128 results on '"Rivadeneira, Fernando"'
Search Results
2. A meta-analysis of previous falls and subsequent fracture risk in cohort studies
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Vandenput, Liesbeth, primary, Johansson, Helena, additional, McCloskey, Eugene V., additional, Liu, Enwu, additional, Schini, Marian, additional, Åkesson, Kristina E., additional, Anderson, Fred A., additional, Azagra, Rafael, additional, Bager, Cecilie L., additional, Beaudart, Charlotte, additional, Bischoff-Ferrari, Heike A., additional, Biver, Emmanuel, additional, Bruyère, Olivier, additional, Cauley, Jane A., additional, Center, Jacqueline R., additional, Chapurlat, Roland, additional, Christiansen, Claus, additional, Cooper, Cyrus, additional, Crandall, Carolyn J., additional, Cummings, Steven R., additional, da Silva, José A. P., additional, Dawson-Hughes, Bess, additional, Diez-Perez, Adolfo, additional, Dufour, Alyssa B., additional, Eisman, John A., additional, Elders, Petra J. M., additional, Ferrari, Serge, additional, Fujita, Yuki, additional, Fujiwara, Saeko, additional, Glüer, Claus-Christian, additional, Goldshtein, Inbal, additional, Goltzman, David, additional, Gudnason, Vilmundur, additional, Hall, Jill, additional, Hans, Didier, additional, Hoff, Mari, additional, Hollick, Rosemary J., additional, Huisman, Martijn, additional, Iki, Masayuki, additional, Ish-Shalom, Sophia, additional, Jones, Graeme, additional, Karlsson, Magnus K., additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Koh, Woon-Puay, additional, Koromani, Fjorda, additional, Kotowicz, Mark A., additional, Kröger, Heikki, additional, Kwok, Timothy, additional, Lamy, Olivier, additional, Langhammer, Arnulf, additional, Larijani, Bagher, additional, Lippuner, Kurt, additional, McGuigan, Fiona E. A., additional, Mellström, Dan, additional, Merlijn, Thomas, additional, Nguyen, Tuan V., additional, Nordström, Anna, additional, Nordström, Peter, additional, O’Neill, Terence W., additional, Obermayer-Pietsch, Barbara, additional, Ohlsson, Claes, additional, Orwoll, Eric S., additional, Pasco, Julie A., additional, Rivadeneira, Fernando, additional, Schott, Anne-Marie, additional, Shiroma, Eric J., additional, Siggeirsdottir, Kristin, additional, Simonsick, Eleanor M., additional, Sornay-Rendu, Elisabeth, additional, Sund, Reijo, additional, Swart, Karin M. A., additional, Szulc, Pawel, additional, Tamaki, Junko, additional, Torgerson, David J., additional, van Schoor, Natasja M., additional, van Staa, Tjeerd P., additional, Vila, Joan, additional, Wareham, Nicholas J., additional, Wright, Nicole C., additional, Yoshimura, Noriko, additional, Zillikens, MCarola, additional, Zwart, Marta, additional, Harvey, Nicholas C., additional, Lorentzon, Mattias, additional, Leslie, William D., additional, and Kanis, John A., additional
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- 2024
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3. Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations
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Ghatan, Samuel, primary, van Rooij, Jeroen, additional, van Hoek, Mandy, additional, Boer, Cindy G., additional, Felix, Janine F., additional, Kavousi, Maryam, additional, Jaddoe, Vincent W., additional, Sijbrands, Eric J. G., additional, Medina-Gomez, Carolina, additional, Rivadeneira, Fernando, additional, and Oei, Ling, additional
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- 2024
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4. Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease
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Holstege, Henne, Hulsman, Marc, Charbonnier, Camille, Grenier-Boley, Benjamin, Quenez, Olivier, Grozeva, Detelina, van Rooij, Jeroen G. J., Sims, Rebecca, Ahmad, Shahzad, Amin, Najaf, Norsworthy, Penny J., Dols Icardo, Oriol, Hummerich, Holger, Kawalia, Amit, Amouyel, Philippe, Beecham, Gary W., Berr, Claudine, Bis, Joshua C., Boland, Anne, Bossù, Paola, Bouwman, Femke, Bras, Jose, Campion, Dominique, Cochran, J. Nicholas, Daniele, Antonio, Dartigues, Jean-François, Debette, Stéphanie, Deleuze, Jean-François, Denning, Nicola, DeStefano, Anita L., Farrer, Lindsay A., Fernández, Maria Victoria, Fox, Nick C., Galimberti, Daniela, Genin, Emmanuelle, Gille, Johan J. P., Le Guen, Yann, Guerreiro, Rita, Haines, Jonathan L., Holmes, Clive, Ikram, M. Arfan, Ikram, M. Kamran, Jansen, Iris E., Kraaij, Robert, Lathrop, Marc, Lemstra, Afina W., Lleó, Alberto, Luckcuck, Lauren, Mannens, Marcel M. A. M., Marshall, Rachel, Martin, Eden R., Masullo, Carlo, Mayeux, Richard, Mecocci, Patrizia, Meggy, Alun, Mol, Merel O., Morgan, Kevin, Myers, Richard M., Nacmias, Benedetta, Naj, Adam C., Napolioni, Valerio, Pasquier, Florence, Pastor, Pau, Pericak-Vance, Margaret A., Raybould, Rachel, Redon, Richard, Reinders, Marcel J. T., Richard, Anne-Claire, Riedel-Heller, Steffi G., Rivadeneira, Fernando, Rousseau, Stéphane, Ryan, Natalie S., Saad, Salha, Sánchez-Juan, Pascual, Schellenberg, Gerard D., Scheltens, Philip, Schott, Jonathan M., Seripa, Davide, Seshadri, Sudha, Sie, Daoud, Sistermans, Erik A., Sorbi, Sandro, van Spaendonk, Resie, Spalletta, Gianfranco, Tesi, Niccolo, Tijms, Betty, Uitterlinden, André G., van der Lee, Sven J., Visser, Pieter Jelle, Wagner, Michael, Wallon, David, Wang, Li-San, Zarea, Aline, Clarimón, Jordi, van Swieten, John C., Greicius, Michael D., Yokoyama, Jennifer S., Cruchaga, Carlos, Hardy, John, Ramirez, Alfredo, Mead, Simon, van der Flier, Wiesje M., van Duijn, Cornelia M., Williams, Julie, Nicolas, Gaël, Bellenguez, Céline, Lambert, Jean-Charles, Universitat Autònoma de Barcelona, Internal Medicine, Neurology, Epidemiology, Amsterdam Neuroscience - Neurodegeneration, VU University medical center, Human genetics, General practice, Amsterdam Neuroscience - Brain Imaging, APH - Personalized Medicine, APH - Methodology, Complex Trait Genetics, Human Genetics, and ACS - Pulmonary hypertension & thrombosis
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Adenosine Triphosphatases ,rare damaging variants ,Membrane Transport Proteins ,genetics [Alzheimer Disease] ,Alzheimer's disease ,ATP8B4 protein, human ,genetics [Adenosine Triphosphatases] ,genetics [Exosomes] ,Settore MED/26 - NEUROLOGIA ,SDG 3 - Good Health and Well-being ,Alzheimer Disease ,Risk Factors ,ddc:570 ,Genetics research ,ABCA1 protein, human ,Genetics ,SORL1 protein, human ,Humans ,genetics [ATP Binding Cassette Transporter 1] ,LDL-Receptor Related Proteins ,Genome-Wide Association Study ,ATP Binding Cassette Transporter 1 - Abstract
Alzheimer’s disease (AD), the leading cause of dementia, has an estimated heritability of approximately 70%1. The genetic component of AD has been mainly assessed using genome-wide association studies, which do not capture the risk contributed by rare variants2. Here, we compared the gene-based burden of rare damaging variants in exome sequencing data from 32,558 individuals—16,036 AD cases and 16,522 controls. Next to variants in TREM2, SORL1 and ABCA7, we observed a significant association of rare, predicted damaging variants in ATP8B4 and ABCA1 with AD risk, and a suggestive signal in ADAM10. Additionally, the rare-variant burden in RIN3, CLU, ZCWPW1 and ACE highlighted these genes as potential drivers of respective AD-genome-wide association study loci. Variants associated with the strongest effect on AD risk, in particular loss-of-function variants, are enriched in early-onset AD cases. Our results provide additional evidence for a major role for amyloid-β precursor protein processing, amyloid-β aggregation, lipid metabolism and microglial function in AD.
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- 2022
5. Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis
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Medina-Gomez, Carolina, primary, Mullin, Benjamin H., additional, Chesi, Alessandra, additional, Prijatelj, Vid, additional, Kemp, John P., additional, Shochat-Carvalho, Chen, additional, Trajanoska, Katerina, additional, Wang, Carol, additional, Joro, Raimo, additional, Evans, Tavia E., additional, Schraut, Katharina E., additional, Li-Gao, Ruifang, additional, Ahluwalia, Tarunveer S., additional, Zillikens, M. Carola, additional, Zhu, Kun, additional, Mook-Kanamori, Dennis O., additional, Evans, Daniel S., additional, Nethander, Maria, additional, Knol, Maria J., additional, Thorleifsson, Gudmar, additional, Prokic, Ivana, additional, Zemel, Babette, additional, Broer, Linda, additional, McGuigan, Fiona E., additional, van Schoor, Natasja M., additional, Reppe, Sjur, additional, Pawlak, Mikolaj A., additional, Ralston, Stuart H., additional, van der Velde, Nathalie, additional, Lorentzon, Mattias, additional, Stefansson, Kari, additional, Adams, Hieab H. H., additional, Wilson, Scott G., additional, Ikram, M. Arfan, additional, Walsh, John P., additional, Lakka, Timo A., additional, Gautvik, Kaare M., additional, Wilson, James F., additional, Orwoll, Eric S., additional, van Duijn, Cornelia M., additional, Bønnelykke, Klaus, additional, Uitterlinden, Andre G., additional, Styrkársdóttir, Unnur, additional, Akesson, Kristina E., additional, Spector, Timothy D., additional, Tobias, Jonathan H., additional, Ohlsson, Claes, additional, Felix, Janine F., additional, Bisgaard, Hans, additional, Grant, Struan F. A., additional, Richards, J. Brent, additional, Evans, David M., additional, van der Eerden, Bram, additional, van de Peppel, Jeroen, additional, Ackert-Bicknell, Cheryl, additional, Karasik, David, additional, Kague, Erika, additional, and Rivadeneira, Fernando, additional
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- 2023
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6. Oral and craniofacial research in the Generation R study: an executive summary
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van Meijeren-van Lunteren, Agatha W., primary, Liu, Xianjing, additional, Veenman, Francien C. H., additional, Grgic, Olja, additional, Dhamo, Brunilda, additional, van der Tas, Justin T., additional, Prijatelj, Vid, additional, Roshchupkin, Gennady V., additional, Rivadeneira, Fernando, additional, Wolvius, Eppo B., additional, and Kragt, Lea, additional
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- 2023
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7. Combining genome-wide association studies highlight novel loci involved in human facial variation
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Xiong, Ziyi, primary, Gao, Xingjian, additional, Chen, Yan, additional, Feng, Zhanying, additional, Pan, Siyu, additional, Lu, Haojie, additional, Uitterlinden, Andre G., additional, Nijsten, Tamar, additional, Ikram, Arfan, additional, Rivadeneira, Fernando, additional, Ghanbari, Mohsen, additional, Wang, Yong, additional, Kayser, Manfred, additional, and Liu, Fan, additional
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- 2022
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8. Plasma circulating microRNAs associated with obesity, body fat distribution, and fat mass: the Rotterdam Study
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Abozaid, Yasir J., primary, Zhang, Xiaofang, additional, Mens, Michelle M. J., additional, Ahmadizar, Fariba, additional, Limpens, Marlou, additional, Ikram, M. Arfan, additional, Rivadeneira, Fernando, additional, Voortman, Trudy, additional, Kavousi, Maryam, additional, and Ghanbari, Mohsen, additional
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- 2022
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9. Genome-wide association study identifies 48 common genetic variants associated with handedness
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Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, de Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O'Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, van Duijn, Cornelia M, van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, Waeber, Gérard, Wareham, Nicholas J, Warrington, Nicole, Waterworth, Dawn, Werge, Thomas, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F, Wright, Margaret J, Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A, Lindgren, Cecilia M, Mägi, Reedik, Neale, Benjamin M, Evans, David M, Medland, Sarah E, Cuellar-Partida, Gabriel [0000-0001-7648-4097], Aliev, Fazil [0000-0001-8357-4699], Andreassen, Ole A [0000-0002-4461-3568], Barroso, Inês [0000-0001-5800-4520], Beckmann, Jacques S [0000-0002-9741-1900], Boks, Marco P [0000-0001-6163-7484], Boomsma, Dorret I [0000-0002-7099-7972], Boyd, Heather A [0000-0001-6849-9985], Breteler, Monique MB [0000-0002-0626-9305], Chasman, Daniel I [0000-0003-3357-0862], de Geus, Eco JC [0000-0001-6022-2666], Deary, Ian J [0000-0002-1733-263X], Deloukas, Panos [0000-0001-9251-070X], Dick, Danielle M [0000-0002-1636-893X], Feenstra, Bjarke [0000-0003-1478-649X], Geller, Frank [0000-0002-9238-3269], Gordon, Scott D [0000-0001-7623-328X], Hansen, Thomas F [0000-0001-6703-7762], Hayward, Caroline [0000-0002-9405-9550], Hicks, Andrew A [0000-0001-6320-0411], Hirschhorn, Joel N [0000-0002-1650-7901], Hottenga, Jouke-Jan [0000-0002-5668-2368], Huffman, Jennifer E [0000-0002-9672-2491], Hwang, Liang-Dar [0000-0002-5535-2199], Ikram, M Arfan [0000-0003-0372-8585], Kaprio, Jaakko [0000-0002-3716-2455], Kemp, John P [0000-0002-9105-2249], Konte, Bettina [0000-0001-5287-308X], Kutalik, Zoltan [0000-0001-8285-7523], Lahti, Jari [0000-0002-4310-5297], Li, Xin [0000-0002-0135-8800], Loos, Ruth JF [0000-0002-8532-5087], Luciano, Michelle [0000-0002-7306-3008], Magnusson, Sigurdur H [0000-0001-6669-3071], Mangino, Massimo [0000-0002-2167-7470], Marques-Vidal, Pedro [0000-0002-4548-8500], Martin, Nicholas G [0000-0003-4069-8020], McArdle, Wendy L [0000-0002-0605-5403], McCarthy, Mark I [0000-0002-4393-0510], Medina-Gomez, Carolina [0000-0001-7999-5538], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Milani, Lili [0000-0002-5323-3102], Nelis, Mari [0000-0001-9748-1020], Nyholt, Dale R [0000-0001-7159-3040], O'Connell, Kevin S [0000-0002-6865-8795], Ophoff, Roel A [0000-0002-8287-6457], Palviainen, Teemu [0000-0002-7847-8384], Pare, Guillaume [0000-0002-6795-4760], Paternoster, Lavinia [0000-0003-2514-0889], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Ripatti, Samuli [0000-0002-0504-1202], Rivadeneira, Fernando [0000-0001-9435-9441], Rudan, Igor [0000-0001-6993-6884], Smit, Johannes H [0000-0002-2062-8378], Smith, George Davey [0000-0002-1407-8314], Smoller, Jordan W [0000-0002-0381-6334], Spector, Tim D [0000-0002-9795-0365], Pourcain, Beate St [0000-0002-4680-3517], Stefánsson, Hreinn [0000-0002-9331-6666], Steinberg, Stacy [0000-0001-7726-5152], Teder-Laving, Maris [0000-0002-5872-1850], Stefánsson, Kári [0000-0003-1676-864X], Timpson, Nicholas J [0000-0002-7141-9189], Uitterlinden, André G [0000-0002-7276-3387], van Rooij, Frank JA [0000-0002-8600-9852], Vink, Jaqueline M [0000-0003-3910-3528], Waeber, Gérard [0000-0003-4193-788X], Warrington, Nicole [0000-0003-4195-775X], Werge, Thomas [0000-0003-1829-0766], Wright, Margaret J [0000-0001-7133-4970], Zhao, Jing Hua [0000-0002-1463-5870], Kraft, Peter [0000-0002-4472-8103], Hinds, David A [0000-0002-4911-803X], Lindgren, Cecilia M [0000-0002-4903-9374], Neale, Benjamin M [0000-0003-1513-6077], Evans, David M [0000-0003-0663-4621], Medland, Sarah E [0000-0003-1382-380X], and Apollo - University of Cambridge Repository
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Adult ,Male ,Genetic Variation ,Middle Aged ,Polymorphism, Single Nucleotide ,Functional Laterality ,Linkage Disequilibrium ,Quantitative Trait, Heritable ,Sex Factors ,Gene Frequency ,Genetic Loci ,Humans ,Female ,Aged ,Genome-Wide Association Study - Abstract
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P
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- 2021
10. The health effects of vitamin D supplementation: evidence from human studies
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Bouillon, Roger, primary, Manousaki, Despoina, additional, Rosen, Cliff, additional, Trajanoska, Katerina, additional, Rivadeneira, Fernando, additional, and Richards, J. Brent, additional
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- 2021
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11. CYP11B1 variants influence skeletal maturation via alternative splicing
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Grgic, Olja, primary, Gazzara, Matthew R., additional, Chesi, Alessandra, additional, Medina-Gomez, Carolina, additional, Cousminer, Diana L., additional, Mitchell, Jonathan A., additional, Prijatelj, Vid, additional, de Vries, Jard, additional, Shevroja, Enisa, additional, McCormack, Shana E., additional, Kalkwarf, Heidi J., additional, Lappe, Joan M., additional, Gilsanz, Vicente, additional, Oberfield, Sharon E., additional, Shepherd, John A., additional, Kelly, Andrea, additional, Mahboubi, Soroosh, additional, Faucz, Fabio R., additional, Feelders, Richard A., additional, de Jong, Frank H., additional, Uitterlinden, Andre G., additional, Visser, Jenny A., additional, Ghanem, Louis R., additional, Wolvius, Eppo B., additional, Hofland, Leo J., additional, Stratakis, Constantine A., additional, Zemel, Babette S., additional, Barash, Yoseph, additional, Grant, Struan F. A., additional, and Rivadeneira, Fernando, additional
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- 2021
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12. A comparison of genotyping arrays
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Verlouw, Joost A. M., primary, Clemens, Eva, additional, de Vries, Jard H., additional, Zolk, Oliver, additional, Verkerk, Annemieke J. M. H., additional, am Zehnhoff-Dinnesen, Antoinette, additional, Medina-Gomez, Carolina, additional, Lanvers-Kaminsky, Claudia, additional, Rivadeneira, Fernando, additional, Langer, Thorsten, additional, van Meurs, Joyce B. J., additional, van den Heuvel-Eibrink, Marry M., additional, Uitterlinden, André G., additional, and Broer, Linda, additional
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- 2021
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13. Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease
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Youlten, Scott E., primary, Kemp, John P., additional, Logan, John G., additional, Ghirardello, Elena J., additional, Sergio, Claudio M., additional, Dack, Michael R. G., additional, Guilfoyle, Siobhan E., additional, Leitch, Victoria D., additional, Butterfield, Natalie C., additional, Komla-Ebri, Davide, additional, Chai, Ryan C., additional, Corr, Alexander P., additional, Smith, James T., additional, Mohanty, Sindhu T., additional, Morris, John A., additional, McDonald, Michelle M., additional, Quinn, Julian M. W., additional, McGlade, Amelia R., additional, Bartonicek, Nenad, additional, Jansson, Matt, additional, Hatzikotoulas, Konstantinos, additional, Irving, Melita D., additional, Beleza-Meireles, Ana, additional, Rivadeneira, Fernando, additional, Duncan, Emma, additional, Richards, J. Brent, additional, Adams, David J., additional, Lelliott, Christopher J., additional, Brink, Robert, additional, Phan, Tri Giang, additional, Eisman, John A., additional, Evans, David M., additional, Zeggini, Eleftheria, additional, Baldock, Paul A., additional, Bassett, J. H. Duncan, additional, Williams, Graham R., additional, and Croucher, Peter I., additional
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- 2021
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14. An atlas of genetic influences on osteoporosis in humans and mice
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Morris, John A, Kemp, John P, Youlten, Scott E, Laurent, Laetitia, Logan, John G, Chai, Ryan C, Vulpescu, Nicholas A, Forgetta, Vincenzo, Kleinman, Aaron, Mohanty, Sindhu T, Sergio, C Marcelo, Quinn, Julian, Nguyen-Yamamoto, Loan, Luco, Aimee-Lee, Vijay, Jinchu, Simon, Marie-Michelle, Pramatarova, Albena, Medina-Gomez, Carolina, Trajanoska, Katerina, Ghirardello, Elena J, Butterfield, Natalie C, Curry, Katharine F, Leitch, Victoria D, Sparkes, Penny C, Adoum, Anne-Tounsia, Mannan, Naila S, Komla-Ebri, Davide SK, Pollard, Andrea S, Dewhurst, Hannah F, Hassall, Thomas AD, Beltejar, Michael-John G, 23andMe Research Team, Adams, Douglas J, Vaillancourt, Suzanne M, Kaptoge, Stephen, Baldock, Paul, Cooper, Cyrus, Reeve, Jonathan, Ntzani, Evangelia E, Evangelou, Evangelos, Ohlsson, Claes, Karasik, David, Rivadeneira, Fernando, Kiel, Douglas P, Tobias, Jonathan H, Gregson, Celia L, Harvey, Nicholas C, Grundberg, Elin, Goltzman, David, Adams, David J, Lelliott, Christopher J, Hinds, David A, Ackert-Bicknell, Cheryl L, Hsu, Yi-Hsiang, Maurano, Matthew T, Croucher, Peter I, Williams, Graham R, Bassett, JH Duncan, Evans, David M, Richards, J Brent, Morris, John A [0000-0003-2769-8202], Kemp, John P [0000-0002-9105-2249], Youlten, Scott E [0000-0001-9314-2945], Vulpescu, Nicholas A [0000-0003-1310-0257], Sergio, C Marcelo [0000-0002-5426-0583], Medina-Gomez, Carolina [0000-0001-7999-5538], Reeve, Jonathan [0000-0002-4364-2682], Ntzani, Evangelia E [0000-0003-3712-4181], Rivadeneira, Fernando [0000-0001-9435-9441], Kiel, Douglas P [0000-0001-8474-0310], Gregson, Celia L [0000-0001-6414-0529], Harvey, Nicholas C [0000-0002-8194-2512], Lelliott, Christopher J [0000-0001-8087-4530], Hinds, David A [0000-0002-4911-803X], Williams, Graham R [0000-0002-8555-8219], Bassett, JH Duncan [0000-0003-0817-0082], Evans, David M [0000-0003-0663-4621], Richards, J Brent [0000-0002-3746-9086], and Apollo - University of Cambridge Repository
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Adult ,Male ,Mice, Knockout ,Middle Aged ,Polymorphism, Single Nucleotide ,Fractures, Bone ,Mice ,Phenotype ,Bone Density ,Animals ,Humans ,Osteoporosis ,Female ,Genetic Predisposition to Disease ,Aged ,Genome-Wide Association Study - Abstract
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative ultrasound in 426,824 individuals, identifying 518 genome-wide significant loci (301 novel), explaining 20% of its variance. We identified 13 bone fracture loci, all associated with estimated BMD (eBMD), in ~1.2 million individuals. We then identified target genes enriched for genes known to influence bone density and strength (maximum odds ratio (OR) = 58, P = 1 × 10-75) from cell-specific features, including chromatin conformation and accessible chromatin sites. We next performed rapid-throughput skeletal phenotyping of 126 knockout mice with disruptions in predicted target genes and found an increased abnormal skeletal phenotype frequency compared to 526 unselected lines (P < 0.0001). In-depth analysis of one gene, DAAM2, showed a disproportionate decrease in bone strength relative to mineralization. This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.
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- 2019
15. Genome-wide association study identifies 48 common genetic variants associated with handedness
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Cuellar-Partida, Gabriel, Tung, Joyce Y, Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A, Barroso, Inês, Beckmann, Jacques S, Boks, Marco P, Boomsma, Dorret I, Boyd, Heather A, Breteler, Monique MB, Campbell, Harry, Chasman, Daniel I, Cherkas, Lynn F, Davies, Gail, De Geus, Eco JC, Deary, Ian J, Deloukas, Panos, Dick, Danielle M, Duffy, David L, Eriksson, Johan G, Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D, Han, Jiali, Hansen, Thomas F, Hartmann, Annette M, Hayward, Caroline, Heikkilä, Kauko, Hicks, Andrew A, Hirschhorn, Joel N, Hottenga, Jouke-Jan, Huffman, Jennifer E, Hwang, Liang-Dar, Ikram, M Arfan, Kaprio, Jaakko, Kemp, John P, Khaw, Kay-Tee, Klopp, Norman, Konte, Bettina, Kutalik, Zoltan, Lahti, Jari, Li, Xin, Loos, Ruth JF, Luciano, Michelle, Magnusson, Sigurdur H, Mangino, Massimo, Marques-Vidal, Pedro, Martin, Nicholas G, McArdle, Wendy L, McCarthy, Mark I, Medina-Gomez, Carolina, Melbye, Mads, Melville, Scott A, Metspalu, Andres, Milani, Lili, Mooser, Vincent, Nelis, Mari, Nyholt, Dale R, O'Connell, Kevin S, Ophoff, Roel A, Palmer, Cameron, Palotie, Aarno, Palviainen, Teemu, Pare, Guillaume, Paternoster, Lavinia, Peltonen, Leena, Penninx, Brenda WJH, Polasek, Ozren, Pramstaller, Peter P, Prokopenko, Inga, Raikkonen, Katri, Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rujescu, Dan, Smit, Johannes H, Smith, George Davey, Smoller, Jordan W, Soranzo, Nicole, Spector, Tim D, Pourcain, Beate St, Starr, John M, Stefánsson, Hreinn, Steinberg, Stacy, Teder-Laving, Maris, Thorleifsson, Gudmar, Stefánsson, Kári, Timpson, Nicholas J, Uitterlinden, André G, Van Duijn, Cornelia M, Van Rooij, Frank JA, Vink, Jaqueline M, Vollenweider, Peter, Vuoksimaa, Eero, Waeber, Gérard, Wareham, Nicholas J, Warrington, Nicole, Waterworth, Dawn, Werge, Thomas, Wichmann, H-Erich, Widen, Elisabeth, Willemsen, Gonneke, Wright, Alan F, Wright, Margaret J, Xu, Mousheng, Zhao, Jing Hua, Kraft, Peter, Hinds, David A, Lindgren, Cecilia M, Mägi, Reedik, Neale, Benjamin M, Evans, David M, and Medland, Sarah E
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Adult ,Male ,Genetic Variation ,Middle Aged ,Polymorphism, Single Nucleotide ,Functional Laterality ,Linkage Disequilibrium ,Quantitative Trait, Heritable ,Sex Factors ,Gene Frequency ,Genetic Loci ,Humans ,Female ,Aged ,Genome-Wide Association Study - Abstract
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 × 10-8) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (rG = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.
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- 2020
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16. Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
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Jones, Garan, primary, Trajanoska, Katerina, additional, Santanasto, Adam J., additional, Stringa, Najada, additional, Kuo, Chia-Ling, additional, Atkins, Janice L., additional, Lewis, Joshua R., additional, Duong, ThuyVy, additional, Hong, Shengjun, additional, Biggs, Mary L., additional, Luan, Jian’an, additional, Sarnowski, Chloe, additional, Lunetta, Kathryn L., additional, Tanaka, Toshiko, additional, Wojczynski, Mary K., additional, Cvejkus, Ryan, additional, Nethander, Maria, additional, Ghasemi, Sahar, additional, Yang, Jingyun, additional, Zillikens, M. Carola, additional, Walter, Stefan, additional, Sicinski, Kamil, additional, Kague, Erika, additional, Ackert-Bicknell, Cheryl L., additional, Arking, Dan E., additional, Windham, B. Gwen, additional, Boerwinkle, Eric, additional, Grove, Megan L., additional, Graff, Misa, additional, Spira, Dominik, additional, Demuth, Ilja, additional, van der Velde, Nathalie, additional, de Groot, Lisette C. P. G. M., additional, Psaty, Bruce M., additional, Odden, Michelle C., additional, Fohner, Alison E., additional, Langenberg, Claudia, additional, Wareham, Nicholas J., additional, Bandinelli, Stefania, additional, van Schoor, Natasja M., additional, Huisman, Martijn, additional, Tan, Qihua, additional, Zmuda, Joseph, additional, Mellström, Dan, additional, Karlsson, Magnus, additional, Bennett, David A., additional, Buchman, Aron S., additional, De Jager, Philip L., additional, Uitterlinden, Andre G., additional, Völker, Uwe, additional, Kocher, Thomas, additional, Teumer, Alexander, additional, Rodriguéz-Mañas, Leocadio, additional, García, Francisco J., additional, Carnicero, José A., additional, Herd, Pamela, additional, Bertram, Lars, additional, Ohlsson, Claes, additional, Murabito, Joanne M., additional, Melzer, David, additional, Kuchel, George A., additional, Ferrucci, Luigi, additional, Karasik, David, additional, Rivadeneira, Fernando, additional, Kiel, Douglas P., additional, and Pilling, Luke C., additional
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- 2021
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17. Large-scale association analyses identify host factors influencing human gut microbiome composition
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Kurilshikov, Alexander, primary, Medina-Gomez, Carolina, additional, Bacigalupe, Rodrigo, additional, Radjabzadeh, Djawad, additional, Wang, Jun, additional, Demirkan, Ayse, additional, Le Roy, Caroline I., additional, Raygoza Garay, Juan Antonio, additional, Finnicum, Casey T., additional, Liu, Xingrong, additional, Zhernakova, Daria V., additional, Bonder, Marc Jan, additional, Hansen, Tue H., additional, Frost, Fabian, additional, Rühlemann, Malte C., additional, Turpin, Williams, additional, Moon, Jee-Young, additional, Kim, Han-Na, additional, Lüll, Kreete, additional, Barkan, Elad, additional, Shah, Shiraz A., additional, Fornage, Myriam, additional, Szopinska-Tokov, Joanna, additional, Wallen, Zachary D., additional, Borisevich, Dmitrii, additional, Agreus, Lars, additional, Andreasson, Anna, additional, Bang, Corinna, additional, Bedrani, Larbi, additional, Bell, Jordana T., additional, Bisgaard, Hans, additional, Boehnke, Michael, additional, Boomsma, Dorret I., additional, Burk, Robert D., additional, Claringbould, Annique, additional, Croitoru, Kenneth, additional, Davies, Gareth E., additional, van Duijn, Cornelia M., additional, Duijts, Liesbeth, additional, Falony, Gwen, additional, Fu, Jingyuan, additional, van der Graaf, Adriaan, additional, Hansen, Torben, additional, Homuth, Georg, additional, Hughes, David A., additional, Ijzerman, Richard G., additional, Jackson, Matthew A., additional, Jaddoe, Vincent W. V., additional, Joossens, Marie, additional, Jørgensen, Torben, additional, Keszthelyi, Daniel, additional, Knight, Rob, additional, Laakso, Markku, additional, Laudes, Matthias, additional, Launer, Lenore J., additional, Lieb, Wolfgang, additional, Lusis, Aldons J., additional, Masclee, Ad A. M., additional, Moll, Henriette A., additional, Mujagic, Zlatan, additional, Qibin, Qi, additional, Rothschild, Daphna, additional, Shin, Hocheol, additional, Sørensen, Søren J., additional, Steves, Claire J., additional, Thorsen, Jonathan, additional, Timpson, Nicholas J., additional, Tito, Raul Y., additional, Vieira-Silva, Sara, additional, Völker, Uwe, additional, Völzke, Henry, additional, Võsa, Urmo, additional, Wade, Kaitlin H., additional, Walter, Susanna, additional, Watanabe, Kyoko, additional, Weiss, Stefan, additional, Weiss, Frank U., additional, Weissbrod, Omer, additional, Westra, Harm-Jan, additional, Willemsen, Gonneke, additional, Payami, Haydeh, additional, Jonkers, Daisy M. A. E., additional, Arias Vasquez, Alejandro, additional, de Geus, Eco J. C., additional, Meyer, Katie A., additional, Stokholm, Jakob, additional, Segal, Eran, additional, Org, Elin, additional, Wijmenga, Cisca, additional, Kim, Hyung-Lae, additional, Kaplan, Robert C., additional, Spector, Tim D., additional, Uitterlinden, Andre G., additional, Rivadeneira, Fernando, additional, Franke, Andre, additional, Lerch, Markus M., additional, Franke, Lude, additional, Sanna, Serena, additional, D’Amato, Mauro, additional, Pedersen, Oluf, additional, Paterson, Andrew D., additional, Kraaij, Robert, additional, Raes, Jeroen, additional, and Zhernakova, Alexandra, additional
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- 2021
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18. Type 2 Diabetes Mellitus and Vertebral Fracture Risk
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Koromani, Fjorda, primary, Ghatan, Samuel, additional, van Hoek, Mandy, additional, Zillikens, M. Carola, additional, Oei, Edwin H. G., additional, Rivadeneira, Fernando, additional, and Oei, Ling, additional
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- 2021
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19. Genetic basis of falling risk susceptibility in the UK Biobank Study
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Trajanoska, Katerina, primary, Seppala, Lotta J., additional, Medina-Gomez, Carolina, additional, Hsu, Yi-Hsiang, additional, Zhou, Sirui, additional, van Schoor, Natasja M., additional, de Groot, Lisette C. P. G. M., additional, Karasik, David, additional, Richards, J. Brent, additional, Kiel, Douglas P., additional, Uitterlinden, Andre G., additional, Perry, John R. B., additional, van der Velde, Nathalie, additional, Day, Felix R., additional, and Rivadeneira, Fernando, additional
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- 2020
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20. Genome-wide association study identifies 48 common genetic variants associated with handedness
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Cuellar-Partida, Gabriel, primary, Tung, Joyce Y., additional, Eriksson, Nicholas, additional, Albrecht, Eva, additional, Aliev, Fazil, additional, Andreassen, Ole A., additional, Barroso, Inês, additional, Beckmann, Jacques S., additional, Boks, Marco P., additional, Boomsma, Dorret I., additional, Boyd, Heather A., additional, Breteler, Monique M. B., additional, Campbell, Harry, additional, Chasman, Daniel I., additional, Cherkas, Lynn F., additional, Davies, Gail, additional, de Geus, Eco J. C., additional, Deary, Ian J., additional, Deloukas, Panos, additional, Dick, Danielle M., additional, Duffy, David L., additional, Eriksson, Johan G., additional, Esko, Tõnu, additional, Feenstra, Bjarke, additional, Geller, Frank, additional, Gieger, Christian, additional, Giegling, Ina, additional, Gordon, Scott D., additional, Han, Jiali, additional, Hansen, Thomas F., additional, Hartmann, Annette M., additional, Hayward, Caroline, additional, Heikkilä, Kauko, additional, Hicks, Andrew A., additional, Hirschhorn, Joel N., additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E., additional, Hwang, Liang-Dar, additional, Ikram, M. Arfan, additional, Kaprio, Jaakko, additional, Kemp, John P., additional, Khaw, Kay-Tee, additional, Klopp, Norman, additional, Konte, Bettina, additional, Kutalik, Zoltan, additional, Lahti, Jari, additional, Li, Xin, additional, Loos, Ruth J. F., additional, Luciano, Michelle, additional, Magnusson, Sigurdur H., additional, Mangino, Massimo, additional, Marques-Vidal, Pedro, additional, Martin, Nicholas G., additional, McArdle, Wendy L., additional, McCarthy, Mark I., additional, Medina-Gomez, Carolina, additional, Melbye, Mads, additional, Melville, Scott A., additional, Metspalu, Andres, additional, Milani, Lili, additional, Mooser, Vincent, additional, Nelis, Mari, additional, Nyholt, Dale R., additional, O’Connell, Kevin S., additional, Ophoff, Roel A., additional, Palmer, Cameron, additional, Palotie, Aarno, additional, Palviainen, Teemu, additional, Pare, Guillaume, additional, Paternoster, Lavinia, additional, Peltonen, Leena, additional, Penninx, Brenda W. J. H., additional, Polasek, Ozren, additional, Pramstaller, Peter P., additional, Prokopenko, Inga, additional, Raikkonen, Katri, additional, Ripatti, Samuli, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Rujescu, Dan, additional, Smit, Johannes H., additional, Smith, George Davey, additional, Smoller, Jordan W., additional, Soranzo, Nicole, additional, Spector, Tim D., additional, Pourcain, Beate St, additional, Starr, John M., additional, Stefánsson, Hreinn, additional, Steinberg, Stacy, additional, Teder-Laving, Maris, additional, Thorleifsson, Gudmar, additional, Stefánsson, Kári, additional, Timpson, Nicholas J., additional, Uitterlinden, André G., additional, van Duijn, Cornelia M., additional, van Rooij, Frank J. A., additional, Vink, Jaqueline M., additional, Vollenweider, Peter, additional, Vuoksimaa, Eero, additional, Waeber, Gérard, additional, Wareham, Nicholas J., additional, Warrington, Nicole, additional, Waterworth, Dawn, additional, Werge, Thomas, additional, Wichmann, H.-Erich, additional, Widen, Elisabeth, additional, Willemsen, Gonneke, additional, Wright, Alan F., additional, Wright, Margaret J., additional, Xu, Mousheng, additional, Zhao, Jing Hua, additional, Kraft, Peter, additional, Hinds, David A., additional, Lindgren, Cecilia M., additional, Mägi, Reedik, additional, Neale, Benjamin M., additional, Evans, David M., additional, and Medland, Sarah E., additional
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- 2020
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21. Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood
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Zheng, Yan, primary, Huang, Tao, additional, Wang, Tiange, additional, Mei, Zhendong, additional, Sun, Zhonghan, additional, Zhang, Tao, additional, Ellervik, Christina, additional, Chai, Jin-Fang, additional, Sim, Xueling, additional, van Dam, Rob M., additional, Tai, E-Shyong, additional, Koh, Woon-Puay, additional, Dorajoo, Rajkumar, additional, Saw, Seang-Mei, additional, Sabanayagam, Charumathi, additional, Wong, Tien Yin, additional, Gupta, Preeti, additional, Rossing, Peter, additional, Ahluwalia, Tarunveer S., additional, Vinding, Rebecca K., additional, Bisgaard, Hans, additional, Bønnelykke, Klaus, additional, Wang, Yujie, additional, Graff, Mariaelisa, additional, Voortman, Trudy, additional, van Rooij, Frank J. A., additional, Hofman, Albert, additional, van Heemst, Diana, additional, Noordam, Raymond, additional, Estampador, Angela C., additional, Varga, Tibor V., additional, Enzenbach, Cornelia, additional, Scholz, Markus, additional, Thiery, Joachim, additional, Burkhardt, Ralph, additional, Orho-Melander, Marju, additional, Schulz, Christina-Alexandra, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Kubo, Michiaki, additional, Akiyama, Masato, additional, Zhou, Ang, additional, Kilpeläinen, Tuomas O., additional, Hansen, Torben, additional, Kleber, Marcus E., additional, Delgado, Graciela, additional, McCarthy, Mark, additional, Lemaitre, Rozenn N., additional, Felix, Janine F., additional, Jaddoe, Vincent W. V., additional, Wu, Ying, additional, Mohlke, Karen L., additional, Lehtimäki, Terho, additional, Wang, Carol A., additional, Pennell, Craig E., additional, Schunkert, Heribert, additional, Kessler, Thorsten, additional, Zeng, Lingyao, additional, Willenborg, Christina, additional, Peters, Annette, additional, Lieb, Wolfgang, additional, Grote, Veit, additional, Rzehak, Peter, additional, Koletzko, Berthold, additional, Erdmann, Jeanette, additional, Munz, Matthias, additional, Wu, Tangchun, additional, He, Meian, additional, Yu, Caizheng, additional, Lecoeur, Cécile, additional, Froguel, Philippe, additional, Corella, Dolores, additional, Moreno, Luis A., additional, Lai, Chao-Qiang, additional, Pitkänen, Niina, additional, Boreham, Colin A., additional, Ridker, Paul M., additional, Rosendaal, Frits R., additional, de Mutsert, Renée, additional, Power, Chris, additional, Paternoster, Lavinia, additional, Sørensen, Thorkild I. A., additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Djousse, Luc, additional, Rivadeneira, Fernando, additional, Lee, Nanette R., additional, Raitakari, Olli T., additional, Kähönen, Mika, additional, Viikari, Jorma, additional, Langhendries, Jean-Paul, additional, Escribano, Joaquin, additional, Verduci, Elvira, additional, Dedoussis, George, additional, König, Inke, additional, Balkau, Beverley, additional, Coltell, Oscar, additional, Dallongeville, Jean, additional, Meirhaeghe, Aline, additional, Amouyel, Philippe, additional, Gottrand, Frédéric, additional, Pahkala, Katja, additional, Niinikoski, Harri, additional, Hyppönen, Elina, additional, März, Winfried, additional, Mackey, David A., additional, Gruszfeld, Dariusz, additional, Tucker, Katherine L., additional, Fumeron, Frédéric, additional, Estruch, Ramon, additional, Ordovas, Jose M., additional, Arnett, Donna K., additional, Mook-Kanamori, Dennis O., additional, Mozaffarian, Dariush, additional, Psaty, Bruce M., additional, North, Kari E., additional, Chasman, Daniel I., additional, and Qi, Lu, additional
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- 2020
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22. Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study
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Magnus, Maria C., primary, Guyatt, Anna L., additional, Lawn, Rebecca B., additional, Wyss, Annah B., additional, Trajanoska, Katerina, additional, Küpers, Leanne K., additional, Rivadeneira, Fernando, additional, Tobin, Martin D., additional, London, Stephanie J., additional, Lawlor, Debbie A., additional, Millard, Louise A. C., additional, and Fraser, Abigail, additional
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- 2020
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23. Diversity, compositional and functional differences between gut microbiota of children and adults
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Radjabzadeh, Djawad, primary, Boer, Cindy G., additional, Beth, Sanne A., additional, van der Wal, Pelle, additional, Kiefte-De Jong, Jessica C., additional, Jansen, Michelle A. E., additional, Konstantinov, Sergey R., additional, Peppelenbosch, Maikel P., additional, Hays, John P., additional, Jaddoe, Vincent W. V., additional, Ikram, M. Arfan, additional, Rivadeneira, Fernando, additional, van Meurs, Joyce B. J., additional, Uitterlinden, André G., additional, Medina-Gomez, Carolina, additional, Moll, Henriette A., additional, and Kraaij, Robert, additional
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- 2020
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24. Macronutrient intake and frailty: the Rotterdam Study
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Verspoor, Eline, primary, Voortman, Trudy, additional, van Rooij, Frank J. A., additional, Rivadeneira, Fernando, additional, Franco, Oscar H., additional, Kiefte-de Jong, Jessica C., additional, and Schoufour, Josje D., additional
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- 2019
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25. No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs
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Geissler, Julia M, Romanos, Marcel, Sheerin, Una-Marie, Scheffer, Hans, Shaw, Karen, Shoulson, Ira, Sidransky, Ellen, Smith, Colin, Spencer, Chris C A, Stefánsson, Hreinn, Steinberg, Stacy, Stockton, Joanna D, Strange, Amy, Saad, Mohamad, Talbot, Kevin, Tanner, Carlie M, Tashakkori-Ghanbaria, Avazeh, Tison, François, Trabzuni, Daniah, Traynor, Bryan J, Uitterlinden, André G, Velseboer, Daan, Vidailhet, Marie, Walker, Robert, Simón-Sánchez, Javier, van de Warrenburg, Bart, Wickremaratchi, Mirdhu, Williams, Nigel, Williams-Gray, Caroline H, Winder-Rhodes, Sophie, Stefánsson, Kári, Martinez, Maria, Hardy, John, Heutink, Peter, Brice, Alexis, Schulte, Claudia, Gasser, Thomas, Singleton, Andrew B, Wood, Nicholas W, Lesage, Suzanne, Sveinbjörnsdóttir, Sigurlaug, Arepalli, Sampath, Barker, Roger, Ben-Shlomo, Yoav, Berendse, Henk W, Gerlach, Manfred, Berg, Daniela, Bhatia, Kailash, de Bie, Rob M A, Biffi, Alessandro, Bloem, Bas, Bochdanovits, Zoltan, Bonin, Michael, Bras, Jose M, Brockmann, Kathrin, Brooks, Janet, Burn, David J, Charlesworth, Gavin, Chen, Honglei, Chinnery, Patrick F, Chong, Sean, Clarke, Carl E, Cookson, Mark R, Cooper, J Mark, Corvol, Jean Christophe, Counsell, Carl, Damier, Philippe, Dartigues, Jean-François, Deloukas, Panos, Deuschl, Günther, Dexter, David T, van Dijk, Karin D, Dillman, Allissa, Durif, Frank, Dürr, Alexandra, Edkins, Sarah, members, International Parkinson Disease Genomics Consortium, Evans, Jonathan R, Foltynie, Thomas, Gao, Jianjun, Gardner, Michelle, Gibbs, J Raphael, Goate, Alison, Gray, Emma, Guerreiro, Rita, Gústafsson, Ómar, Harris, Clare, Nalls, Mike, van Hilten, Jacobus J, Hofman, Albert, Hollenbeck, Albert, Holton, Janice, Hu, Michele, Huang, Xuemei, Huber, Heiko, Hudson, Gavin, Hunt, Sarah E, Huttenlocher, Johanna, Plagnol, Vincent, Illig, Thomas, Jónsson, Pálmi V, Lambert, Jean-Charles, Langford, Cordelia, Lees, Andrew, Lichtner, Peter, Limousin, Patricia, Lopez, Grisel, Lorenz, Delia, McNeill, Alisdair, Hernandez, Dena G, Moorby, Catriona, Moore, Matthew, Morris, Huw R, Morrison, Karen E, Mudanohwo, Ese, O'Sullivan, Sean S, Pearson, Justin, Perlmutter, Joel S, Pétursson, Hjörvar, Pollak, Pierre, Sharma, Manu, Post, Bart, Potter, Simon, Ravina, Bernard, Revesz, Tamas, Riess, Olaf, Rivadeneira, Fernando, Rizzu, Patrizia, Ryten, Mina, Sawcer, Stephen, Schapira, Anthony, Human genetics, Neurology, Amsterdam Neuroscience - Neurodegeneration, Geissler, Julia M [0000-0003-1878-9647], and Apollo - University of Cambridge Repository
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0301 basic medicine ,Parkinson's disease ,Single-nucleotide polymorphism ,Genome-wide association study ,genetics [Attention Deficit Disorder with Hyperactivity] ,Polymorphism, Single Nucleotide ,Article ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,genetics [Parkinson Disease] ,medicine ,Attention deficit hyperactivity disorder ,ADHD ,GWAS ,Humans ,Genetic Predisposition to Disease ,ddc:610 ,genetics [Genetic Predisposition to Disease] ,Genetic Association Studies ,Genetic association ,Dopamine transporter ,Genetics ,TPH2 ,biology ,Parkinson Disease ,General Medicine ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,medicine.disease ,Psychiatry and Mental health ,Clinical Psychology ,030104 developmental biology ,Norepinephrine transporter ,Attention Deficit Disorder with Hyperactivity ,biology.protein ,genetics [Polymorphism, Single Nucleotide] ,Parkinson’s disease ,Psychology ,030217 neurology & neurosurgery ,CDH13 ,SNPs - Abstract
Item does not contain fulltext Attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD.
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- 2018
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26. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
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Jiang, Xia, O'Reilly, Paul F, Aschard, Hugues, Hsu, Yi-Hsiang, Richards, J Brent, Dupuis, Josée, Ingelsson, Erik, Karasik, David, Pilz, Stefan, Berry, Diane, Kestenbaum, Bryan, Zheng, Jusheng, Luan, Jianan, Sofianopoulou, Eleni, Streeten, Elizabeth A, Albanes, Demetrius, Lutsey, Pamela L, Yao, Lu, Tang, Weihong, Econs, Michael J, Wallaschofski, Henri, Völzke, Henry, Zhou, Ang, Power, Chris, McCarthy, Mark I, Michos, Erin D, Boerwinkle, Eric, Weinstein, Stephanie J, Freedman, Neal D, Huang, Wen-Yi, Van Schoor, Natasja M, Van Der Velde, Nathalie, Groot, Lisette CPGM De, Enneman, Anke, Cupples, L Adrienne, Booth, Sarah L, Vasan, Ramachandran S, Liu, Ching-Ti, Zhou, Yanhua, Ripatti, Samuli, Ohlsson, Claes, Vandenput, Liesbeth, Lorentzon, Mattias, Eriksson, Johan G, Shea, M Kyla, Houston, Denise K, Kritchevsky, Stephen B, Liu, Yongmei, Lohman, Kurt K, Ferrucci, Luigi, Peacock, Munro, Gieger, Christian, Beekman, Marian, Slagboom, Eline, Deelen, Joris, Heemst, Diana Van, Kleber, Marcus E, März, Winfried, De Boer, Ian H, Wood, Alexis C, Rotter, Jerome I, Rich, Stephen S, Robinson-Cohen, Cassianne, Den Heijer, Martin, Jarvelin, Marjo-Riitta, Cavadino, Alana, Joshi, Peter K, Wilson, James F, Hayward, Caroline, Lind, Lars, Michaëlsson, Karl, Trompet, Stella, Zillikens, M Carola, Uitterlinden, Andre G, Rivadeneira, Fernando, Broer, Linda, Zgaga, Lina, Campbell, Harry, Theodoratou, Evropi, Farrington, Susan M, Timofeeva, Maria, Dunlop, Malcolm G, Valdes, Ana M, Tikkanen, Emmi, Lehtimäki, Terho, Lyytikäinen, Leo-Pekka, Kähönen, Mika, Raitakari, Olli T, Mikkilä, Vera, Ikram, M Arfan, Sattar, Naveed, Jukema, J Wouter, Wareham, Nicholas J, Langenberg, Claudia, Forouhi, Nita G, Gundersen, Thomas E, Khaw, Kay-Tee, Butterworth, Adam S, Danesh, John, Spector, Timothy, Wang, Thomas J, Hyppönen, Elina, Kraft, Peter, and Kiel, Douglas P
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Cohort Studies ,Male ,Vesicular Transport Proteins ,Humans ,Female ,Vitamin D ,Polymorphism, Single Nucleotide ,White People ,Amidohydrolases ,Autoimmune Diseases ,Genome-Wide Association Study - Abstract
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10-9 at rs8018720 in SEC23A, and P = 1.9×10-14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.
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- 2018
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27. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
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Wain, Louise V, Verwoert, Germaine C, O'Reilly, Paul F, Shi, Gang, Johnson, Toby, Johnson, Andrew D, Bochud, Murielle, Rice, Kenneth M, Henneman, Peter, Smith, Albert V, Ehret, Georg B, Amin, Najaf, Larson, Martin G, Mooser, Vincent, Hadley, David, Dörr, Marcus, Bis, Joshua C, Aspelund, Thor, Esko, Tõnu, Janssens, A Cecile JW, Zhao, Jing Hua, Heath, Simon, Laan, Maris, Fu, Jingyuan, Pistis, Giorgio, Luan, Jian'an, Arora, Pankaj, Lucas, Gavin, Pirastu, Nicola, Pichler, Irene, Jackson, Anne U, Webster, Rebecca J, Zhang, Feng, Peden, John F, Schmidt, Helena, Tanaka, Toshiko, Campbell, Harry, Igl, Wilmar, Milaneschi, Yuri, Hottenga, Jouke-Jan, Vitart, Veronique, Chasman, Daniel I, Trompet, Stella, Bragg-Gresham, Jennifer L, Alizadeh, Behrooz Z, Chambers, John C, Guo, Xiuqing, Lehtimäki, Terho, Kühnel, Brigitte, Lopez, Lorna M, Polašek, Ozren, Boban, Mladen, Nelson, Christopher P, Morrison, Alanna C, Pihur, Vasyl, Ganesh, Santhi K, Hofman, Albert, Kundu, Suman, Mattace-Raso, Francesco US, Rivadeneira, Fernando, Sijbrands, Eric JG, Uitterlinden, Andre G, Hwang, Shih-Jen, Vasan, Ramachandran S, Wang, Thomas J, Bergmann, Sven, Vollenweider, Peter, Waeber, Gérard, Laitinen, Jaana, Pouta, Anneli, Zitting, Paavo, McArdle, Wendy L, Kroemer, Heyo K, Völker, Uwe, Völzke, Henry, Glazer, Nicole L, Taylor, Kent D, Harris, Tamara B, Alavere, Helene, Haller, Toomas, Keis, Aime, Tammesoo, Mari-Liis, Aulchenko, Yurii, Barroso, Inês, Khaw, Kay-Tee, Galan, Pilar, Hercberg, Serge, Lathrop, Mark, Eyheramendy, Susana, Org, Elin, Sõber, Siim, Lu, Xiaowen, Nolte, Ilja M, Penninx, Brenda W, Corre, Tanguy, Masciullo, Corrado, Sala, Cinzia, Groop, Leif, Voight, Benjamin F, Melander, Olle, O'Donnell, Christopher J, Salomaa, Veikko, D'Adamo, Adamo Pio, Fabretto, Antonella, Faletra, Flavio, Ulivi, Sheila, Del Greco, Fabiola M, Facheris, Maurizio, Collins, Francis S, Bergman, Richard N, Beilby, John P, Hung, Joseph, Musk, A William, Mangino, Massimo, Shin, So-Youn, Soranzo, Nicole, Watkins, Hugh, Goel, Anuj, Hamsten, Anders, Gider, Pierre, Loitfelder, Marisa, Zeginigg, Marion, Hernandez, Dena, Najjar, Samer S, Navarro, Pau, Wild, Sarah H, Corsi, Anna Maria, Singleton, Andrew, De Geus, Eco JC, Willemsen, Gonneke, Parker, Alex N, Rose, Lynda M, Buckley, Brendan, Stott, David, Orru, Marco, Uda, Manuela, LifeLines Cohort Study, Van Der Klauw, Melanie M, Zhang, Weihua, Li, Xinzhong, Scott, James, Chen, Yii-Der Ida, Burke, Gregory L, Kähönen, Mika, Viikari, Jorma, Döring, Angela, Meitinger, Thomas, Davies, Gail, Starr, John M, Emilsson, Valur, Plump, Andrew, Lindeman, Jan H, Hoen, Peter AC 'T, König, Inke R, EchoGen Consortium, Felix, Janine F, Clarke, Robert, Hopewell, Jemma C, Ongen, Halit, Breteler, Monique, Debette, Stéphanie, Destefano, Anita L, Fornage, Myriam, AortaGen Consortium, Mitchell, Gary F, CHARGE Consortium Heart Failure Working Group, Smith, Nicholas L, KidneyGen Consortium, Holm, Hilma, Stefansson, Kari, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, CKDGen Consortium, Cardiogenics Consortium, CardioGram, Samani, Nilesh J, Preuss, Michael, Rudan, Igor, Hayward, Caroline, Deary, Ian J, Wichmann, H-Erich, Raitakari, Olli T, Palmas, Walter, Kooner, Jaspal S, Stolk, Ronald P, Jukema, J Wouter, Wright, Alan F, Boomsma, Dorret I, Bandinelli, Stefania, Gyllensten, Ulf B, Wilson, James F, Ferrucci, Luigi, Schmidt, Reinhold, Farrall, Martin, Spector, Tim D, Palmer, Lyle J, Tuomilehto, Jaakko, Pfeufer, Arne, Gasparini, Paolo, Siscovick, David, Altshuler, David, Loos, Ruth JF, Toniolo, Daniela, Snieder, Harold, Gieger, Christian, Meneton, Pierre, Wareham, Nicholas J, Oostra, Ben A, Metspalu, Andres, Launer, Lenore, Rettig, Rainer, Strachan, David P, Beckmann, Jacques S, Witteman, Jacqueline CM, Erdmann, Jeanette, Van Dijk, Ko Willems, Boerwinkle, Eric, Boehnke, Michael, Ridker, Paul M, Jarvelin, Marjo-Riitta, Chakravarti, Aravinda, Abecasis, Goncalo R, Gudnason, Vilmundur, Newton-Cheh, Christopher, Levy, Daniel, Munroe, Patricia B, Psaty, Bruce M, Caulfield, Mark J, Rao, Dabeeru C, Tobin, Martin D, Elliott, Paul, and Van Duijn, Cornelia M
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Genetic Loci ,Case-Control Studies ,Hypertension ,Humans ,Blood Pressure ,cardiovascular diseases ,Arteries ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,circulatory and respiratory physiology ,Follow-Up Studies ,Genome-Wide Association Study - Abstract
Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans. We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 × 10(-8) to P = 2.3 × 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.
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- 2018
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28. Associations of autozygosity with a broad range of human phenotypes
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Clark, David W, primary, Okada, Yukinori, additional, Moore, Kristjan H S, additional, Mason, Dan, additional, Pirastu, Nicola, additional, Gandin, Ilaria, additional, Mattsson, Hannele, additional, Barnes, Catriona L K, additional, Lin, Kuang, additional, Zhao, Jing Hua, additional, Deelen, Patrick, additional, Rohde, Rebecca, additional, Schurmann, Claudia, additional, Guo, Xiuqing, additional, Giulianini, Franco, additional, Zhang, Weihua, additional, Medina-Gomez, Carolina, additional, Karlsson, Robert, additional, Bao, Yanchun, additional, Bartz, Traci M, additional, Baumbach, Clemens, additional, Biino, Ginevra, additional, Bixley, Matthew J, additional, Brumat, Marco, additional, Chai, Jin-Fang, additional, Corre, Tanguy, additional, Cousminer, Diana L, additional, Dekker, Annelot M, additional, Eccles, David A, additional, van Eijk, Kristel R, additional, Fuchsberger, Christian, additional, Gao, He, additional, Germain, Marine, additional, Gordon, Scott D, additional, de Haan, Hugoline G, additional, Harris, Sarah E, additional, Hofer, Edith, additional, Huerta-Chagoya, Alicia, additional, Igartua, Catherine, additional, Jansen, Iris E, additional, Jia, Yucheng, additional, Kacprowski, Tim, additional, Karlsson, Torgny, additional, Kleber, Marcus E, additional, Li, Shengchao Alfred, additional, Li-Gao, Ruifang, additional, Mahajan, Anubha, additional, Matsuda, Koichi, additional, Meidtner, Karina, additional, Meng, Weihua, additional, Montasser, May E, additional, van der Most, Peter J, additional, Munz, Matthias, additional, Nutile, Teresa, additional, Palviainen, Teemu, additional, Prasad, Gauri, additional, Prasad, Rashmi B, additional, Priyanka, Tallapragada Divya Sri, additional, Rizzi, Federica, additional, Salvi, Erika, additional, Sapkota, Bishwa R, additional, Shriner, Daniel, additional, Skotte, Line, additional, Smart, Melissa C, additional, Smith, Albert Vernon, additional, van der Spek, Ashley, additional, Spracklen, Cassandra N, additional, Strawbridge, Rona J, additional, Tajuddin, Salman M, additional, Trompet, Stella, additional, Turman, Constance, additional, Verweij, Niek, additional, Viberti, Clara, additional, Wang, Lihua, additional, Warren, Helen R, additional, Wootton, Robyn E, additional, Yanek, Lisa R, additional, Yao, Jie, additional, Yousri, Noha A, additional, Zhao, Wei, additional, Adeyemo, Adebowale A, additional, Afaq, Saima, additional, Aguilar-Salinas, Carlos Alberto, additional, Akiyama, Masato, additional, Albert, Matthew L, additional, Allison, Matthew A, additional, Alver, Maris, additional, Aung, Tin, additional, Azizi, Fereidoun, additional, Bentley, Amy R, additional, Boeing, Heiner, additional, Boerwinkle, Eric, additional, Borja, Judith B, additional, de Borst, Gert J, additional, Bottinger, Erwin P, additional, Broer, Linda, additional, Campbell, Harry, additional, Chanock, Stephen, additional, Chee, Miao-Li, additional, Chen, Guanjie, additional, Chen, Yii-Der I, additional, Chen, Zhengming, additional, Chiu, Yen-Feng, additional, Cocca, Massimiliano, additional, Collins, Francis S, additional, Concas, Maria Pina, additional, Corley, Janie, additional, Cugliari, Giovanni, additional, van Dam, Rob M, additional, Damulina, Anna, additional, Daneshpour, Maryam S, additional, Day, Felix R, additional, Delgado, Graciela E, additional, Dhana, Klodian, additional, Doney, Alexander S F, additional, Dörr, Marcus, additional, Doumatey, Ayo P, additional, Dzimiri, Nduna, additional, Ebenesersdóttir, S Sunna, additional, Elliott, Joshua, additional, Elliott, Paul, additional, Ewert, Ralf, additional, Felix, Janine F, additional, Fischer, Krista, additional, Freedman, Barry I, additional, Girotto, Giorgia, additional, Goel, Anuj, additional, Gögele, Martin, additional, Goodarzi, Mark O, additional, Graff, Mariaelisa, additional, Granot-Hershkovitz, Einat, additional, Grodstein, Francine, additional, Guarrera, Simonetta, additional, Gudbjartsson, Daniel F, additional, Guity, Kamran, additional, Gunnarsson, Bjarni, additional, Guo, Yu, additional, Hagenaars, Saskia P, additional, Haiman, Christopher A, additional, Halevy, Avner, additional, Harris, Tamara B, additional, Hedayati, Mehdi, additional, van Heel, David A, additional, Hirata, Makoto, additional, Höfer, Imo, additional, Hsiung, Chao Agnes, additional, Huang, Jinyan, additional, Hung, Yi-Jen, additional, Ikram, M Arfan, additional, Jagadeesan, Anuradha, additional, Jousilahti, Pekka, additional, Kamatani, Yoichiro, additional, Kanai, Masahiro, additional, Kerrison, Nicola D, additional, Kessler, Thorsten, additional, Khaw, Kay-Tee, additional, Khor, Chiea Chuen, additional, de Kleijn, Dominique P V, additional, Koh, Woon-Puay, additional, Kolcic, Ivana, additional, Kraft, Peter, additional, Krämer, Bernhard K, additional, Kutalik, Zoltán, additional, Kuusisto, Johanna, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lawlor, Deborah A, additional, Lee, I-Te, additional, Lee, Wen-Jane, additional, Lerch, Markus M, additional, Li, Liming, additional, Liu, Jianjun, additional, Loh, Marie, additional, London, Stephanie J, additional, Loomis, Stephanie, additional, Lu, Yingchang, additional, Luan, Jian’an, additional, Mägi, Reedik, additional, Manichaikul, Ani W, additional, Manunta, Paolo, additional, Másson, Gísli, additional, Matoba, Nana, additional, Mei, Xue W, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Milani, Lili, additional, Millwood, Iona Y, additional, Momozawa, Yukihide, additional, Moore, Amy, additional, Morange, Pierre-Emmanuel, additional, Moreno-Macías, Hortensia, additional, Mori, Trevor A, additional, Morrison, Alanna C, additional, Muka, Taulant, additional, Murakami, Yoshinori, additional, Murray, Alison D, additional, de Mutsert, Renée, additional, Mychaleckyj, Josyf C, additional, Nalls, Mike A, additional, Nauck, Matthias, additional, Neville, Matt J, additional, Nolte, Ilja M, additional, Ong, Ken K, additional, Orozco, Lorena, additional, Padmanabhan, Sandosh, additional, Pálsson, Gunnar, additional, Pankow, James S, additional, Pattaro, Cristian, additional, Pattie, Alison, additional, Polasek, Ozren, additional, Poulter, Neil, additional, Pramstaller, Peter P, additional, Quintana-Murci, Lluis, additional, Räikkönen, Katri, additional, Ralhan, Sarju, additional, Rao, Dabeeru C, additional, van Rheenen, Wouter, additional, Rich, Stephen S, additional, Ridker, Paul M, additional, Rietveld, Cornelius A, additional, Robino, Antonietta, additional, van Rooij, Frank J A, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sabanayagam, Charumathi, additional, Sabater-Lleal, Maria, additional, Sala, Cinzia Felicita, additional, Salomaa, Veikko, additional, Sandow, Kevin, additional, Schmidt, Helena, additional, Scott, Laura J, additional, Scott, William R, additional, Sedaghati-Khayat, Bahareh, additional, Sennblad, Bengt, additional, van Setten, Jessica, additional, Sever, Peter J, additional, Sheu, Wayne H-H, additional, Shi, Yuan, additional, Shrestha, Smeeta, additional, Shukla, Sharvari Rahul, additional, Sigurdsson, Jon K, additional, Sikka, Timo Tonis, additional, Singh, Jai Rup, additional, Smith, Blair H, additional, Stančáková, Alena, additional, Stanton, Alice, additional, Starr, John M, additional, Stefansdottir, Lilja, additional, Straker, Leon, additional, Sulem, Patrick, additional, Sveinbjornsson, Gardar, additional, Swertz, Morris A, additional, Taylor, Adele M, additional, Taylor, Kent D, additional, Terzikhan, Natalie, additional, Tham, Yih-Chung, additional, Thorleifsson, Gudmar, additional, Thorsteinsdottir, Unnur, additional, Tillander, Annika, additional, Tracy, Russell P, additional, Tusié-Luna, Teresa, additional, Tzoulaki, Ioanna, additional, Vaccargiu, Simona, additional, Vangipurapu, Jagadish, additional, Veldink, Jan H, additional, Vitart, Veronique, additional, Völker, Uwe, additional, Vuoksimaa, Eero, additional, Wakil, Salma M, additional, Waldenberger, Melanie, additional, Wander, Gurpreet S, additional, Wang, Ya Xing, additional, Wareham, Nicholas J, additional, Wild, Sarah, additional, Yajnik, Chittaranjan S, additional, Yuan, Jian-Min, additional, Zeng, Lingyao, additional, Zhang, Liang, additional, Zhou, Jie, additional, Amin, Najaf, additional, Asselbergs, Folkert W, additional, Bakker, Stephan J L, additional, Becker, Diane M, additional, Lehne, Benjamin, additional, Bennett, David A, additional, van den Berg, Leonard H, additional, Berndt, Sonja I, additional, Bharadwaj, Dwaipayan, additional, Bielak, Lawrence F, additional, Bochud, Murielle, additional, Boehnke, Mike, additional, Bouchard, Claude, additional, Bradfield, Jonathan P, additional, Brody, Jennifer A, additional, Campbell, Archie, additional, Carmi, Shai, additional, Caulfield, Mark J, additional, Cesarini, David, additional, Chambers, John C, additional, Chandak, Giriraj Ratan, additional, Cheng, Ching-Yu, additional, Ciullo, Marina, additional, Cornelis, Marilyn, additional, Cusi, Daniele, additional, Smith, George Davey, additional, Deary, Ian J, additional, Dorajoo, Rajkumar, additional, van Duijn, Cornelia M, additional, Ellinghaus, David, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Evangelou, Evangelos, additional, Evans, Michele K, additional, Faul, Jessica D, additional, Feenstra, Bjarke, additional, Feitosa, Mary, additional, Foisy, Sylvain, additional, Franke, Andre, additional, Friedlander, Yechiel, additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Gonzalez, Clicerio, additional, Goyette, Philippe, additional, Grant, Struan F A, additional, Griffiths, Lyn R, additional, Groop, Leif, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hakonarson, Hakon, additional, Hamsten, Anders, additional, van der Harst, Pim, additional, Heng, Chew-Kiat, additional, Hicks, Andrew A, additional, Hochner, Hagit, additional, Huikuri, Heikki, additional, Hunt, Steven C, additional, Jaddoe, Vincent W V, additional, De Jager, Philip L, additional, Johannesson, Magnus, additional, Johansson, Åsa, additional, Jonas, Jost B, additional, Jukema, J Wouter, additional, Junttila, Juhani, additional, Kaprio, Jaakko, additional, Kardia, Sharon L. R., additional, Karpe, Fredrik, additional, Kumari, Meena, additional, Laakso, Markku, additional, van der Laan, Sander W, additional, Lahti, Jari, additional, Laudes, Matthias, additional, Lea, Rodney A, additional, Lieb, Wolfgang, additional, Lumley, Thomas, additional, Martin, Nicholas G, additional, März, Winfried, additional, Matullo, Giuseppe, additional, McCarthy, Mark I, additional, Medland, Sarah E, additional, Merriman, Tony R, additional, Metspalu, Andres, additional, Meyer, Brian F, additional, Mohlke, Karen L, additional, Montgomery, Grant W, additional, Mook-Kanamori, Dennis, additional, Munroe, Patricia B, additional, North, Kari E, additional, Nyholt, Dale R, additional, O’connell, Jeffery R, additional, Ober, Carole, additional, Oldehinkel, Albertine J, additional, Palmas, Walter, additional, Palmer, Colin, additional, Pasterkamp, Gerard G, additional, Patin, Etienne, additional, Pennell, Craig E, additional, Perusse, Louis, additional, Peyser, Patricia A, additional, Pirastu, Mario, additional, Polderman, Tinca J. C., additional, Porteous, David J, additional, Posthuma, Danielle, additional, Psaty, Bruce M, additional, Rioux, John D, additional, Rivadeneira, Fernando, additional, Rotimi, Charles, additional, Rotter, Jerome I, additional, Rudan, Igor, additional, Den Ruijter, Hester M, additional, Sanghera, Dharambir K, additional, Sattar, Naveed, additional, Schmidt, Reinhold, additional, Schulze, Matthias B, additional, Schunkert, Heribert, additional, Scott, Robert A, additional, Shuldiner, Alan R, additional, Sim, Xueling, additional, Small, Neil, additional, Smith, Jennifer A, additional, Sotoodehnia, Nona, additional, Tai, E-Shyong, additional, Teumer, Alexander, additional, Timpson, Nicholas J, additional, Toniolo, Daniela, additional, Tregouet, David-Alexandre, additional, Tuomi, Tiinamaija, additional, Vollenweider, Peter, additional, Wang, Carol A, additional, Weir, David R, additional, Whitfield, John B, additional, Wijmenga, Cisca, additional, Wong, Tien-Yin, additional, Wright, John, additional, Yang, Jingyun, additional, Yu, Lei, additional, Zemel, Babette S, additional, Zonderman, Alan B, additional, Perola, Markus, additional, Magnusson, Patrik K. E., additional, Uitterlinden, André G, additional, Kooner, Jaspal S, additional, Chasman, Daniel I, additional, Loos, Ruth J. F., additional, Franceschini, Nora, additional, Franke, Lude, additional, Haley, Chris S, additional, Hayward, Caroline, additional, Walters, Robin G, additional, Perry, John R. B., additional, Esko, Tōnu, additional, Helgason, Agnar, additional, Stefansson, Kari, additional, Joshi, Peter K, additional, Kubo, Michiaki, additional, and Wilson, James F, additional
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- 2019
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29. Do Vitamin D Level and Dietary Calcium Intake Modify the Association Between Loop Diuretics and Bone Health?
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Oliai Araghi, Sadaf, primary, Kiefte-de Jong, Jessica C., additional, Trajanoska, Katerina, additional, Koromani, Fjorda, additional, Rivadeneira, Fernando, additional, Zillikens, M. Carola, additional, van Schoor, Natasja M., additional, de Groot, Lisette C. P. G. M., additional, Ikram, M. Arfan, additional, Uitterlinden, André G., additional, Stricker, Bruno H., additional, and van der Velde, Nathalie, additional
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- 2019
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30. Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria
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Teumer, Alexander, primary, Li, Yong, additional, Ghasemi, Sahar, additional, Prins, Bram P., additional, Wuttke, Matthias, additional, Hermle, Tobias, additional, Giri, Ayush, additional, Sieber, Karsten B., additional, Qiu, Chengxiang, additional, Kirsten, Holger, additional, Tin, Adrienne, additional, Chu, Audrey Y., additional, Bansal, Nisha, additional, Feitosa, Mary F., additional, Wang, Lihua, additional, Chai, Jin-Fang, additional, Cocca, Massimiliano, additional, Fuchsberger, Christian, additional, Gorski, Mathias, additional, Hoppmann, Anselm, additional, Horn, Katrin, additional, Li, Man, additional, Marten, Jonathan, additional, Noce, Damia, additional, Nutile, Teresa, additional, Sedaghat, Sanaz, additional, Sveinbjornsson, Gardar, additional, Tayo, Bamidele O., additional, van der Most, Peter J., additional, Xu, Yizhe, additional, Yu, Zhi, additional, Gerstner, Lea, additional, Ärnlöv, Johan, additional, Bakker, Stephan J. L., additional, Baptista, Daniela, additional, Biggs, Mary L., additional, Boerwinkle, Eric, additional, Brenner, Hermann, additional, Burkhardt, Ralph, additional, Carroll, Robert J., additional, Chee, Miao-Li, additional, Chee, Miao-Ling, additional, Chen, Mengmeng, additional, Cheng, Ching-Yu, additional, Cook, James P., additional, Coresh, Josef, additional, Corre, Tanguy, additional, Danesh, John, additional, de Borst, Martin H., additional, De Grandi, Alessandro, additional, de Mutsert, Renée, additional, de Vries, Aiko P. J., additional, Degenhardt, Frauke, additional, Dittrich, Katalin, additional, Divers, Jasmin, additional, Eckardt, Kai-Uwe, additional, Ehret, Georg, additional, Endlich, Karlhans, additional, Felix, Janine F., additional, Franco, Oscar H., additional, Franke, Andre, additional, Freedman, Barry I., additional, Freitag-Wolf, Sandra, additional, Gansevoort, Ron T., additional, Giedraitis, Vilmantas, additional, Gögele, Martin, additional, Grundner-Culemann, Franziska, additional, Gudbjartsson, Daniel F., additional, Gudnason, Vilmundur, additional, Hamet, Pavel, additional, Harris, Tamara B., additional, Hicks, Andrew A., additional, Holm, Hilma, additional, Foo, Valencia Hui Xian, additional, Hwang, Shih-Jen, additional, Ikram, M. Arfan, additional, Ingelsson, Erik, additional, Jaddoe, Vincent W. V., additional, Jakobsdottir, Johanna, additional, Josyula, Navya Shilpa, additional, Jung, Bettina, additional, Kähönen, Mika, additional, Khor, Chiea-Chuen, additional, Kiess, Wieland, additional, Koenig, Wolfgang, additional, Körner, Antje, additional, Kovacs, Peter, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kronenberg, Florian, additional, Lange, Leslie A., additional, Langefeld, Carl D., additional, Lee, Jeannette Jen-Mai, additional, Lehtimäki, Terho, additional, Lieb, Wolfgang, additional, Lim, Su-Chi, additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Liu, Jianjun, additional, Loeffler, Markus, additional, Lyytikäinen, Leo-Pekka, additional, Mahajan, Anubha, additional, Maranville, Joseph C., additional, Mascalzoni, Deborah, additional, McMullen, Barbara, additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Miliku, Kozeta, additional, Mook-Kanamori, Dennis O., additional, Müller-Nurasyid, Martina, additional, Mychaleckyj, Josyf C., additional, Nauck, Matthias, additional, Nikus, Kjell, additional, Ning, Boting, additional, Noordam, Raymond, additional, Connell, Jeffrey O’, additional, Olafsson, Isleifur, additional, Palmer, Nicholette D., additional, Peters, Annette, additional, Podgornaia, Anna I., additional, Ponte, Belen, additional, Poulain, Tanja, additional, Pramstaller, Peter P., additional, Rabelink, Ton J., additional, Raffield, Laura M., additional, Reilly, Dermot F., additional, Rettig, Rainer, additional, Rheinberger, Myriam, additional, Rice, Kenneth M., additional, Rivadeneira, Fernando, additional, Runz, Heiko, additional, Ryan, Kathleen A., additional, Sabanayagam, Charumathi, additional, Saum, Kai-Uwe, additional, Schöttker, Ben, additional, Shaffer, Christian M., additional, Shi, Yuan, additional, Smith, Albert V., additional, Strauch, Konstantin, additional, Stumvoll, Michael, additional, Sun, Benjamin B., additional, Szymczak, Silke, additional, Tai, E-Shyong, additional, Tan, Nicholas Y. Q., additional, Taylor, Kent D., additional, Teren, Andrej, additional, Tham, Yih-Chung, additional, Thiery, Joachim, additional, Thio, Chris H. L., additional, Thomsen, Hauke, additional, Thorsteinsdottir, Unnur, additional, Tönjes, Anke, additional, Tremblay, Johanne, additional, Uitterlinden, André G., additional, van der Harst, Pim, additional, Verweij, Niek, additional, Vogelezang, Suzanne, additional, Völker, Uwe, additional, Waldenberger, Melanie, additional, Wang, Chaolong, additional, Wilson, Otis D., additional, Wong, Charlene, additional, Wong, Tien-Yin, additional, Yang, Qiong, additional, Yasuda, Masayuki, additional, Akilesh, Shreeram, additional, Bochud, Murielle, additional, Böger, Carsten A., additional, Devuyst, Olivier, additional, Edwards, Todd L., additional, Ho, Kevin, additional, Morris, Andrew P., additional, Parsa, Afshin, additional, Pendergrass, Sarah A., additional, Psaty, Bruce M., additional, Rotter, Jerome I., additional, Stefansson, Kari, additional, Wilson, James G., additional, Susztak, Katalin, additional, Snieder, Harold, additional, Heid, Iris M., additional, Scholz, Markus, additional, Butterworth, Adam S., additional, Hung, Adriana M., additional, Pattaro, Cristian, additional, and Köttgen, Anna, additional
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- 2019
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31. Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration
- Author
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Liu, Xueping, primary, Helenius, Dorte, additional, Skotte, Line, additional, Beaumont, Robin N., additional, Wielscher, Matthias, additional, Geller, Frank, additional, Juodakis, Julius, additional, Mahajan, Anubha, additional, Bradfield, Jonathan P., additional, Lin, Frederick T. J., additional, Vogelezang, Suzanne, additional, Bustamante, Mariona, additional, Ahluwalia, Tarunveer S., additional, Pitkänen, Niina, additional, Wang, Carol A., additional, Bacelis, Jonas, additional, Borges, Maria C., additional, Zhang, Ge, additional, Bedell, Bruce A., additional, Rossi, Robert M., additional, Skogstrand, Kristin, additional, Peng, Shouneng, additional, Thompson, Wesley K., additional, Appadurai, Vivek, additional, Lawlor, Debbie A., additional, Kalliala, Ilkka, additional, Power, Christine, additional, McCarthy, Mark I., additional, Boyd, Heather A., additional, Marazita, Mary L., additional, Hakonarson, Hakon, additional, Hayes, M. Geoffrey, additional, Scholtens, Denise M., additional, Rivadeneira, Fernando, additional, Jaddoe, Vincent W. V., additional, Vinding, Rebecca K., additional, Bisgaard, Hans, additional, Knight, Bridget A., additional, Pahkala, Katja, additional, Raitakari, Olli, additional, Helgeland, Øyvind, additional, Johansson, Stefan, additional, Njølstad, Pål R., additional, Fadista, João, additional, Schork, Andrew J., additional, Nudel, Ron, additional, Miller, Daniel E., additional, Chen, Xiaoting, additional, Weirauch, Matthew T., additional, Mortensen, Preben Bo, additional, Børglum, Anders D., additional, Nordentoft, Merete, additional, Mors, Ole, additional, Hao, Ke, additional, Ryckman, Kelli K., additional, Hougaard, David M., additional, Kottyan, Leah C., additional, Pennell, Craig E., additional, Lyytikainen, Leo-Pekka, additional, Bønnelykke, Klaus, additional, Vrijheid, Martine, additional, Felix, Janine F., additional, Lowe, William L., additional, Grant, Struan F. A., additional, Hyppönen, Elina, additional, Jacobsson, Bo, additional, Jarvelin, Marjo-Riitta, additional, Muglia, Louis J., additional, Murray, Jeffrey C., additional, Freathy, Rachel M., additional, Werge, Thomas M., additional, Melbye, Mads, additional, Buil, Alfonso, additional, and Feenstra, Bjarke, additional
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- 2019
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32. Novel metabolic indices and incident type 2 diabetes among women and men: the Rotterdam Study
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Brahimaj, Adela, primary, Rivadeneira, Fernando, additional, Muka, Taulant, additional, Sijbrands, Eric J. G., additional, Franco, Oscar H., additional, Dehghan, Abbas, additional, and Kavousi, Maryam, additional
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- 2019
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33. Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
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Styrkarsdottir, Unnur, primary, Stefansson, Olafur A., additional, Gunnarsdottir, Kristbjorg, additional, Thorleifsson, Gudmar, additional, Lund, Sigrun H., additional, Stefansdottir, Lilja, additional, Juliusson, Kristinn, additional, Agustsdottir, Arna B., additional, Zink, Florian, additional, Halldorsson, Gisli H., additional, Ivarsdottir, Erna V., additional, Benonisdottir, Stefania, additional, Jonsson, Hakon, additional, Gylfason, Arnaldur, additional, Norland, Kristjan, additional, Trajanoska, Katerina, additional, Boer, Cindy G., additional, Southam, Lorraine, additional, Leung, Jason C. S., additional, Tang, Nelson L. S., additional, Kwok, Timothy C. Y., additional, Lee, Jenny S. W., additional, Ho, Suzanne C., additional, Byrjalsen, Inger, additional, Center, Jacqueline R., additional, Lee, Seung Hun, additional, Koh, Jung-Min, additional, Lohmander, L. Stefan, additional, Ho-Pham, Lan T., additional, Nguyen, Tuan V., additional, Eisman, John A., additional, Woo, Jean, additional, Leung, Ping-C., additional, Loughlin, John, additional, Zeggini, Eleftheria, additional, Christiansen, Claus, additional, Rivadeneira, Fernando, additional, van Meurs, Joyce, additional, Uitterlinden, Andre G., additional, Mogensen, Brynjolfur, additional, Jonsson, Helgi, additional, Ingvarsson, Thorvaldur, additional, Sigurdsson, Gunnar, additional, Benediktsson, Rafn, additional, Sulem, Patrick, additional, Jonsdottir, Ingileif, additional, Masson, Gisli, additional, Holm, Hilma, additional, Norddahl, Gudmundur L., additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F., additional, and Stefansson, Kari, additional
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- 2019
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34. GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures
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Styrkarsdottir, Unnur, primary, Stefansson, Olafur A., additional, Gunnarsdottir, Kristbjorg, additional, Thorleifsson, Gudmar, additional, Lund, Sigrun H., additional, Stefansdottir, Lilja, additional, Juliusson, Kristinn, additional, Agustsdottir, Arna B., additional, Zink, Florian, additional, Halldorsson, Gisli H., additional, Ivarsdottir, Erna V., additional, Benonisdottir, Stefania, additional, Jonsson, Hakon, additional, Gylfason, Arnaldur, additional, Norland, Kristjan, additional, Trajanoska, Katerina, additional, Boer, Cindy G., additional, Southam, Lorraine, additional, Leung, Jason C. S., additional, Tang, Nelson L. S., additional, Kwok, Timothy C. Y., additional, Lee, Jenny S. W., additional, Ho, Suzanne C., additional, Byrjalsen, Inger, additional, Center, Jacqueline R., additional, Lee, Seung Hun, additional, Koh, Jung-Min, additional, Lohmander, L. Stefan, additional, Ho-Pham, Lan T., additional, Nguyen, Tuan V., additional, Eisman, John A., additional, Woo, Jean, additional, Leung, Ping-C., additional, Loughlin, John, additional, Zeggini, Eleftheria, additional, Christiansen, Claus, additional, Rivadeneira, Fernando, additional, van Meurs, Joyce, additional, Uitterlinden, Andre G., additional, Mogensen, Brynjolfur, additional, Jonsson, Helgi, additional, Ingvarsson, Thorvaldur, additional, Sigurdsson, Gunnar, additional, Benediktsson, Rafn, additional, Sulem, Patrick, additional, Jonsdottir, Ingileif, additional, Masson, Gisli, additional, Holm, Hilma, additional, Norddahl, Gudmundur L., additional, Thorsteinsdottir, Unnur, additional, Gudbjartsson, Daniel F., additional, and Stefansson, Kari, additional
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- 2019
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35. Genetics of Bone and Muscle Interactions in Humans
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Trajanoska, Katerina, primary, Rivadeneira, Fernando, additional, Kiel, Douglas P., additional, and Karasik, David, additional
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- 2019
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36. Using Mendelian Randomization to Decipher Mechanisms of Bone Disease
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Trajanoska, Katerina, primary and Rivadeneira, Fernando, additional
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- 2018
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37. Genome-wide Analysis of Large-scale Longitudinal Outcomes using Penalization —GALLOP algorithm
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Sikorska, Karolina, primary, Lesaffre, Emmanuel, additional, Groenen, Patrick J. F., additional, Rivadeneira, Fernando, additional, and Eilers, Paul H. C., additional
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- 2018
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38. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
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Jiang, Xia, primary, O’Reilly, Paul F., additional, Aschard, Hugues, additional, Hsu, Yi-Hsiang, additional, Richards, J. Brent, additional, Dupuis, Josée, additional, Ingelsson, Erik, additional, Karasik, David, additional, Pilz, Stefan, additional, Berry, Diane, additional, Kestenbaum, Bryan, additional, Zheng, Jusheng, additional, Luan, Jianan, additional, Sofianopoulou, Eleni, additional, Streeten, Elizabeth A., additional, Albanes, Demetrius, additional, Lutsey, Pamela L., additional, Yao, Lu, additional, Tang, Weihong, additional, Econs, Michael J., additional, Wallaschofski, Henri, additional, Völzke, Henry, additional, Zhou, Ang, additional, Power, Chris, additional, McCarthy, Mark I., additional, Michos, Erin D., additional, Boerwinkle, Eric, additional, Weinstein, Stephanie J., additional, Freedman, Neal D., additional, Huang, Wen-Yi, additional, Van Schoor, Natasja M., additional, van der Velde, Nathalie, additional, Groot, Lisette C. P. G. M. de, additional, Enneman, Anke, additional, Cupples, L. Adrienne, additional, Booth, Sarah L., additional, Vasan, Ramachandran S., additional, Liu, Ching-Ti, additional, Zhou, Yanhua, additional, Ripatti, Samuli, additional, Ohlsson, Claes, additional, Vandenput, Liesbeth, additional, Lorentzon, Mattias, additional, Eriksson, Johan G., additional, Shea, M. Kyla, additional, Houston, Denise K., additional, Kritchevsky, Stephen B., additional, Liu, Yongmei, additional, Lohman, Kurt K., additional, Ferrucci, Luigi, additional, Peacock, Munro, additional, Gieger, Christian, additional, Beekman, Marian, additional, Slagboom, Eline, additional, Deelen, Joris, additional, Heemst, Diana van, additional, Kleber, Marcus E., additional, März, Winfried, additional, de Boer, Ian H., additional, Wood, Alexis C., additional, Rotter, Jerome I., additional, Rich, Stephen S., additional, Robinson-Cohen, Cassianne, additional, den Heijer, Martin, additional, Jarvelin, Marjo-Riitta, additional, Cavadino, Alana, additional, Joshi, Peter K., additional, Wilson, James F., additional, Hayward, Caroline, additional, Lind, Lars, additional, Michaëlsson, Karl, additional, Trompet, Stella, additional, Zillikens, M. Carola, additional, Uitterlinden, Andre G., additional, Rivadeneira, Fernando, additional, Broer, Linda, additional, Zgaga, Lina, additional, Campbell, Harry, additional, Theodoratou, Evropi, additional, Farrington, Susan M., additional, Timofeeva, Maria, additional, Dunlop, Malcolm G., additional, Valdes, Ana M., additional, Tikkanen, Emmi, additional, Lehtimäki, Terho, additional, Lyytikäinen, Leo-Pekka, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, Mikkilä, Vera, additional, Ikram, M. Arfan, additional, Sattar, Naveed, additional, Jukema, J. Wouter, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Forouhi, Nita G., additional, Gundersen, Thomas E., additional, Khaw, Kay-Tee, additional, Butterworth, Adam S., additional, Danesh, John, additional, Spector, Timothy, additional, Wang, Thomas J., additional, Hyppönen, Elina, additional, Kraft, Peter, additional, and Kiel, Douglas P., additional
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- 2018
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39. Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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Zillikens, M. Carola, primary, Demissie, Serkalem, additional, Hsu, Yi-Hsiang, additional, Yerges-Armstrong, Laura M., additional, Chou, Wen-Chi, additional, Stolk, Lisette, additional, Livshits, Gregory, additional, Broer, Linda, additional, Johnson, Toby, additional, Koller, Daniel L., additional, Kutalik, Zoltán, additional, Luan, Jian’an, additional, Malkin, Ida, additional, Ried, Janina S., additional, Smith, Albert V., additional, Thorleifsson, Gudmar, additional, Vandenput, Liesbeth, additional, Hua Zhao, Jing, additional, Zhang, Weihua, additional, Aghdassi, Ali, additional, Åkesson, Kristina, additional, Amin, Najaf, additional, Baier, Leslie J., additional, Barroso, Inês, additional, Bennett, David A., additional, Bertram, Lars, additional, Biffar, Rainer, additional, Bochud, Murielle, additional, Boehnke, Michael, additional, Borecki, Ingrid B., additional, Buchman, Aron S., additional, Byberg, Liisa, additional, Campbell, Harry, additional, Campos Obanda, Natalia, additional, Cauley, Jane A., additional, Cawthon, Peggy M., additional, Cederberg, Henna, additional, Chen, Zhao, additional, Cho, Nam H., additional, Jin Choi, Hyung, additional, Claussnitzer, Melina, additional, Collins, Francis, additional, Cummings, Steven R., additional, De Jager, Philip L., additional, Demuth, Ilja, additional, Dhonukshe-Rutten, Rosalie A. M., additional, Diatchenko, Luda, additional, Eiriksdottir, Gudny, additional, Enneman, Anke W., additional, Erdos, Mike, additional, Eriksson, Johan G., additional, Eriksson, Joel, additional, Estrada, Karol, additional, Evans, Daniel S., additional, Feitosa, Mary F., additional, Fu, Mao, additional, Garcia, Melissa, additional, Gieger, Christian, additional, Girke, Thomas, additional, Glazer, Nicole L., additional, Grallert, Harald, additional, Grewal, Jagvir, additional, Han, Bok-Ghee, additional, Hanson, Robert L., additional, Hayward, Caroline, additional, Hofman, Albert, additional, Hoffman, Eric P., additional, Homuth, Georg, additional, Hsueh, Wen-Chi, additional, Hubal, Monica J., additional, Hubbard, Alan, additional, Huffman, Kim M., additional, Husted, Lise B., additional, Illig, Thomas, additional, Ingelsson, Erik, additional, Ittermann, Till, additional, Jansson, John-Olov, additional, Jordan, Joanne M., additional, Jula, Antti, additional, Karlsson, Magnus, additional, Khaw, Kay-Tee, additional, Kilpeläinen, Tuomas O., additional, Klopp, Norman, additional, Kloth, Jacqueline S. L., additional, Koistinen, Heikki A., additional, Kraus, William E., additional, Kritchevsky, Stephen, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lang, Thomas, additional, Langdahl, Bente L., additional, Launer, Lenore J., additional, Lee, Jong-Young, additional, Lerch, Markus M., additional, Lewis, Joshua R., additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Yongmei, additional, Liu, Tian, additional, Liu, Youfang, additional, Ljunggren, Östen, additional, Lorentzon, Mattias, additional, Luben, Robert N., additional, Maixner, William, additional, McGuigan, Fiona E., additional, Medina-Gomez, Carolina, additional, Meitinger, Thomas, additional, Melhus, Håkan, additional, Mellström, Dan, additional, Melov, Simon, additional, Michaëlsson, Karl, additional, Mitchell, Braxton D., additional, Morris, Andrew P., additional, Mosekilde, Leif, additional, Newman, Anne, additional, Nielson, Carrie M., additional, O’Connell, Jeffrey R., additional, Oostra, Ben A., additional, Orwoll, Eric S., additional, Palotie, Aarno, additional, Parker, Stephen C. J., additional, Peacock, Munro, additional, Perola, Markus, additional, Peters, Annette, additional, Polasek, Ozren, additional, Prince, Richard L., additional, Räikkönen, Katri, additional, Ralston, Stuart H., additional, Ripatti, Samuli, additional, Robbins, John A., additional, Rotter, Jerome I., additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Satterfield, Suzanne, additional, Schadt, Eric E., additional, Schipf, Sabine, additional, Scott, Laura, additional, Sehmi, Joban, additional, Shen, Jian, additional, Soo Shin, Chan, additional, Sigurdsson, Gunnar, additional, Smith, Shad, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Steinhagen-Thiessen, Elisabeth, additional, Streeten, Elizabeth A., additional, Styrkarsdottir, Unnur, additional, Swart, Karin M. A., additional, Tan, Sian-Tsung, additional, Tarnopolsky, Mark A., additional, Thompson, Patricia, additional, Thomson, Cynthia A., additional, Thorsteinsdottir, Unnur, additional, Tikkanen, Emmi, additional, Tranah, Gregory J., additional, Tuomilehto, Jaakko, additional, van Schoor, Natasja M., additional, Verma, Arjun, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Wactawski-Wende, Jean, additional, Walker, Mark, additional, Weedon, Michael N., additional, Welch, Ryan, additional, Wichmann, H.-Erich, additional, Widen, Elisabeth, additional, Williams, Frances M. K., additional, Wilson, James F., additional, Wright, Nicole C., additional, Xie, Weijia, additional, Yu, Lei, additional, Zhou, Yanhua, additional, Chambers, John C., additional, Döring, Angela, additional, van Duijn, Cornelia M., additional, Econs, Michael J., additional, Gudnason, Vilmundur, additional, Kooner, Jaspal S., additional, Psaty, Bruce M., additional, Spector, Timothy D., additional, Stefansson, Kari, additional, Rivadeneira, Fernando, additional, Uitterlinden, André G., additional, Wareham, Nicholas J., additional, Ossowski, Vicky, additional, Waterworth, Dawn, additional, Loos, Ruth J. F., additional, Karasik, David, additional, Harris, Tamara B., additional, Ohlsson, Claes, additional, and Kiel, Douglas P., additional
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- 2017
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40. Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity
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Joshi, Peter K., primary, Pirastu, Nicola, additional, Kentistou, Katherine A., additional, Fischer, Krista, additional, Hofer, Edith, additional, Schraut, Katharina E., additional, Clark, David W., additional, Nutile, Teresa, additional, Barnes, Catriona L. K., additional, Timmers, Paul R. H. J., additional, Shen, Xia, additional, Gandin, Ilaria, additional, McDaid, Aaron F., additional, Hansen, Thomas Folkmann, additional, Gordon, Scott D., additional, Giulianini, Franco, additional, Boutin, Thibaud S., additional, Abdellaoui, Abdel, additional, Zhao, Wei, additional, Medina-Gomez, Carolina, additional, Bartz, Traci M., additional, Trompet, Stella, additional, Lange, Leslie A., additional, Raffield, Laura, additional, van der Spek, Ashley, additional, Galesloot, Tessel E., additional, Proitsi, Petroula, additional, Yanek, Lisa R., additional, Bielak, Lawrence F., additional, Payton, Antony, additional, Murgia, Federico, additional, Concas, Maria Pina, additional, Biino, Ginevra, additional, Tajuddin, Salman M., additional, Seppälä, Ilkka, additional, Amin, Najaf, additional, Boerwinkle, Eric, additional, Børglum, Anders D., additional, Campbell, Archie, additional, Demerath, Ellen W., additional, Demuth, Ilja, additional, Faul, Jessica D., additional, Ford, Ian, additional, Gialluisi, Alessandro, additional, Gögele, Martin, additional, Graff, MariaElisa, additional, Hingorani, Aroon, additional, Hottenga, Jouke-Jan, additional, Hougaard, David M., additional, Hurme, Mikko A., additional, Ikram, M. Arfan, additional, Jylhä, Marja, additional, Kuh, Diana, additional, Ligthart, Lannie, additional, Lill, Christina M., additional, Lindenberger, Ulman, additional, Lumley, Thomas, additional, Mägi, Reedik, additional, Marques-Vidal, Pedro, additional, Medland, Sarah E., additional, Milani, Lili, additional, Nagy, Reka, additional, Ollier, William E. R., additional, Peyser, Patricia A., additional, Pramstaller, Peter P., additional, Ridker, Paul M., additional, Rivadeneira, Fernando, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Slagboom, P. Eline, additional, Smith, Blair H., additional, Smith, Jennifer A., additional, Sotoodehnia, Nona, additional, Steinhagen-Thiessen, Elisabeth, additional, van Rooij, Frank J. A., additional, Verbeek, André L., additional, Vermeulen, Sita H., additional, Vollenweider, Peter, additional, Wang, Yunpeng, additional, Werge, Thomas, additional, Whitfield, John B., additional, Zonderman, Alan B., additional, Lehtimäki, Terho, additional, Evans, Michele K., additional, Pirastu, Mario, additional, Fuchsberger, Christian, additional, Bertram, Lars, additional, Pendleton, Neil, additional, Kardia, Sharon L. R., additional, Ciullo, Marina, additional, Becker, Diane M., additional, Wong, Andrew, additional, Psaty, Bruce M., additional, van Duijn, Cornelia M., additional, Wilson, James G., additional, Jukema, J. Wouter, additional, Kiemeney, Lambertus, additional, Uitterlinden, André G., additional, Franceschini, Nora, additional, North, Kari E., additional, Weir, David R., additional, Metspalu, Andres, additional, Boomsma, Dorret I., additional, Hayward, Caroline, additional, Chasman, Daniel, additional, Martin, Nicholas G., additional, Sattar, Naveed, additional, Campbell, Harry, additional, Esko, Tōnu, additional, Kutalik, Zoltán, additional, and Wilson, James F., additional
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- 2017
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41. CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits
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Macé, Aurélien, primary, Tuke, Marcus A., additional, Deelen, Patrick, additional, Kristiansson, Kati, additional, Mattsson, Hannele, additional, Nõukas, Margit, additional, Sapkota, Yadav, additional, Schick, Ursula, additional, Porcu, Eleonora, additional, Rüeger, Sina, additional, McDaid, Aaron F., additional, Porteous, David, additional, Winkler, Thomas W., additional, Salvi, Erika, additional, Shrine, Nick, additional, Liu, Xueping, additional, Ang, Wei Q., additional, Zhang, Weihua, additional, Feitosa, Mary F., additional, Venturini, Cristina, additional, van der Most, Peter J., additional, Rosengren, Anders, additional, Wood, Andrew R., additional, Beaumont, Robin N., additional, Jones, Samuel E., additional, Ruth, Katherine S., additional, Yaghootkar, Hanieh, additional, Tyrrell, Jessica, additional, Havulinna, Aki S., additional, Boers, Harmen, additional, Mägi, Reedik, additional, Kriebel, Jennifer, additional, Müller-Nurasyid, Martina, additional, Perola, Markus, additional, Nieminen, Markku, additional, Lokki, Marja-Liisa, additional, Kähönen, Mika, additional, Viikari, Jorma S., additional, Geller, Frank, additional, Lahti, Jari, additional, Palotie, Aarno, additional, Koponen, Päivikki, additional, Lundqvist, Annamari, additional, Rissanen, Harri, additional, Bottinger, Erwin P., additional, Afaq, Saima, additional, Wojczynski, Mary K., additional, Lenzini, Petra, additional, Nolte, Ilja M., additional, Sparsø, Thomas, additional, Schupf, Nicole, additional, Christensen, Kaare, additional, Perls, Thomas T., additional, Newman, Anne B., additional, Werge, Thomas, additional, Snieder, Harold, additional, Spector, Timothy D., additional, Chambers, John C., additional, Koskinen, Seppo, additional, Melbye, Mads, additional, Raitakari, Olli T., additional, Lehtimäki, Terho, additional, Tobin, Martin D., additional, Wain, Louise V., additional, Sinisalo, Juha, additional, Peters, Annette, additional, Meitinger, Thomas, additional, Martin, Nicholas G., additional, Wray, Naomi R., additional, Montgomery, Grant W., additional, Medland, Sarah E., additional, Swertz, Morris A., additional, Vartiainen, Erkki, additional, Borodulin, Katja, additional, Männistö, Satu, additional, Murray, Anna, additional, Bochud, Murielle, additional, Jacquemont, Sébastien, additional, Rivadeneira, Fernando, additional, Hansen, Thomas F., additional, Oldehinkel, Albertine J., additional, Mangino, Massimo, additional, Province, Michael A., additional, Deloukas, Panos, additional, Kooner, Jaspal S., additional, Freathy, Rachel M., additional, Pennell, Craig, additional, Feenstra, Bjarke, additional, Strachan, David P., additional, Lettre, Guillaume, additional, Hirschhorn, Joel, additional, Cusi, Daniele, additional, Heid, Iris M., additional, Hayward, Caroline, additional, Männik, Katrin, additional, Beckmann, Jacques S., additional, Loos, Ruth J. F., additional, Nyholt, Dale R., additional, Metspalu, Andres, additional, Eriksson, Johan G., additional, Weedon, Michael N., additional, Salomaa, Veikko, additional, Franke, Lude, additional, Reymond, Alexandre, additional, Frayling, Timothy M., additional, and Kutalik, Zoltán, additional
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- 2017
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42. Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
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Kemp, John P, primary, Morris, John A, additional, Medina-Gomez, Carolina, additional, Forgetta, Vincenzo, additional, Warrington, Nicole M, additional, Youlten, Scott E, additional, Zheng, Jie, additional, Gregson, Celia L, additional, Grundberg, Elin, additional, Trajanoska, Katerina, additional, Logan, John G, additional, Pollard, Andrea S, additional, Sparkes, Penny C, additional, Ghirardello, Elena J, additional, Allen, Rebecca, additional, Leitch, Victoria D, additional, Butterfield, Natalie C, additional, Komla-Ebri, Davide, additional, Adoum, Anne-Tounsia, additional, Curry, Katharine F, additional, White, Jacqueline K, additional, Kussy, Fiona, additional, Greenlaw, Keelin M, additional, Xu, Changjiang, additional, Harvey, Nicholas C, additional, Cooper, Cyrus, additional, Adams, David J, additional, Greenwood, Celia M T, additional, Maurano, Matthew T, additional, Kaptoge, Stephen, additional, Rivadeneira, Fernando, additional, Tobias, Jonathan H, additional, Croucher, Peter I, additional, Ackert-Bicknell, Cheryl L, additional, Bassett, J H Duncan, additional, Williams, Graham R, additional, Richards, J Brent, additional, and Evans, David M, additional
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- 2017
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43. Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus
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Medina-Gomez, Carolina, primary, Kemp, John P., additional, Dimou, Niki L., additional, Kreiner, Eskil, additional, Chesi, Alessandra, additional, Zemel, Babette S., additional, Bønnelykke, Klaus, additional, Boer, Cindy G., additional, Ahluwalia, Tarunveer S., additional, Bisgaard, Hans, additional, Evangelou, Evangelos, additional, Heppe, Denise H. M., additional, Bonewald, Lynda F., additional, Gorski, Jeffrey P., additional, Ghanbari, Mohsen, additional, Demissie, Serkalem, additional, Duque, Gustavo, additional, Maurano, Matthew T., additional, Kiel, Douglas P., additional, Hsu, Yi-Hsiang, additional, C.J. van der Eerden, Bram, additional, Ackert-Bicknell, Cheryl, additional, Reppe, Sjur, additional, Gautvik, Kaare M., additional, Raastad, Truls, additional, Karasik, David, additional, van de Peppel, Jeroen, additional, Jaddoe, Vincent W. V., additional, Uitterlinden, André G., additional, Tobias, Jonathan H., additional, Grant, Struan F.A., additional, Bagos, Pantelis G., additional, Evans, David M., additional, and Rivadeneira, Fernando, additional
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- 2017
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44. Dietary patterns and changes in frailty status: the Rotterdam study
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de Haas, Sandra C. M., primary, de Jonge, Ester A. L., additional, Voortman, Trudy, additional, Graaff, Jolien Steenweg-de, additional, Franco, Oscar H., additional, Ikram, M. Arfan, additional, Rivadeneira, Fernando, additional, Kiefte-de Jong, Jessica C., additional, and Schoufour, Josje D., additional
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- 2017
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45. Population-specific genetic variation in large sequencing data sets: why more data is still better
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van Rooij, Jeroen G J, primary, Jhamai, Mila, additional, Arp, Pascal P, additional, Nouwens, Stephan C A, additional, Verkerk, Marijn, additional, Hofman, Albert, additional, Ikram, M Arfan, additional, Verkerk, Annemieke J, additional, van Meurs, Joyce B J, additional, Rivadeneira, Fernando, additional, Uitterlinden, André G, additional, and Kraaij, Robert, additional
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- 2017
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46. Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
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Zillikens, M. Carola, primary, Demissie, Serkalem, additional, Hsu, Yi-Hsiang, additional, Yerges-Armstrong, Laura M., additional, Chou, Wen-Chi, additional, Stolk, Lisette, additional, Livshits, Gregory, additional, Broer, Linda, additional, Johnson, Toby, additional, Koller, Daniel L., additional, Kutalik, Zoltán, additional, Luan, Jian’an, additional, Malkin, Ida, additional, Ried, Janina S., additional, Smith, Albert V., additional, Thorleifsson, Gudmar, additional, Vandenput, Liesbeth, additional, Hua Zhao, Jing, additional, Zhang, Weihua, additional, Aghdassi, Ali, additional, Åkesson, Kristina, additional, Amin, Najaf, additional, Baier, Leslie J., additional, Barroso, Inês, additional, Bennett, David A., additional, Bertram, Lars, additional, Biffar, Rainer, additional, Bochud, Murielle, additional, Boehnke, Michael, additional, Borecki, Ingrid B., additional, Buchman, Aron S., additional, Byberg, Liisa, additional, Campbell, Harry, additional, Campos Obanda, Natalia, additional, Cauley, Jane A., additional, Cawthon, Peggy M., additional, Cederberg, Henna, additional, Chen, Zhao, additional, Cho, Nam H., additional, Jin Choi, Hyung, additional, Claussnitzer, Melina, additional, Collins, Francis, additional, Cummings, Steven R., additional, De Jager, Philip L., additional, Demuth, Ilja, additional, Dhonukshe-Rutten, Rosalie A. M., additional, Diatchenko, Luda, additional, Eiriksdottir, Gudny, additional, Enneman, Anke W., additional, Erdos, Mike, additional, Eriksson, Johan G., additional, Eriksson, Joel, additional, Estrada, Karol, additional, Evans, Daniel S., additional, Feitosa, Mary F., additional, Fu, Mao, additional, Garcia, Melissa, additional, Gieger, Christian, additional, Girke, Thomas, additional, Glazer, Nicole L., additional, Grallert, Harald, additional, Grewal, Jagvir, additional, Han, Bok-Ghee, additional, Hanson, Robert L., additional, Hayward, Caroline, additional, Hofman, Albert, additional, Hoffman, Eric P., additional, Homuth, Georg, additional, Hsueh, Wen-Chi, additional, Hubal, Monica J., additional, Hubbard, Alan, additional, Huffman, Kim M., additional, Husted, Lise B., additional, Illig, Thomas, additional, Ingelsson, Erik, additional, Ittermann, Till, additional, Jansson, John-Olov, additional, Jordan, Joanne M., additional, Jula, Antti, additional, Karlsson, Magnus, additional, Khaw, Kay-Tee, additional, Kilpeläinen, Tuomas O., additional, Klopp, Norman, additional, Kloth, Jacqueline S. L., additional, Koistinen, Heikki A., additional, Kraus, William E., additional, Kritchevsky, Stephen, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lahti, Jari, additional, Lang, Thomas, additional, Langdahl, Bente L., additional, Launer, Lenore J., additional, Lee, Jong-Young, additional, Lerch, Markus M., additional, Lewis, Joshua R., additional, Lind, Lars, additional, Lindgren, Cecilia, additional, Liu, Yongmei, additional, Liu, Tian, additional, Liu, Youfang, additional, Ljunggren, Östen, additional, Lorentzon, Mattias, additional, Luben, Robert N., additional, Maixner, William, additional, McGuigan, Fiona E., additional, Medina-Gomez, Carolina, additional, Meitinger, Thomas, additional, Melhus, Håkan, additional, Mellström, Dan, additional, Melov, Simon, additional, Michaëlsson, Karl, additional, Mitchell, Braxton D., additional, Morris, Andrew P., additional, Mosekilde, Leif, additional, Newman, Anne, additional, Nielson, Carrie M., additional, O’Connell, Jeffrey R., additional, Oostra, Ben A., additional, Orwoll, Eric S., additional, Palotie, Aarno, additional, Parker, Stephen C. J., additional, Peacock, Munro, additional, Perola, Markus, additional, Peters, Annette, additional, Polasek, Ozren, additional, Prince, Richard L., additional, Räikkönen, Katri, additional, Ralston, Stuart H., additional, Ripatti, Samuli, additional, Robbins, John A., additional, Rotter, Jerome I., additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Satterfield, Suzanne, additional, Schadt, Eric E., additional, Schipf, Sabine, additional, Scott, Laura, additional, Sehmi, Joban, additional, Shen, Jian, additional, Soo Shin, Chan, additional, Sigurdsson, Gunnar, additional, Smith, Shad, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Steinhagen-Thiessen, Elisabeth, additional, Streeten, Elizabeth A., additional, Styrkarsdottir, Unnur, additional, Swart, Karin M. A., additional, Tan, Sian-Tsung, additional, Tarnopolsky, Mark A., additional, Thompson, Patricia, additional, Thomson, Cynthia A., additional, Thorsteinsdottir, Unnur, additional, Tikkanen, Emmi, additional, Tranah, Gregory J., additional, Tuomilehto, Jaakko, additional, van Schoor, Natasja M., additional, Verma, Arjun, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Wactawski-Wende, Jean, additional, Walker, Mark, additional, Weedon, Michael N., additional, Welch, Ryan, additional, Wichmann, H.-Erich, additional, Widen, Elisabeth, additional, Williams, Frances M. K., additional, Wilson, James F., additional, Wright, Nicole C., additional, Xie, Weijia, additional, Yu, Lei, additional, Zhou, Yanhua, additional, Chambers, John C., additional, Döring, Angela, additional, van Duijn, Cornelia M., additional, Econs, Michael J., additional, Gudnason, Vilmundur, additional, Kooner, Jaspal S., additional, Psaty, Bruce M., additional, Spector, Timothy D., additional, Stefansson, Kari, additional, Rivadeneira, Fernando, additional, Uitterlinden, André G., additional, Wareham, Nicholas J., additional, Ossowski, Vicky, additional, Waterworth, Dawn, additional, Loos, Ruth J. F., additional, Karasik, David, additional, Harris, Tamara B., additional, Ohlsson, Claes, additional, and Kiel, Douglas P., additional
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- 2017
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47. Correction: Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
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Gorski, Mathias, primary, Most, Peter J. van der, additional, Teumer, Alexander, additional, Chu, Audrey Y., additional, Li, Man, additional, Mijatovic, Vladan, additional, Nolte, Ilja M., additional, Cocca, Massimiliano, additional, Taliun, Daniel, additional, Gomez, Felicia, additional, Li, Yong, additional, Tayo, Bamidele, additional, Tin, Adrienne, additional, Feitosa, Mary F., additional, Aspelund, Thor, additional, Attia, John, additional, Biffar, Reiner, additional, Bochud, Murielle, additional, Boerwinkle, Eric, additional, Borecki, Ingrid, additional, Bottinger, Erwin P., additional, Chen, Ming-Huei, additional, Chouraki, Vincent, additional, Ciullo, Marina, additional, Coresh, Josef, additional, Cornelis, Marilyn C., additional, Curhan, Gary C., additional, Adamo, Adamo Pio d’, additional, Dehghan, Abbas, additional, Dengler, Laura, additional, Ding, Jingzhong, additional, Eiriksdottir, Gudny, additional, Endlich, Karlhans, additional, Enroth, Stefan, additional, Esko, Tõnu, additional, Franco, Oscar H., additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Girotto, Giorgia, additional, Gottesman, Omri, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hancock, Stephen J., additional, Harris, Tamara B., additional, Helmer, Catherine, additional, Höllerer, Simon, additional, Hofer, Edith, additional, Hofman, Albert, additional, Holliday, Elizabeth G., additional, Homuth, Georg, additional, Hu, Frank B., additional, Huth, Cornelia, additional, Hutri-Kähönen, Nina, additional, Hwang, Shih-Jen, additional, Imboden, Medea, additional, Johansson, Åsa, additional, Kähönen, Mika, additional, König, Wolfgang, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kumar, Ashish, additional, Kutalik, Zoltan, additional, Lambert, Jean-Charles, additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, de Borst, Martin H., additional, Navis, Gerjan, additional, Swertz, Morris, additional, Liu, Yongmei, additional, Lohman, Kurt, additional, Loos, Ruth J. F., additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, McEvoy, Mark A., additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Metzger, Marie, additional, Mihailov, Evelin, additional, Mitchell, Paul, additional, Nauck, Matthias, additional, Oldehinkel, Albertine J., additional, Olden, Matthias, additional, WJH Penninx, Brenda, additional, Pistis, Giorgio, additional, Pramstaller, Peter P., additional, Probst-Hensch, Nicole, additional, Raitakari, Olli T., additional, Rettig, Rainer, additional, Ridker, Paul M., additional, Rivadeneira, Fernando, additional, Robino, Antonietta, additional, Rosas, Sylvia E., additional, Ruderfer, Douglas, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sala, Cinzia, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Scott, Rodney J., additional, Sedaghat, Sanaz, additional, Smith, Albert V., additional, Sorice, Rossella, additional, Stengel, Benedicte, additional, Stracke, Sylvia, additional, Strauch, Konstantin, additional, Toniolo, Daniela, additional, Uitterlinden, Andre G., additional, Ulivi, Sheila, additional, Viikari, Jorma S., additional, Völker, Uwe, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Vuckovic, Dragana, additional, Waldenberger, Melanie, additional, Wang, Jie Jin, additional, Yang, Qiong, additional, Chasman, Daniel I., additional, Tromp, Gerard, additional, Snieder, Harold, additional, Heid, Iris M., additional, Fox, Caroline S., additional, Köttgen, Anna, additional, Pattaro, Cristian, additional, Böger, Carsten A., additional, and Fuchsberger, Christian, additional
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- 2017
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48. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
- Author
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Gorski, Mathias, primary, van der Most, Peter J., additional, Teumer, Alexander, additional, Chu, Audrey Y., additional, Li, Man, additional, Mijatovic, Vladan, additional, Nolte, Ilja M., additional, Cocca, Massimiliano, additional, Taliun, Daniel, additional, Gomez, Felicia, additional, Li, Yong, additional, Tayo, Bamidele, additional, Tin, Adrienne, additional, Feitosa, Mary F., additional, Aspelund, Thor, additional, Attia, John, additional, Biffar, Reiner, additional, Bochud, Murielle, additional, Boerwinkle, Eric, additional, Borecki, Ingrid, additional, Bottinger, Erwin P., additional, Chen, Ming-Huei, additional, Chouraki, Vincent, additional, Ciullo, Marina, additional, Coresh, Josef, additional, Cornelis, Marilyn C., additional, Curhan, Gary C., additional, d’Adamo, Adamo Pio, additional, Dehghan, Abbas, additional, Dengler, Laura, additional, Ding, Jingzhong, additional, Eiriksdottir, Gudny, additional, Endlich, Karlhans, additional, Enroth, Stefan, additional, Esko, Tõnu, additional, Franco, Oscar H., additional, Gasparini, Paolo, additional, Gieger, Christian, additional, Girotto, Giorgia, additional, Gottesman, Omri, additional, Gudnason, Vilmundur, additional, Gyllensten, Ulf, additional, Hancock, Stephen J., additional, Harris, Tamara B., additional, Helmer, Catherine, additional, Höllerer, Simon, additional, Hofer, Edith, additional, Hofman, Albert, additional, Holliday, Elizabeth G., additional, Homuth, Georg, additional, Hu, Frank B., additional, Huth, Cornelia, additional, Hutri-Kähönen, Nina, additional, Hwang, Shih-Jen, additional, Imboden, Medea, additional, Johansson, Åsa, additional, Kähönen, Mika, additional, König, Wolfgang, additional, Kramer, Holly, additional, Krämer, Bernhard K., additional, Kumar, Ashish, additional, Kutalik, Zoltan, additional, Lambert, Jean-Charles, additional, Launer, Lenore J., additional, Lehtimäki, Terho, additional, de Borst, Martin H., additional, Navis, Gerjan, additional, Swertz, Morris, additional, Liu, Yongmei, additional, Lohman, Kurt, additional, Loos, Ruth J. F., additional, Lu, Yingchang, additional, Lyytikäinen, Leo-Pekka, additional, McEvoy, Mark A., additional, Meisinger, Christa, additional, Meitinger, Thomas, additional, Metspalu, Andres, additional, Metzger, Marie, additional, Mihailov, Evelin, additional, Mitchell, Paul, additional, Nauck, Matthias, additional, Oldehinkel, Albertine J., additional, Olden, Matthias, additional, WJH Penninx, Brenda, additional, Pistis, Giorgio, additional, Pramstaller, Peter P., additional, Probst-Hensch, Nicole, additional, Raitakari, Olli T., additional, Rettig, Rainer, additional, Ridker, Paul M., additional, Rivadeneira, Fernando, additional, Robino, Antonietta, additional, Rosas, Sylvia E., additional, Ruderfer, Douglas, additional, Ruggiero, Daniela, additional, Saba, Yasaman, additional, Sala, Cinzia, additional, Schmidt, Helena, additional, Schmidt, Reinhold, additional, Scott, Rodney J., additional, Sedaghat, Sanaz, additional, Smith, Albert V., additional, Sorice, Rossella, additional, Stengel, Benedicte, additional, Stracke, Sylvia, additional, Strauch, Konstantin, additional, Toniolo, Daniela, additional, Uitterlinden, Andre G., additional, Ulivi, Sheila, additional, Viikari, Jorma S., additional, Völker, Uwe, additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Vuckovic, Dragana, additional, Waldenberger, Melanie, additional, Jin Wang, Jie, additional, Yang, Qiong, additional, Chasman, Daniel I., additional, Tromp, Gerard, additional, Snieder, Harold, additional, Heid, Iris M., additional, Fox, Caroline S., additional, Köttgen, Anna, additional, Pattaro, Cristian, additional, Böger, Carsten A., additional, and Fuchsberger, Christian, additional
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- 2017
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49. Genetic variants associated with type 2 diabetes and adiposity and risk of intracranial and abdominal aortic aneurysms
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van 't Hof, Femke NG, primary, Vaucher, Julien, additional, Holmes, Michael V, additional, de Wilde, Arno, additional, Baas, Annette F, additional, Blankensteijn, Jan D, additional, Hofman, Albert, additional, Kiemeney, Lambertus ALM, additional, Rivadeneira, Fernando, additional, Uitterlinden, André G, additional, Vermeulen, Sita H, additional, Rinkel, Gabriël JE, additional, de Bakker, Paul IW, additional, and Ruigrok, Ynte M, additional
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- 2017
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50. Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture
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Zheng, Hou-Feng, Forgetta, Vincenzo, Hsu, Yi-Hsiang, Estrada, Karol, Rosello-Diez, Alberto, Leo, Paul J, Dahia, Chitra L, Park-Min, Kyung Hyun, Tobias, Jonathan H, Kooperberg, Charles, Kleinman, Aaron, Styrkarsdottir, Unnur, Liu, Ching-Ti, Uggla, Charlotta, Evans, Daniel S, Nielson, Carrie M, Walter, Klaudia, Pettersson-Kymmer, Ulrika, McCarthy, Shane, Eriksson, Joel, Kwan, Tony, Jhamai, Mila, Trajanoska, Katerina, Memari, Yasin, Min, Josine, Huang, Jie, Danecek, Petr, Wilmot, Beth, Li, Rui, Chou, Wen-Chi, Mokry, Lauren E, Moayyeri, Alireza, Claussnitzer, Melina, Cheng, Chia-Ho, Cheung, Warren, Medina-Gómez, Carolina, Ge, Bing, Chen, Shu-Huang, Choi, Kwangbom, Oei, Ling, Fraser, James, Kraaij, Robert, Hibbs, Matthew A, Gregson, Celia L, Paquette, Denis, Hofman, Albert, Wibom, Carl, Tranah, Gregory J, Marshall, Mhairi, Gardiner, Brooke B, Cremin, Katie, Auer, Paul, Hsu, Li, Ring, Sue, Tung, Joyce Y, Thorleifsson, Gudmar, Enneman, Anke W, Van Schoor, Natasja M, De Groot, Lisette CPGM, Van Der Velde, Nathalie, Melin, Beatrice, Kemp, John P, Christiansen, Claus, Sayers, Adrian, Zhou, Yanhua, Calderari, Sophie, Van Rooij, Jeroen, Carlson, Chris, Peters, Ulrike, Berlivet, Soizik, Dostie, Josée, Uitterlinden, Andre G, Williams, Stephen R, Farber, Charles, Grinberg, Daniel, LaCroix, Andrea Z, Haessler, Jeff, Chasman, Daniel I, Giulianini, Franco, Rose, Lynda M, Ridker, Paul M, Eisman, John A, Nguyen, Tuan V, Center, Jacqueline R, Nogues, Xavier, Garcia-Giralt, Natalia, Launer, Lenore L, Gudnason, Vilmunder, Mellström, Dan, Vandenput, Liesbeth, Amin, Najaf, Van Duijn, Cornelia M, Karlsson, Magnus K, Ljunggren, Östen, Svensson, Olle, Hallmans, Göran, Rousseau, François, Giroux, Sylvie, Bussière, Johanne, Arp, Pascal P, Koromani, Fjorda, Prince, Richard L, Lewis, Joshua R, Langdahl, Bente L, Hermann, A Pernille, Jensen, Jens-Erik B, Kaptoge, Stephen, Khaw, Kay-Tee, Reeve, Jonathan, Formosa, Melissa M, Xuereb-Anastasi, Angela, Åkesson, Kristina, McGuigan, Fiona E, Garg, Gaurav, Olmos, Jose M, Zarrabeitia, Maria T, Riancho, Jose A, Ralston, Stuart H, Alonso, Nerea, Jiang, Xi, Goltzman, David, Pastinen, Tomi, Grundberg, Elin, Gauguier, Dominique, Orwoll, Eric S, Karasik, David, Davey-Smith, George, AOGC Consortium, Smith, Albert V, Siggeirsdottir, Kristin, Harris, Tamara B, Zillikens, M Carola, Van Meurs, Joyce BJ, Thorsteinsdottir, Unnur, Maurano, Matthew T, Timpson, Nicholas J, Soranzo, Nicole, Durbin, Richard, Wilson, Scott G, Ntzani, Evangelia E, Brown, Matthew A, Stefansson, Kari, Hinds, David A, Spector, Tim, Cupples, L Adrienne, Ohlsson, Claes, Greenwood, Celia MT, UK10K Consortium, Jackson, Rebecca D, Rowe, David W, Loomis, Cynthia A, Evans, David M, Ackert-Bicknell, Cheryl L, Joyner, Alexandra L, Duncan, Emma L, Kiel, Douglas P, Rivadeneira, Fernando, Richards, J Brent, Rosello-Diez, Alberto [0000-0002-5550-9846], Kaptoge, Stephen [0000-0002-1155-4872], Khaw, Kay-Tee [0000-0002-8802-2903], Soranzo, Nicole [0000-0003-1095-3852], and Apollo - University of Cambridge Repository
- Subjects
Homeodomain Proteins ,Genotype ,Genome, Human ,Genetic Variation ,Genomics ,Sequence Analysis, DNA ,Bone and Bones ,White People ,Europe ,Wnt Proteins ,Disease Models, Animal ,Fractures, Bone ,Mice ,Gene Frequency ,Bone Density ,Animals ,Humans ,Exome ,Female ,Genetic Predisposition to Disease - Abstract
The extent to which low-frequency (minor allele frequency (MAF) between 1-5%) and rare (MAF ≤ 1%) variants contribute to complex traits and disease in the general population is mainly unknown. Bone mineral density (BMD) is highly heritable, a major predictor of osteoporotic fractures, and has been previously associated with common genetic variants, as well as rare, population-specific, coding variants. Here we identify novel non-coding genetic variants with large effects on BMD (ntotal = 53,236) and fracture (ntotal = 508,253) in individuals of European ancestry from the general population. Associations for BMD were derived from whole-genome sequencing (n = 2,882 from UK10K (ref. 10); a population-based genome sequencing consortium), whole-exome sequencing (n = 3,549), deep imputation of genotyped samples using a combined UK10K/1000 Genomes reference panel (n = 26,534), and de novo replication genotyping (n = 20,271). We identified a low-frequency non-coding variant near a novel locus, EN1, with an effect size fourfold larger than the mean of previously reported common variants for lumbar spine BMD (rs11692564(T), MAF = 1.6%, replication effect size = +0.20 s.d., Pmeta = 2 × 10(-14)), which was also associated with a decreased risk of fracture (odds ratio = 0.85; P = 2 × 10(-11); ncases = 98,742 and ncontrols = 409,511). Using an En1(cre/flox) mouse model, we observed that conditional loss of En1 results in low bone mass, probably as a consequence of high bone turnover. We also identified a novel low-frequency non-coding variant with large effects on BMD near WNT16 (rs148771817(T), MAF = 1.2%, replication effect size = +0.41 s.d., Pmeta = 1 × 10(-11)). In general, there was an excess of association signals arising from deleterious coding and conserved non-coding variants. These findings provide evidence that low-frequency non-coding variants have large effects on BMD and fracture, thereby providing rationale for whole-genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
- Published
- 2015
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