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42 results on '"Roobol, Monique J."'

1. External validation of the Rotterdam Prostate Cancer Risk Calculator within a Dutch high-risk clinical cohort

Author

Hagens, Marinus J., primary, Stelwagen, Piter J., additional, Veerman, Hans, additional, Rynja, Sybren P., additional, Smeenge, Martijn, additional, van der Noort, Vincent, additional, Roeleveld, Ton A., additional, van Kesteren, Jolien, additional, Remmers, Sebastiaan, additional, Roobol, Monique J., additional, van Leeuwen, Pim J., additional, and van der Poel, Henk G., additional

Published
2023
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3. External validation of the Rotterdam prostate cancer risk calculator within a high-risk Dutch clinical cohort

Author

Hagens, Marinus J., primary, Stelwagen, Piter J., additional, Veerman, Hans, additional, Rynja, Sybren P., additional, Smeenge, Martijn, additional, van der Noort, Vincent, additional, Roeleveld, Ton A., additional, van Kesteren, Jolien, additional, Remmers, Sebastiaan, additional, Roobol, Monique J., additional, van Leeuwen, Pim J., additional, and van der Poel, Henk G., additional

Published
2022
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4. Cross-cultural differences in men on active surveillance’ anxiety: a longitudinal comparison between Italian and Dutch patients from the Prostate cancer Research International Active Surveillance study

Author

Dordoni, Paola, primary, Remmers, Sebastiaan, additional, Valdagni, Riccardo, additional, Bellardita, Lara, additional, De Luca, Letizia, additional, Badenchini, Fabio, additional, Marenghi, Cristina, additional, Roobol, Monique J., additional, and Venderbos, Lionne D. F., additional

Published
2022
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5. An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk

Author

Wu, Lang, Yang, Yaohua, Guo, Xingyi, Shu, Xiao Ou, Cai, Qiuyin, Shu, Xiang, Li, Bingshan, Tao, Ran, Wu, Chong, Nikas, Jason B., Sun, Yanfa, Zhu, Jingjing, Roobol, Monique J., Giles, Graham G., Brenner, Hermann, John, Esther M., Clements, Judith, Grindedal, Eli Marie, Park, Jong Y., Stanford, Janet L., Kote-Jarai, Zsofia, Haiman, Christopher A., Eeles, Rosalind A., Zheng, Wei, Long, Jirong, Henderson, Brian E., Schumacher, Fredrick R., Easton, Douglas, Benlloch, Sara, Olama, Ali Amin Al, Muir, Kenneth, Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Gapstur, Susan M., Stevens, Victoria L., Tangen, Catherine M., Batra, Jyotsna, Gronberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Nordestgaard, Børge G., Li, Bingshan [0000-0003-2129-168X], Wu, Chong [0000-0002-8400-1785], Nikas, Jason B [0000-0001-9703-0422], Roobol, Monique J [0000-0001-6967-1708], Giles, Graham G [0000-0003-4946-9099], Park, Jong Y [0000-0002-6384-6447], Eeles, Rosalind A [0000-0002-3698-6241], Zheng, Wei [0000-0003-1226-070X], Apollo - University of Cambridge Repository, Hunter, DJ, consortium, PRACTICAL, Consortium, CRUK, Consortium, BPC3, Consortium, CAPS, Consortium, PEGASUS, and Urology

Subjects
0301 basic medicine, Male, General Physics and Astronomy, 02 engineering and technology, VARIANTS, urologic and male genital diseases, DISEASE, CRUK Consortium, Prostate cancer, BPC3 Consortium, Risk Factors, Epidemiology of cancer, GWAS, lcsh:Science, Cancer genetics, GENE-EXPRESSION, Genetics, Multidisciplinary, Methylation, 021001 nanoscience & nanotechnology, STATISTICS, Multidisciplinary Sciences, CpG site, DNA methylation, Science & Technology - Other Topics, 0210 nano-technology, SUSCEPTIBILITY LOCI, Science, Biology, Article, General Biochemistry, Genetics and Molecular Biology, PRACTICAL consortium, 03 medical and health sciences, Cancer epidemiology, SDG 3 - Good Health and Well-being, REVEALS, Genetic model, medicine, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Gene, Genetic Association Studies, Genetic association, Science & Technology, Models, Genetic, MORTALITY, Prostatic Neoplasms, General Chemistry, DNA Methylation, medicine.disease, CAPS Consortium, 030104 developmental biology, TISSUE, ANTIGEN LEVEL, Case-Control Studies, lcsh:Q, CpG Islands, PEGASUS Consortium
Abstract

It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence expression of PrCa target genes. To search for CpG sites associated with PrCa risk, here we establish genetic models to predict methylation (N = 1,595) and conduct association analyses with PrCa risk (79,194 cases and 61,112 controls). We identify 759 CpG sites showing an association, including 15 located at novel loci. Among those 759 CpG sites, methylation of 42 is associated with expression of 28 adjacent genes. Among 22 genes, 18 show an association with PrCa risk. Overall, 25 CpG sites show consistent association directions for the methylation-gene expression-PrCa pathway. We identify DNA methylation biomarkers associated with PrCa, and our findings suggest that specific CpG sites may influence PrCa via regulating expression of candidate PrCa target genes., Genome wide association studies have identified multiple loci associated with risk of developing prostate cancer but the functional significance of many of these are unknown. Here, after generating models to predict methylation, the authors identify CpG methylation sites associated with prostate cancer.

Published
2021
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6. Decision aid and cost compensation influence uptake of PSA-based early detection without affecting decisional conflict: a cluster randomised trial

Author

Tiedje, Dorothee, primary, Borowski, Matthias, additional, Simbrich, Alexandra, additional, Schlößler, Kathrin, additional, Kruse, Klaus, additional, Bothe, Christiane, additional, Kuss, Katrin, additional, Adarkwah, Charles Christian, additional, Maisel, Peter, additional, Jendyk, Ralf, additional, Kurosinski, Marc-André, additional, Gerß, Joachim, additional, Tschuschke, Christian, additional, Becker, Ralf, additional, Roobol, Monique J., additional, Bangma, Chris H., additional, Hense, Hans-Werner, additional, Donner-Banzhoff, Norbert, additional, and Semjonow, Axel, additional

Published
2021
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7. Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Author

Conti, David V., primary, Darst, Burcu F., additional, Moss, Lilit C., additional, Saunders, Edward J., additional, Sheng, Xin, additional, Chou, Alisha, additional, Schumacher, Fredrick R., additional, Olama, Ali Amin Al, additional, Benlloch, Sara, additional, Dadaev, Tokhir, additional, Brook, Mark N., additional, Sahimi, Ali, additional, Hoffmann, Thomas J., additional, Takahashi, Atushi, additional, Matsuda, Koichi, additional, Momozawa, Yukihide, additional, Fujita, Masashi, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Wan, Peggy, additional, Le Marchand, Loic, additional, Wilkens, Lynne R., additional, Stevens, Victoria L., additional, Gapstur, Susan M., additional, Carter, Brian D., additional, Schleutker, Johanna, additional, Tammela, Teuvo L. J., additional, Sipeky, Csilla, additional, Auvinen, Anssi, additional, Giles, Graham G., additional, Southey, Melissa C., additional, MacInnis, Robert J., additional, Cybulski, Cezary, additional, Wokołorczyk, Dominika, additional, Lubiński, Jan, additional, Neal, David E., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Martin, Richard M., additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Weischer, Maren, additional, Bojesen, Stig E., additional, Røder, Martin Andreas, additional, Iversen, Peter, additional, Batra, Jyotsna, additional, Chambers, Suzanne, additional, Moya, Leire, additional, Horvath, Lisa, additional, Clements, Judith A., additional, Tilley, Wayne, additional, Risbridger, Gail P., additional, Gronberg, Henrik, additional, Aly, Markus, additional, Szulkin, Robert, additional, Eklund, Martin, additional, Nordström, Tobias, additional, Pashayan, Nora, additional, Dunning, Alison M., additional, Ghoussaini, Maya, additional, Travis, Ruth C., additional, Key, Tim J., additional, Riboli, Elio, additional, Park, Jong Y., additional, Sellers, Thomas A., additional, Lin, Hui-Yi, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Mucci, Lorelei A., additional, Giovannucci, Edward, additional, Lindstrom, Sara, additional, Kraft, Peter, additional, Hunter, David J., additional, Penney, Kathryn L., additional, Turman, Constance, additional, Tangen, Catherine M., additional, Goodman, Phyllis J., additional, Thompson, Ian M., additional, Hamilton, Robert J., additional, Fleshner, Neil E., additional, Finelli, Antonio, additional, Parent, Marie-Élise, additional, Stanford, Janet L., additional, Ostrander, Elaine A., additional, Geybels, Milan S., additional, Koutros, Stella, additional, Freeman, Laura E. Beane, additional, Stampfer, Meir, additional, Wolk, Alicja, additional, Håkansson, Niclas, additional, Andriole, Gerald L., additional, Hoover, Robert N., additional, Machiela, Mitchell J., additional, Sørensen, Karina Dalsgaard, additional, Borre, Michael, additional, Blot, William J., additional, Zheng, Wei, additional, Yeboah, Edward D., additional, Mensah, James E., additional, Lu, Yong-Jie, additional, Zhang, Hong-Wei, additional, Feng, Ninghan, additional, Mao, Xueying, additional, Wu, Yudong, additional, Zhao, Shan-Chao, additional, Sun, Zan, additional, Thibodeau, Stephen N., additional, McDonnell, Shannon K., additional, Schaid, Daniel J., additional, West, Catharine M. L., additional, Burnet, Neil, additional, Barnett, Gill, additional, Maier, Christiane, additional, Schnoeller, Thomas, additional, Luedeke, Manuel, additional, Kibel, Adam S., additional, Drake, Bettina F., additional, Cussenot, Olivier, additional, Cancel-Tassin, Géraldine, additional, Menegaux, Florence, additional, Truong, Thérèse, additional, Koudou, Yves Akoli, additional, John, Esther M., additional, Grindedal, Eli Marie, additional, Maehle, Lovise, additional, Khaw, Kay-Tee, additional, Ingles, Sue A., additional, Stern, Mariana C., additional, Vega, Ana, additional, Gómez-Caamaño, Antonio, additional, Fachal, Laura, additional, Rosenstein, Barry S., additional, Kerns, Sarah L., additional, Ostrer, Harry, additional, Teixeira, Manuel R., additional, Paulo, Paula, additional, Brandão, Andreia, additional, Watya, Stephen, additional, Lubwama, Alexander, additional, Bensen, Jeannette T., additional, Fontham, Elizabeth T. H., additional, Mohler, James, additional, Taylor, Jack A., additional, Kogevinas, Manolis, additional, Llorca, Javier, additional, Castaño-Vinyals, Gemma, additional, Cannon-Albright, Lisa, additional, Teerlink, Craig C., additional, Huff, Chad D., additional, Strom, Sara S., additional, Multigner, Luc, additional, Blanchet, Pascal, additional, Brureau, Laurent, additional, Kaneva, Radka, additional, Slavov, Chavdar, additional, Mitev, Vanio, additional, Leach, Robin J., additional, Weaver, Brandi, additional, Brenner, Hermann, additional, Cuk, Katarina, additional, Holleczek, Bernd, additional, Saum, Kai-Uwe, additional, Klein, Eric A., additional, Hsing, Ann W., additional, Kittles, Rick A., additional, Murphy, Adam B., additional, Logothetis, Christopher J., additional, Kim, Jeri, additional, Neuhausen, Susan L., additional, Steele, Linda, additional, Ding, Yuan Chun, additional, Isaacs, William B., additional, Nemesure, Barbara, additional, Hennis, Anselm J. M., additional, Carpten, John, additional, Pandha, Hardev, additional, Michael, Agnieszka, additional, De Ruyck, Kim, additional, De Meerleer, Gert, additional, Ost, Piet, additional, Xu, Jianfeng, additional, Razack, Azad, additional, Lim, Jasmine, additional, Teo, Soo-Hwang, additional, Newcomb, Lisa F., additional, Lin, Daniel W., additional, Fowke, Jay H., additional, Neslund-Dudas, Christine, additional, Rybicki, Benjamin A., additional, Gamulin, Marija, additional, Lessel, Davor, additional, Kulis, Tomislav, additional, Usmani, Nawaid, additional, Singhal, Sandeep, additional, Parliament, Matthew, additional, Claessens, Frank, additional, Joniau, Steven, additional, Van den Broeck, Thomas, additional, Gago-Dominguez, Manuela, additional, Castelao, Jose Esteban, additional, Martinez, Maria Elena, additional, Larkin, Samantha, additional, Townsend, Paul A., additional, Aukim-Hastie, Claire, additional, Bush, William S., additional, Aldrich, Melinda C., additional, Crawford, Dana C., additional, Srivastava, Shiv, additional, Cullen, Jennifer C., additional, Petrovics, Gyorgy, additional, Casey, Graham, additional, Roobol, Monique J., additional, Jenster, Guido, additional, van Schaik, Ron H. N., additional, Hu, Jennifer J., additional, Sanderson, Maureen, additional, Varma, Rohit, additional, McKean-Cowdin, Roberta, additional, Torres, Mina, additional, Mancuso, Nicholas, additional, Berndt, Sonja I., additional, Van Den Eeden, Stephen K., additional, Easton, Douglas F., additional, Chanock, Stephen J., additional, Cook, Michael B., additional, Wiklund, Fredrik, additional, Nakagawa, Hidewaki, additional, Witte, John S., additional, Eeles, Rosalind A., additional, Kote-Jarai, Zsofia, additional, and Haiman, Christopher A., additional

Published
2021
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9. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Author

Conti, David V., primary, Darst, Burcu F., additional, Moss, Lilit C., additional, Saunders, Edward J., additional, Sheng, Xin, additional, Chou, Alisha, additional, Schumacher, Fredrick R., additional, Olama, Ali Amin Al, additional, Benlloch, Sara, additional, Dadaev, Tokhir, additional, Brook, Mark N., additional, Sahimi, Ali, additional, Hoffmann, Thomas J., additional, Takahashi, Atushi, additional, Matsuda, Koichi, additional, Momozawa, Yukihide, additional, Fujita, Masashi, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Wan, Peggy, additional, Le Marchand, Loic, additional, Wilkens, Lynne R., additional, Stevens, Victoria L., additional, Gapstur, Susan M., additional, Carter, Brian D., additional, Schleutker, Johanna, additional, Tammela, Teuvo L. J., additional, Sipeky, Csilla, additional, Auvinen, Anssi, additional, Giles, Graham G., additional, Southey, Melissa C., additional, MacInnis, Robert J., additional, Cybulski, Cezary, additional, Wokołorczyk, Dominika, additional, Lubiński, Jan, additional, Neal, David E., additional, Donovan, Jenny L., additional, Hamdy, Freddie C., additional, Martin, Richard M., additional, Nordestgaard, Børge G., additional, Nielsen, Sune F., additional, Weischer, Maren, additional, Bojesen, Stig E., additional, Røder, Martin Andreas, additional, Iversen, Peter, additional, Batra, Jyotsna, additional, Chambers, Suzanne, additional, Moya, Leire, additional, Horvath, Lisa, additional, Clements, Judith A., additional, Tilley, Wayne, additional, Risbridger, Gail P., additional, Gronberg, Henrik, additional, Aly, Markus, additional, Szulkin, Robert, additional, Eklund, Martin, additional, Nordström, Tobias, additional, Pashayan, Nora, additional, Dunning, Alison M., additional, Ghoussaini, Maya, additional, Travis, Ruth C., additional, Key, Tim J., additional, Riboli, Elio, additional, Park, Jong Y., additional, Sellers, Thomas A., additional, Lin, Hui-Yi, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J., additional, Mucci, Lorelei A., additional, Giovannucci, Edward, additional, Lindstrom, Sara, additional, Kraft, Peter, additional, Hunter, David J., additional, Penney, Kathryn L., additional, Turman, Constance, additional, Tangen, Catherine M., additional, Goodman, Phyllis J., additional, Thompson, Ian M., additional, Hamilton, Robert J., additional, Fleshner, Neil E., additional, Finelli, Antonio, additional, Parent, Marie-Élise, additional, Stanford, Janet L., additional, Ostrander, Elaine A., additional, Geybels, Milan S., additional, Koutros, Stella, additional, Freeman, Laura E. Beane, additional, Stampfer, Meir, additional, Wolk, Alicja, additional, Håkansson, Niclas, additional, Andriole, Gerald L., additional, Hoover, Robert N., additional, Machiela, Mitchell J., additional, Sørensen, Karina Dalsgaard, additional, Borre, Michael, additional, Blot, William J., additional, Zheng, Wei, additional, Yeboah, Edward D., additional, Mensah, James E., additional, Lu, Yong-Jie, additional, Zhang, Hong-Wei, additional, Feng, Ninghan, additional, Mao, Xueying, additional, Wu, Yudong, additional, Zhao, Shan-Chao, additional, Sun, Zan, additional, Thibodeau, Stephen N., additional, McDonnell, Shannon K., additional, Schaid, Daniel J., additional, West, Catharine M. L., additional, Burnet, Neil, additional, Barnett, Gill, additional, Maier, Christiane, additional, Schnoeller, Thomas, additional, Luedeke, Manuel, additional, Kibel, Adam S., additional, Drake, Bettina F., additional, Cussenot, Olivier, additional, Cancel-Tassin, Géraldine, additional, Menegaux, Florence, additional, Truong, Thérèse, additional, Koudou, Yves Akoli, additional, John, Esther M., additional, Grindedal, Eli Marie, additional, Maehle, Lovise, additional, Khaw, Kay-Tee, additional, Ingles, Sue A., additional, Stern, Mariana C., additional, Vega, Ana, additional, Gómez-Caamaño, Antonio, additional, Fachal, Laura, additional, Rosenstein, Barry S., additional, Kerns, Sarah L., additional, Ostrer, Harry, additional, Teixeira, Manuel R., additional, Paulo, Paula, additional, Brandão, Andreia, additional, Watya, Stephen, additional, Lubwama, Alexander, additional, Bensen, Jeannette T., additional, Fontham, Elizabeth T. H., additional, Mohler, James, additional, Taylor, Jack A., additional, Kogevinas, Manolis, additional, Llorca, Javier, additional, Castaño-Vinyals, Gemma, additional, Cannon-Albright, Lisa, additional, Teerlink, Craig C., additional, Huff, Chad D., additional, Strom, Sara S., additional, Multigner, Luc, additional, Blanchet, Pascal, additional, Brureau, Laurent, additional, Kaneva, Radka, additional, Slavov, Chavdar, additional, Mitev, Vanio, additional, Leach, Robin J., additional, Weaver, Brandi, additional, Brenner, Hermann, additional, Cuk, Katarina, additional, Holleczek, Bernd, additional, Saum, Kai-Uwe, additional, Klein, Eric A., additional, Hsing, Ann W., additional, Kittles, Rick A., additional, Murphy, Adam B., additional, Logothetis, Christopher J., additional, Kim, Jeri, additional, Neuhausen, Susan L., additional, Steele, Linda, additional, Ding, Yuan Chun, additional, Isaacs, William B., additional, Nemesure, Barbara, additional, Hennis, Anselm J. M., additional, Carpten, John, additional, Pandha, Hardev, additional, Michael, Agnieszka, additional, De Ruyck, Kim, additional, De Meerleer, Gert, additional, Ost, Piet, additional, Xu, Jianfeng, additional, Razack, Azad, additional, Lim, Jasmine, additional, Teo, Soo-Hwang, additional, Newcomb, Lisa F., additional, Lin, Daniel W., additional, Fowke, Jay H., additional, Neslund-Dudas, Christine, additional, Rybicki, Benjamin A., additional, Gamulin, Marija, additional, Lessel, Davor, additional, Kulis, Tomislav, additional, Usmani, Nawaid, additional, Singhal, Sandeep, additional, Parliament, Matthew, additional, Claessens, Frank, additional, Joniau, Steven, additional, Van den Broeck, Thomas, additional, Gago-Dominguez, Manuela, additional, Castelao, Jose Esteban, additional, Martinez, Maria Elena, additional, Larkin, Samantha, additional, Townsend, Paul A., additional, Aukim-Hastie, Claire, additional, Bush, William S., additional, Aldrich, Melinda C., additional, Crawford, Dana C., additional, Srivastava, Shiv, additional, Cullen, Jennifer C., additional, Petrovics, Gyorgy, additional, Casey, Graham, additional, Roobol, Monique J., additional, Jenster, Guido, additional, van Schaik, Ron H. N., additional, Hu, Jennifer J., additional, Sanderson, Maureen, additional, Varma, Rohit, additional, McKean-Cowdin, Roberta, additional, Torres, Mina, additional, Mancuso, Nicholas, additional, Berndt, Sonja I., additional, Van Den Eeden, Stephen K., additional, Easton, Douglas F., additional, Chanock, Stephen J., additional, Cook, Michael B., additional, Wiklund, Fredrik, additional, Nakagawa, Hidewaki, additional, Witte, John S., additional, Eeles, Rosalind A., additional, Kote-Jarai, Zsofia, additional, and Haiman, Christopher A., additional

Published
2021
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10. Health-related quality of life in Japanese low-risk prostate cancer patients choosing active surveillance: 3-year follow-up from PRIAS-JAPAN

Author

Hirama, Hiromi, primary, Sugimoto, Mikio, additional, Miyatake, Nobuyuki, additional, Kato, Takuma, additional, Venderbos, Lionne D. F., additional, Remmers, Sebastiaan, additional, Shiga, Kenichiro, additional, Yokomizo, Akira, additional, Mitsuzuka, Koji, additional, Matsumoto, Ryuji, additional, Osawa, Takahiro, additional, Abe, Takashige, additional, Sasaki, Hiroshi, additional, Egawa, Shin, additional, Ninomiya, Iku, additional, Hashine, Katsuyoshi, additional, Roobol, Monique J., additional, and Kakehi, Yoshiyuki, additional

Published
2020
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14. Author Correction: Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Author

Sud, Amit, Thomsen, Hauke, Law, Philip J., Försti, Asta, da Silva Filho, Miguel Inacio, Holroyd, Amy, Broderick, Peter, Orlando, Giulia, Lenive, Oleg, Wright, Lauren, Cooke, Rosie, Easton, Douglas, Pharoah, Paul, Dunning, Alison, Peto, Julian, Canzian, Federico, Eeles, Rosalind, Kote-Jarai, Zsofia, Muir, Kenneth, Pashayan, Nora, Henderson, Brian E., Haiman, Christopher A., Benlloch, Sara, Schumacher, Fredrick R., Olama, Ali Amin Al, Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Stevens, Victoria L., Tangen, Catherine M., Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Cancel-Tassin, Géraldine, Koutros, Stella, Sorensen, Karina Dalsgaard, Maehle, Lovise, Neal, David E., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry, Lu, Yong-Jie, Giles, Graham G., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanford, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Brenner, Hermann, Maier, Christiane, Kim, Jeri, John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Gago-Dominguez, Manuela, Roobol, Monique J., Menegaux, Florence, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, von Strandmann, Elke Pogge, Lightfoot, Tracy, Kane, Eleanor, Roman, Eve, Lake, Annette, Montgomery, Dorothy, Jarrett, Ruth F., Swerdlow, Anthony J., Engert, Andreas, Orr, Nick, Hemminki, Kari, and Houlston, Richard S.

Subjects
Science, Medizin, MEDLINE, General Physics and Astronomy, Genome-wide association study, Computational biology, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, Disease susceptibility, immune system diseases, hemic and lymphatic diseases, Classical Hodgkin lymphoma, Humans, Genetic Predisposition to Disease, Author Correction, lcsh:Science, Alleles, HLA-DP beta-Chains, Multidisciplinary, Published Erratum, General Chemistry, Hodgkin Disease, Spelling, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Key (cryptography), lcsh:Q, Psychology, Genome-Wide Association Study, HLA-DRB1 Chains
Abstract

Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10−8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10−17), 6q23.3 (rs6928977, P = 4.62 × 10−11), 10p14 (rs3781093, P = 9.49 × 10−13), 13q34 (rs112998813, P = 4.58 × 10−8) and 16p13.13 (rs34972832, P = 2.12 × 10−8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response., Classical Hodgkin lymphoma is a cancer that originates in lymph nodes. Little is known about its genetic susceptibility. Here, the authors combined existing and new genome-wide association studies to identify risk loci for classical Hodgkin lymphoma at 6q22.33, and nodular sclerosis Hodgkin lymphoma at 3q28, 6q23.3, 10p14, 13q34, 16p13.13.

Published
2019

15. Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, primary, Finucane, Hilary K., additional, Schumacher, Fredrick R., additional, Schmit, Stephanie L., additional, Tyrer, Jonathan P., additional, Han, Younghun, additional, Michailidou, Kyriaki, additional, Lesseur, Corina, additional, Kuchenbaecker, Karoline B., additional, Dennis, Joe, additional, Conti, David V., additional, Casey, Graham, additional, Gaudet, Mia M., additional, Huyghe, Jeroen R., additional, Albanes, Demetrius, additional, Aldrich, Melinda C., additional, Andrew, Angeline S., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antoniou, Antonis C., additional, Antonenkova, Natalia N., additional, Arnold, Susanne M., additional, Aronson, Kristan J., additional, Arun, Banu K., additional, Bandera, Elisa V., additional, Barkardottir, Rosa B., additional, Barnes, Daniel R., additional, Batra, Jyotsna, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Benlloch, Sara, additional, Berchuck, Andrew, additional, Berndt, Sonja I., additional, Bickeböller, Heike, additional, Bien, Stephanie A., additional, Blomqvist, Carl, additional, Boccia, Stefania, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brenton, James D., additional, Brook, Mark N., additional, Brunet, Joan, additional, Brunnström, Hans, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Cadoni, Gabriella, additional, Caldés, Trinidad, additional, Caligo, Maria A., additional, Campbell, Ian, additional, Campbell, Peter T., additional, Cancel-Tassin, Géraldine, additional, Cannon-Albright, Lisa, additional, Campa, Daniele, additional, Caporaso, Neil, additional, Carvalho, André L., additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Christiani, David C., additional, Claes, Kathleen B. M., additional, Claessens, Frank, additional, Clements, Judith, additional, Collée, J. Margriet, additional, Correa, Marcia Cruz, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Daly, Mary B., additional, deFazio, Anna, additional, Devilee, Peter, additional, Diez, Orland, additional, Gago-Dominguez, Manuela, additional, Donovan, Jenny L., additional, Dörk, Thilo, additional, Duell, Eric J., additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Edlund, Christopher K., additional, Edwards, Digna R. Velez, additional, Ellberg, Carolina, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Ferris, Robert L., additional, Liloglou, Triantafillos, additional, Figueiredo, Jane C., additional, Fletcher, Olivia, additional, Fortner, Renée T., additional, Fostira, Florentia, additional, Franceschi, Silvia, additional, Friedman, Eitan, additional, Gallinger, Steven J., additional, Ganz, Patricia A., additional, Garber, Judy, additional, García-Sáenz, José A., additional, Gayther, Simon A., additional, Giles, Graham G., additional, Godwin, Andrew K., additional, Goldberg, Mark S., additional, Goldgar, David E., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Goodman, Gary, additional, Grankvist, Kjell, additional, Greene, Mark H., additional, Gronberg, Henrik, additional, Gronwald, Jacek, additional, Guénel, Pascal, additional, Håkansson, Niclas, additional, Hall, Per, additional, Hamann, Ute, additional, Hamdy, Freddie C., additional, Hamilton, Robert J., additional, Hampe, Jochen, additional, Haugen, Aage, additional, Heitz, Florian, additional, Herrero, Rolando, additional, Hillemanns, Peter, additional, Hoffmeister, Michael, additional, Høgdall, Estrid, additional, Hong, Yun-Chul, additional, Hopper, John L., additional, Houlston, Richard, additional, Hulick, Peter J., additional, Hunter, David J., additional, Huntsman, David G., additional, Idos, Gregory, additional, Imyanitov, Evgeny N., additional, Ingles, Sue Ann, additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, James, Paul, additional, Jenkins, Mark A., additional, Johansson, Mattias, additional, Johansson, Mikael, additional, John, Esther M., additional, Joshi, Amit D., additional, Kaneva, Radka, additional, Karlan, Beth Y., additional, Kelemen, Linda E., additional, Kühl, Tabea, additional, Khaw, Kay-Tee, additional, Khusnutdinova, Elza, additional, Kibel, Adam S., additional, Kiemeney, Lambertus A., additional, Kim, Jeri, additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Kogevinas, Manolis, additional, Kote-Jarai, Zsofia, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Kupryjanczyk, Jolanta, additional, Lacko, Martin, additional, Lam, Stephan, additional, Lambrechts, Diether, additional, Landi, Maria Teresa, additional, Lazarus, Philip, additional, Le, Nhu D., additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lenz, Heinz-Josef, additional, Leslie, Goska, additional, Lessel, Davor, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Li, additional, Li, Christopher I., additional, Lindblom, Annika, additional, Lindor, Noralane M., additional, Liu, Geoffrey, additional, Loupakis, Fotios, additional, Lubiński, Jan, additional, Maehle, Lovise, additional, Maier, Christiane, additional, Mannermaa, Arto, additional, Marchand, Loic Le, additional, Margolin, Sara, additional, May, Taymaa, additional, McGuffog, Lesley, additional, Meindl, Alfons, additional, Middha, Pooja, additional, Miller, Austin, additional, Milne, Roger L., additional, MacInnis, Robert J., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moreno, Victor, additional, Moysich, Kirsten B., additional, Mucci, Lorelei, additional, Muir, Kenneth, additional, Mulligan, Anna Marie, additional, Nathanson, Katherine L., additional, Neal, David E., additional, Ness, Andrew R., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Newcomb, Polly A., additional, Newcomb, Lisa F., additional, Nielsen, Finn Cilius, additional, Nikitina-Zake, Liene, additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Offit, Kenneth, additional, Olah, Edith, additional, Olama, Ali Amin Al, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Olsson, Håkan, additional, Osorio, Ana, additional, Pandha, Hardev, additional, Park, Jong Y., additional, Pashayan, Nora, additional, Parsons, Michael T., additional, Pejovic, Tanja, additional, Penney, Kathryn L., additional, Peters, Wilbert H. M., additional, Phelan, Catherine M., additional, Phipps, Amanda I., additional, Plaseska-Karanfilska, Dijana, additional, Pring, Miranda, additional, Prokofyeva, Darya, additional, Radice, Paolo, additional, Stefansson, Kari, additional, Ramus, Susan J., additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, van Rensburg, Elizabeth J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Risch, Angela, additional, Roobol, Monique J., additional, Rosenstein, Barry S., additional, Rossing, Mary Anne, additional, De Ruyck, Kim, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schabath, Matthew B., additional, Schleutker, Johanna, additional, Schmidt, Marjanka K., additional, Setiawan, V. Wendy, additional, Shen, Hongbing, additional, Siegel, Erin M., additional, Sieh, Weiva, additional, Singer, Christian F., additional, Slattery, Martha L., additional, Sorensen, Karina Dalsgaard, additional, Southey, Melissa C., additional, Spurdle, Amanda B., additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stintzing, Sebastian, additional, Stone, Jennifer, additional, Sundfeldt, Karin, additional, Sutphen, Rebecca, additional, Swerdlow, Anthony J., additional, Tajara, Eloiza H., additional, Tangen, Catherine M., additional, Tardon, Adonina, additional, Taylor, Jack A., additional, Teare, M. Dawn, additional, Teixeira, Manuel R., additional, Terry, Mary Beth, additional, Terry, Kathryn L., additional, Thibodeau, Stephen N., additional, Thomassen, Mads, additional, Bjørge, Line, additional, Tischkowitz, Marc, additional, Toland, Amanda E., additional, Torres, Diana, additional, Townsend, Paul A., additional, Travis, Ruth C., additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Ulrich, Cornelia M., additional, Usmani, Nawaid, additional, Vachon, Celine M., additional, Van Nieuwenhuysen, Els, additional, Vega, Ana, additional, Aguado-Barrera, Miguel Elías, additional, Wang, Qin, additional, Webb, Penelope M., additional, Weinberg, Clarice R., additional, Weinstein, Stephanie, additional, Weissler, Mark C., additional, Weitzel, Jeffrey N., additional, West, Catharine M. L., additional, White, Emily, additional, Whittemore, Alice S., additional, Wichmann, H-Erich, additional, Wiklund, Fredrik, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Woll, Penella, additional, Woods, Michael, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yannoukakos, Drakoulis, additional, Zheng, Wei, additional, Zienolddiny, Shanbeh, additional, Ziogas, Argyrios, additional, Zorn, Kristin K., additional, Lane, Jacqueline M., additional, Saxena, Richa, additional, Thomas, Duncan, additional, Hung, Rayjean J., additional, Diergaarde, Brenda, additional, McKay, James, additional, Peters, Ulrike, additional, Hsu, Li, additional, García-Closas, Montserrat, additional, Eeles, Rosalind A., additional, Chenevix-Trench, Georgia, additional, Brennan, Paul J., additional, Haiman, Christopher A., additional, Simard, Jacques, additional, Easton, Douglas F., additional, Gruber, Stephen B., additional, Pharoah, Paul D. P., additional, Price, Alkes L., additional, Pasaniuc, Bogdan, additional, Amos, Christopher I., additional, Kraft, Peter, additional, and Lindström, Sara, additional

Published
2019
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17. Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, primary, Finucane, Hilary K., additional, Schumacher, Fredrick R., additional, Schmit, Stephanie L., additional, Tyrer, Jonathan P., additional, Han, Younghun, additional, Michailidou, Kyriaki, additional, Lesseur, Corina, additional, Kuchenbaecker, Karoline B., additional, Dennis, Joe, additional, Conti, David V., additional, Casey, Graham, additional, Gaudet, Mia M., additional, Huyghe, Jeroen R., additional, Albanes, Demetrius, additional, Aldrich, Melinda C., additional, Andrew, Angeline S., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antoniou, Antonis C., additional, Antonenkova, Natalia N., additional, Arnold, Susanne M., additional, Aronson, Kristan J., additional, Arun, Banu K., additional, Bandera, Elisa V., additional, Barkardottir, Rosa B., additional, Barnes, Daniel R., additional, Batra, Jyotsna, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Benlloch, Sara, additional, Berchuck, Andrew, additional, Berndt, Sonja I., additional, Bickeböller, Heike, additional, Bien, Stephanie A., additional, Blomqvist, Carl, additional, Boccia, Stefania, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brenton, James D., additional, Brook, Mark N., additional, Brunet, Joan, additional, Brunnström, Hans, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Cadoni, Gabriella, additional, Caldés, Trinidad, additional, Caligo, Maria A., additional, Campbell, Ian, additional, Campbell, Peter T., additional, Cancel-Tassin, Géraldine, additional, Cannon-Albright, Lisa, additional, Campa, Daniele, additional, Caporaso, Neil, additional, Carvalho, André L., additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Christiani, David C., additional, Claes, Kathleen B. M., additional, Claessens, Frank, additional, Clements, Judith, additional, Collée, J. Margriet, additional, Correa, Marcia Cruz, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Daly, Mary B., additional, deFazio, Anna, additional, Devilee, Peter, additional, Diez, Orland, additional, Gago-Dominguez, Manuela, additional, Donovan, Jenny L., additional, Dörk, Thilo, additional, Duell, Eric J., additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Edlund, Christopher K., additional, Edwards, Digna R Velez, additional, Ellberg, Carolina, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Ferris, Robert L., additional, Liloglou, Triantafillos, additional, Figueiredo, Jane C., additional, Fletcher, Olivia, additional, Fortner, Renée T., additional, Fostira, Florentia, additional, Franceschi, Silvia, additional, Friedman, Eitan, additional, Gallinger, Steven J., additional, Ganz, Patricia A., additional, Garber, Judy, additional, García-Sáenz, José A., additional, Gayther, Simon A., additional, Giles, Graham G., additional, Godwin, Andrew K., additional, Goldberg, Mark S., additional, Goldgar, David E., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Goodman, Gary, additional, Grankvist, Kjell, additional, Greene, Mark H., additional, Gronberg, Henrik, additional, Gronwald, Jacek, additional, Guénel, Pascal, additional, Håkansson, Niclas, additional, Hall, Per, additional, Hamann, Ute, additional, Hamdy, Freddie C., additional, Hamilton, Robert J., additional, Hampe, Jochen, additional, Haugen, Aage, additional, Heitz, Florian, additional, Herrero, Rolando, additional, Hillemanns, Peter, additional, Hoffmeister, Michael, additional, Høgdall, Estrid, additional, Hong, Yun-Chul, additional, Hopper, John L., additional, Houlston, Richard, additional, Hulick, Peter J., additional, Hunter, David J., additional, Huntsman, David G., additional, Idos, Gregory, additional, Imyanitov, Evgeny N., additional, Ingles, Sue Ann, additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, James, Paul, additional, Jenkins, Mark A., additional, Johansson, Mattias, additional, Johansson, Mikael, additional, John, Esther M., additional, Joshi, Amit D., additional, Kaneva, Radka, additional, Karlan, Beth Y., additional, Kelemen, Linda E., additional, Kühl, Tabea, additional, Khaw, Kay-Tee, additional, Khusnutdinova, Elza, additional, Kibel, Adam S., additional, Kiemeney, Lambertus A., additional, Kim, Jeri, additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Kogevinas, Manolis, additional, Kote-Jarai, Zsofia, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Kupryjanczyk, Jolanta, additional, Lacko, Martin, additional, Lam, Stephan, additional, Lambrechts, Diether, additional, Landi, Maria Teresa, additional, Lazarus, Philip, additional, Le, Nhu D., additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lenz, Heinz-Josef, additional, Leslie, Goska, additional, Lessel, Davor, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Li, additional, Li, Christopher I., additional, Lindblom, Annika, additional, Lindor, Noralane M., additional, Liu, Geoffrey, additional, Loupakis, Fotios, additional, Lubiński, Jan, additional, Maehle, Lovise, additional, Maier, Christiane, additional, Mannermaa, Arto, additional, Marchand, Loic Le, additional, Margolin, Sara, additional, May, Taymaa, additional, McGuffog, Lesley, additional, Meindl, Alfons, additional, Middha, Pooja, additional, Miller, Austin, additional, Milne, Roger L., additional, MacInnis, Robert J., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moreno, Victor, additional, Moysich, Kirsten B., additional, Mucci, Lorelei, additional, Muir, Kenneth, additional, Mulligan, Anna Marie, additional, Nathanson, Katherine L., additional, Neal, David E., additional, Ness, Andrew R., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Newcomb, Polly A., additional, Newcomb, Lisa F., additional, Nielsen, Finn Cilius, additional, Nikitina-Zake, Liene, additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Offit, Kenneth, additional, Olah, Edith, additional, Olama, Ali Amin Al, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Olsson, Håkan, additional, Osorio, Ana, additional, Pandha, Hardev, additional, Park, Jong Y., additional, Pashayan, Nora, additional, Parsons, Michael T., additional, Pejovic, Tanja, additional, Penney, Kathryn L., additional, Peters, Wilbert H M., additional, Phelan, Catherine M., additional, Phipps, Amanda I., additional, Plaseska-Karanfilska, Dijana, additional, Pring, Miranda, additional, Prokofyeva, Darya, additional, Radice, Paolo, additional, Stefansson, Kari, additional, Ramus, Susan J., additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, van Rensburg, Elizabeth J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Risch, Angela, additional, Roobol, Monique J., additional, Rosenstein, Barry S., additional, Rossing, Mary Anne, additional, De Ruyck, Kim, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schabath, Matthew B., additional, Schleutker, Johanna, additional, Schmidt, Marjanka K., additional, Setiawan, V. Wendy, additional, Shen, Hongbing, additional, Siegel, Erin M., additional, Sieh, Weiva, additional, Singer, Christian F., additional, Slattery, Martha L., additional, Sorensen, Karina Dalsgaard, additional, Southey, Melissa C., additional, Spurdle, Amanda B., additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stintzing, Sebastian, additional, Stone, Jennifer, additional, Sundfeldt, Karin, additional, Sutphen, Rebecca, additional, Swerdlow, Anthony J., additional, Tajara, Eloiza H., additional, Tangen, Catherine M., additional, Tardon, Adonina, additional, Taylor, Jack A., additional, Teare, M. Dawn, additional, Teixeira, Manuel R., additional, Terry, Mary Beth, additional, Terry, Kathryn L., additional, Thibodeau, Stephen N., additional, Thomassen, Mads, additional, Bjørge, Line, additional, Tischkowitz, Marc, additional, Toland, Amanda E., additional, Torres, Diana, additional, Townsend, Paul A., additional, Travis, Ruth C., additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Ulrich, Cornelia M., additional, Usmani, Nawaid, additional, Vachon, Celine M., additional, Van Nieuwenhuysen, Els, additional, Vega, Ana, additional, Aguado-Barrera, Miguel Elías, additional, Wang, Qin, additional, Webb, Penelope M., additional, Weinberg, Clarice R., additional, Weinstein, Stephanie, additional, Weissler, Mark C., additional, Weitzel, Jeffrey N., additional, West, Catharine M. L., additional, White, Emily, additional, Whittemore, Alice S., additional, Wichmann, H-Erich, additional, Wiklund, Fredrik, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Woll, Penella, additional, Woods, Michael, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yannoukakos, Drakoulis, additional, Zheng, Wei, additional, Zienolddiny, Shanbeh, additional, Ziogas, Argyrios, additional, Zorn, Kristin K., additional, Lane, Jacqueline M., additional, Saxena, Richa, additional, Thomas, Duncan, additional, Hung, Rayjean J., additional, Diergaarde, Brenda, additional, McKay, James, additional, Peters, Ulrike, additional, Hsu, Li, additional, García-Closas, Montserrat, additional, Eeles, Rosalind A., additional, Chenevix-Trench, Georgia, additional, Brennan, Paul J., additional, Haiman, Christopher A., additional, Simard, Jacques, additional, Easton, Douglas F., additional, Gruber, Stephen B., additional, Pharoah, Paul D. P., additional, Price, Alkes L., additional, Pasaniuc, Bogdan, additional, Amos, Christopher I., additional, Kraft, Peter, additional, and Lindström, Sara, additional

Published
2019
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24. Rule-based versus probabilistic selection for active surveillance using three definitions of insignificant prostate cancer

Author

Venderbos, Lionne D. F., primary, Roobol, Monique J., additional, Bangma, Chris H., additional, van den Bergh, Roderick C. N., additional, Bokhorst, Leonard P., additional, Nieboer, Daan, additional, Godtman, Rebecka, additional, Hugosson, Jonas, additional, van der Kwast, Theodorus, additional, and Steyerberg, Ewout W., additional

Published
2015
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32. Evaluating the Prostate Cancer Prevention Trial High Grade prostate cancer risk calculator in 10 international biopsy cohorts: results from the prostate biopsy collaborative group

Author

Ankerst, Donna P., primary, Boeck, Andreas, additional, Freedland, Stephen J., additional, Stephen Jones, J., additional, Cronin, Angel M., additional, Roobol, Monique J., additional, Hugosson, Jonas, additional, Kattan, Michael W., additional, Klein, Eric A., additional, Hamdy, Freddie, additional, Neal, David, additional, Donovan, Jenny, additional, Parekh, Dipen J., additional, Klocker, Helmut, additional, Horninger, Wolfgang, additional, Benchikh, Amine, additional, Salama, Gilles, additional, Villers, Arnauld, additional, Moreira, Daniel M., additional, Schröder, Fritz H., additional, Lilja, Hans, additional, Vickers, Andrew J., additional, and Thompson, Ian M., additional

Published
2012
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33. Evaluating the PCPT risk calculator in ten international biopsy cohorts: results from the Prostate Biopsy Collaborative Group

Author

Ankerst, Donna P., primary, Boeck, Andreas, additional, Freedland, Stephen J., additional, Thompson, Ian M., additional, Cronin, Angel M., additional, Roobol, Monique J., additional, Hugosson, Jonas, additional, Stephen Jones, J., additional, Kattan, Michael W., additional, Klein, Eric A., additional, Hamdy, Freddie, additional, Neal, David, additional, Donovan, Jenny, additional, Parekh, Dipen J., additional, Klocker, Helmut, additional, Horninger, Wolfgang, additional, Benchikh, Amine, additional, Salama, Gilles, additional, Villers, Arnauld, additional, Moreira, Daniel M., additional, Schröder, Fritz H., additional, Lilja, Hans, additional, and Vickers, Andrew J., additional

Published
2011
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34. Importance of prostate volume in the European Randomised Study of Screening for Prostate Cancer (ERSPC) risk calculators: results from the prostate biopsy collaborative group

Author

Roobol, Monique J., primary, Schröder, F. H., additional, Hugosson, Jonas, additional, Jones, J. Stephen, additional, Kattan, Michael W., additional, Klein, Eric A., additional, Hamdy, Freddie, additional, Neal, David, additional, Donovan, Jenny, additional, Parekh, Dipen J., additional, Ankerst, Donna, additional, Bartsch, George, additional, Klocker, Helmut, additional, Horninger, Wolfgang, additional, Benchikh, Amine, additional, Salama, Gilles, additional, Villers, Arnauld, additional, Freedland, Stephen J., additional, Moreira, Daniel M., additional, Vickers, Andrew J., additional, Lilja, Hans, additional, and Steyerberg, Ewout W., additional

Published
2011
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38. Polygenic hazard score is associated with prostate cancer in multi-ethnic populations

Author

Huynh-Le, Minh-Phuong, Fan, Chun Chieh, Karunamuni, Roshan, Thompson, Wesley K, Martinez, Maria Elena, Eeles, Rosalind A, Kote-Jarai, Zsofia, Muir, Kenneth, Schleutker, Johanna, Pashayan, Nora, Batra, Jyotsna, Grönberg, Henrik, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Nielsen, Sune F, Nordestgaard, Børge G, Wiklund, Fredrik, Tangen, Catherine M, Giles, Graham G, Wolk, Alicja, Albanes, Demetrius, Travis, Ruth C, Blot, William J, Zheng, Wei, Sanderson, Maureen, Stanford, Janet L, Mucci, Lorelei A, West, Catharine ML, Kibel, Adam S, Cussenot, Olivier, Berndt, Sonja I, Koutros, Stella, Sørensen, Karina Dalsgaard, Cybulski, Cezary, Grindedal, Eli Marie, Menegaux, Florence, Khaw, Kay-Tee, Park, Jong Y, Ingles, Sue A, Maier, Christiane, Hamilton, Robert J, Thibodeau, Stephen N, Rosenstein, Barry S, Lu, Yong-Jie, Watya, Stephen, Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L, Huff, Chad, Teixeira, Manuel R, Multigner, Luc, Leach, Robin J, Cannon-Albright, Lisa, Brenner, Hermann, John, Esther M, Kaneva, Radka, Logothetis, Christopher J, Neuhausen, Susan L, De Ruyck, Kim, Pandha, Hardev, Razack, Azad, Newcomb, Lisa F, Fowke, Jay H, Gamulin, Marija, Usmani, Nawaid, Claessens, Frank, Gago-Dominguez, Manuela, Townsend, Paul A, Bush, William S, Roobol, Monique J, Parent, Marie-Élise, Hu, Jennifer J, Mills, Ian G, Andreassen, Ole A, Dale, Anders M, Seibert, Tyler M, UKGPCS Collaborators, APCB (Australian Prostate Cancer BioResource), NC-LA PCaP Investigators, IMPACT Study Steering Committee And Collaborators, Canary PASS Investigators, Profile Study Steering Committee, and PRACTICAL Consortium

Subjects
Male, Multifactorial Inheritance, Multivariate Analysis, Ethnicity, Humans, Prostatic Neoplasms, Neoplasm Invasiveness, Self Report, Middle Aged, 3. Good health, Aged
Abstract

Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10-180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.

39. Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

Author

Conti, David V, Darst, Burcu F, Moss, Lilit C, Saunders, Edward J, Sheng, Xin, Chou, Alisha, Schumacher, Fredrick R, Olama, Ali Amin Al, Benlloch, Sara, Dadaev, Tokhir, Brook, Mark N, Sahimi, Ali, Hoffmann, Thomas J, Takahashi, Atushi, Matsuda, Koichi, Momozawa, Yukihide, Fujita, Masashi, Muir, Kenneth, Lophatananon, Artitaya, Wan, Peggy, Le Marchand, Loic, Wilkens, Lynne R, Stevens, Victoria L, Gapstur, Susan M, Carter, Brian D, Schleutker, Johanna, Tammela, Teuvo LJ, Sipeky, Csilla, Auvinen, Anssi, Giles, Graham G, Southey, Melissa C, MacInnis, Robert J, Cybulski, Cezary, Wokołorczyk, Dominika, Lubiński, Jan, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Nordestgaard, Børge G, Nielsen, Sune F, Weischer, Maren, Bojesen, Stig E, Røder, Martin Andreas, Iversen, Peter, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Horvath, Lisa, Clements, Judith A, Tilley, Wayne, Risbridger, Gail P, Gronberg, Henrik, Aly, Markus, Szulkin, Robert, Eklund, Martin, Nordström, Tobias, Pashayan, Nora, Dunning, Alison M, Ghoussaini, Maya, Travis, Ruth C, Key, Tim J, Riboli, Elio, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Albanes, Demetrius, Weinstein, Stephanie J, Mucci, Lorelei A, Giovannucci, Edward, Lindstrom, Sara, Kraft, Peter, Hunter, David J, Penney, Kathryn L, Turman, Constance, Tangen, Catherine M, Goodman, Phyllis J, Thompson, Ian M, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, Parent, Marie-Élise, Stanford, Janet L, Ostrander, Elaine A, Geybels, Milan S, Koutros, Stella, Freeman, Laura E Beane, Stampfer, Meir, Wolk, Alicja, Håkansson, Niclas, Andriole, Gerald L, Hoover, Robert N, Machiela, Mitchell J, Sørensen, Karina Dalsgaard, Borre, Michael, Blot, William J, Zheng, Wei, Yeboah, Edward D, Mensah, James E, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Wu, Yudong, Zhao, Shan-Chao, Sun, Zan, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, West, Catharine ML, Burnet, Neil, Barnett, Gill, Maier, Christiane, Schnoeller, Thomas, Luedeke, Manuel, Kibel, Adam S, Drake, Bettina F, Cussenot, Olivier, Cancel-Tassin, Géraldine, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, John, Esther M, Grindedal, Eli Marie, Maehle, Lovise, Khaw, Kay-Tee, Ingles, Sue A, Stern, Mariana C, Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Rosenstein, Barry S, Kerns, Sarah L, Ostrer, Harry, Teixeira, Manuel R, Paulo, Paula, Brandão, Andreia, Watya, Stephen, Lubwama, Alexander, Bensen, Jeannette T, Fontham, Elizabeth TH, Mohler, James, Taylor, Jack A, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Cannon-Albright, Lisa, Teerlink, Craig C, Huff, Chad D, Strom, Sara S, Multigner, Luc, Blanchet, Pascal, Brureau, Laurent, Kaneva, Radka, Slavov, Chavdar, Mitev, Vanio, Leach, Robin J, Weaver, Brandi, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Saum, Kai-Uwe, Klein, Eric A, Hsing, Ann W, Kittles, Rick A, Murphy, Adam B, Logothetis, Christopher J, Kim, Jeri, Neuhausen, Susan L, Steele, Linda, Ding, Yuan Chun, Isaacs, William B, Nemesure, Barbara, Hennis, Anselm JM, Carpten, John, Pandha, Hardev, Michael, Agnieszka, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Xu, Jianfeng, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Newcomb, Lisa F, Lin, Daniel W, Fowke, Jay H, Neslund-Dudas, Christine, Rybicki, Benjamin A, Gamulin, Marija, Lessel, Davor, Kulis, Tomislav, Usmani, Nawaid, Singhal, Sandeep, Parliament, Matthew, Claessens, Frank, Joniau, Steven, Van Den Broeck, Thomas, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Larkin, Samantha, Townsend, Paul A, Aukim-Hastie, Claire, Bush, William S, Aldrich, Melinda C, Crawford, Dana C, Srivastava, Shiv, Cullen, Jennifer C, Petrovics, Gyorgy, Casey, Graham, Roobol, Monique J, Jenster, Guido, Van Schaik, Ron HN, Hu, Jennifer J, Sanderson, Maureen, Varma, Rohit, McKean-Cowdin, Roberta, Torres, Mina, Mancuso, Nicholas, Berndt, Sonja I, Van Den Eeden, Stephen K, Easton, Douglas F, Chanock, Stephen J, Cook, Michael B, Wiklund, Fredrik, Nakagawa, Hidewaki, Witte, John S, Eeles, Rosalind A, Kote-Jarai, Zsofia, and Haiman, Christopher A

Subjects
Male, Genetic Loci, Risk Factors, Racial Groups, Odds Ratio, Humans, Prostatic Neoplasms, Genetic Predisposition to Disease, Molecular Sequence Annotation, Neoplasm Invasiveness, Middle Aged, 3. Good health, Genome-Wide Association Study
Abstract

Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The top genetic risk score (GRS) decile was associated with odds ratios that ranged from 5.06 (95% confidence interval (CI), 4.84-5.29) for men of European ancestry to 3.74 (95% CI, 3.36-4.17) for men of African ancestry. Men of African ancestry were estimated to have a mean GRS that was 2.18-times higher (95% CI, 2.14-2.22), and men of East Asian ancestry 0.73-times lower (95% CI, 0.71-0.76), than men of European ancestry. These findings support the role of germline variation contributing to population differences in prostate cancer risk, with the GRS offering an approach for personalized risk prediction.

40. Germline variation at 8q24 and prostate cancer risk in men of European ancestry

Author

Matejcic, Marco, Saunders, Edward J, Dadaev, Tokhir, Brook, Mark N, Wang, Kan, Sheng, Xin, Olama, Ali Amin Al, Schumacher, Fredrick R, Ingles, Sue A, Govindasami, Koveela, Benlloch, Sara, Berndt, Sonja I, Albanes, Demetrius, Koutros, Stella, Muir, Kenneth, Stevens, Victoria L, Gapstur, Susan M, Tangen, Catherine M, Batra, Jyotsna, Clements, Judith, Gronberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Wolk, Alicja, West, Catharine, Mucci, Lorelei, Kraft, Peter, Cancel-Tassin, Géraldine, Sorensen, Karina D, Maehle, Lovise, Grindedal, Eli M, Strom, Sara S, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Travis, Ruth C, Hamilton, Robert J, Rosenstein, Barry, Lu, Yong-Jie, Giles, Graham G, Kibel, Adam S, Vega, Ana, Bensen, Jeanette T, Kogevinas, Manolis, Penney, Kathryn L, Park, Jong Y, Stanford, Janet L, Cybulski, Cezary, Nordestgaard, Børge G, Brenner, Hermann, Maier, Christiane, Kim, Jeri, Teixeira, Manuel R, Neuhausen, Susan L, De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F, Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A, Gago-Dominguez, Manuela, Roobol, Monique J, Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa A, Pandha, Hardev, Thibodeau, Stephen N, Schaid, Daniel J, PRACTICAL (Prostate Cancer Association Group To Investigate Cancer-Associated Alterations In The Genome) Consortium, Wiklund, Fredrik, Chanock, Stephen J, Easton, Douglas F, Eeles, Rosalind A, Kote-Jarai, Zsofia, Conti, David V, and Haiman, Christopher A

Subjects
Genetic Markers, Male, Genotype, Chromosome Mapping, Prostatic Neoplasms, Risk Assessment, White People, 3. Good health, Haplotypes, Risk Factors, Case-Control Studies, Humans, Genetic Predisposition to Disease, Disease Susceptibility, Chromosomes, Human, Pair 8
Abstract

Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.

41. Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, DeFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, Ganz, Patricia A, Garber, Judy, García-Sáenz, José A, Gayther, Simon A, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Goode, Ellen L, Goodman, Marc T, Goodman, Gary, Grankvist, Kjell, Greene, Mark H, Gronberg, Henrik, Gronwald, Jacek, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C, Hamilton, Robert J, Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Høgdall, Estrid, Hong, Yun-Chul, Hopper, John L, Houlston, Richard, Hulick, Peter J, Hunter, David J, Huntsman, David G, Idos, Gregory, Imyanitov, Evgeny N, Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A, Johansson, Mattias, Johansson, Mikael, John, Esther M, Joshi, Amit D, Kaneva, Radka, Karlan, Beth Y, Kelemen, Linda E, Kühl, Tabea, Khaw, Kay-Tee, Khusnutdinova, Elza, Kibel, Adam S, Kiemeney, Lambertus A, Kim, Jeri, Kjaer, Susanne K, Knight, Julia A, Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N, Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D, Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz-Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A, Li, Li, Li, Christopher I, Lindblom, Annika, Lindor, Noralane M, Liu, Geoffrey, Loupakis, Fotios, Lubiński, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Marchand, Loic Le, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L, MacInnis, Robert J, Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B, Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L, Neal, David E, Ness, Andrew R, Neuhausen, Susan L, Nevanlinna, Heli, Newcomb, Polly A, Newcomb, Lisa F, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Børge G, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olama, Ali Amin Al, Olopade, Olufunmilayo I, Olshan, Andrew F, Olsson, Håkan, Osorio, Ana, Pandha, Hardev, Park, Jong Y, Pashayan, Nora, Parsons, Michael T, Pejovic, Tanja, Penney, Kathryn L, Peters, Wilbert HM, Phelan, Catherine M, Phipps, Amanda I, Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Van Rensburg, Elizabeth J, Riggan, Marjorie J, Risch, Harvey A, Risch, Angela, Roobol, Monique J, Rosenstein, Barry S, Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schabath, Matthew B, Schleutker, Johanna, Schmidt, Marjanka K, Setiawan, V Wendy, Shen, Hongbing, Siegel, Erin M, Sieh, Weiva, Singer, Christian F, Slattery, Martha L, Sorensen, Karina Dalsgaard, Southey, Melissa C, Spurdle, Amanda B, Stanford, Janet L, Stevens, Victoria L, Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J, Tajara, Eloiza H, Tangen, Catherine M, Tardon, Adonina, Taylor, Jack A, Teare, M Dawn, Teixeira, Manuel R, Terry, Mary Beth, Terry, Kathryn L, Thibodeau, Stephen N, Thomassen, Mads, Bjørge, Line, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Townsend, Paul A, Travis, Ruth C, Tung, Nadine, Tworoger, Shelley S, Ulrich, Cornelia M, Usmani, Nawaid, Vachon, Celine M, Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elías, Wang, Qin, Webb, Penelope M, Weinberg, Clarice R, Weinstein, Stephanie, Weissler, Mark C, Weitzel, Jeffrey N, West, Catharine ML, White, Emily, Whittemore, Alice S, Wichmann, H-Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H, Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K, Lane, Jacqueline M, Saxena, Richa, Thomas, Duncan, Hung, Rayjean J, Diergaarde, Brenda, McKay, James, Peters, Ulrike, Hsu, Li, García-Closas, Montserrat, Eeles, Rosalind A, Chenevix-Trench, Georgia, Brennan, Paul J, Haiman, Christopher A, Simard, Jacques, Easton, Douglas F, Gruber, Stephen B, Pharoah, Paul DP, Price, Alkes L, Pasaniuc, Bogdan, Amos, Christopher I, Kraft, Peter, and Lindström, Sara

Subjects
Male, Ovarian Neoplasms, Lung Neoplasms, Mental Disorders, Smoking, Inheritance Patterns, Prostatic Neoplasms, Breast Neoplasms, Polymorphism, Single Nucleotide, White People, 3. Good health, Neoplasm Proteins, Phenotype, Head and Neck Neoplasms, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Colorectal Neoplasms, Genome-Wide Association Study
Abstract

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

42. Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Author

Dadaev, Tokhir, Saunders, Edward J, Newcombe, Paul J, Anokian, Ezequiel, Leongamornlert, Daniel A, Brook, Mark N, Cieza-Borrella, Clara, Mijuskovic, Martina, Wakerell, Sarah, Olama, Ali Amin Al, Schumacher, Fredrick R, Berndt, Sonja I, Benlloch, Sara, Ahmed, Mahbubl, Goh, Chee, Sheng, Xin, Zhang, Zhuo, Muir, Kenneth, Govindasami, Koveela, Lophatananon, Artitaya, Stevens, Victoria L, Gapstur, Susan M, Carter, Brian D, Tangen, Catherine M, Goodman, Phyllis, Thompson, Ian M, Batra, Jyotsna, Chambers, Suzanne, Moya, Leire, Clements, Judith, Horvath, Lisa, Tilley, Wayne, Risbridger, Gail, Gronberg, Henrik, Aly, Markus, Nordström, Tobias, Pharoah, Paul, Pashayan, Nora, Schleutker, Johanna, Tammela, Teuvo LJ, Sipeky, Csilla, Auvinen, Anssi, Albanes, Demetrius, Weinstein, Stephanie, Wolk, Alicja, Hakansson, Niclas, West, Catharine, Dunning, Alison M, Burnet, Neil, Mucci, Lorelei, Giovannucci, Edward, Andriole, Gerald, Cussenot, Olivier, Cancel-Tassin, Géraldine, Koutros, Stella, Freeman, Laura E Beane, Sorensen, Karina Dalsgaard, Orntoft, Torben Falck, Borre, Michael, Maehle, Lovise, Grindedal, Eli Marie, Neal, David E, Donovan, Jenny L, Hamdy, Freddie C, Martin, Richard M, Travis, Ruth C, Key, Tim J, Hamilton, Robert J, Fleshner, Neil E, Finelli, Antonio, Ingles, Sue Ann, Stern, Mariana C, Rosenstein, Barry, Kerns, Sarah, Ostrer, Harry, Lu, Yong-Jie, Zhang, Hong-Wei, Feng, Ninghan, Mao, Xueying, Guo, Xin, Wang, Guomin, Sun, Zan, Giles, Graham G, Southey, Melissa C, MacInnis, Robert J, FitzGerald, Liesel M, Kibel, Adam S, Drake, Bettina F, Vega, Ana, Gómez-Caamaño, Antonio, Fachal, Laura, Szulkin, Robert, Eklund, Martin, Kogevinas, Manolis, Llorca, Javier, Castaño-Vinyals, Gemma, Penney, Kathryn L, Stampfer, Meir, Park, Jong Y, Sellers, Thomas A, Lin, Hui-Yi, Stanford, Janet L, Cybulski, Cezary, Wokolorczyk, Dominika, Lubinski, Jan, Ostrander, Elaine A, Geybels, Milan S, Nordestgaard, Børge G, Nielsen, Sune F, Weisher, Maren, Bisbjerg, Rasmus, Røder, Martin Andreas, Iversen, Peter, Brenner, Hermann, Cuk, Katarina, Holleczek, Bernd, Maier, Christiane, Luedeke, Manuel, Schnoeller, Thomas, Kim, Jeri, Logothetis, Christopher J, John, Esther M, Teixeira, Manuel R, Paulo, Paula, Cardoso, Marta, Neuhausen, Susan L, Steele, Linda, Ding, Yuan Chun, De Ruyck, Kim, De Meerleer, Gert, Ost, Piet, Razack, Azad, Lim, Jasmine, Teo, Soo-Hwang, Lin, Daniel W, Newcomb, Lisa F, Lessel, Davor, Gamulin, Marija, Kulis, Tomislav, Kaneva, Radka, Usmani, Nawaid, Slavov, Chavdar, Mitev, Vanio, Parliament, Matthew, Singhal, Sandeep, Claessens, Frank, Joniau, Steven, Van Den Broeck, Thomas, Larkin, Samantha, Townsend, Paul A, Aukim-Hastie, Claire, Gago-Dominguez, Manuela, Castelao, Jose Esteban, Martinez, Maria Elena, Roobol, Monique J, Jenster, Guido, Van Schaik, Ron HN, Menegaux, Florence, Truong, Thérèse, Koudou, Yves Akoli, Xu, Jianfeng, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Michael, Agnieszka, Kierzek, Andrzej, Thibodeau, Stephen N, McDonnell, Shannon K, Schaid, Daniel J, Lindstrom, Sara, Turman, Constance, Ma, Jing, Hunter, David J, Riboli, Elio, Siddiq, Afshan, Canzian, Federico, Kolonel, Laurence N, Le Marchand, Loic, Hoover, Robert N, Machiela, Mitchell J, Kraft, Peter, PRACTICAL (Prostate Cancer Association Group To Investigate Cancer-Associated Alterations In The Genome) Consortium, Freedman, Matthew, Wiklund, Fredrik, Chanock, Stephen, Henderson, Brian E, Easton, Douglas F, Haiman, Christopher A, Eeles, Rosalind A, Conti, David V, and Kote-Jarai, Zsofia

Subjects
Male, Risk, Quantitative Trait Loci, Black People, Chromosome Mapping, Prostatic Neoplasms, Bayes Theorem, Molecular Sequence Annotation, Polymorphism, Single Nucleotide, White People, 3. Good health, Multivariate Analysis, Humans, Genetic Predisposition to Disease, Algorithms, Genome-Wide Association Study
Abstract

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

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