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14 results on '"Reiken, Steven"'

1. Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes

Author

Sleiman, Yvonne, primary, Reiken, Steven, additional, Charrabi, Azzouz, additional, Jaffré, Fabrice, additional, Sittenfeld, Leah R., additional, Pasquié, Jean-Luc, additional, Colombani, Sarah, additional, Lerman, Bruce B., additional, Chen, Shuibing, additional, Marks, Andrew R., additional, Cheung, Jim W., additional, Evans, Todd, additional, Lacampagne, Alain, additional, and Meli, Albano C., additional

Published
2023
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2. Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2

Author

Dridi, Haikel, primary, Liu, Yang, additional, Reiken, Steven, additional, Liu, Xiaoping, additional, Argyrousi, Elentina K., additional, Yuan, Qi, additional, Miotto, Marco C., additional, Sittenfeld, Leah, additional, Meddar, Andrei, additional, Soni, Rajesh Kumar, additional, Arancio, Ottavio, additional, Lacampagne, Alain, additional, and Marks, Andrew R., additional

Published
2023
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3. Defective cerebellar ryanodine receptor type 1 and endoplasmic reticulum calcium ‘leak’ in tremor pathophysiology

Author

Martuscello, Regina T., primary, Chen, Meng-Ling, additional, Reiken, Steven, additional, Sittenfeld, Leah R., additional, Ruff, David S., additional, Ni, Chun-Lun, additional, Lin, Chih-Chun, additional, Pan, Ming-Kai, additional, Louis, Elan D., additional, Marks, Andrew R., additional, Kuo, Sheng-Han, additional, and Faust, Phyllis L., additional

Published
2023
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4. Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity

Author

Zanou, Nadège, primary, Dridi, Haikel, additional, Reiken, Steven, additional, Imamura de Lima, Tanes, additional, Donnelly, Chris, additional, De Marchi, Umberto, additional, Ferrini, Manuele, additional, Vidal, Jeremy, additional, Sittenfeld, Leah, additional, Feige, Jerome N., additional, Garcia-Roves, Pablo M., additional, Lopez-Mejia, Isabel C., additional, Marks, Andrew R., additional, Auwerx, Johan, additional, Kayser, Bengt, additional, and Place, Nicolas, additional

Published
2021
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6. Intracellular calcium leak as a therapeutic target for RYR1-related myopathies

Author

Kushnir, Alexander, primary, Todd, Joshua J., additional, Witherspoon, Jessica W., additional, Yuan, Qi, additional, Reiken, Steven, additional, Lin, Harvey, additional, Munce, Ross H., additional, Wajsberg, Benjamin, additional, Melville, Zephan, additional, Clarke, Oliver B., additional, Wedderburn-Pugh, Kaylee, additional, Wronska, Anetta, additional, Razaqyar, Muslima S., additional, Chrismer, Irene C., additional, Shelton, Monique O., additional, Mankodi, Ami, additional, Grunseich, Christopher, additional, Tarnopolsky, Mark A., additional, Tanji, Kurenai, additional, Hirano, Michio, additional, Riazi, Sheila, additional, Kraeva, Natalia, additional, Voermans, Nicol C., additional, Gruber, Angela, additional, Allen, Carolyn, additional, Meilleur, Katherine G., additional, and Marks, Andrew R., additional

Published
2020
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7. Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits

Author

Lacampagne, Alain, primary, Liu, Xiaoping, additional, Reiken, Steven, additional, Bussiere, Renaud, additional, Meli, Albano C., additional, Lauritzen, Inger, additional, Teich, Andrew F., additional, Zalk, Ran, additional, Saint, Nathalie, additional, Arancio, Ottavio, additional, Bauer, Charlotte, additional, Duprat, Fabrice, additional, Briggs, Clark A., additional, Chakroborty, Shreaya, additional, Stutzmann, Grace E., additional, Shelanski, Michael L., additional, Checler, Frederic, additional, Chami, Mounia, additional, and Marks, Andrew R., additional

Published
2017
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8. Excess TGF-β mediates muscle weakness associated with bone metastases in mice

Author

Waning, David L, primary, Mohammad, Khalid S, additional, Reiken, Steven, additional, Xie, Wenjun, additional, Andersson, Daniel C, additional, John, Sutha, additional, Chiechi, Antonella, additional, Wright, Laura E, additional, Umanskaya, Alisa, additional, Niewolna, Maria, additional, Trivedi, Trupti, additional, Charkhzarrin, Sahba, additional, Khatiwada, Pooja, additional, Wronska, Anetta, additional, Haynes, Ashley, additional, Benassi, Maria Serena, additional, Witzmann, Frank A, additional, Zhen, Gehua, additional, Wang, Xiao, additional, Cao, Xu, additional, Roodman, G David, additional, Marks, Andrew R, additional, and Guise, Theresa A, additional

Published
2015
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10. Structure of a mammalian ryanodine receptor

Author

Zalk, Ran, primary, Clarke, Oliver B., additional, des Georges, Amédée, additional, Grassucci, Robert A., additional, Reiken, Steven, additional, Mancia, Filippo, additional, Hendrickson, Wayne A., additional, Frank, Joachim, additional, and Marks, Andrew R., additional

Published
2014
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14. Mitochondrial oxidative stress promotes atrial fibrillation

Author

Steven Reiken, Bi Xing Chen, Qi Yuan, Andrew R. Marks, Brent W. Osborne, Gaetano Santulli, Wenjun Xie, Xie, Wenjun, Santulli, Gaetano, Reiken, Steven R, Yuan, Qi, Osborne, Brent W, Chen, Bi Xing, and Marks, Andrew R.

Subjects
Mitochondrial ROS, Thiazepines, 030204 cardiovascular system & hematology, Pharmacology, Mitochondrion, medicine.disease_cause, Ryanodine receptor 2, Mitochondria, Heart, Mice, 0302 clinical medicine, Pathology, Age Factor, Myocytes, Cardiac, Heart metabolism, chemistry.chemical_classification, 0303 health sciences, Multidisciplinary, Ryanodine receptor, Age Factors, musculoskeletal system, Diseases--Animal models, cardiovascular system, Disease Susceptibility, Reactive Oxygen Specie, Intracellular, Human, medicine.medical_specialty, Mice, Transgenic, Biology, Article, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Heart Atria, 030304 developmental biology, Reactive oxygen species, Animal, Ryanodine Receptor Calcium Release Channel, Atrial fibrillation, Disease Models, Animal, Oxidative Stress, Endocrinology, chemistry, Calcium, Reactive Oxygen Species, Thiazepine, Cytology, Oxidative stress
Abstract

Oxidative stress has been suggested to play a role in the pathogenesis of atrial fibrillation (AF). Indeed, the prevalence of AF increases with age as does oxidative stress. However, the mechanisms linking redox state to AF are not well understood. In this study we identify a link between oxidative stress and aberrant intracellular Ca2+ release via the type 2 ryanodine receptor (RyR2) that promotes AF. We show that RyR2 are oxidized in the atria of patients with chronic AF compared with individuals in sinus rhythm. To dissect the molecular mechanism linking RyR2 oxidation to AF we used two murine models harboring RyR2 mutations that cause intracellular Ca2+ leak. Mice with intracellular Ca2+ leak exhibited increased atrial RyR2 oxidation, mitochondrial dysfunction, reactive oxygen species (ROS) production and AF susceptibility. Both genetic inhibition of mitochondrial ROS production and pharmacological treatment of RyR2 leakage prevented AF. Collectively, our results indicate that alterations of RyR2 and mitochondrial ROS generation form a vicious cycle in the development of AF. Targeting this previously unrecognized mechanism could be useful in developing effective interventions to prevent and treat AF.

Published
2015
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