1. Formation of N-Nitrosopyrrolidine in a Dog's Stomach
- Author
-
E L Wick, Paul M. Newberne, M C Archer, T S Mysliwy, and Ronald C. Shank
- Subjects
Absorption (pharmacology) ,Cancer Research ,Nitrosamines ,Pyrrolidines ,Time Factors ,education ,Catalysis ,Mass Spectrometry ,Pyrrolidine ,chemistry.chemical_compound ,Dogs ,In vivo ,Methods ,medicine ,Animals ,Sodium nitrite ,Nitrites ,N-Nitrosopyrrolidine ,Stomach ,digestive, oral, and skin physiology ,Articles ,Molecular biology ,medicine.anatomical_structure ,Oncology ,Biochemistry ,chemistry ,Gastric Mucosa - Abstract
The formation of N-nitrosopyrrolidine from sodium nitrite and pyrrolidine in vivo in a dog's stomach is demonstrated. The rate of formation of nitrosopyrrolidine is shown to be subject to pronounced catalytic effects. Nitrosopyrrolidine is also shown to disappear rapidly from the stomach, probably due to absorption.
- Published
- 1974
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