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1. Neanderthal introgression in SCN9A impacts mechanical pain sensitivity

Author

Faux, Pierre, primary, Ding, Li, additional, Ramirez-Aristeguieta, Luis Miguel, additional, Chacón-Duque, J. Camilo, additional, Comini, Maddalena, additional, Mendoza-Revilla, Javier, additional, Fuentes-Guajardo, Macarena, additional, Jaramillo, Claudia, additional, Arias, William, additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Barquera, Rodrigo, additional, Everardo-Martínez, Paola, additional, Quinto-Sánchez, Mirsha, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Silva de Cerqueira, Caio C., additional, Hünemeier, Tábita, additional, Ramallo, Virginia, additional, Gonzalez-José, Rolando, additional, Schüler-Faccini, Lavinia, additional, Bortolini, Maria-Cátira, additional, Acuña-Alonzo, Victor, additional, Canizales-Quinteros, Samuel, additional, Poletti, Giovanni, additional, Gallo, Carla, additional, Rothhammer, Francisco, additional, Rojas, Winston, additional, Schmid, Annina B., additional, Adhikari, Kaustubh, additional, Bennett, David L., additional, and Ruiz-Linares, Andrés, additional

Published
2023
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2. Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Author

Li, Qing, primary, Chen, Jieyi, additional, Faux, Pierre, additional, Delgado, Miguel Eduardo, additional, Bonfante, Betty, additional, Fuentes-Guajardo, Macarena, additional, Mendoza-Revilla, Javier, additional, Chacón-Duque, J. Camilo, additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Jaramillo, Claudia, additional, Arias, William, additional, Barquera, Rodrigo, additional, Everardo-Martínez, Paola, additional, Sánchez-Quinto, Mirsha, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Silva de Cerqueira, Caio C., additional, Hünemeier, Tábita, additional, Ramallo, Virginia, additional, Wu, Sijie, additional, Du, Siyuan, additional, Giardina, Andrea, additional, Paria, Soumya Subhra, additional, Khokan, Mahfuzur Rahman, additional, Gonzalez-José, Rolando, additional, Schüler-Faccini, Lavinia, additional, Bortolini, Maria-Cátira, additional, Acuña-Alonzo, Victor, additional, Canizales-Quinteros, Samuel, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Rojas, Winston, additional, Rothhammer, Francisco, additional, Navarro, Nicolas, additional, Wang, Sijia, additional, Adhikari, Kaustubh, additional, and Ruiz-Linares, Andrés, additional

Published
2023
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3. Automatic landmarking identifies new loci associated with face morphology and implicates Neanderthal introgression in human nasal shape

Author

Qing Li, Jieyi Chen, Pierre Faux, Miguel Eduardo Delgado, Betty Bonfante, Macarena Fuentes-Guajardo, Javier Mendoza-Revilla, J. Camilo Chacón-Duque, Malena Hurtado, Valeria Villegas, Vanessa Granja, Claudia Jaramillo, William Arias, Rodrigo Barquera, Paola Everardo-Martínez, Mirsha Sánchez-Quinto, Jorge Gómez-Valdés, Hugo Villamil-Ramírez, Caio C. Silva de Cerqueira, Tábita Hünemeier, Virginia Ramallo, Sijie Wu, Siyuan Du, Andrea Giardina, Soumya Subhra Paria, Mahfuzur Rahman Khokan, Rolando Gonzalez-José, Lavinia Schüler-Faccini, Maria-Cátira Bortolini, Victor Acuña-Alonzo, Samuel Canizales-Quinteros, Carla Gallo, Giovanni Poletti, Winston Rojas, Francisco Rothhammer, Nicolas Navarro, Sijia Wang, Kaustubh Adhikari, Andrés Ruiz-Linares, Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University [Shanghai]-Collaborative Innovation Center for Genetics and Development, CAS Key Laboratory of Computational Biology, Chinese Academy of Sciences [Beijing] (CAS)-University of Chinese Academy of Sciences [Beijing] (UCAS)-Shanghai Institute of Nutrition and Health, Anthropologie bio-culturelle, Droit, Ethique et Santé (ADES), Aix Marseille Université (AMU)-EFS ALPES MEDITERRANEE-Centre National de la Recherche Scientifique (CNRS), División Antropología [La Plata] (DA), Facultad de Ciencias Naturales y Museo [La Plata] (FCNyM), Universidad Nacional de la Plata [Argentine] (UNLP)-Universidad Nacional de la Plata [Argentine] (UNLP), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Departamento de Tecnología Médica, Universidad de Tarapaca, Laboratorios de Investigación y Desarrollo (LID), Universidad Peruana Cayetano Heredia (UPCH), Génétique Evolutive Humaine - Human Evolutionary Genetics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Division of Vertebrates and Anthropology, The Natural History Museum [London] (NHM), Laboratorio de Genética Molecular, Universidad de Antioquia = University of Antioquia [Medellín, Colombia], Molecular Genetics Laboratory, National School of Anthropology and History [Mexico City, Mexico] (NSAH), Department of Archaeogenetics [Jena] (DAG), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Forensic Science, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), Unidad de Genomica de Poblaciones Aplicada a la Salud, Scientific Police of São Paulo State [Ourinhos, Brazil], Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo = University of São Paulo (USP), Departamento de Genética, Universidade Federal do Rio Grande do Sul [Porto Alegre] (UFRGS), Instituto Patagónico de Ciencias Sociales y Humanas, School of Mathematics and Statistics [Milton Keynes], Faculty of Science, Technology, Engineering and Mathematics [Milton Keynes], The Open University [Milton Keynes] (OU)-The Open University [Milton Keynes] (OU), Facultad de Medicina & Instituto de Alta Investigacion, Universidad de Tarapaca-Universidade de Chile, Biogéosciences [UMR 6282] (BGS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL), Centre for Biodiversity and Environment Research, Department of Genetics, Evolution and Environment, University College of London [London] (UCL), the National Natural Science Foundation of China (#31771393), the Scientific and Technology Committee of Shanghai Municipality (18490750300), Ministry of Science and Technology of China (2020YFE0201600), Shanghai Municipal Science and Technology Major Project (2017SHZDZX01) and the 111 Project (B13016), the Leverhulme Trust (F/07 134/DF), BBSRC (BB/I021213/1), Universidad de Antioquia (CODI sostenibilidad de grupos 2013- 2014 and MASO 2013-2014), Conselho Nacional de Desenvolvimento Científico e Tecnológico, Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (Apoio a Núcleos de Excelência Program), Fundação de Aperfeiçoamento de Pessoal de Nível Superior and the National Institute of Dental and Craniofacial Research (R01-DE027023, U01-DE020078, R01-DE016148, X01-HG007821), Santander Research & Scholarship Award. B.B. is supported by a doctoral scholarship from Ecole Doctorale 251 Aix-Marseille Université., and ANR-11-IDEX-0001,Amidex,INITIATIVE D'EXCELLENCE AIX MARSEILLE UNIVERSITE(2011)

Subjects
MESH: Neanderthals, MESH: Cell Differentiation, MESH: Humans, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE], [SHS.ANTHRO-BIO]Humanities and Social Sciences/Biological anthropology, MESH: Nose, Medicine (miscellaneous), Sitios de Carácter Cuantitativo, Quantitative trait, Genome-wide association studies, General Biochemistry, Genetics and Molecular Biology, Estudio de Asociación del Genoma Completo, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, MESH: Genome-Wide Association Study, MESH: Animals, General Agricultural and Biological Sciences, MESH: Mice
Abstract

e report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking of 2D portraits and testing for association with inter-landmark distances. We detected significant associations (P-value

Published
2023

5. L-arginine-containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria

Author

López-Ruiz, Marta, primary, Navas, Francisco, additional, Fernández-García, Paloma, additional, Martínez-Erro, Samuel, additional, Fuentes, Mª Victoria, additional, Giráldez, Isabel, additional, Ceballos, Laura, additional, Ferrer-Luque, Carmen Mª, additional, Ruiz-Linares, Matilde, additional, Morales, Victoria, additional, Sanz, Raúl, additional, and García-Muñoz, Rafael A., additional

Published
2022
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6. L-arginine-containing mesoporous silica nanoparticles embedded in dental adhesive (Arg@MSN@DAdh) for targeting cariogenic bacteria

Author

Marta López-Ruiz, Francisco Navas, Paloma Fernández-García, Samuel Martínez-Erro, Mª Victoria Fuentes, Isabel Giráldez, Laura Ceballos, Carmen Mª Ferrer-Luque, Matilde Ruiz-Linares, Victoria Morales, Raúl Sanz, and Rafael A. García-Muñoz

Subjects
Streptococcus mutans, Biomedical Engineering, Humans, Nanoparticles, Dental Cements, Pharmaceutical Science, Molecular Medicine, Medicine (miscellaneous), Bioengineering, Dental Caries, Silicon Dioxide, Arginine, Applied Microbiology and Biotechnology
Abstract

Dental caries is the major biofilm-mediated oral disease in the world. The main treatment to restore caries lesions consists of the use of adhesive resin composites due to their good properties. However, the progressive degradation of the adhesive in the medium term makes possible the proliferation of cariogenic bacteria allowing secondary caries to emerge. In this study, a dental adhesive incorporating a drug delivery system based on L-arginine-containing mesoporous silica nanoparticles (MSNs) was used to release this essential amino acid as a source of basicity to neutralize the harmful acidic conditions that mediate the development of dental secondary caries. The in vitro and bacterial culture experiments proved that L-arginine was released in a sustained way from MSNs and diffused out from the dental adhesive, effectively contributing to the reduction of the bacterial strains Streptococcus mutans and Lactobacillus casei. Furthermore, the mechanical and bonding properties of the dental adhesive did not change significantly after the incorporation of L-arginine-containing MSNs. These results are yielding glimmers of promise for the cost-effective prevention of secondary caries. Graphical Abstract

Published
2022

7. Genetic variants underlying differences in facial morphology in East Asian and European populations

Author

Zhang, Manfei, primary, Wu, Sijie, additional, Du, Siyuan, additional, Qian, Wei, additional, Chen, Jieyi, additional, Qiao, Lu, additional, Yang, Yajun, additional, Tan, Jingze, additional, Yuan, Ziyu, additional, Peng, Qianqian, additional, Liu, Yu, additional, Navarro, Nicolas, additional, Tang, Kun, additional, Ruiz-Linares, Andrés, additional, Wang, Jiucun, additional, Claes, Peter, additional, Jin, Li, additional, Li, Jiarui, additional, and Wang, Sijia, additional

Published
2022
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9. RNASEH1 gene variants are associated with autoimmune type 1 diabetes in Colombia

Author

Andres Ruiz-Linares, Rivera A, Juan-Manuel Alfaro, Astrid J. Rodriguez-Acevedo, Alejandra Marcela Rodríguez, Gabriel Bedoya, Nicolas Pineda-Trujillo, and Ruiz-Linares, Andres

Subjects
Adult, Male, 0301 basic medicine, Candidate gene, Linkage disequilibrium, Endocrinology, Diabetes and Metabolism, Ribonuclease H, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Colombia, Biology, Polymorphism, Single Nucleotide, Linkage Disequilibrium, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Gene Frequency, Polymorphism (computer science), Humans, SNP, Family, Genetic Predisposition to Disease, Child, Allele frequency, ComputingMilieux_MISCELLANEOUS, Genetic Association Studies, Genetics, Haplotype, Chromosome, [SDV] Life Sciences [q-bio], Diabetes Mellitus, Type 1, 030104 developmental biology, Haplotypes, Female, Polymorphism, Restriction Fragment Length
Abstract

In a previous work, we found linkage and association of type 1 diabetes (T1D) to a 12 known gene region at chromosome 2p25 in Colombian families. Here, we present further work on this candidate region. Seventeen SNPs located on the 12 candidate genes, in 100 familial trios set, were tested by ARMS–tetraprimer–PCR or PCR–RFLP. Five extra SNPs in the vicinity of rs10186193 were typed. A replica phase included 97 novel familial trios, in whom diabetes-related auto-antibodies (AABs) were tested in sera of the patients. In addition to transmission disequilibrium tests, haplotype analyses were carried out using the unphased software. SNP rs10186193 (at RNASEH1 gene) showed association with T1D (P = 0.005). The additional five SNPs revealed that rs7607888 (P = 2.03 × 10−7), rs55981318 (P = 0.018), and rs1136545 (P = 1.93 × 10−9) were also associated with T1D. Haplotype analysis showed association for rs55981318–rs10186193 (P = 0.0005), rs7563960–rs7607888 (P = 0.0007), rs7607888–rs1136545 (P = 9.21 × 10−10), and rs1136545–rs11538545 (P = 6.67 × 10−8). In contrast, the new set of 97 familial trios tested for SNPs rs55981318, rs10186193, and rs7607888 did not support the previous finding; however, by combining the sample (197 trios), evidence of association of T1D with rs55981318 and rs7607888 was conclusive. In addition, a two-loci haplotype analysis of the combined sample showed significant association of RNASEH1 with T1D (P = 3.1 × 10−5). In conclusion, our analyses suggest that RNASEH1 gene variants associate with susceptibility/protection to T1D in Colombia.

Published
2017

10. The impact of socioeconomic and phenotypic traits on self-perception of ethnicity in Latin America

Author

Paschetta, Carolina, primary, de Azevedo, Soledad, additional, Ramallo, Virginia, additional, Cintas, Celia, additional, Pérez, Orlando, additional, Navarro, Pablo, additional, Bandieri, Lucas, additional, Sánchez, Mirsha Quinto, additional, Adhikari, Kaustubh, additional, Bortolini, M. Catira, additional, Ferrara, Giovanni Poletti, additional, Gallo, Carla, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Alonzo, Victor Acuña, additional, Ruiz-Linares, Andrés, additional, and González-José, Rolando, additional

Published
2021
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11. Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

Author

Romero-Hidalgo, Sandra, primary, Flores-Rivera, José, additional, Rivas-Alonso, Verónica, additional, Barquera, Rodrigo, additional, Villarreal-Molina, María Teresa, additional, Antuna-Puente, Bárbara, additional, Macias-Kauffer, Luis Rodrigo, additional, Villalobos-Comparán, Marisela, additional, Ortiz-Maldonado, Jair, additional, Yu, Neng, additional, Lebedeva, Tatiana V., additional, Alosco, Sharon M., additional, García-Rodríguez, Juan Daniel, additional, González-Torres, Carolina, additional, Rosas-Madrigal, Sandra, additional, Ordoñez, Graciela, additional, Guerrero-Camacho, Jorge Luis, additional, Treviño-Frenk, Irene, additional, Escamilla-Tilch, Monica, additional, García-Lechuga, Maricela, additional, Tovar-Méndez, Víctor Hugo, additional, Pacheco-Ubaldo, Hanna, additional, Acuña-Alonzo, Victor, additional, Bortolini, Maria-Cátira, additional, Gallo, Carla, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, González-Jose, Rolando, additional, Ruiz-Linares, Andrés, additional, Canizales-Quinteros, Samuel, additional, Yunis, Edmond, additional, Granados, Julio, additional, and Corona, Teresa, additional

Published
2020
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12. Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder

Author

Fears, Scott C., primary, Service, Susan K., additional, Kremeyer, Barbara, additional, Araya, Carmen, additional, Araya, Xinia, additional, Bejarano, Julio, additional, Ramirez, Margarita, additional, Castrillón, Gabriel, additional, Gomez-Franco, Juliana, additional, Lopez, Maria C., additional, Montoya, Gabriel, additional, Montoya, Patricia, additional, Aldana, Ileana, additional, Teshiba, Terri M., additional, Al-Sharif, Noor B., additional, Jalbrzikowski, Maria, additional, Tishler, Todd A., additional, Escobar, Javier, additional, Ruiz-Linares, Andrés, additional, Lopez-Jaramillo, Carlos, additional, Macaya, Gabriel, additional, Molina, Julio, additional, Reus, Victor I., additional, Cantor, Rita M., additional, Sabatti, Chiara, additional, Freimer, Nelson B., additional, and Bearden, Carrie E., additional

Published
2020
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13. Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

Author

Sul, Jae Hoon, primary, Service, Susan K., additional, Huang, Alden Y., additional, Ramensky, Vasily, additional, Hwang, Sun-Goo, additional, Teshiba, Terri M., additional, Park, YoungJun, additional, Ori, Anil P. S., additional, Zhang, Zhongyang, additional, Mullins, Niamh, additional, Olde Loohuis, Loes M., additional, Fears, Scott C., additional, Araya, Carmen, additional, Araya, Xinia, additional, Spesny, Mitzi, additional, Bejarano, Julio, additional, Ramirez, Margarita, additional, Castrillón, Gabriel, additional, Gomez-Makhinson, Juliana, additional, Lopez, Maria C., additional, Montoya, Gabriel, additional, Montoya, Claudia P., additional, Aldana, Ileana, additional, Escobar, Javier I., additional, Ospina-Duque, Jorge, additional, Kremeyer, Barbara, additional, Bedoya, Gabriel, additional, Ruiz-Linares, Andres, additional, Cantor, Rita M., additional, Molina, Julio, additional, Coppola, Giovanni, additional, Ophoff, Roel A., additional, Macaya, Gabriel, additional, Lopez-Jaramillo, Carlos, additional, Reus, Victor, additional, Bearden, Carrie E., additional, Sabatti, Chiara, additional, and Freimer, Nelson B., additional

Published
2020
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14. When is the Naive Bayes approximation not so naive?

Author

Ana Ruiz Linares, Christopher R. Stephens, and Hugo Flores Huerta

Subjects
business.industry, Generalization, 02 engineering and technology, Bayes classifier, Machine learning, computer.software_genre, Naive Bayes classifier, Artificial Intelligence, 020204 information systems, Phenomenon, 0202 electrical engineering, electronic engineering, information engineering, Performance prediction, A priori and a posteriori, Bayes error rate, 020201 artificial intelligence & image processing, Artificial intelligence, business, Classifier (UML), computer, Software, Mathematics
Abstract

The Naive Bayes approximation (NBA) and associated classifier are widely used and offer robust performance across a large spectrum of problem domains. As it depends on a very strong assumption--independence among features--this has been somewhat puzzling. Various hypotheses have been put forward to explain its success and many generalizations have been proposed. In this paper we propose a set of "local" error measures--associated with the likelihood functions for subsets of attributes and for each class--and show explicitly how these local errors combine to give a "global" error associated to the full attribute set. By so doing we formulate a framework within which the phenomenon of error cancelation, or augmentation, can be quantified and its impact on classifier performance estimated and predicted a priori. These diagnostics allow us to develop a deeper and more quantitative understanding of why the NBA is so robust and under what circumstances one expects it to break down. We show how these diagnostics can be used to select which features to combine and use them in a simple generalization of the NBA, applying the resulting classifier to a set of real world data sets.

Published
2017

15. A GWAS in Latin Americans highlights the convergent evolution of lighter skin pigmentation in Eurasia

Author

Adhikari, Kaustubh, primary, Mendoza-Revilla, Javier, additional, Sohail, Anood, additional, Fuentes-Guajardo, Macarena, additional, Lampert, Jodie, additional, Chacón-Duque, Juan Camilo, additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Lozano, Rodrigo Barquera, additional, Everardo, Paola, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Silva de Cerqueira, Caio C., additional, Hunemeier, Tábita, additional, Ramallo, Virginia, additional, Schuler-Faccini, Lavinia, additional, Salzano, Francisco M., additional, Gonzalez-José, Rolando, additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Tobin, Desmond J., additional, Fumagalli, Matteo, additional, Balding, David, additional, and Ruiz-Linares, Andrés, additional

Published
2019
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16. Latin Americans show wide-spread Converso ancestry and imprint of local Native ancestry on physical appearance

Author

Chacón-Duque, Juan-Camilo, primary, Adhikari, Kaustubh, additional, Fuentes-Guajardo, Macarena, additional, Mendoza-Revilla, Javier, additional, Acuña-Alonzo, Victor, additional, Barquera, Rodrigo, additional, Quinto-Sánchez, Mirsha, additional, Gómez-Valdés, Jorge, additional, Everardo Martínez, Paola, additional, Villamil-Ramírez, Hugo, additional, Hünemeier, Tábita, additional, Ramallo, Virginia, additional, Silva de Cerqueira, Caio C., additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Villena, Mercedes, additional, Vásquez, René, additional, Llop, Elena, additional, Sandoval, José R., additional, Salazar-Granara, Alberto A., additional, Parolin, Maria-Laura, additional, Sandoval, Karla, additional, Peñaloza-Espinosa, Rosenda I., additional, Rangel-Villalobos, Hector, additional, Winkler, Cheryl A., additional, Klitz, William, additional, Bravi, Claudio, additional, Molina, Julio, additional, Corach, Daniel, additional, Barrantes, Ramiro, additional, Gomes, Verónica, additional, Resende, Carlos, additional, Gusmão, Leonor, additional, Amorim, Antonio, additional, Xue, Yali, additional, Dugoujon, Jean-Michel, additional, Moral, Pedro, additional, González-José, Rolando, additional, Schuler-Faccini, Lavinia, additional, Salzano, Francisco M., additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Poletti, Giovanni, additional, Gallo, Carla, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Balding, David, additional, Hellenthal, Garrett, additional, and Ruiz-Linares, Andrés, additional

Published
2018
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17. Residual activity of cetrimide and chlorhexidine on Enterococcus faecalis-infected root canals

Author

Matilde Ruiz-Linares, Pilar Baca, María Elena Martínez García, María Teresa Arias-Moliz, and Carmen María Ferrer-Luque

Subjects
Time Factors, medicine.drug_class, Root canal, Cetrimide, final irrigation, Bacterial growth, Enterococcus faecalis, Microbiology, Antiseptic, antimicrobial effects, Humans, Medicine, General Dentistry, Edetic Acid, Gram-Positive Bacterial Infections, Root Canal Irrigants, biology, Cetrimonium, residual activity, business.industry, chlorhexidine, Chlorhexidine, cetrimide, Antimicrobial, biology.organism_classification, Bacterial Load, medicine.anatomical_structure, Biofilms, Smear Layer, Anti-Infective Agents, Local, Cetrimonium Compounds, Microscopy, Electron, Scanning, Original Article, Dental Pulp Cavity, business, Root Canal Preparation, Bacteria, medicine.drug
Abstract

Effective final irrigation regimen is an important step in order to achieve better disinfection and ensure residual antimicrobial effects after root canal preparation. The aim of this study was to compare the residual antimicrobial activity of 0.2% cetrimide, and 0.2% and 2% chlorhexidine in root canals infected with Enterococcus faecalis. Biofilms of E. faecalis were grown on uniradicular roots for 4 weeks. After root canal preparation, root canals were irrigated with 17% ethylenediaminetetraacetic acid (EDTA) to remove the smear layer. The roots were randomly divided into three experimental groups (n=26) according to the final irrigating solution: Group I, 5 mL 0.2% cetrimide; Group II, 5 mL 0.2% chlorhexidine; and Group III, 5 mL 2% chlorhexidine. Samples were collected for 50 days to denote the presence of bacterial growth. The proportion of ungrown specimens over 50 days was evaluated using the nonparametric Kaplan–Meier survival analysis. Differences among groups were tested using the log-rank test and the level of statistical significance was set at P

Published
2013

18. Developmental pathways inferred from modularity, morphological integration and fluctuating asymmetry patterns in the human face

Author

Quinto-Sánchez, Mirsha, primary, Muñoz-Muñoz, Francesc, additional, Gomez-Valdes, Jorge, additional, Cintas, Celia, additional, Navarro, Pablo, additional, Cerqueira, Caio Cesar Silva de, additional, Paschetta, Carolina, additional, de Azevedo, Soledad, additional, Ramallo, Virginia, additional, Acuña-Alonzo, Victor, additional, Adhikari, Kaustubh, additional, Fuentes-Guajardo, Macarena, additional, Hünemeier, Tábita, additional, Everardo, Paola, additional, de Avila, Francisco, additional, Jaramillo, Claudia, additional, Arias, Williams, additional, Gallo, Carla, additional, Poletti, Giovani, additional, Bedoya, Gabriel, additional, Bortolini, Maria Cátira, additional, Canizales-Quinteros, Samuel, additional, Rothhammer, Francisco, additional, Rosique, Javier, additional, Ruiz-Linares, Andres, additional, and Gonzalez-Jose, Rolando, additional

Published
2018
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19. Ancestry variation and footprints of natural selection along the genome in Latin American populations

Author

Lian Deng, Sijia Wang, Shuhua Xu, and Andres Ruiz-Linares

Subjects
0301 basic medicine, Latin Americans, Black People, Genomics, Context (language use), Article, White People, 03 medical and health sciences, 0302 clinical medicine, Genetic drift, Humans, Computer Simulation, Selection, Genetic, Genetics, Multidisciplinary, Natural selection, Genome, Human, Genetic Drift, Haplotype, Chromosome Mapping, Europe, Genetics, Population, Latin America, 030104 developmental biology, Variation (linguistics), Geography, Haplotypes, Evolutionary biology, Africa, Indians, North American, Microsatellite, 030217 neurology & neurosurgery, Microsatellite Repeats
Abstract

Latin American populations stem from the admixture of Europeans, Africans and Native Americans, which started over 400 years ago and had lasted for several centuries. Extreme deviation over the genome-wide average in ancestry estimations at certain genomic locations could reflect recent natural selection. We evaluated the distribution of ancestry estimations using 678 genome-wide microsatellite markers in 249 individuals from 13 admixed populations across Latin America. We found significant deviations in ancestry estimations including three locations with more than 3.5 times standard deviations from the genome-wide average: an excess of European ancestry at 1p36 and 14q32, and an excess of African ancestry at 6p22. Using simulations, we could show that at least the deviation at 6p22 was unlikely to result from genetic drift alone. By applying different linguistic groups as well as the most likely ancestral Native American populations as the ancestry, we showed that the choice of Native American ancestry could affect the local ancestry estimation. However, the signal at 6p22 consistently appeared in most of the analyses using various ancestral groups. This study provided important insights for recent natural selection in the context of the unique history of the New World and implications for disease mapping.

Published
2016

20. Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Author

Natalia E. Poveda, Luis G. Leal, Diana Carolina Zuluaga Varón, Yessica Agudelo-Zapata, Adriana Castiblanco-Cortes, María Fernanda Garcés, Sergio Valderrama, Edith Ángel-Müller, Jorge E. Caminos, Carlos Dieguez, Héctor Fabio Sandoval-Alzate, Elizabeth Sanchez, Ariel Iván Ruiz-Parra, Angélica María González-Clavijo, Rubén Nogueiras, and Carlos E. Ruiz-Linares

Subjects
0301 basic medicine, Pregnancy, medicine.medical_specialty, Multidisciplinary, business.industry, Obstetrics, Leptin, media_common.quotation_subject, Adipose tissue, 030209 endocrinology & metabolism, medicine.disease, Article, Pathophysiology, Preeclampsia, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Metabolic control analysis, Medicine, Gestation, business, reproductive and urinary physiology, Menstrual cycle, media_common
Abstract

Adipsin is a protease produced at high levels by adipose tissue. It is involved in complement activation and metabolic control. The objective of this study was to determine the changes in adipsin levels during different stages of normal pregnancy and its association with obstetric outcomes, such as preeclampsia. This nested case-control study in a longitudinal cohort included normal pregnant (n = 54) and preeclamptic (n = 18) women, both followed throughout pregnancy. Additionally, some of the normal pregnant women were followed up three months postpartum (n = 18). Healthy non-pregnant women were also studied during their menstrual cycle (n = 20). The results of this study show that in healthy non-pregnant women, adipsin levels did not change significantly during the menstrual cycle. In normal pregnant women, adipsin levels were lower (p

Published
2016

21. Recessive distal renal tubular acidosis in Sarawak caused by AE1 mutations

Author

Taija K. Nicoli, Michael J. A. Tanner, Keng E. Choo, Lesley J. Bruce, O Wrong, and Andres Ruiz-Linares

Subjects
Male, Hemolytic anemia, Genes, Recessive, Biology, Compound heterozygosity, medicine.disease_cause, Distal renal tubular acidosis, Anion Exchange Protein 1, Erythrocyte, Diseases in Twins, medicine, Humans, Band 3, Gene, Genetics, Mutation, Red Cell, Infant, Newborn, Malaysia, Acidosis, Renal Tubular, medicine.disease, Southeast Asian ovalocytosis, Pedigree, Nephrology, Pediatrics, Perinatology and Child Health, biology.protein, Female
Abstract

Mutations of the AE1 (SLC4A1, Anion-Exchanger 1) gene that codes for band 3, the renal and red cell anion exchanger, are responsible for many cases of familial distal renal tubular acidosis (dRTA). In Southeast Asia this disease is usually recessive, caused either by homozygosity of a single AE1 mutation or by compound heterozygosity of two different AE1 mutations. We describe two unrelated boys in Sarawak with dRTA associated with compound heterozygosity of AE1 mutations. Both had Southeast Asian ovalocytosis (SAO), a morphological abnormality of red cells caused by a deletion of band 3 residues 400-408. In addition, one boy had a DNA sequence abnormality of band 3 residue (G701D), which has been reported from elsewhere in Southeast Asia. The other boy had the novel sequence abnormality of band 3 (Q759H) and profound hemolytic anemia.

Published
2005

22. The Simons Genome Diversity Project: 300 genomes from 142 diverse populations

Author

Mallick, Swapan, primary, Li, Heng, additional, Lipson, Mark, additional, Mathieson, Iain, additional, Gymrek, Melissa, additional, Racimo, Fernando, additional, Zhao, Mengyao, additional, Chennagiri, Niru, additional, Nordenfelt, Susanne, additional, Tandon, Arti, additional, Skoglund, Pontus, additional, Lazaridis, Iosif, additional, Sankararaman, Sriram, additional, Fu, Qiaomei, additional, Rohland, Nadin, additional, Renaud, Gabriel, additional, Erlich, Yaniv, additional, Willems, Thomas, additional, Gallo, Carla, additional, Spence, Jeffrey P., additional, Song, Yun S., additional, Poletti, Giovanni, additional, Balloux, Francois, additional, van Driem, George, additional, de Knijff, Peter, additional, Romero, Irene Gallego, additional, Jha, Aashish R., additional, Behar, Doron M., additional, Bravi, Claudio M., additional, Capelli, Cristian, additional, Hervig, Tor, additional, Moreno-Estrada, Andres, additional, Posukh, Olga L., additional, Balanovska, Elena, additional, Balanovsky, Oleg, additional, Karachanak-Yankova, Sena, additional, Sahakyan, Hovhannes, additional, Toncheva, Draga, additional, Yepiskoposyan, Levon, additional, Tyler-Smith, Chris, additional, Xue, Yali, additional, Abdullah, M. Syafiq, additional, Ruiz-Linares, Andres, additional, Beall, Cynthia M., additional, Di Rienzo, Anna, additional, Jeong, Choongwon, additional, Starikovskaya, Elena B., additional, Metspalu, Ene, additional, Parik, Jüri, additional, Villems, Richard, additional, Henn, Brenna M., additional, Hodoglugil, Ugur, additional, Mahley, Robert, additional, Sajantila, Antti, additional, Stamatoyannopoulos, George, additional, Wee, Joseph T. S., additional, Khusainova, Rita, additional, Khusnutdinova, Elza, additional, Litvinov, Sergey, additional, Ayodo, George, additional, Comas, David, additional, Hammer, Michael F., additional, Kivisild, Toomas, additional, Klitz, William, additional, Winkler, Cheryl A., additional, Labuda, Damian, additional, Bamshad, Michael, additional, Jorde, Lynn B., additional, Tishkoff, Sarah A., additional, Watkins, W. Scott, additional, Metspalu, Mait, additional, Dryomov, Stanislav, additional, Sukernik, Rem, additional, Singh, Lalji, additional, Thangaraj, Kumarasamy, additional, Pääbo, Svante, additional, Kelso, Janet, additional, Patterson, Nick, additional, and Reich, David, additional

Published
2016
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24. A genome-wide association scan implicates DCHS2, RUNX2, GLI3, PAX1 and EDAR in human facial variation

Author

Adhikari, Kaustubh, primary, Fuentes-Guajardo, Macarena, additional, Quinto-Sánchez, Mirsha, additional, Mendoza-Revilla, Javier, additional, Camilo Chacón-Duque, Juan, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Lozano, Rodrigo Barquera, additional, Pérez, Gastón Macín, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Hunemeier, Tábita, additional, Ramallo, Virginia, additional, Silva de Cerqueira, Caio C., additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Schuler-Faccini, Lavinia, additional, Salzano, Francisco M., additional, Bortolini, Maria- Cátira, additional, Canizales-Quinteros, Samuel, additional, Cheeseman, Michael, additional, Rosique, Javier, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Headon, Denis, additional, González-José, Rolando, additional, Balding, David, additional, and Ruiz-Linares, Andrés, additional

Published
2016
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25. A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features

Author

Adhikari, Kaustubh, primary, Fontanil, Tania, additional, Cal, Santiago, additional, Mendoza-Revilla, Javier, additional, Fuentes-Guajardo, Macarena, additional, Chacón-Duque, Juan-Camilo, additional, Al-Saadi, Farah, additional, Johansson, Jeanette A., additional, Quinto-Sanchez, Mirsha, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Barquera Lozano, Rodrigo, additional, Macín Pérez, Gastón, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Hunemeier, Tábita, additional, Ramallo, Virginia, additional, Silva de Cerqueira, Caio C., additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Schuler-Faccini, Lavinia, additional, Salzano, Francisco M., additional, Bortolini, Maria-Cátira, additional, Canizales-Quinteros, Samuel, additional, Rothhammer, Francisco, additional, Bedoya, Gabriel, additional, Gonzalez-José, Rolando, additional, Headon, Denis, additional, López-Otín, Carlos, additional, Tobin, Desmond J., additional, Balding, David, additional, and Ruiz-Linares, Andrés, additional

Published
2016
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27. Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia

Author

Poveda, Natalia E., primary, Garcés, María F., additional, Ruiz-Linares, Carlos E., additional, Varón, Diana, additional, Valderrama, Sergio, additional, Sanchez, Elizabeth, additional, Castiblanco-Cortes, Adriana, additional, Agudelo-Zapata, Yessica, additional, Sandoval-Alzate, Héctor Fabio, additional, Leal, Luis G., additional, Ángel-Müller, Edith, additional, Ruíz-Parra, Ariel I., additional, González-Clavijo, Angélica M., additional, Diéguez, Carlos, additional, Nogueiras, Rubén, additional, and Caminos, Jorge E., additional

Published
2016
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28. A genome-wide association study identifies multiple loci for variation in human ear morphology

Author

Adhikari, Kaustubh, primary, Reales, Guillermo, additional, Smith, Andrew J. P., additional, Konka, Esra, additional, Palmen, Jutta, additional, Quinto-Sanchez, Mirsha, additional, Acuña-Alonzo, Victor, additional, Jaramillo, Claudia, additional, Arias, William, additional, Fuentes, Macarena, additional, Pizarro, María, additional, Barquera Lozano, Rodrigo, additional, Macín Pérez, Gastón, additional, Gómez-Valdés, Jorge, additional, Villamil-Ramírez, Hugo, additional, Hunemeier, Tábita, additional, Ramallo, Virginia, additional, Silva de Cerqueira, Caio C., additional, Hurtado, Malena, additional, Villegas, Valeria, additional, Granja, Vanessa, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Schuler-Faccini, Lavinia, additional, Salzano, Francisco M., additional, Bortolini, Maria- Cátira, additional, Canizales-Quinteros, Samuel, additional, Rothhammer, Francisco, additional, Bedoya, Gabriel, additional, Calderón, Rosario, additional, Rosique, Javier, additional, Cheeseman, Michael, additional, Bhutta, Mahmood F., additional, Humphries, Steve E., additional, Gonzalez-José, Rolando, additional, Headon, Denis, additional, Balding, David, additional, and Ruiz-Linares, Andrés, additional

Published
2015
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30. Ancient human genomes suggest three ancestral populations for present-day Europeans

Author

Lazaridis, Iosif, primary, Patterson, Nick, additional, Mittnik, Alissa, additional, Renaud, Gabriel, additional, Mallick, Swapan, additional, Kirsanow, Karola, additional, Sudmant, Peter H., additional, Schraiber, Joshua G., additional, Castellano, Sergi, additional, Lipson, Mark, additional, Berger, Bonnie, additional, Economou, Christos, additional, Bollongino, Ruth, additional, Fu, Qiaomei, additional, Bos, Kirsten I., additional, Nordenfelt, Susanne, additional, Li, Heng, additional, de Filippo, Cesare, additional, Prüfer, Kay, additional, Sawyer, Susanna, additional, Posth, Cosimo, additional, Haak, Wolfgang, additional, Hallgren, Fredrik, additional, Fornander, Elin, additional, Rohland, Nadin, additional, Delsate, Dominique, additional, Francken, Michael, additional, Guinet, Jean-Michel, additional, Wahl, Joachim, additional, Ayodo, George, additional, Babiker, Hamza A., additional, Bailliet, Graciela, additional, Balanovska, Elena, additional, Balanovsky, Oleg, additional, Barrantes, Ramiro, additional, Bedoya, Gabriel, additional, Ben-Ami, Haim, additional, Bene, Judit, additional, Berrada, Fouad, additional, Bravi, Claudio M., additional, Brisighelli, Francesca, additional, Busby, George B. J., additional, Cali, Francesco, additional, Churnosov, Mikhail, additional, Cole, David E. C., additional, Corach, Daniel, additional, Damba, Larissa, additional, van Driem, George, additional, Dryomov, Stanislav, additional, Dugoujon, Jean-Michel, additional, Fedorova, Sardana A., additional, Gallego Romero, Irene, additional, Gubina, Marina, additional, Hammer, Michael, additional, Henn, Brenna M., additional, Hervig, Tor, additional, Hodoglugil, Ugur, additional, Jha, Aashish R., additional, Karachanak-Yankova, Sena, additional, Khusainova, Rita, additional, Khusnutdinova, Elza, additional, Kittles, Rick, additional, Kivisild, Toomas, additional, Klitz, William, additional, Kučinskas, Vaidutis, additional, Kushniarevich, Alena, additional, Laredj, Leila, additional, Litvinov, Sergey, additional, Loukidis, Theologos, additional, Mahley, Robert W., additional, Melegh, Béla, additional, Metspalu, Ene, additional, Molina, Julio, additional, Mountain, Joanna, additional, Näkkäläjärvi, Klemetti, additional, Nesheva, Desislava, additional, Nyambo, Thomas, additional, Osipova, Ludmila, additional, Parik, Jüri, additional, Platonov, Fedor, additional, Posukh, Olga, additional, Romano, Valentino, additional, Rothhammer, Francisco, additional, Rudan, Igor, additional, Ruizbakiev, Ruslan, additional, Sahakyan, Hovhannes, additional, Sajantila, Antti, additional, Salas, Antonio, additional, Starikovskaya, Elena B., additional, Tarekegn, Ayele, additional, Toncheva, Draga, additional, Turdikulova, Shahlo, additional, Uktveryte, Ingrida, additional, Utevska, Olga, additional, Vasquez, René, additional, Villena, Mercedes, additional, Voevoda, Mikhail, additional, Winkler, Cheryl A., additional, Yepiskoposyan, Levon, additional, Zalloua, Pierre, additional, Zemunik, Tatijana, additional, Cooper, Alan, additional, Capelli, Cristian, additional, Thomas, Mark G., additional, Ruiz-Linares, Andres, additional, Tishkoff, Sarah A., additional, Singh, Lalji, additional, Thangaraj, Kumarasamy, additional, Villems, Richard, additional, Comas, David, additional, Sukernik, Rem, additional, Metspalu, Mait, additional, Meyer, Matthias, additional, Eichler, Evan E., additional, Burger, Joachim, additional, Slatkin, Montgomery, additional, Pääbo, Svante, additional, Kelso, Janet, additional, Reich, David, additional, and Krause, Johannes, additional

Published
2014
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32. High resolution of human evolutionary trees with polymorphic microsatellites

Author

Anne M. Bowcock, Andres Ruiz-Linares, Eric Minch, J.R. Kidd, J. Tomfohrde, and Luigi Luca Cavalli-Sforza

Subjects
Genetics, Asia, Polymorphism, Genetic, Multidisciplinary, Phylogenetic tree, Population genetics, Hominidae, DNA, Satellite, Biology, Biological Evolution, Europe, Genetic marker, Africa, Genetic variation, Blood Group Antigens, Animals, Humans, Microsatellite, Genetic variability, Americas, Allele, Allele frequency, Polymorphism, Restriction Fragment Length, Repetitive Sequences, Nucleic Acid
Abstract

Genetic variation at hypervariable loci is being used extensively for linkage analysis and individual identification, and may be useful for inter-population studies. Here we show that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy. This is achieved by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations. Reliable evolutionary relationships could also be established in comparisons among human populations but not among great ape species, probably because of constraints on allele length variation. Among human populations, diversity of microsatellites is highest in Africa, which is in contrast to other nuclear markers and supports the hypothesis of an African origin for humans.

Published
1994

33. Erratum: Corrigendum: Reconstructing Native American population history

Author

Reich, David, primary, Patterson, Nick, additional, Campbell, Desmond, additional, Tandon, Arti, additional, Mazieres, Stéphane, additional, Ray, Nicolas, additional, Parra, Maria V., additional, Rojas, Winston, additional, Duque, Constanza, additional, Mesa, Natalia, additional, García, Luis F., additional, Triana, Omar, additional, Blair, Silvia, additional, Maestre, Amanda, additional, Dib, Juan C., additional, Bravi, Claudio M., additional, Bailliet, Graciela, additional, Corach, Daniel, additional, Hünemeier, Tábita, additional, Bortolini, Maria Cátira, additional, Salzano, Francisco M., additional, Petzl-Erler, María Luiza, additional, Acuña-Alonzo, Victor, additional, Aguilar-Salinas, Carlos, additional, Canizales-Quinteros, Samuel, additional, Tusié-Luna, Teresa, additional, Riba, Laura, additional, Rodríguez-Cruz, Maricela, additional, Lopez-Alarcón, Mardia, additional, Coral-Vazquez, Ramón, additional, Canto-Cetina, Thelma, additional, Silva-Zolezzi, Irma, additional, Fernandez-Lopez, Juan Carlos, additional, Contreras, Alejandra V., additional, Jimenez-Sanchez, Gerardo, additional, Gómez-Vázquez, Maria José, additional, Molina, Julio, additional, Carracedo, Ángel, additional, Salas, Antonio, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, B.Witonsky, David, additional, Alkorta-Aranburu, Gorka, additional, Sukernik, Rem I., additional, Osipova, Ludmila, additional, Fedorova, Sardana A., additional, Vasquez, René, additional, Villena, Mercedes, additional, Moreau, Claudia, additional, Barrantes, Ramiro, additional, Pauls, David, additional, Excoffier, Laurent, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Dugoujon, Jean-Michel, additional, Larrouy, Georges, additional, Klitz, William, additional, Labuda, Damian, additional, Kidd, Judith, additional, Kidd, Kenneth, additional, Di Rienzo, Anna, additional, Freimer, Nelson B., additional, Price, Alkes L., additional, and Ruiz-Linares, Andrés, additional

Published
2012
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34. Erratum: Corrigendum: Reconstructing Native American population history

Author

María Victoria Parra, Claudia Moreau, Julio Molina, David L. Pauls, Daniel Corach, Arti Tandon, Ramón Mauricio Coral-Vázquez, Desmond Campbell, Andres Ruiz-Linares, Thelma Canto-Cetina, David Reich, Francisco Rothhammer, René Vasquez, Mercedes Villena, Nick Patterson, Jean-Michel Dugoujon, Winston Rojas, Giovanni Poletti, Nelson B. Freimer, Carlos A. Aguilar-Salinas, Constanza Duque, Irma Silva-Zolezzi, Gorka Alkorta-Aranburu, Ludmila P. Osipova, Ramiro Barrantes, Mardia López-Alarcón, Gerardo Jimenez-Sanchez, Sardana A. Fedorova, William Klitz, Kenneth K. Kidd, Samuel Canizales-Quinteros, Amanda Maestre, Stéphane Mazières, Gabriel Bedoya, Maricela Rodríguez-Cruz, Francisco M. Salzano, David B. Witonsky, Graciela Bailliet, Natalia Mesa, Rem I. Sukernik, Victor Acuña-Alonzo, Juan Carlos Fernández-López, Judith R. Kidd, Silvia Blair, Laura Riba, Tábita Hünemeier, Anna Di Rienzo, Luis F. García, Nicolas Ray, Antonio Salas, Damian Labuda, Omar Triana, Carla Gallo, Maria Luiza Petzl-Erler, María José Gómez-Vázquez, Georges Larrouy, Claudio M. Bravi, Juan Carlos Dib, Maria Cátira Bortolini, Alkes L. Price, Alejandra V. Contreras, Teresa Tusié-Luna, Angel Carracedo, and Laurent Excoffier

Subjects
Multidisciplinary, Evolutionary biology, Biological anthropology, Genomics, Biology, Native american population, Genealogy, Allotype
Abstract

Nature 488, 370–374 (2012); doi:10.1038/nature11258 At the time of publication of this Letter, the authors were unaware of a manuscript arriving at broadly similar conclusions based on allotype analysis by Williams et al.1, which appeared in the American Journal of Physical Anthropology.

Published
2012

35. Reconstructing Native American population history

Author

Reich, David, primary, Patterson, Nick, additional, Campbell, Desmond, additional, Tandon, Arti, additional, Mazieres, Stéphane, additional, Ray, Nicolas, additional, Parra, Maria V., additional, Rojas, Winston, additional, Duque, Constanza, additional, Mesa, Natalia, additional, García, Luis F., additional, Triana, Omar, additional, Blair, Silvia, additional, Maestre, Amanda, additional, Dib, Juan C., additional, Bravi, Claudio M., additional, Bailliet, Graciela, additional, Corach, Daniel, additional, Hünemeier, Tábita, additional, Bortolini, Maria Cátira, additional, Salzano, Francisco M., additional, Petzl-Erler, María Luiza, additional, Acuña-Alonzo, Victor, additional, Aguilar-Salinas, Carlos, additional, Canizales-Quinteros, Samuel, additional, Tusié-Luna, Teresa, additional, Riba, Laura, additional, Rodríguez-Cruz, Maricela, additional, Lopez-Alarcón, Mardia, additional, Coral-Vazquez, Ramón, additional, Canto-Cetina, Thelma, additional, Silva-Zolezzi, Irma, additional, Fernandez-Lopez, Juan Carlos, additional, Contreras, Alejandra V., additional, Jimenez-Sanchez, Gerardo, additional, Gómez-Vázquez, Maria José, additional, Molina, Julio, additional, Carracedo, Ángel, additional, Salas, Antonio, additional, Gallo, Carla, additional, Poletti, Giovanni, additional, Witonsky, David B., additional, Alkorta-Aranburu, Gorka, additional, Sukernik, Rem I., additional, Osipova, Ludmila, additional, Fedorova, Sardana A., additional, Vasquez, René, additional, Villena, Mercedes, additional, Moreau, Claudia, additional, Barrantes, Ramiro, additional, Pauls, David, additional, Excoffier, Laurent, additional, Bedoya, Gabriel, additional, Rothhammer, Francisco, additional, Dugoujon, Jean-Michel, additional, Larrouy, Georges, additional, Klitz, William, additional, Labuda, Damian, additional, Kidd, Judith, additional, Kidd, Kenneth, additional, Di Rienzo, Anna, additional, Freimer, Nelson B., additional, Price, Alkes L., additional, and Ruiz-Linares, Andrés, additional

Published
2012
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37. Chromosome region 2p25 is linked and associated with type 1 diabetes in Colombia

Author

Pineda-Trujilo, Nicolas, primary, Uribe, Federico, additional, Montoya, Fabiola, additional, Alfaro, Juan-Manuel, additional, Latorre, Guillermo, additional, Villegas, Alberto, additional, Ceron, Javier, additional, Perez, Andres-Felipe, additional, Ospina, Mariano, additional, Naranjo, Andres, additional, Serrano, Abel, additional, Duque, Ivan, additional, Castrillon, Debora, additional, Abad, Alberto, additional, Bedoya, Gabriel, additional, Balthazar, Vital, additional, and Ruiz-Linares, Andres, additional

Published
2010
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38. Strong association of socioeconomic status with genetic ancestry in Latinos: implications for admixture studies of type 2 diabetes

Author

Florez, J. C., primary, Price, A. L., additional, Campbell, D., additional, Riba, L., additional, Parra, M. V., additional, Yu, F., additional, Duque, C., additional, Saxena, R., additional, Gallego, N., additional, Tello-Ruiz, M., additional, Franco, L., additional, Rodríguez-Torres, M., additional, Villegas, A., additional, Bedoya, G., additional, Aguilar-Salinas, C. A., additional, Tusié-Luna, M. T., additional, Ruiz-Linares, A., additional, and Reich, D., additional

Published
2009
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39. African ancestry is associated with risk of asthma and high total serum IgE in a population from the Caribbean Coast of Colombia

Author

Vergara, Candelaria, primary, Caraballo, Luis, additional, Mercado, Dilia, additional, Jimenez, Silvia, additional, Rojas, Winston, additional, Rafaels, Nicholas, additional, Hand, Tracey, additional, Campbell, Monica, additional, Tsai, Yuhjung J., additional, Gao, Li, additional, Duque, Constanza, additional, Lopez, Sergio, additional, Bedoya, Gabriel, additional, Ruiz-Linares, Andrés, additional, and Barnes, Kathleen C., additional

Published
2009
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40. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies

Author

Service, Susan, primary, DeYoung, Joseph, additional, Karayiorgou, Maria, additional, Roos, J Louw, additional, Pretorious, Herman, additional, Bedoya, Gabriel, additional, Ospina, Jorge, additional, Ruiz-Linares, Andres, additional, Macedo, António, additional, Palha, Joana Almeida, additional, Heutink, Peter, additional, Aulchenko, Yurii, additional, Oostra, Ben, additional, van Duijn, Cornelia, additional, Jarvelin, Marjo-Riitta, additional, Varilo, Teppo, additional, Peddle, Lynette, additional, Rahman, Proton, additional, Piras, Giovanna, additional, Monne, Maria, additional, Murray, Sarah, additional, Galver, Luana, additional, Peltonen, Leena, additional, Sabatti, Chiara, additional, Collins, Andrew, additional, and Freimer, Nelson, additional

Published
2006
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