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71 results on '"Sørensen, Thorkild I. A."'

4. Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection

Author

Kays Mohammed Ali, Younes, primary, Dolin, Troels Gammeltoft, additional, Damm Nybing, Janus, additional, Lykke, Jakob, additional, Hvid Linden, Frederik, additional, Høgh-Schmidt, Erik, additional, Sørensen, Thorkild I. A., additional, Christensen, Jesper Frank, additional, Nielsen, Yousef J. W., additional, Stenfatt Larsen, Jim, additional, Madsbad, Sten, additional, Sidenius Johansen, Julia, additional, Svane, Maria Saur, additional, and Lang Lehrskov, Louise, additional

Published
2024
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6. Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author

Kadalayil, Latha, primary, Alam, Md. Zahangir, additional, White, Cory Haley, additional, Ghantous, Akram, additional, Walton, Esther, additional, Gruzieva, Olena, additional, Merid, Simon Kebede, additional, Kumar, Ashish, additional, Roy, Ritu P., additional, Solomon, Olivia, additional, Huen, Karen, additional, Eskenazi, Brenda, additional, Rzehak, Peter, additional, Grote, Veit, additional, Langhendries, Jean-Paul, additional, Verduci, Elvira, additional, Ferre, Natalia, additional, Gruszfeld, Darek, additional, Gao, Lu, additional, Guan, Weihua, additional, Zeng, Xuehuo, additional, Schisterman, Enrique F., additional, Dou, John F., additional, Bakulski, Kelly M., additional, Feinberg, Jason I., additional, Soomro, Munawar Hussain, additional, Pesce, Giancarlo, additional, Baiz, Nour, additional, Isaevska, Elena, additional, Plusquin, Michelle, additional, Vafeiadi, Marina, additional, Roumeliotaki, Theano, additional, Langie, Sabine A. S., additional, Standaert, Arnout, additional, Allard, Catherine, additional, Perron, Patrice, additional, Bouchard, Luigi, additional, van Meel, Evelien R., additional, Felix, Janine F., additional, Jaddoe, Vincent W. V., additional, Yousefi, Paul D., additional, Ramlau-Hansen, Cecilia H., additional, Relton, Caroline L., additional, Tobi, Elmar W., additional, Starling, Anne P., additional, Yang, Ivana V., additional, Llambrich, Maria, additional, Santorelli, Gillian, additional, Lepeule, Johanna, additional, Salas, Lucas A., additional, Bustamante, Mariona, additional, Ewart, Susan L., additional, Zhang, Hongmei, additional, Karmaus, Wilfried, additional, Röder, Stefan, additional, Zenclussen, Ana Claudia, additional, Jin, Jianping, additional, Nystad, Wenche, additional, Page, Christian M., additional, Magnus, Maria, additional, Jima, Dereje D., additional, Hoyo, Cathrine, additional, Maguire, Rachel L., additional, Kvist, Tuomas, additional, Czamara, Darina, additional, Räikkönen, Katri, additional, Gong, Tong, additional, Ullemar, Vilhelmina, additional, Rifas-Shiman, Sheryl L., additional, Oken, Emily, additional, Almqvist, Catarina, additional, Karlsson, Robert, additional, Lahti, Jari, additional, Murphy, Susan K., additional, Håberg, Siri E., additional, London, Stephanie, additional, Herberth, Gunda, additional, Arshad, Hasan, additional, Sunyer, Jordi, additional, Grazuleviciene, Regina, additional, Dabelea, Dana, additional, Steegers-Theunissen, Régine P. M., additional, Nohr, Ellen A., additional, Sørensen, Thorkild I. A., additional, Duijts, Liesbeth, additional, Hivert, Marie-France, additional, Nelen, Vera, additional, Popovic, Maja, additional, Kogevinas, Manolis, additional, Nawrot, Tim S., additional, Herceg, Zdenko, additional, Annesi-Maesano, Isabella, additional, Fallin, M. Daniele, additional, Yeung, Edwina, additional, Breton, Carrie V., additional, Koletzko, Berthold, additional, Holland, Nina, additional, Wiemels, Joseph L., additional, Melén, Erik, additional, Sharp, Gemma C., additional, Silver, Matt J., additional, Rezwan, Faisal I., additional, and Holloway, John W., additional

Published
2023
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9. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Author

Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Søren Karl, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, Swertz, Morris, Wijmenga, Tjitske Nienke, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Wolffenbuttel, Bruce H. R., Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., Hoed, Marcel den, Epidemiology, Internal Medicine, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine, Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J, Moore, Tim, Hyppönen, Elina, den Hoed, Marcel, Lifelines Cohort Study, Alizadeh, B.Z., Boezen, H.M., Franke, L., Swertz, M., Wijmenga, C., van der Harst, P., Navis, G., Rots, M., Wolffenbuttel, BHR, Wang, Zhe [0000-0002-8046-4969], Emmerich, Andrew [0000-0002-0908-9924], Pillon, Nicolas J [0000-0003-1107-9490], Moore, Tim [0000-0003-4250-3370], Ameur, Adam [0000-0001-6085-6749], Bis, Joshua C [0000-0002-3409-1110], Boehnke, Michael [0000-0002-6442-7754], Bouchard, Claude [0000-0002-0048-491X], Chasman, Daniel I [0000-0003-3357-0862], Smith, George Davey [0000-0002-1407-8314], de Geus, Eco JC [0000-0001-6022-2666], Dörr, Marcus [0000-0001-7471-475X], Ferrucci, Luigi [0000-0002-6273-1613], Fornage, Myriam [0000-0003-0677-8158], Garland, Theodore [0000-0002-7916-3552], Gyllensten, Ulf [0000-0002-6316-3355], Hansen, Torben [0000-0001-8748-3831], Horta, Bernardo L [0000-0001-9843-412X], Hyppönen, Elina [0000-0003-3670-9399], Johnson, W Craig [0000-0002-3161-3753], Kiemeney, Lambertus A [0000-0002-2368-1326], Laakso, Markku [0000-0002-3394-7749], Langenberg, Claudia [0000-0002-5017-7344], Lehtimäki, Terho [0000-0002-2555-4427], Magnusson, Patrik KE [0000-0002-7315-7899], Martin, Nicholas G [0000-0003-4069-8020], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Meyre, David [0000-0003-4850-7444], North, Kari E [0000-0002-8903-0366], Ohlsson, Claes [0000-0002-9633-2805], Oldehinkel, Albertine J [0000-0003-3925-3913], Orho-Melander, Marju [0000-0002-3578-2503], Pare, Guillaume [0000-0002-6795-4760], Park, Taesung [0000-0002-8294-590X], Pedersen, Oluf [0000-0002-3321-3972], Pers, Tune H [0000-0003-0207-4831], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Rotimi, Charles N [0000-0001-5759-053X], Sim, Xueling [0000-0002-1233-7642], Snieder, Harold [0000-0003-1949-2298], Sørensen, Thorkild IA [0000-0003-4821-430X], Spector, Tim D [0000-0002-9795-0365], Timpson, Nicholas J [0000-0002-7141-9189], Voortman, Trudy [0000-0003-2830-6813], Waeber, Gérard [0000-0003-4193-788X], Wareham, Nicholas J [0000-0003-1422-2993], Weir, David R [0000-0002-1661-2402], Wilson, James F [0000-0001-5751-9178], Krook, Anna [0000-0002-0891-0258], Zierath, Juleen R [0000-0001-6891-7497], Thomis, Martine AI [0000-0001-9093-2191], Loos, Ruth JF [0000-0002-8532-5087], Hoed, Marcel den [0000-0001-8081-428X], Apollo - University of Cambridge Repository, Center for Liver, Digestive and Metabolic Diseases (CLDM), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Geriatrics, AMS - Ageing & Vitality, APH - Aging & Later Life, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, and AMS - Sports

Subjects
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 631/208/205/2138, 610 Medicine & health, heritability, Actinin/genetics, Cross-Sectional Studies, Exercise/physiology, Genome-Wide Association Study, Humans, Leisure Activities, Sedentary Behavior, apolipoprotein-e genotype, Lifelines Cohort Study, 360 Social problems & social services, 692/308/575, Genetics, Actinin, Exercise, Medicinsk genetik, exercise, APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS, 360 Soziale Probleme, Sozialdienste, 692/308/2056, article, gwas, gene-expression, mortality, 3142 Public health care science, environmental and occupational health, fitness, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], LD score regression, 3111 Biomedicine, 610 Medizin und Gesundheit, Medical Genetics, complex, performance
Abstract

Funder: Kjell och Märta Beijers Stiftelse (Kjell and Marta Beijer Foundation); doi: https://doi.org/10.13039/501100006353, Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.

Published
2022
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10. Changing genetic architecture of body mass index from infancy to early adulthood: an individual based pooled analysis of 25 twin cohorts

Author

Silventoinen, Karri, primary, Li, Weilong, additional, Jelenkovic, Aline, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Aaltonen, Sari, additional, Piirtola, Maarit, additional, Sugawara, Masumi, additional, Tanaka, Mami, additional, Matsumoto, Satoko, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Tynelius, Per, additional, Rasmussen, Finn, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E. M., additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik K. E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, and Kaprio, Jaakko, additional

Published
2022
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11. Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

Author

Silventoinen, Karri, primary, Piirtola, Maarit, additional, Jelenkovic, Aline, additional, Sund, Reijo, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Honda, Chika, additional, Inui, Fujio, additional, Tomizawa, Rie, additional, Watanabe, Mikio, additional, Sakai, Norio, additional, Gatz, Margaret, additional, Butler, David A., additional, Lee, Jooyeon, additional, Lee, Soo Ji, additional, Sung, Joohon, additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Tynelius, Per, additional, Rasmussen, Finn, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Harris, Jennifer R., additional, Tyler, Jessica, additional, Hopper, John L., additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Dahl Aslan, Anna K., additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Rebato, Esther, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Tan, Qihua, additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Korhonen, Tellervo, additional, and Kaprio, Jaakko, additional

Published
2022
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18. Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes

Author

Deelen, Joris, primary, Evans, Daniel S., additional, Arking, Dan E., additional, Tesi, Niccolò, additional, Nygaard, Marianne, additional, Liu, Xiaomin, additional, Wojczynski, Mary K., additional, Biggs, Mary L., additional, van der Spek, Ashley, additional, Atzmon, Gil, additional, Ware, Erin B., additional, Sarnowski, Chloé, additional, Smith, Albert V., additional, Seppälä, Ilkka, additional, Cordell, Heather J., additional, Dose, Janina, additional, Amin, Najaf, additional, Arnold, Alice M., additional, Ayers, Kristin L., additional, Barzilai, Nir, additional, Becker, Elizabeth J., additional, Beekman, Marian, additional, Blanché, Hélène, additional, Christensen, Kaare, additional, Christiansen, Lene, additional, Collerton, Joanna C., additional, Cubaynes, Sarah, additional, Cummings, Steven R., additional, Davies, Karen, additional, Debrabant, Birgit, additional, Deleuze, Jean-François, additional, Duncan, Rachel, additional, Faul, Jessica D., additional, Franceschi, Claudio, additional, Galan, Pilar, additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Huisman, Martijn, additional, Hurme, Mikko A., additional, Jagger, Carol, additional, Jansen, Iris, additional, Jylhä, Marja, additional, Kähönen, Mika, additional, Karasik, David, additional, Kardia, Sharon L. R., additional, Kingston, Andrew, additional, Kirkwood, Thomas B. L., additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lyytikäinen, Leo-Pekka, additional, Martin-Ruiz, Carmen, additional, Min, Junxia, additional, Nebel, Almut, additional, Newman, Anne B., additional, Nie, Chao, additional, Nohr, Ellen A., additional, Orwoll, Eric S., additional, Perls, Thomas T., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Reinders, Marcel J. T., additional, Robine, Jean-Marie, additional, Rotter, Jerome I., additional, Sebastiani, Paola, additional, Smith, Jennifer, additional, Sørensen, Thorkild I. A., additional, Taylor, Kent D., additional, Uitterlinden, André G., additional, van der Flier, Wiesje, additional, van der Lee, Sven J., additional, van Duijn, Cornelia M., additional, van Heemst, Diana, additional, Vaupel, James W., additional, Weir, David, additional, Ye, Kenny, additional, Zeng, Yi, additional, Zheng, Wanlin, additional, Holstege, Henne, additional, Kiel, Douglas P., additional, Lunetta, Kathryn L., additional, Slagboom, P. Eline, additional, and Murabito, Joanne M., additional

Published
2021
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19. Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

Author

Sammallahti, Sara, primary, Cortes Hidalgo, Andrea P., additional, Tuominen, Samuli, additional, Malmberg, Anni, additional, Mulder, Rosa H., additional, Brunst, Kelly J., additional, Alemany, Silvia, additional, McBride, Nancy S., additional, Yousefi, Paul, additional, Heiss, Jonathan A., additional, McRae, Nia, additional, Page, Christian M., additional, Jin, Jianping, additional, Pesce, Giancarlo, additional, Caramaschi, Doretta, additional, Rifas-Shiman, Sheryl L., additional, Koen, Nastassja, additional, Adams, Charleen D., additional, Magnus, Maria C., additional, Baïz, Nour, additional, Ratanatharathorn, Andrew, additional, Czamara, Darina, additional, Håberg, Siri E., additional, Colicino, Elena, additional, Baccarelli, Andrea A., additional, Cardenas, Andres, additional, DeMeo, Dawn L., additional, Lawlor, Deborah A., additional, Relton, Caroline L., additional, Felix, Janine F., additional, van IJzendoorn, Marinus H., additional, Bakermans-Kranenburg, Marian J., additional, Kajantie, Eero, additional, Räikkönen, Katri, additional, Sunyer, Jordi, additional, Sharp, Gemma C., additional, Houtepen, Lotte C., additional, Nohr, Ellen A., additional, Sørensen, Thorkild I. A., additional, Téllez-Rojo, Martha M., additional, Wright, Robert O., additional, Annesi-Maesano, Isabella, additional, Wright, John, additional, Hivert, Marie-France, additional, Wright, Rosalind J., additional, Zar, Heather J., additional, Stein, Dan J., additional, London, Stephanie J., additional, Cecil, Charlotte A. M., additional, Tiemeier, Henning, additional, and Lahti, Jari, additional

Published
2021
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20. DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Author

Vehmeijer, Florianne O. L., primary, Küpers, Leanne K., additional, Sharp, Gemma C., additional, Salas, Lucas A., additional, Lent, Samantha, additional, Jima, Dereje D., additional, Tindula, Gwen, additional, Reese, Sarah, additional, Qi, Cancan, additional, Gruzieva, Olena, additional, Page, Christian, additional, Rezwan, Faisal I., additional, Melton, Philip E., additional, Nohr, Ellen, additional, Escaramís, Geòrgia, additional, Rzehak, Peter, additional, Heiskala, Anni, additional, Gong, Tong, additional, Tuominen, Samuli T., additional, Gao, Lu, additional, Ross, Jason P., additional, Starling, Anne P., additional, Holloway, John W., additional, Yousefi, Paul, additional, Aasvang, Gunn Marit, additional, Beilin, Lawrence J., additional, Bergström, Anna, additional, Binder, Elisabeth, additional, Chatzi, Leda, additional, Corpeleijn, Eva, additional, Czamara, Darina, additional, Eskenazi, Brenda, additional, Ewart, Susan, additional, Ferre, Natalia, additional, Grote, Veit, additional, Gruszfeld, Dariusz, additional, Håberg, Siri E., additional, Hoyo, Cathrine, additional, Huen, Karen, additional, Karlsson, Robert, additional, Kull, Inger, additional, Langhendries, Jean-Paul, additional, Lepeule, Johanna, additional, Magnus, Maria C., additional, Maguire, Rachel L., additional, Molloy, Peter L., additional, Monnereau, Claire, additional, Mori, Trevor A., additional, Oken, Emily, additional, Räikkönen, Katri, additional, Rifas-Shiman, Sheryl, additional, Ruiz-Arenas, Carlos, additional, Sebert, Sylvain, additional, Ullemar, Vilhelmina, additional, Verduci, Elvira, additional, Vonk, Judith M., additional, Xu, Cheng-jian, additional, Yang, Ivana V., additional, Zhang, Hongmei, additional, Zhang, Weiming, additional, Karmaus, Wilfried, additional, Dabelea, Dana, additional, Muhlhausler, Beverly S., additional, Breton, Carrie V., additional, Lahti, Jari, additional, Almqvist, Catarina, additional, Jarvelin, Marjo-Riitta, additional, Koletzko, Berthold, additional, Vrijheid, Martine, additional, Sørensen, Thorkild I. A., additional, Huang, Rae-Chi, additional, Arshad, Syed Hasan, additional, Nystad, Wenche, additional, Melén, Erik, additional, Koppelman, Gerard H., additional, London, Stephanie J., additional, Holland, Nina, additional, Bustamante, Mariona, additional, Murphy, Susan K., additional, Hivert, Marie-France, additional, Baccarelli, Andrea, additional, Relton, Caroline L., additional, Snieder, Harold, additional, Jaddoe, Vincent W. V., additional, and Felix, Janine F., additional

Published
2020
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21. Genetic and environmental variation in educational attainment: an individual-based analysis of 28 twin cohorts

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Latvala, Antti, additional, Honda, Chika, additional, Inui, Fujio, additional, Tomizawa, Rie, additional, Watanabe, Mikio, additional, Sakai, Norio, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Tyler, Jessica, additional, Hopper, John L., additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Calais-Ferreira, Lucas, additional, Oliveira, Vinicius C., additional, Ferreira, Paulo H., additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Tynelius, Per, additional, Rasmussen, Finn, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Pang, Zengchang, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Dahl Aslan, Anna K., additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Harris, Jennifer R., additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E. M., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Kandler, Christian, additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Gatz, Margaret, additional, Butler, David A., additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Park, Hang A., additional, Lee, Jooyeon, additional, Lee, Soo Ji, additional, Sung, Joohon, additional, Yokoyama, Yoshie, additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, and Kaprio, Jaakko, additional

Published
2020
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25. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Author

Jelenkovic, Aline, primary, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Latvala, Antti, additional, Sugawara, Masumi, additional, Tanaka, Mami, additional, Matsumoto, Satoko, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Saudino, Kimberly J., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik K. E., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Sung, Joohon, additional, Kim, Jina, additional, Lee, Jooyeon, additional, Lee, Sooji, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A., additional, Harris, Jennifer R., additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Lichtenstein, Paul, additional, Bartels, Meike, additional, Beijsterveldt, Catharina E. M. van, additional, Willemsen, Gonneke, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Jeong, Hoe-Uk, additional, Hur, Yoon-Mi, additional, Turkheimer, Eric, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2020
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26. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

Author

Zheng, Yan, primary, Huang, Tao, additional, Wang, Tiange, additional, Mei, Zhendong, additional, Sun, Zhonghan, additional, Zhang, Tao, additional, Ellervik, Christina, additional, Chai, Jin-Fang, additional, Sim, Xueling, additional, van Dam, Rob M., additional, Tai, E-Shyong, additional, Koh, Woon-Puay, additional, Dorajoo, Rajkumar, additional, Saw, Seang-Mei, additional, Sabanayagam, Charumathi, additional, Wong, Tien Yin, additional, Gupta, Preeti, additional, Rossing, Peter, additional, Ahluwalia, Tarunveer S., additional, Vinding, Rebecca K., additional, Bisgaard, Hans, additional, Bønnelykke, Klaus, additional, Wang, Yujie, additional, Graff, Mariaelisa, additional, Voortman, Trudy, additional, van Rooij, Frank J. A., additional, Hofman, Albert, additional, van Heemst, Diana, additional, Noordam, Raymond, additional, Estampador, Angela C., additional, Varga, Tibor V., additional, Enzenbach, Cornelia, additional, Scholz, Markus, additional, Thiery, Joachim, additional, Burkhardt, Ralph, additional, Orho-Melander, Marju, additional, Schulz, Christina-Alexandra, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Kubo, Michiaki, additional, Akiyama, Masato, additional, Zhou, Ang, additional, Kilpeläinen, Tuomas O., additional, Hansen, Torben, additional, Kleber, Marcus E., additional, Delgado, Graciela, additional, McCarthy, Mark, additional, Lemaitre, Rozenn N., additional, Felix, Janine F., additional, Jaddoe, Vincent W. V., additional, Wu, Ying, additional, Mohlke, Karen L., additional, Lehtimäki, Terho, additional, Wang, Carol A., additional, Pennell, Craig E., additional, Schunkert, Heribert, additional, Kessler, Thorsten, additional, Zeng, Lingyao, additional, Willenborg, Christina, additional, Peters, Annette, additional, Lieb, Wolfgang, additional, Grote, Veit, additional, Rzehak, Peter, additional, Koletzko, Berthold, additional, Erdmann, Jeanette, additional, Munz, Matthias, additional, Wu, Tangchun, additional, He, Meian, additional, Yu, Caizheng, additional, Lecoeur, Cécile, additional, Froguel, Philippe, additional, Corella, Dolores, additional, Moreno, Luis A., additional, Lai, Chao-Qiang, additional, Pitkänen, Niina, additional, Boreham, Colin A., additional, Ridker, Paul M., additional, Rosendaal, Frits R., additional, de Mutsert, Renée, additional, Power, Chris, additional, Paternoster, Lavinia, additional, Sørensen, Thorkild I. A., additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Djousse, Luc, additional, Rivadeneira, Fernando, additional, Lee, Nanette R., additional, Raitakari, Olli T., additional, Kähönen, Mika, additional, Viikari, Jorma, additional, Langhendries, Jean-Paul, additional, Escribano, Joaquin, additional, Verduci, Elvira, additional, Dedoussis, George, additional, König, Inke, additional, Balkau, Beverley, additional, Coltell, Oscar, additional, Dallongeville, Jean, additional, Meirhaeghe, Aline, additional, Amouyel, Philippe, additional, Gottrand, Frédéric, additional, Pahkala, Katja, additional, Niinikoski, Harri, additional, Hyppönen, Elina, additional, März, Winfried, additional, Mackey, David A., additional, Gruszfeld, Dariusz, additional, Tucker, Katherine L., additional, Fumeron, Frédéric, additional, Estruch, Ramon, additional, Ordovas, Jose M., additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Mozaffarian, Dariush, additional, Psaty, Bruce M., additional, North, Kari E., additional, Chasman, Daniel I., additional, and Qi, Lu, additional

Published
2020
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29. The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

Author

Schnurr, Theresia M., primary, Morgen, Camilla S., additional, Borisevich, Dmitrii, additional, Beaumont, Robin N., additional, Engelbrechtsen, Line, additional, Ängquist, Lars, additional, Have, Christian T., additional, Freathy, Rachel M., additional, Smith, George Davey, additional, Nohr, Ellen A., additional, Hansen, Torben, additional, and Sørensen, Thorkild I. A., additional

Published
2020
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30. Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Author

Merid, Simon Kebede, primary, Novoloaca, Alexei, additional, Sharp, Gemma C., additional, Küpers, Leanne K., additional, Kho, Alvin T., additional, Roy, Ritu, additional, Gao, Lu, additional, Annesi-Maesano, Isabella, additional, Jain, Pooja, additional, Plusquin, Michelle, additional, Kogevinas, Manolis, additional, Allard, Catherine, additional, Vehmeijer, Florianne O., additional, Kazmi, Nabila, additional, Salas, Lucas A., additional, Rezwan, Faisal I., additional, Zhang, Hongmei, additional, Sebert, Sylvain, additional, Czamara, Darina, additional, Rifas-Shiman, Sheryl L., additional, Melton, Phillip E., additional, Lawlor, Debbie A., additional, Pershagen, Göran, additional, Breton, Carrie V., additional, Huen, Karen, additional, Baiz, Nour, additional, Gagliardi, Luigi, additional, Nawrot, Tim S., additional, Corpeleijn, Eva, additional, Perron, Patrice, additional, Duijts, Liesbeth, additional, Nohr, Ellen Aagaard, additional, Bustamante, Mariona, additional, Ewart, Susan L., additional, Karmaus, Wilfried, additional, Zhao, Shanshan, additional, Page, Christian M., additional, Herceg, Zdenko, additional, Jarvelin, Marjo-Riitta, additional, Lahti, Jari, additional, Baccarelli, Andrea A., additional, Anderson, Denise, additional, Kachroo, Priyadarshini, additional, Relton, Caroline L., additional, Bergström, Anna, additional, Eskenazi, Brenda, additional, Soomro, Munawar Hussain, additional, Vineis, Paolo, additional, Snieder, Harold, additional, Bouchard, Luigi, additional, Jaddoe, Vincent W., additional, Sørensen, Thorkild I. A., additional, Vrijheid, Martine, additional, Arshad, S. Hasan, additional, Holloway, John W., additional, Håberg, Siri E., additional, Magnus, Per, additional, Dwyer, Terence, additional, Binder, Elisabeth B., additional, DeMeo, Dawn L., additional, Vonk, Judith M., additional, Newnham, John, additional, Tantisira, Kelan G., additional, Kull, Inger, additional, Wiemels, Joseph L., additional, Heude, Barbara, additional, Sunyer, Jordi, additional, Nystad, Wenche, additional, Munthe-Kaas, Monica C., additional, Räikkönen, Katri, additional, Oken, Emily, additional, Huang, Rae-Chi, additional, Weiss, Scott T., additional, Antó, Josep Maria, additional, Bousquet, Jean, additional, Kumar, Ashish, additional, Söderhäll, Cilla, additional, Almqvist, Catarina, additional, Cardenas, Andres, additional, Gruzieva, Olena, additional, Xu, Cheng-Jian, additional, Reese, Sarah E., additional, Kere, Juha, additional, Brodin, Petter, additional, Solomon, Olivia, additional, Wielscher, Matthias, additional, Holland, Nina, additional, Ghantous, Akram, additional, Hivert, Marie-France, additional, Felix, Janine F., additional, Koppelman, Gerard H., additional, London, Stephanie J., additional, and Melén, Erik, additional

Published
2020
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32. Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

Author

van der Lee, Sven J, Conway, Olivia J, Zettergren, Anna, Christensen, Kaare, Ertekin-Taner, Nilüfer, Scholz, Sonja W, Ramirez, Alfredo, Ruiz, Agustín, Slagboom, Eline, van der Flier, Wiesje M, Holstege, Henne, Mead, S., Synofzik, M., Andlauer, Till F M, van Swieten, J. C., Leber, I., Ferrari, R., Hernandez, D. G., Nalls, M. A., Rohrer, J. D., Ramasamy, A., Kwok, J. B. J., Dobson-Stone, C., Schofield, P. R., Diez-Fairen, Monica, Halliday, G. M., Hodges, J. R., Piguet, O., Bartley, L., Thompson, E., Borroni, B., Padovani, A., Cruchaga, C., Cairns, N. J., Benussi, L., Simon-Sanchez, Javier, Binetti, G., Ghidoni, R., Forloni, G., Albani, D., Galimberti, D., Fenoglio, C., Serpente, M., Scarpini, E., Blesa, R., Landqvist Waldö, M., Lleó, Alberto, Nilsson, K., Nilsson, C., Mackenzie, I. R. A., Hsiung, G-Y R, Mann, D. M. A., Grafman, J., Morris, C. M., Attems, J., Griffiths, T. D., McKeith, I. G., Zetterberg, Henrik, Thomas, A. J., Pietrini, P., Huey, E. D., Wassermann, E. M., Baborie, A., Jaros, E., Tierney, M. C., Razquin, C., Ortega-Cubero, S., Alonso, E., Nygaard, Marianne, Perneczky, R., Diehl-Schmid, J., Alexopoulos, P., Kurz, A., Rainero, I., Rubino, E., Pinessi, L., Rogaeva, E., St George-Hyslop, P., Rossi, G., Blauwendraat, Cornelis, Tagliavini, F., Giaccone, G., Rowe, J. B., Schlachetzki, J. C. M., Uphill, J., Collinge, J., Danek, A., Van Deerlin, V. M., Grossman, M., Trojanowski, J. Q., Savage, Jeanne E, van der Zee, J., Van Broeckhoven, C., Cappa, S. F., Hannequin, D., Golfier, V., Vercelletto, M., Brice, A., Nacmias, B., Sorbi, S., Bagnoli, S., Mengel-From, Jonas, Piaceri, I., Nielsen, J. E., Hjermind, L. E., Riemenschneider, M., Mayhaus, M., Ibach, B., Gasparoni, G., Pichler, S., Gu, W., Rossor, M. N., Jansen, Iris, Moreno-Grau, Sonia, Fox, N. C., Warren, J. D., Spillantini, M. G., Morris, H. R., Rizzu, P., Snowden, J. S., Rollinson, S., Richardson, A., Gerhard, A., Bruni, A. C., Wagner, Michael, Maletta, R., Frangipane, F., Cupidi, C., Bernardi, L., Anfossi, M., Gallo, M., Conidi, M. E., Smirne, N., Baker, M., Josephs, K. A., Fortea, Juan, Parisi, J. E., Seeley, W. W., Miller, B. L., Karydas, A. M., Rosen, H., Dopper, E. G. P., Seelaar, H., Logroscino, G., Capozzo, R., Novelli, V., Keogh, Michael J, Puca, A. A., Franceschi, M., Postiglione, A., Milan, G., Sorrentino, P., Kristiansen, M., Chiang, H-H, Graff, C., Pasquier, F., Rollin, A., Blennow, Kaj, Deramecourt, V., Lebouvier, T., Kapogiannis, D., Ferrucci, L., Pickering-Brown, S., Singleton, A. B., Hardy, J., Momeni, P., Coppola, G., Skoog, Ingmar, Varpetian, A., Foroud, T. M., Levey, A. I., Kukull, W. A., Mendez, M. F., Ringman, J., Chui, H., Cotman, C., DeCarli, C., Friese, Manuel A, Geschwind, D. H., Pletnikova, Olga, Zulaica, Miren, Lage, Carmen, Carrasquillo, Minerva M, de Rojas, Itziar, Riedel-Heller, Steffi, Illán-Gala, Ignacio, Wei, Wei, Jeune, Bernard, Orellana, Adelina, Then Bergh, Florian, Wang, Xue, Hulsman, Marc, Beker, Nina, Kleineidam, Luca, Tesi, Niccolo, Morris, Christopher M, Indakoetxea, Begoña, Collij, Lyduine E, Scherer, Martin, Morenas-Rodríguez, Estrella, Ironside, James W, van Berckel, Bart N M, Alcolea, Daniel, Wiendl, Heinz, van den Akker, Erik, Strickland, Samantha L, Pastor, Pau, Rodríguez Rodríguez, Eloy, DESGESCO, EADB, IFGC, IPDGC, RiMod-FTD, Bank, Netherlands Brain, Boeve, Bradley F, Hernández, Isabel, Petersen, Ronald C, Ferman, Tanis J, van Gerpen, Jay A, Reinders, Marcel J T, Uitti, Ryan J, Tárraga, Lluís, Maier, Wolfgang, Dols-Icardo, Oriol, Kawalia, Amit, Dalmasso, Maria Carolina, van Eijk, Kristel R, Boada, Mercè, Zettl, Uwe K, van Schoor, Natasja M, Beekman, Marian, Allen, Mariet, Masliah, Eliezer, de Munain, Adolfo López, Pantelyat, Alexander, Wszolek, Zbigniew K, Ross, Owen A, Stringa, Najada, Dickson, Dennis W, Graff-Radford, Neill R, Knopman, David, Rademakers, Rosa, Lemstra, Afina W, Pijnenburg, Yolande A L, Scheltens, Philip, Gasser, Thomas, Chinnery, Patrick F, Hemmer, Bernhard, Chen, Jason A, Huisman, Martijn A, Troncoso, Juan, Moreno, Fermin, Nohr, Ellen A, Sørensen, Thorkild I A, Heutink, Peter, Sánchez-Juan, Pascual, Posthuma, Danielle, GIFT, and Clarimón, Jordi

Subjects
0301 basic medicine, Dementia with Lewy bodies, Disease, Bioinformatics, Neurodegenerative disease, 0302 clinical medicine, Missense mutation, media_common, 2. Zero hunger, Longevity, Brain, Parkinson Disease, Phospholipase C Gamma 2, Biobank, 3. Good health, ddc, Frontotemporal Dementia, Microglia, Alzheimer's disease, Alzheimer’s disease, Amyotrophic lateral sclerosis, Frontotemporal dementia, Multiple sclerosis, PLCG2, Parkinson’s disease, Progressive supranuclear palsy, Lewy Body Disease, Risk, Multiple Sclerosis, media_common.quotation_subject, education, Neuroimaging, Genomics, Pathology and Forensic Medicine, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Alzheimer Disease, medicine, Humans, Genetic Predisposition to Disease, ddc:610, Alleles, Phospholipase C gamma, business.industry, Amyotrophic Lateral Sclerosis, Correction, medicine.disease, 030104 developmental biology, Mutation, Dementia, Neurology (clinical), business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target. The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.

Published
2019

33. A meta-analysis of genome-wide association studies identifies multiple longevity genes

Author

Deelen, Joris, primary, Evans, Daniel S., additional, Arking, Dan E., additional, Tesi, Niccolò, additional, Nygaard, Marianne, additional, Liu, Xiaomin, additional, Wojczynski, Mary K., additional, Biggs, Mary L., additional, van der Spek, Ashley, additional, Atzmon, Gil, additional, Ware, Erin B., additional, Sarnowski, Chloé, additional, Smith, Albert V., additional, Seppälä, Ilkka, additional, Cordell, Heather J., additional, Dose, Janina, additional, Amin, Najaf, additional, Arnold, Alice M., additional, Ayers, Kristin L., additional, Barzilai, Nir, additional, Becker, Elizabeth J., additional, Beekman, Marian, additional, Blanché, Hélène, additional, Christensen, Kaare, additional, Christiansen, Lene, additional, Collerton, Joanna C., additional, Cubaynes, Sarah, additional, Cummings, Steven R., additional, Davies, Karen, additional, Debrabant, Birgit, additional, Deleuze, Jean-François, additional, Duncan, Rachel, additional, Faul, Jessica D., additional, Franceschi, Claudio, additional, Galan, Pilar, additional, Gudnason, Vilmundur, additional, Harris, Tamara B., additional, Huisman, Martijn, additional, Hurme, Mikko A., additional, Jagger, Carol, additional, Jansen, Iris, additional, Jylhä, Marja, additional, Kähönen, Mika, additional, Karasik, David, additional, Kardia, Sharon L. R., additional, Kingston, Andrew, additional, Kirkwood, Thomas B. L., additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lyytikäinen, Leo-Pekka, additional, Martin-Ruiz, Carmen, additional, Min, Junxia, additional, Nebel, Almut, additional, Newman, Anne B., additional, Nie, Chao, additional, Nohr, Ellen A., additional, Orwoll, Eric S., additional, Perls, Thomas T., additional, Province, Michael A., additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Reinders, Marcel J. T., additional, Robine, Jean-Marie, additional, Rotter, Jerome I., additional, Sebastiani, Paola, additional, Smith, Jennifer, additional, Sørensen, Thorkild I. A., additional, Taylor, Kent D., additional, Uitterlinden, André G., additional, van der Flier, Wiesje, additional, van der Lee, Sven J., additional, van Duijn, Cornelia M., additional, van Heemst, Diana, additional, Vaupel, James W., additional, Weir, David, additional, Ye, Kenny, additional, Zeng, Yi, additional, Zheng, Wanlin, additional, Holstege, Henne, additional, Kiel, Douglas P., additional, Lunetta, Kathryn L., additional, Slagboom, P. Eline, additional, and Murabito, Joanne M., additional

Published
2019
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35. Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Author

Lees, John A., primary, Ferwerda, Bart, additional, Kremer, Philip H. C., additional, Wheeler, Nicole E., additional, Serón, Mercedes Valls, additional, Croucher, Nicholas J., additional, Gladstone, Rebecca A., additional, Bootsma, Hester J., additional, Rots, Nynke Y., additional, Wijmega-Monsuur, Alienke J., additional, Sanders, Elisabeth A. M., additional, Trzciński, Krzysztof, additional, Wyllie, Anne L., additional, Zwinderman, Aeilko H., additional, van den Berg, Leonard H., additional, van Rheenen, Wouter, additional, Veldink, Jan H., additional, Harboe, Zitta B., additional, Lundbo, Lene F., additional, de Groot, Lisette C. P. G. M., additional, van Schoor, Natasja M., additional, van der Velde, Nathalie, additional, Ängquist, Lars H., additional, Sørensen, Thorkild I. A., additional, Nohr, Ellen A., additional, Mentzer, Alexander J., additional, Mills, Tara C., additional, Knight, Julian C., additional, du Plessis, Mignon, additional, Nzenze, Susan, additional, Weiser, Jeffrey N., additional, Parkhill, Julian, additional, Madhi, Shabir, additional, Benfield, Thomas, additional, von Gottberg, Anne, additional, van der Ende, Arie, additional, Brouwer, Matthijs C., additional, Barrett, Jeffrey C., additional, Bentley, Stephen D., additional, and van de Beek, Diederik, additional

Published
2019
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36. Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Author

Küpers, Leanne K., primary, Monnereau, Claire, additional, Sharp, Gemma C., additional, Yousefi, Paul, additional, Salas, Lucas A., additional, Ghantous, Akram, additional, Page, Christian M., additional, Reese, Sarah E., additional, Wilcox, Allen J., additional, Czamara, Darina, additional, Starling, Anne P., additional, Novoloaca, Alexei, additional, Lent, Samantha, additional, Roy, Ritu, additional, Hoyo, Cathrine, additional, Breton, Carrie V., additional, Allard, Catherine, additional, Just, Allan C., additional, Bakulski, Kelly M., additional, Holloway, John W., additional, Everson, Todd M., additional, Xu, Cheng-Jian, additional, Huang, Rae-Chi, additional, van der Plaat, Diana A., additional, Wielscher, Matthias, additional, Merid, Simon Kebede, additional, Ullemar, Vilhelmina, additional, Rezwan, Faisal I., additional, Lahti, Jari, additional, van Dongen, Jenny, additional, Langie, Sabine A. S., additional, Richardson, Tom G., additional, Magnus, Maria C., additional, Nohr, Ellen A., additional, Xu, Zongli, additional, Duijts, Liesbeth, additional, Zhao, Shanshan, additional, Zhang, Weiming, additional, Plusquin, Michelle, additional, DeMeo, Dawn L., additional, Solomon, Olivia, additional, Heimovaara, Joosje H., additional, Jima, Dereje D., additional, Gao, Lu, additional, Bustamante, Mariona, additional, Perron, Patrice, additional, Wright, Robert O., additional, Hertz-Picciotto, Irva, additional, Zhang, Hongmei, additional, Karagas, Margaret R., additional, Gehring, Ulrike, additional, Marsit, Carmen J., additional, Beilin, Lawrence J., additional, Vonk, Judith M., additional, Jarvelin, Marjo-Riitta, additional, Bergström, Anna, additional, Örtqvist, Anne K., additional, Ewart, Susan, additional, Villa, Pia M., additional, Moore, Sophie E., additional, Willemsen, Gonneke, additional, Standaert, Arnout R. L., additional, Håberg, Siri E., additional, Sørensen, Thorkild I. A., additional, Taylor, Jack A., additional, Räikkönen, Katri, additional, Yang, Ivana V., additional, Kechris, Katerina, additional, Nawrot, Tim S., additional, Silver, Matt J., additional, Gong, Yun Yun, additional, Richiardi, Lorenzo, additional, Kogevinas, Manolis, additional, Litonjua, Augusto A., additional, Eskenazi, Brenda, additional, Huen, Karen, additional, Mbarek, Hamdi, additional, Maguire, Rachel L., additional, Dwyer, Terence, additional, Vrijheid, Martine, additional, Bouchard, Luigi, additional, Baccarelli, Andrea A., additional, Croen, Lisa A., additional, Karmaus, Wilfried, additional, Anderson, Denise, additional, de Vries, Maaike, additional, Sebert, Sylvain, additional, Kere, Juha, additional, Karlsson, Robert, additional, Arshad, Syed Hasan, additional, Hämäläinen, Esa, additional, Routledge, Michael N., additional, Boomsma, Dorret I., additional, Feinberg, Andrew P., additional, Newschaffer, Craig J., additional, Govarts, Eva, additional, Moisse, Matthieu, additional, Fallin, M. Daniele, additional, Melén, Erik, additional, Prentice, Andrew M., additional, Kajantie, Eero, additional, Almqvist, Catarina, additional, Oken, Emily, additional, Dabelea, Dana, additional, Boezen, H. Marike, additional, Melton, Phillip E., additional, Wright, Rosalind J., additional, Koppelman, Gerard H., additional, Trevisi, Letizia, additional, Hivert, Marie-France, additional, Sunyer, Jordi, additional, Munthe-Kaas, Monica C., additional, Murphy, Susan K., additional, Corpeleijn, Eva, additional, Wiemels, Joseph, additional, Holland, Nina, additional, Herceg, Zdenko, additional, Binder, Elisabeth B., additional, Davey Smith, George, additional, Jaddoe, Vincent W. V., additional, Lie, Rolv T., additional, Nystad, Wenche, additional, London, Stephanie J., additional, Lawlor, Debbie A., additional, Relton, Caroline L., additional, Snieder, Harold, additional, and Felix, Janine F., additional

Published
2019
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38. Genetic Determinants of Weight Loss After Bariatric Surgery

Author

Aasbrenn, Martin, primary, Schnurr, Theresia Maria, additional, Have, Christian Theil, additional, Svendstrup, Mathilde, additional, Hansen, Dorte Lindqvist, additional, Worm, Dorte, additional, Balslev-Harder, Marie, additional, Hollensted, Mette, additional, Grarup, Niels, additional, Burgdorf, Kristoffer Sølvsten, additional, Vestergaard, Henrik, additional, Pedersen, Oluf, additional, Sørensen, Thorkild I. A., additional, Fenger, Mogens, additional, Madsbad, Sten, additional, and Hansen, Torben, additional

Published
2019
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39. Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Author

Santos, Susana, primary, Eekhout, Iris, additional, Voerman, Ellis, additional, Gaillard, Romy, additional, Barros, Henrique, additional, Charles, Marie-Aline, additional, Chatzi, Leda, additional, Chevrier, Cécile, additional, Chrousos, George P., additional, Corpeleijn, Eva, additional, Costet, Nathalie, additional, Crozier, Sarah, additional, Doyon, Myriam, additional, Eggesbø, Merete, additional, Fantini, Maria Pia, additional, Farchi, Sara, additional, Forastiere, Francesco, additional, Gagliardi, Luigi, additional, Georgiu, Vagelis, additional, Godfrey, Keith M., additional, Gori, Davide, additional, Grote, Veit, additional, Hanke, Wojciech, additional, Hertz-Picciotto, Irva, additional, Heude, Barbara, additional, Hivert, Marie-France, additional, Hryhorczuk, Daniel, additional, Huang, Rae-Chi, additional, Inskip, Hazel, additional, Jusko, Todd A., additional, Karvonen, Anne M., additional, Koletzko, Berthold, additional, Küpers, Leanne K., additional, Lagström, Hanna, additional, Lawlor, Debbie A., additional, Lehmann, Irina, additional, Lopez-Espinosa, Maria-Jose, additional, Magnus, Per, additional, Majewska, Renata, additional, Mäkelä, Johanna, additional, Manios, Yannis, additional, McDonald, Sheila W., additional, Mommers, Monique, additional, Morgen, Camilla S., additional, Moschonis, George, additional, Murínová, Ľubica, additional, Newnham, John, additional, Nohr, Ellen A., additional, Andersen, Anne-Marie Nybo, additional, Oken, Emily, additional, Oostvogels, Adriëtte J. J. M., additional, Pac, Agnieszka, additional, Papadopoulou, Eleni, additional, Pekkanen, Juha, additional, Pizzi, Costanza, additional, Polanska, Kinga, additional, Porta, Daniela, additional, Richiardi, Lorenzo, additional, Rifas-Shiman, Sheryl L., additional, Roeleveld, Nel, additional, Santa-Marina, Loreto, additional, Santos, Ana C., additional, Smit, Henriette A., additional, Sørensen, Thorkild I. A., additional, Standl, Marie, additional, Stanislawski, Maggie, additional, Stoltenberg, Camilla, additional, Thiering, Elisabeth, additional, Thijs, Carel, additional, Torrent, Maties, additional, Tough, Suzanne C., additional, Trnovec, Tomas, additional, van Gelder, Marleen M. H. J., additional, van Rossem, Lenie, additional, von Berg, Andrea, additional, Vrijheid, Martine, additional, Vrijkotte, Tanja G. M., additional, Zvinchuk, Oleksandr, additional, van Buuren, Stef, additional, and Jaddoe, Vincent W. V., additional

Published
2018
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40. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium

Author

Merino, Jordi, primary, Dashti, Hassan S., additional, Li, Sherly X., additional, Sarnowski, Chloé, additional, Justice, Anne E., additional, Graff, Misa, additional, Papoutsakis, Constantina, additional, Smith, Caren E., additional, Dedoussis, George V., additional, Lemaitre, Rozenn N., additional, Wojczynski, Mary K., additional, Männistö, Satu, additional, Ngwa, Julius S., additional, Kho, Minjung, additional, Ahluwalia, Tarunveer S., additional, Pervjakova, Natalia, additional, Houston, Denise K., additional, Bouchard, Claude, additional, Huang, Tao, additional, Orho-Melander, Marju, additional, Frazier-Wood, Alexis C., additional, Mook-Kanamori, Dennis O., additional, Pérusse, Louis, additional, Pennell, Craig E., additional, de Vries, Paul S., additional, Voortman, Trudy, additional, Li, Olivia, additional, Kanoni, Stavroula, additional, Rose, Lynda M., additional, Lehtimäki, Terho, additional, Zhao, Jing Hua, additional, Feitosa, Mary F., additional, Luan, Jian’an, additional, McKeown, Nicola M., additional, Smith, Jennifer A., additional, Hansen, Torben, additional, Eklund, Niina, additional, Nalls, Mike A., additional, Rankinen, Tuomo, additional, Huang, Jinyan, additional, Hernandez, Dena G., additional, Schulz, Christina-Alexandra, additional, Manichaikul, Ani, additional, Li-Gao, Ruifang, additional, Vohl, Marie-Claude, additional, Wang, Carol A., additional, van Rooij, Frank J. A., additional, Shin, Jean, additional, Kalafati, Ioanna P., additional, Day, Felix, additional, Ridker, Paul M., additional, Kähönen, Mika, additional, Siscovick, David S., additional, Langenberg, Claudia, additional, Zhao, Wei, additional, Astrup, Arne, additional, Knekt, Paul, additional, Garcia, Melissa, additional, Rao, D. C., additional, Qi, Qibin, additional, Ferrucci, Luigi, additional, Ericson, Ulrika, additional, Blangero, John, additional, Hofman, Albert, additional, Pausova, Zdenka, additional, Mikkilä, Vera, additional, Wareham, Nick J., additional, Kardia, Sharon L. R, additional, Pedersen, Oluf, additional, Jula, Antti, additional, Curran, Joanne E., additional, Zillikens, M. Carola, additional, Viikari, Jorma S., additional, Forouhi, Nita G., additional, Ordovás, José M., additional, Lieske, John C., additional, Rissanen, Harri, additional, Uitterlinden, André G., additional, Raitakari, Olli T., additional, Kiefte-de Jong, Jessica C., additional, Dupuis, Josée, additional, Rotter, Jerome I., additional, North, Kari E., additional, Scott, Robert A., additional, Province, Michael A., additional, Perola, Markus, additional, Cupples, L. Adrienne, additional, Turner, Stephen T., additional, Sørensen, Thorkild I. A., additional, Salomaa, Veikko, additional, Liu, Yongmei, additional, Sung, Yun J., additional, Qi, Lu, additional, Bandinelli, Stefania, additional, Rich, Stephen S., additional, de Mutsert, Renée, additional, Tremblay, Angelo, additional, Oddy, Wendy H., additional, Franco, Oscar H., additional, Paus, Tomas, additional, Florez, Jose C., additional, Deloukas, Panos, additional, Lyytikäinen, Leo-Pekka, additional, Chasman, Daniel I., additional, Chu, Audrey Y., additional, and Tanaka, Toshiko, additional

Published
2018
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43. Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts

Author

Jelenkovic, Aline, primary, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Hur, Yoon-Mi, additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik KE, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, Beijsterveldt, Catharina EM van, additional, Bogl, Leonie H., additional, Pietiläinen, Kirsi H, additional, Vuoksimaa, Eero, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Nelson, Tracy L, additional, Whitfield, Keith E., additional, Rebato, Esther, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Ooki, Syuichi, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, Brescianini, Sonia, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Cutler, Tessa L, additional, Hopper, John L., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Haworth, Claire MA, additional, Plomin, Robert, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S Alexandra, additional, Klump, Kelly L., additional, Vlietinck, Robert F., additional, Derom, Catherine A., additional, Loos, Ruth JF, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2018
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47. Alcohol consumption and its interaction with adiposity-associated genetic variants in relation to subsequent changes in waist circumference and body weight

Author

Rohde, Jeanett F, primary, Ängquist, Lars, additional, Larsen, Sofus C., additional, Tolstrup, Janne S., additional, Husemoen, Lise Lotte N., additional, Linneberg, Allan, additional, Toft, Ulla, additional, Overvad, Kim, additional, Halkjær, Jytte, additional, Tjønneland, Anne, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Sørensen, Thorkild I. A., additional, and Heitmann, Berit L, additional

Published
2017
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49. Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

Author

Maretty, Lasse, primary, Jensen, Jacob Malte, additional, Petersen, Bent, additional, Sibbesen, Jonas Andreas, additional, Liu, Siyang, additional, Villesen, Palle, additional, Skov, Laurits, additional, Belling, Kirstine, additional, Theil Have, Christian, additional, Izarzugaza, Jose M. G., additional, Grosjean, Marie, additional, Bork-Jensen, Jette, additional, Grove, Jakob, additional, Als, Thomas D., additional, Huang, Shujia, additional, Chang, Yuqi, additional, Xu, Ruiqi, additional, Ye, Weijian, additional, Rao, Junhua, additional, Guo, Xiaosen, additional, Sun, Jihua, additional, Cao, Hongzhi, additional, Ye, Chen, additional, van Beusekom, Johan, additional, Espeseth, Thomas, additional, Flindt, Esben, additional, Friborg, Rune M., additional, Halager, Anders E., additional, Le Hellard, Stephanie, additional, Hultman, Christina M., additional, Lescai, Francesco, additional, Li, Shengting, additional, Lund, Ole, additional, Løngren, Peter, additional, Mailund, Thomas, additional, Matey-Hernandez, Maria Luisa, additional, Mors, Ole, additional, Pedersen, Christian N. S., additional, Sicheritz-Pontén, Thomas, additional, Sullivan, Patrick, additional, Syed, Ali, additional, Westergaard, David, additional, Yadav, Rachita, additional, Li, Ning, additional, Xu, Xun, additional, Hansen, Torben, additional, Krogh, Anders, additional, Bolund, Lars, additional, Sørensen, Thorkild I. A., additional, Pedersen, Oluf, additional, Gupta, Ramneek, additional, Rasmussen, Simon, additional, Besenbacher, Søren, additional, Børglum, Anders D., additional, Wang, Jun, additional, Eiberg, Hans, additional, Kristiansen, Karsten, additional, Brunak, Søren, additional, and Schierup, Mikkel Heide, additional

Published
2017
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50. Does the sex of one’s co-twin affect height and BMI in adulthood? A study of dizygotic adult twins from 31 cohorts

Author

Bogl, Leonie H., primary, Jelenkovic, Aline, additional, Vuoksimaa, Eero, additional, Ahrenfeldt, Linda, additional, Pietiläinen, Kirsi H., additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Hur, Yoon-Mi, additional, Jeong, Hoe-Uk, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Cutler, Tessa L., additional, Kandler, Christian, additional, Jang, Kerry L., additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Pang, Zengchang, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Hjelmborg, Jacob v. B., additional, Rebato, Esther, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Busjahn, Andreas, additional, Lichtenstein, Paul, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Yokoyama, Yoshie, additional, Hopper, John L., additional, Loos, Ruth J. F., additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Silventoinen, Karri, additional, and Kaprio, Jaakko, additional

Published
2017
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