Search

Your search keyword '"Rousseau, Simon"' showing total 9 results
Start Over Author "Rousseau, Simon" Publisher springer science and business media llc
9 results on '"Rousseau, Simon"'

2. Identification of transcriptional regulatory network associated with response of host epithelial cells to SARS-CoV-2

Author

Su, Chen, Rousseau, Simon, and Emad, Amin

Subjects
0303 health sciences, Multidisciplinary, SARS-CoV-2, Sequence Analysis, RNA, Gene Expression Profiling, Systems Biology, Science, COVID-19, Epithelial Cells, Models, Biological, Article, Computational biology and bioinformatics, Gene regulatory networks, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Gene Expression Regulation, A549 Cells, 030220 oncology & carcinogenesis, Humans, Medicine, 030304 developmental biology
Abstract

Identification of transcriptional regulatory mechanisms and signaling networks involved in the response of host cells to infection by SARS-CoV-2 is a powerful approach that provides a systems biology view of gene expression programs involved in COVID-19 and may enable the identification of novel therapeutic targets and strategies to mitigate the impact of this disease. In this study, our goal was to identify a transcriptional regulatory network that is associated with gene expression changes between samples infected by SARS-CoV-2 and those that are infected by other respiratory viruses to narrow the results on those enriched or specific to SARS-CoV-2. We combined a series of recently developed computational tools to identify transcriptional regulatory mechanisms involved in the response of epithelial cells to infection by SARS-CoV-2, and particularly regulatory mechanisms that are specific to this virus when compared to other viruses. In addition, using network-guided analyses, we identified kinases associated with this network. The results identified pathways associated with regulation of inflammation (MAPK14) and immunity (BTK, MBX) that may contribute to exacerbate organ damage linked with complications of COVID-19. The regulatory network identified herein reflects a combination of known hits and novel candidate pathways supporting the novel computational pipeline presented herein to quickly narrow down promising avenues of investigation when facing an emerging and novel disease such as COVID-19.

Published
2021

3. Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis

Author

Sangwan, Veena, primary, Al-Marzouki, Luai, additional, Pal, Sanjima, additional, Stavrakos, Vivian, additional, Alzahrani, Malak, additional, Antonatos, Dorothy, additional, Nevo, Yehonatan, additional, Camilleri-Broët, Sophie, additional, Rayes, Roni, additional, Bourdeau, France, additional, Giannias, Betty, additional, Bertos, Nicholas, additional, Bailey, Swneke, additional, Rousseau, Simon, additional, Cools-Lartigue, Jonathan, additional, Spicer, Jonathan D., additional, and Ferri, Lorenzo, additional

Published
2021
Full Text
View/download PDF

5. Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Author

Mackenzie, Jared S., primary, Lamprecht, Dirk A., additional, Asmal, Rukaya, additional, Adamson, John H., additional, Borah, Khushboo, additional, Beste, Dany J. V., additional, Lee, Bei Shi, additional, Pethe, Kevin, additional, Rousseau, Simon, additional, Krieger, Inna, additional, Sacchettini, James C., additional, Glasgow, Joel N., additional, and Steyn, Adrie J. C., additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results