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Your search keyword '"Rose Brannon A"' showing total 3 results
Start Over Author "Rose Brannon A" Publisher springer science and business media llc
3 results on '"Rose Brannon A"'

1. Overall survival with circulating tumor DNA-guided therapy in advanced non-small-cell lung cancer

Author

Jee, Justin, primary, Lebow, Emily S., additional, Yeh, Randy, additional, Das, Jeeban P., additional, Namakydoust, Azadeh, additional, Paik, Paul K., additional, Chaft, Jamie E., additional, Jayakumaran, Gowtham, additional, Rose Brannon, A., additional, Benayed, Ryma, additional, Zehir, Ahmet, additional, Donoghue, Mark, additional, Schultz, Nikolaus, additional, Chakravarty, Debyani, additional, Kundra, Ritika, additional, Madupuri, Ramyasree, additional, Murciano-Goroff, Yonina R., additional, Tu, Hai-Yan, additional, Xu, Chong-Rui, additional, Martinez, Andrés, additional, Wilhelm, Clare, additional, Galle, Jesse, additional, Daly, Bobby, additional, Yu, Helena A., additional, Offin, Michael, additional, Hellmann, Matthew D., additional, Lito, Piro, additional, Arbour, Kathryn C., additional, Zauderer, Marjorie G., additional, Kris, Mark G., additional, Ng, Kenneth K., additional, Eng, Juliana, additional, Preeshagul, Isabel, additional, Victoria Lai, W., additional, Fiore, John J., additional, Iqbal, Afsheen, additional, Molena, Daniela, additional, Rocco, Gaetano, additional, Park, Bernard J., additional, Lim, Lee P., additional, Li, Mark, additional, Tong-Li, Candace, additional, De Silva, Madhawa, additional, Chan, David L., additional, Diakos, Connie I., additional, Itchins, Malinda, additional, Clarke, Stephen, additional, Pavlakis, Nick, additional, Lee, Adrian, additional, Rekhtman, Natasha, additional, Chang, Jason, additional, Travis, William D., additional, Riely, Gregory J., additional, Solit, David B., additional, Gonen, Mithat, additional, Rusch, Valerie W., additional, Rimner, Andreas, additional, Gomez, Daniel, additional, Drilon, Alexander, additional, Scher, Howard I., additional, Shah, Sohrab P., additional, Berger, Michael F., additional, Arcila, Maria E., additional, Ladanyi, Marc, additional, Levine, Ross L., additional, Shen, Ronglai, additional, Razavi, Pedram, additional, Reis-Filho, Jorge S., additional, Jones, David R., additional, Rudin, Charles M., additional, Isbell, James M., additional, and Li, Bob T., additional

Published
2022
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2. Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer

Author

Christopher J. Pinto, Stephanie Reyes, Donna M. Fitzgerald, Dejan Juric, Charlotte S. Walmsley, Xin Gao, Jeffrey A. Engelman, James R. Stone, Martin S. Taylor, Rebecca Leary, A. Rose Brannon, Islam Baiev, L. Henderson, Avinash Das Sahu, Maida Williams Broudo, Christopher T. Chen, Supriya K. Saha, Bernard Pereira, Wendy Winckler, Read Allen, Lipika Goyal, and Catarina D. Campbell

Subjects
Male, 0301 basic medicine, Time Factors, Somatic cell, DNA Mutational Analysis, General Physics and Astronomy, medicine.disease_cause, Metastasis, Circulating Tumor DNA, Cohort Studies, Breast cancer, 0302 clinical medicine, Reference Values, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Cancer genomics, Tumor Microenvironment, RNA-Seq, Mutation, Multidisciplinary, medicine.diagnostic_test, Neoadjuvant Therapy, Cell-free fetal DNA, 030220 oncology & carcinogenesis, Female, Autopsy, DNA Copy Number Variations, Tumour heterogeneity, Science, Sensitivity and Specificity, Tumor heterogeneity, Article, General Biochemistry, Genetics and Molecular Biology, Genetic Heterogeneity, 03 medical and health sciences, Exome Sequencing, Biopsy, Biomarkers, Tumor, medicine, Humans, Point Mutation, Spatial Analysis, Tumor microenvironment, business.industry, Point mutation, Cancer, Chemoradiotherapy, Adjuvant, General Chemistry, medicine.disease, 030104 developmental biology, Cancer research, business
Abstract

In patients with metastatic cancer, spatial heterogeneity of somatic alterations may lead to incomplete assessment of a cancer’s mutational profile when analyzing a single tumor biopsy. In this study, we perform sequencing of cell-free DNA (cfDNA) and distinct metastatic tissue samples from ten rapid autopsy cases with pre-treated metastatic cancer. We show that levels of heterogeneity in genetic biomarkers vary between patients but that gene expression signatures representative of the tumor microenvironment are more consistent. Across nine patients with plasma samples available, we are able to detect 62/62 truncal and 47/121 non-truncal point mutations in cfDNA. We observe that mutation clonality in cfDNA is correlated with the number of metastatic lesions in which the mutation is detected and use this result to derive a clonality threshold to classify truncal and non-truncal driver alterations with reasonable specificity. In contrast, mutation truncality is more often incorrectly assigned when studying single tissue samples. Our results demonstrate the utility of a single cfDNA sample relative to that of single tissue samples when treating patients with metastatic cancer., It is currently unclear if cell-free DNA samples from metastatic cancers are as informative as tissue ones for cancer profiling. Here the authors show that cell-free DNA samples from rapid autopsies capture clonal and subclonal alterations of metastatic tumours and reveal more driver alterations than single tissue samples.

Published
2021
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3. Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS

Author

Rose Brannon, A., primary, Jayakumaran, Gowtham, additional, Diosdado, Monica, additional, Patel, Juber, additional, Razumova, Anna, additional, Hu, Yu, additional, Meng, Fanli, additional, Haque, Mohammad, additional, Sadowska, Justyna, additional, Murphy, Brian J., additional, Baldi, Tessara, additional, Johnson, Ian, additional, Ptashkin, Ryan, additional, Hasan, Maysun, additional, Srinivasan, Preethi, additional, Rema, Anoop Balakrishnan, additional, Rijo, Ivelise, additional, Agarunov, Aaron, additional, Won, Helen, additional, Perera, Dilmi, additional, Brown, David N., additional, Samoila, Aliaksandra, additional, Jing, Xiaohong, additional, Gedvilaite, Erika, additional, Yang, Julie L., additional, Stephens, Dennis P., additional, Dix, Jenna-Marie, additional, DeGroat, Nicole, additional, Nafa, Khedoudja, additional, Syed, Aijazuddin, additional, Li, Alan, additional, Lebow, Emily S., additional, Bowman, Anita S., additional, Ferguson, Donna C., additional, Liu, Ying, additional, Mata, Douglas A., additional, Sharma, Rohit, additional, Yang, Soo-Ryum, additional, Bale, Tejus, additional, Benhamida, Jamal K., additional, Chang, Jason C., additional, Dogan, Snjezana, additional, Hameed, Meera R., additional, Hechtman, Jaclyn F., additional, Moung, Christine, additional, Ross, Dara S., additional, Vakiani, Efsevia, additional, Vanderbilt, Chad M., additional, Yao, JinJuan, additional, Razavi, Pedram, additional, Smyth, Lillian M., additional, Chandarlapaty, Sarat, additional, Iyer, Gopa, additional, Abida, Wassim, additional, Harding, James J., additional, Krantz, Benjamin, additional, O’Reilly, Eileen, additional, Yu, Helena A., additional, Li, Bob T., additional, Rudin, Charles M., additional, Diaz, Luis, additional, Solit, David B., additional, Arcila, Maria E., additional, Ladanyi, Marc, additional, Loomis, Brian, additional, Tsui, Dana, additional, Berger, Michael F., additional, Zehir, Ahmet, additional, and Benayed, Ryma, additional

Published
2021
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