, M. Bailey, R. Beasley, R. Bellomo, D. Mackle, A. Psirides, P. Young, H. Venkatesh, S. Ramachandran, A. Basu, H. Nair, S. Egan, J. Bates, S. Oliveira, N. R. Rangel Neto, F. Q. Reis, C. P. Lee, X. L. Lin, C. Choong, K. M. Eu, W. Y. Sim, K. S. Tee, J. Pau, J. Abisheganaden, K. Maas, H. De Geus, E. Lafuente, J. Moura, T. E. Doris, D. Monkhouse, T. Shipley, S. Kardasz, I Gonzalez, S. Stads, A. J. Groeneveld, I. Elsayed, N. Ward, A. Raithatha, A. Steuber, C. Pelletier, S. Schroeder, E. Michael, T. Slowinski, D. Kindgen-Milles, S. Ghabina, F. Turani, A. Belli, S. Busatti, G. Barettin, F. Candidi, F. Gargano, R. Barchetta, M. Falco, O. Demirkiran, M. Kosuk, S. Bozbay, V. Weber, J. Hartmann, S. Harm, I. Linsberger, T. Eichhorn, G. Valicek, G. Miestinger, C. Hoermann, S. Faenza, D. Ricci, E. Mancini, C. Gemelli, A. Cuoghi, S. Magnani, M. Atti, T. Laddomada, A. Doronzio, B. Balicco, M. C. Gruda, P. O’Sullivan, V. P. Dan, T. Guliashvili, A. Scheirer, T. D. Golobish, V. J. Capponi, P. P. Chan, K. Kogelmann, M. Drüner, D. Jarczak, A. B. Belli, S. M. Martni, V. C. Cotticelli, F. Mounajergi, S. Morimoto, I. Hussain, A. Nadeem, K. Ghorab, K. Maghrabi, S. K. Kloesel, C. Goldfuss, A. Stieglitz, A. S. Stieglitz, L. Krstevska, G. Albuszies, G. Jimmy, J. Izawa, T. Iwami, S. Uchino, M. Takinami, T. Kitamura, T. Kawamura, J. G. Powell-Tuck, S. Crichton, M. Raimundo, L. Camporota, D. Wyncoll, M. Ostermann, A. Hana, H. R. De Geus, M. Aydogdu, N. Boyaci, S. Yuksel, G. Gursel, A. B. Cayci Sivri, J. Meza-Márquez, J. Nava-López, R. Carrillo-Esper, A. Dardashti, A. Grubb, M. Wetzstein, E. Peters, H. Njimi, P. Pickkers, M. Waraich, J. Doyle, T. Samuels, L. Forni, N. Desai, R. Baumber, P. Gunning, A. Sell, S. Lin, H. Torrence, M. O’Dwyer, C. Kirwan, J. Prowle, T. Kim, M. E. O’Connor, R. W. Hewson, C. J. Kirwan, R. M. Pearse, M. Maksoud, O. Uzundere, D. Memis, M. Ýnal, A. Gultekin, N. Turan, M. A. Aydin, H. Basar, I. Sencan, A. Kapuagasi, M. Ozturk, Z. Uzundurukan, D. Gokmen, A. Ozcan, C. Kaymak, V. A. Artemenko, A. Budnyuk, R. Pugh, S. Bhandari, T. Mauri, C. Turrini, T. Langer, P. Taccone, C. A. Volta, C. Marenghi, L. Gattinoni, A. Pesenti, L. Sweeney, A. O’Sullivan, P. Kelly, E. Mukeria, R. MacLoughlin, M. Pfeffer, J. T. Thomas, G. B. Bregman, G. K. Karp, E. K. Kishinevsky, D. S. Stavi, N. A. Adi, T. Poropat, R. Knafelj, E. Llopart, M. Batlle, C. De Haro, J. Mesquida, A. Artigas, D. Pavlovic, L. Lewerentz, A. Spassov, R. Schneider, S. De Smet, S. De Raedt, E. Derom, P Depuydt, S. Oeyen, D. Benoit, A. Gobatto, B. Besen, P. Tierno, L. Melro, P. Mendes, F. Cadamuro, M. Park, L. M. Malbouisson, B. C. Civantos, J. L. Lopez, A. Robles, J. Figueira, S. Yus, A. Garcia, A. Oglinda, G. Ciobanu, C. Oglinda, L. Schirca, T. Sertinean, V. Lupu, M. Wolny, A. Pagano, F. Numis, G. Visone, L. Saldamarco, T. Russo, G. Porta, F. Paladino, C. Bell, J. Liu, J. Debacker, C. Lee, E. Tamberg, V. Campbell, S. Mehta, Ý. Kara, F. Yýldýrým, A. Zerman, Z. Güllü, N. Boyacý, B. Basarýk Aydogan, Ü. Gaygýsýz, K. Gönderen, G. Arýk, M. Turkoglu, G. Aygencel, Z. Ülger, Z. Isýkdogan, Ö. Özdedeoglu, M. Badoglu, U. Gaygýsýz, N. Kongpolprom, C. Sittipunt, A. Eden, Y. Kokhanovsky, S. Bursztein – De Myttenaere, R. Pizov, L. Neilans, N. MacIntyre, M. Radosevich, B. Wanta, T. Meyer, N. Smischney, D. Brown, D. Diedrich, A. Fuller, P. McLindon, K. Sim, M. Shoaeir, K. Noeam, A. Mahrous, R. Matsa, A. Ali, C. Dridi, F. Haddad, A. Pérez-Calatayud, A. Zepeda-Mendoza, M. Diaz-Carrillo, E. Arch-Tirado, S. Carbognin, L. Pelacani, F. Zannoni, A. Agnoli, G. Gagliardi, R. Cho, A. Adams, S. Lunos, S. Ambur, R. Shapiro, M. Prekker, M. Thijssen, L. Janssen, N. Foudraine, C. J. Voscopoulos, J. Freeman, E. George, D. Eversole, S. Muttini, R. Bigi, G. Villani, N. Patroniti, G. Williams, E George, A. Waldmann, S. Böhm, W. Windisch, S. Strassmann, C. Karagiannidis, C. K. Karagiannidis, A. W. Waldmann, S. B. Böhm, W. W. Windisch, P. Persson, S. Lundin, O. Stenqvist, C. S. Serra, A. P. Pagano, M. M. Masarone, L. R. Rinaldi, A. A. Amelia, M. F. Fascione, L. A. Adinolfi, E. R. Ruggiero, F. Asota, K. O’Rourke, S. Ranjan, P. Morgan, J. W. DeBacker, L. O’Neill, L. Munshi, L. Burry, E. Fan, S. Poo, K. Mahendran, J. Fowles, C. Gerrard, A. Vuylsteke, R. Loveridge, C. Chaddock, S. Patel, V. Kakar, C. Willars, T. Hurst, C. Park, T. Best, A. Vercueil, G. Auzinger, A. Borgman, A. G. Proudfoot, E. Grins, K. E. Emiley, J. Schuitema, S. J. Fitch, G. Marco, J. Sturgill, M. G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge, C. Sampson, S. Harris-Fox, M. E. Cove, L. H. Vu, A. Sen, W. J. Federspiel, J. A. Kellum, C. Mazo Torre, J. Riera, S. Ramirez, B. Borgatta, L. Lagunes, J. Rello, A. K. Kuzovlev, A. Goloubev, S. Nenchuk, V. Karavana, C. Glynos, A. Asimakos, K. Pappas, C. Vrettou, M. Magkou, E. Ischaki, G. Stathopoulos, S. Zakynthinos, I. Kozhevnikova, F. Dalla Corte, S. Grasso, P. Casolari, G. Caramori, T. Andrianjafiarinoa, T. Randriamandrato, T. Rajaonera, S. El-Dash, E. L. V. Costa, M. R. Tucci, F Leleu, L Kontar, G. Bacari-Risal, M. Amato, S. El Dash, null Remmington, A. Fischer, S. Squire, M. Boichat, H. Honzawa, H. Yasuda, T. Adati, S. Suzaki, M. Horibe, M. Sasaki, M. Sanui, J. Daniel, H. Miranda, K. Milinis, M. Cooper, G. R. Williams, E. McCarron, S. Simants, I. Patanwala, I. Welters, Y. Su, J. Fernández Villanueva, R. Fernández Garda, A. López Lago, E. Rodríguez Ruíz, R. Hernández Vaquero, S. Tomé Martínez de Rituerto, E. Varo Pérez, N. Lefel, F. Schaap, D. Bergmans, S. Olde Damink, M. Van de Poll, K. Tizard, C. Lister, L. Poole, D. Ringaitiene, D. Gineityte, V. Vicka, I. Norkiene, J. Sipylaite, A. O’Loughlin, V. Maraj, J. Dowling, M. B. Velasco, D. M. Dalcomune, E. B. Dias, S. L. Fernandes, T. Oshima, S. Graf, C. Heidegger, L. Genton, V. Karsegard, Y. Dupertuis, C. Pichard, N. Friedli, Z. Stanga, L. Vandersteen, B. Stessel, S. Evers, A. Van Assche, L. Jamaer, J. Dubois, H. Castro, J. Valente, P. Martins, P. Casteloes, C. Magalhaes, S. Cabral, M. Santos, B. Oliveira, A. Salgueiro, S. Duarte, S. Castro, M. Melo, S. Gray, K. Maipang, R. Bhurayanontachai, L. G. Grädel, P. Schütz, P. Langlois, W. Manzanares, M. Lemieux, G. Elke, F. Bloos, D. Heyland, I. Aramendi, N. Babo, M. Hoshino, Y. Haraguchi, S. Kajiwara, T. Mitsuhashi, T. Tsubata, M. Aida, T. Rattanapraphat, C. Kongkamol, B. Xavier, C. Koutsogiannidis, M. Moschopoulou, G. Taskin, M. Çakir, AK Güler, A. Taskin, N. Öcal, S. Özer, L. Yamanel, J. M. Wong, C. Fitton, S. Anwar, S. Stacey, M. Aggou, B. Fyntanidou, S. Patsatzakis, E. Oloktsidou, K. Lolakos, E. Papapostolou, V. Grosomanidis, S. Gaudry, V. Desailly, P. Pasquier, PB Brun, AT Tesnieres, JD Ricard, D. Dreyfuss, A. Mignon, J. C White, A. Stilwell, G. Friedlaender, M. Peters, S. Stipulante, A. Delfosse, AF Donneau, A. Ghuysen, C. Feldmann, D. Freitag, W. Dersch, M. Irqsusi, D. Eschbach, T. Steinfeldt, H. Wulf, T. Wiesmann, J. Cholkraisuwat, S. Beitland, E. Nakstad, H. Stær-Jensen, T. Drægni, G. Andersen, D. Jacobsen, C. Brunborg, B. Waldum-Grevbo, K. Sunde, K. Hoyland, D. Pandit, K. Hayakawa, K. Kotzampassi, L. Loukipoudi, E. Doumaki, M. M. Admiraal, M. Van Assen, M. J. Van Putten, M. Tjepkema-Cloostermans, A. F. Van Rootselaar, F. Ragusa, A. Marudi, S. Baroni, A. Gaspari, E. Bertellini, T. Abdullah, S. Abdel Monem, S. Alcorn, S. McNeill, S. Russell, W. Eertmans, C. Genbrugge, I. Meex, J. Dens, F. Jans, C. De Deyne, B Avard, R Burns, A. Patarchi, T. Spina, H. Tanaka, N. Otani, S. Ode, S. Ishimatsu, J. Cho, J. B. Moon, C. W. Park, T. G. Ohk, M. C. Shin, M. H. Won, S. Dakova, Z. Ramsheva, K. Ramshev, A Marudi, S Baroni, A Gaspari, E Bertellini, P. E. Ozcan, S. Sencer, C. Ulusoy, M. Fallenius, M. B. Skrifvars, M. Reinikainen, S. Bendel, R. Raj, M. Abu-Habsa, C. Hymers, A. Borowska, H. Sivadhas, S. Sahiba, S. Perkins, J. Rubio, J. A. Rubio, R. Sierra, S. English, M. Chasse, A. Turgeon, F. Lauzier, D. Griesdale, A. Garland, D. Fergusson, R. Zarychanski, A. Tinmouth, C. Van Walraven, K. Montroy, J. Ziegler, R. Dupont Chouinard, R. Carignan, A. Dhaliwal, C. Lum, J. Sinclair, G. Pagliarello, L. McIntyre, T. Groza, N. Moreau, D. Castanares-Zapatero, P. Hantson, M. Carbonara, F. Ortolano, T. Zoerle, S. Magnoni, S. Pifferi, V. Conte, N. Stocchetti, L. Carteron, T. Suys, C. Patet, H. Quintard, M. Oddo, V. Spatenkova, E. Pokorna, P. Suchomel, N. Ebert, T. Bylinski, C. Hawthorne, M. Shaw, I. Piper, J. Kinsella, A. K. Kink, I. R. Rätsep, A. Boutin, L. Moore, J. Lacroix, P. Lessard-Bonaventure, A. F. Turgeon, R. Green, M. Erdogan, M. Butler, P. Desjardins, D. A. Fergusson, B. Goncalves, B. Vidal, C. Valdez, A. C. Rodrigues, L. Miguez, G. Moralez, T. Hong, A. Kutz, P. Hausfater, D. Amin, T. Struja, S. Haubitz, A. Huber, T. Brown, J. Collinson, C. Pritchett, T. Slade, M. Le Guen, S. Hellings, R. Ramsaran, A. Alsheikhly, T. Abe, L. Kanapeckaite, R. Bahl, M. Q. Russell, K. J. Real, R. M. Lyon, N. P. Oveland, J. Penketh, M. Mcdonald, F. Kelly, M. Alfafi, W. Almutairi, B. Alotaibi, A. E Van den Berg, Y. Schriel, L. Dawson, I. A. Meynaar, D. Silva, S. Fernandes, J. Gouveia, J. Santos Silva, J. Foley, A. Kaskovagheorgescu, D. Evoy, J. Cronin, J. Ryan, M. Huck, C. Hoffmann, J. Renner, P. Laitselart, N. Donat, A. Cirodde, J. V. Schaal, Y. Masson, A. Nau, O. Howarth, K. Davenport, P. Jeanrenaud, S. Raftery, P. MacTavish, H. Devine, J. McPeake, M. Daniel, T. Quasim, S. Alrabiee, A. Alrashid, O. Gundogan, C. Bor, E. Akýn Korhan, K. Demirag, M. Uyar, F. Frame, C. Ashton, L. Bergstrom Niska, P. Dilokpattanamongkol, T. Suansanae, C. Suthisisang, S. Morakul, C. Karnjanarachata, V. Tangsujaritvijit, S. Mahmood, H. Al Thani, A. Almenyar, S. E. Morton, Y. S. Chiew, C. Pretty, J. G. Chase, G. M. Shaw, P. Kordis, V. Grover, I. Kuchyn, K. Bielka, Z. Aidoni, G. Stavrou, C. Skourtis, S. D. Lee, K. Williams, I. D. Weltes, S. Berhane, C. Arrowsmith, C. Peters, S. Robert, R. B. Panerai, T. G. Robinson, E. Borg-Seng-Shu, M. De Lima Oliveira, N. C. Mian, R. Nogueira, S. P. Zeferino, M. Jacobsen Teixeira, P. Killeen, M. McPhail, W. Bernal, J. Maggs, J. Wendon, T. Hughes, L. U. Taniguchi, E. M. Siqueira, J. M. Vieira Jr, L. C. Azevedo, A. N. Ahmad, E. Helme, S. Hadfield, J. Shak, C. Senver, R. Howard-Griffin, P. Wacharasint, P. Fuengfoo, N. Sukcharoen, R. Rangsin, D. Sbiti-Rohr, H. Na, S. Song, S. Lee, E. Jeong, K. Lee, E. Zoumpelouli, E. A Volakli, V. Chrysohoidou, K. Charisopoulou, E. Kotzapanagiotou, K. Manavidou, Z. Stathi, B. AlGhamdi, Q. Marashly, K. Zaza, M. Khurshid, Z. Ali, M. Malgapo, M. Jamil, A. Shafquat, M. Shoukri, M. Hijazi, F. A. Rocha, K. Ebecken, L. S. Rabello, M. F. Lima, R. Hatum, F. V. De Marco, A. Alves, J. E. Pinto, M. Godoy, P. E. Brasil, F. A. Bozza, J. I. Salluh, M. Soares, J. Krinsley, G. Kang, J. Perry, H. Hines, K. M. Wilkinson, C. Tordoff, B. Sloan, M. C. Bellamy, E. Moreira, F. Verga, M. Barbato, G. Burghi, M Soares, U. V. Silva, A. P. Torelly, J. M. Kahn, D. C. Angus, M. F. Knibel, R. Marshall, T. Gilpin, D. Mota, B. Loureiro, J. Dias, O. Afonso, F. Coelho, A. Martins, F. Faria, H. Al Orainni, F. AlEid, H. Tlaygeh, A. Itani, A. Hejazi, J. Messika, J. D. Ricard, S. Guillo, B. Pasquet, E. Dubief, F. Tubach, K. James, P. Temblett, L. Davies, C. Lynch, S. Pereira, S. Cavaco, J. Fernandes, I. Moreira, E. Almeida, F. Seabra Pereira, M. Malheiro, F. Cardoso, I. Aragão, T. Cardoso, M. Fister, P. Muraray Govind, N. Brahmananda Reddy, R. Pratheema, E. D. Arul, J. Devachandran, N. Chin-Yee, G. D’Egidio, K. Thavorn, K. Kyeremanteng, A. G. Murchison, K. Swalwell, J. Mandeville, D. Stott, I. Guerreiro, C. Goossens, M. B. Marques, S. Derde, S. Vander Perre, T. Dufour, S. E. Thiessen, F. Güiza, T. Janssens, G. Hermans, I. Vanhorebeek, K. De Bock, G. Van den Berghe, L. Langouche, B. Miles, S. Madden, M. Weiler, P. Marques, C. Rodrigues, M. Boeira, K. Brenner, C. Leães, A. Machado, R. Townsend, J. Andrade, R. Kishore, C. Fenlon, T. Fiks, A. Ruijter, M. Te Raa, P. Spronk, P. Docherty, J. Dickson, E. Moltchanova, C. Scarrot, T. Hall, W. C. Ngu, J. M. Jack, A. Pavli, X. Gee, E. Akin Korhan, M. Shirazy, A. Fayed, S. Gupta, A. Kaushal, S. Dewan, A. Varma, E. Ghosh, L. Yang, L. Eshelman, B. Lord, E. Carlson, R. Broderick, J. Ramos, D. Forte, F. Yang, J. Feeney, K. Wilkinson, K. Shuker, M. Faulds, D. Bryden, L. England, K Shuker, A Tridente, M Faulds, A Matheson, J. Gaynor, D Bryden, S South Yorkshire Hospitals Researc ᅟ, B. Peroni, R. Daglius-Dias, L. Miranda, C. Cohen, C. Carvalho, I. Velasco, J. M. Kelly, A. Neill, G. Rubenfeld, N. Masson, A. Min, E. Boezeman, J. Hofhuis, A. Hovingh, R. De Vries, G. Cabral-Campello, M. Van Mol, M. Nijkamp, E. Kompanje, P. Ostrowski, K. Kiss, B. Köves, V. Csernus, Z. Molnár, Y. Hoydonckx, S. Vanwing, V. Medo, R. Galvez, J. P. Miranda, C. Stone, T. Wigmore, Y. Arunan, A. Wheeler, Y. Wong, C. Poi, C. Gu, P. Molmy, N. Van Grunderbeeck, O. Nigeon, M. Lemyze, D. Thevenin, J. Mallat, M. Correa, R. T. Carvalho, A. Fernandez, C. McBride, E. Koonthalloor, C. Walsh, A. Webber, M. Ashe, K. Smith, E. A. Volakli, M. Dimitriadou, P. Mantzafleri, O. Vrani, A. Arbouti, T. Varsami, J. A. Bollen, T. C. Van Smaalen, W. C. De Jongh, M. M. Ten Hoopen, D. Ysebaert, L. W. Van Heurn, W. N. Van Mook, A. Roze des Ordons, P. Couillard, C. Doig, R. V. Van Keer, R. D. Deschepper, A. F. Francke, L. H. Huyghens, J. B. Bilsen, B. Nyamaizi, C. Dalrymple, A. Dobru, E. Marrinan, A. Ankuli, R. Struthers, R. Crawford, P. Mactavish, P. Morelli, M. Degiovanangelo, F. Lemos, V. MArtinez, J. Cabrera, A. Rutten, S. Van Ieperen, S. De Geer, M. Van Vugt, E. Der Kinderen, A. Giannini, G Miccinesi, T Marchesi, and E Prandi

Subjects
0301 basic medicine, 03 medical and health sciences, medicine.medical_specialty, 030219 obstetrics & reproductive medicine, 030104 developmental biology, 0302 clinical medicine, business.industry, Intensive care, Emergency medicine, Medicine, Critical Care and Intensive Care Medicine, business
Published
2016
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4. Effect of soil disturbance on recharging fluxes: case study on the Snake River Plain, Idaho National Laboratory, USA

Author

John R. Nimmo and Kim S. Perkins

Subjects
Hydrology, Field capacity, Infiltration (hydrology), Hydrogeology, Trench, Vadose zone, Earth and Planetary Sciences (miscellaneous), Groundwater recharge, Water content, Geology, Water Science and Technology, Waste disposal
Abstract

Soil structural disturbance influences the downward flow of water that percolates deep enough to become aquifer recharge. Data from identical experiments in an undisturbed silt-loam soil and in an adjacent simulated waste trench composed of the same soil material, but disturbed, included (1) laboratory- and field-measured unsaturated hydraulic properties and (2) field-measured transient water content profiles through 24 h of ponded infiltration and 75 d of redistribution. In undisturbed soil, wetting fronts were highly diffuse above 2 m depth, and did not go much deeper than 2 m. Darcian analysis suggests an average recharge rate less than 2 mm/year. In disturbed soil, wetting fronts were sharp and initial infiltration slower; water moved slowly below 2 m without obvious impediment. Richards’ equation simulations with realistic conditions predicted sharp wetting fronts, as observed for disturbed soil. Such simulations were adequate for undisturbed soil only if started from a post-initial moisture distribution that included about 3 h of infiltration. These late-started simulations remained good, however, through the 76 d of data. Overall results suggest the net effect of soil disturbance, although it reduces preferential flow, may be to increase recharge by disrupting layer contrasts.

Published
2008
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5. Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4

Author

Archibald S. Perkins, Amy J. Jackson-Fisher, Kevin C K Lloyd, W. Muller, E. Shum, Max Gassmann, David F. Stern, G. Bellinger, and James K Duong

Subjects
Cancer Research, Lung Neoplasms, Receptor, ErbB-4, Blotting, Western, Mammary gland, Mice, Transgenic, Biology, medicine.disease_cause, Polymerase Chain Reaction, Receptor tyrosine kinase, Mice, Tissue culture, ErbB, Genetics, medicine, Animals, Immunoprecipitation, ERBB3, Epidermal growth factor receptor, Molecular Biology, ERBB4, DNA Primers, Base Sequence, Mammary Neoplasms, Experimental, Genes, erbB-2, ErbB Receptors, medicine.anatomical_structure, biology.protein, Cancer research, Carcinogenesis, Gene Deletion
Abstract

The four members of the ErbB family of receptor tyrosine kinases are involved in development and tumorigenesis of the mammary gland. Whereas the epidermal growth factor receptor, ErbB2 and ErbB3 are positively associated with various cancers, clinical studies of ErbB4 in breast cancer are contradictory. Results from tissue culture analyses and some clinical studies suggested that ErbB4 is either a tumor suppressor or is a negative regulator of ErbB2-driven tumors. Neu-Cre-ErbB4(flox/null) mice in which ErbB4 was inactivated by Cre-lox-mediated recombination in the mammary gland developed MMTV-Neu-driven mammary tumors with a similar latency period to mice with one or two wild-type ErbB4 alleles. Moreover, there was no difference in the histologies of tumors that developed, nor in the propensity to form lung metastases. Taken together these results suggest that ErbB4 is not a potent, highly penetrant tumor suppressor, nor is it a factor in Neu-mediated tumorigenesis in this model.

Published
2006
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6. Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2

Author

M McCrann, Archibald S. Perkins, Bogdan Yatsula, and C Galvao

Subjects
Genetics, Cancer Research, Tumor Suppressor Proteins, viruses, DNA Primase, Hematology, Biology, medicine.disease_cause, Friend murine leukemia virus, Mice, Inbred C57BL, Platelet Endothelial Cell Adhesion Molecule-1, Mice, Oncology, Hematologic Neoplasms, medicine, Animals, Humans, Carcinogenesis, Gene, Genes, Neoplasm
Abstract

Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1 , St7 , and Prim2

Published
2005
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7. Gene expression profiling of ErbB receptor and ligand-dependent transcription

Author

David F. Stern, Archibald S. Perkins, and Dhara N. Amin

Subjects
Cancer Research, Receptor, ErbB-4, Transcription, Genetic, Receptor, ErbB-2, Breast Neoplasms, Biology, Ligands, medicine.disease_cause, ErbB, Gene expression, Tumor Cells, Cultured, Genetics, medicine, Humans, HES1, skin and connective tissue diseases, Receptor, Molecular Biology, ERBB4, Oligonucleotide Array Sequence Analysis, Regulation of gene expression, Reverse Transcriptase Polymerase Chain Reaction, Gene Expression Profiling, Up-Regulation, ErbB Receptors, Gene Expression Regulation, Neoplastic, Gene expression profiling, Cancer research, Female, Carcinogenesis
Abstract

Overexpression of ErbB2 and ErbB4 receptors in breast cancers may be accompanied by contrasting clinical outcomes. To investigate the molecular mechanisms contributing to these differences, we undertook a comparative study of gene expression regulated by the two receptors. Agonistic antibodies were employed to activate ErbB2 and ErbB4 in isolation from the other ErbBs in breast cancer cells. Gene expression profiling using a 16 755-gene oligonucleotide array was performed to identify transcriptional targets of receptor activation. Our results indicate that, in the same cell line, ErbB2 and ErbB4 activation influence gene transcription differentially. Although there are genes that are regulated by signaling from both receptors, there are also receptor-specific targets that are preferentially regulated by each receptor. We further show that two ligands acting via the same receptor homodimer may activate different subsets of genes. Many of the induced genes are hitherto unidentified targets of ErbB signaling. These include ErbB4 targets EPS15R, GATA4, and RAB2 and ErbB2-activated HRY/HES1 and PPAP2A. Targets of ErbB2 homodimer signaling may be especially important as markers in breast cancer, where ErbB2 homodimerization mediated by overexpression and ligand-independent activation is common.

Published
2003
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8. Age-related difference in susceptibility of ApcMin/+ mice towards the chemopreventive efficacy of dietary aspirin and curcumin

Author

S. Perkins, Alan Richard Clarke, Andreas J. Gescher, and William P. Steward

Subjects
Adenoma, Male, Aging, Cancer Research, medicine.medical_specialty, Curcumin, Genes, APC, Administration, Oral, Mice, Transgenic, Mice, chemistry.chemical_compound, Internal medicine, Intestinal Neoplasms, Animals, Anticarcinogenic Agents, Humans, chemoprevention, Medicine, Weaning, Genetic Predisposition to Disease, Experimental Therapeutics, Anticarcinogen, Carcinogen, Aspirin, biology, business.industry, ApcMin/+ mice, medicine.disease, Mice, Inbred C57BL, Endocrinology, Oncology, chemistry, Chemoprophylaxis, biology.protein, Female, Cyclooxygenase, business, medicine.drug
Abstract

The nonsteroidal anti-inflammatory drug aspirin and the spice curcumin retard adenoma formation when administered long-term to Apc(Min/+) mice, a model of human familial adenomatous polyposis coli. Both agents interfere with cyclooxygenase activity. When aspirin is administered to Apc(Min/+) mice only postweaning, but not before, it is inefficacious, while curcumin given postweaning is active. Here the hypothesis was tested that dietary aspirin (0.05%) or curcumin (0.2%) prevent or delay adenoma formation in offsprings when administered to Apc(Min/+) mothers and up to the end of weaning, but not afterwards. Whereas curcumin was without effect when administered in this way, aspirin reduced numbers of intestinal adenomas by 21%. When aspirin given up to the end of weaning was combined with curcumin administered from the end of weaning for the rest of the animals' lifetime, intestinal adenoma numbers were reduced by 38%. The combination was not superior to intervention postweaning with curcumin alone. These results show that aspirin exerts chemopreventive activity in the Apc(Min/+) mouse during tumour initiation/early promotion, while curcumin is efficacious when given at a later stage of carcinogenic progression. Thus, the results suggest that in this mouse model aspirin and curcumin act during different 'windows' of neoplastic development.

Published
2003
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9. [Untitled]

Author

James D. Garber and Richard S. Perkins

Subjects
Aqueous solution, Bicarbonate, Inorganic chemistry, Biophysics, Biochemistry, chemistry.chemical_compound, symbols.namesake, Adsorption, chemistry, Transition metal, symbols, Carbonate, Physical and Theoretical Chemistry, Raman spectroscopy, Sodium carbonate, Molecular Biology, Dissolution
Abstract

Surface-enhanced Raman spectroscopy is used for in situ study of an iron surface in aqueous carbonate solutions both on open circuit and at constant potentials. Raman signals are assigned to FeCO3 and adsorbed water. Formation of FeCO3 corresponds to lowering of iron dissolution.

Published
2003
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10. F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4

Author

Nancy A. Jenkins, L. Yang, Y. Wu, Jorge G. Arroyo, Neal G. Copeland, M. Qumsiyeh, Archibald S. Perkins, H. Wu, K. Boyd, T. Savinelli, P. Hu, S. Lin, M. Nimmakayalu, Bruce A. Roe, J. Kone, and A. Prescott

Subjects
Chromosomes, Artificial, Bacterial, Cancer Research, Candidate gene, Proto-Oncogene Protein c-fli-1, Antigens, Polyomavirus Transforming, Virus Integration, Transgene, Mice, Transgenic, Locus (genetics), medicine.disease_cause, Polymerase Chain Reaction, Leukemia, Myelomonocytic, Acute, Mice, Retrovirus, Proviruses, Proto-Oncogene Proteins, medicine, Animals, Humans, Cloning, Molecular, In Situ Hybridization, Fluorescence, DNA Primers, Mice, Inbred C3H, Leukemia, Experimental, biology, Chromosome Mapping, Myeloid leukemia, Hematology, biology.organism_classification, Virology, Molecular biology, Friend murine leukemia virus, DNA-Binding Proteins, Mice, Inbred C57BL, Blotting, Southern, Tumor Virus Infections, Oncology, FLI1, Trans-Activators, Carcinogenesis, Retroviridae Infections
Abstract

We describe here the development of a murine system for the identification of genes involved in myelomonocytic neoplasms. Transgenic C57BL/6J mice expressing SV40 early region under a myelomonocytic promoter develop histiocytic sarcomas with a latency of 167 days. We used retroviral proviral tagging to accelerate tumorigenesis and to uncover genetic changes that contribute to tumor development. Infection of transgenic mice with Friend murine leukemia virus (F-MuLV) shortened the latency of morbidity to 103 days (P< 0.001); this was associated with clonal proviral integrations in tumor DNA. As expected for F-MuLV, proviral insertions occurred at Fli1 in both transgenic and nontransgenic tumors. Four insertions were found at a novel locus, termed Fim4, on chromosome 6. This region is syntenic to human 7q32, a region that is commonly deleted in human myelodysplastic syndrome and acute myeloid leukemia. A murine BAC containing Fim4 was sequenced and analyzed, and while there was significant human-mouse homology in the area of the insertions, no candidate gene has been identified. Thus we have established a system to identify genes involved in myelomonocytic tumors, and have used it to identify Fim4, a new common site of proviral insertion. Study of this locus may provide insight into genes involved in AML-associated 7q32 deletions in humans.

Published
2002
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11. Physicians pursuing the humanities: Benefits and barriers

Author

Julia E. Connelly, Gail J. Povar, Henry S. Perkins, and Howard Brody

Subjects
Health (social science), Health Policy, media_common.quotation_subject, education, Job description, Experiential learning, humanities, Identification (information), Negotiation, Scholarship, Sacrifice, Assertiveness, Narrative, Psychology, Humanities, media_common
Abstract

We surveyed selected physician members of the Society for Health and Human Values (SHHV) to study the benefits and problems of combining a medical career with a strong scholarly interest in the humanities. The 19 usable narrative responses characterized major benefits as experiential base and teaching opportunities. Barriers were numerous and fell under the general headings of: lack of time; lack of institutional rewards; lack of money for research and scholarship; lack of support from humanities peers; lack of suport from medical colleagues; personal financial sacrifice; and lack of training. Some respondents offered creative solutions to these problems, including assertive negotiation of a job description, identification of helpful mentors, and various networking and administrative strategies. The survey results, while preliminary, suggest ways in which SHHV can assist clinicians who wish to develop a serious commitment to humanities study and teaching.

Published
1994
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13. Book reviews

Author

A. Lisa R�nnberg, R�diger Bruch, and Henry S. Perkins

Subjects
Issues, ethics and legal aspects, Public Health, Environmental and Occupational Health, Medicine (miscellaneous), General Medicine
Published
1992
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14. Argon laser panretinal photocoagulation in ischemic central retinal vein occlusion

Author

Patricia Podhajsky, Marie R. Klugman, Sohan Singh Hayreh, Edward S. Perkins, and Gary E. Servais

Subjects
Male, medicine.medical_specialty, Visual acuity, genetic structures, Eye disease, Optic Disk, Iris, Glaucoma, Light Coagulation, Retinal Neovascularization, Cellular and Molecular Neuroscience, Clinical Protocols, Central retinal vein occlusion, Ischemia, Ophthalmology, Retinal Vein Occlusion, medicine, Humans, Prospective Studies, Aged, Randomized Controlled Trials as Topic, Analysis of Variance, Neovascularization, Pathologic, business.industry, Incidence, Diabetic retinopathy, medicine.disease, eye diseases, Sensory Systems, Vitreous Hemorrhage, Surgery, Glaucoma, Neovascular, medicine.anatomical_structure, Data Interpretation, Statistical, Vitreous hemorrhage, Female, sense organs, Visual Fields, medicine.symptom, business, Retinopathy, Optic disc
Abstract

We conducted a prospective, planned study of argon laser panretinal photocoagulation (PRP) in ischemic central retinal vein occlusion (CRVO) over a 10-year period in 123 eyes. On comparing the lasered eyes versus the nonlasered eyes, there was no statistically significant difference between the two groups in the incidence of development of angle neovascularization (NV), neovascular glaucoma (NVG), retinal and/or optic disc NV, or vitreous hemorrhage, or in visual acuity. Our study, however, did show a statistically significant (P = 0.04) difference in the incidence of iris NV between the two groups, with iris NV less prevalent in the laser group than in the nonlaser group, but only when the PRP was performed within 90 days after the onset of CRVO. The other parameter which showed a statistically significant difference between the two groups was the peripheral visual fields-the laser group suffered a significantly (P less than or equal to 0.03) greater loss than the non-laser group. We discuss the implications of these findings in light of the natural history of ischemic CRVO and of ocular NV. Since the original rationale for advocating PRP in ischemic CRVO was the proven beneficial effect of PRP on ocular NV in proliferative diabetic retinopathy, we also discuss the disparities in the disease process between ischemic CRVO and proliferative diabetic retinopathy and in their responses to PRP.

Published
1990
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15. Gotta find GATA a friend

Author

Archibald S. Perkins and Diane S. Krause

Subjects
Genetics, embryonic structures, Transcriptional regulation, General Medicine, Biology, General Biochemistry, Genetics and Molecular Biology
Abstract

Discovery of a cofactor for GATA-1 opens new avenues of investigation into the transcriptional regulation of hematopoiesis.

Published
1997
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18. Book reviews

Author

Howard A. Roberts, Warren Viessman, Steven J. Rosenthal, Stephen S. Perkins, Jon Mendelson, Herman Sievering, Richard Freeman, D. J. Schaeffer, null J. G., Robert E. Morcock, and Glen R. Harris

Subjects
Global and Planetary Change, Ecology, Pollution
Published
1981
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19. Ethics at the end of life

Author

Henry S. Perkins

Subjects
Male, Resuscitation, Common law, medicine.medical_treatment, Decision Making, education, Patient Advocacy, Risk Assessment, 01 natural sciences, Patient advocacy, Right to die, 03 medical and health sciences, 0302 clinical medicine, Internal Medicine, medicine, Humans, Ethics, Medical, 030212 general & internal medicine, Cardiopulmonary resuscitation, 0101 mathematics, health care economics and organizations, Aged, Terminal Care, business.industry, Patient Selection, Right to Die, 010102 general mathematics, Bioethics, medicine.disease, Texas, Medical emergency, Resuscitation Decisions, business, Algorithms, Medical ethics
Abstract

Some of the physician's most difficult decisions involve whether to give cardiopulmonary resuscitation (CPR). Current research, hospital policies, and case law provide little guidance for these decisions, but medical ethics offers three useful principles. All three are based on patients' wishes. First, a victim of cardiopulmonary arrest should receive CPR unless compelling reasons indicate he would not want it. Second, a patient has the right to refuse CPR. Finally, if CPR will serve no therapeutic goals defined from the patient's wishes, it should not be given. Applying these principles requires a sympathetic, directed history which elicits the patient's wishes relevant to resuscitation. This article uses an actual case and a simple algorithm to show how these principles promote ethically sound resuscitation decisions.

Published
1986
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20. Rectification effect in thin-film superconductors in small, oscillatory magnetic fields

Author

H. S. Perkins and R.P. Huebener

Subjects
Superconductivity, Materials science, Condensed matter physics, Electrical resistivity and conductivity, Magnet, General Materials Science, Magnetic pressure, Electric potential, Condensed Matter Physics, Magnetic reactance, Critical field, Atomic and Molecular Physics, and Optics, Magnetic field
Abstract

We have observed the generation of dc voltages across super conducting films of lead and tin due to the presence of a static magnetic fieldH0 upon which a small, oscillatory magnetic field component is superimposed. The voltages are created without an external current passing though the samples. They change sign with a reversal of the static fieldH0. The voltages are related to superconductivity and seem to be caused by a nonsymmetric penetration into the specimen of the magnetic field variation. During one cycle of the magnetic field oscillation a small fraction of the total flux entering and leaving the sample appears to be “pumped across” the specimen in a preferential direction. The thickness of the films ranged between 0.16 and 2.5 µm. The frequency ω and the amplitudeH1 of the oscillatory field was varied from 5 to 120 kHz and from 0 to 2 G rms, respectively. The rectified voltage varies between the different samples and depends uponH0, ω,H1, and the orientation of the film relative to the magnetic field. It generally shows a sharp peak near the critical magnetic field. Small rectified voltages caused by the oscillatory field were observed far above the nominal, critical magnetic fields of the films. Apparently, these voltages were associated with the film edges and the enhancement of the critical field at the edges.

Published
1971
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21. Book reviews

Author

null Robert, Suzanne Fletcher, C. Stewart Rogers, Henry S. Perkins, Anne Scheetz, and William B. Herring

Subjects
Internal Medicine
Published
1988
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22. Book reviews

Author

Laurie Dornbrand, Russell Harris, Gustav Magrinat, and Henry S. Perkins

Subjects
Internal Medicine
Published
1986
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23. Beam-Solid Interactions of Pyrolytic Graphite as a Function of Angle of Cut Surface

Author

Pearl W. Yip, Janet S. Perkins, and Donald J. Jaklitsch

Subjects
Diffraction, Materials science, chemistry, Scanning electron microscope, Impurity, Analytical chemistry, chemistry.chemical_element, Crystal growth, Pyrolytic carbon, Carbon, Intensity (heat transfer), Beam (structure)
Abstract

A study to examine beam-solid interaction as a function of the cut surfaces of pyrolytic graphite samples (0, 30, 60, and 90 degrees relative to the basal plane) was made using a high intensity, carbon dioxide laser beam operating at a wavelength of 10.6 μm.Crystal growth of redeposited carbon and impurities in the burn area as well as a melt on the burn edge were observed and examined using Scanning Electron (SEM) and Scanning Auger Microscopy (SAM). Similarities and differences relating to the structure of the material were further investigated using X-ray diffraction. Thermal transport properties as a function of angle were also examined.

Published
1986
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24. Chemical Reaction Products from Interaction of High-Energy Beams with Composites

Author

D. J. Jaklitsch, A. F. Connolly, J. S. Perkins, P. W. Wong, and S. S. Lin

Subjects
High energy, Materials science, chemistry, Doping, chemistry.chemical_element, Composite material, Chemical reaction, Carbon
Abstract

In a study to examine the effect of irradiating a number of silica- and carbon-reinforced composites with high-energy beams, surface analytical techniques have proved especially effective in revealing reactions between undoped or doped matrices and silica or carbon reinforcements, respectively.

Published
1984
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