9 results on '"R. M. Huber"'
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2. Kleinzelliges Lungenkarzinom – eine vernachlässigte Erkrankung
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R. M. Huber and H. Schmidberger
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Gynecology ,medicine.medical_specialty ,Oncology ,business.industry ,medicine ,Hematology ,business - Published
- 2017
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3. Was wirklich hilft bei viralen Infekten
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R. M. Huber and F. Gamarra
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General Medicine - Published
- 2008
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4. DEGRO 2004
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T Block, S. Röddiger, H. Fees, P. Feyer, T. Brunner, H. Karle, H. von Specht, M. Schwedas, A. Schmidt, H.-J. Ochel, N. Kröger, K. Müller, R. Waksman, M. Li, R. Sauer, S. Wesarg, A. Van Eck, D. Trog, R. Wilkowski, U. W. Tunn, K. Ikezaki, S. Könemann, L. Acimovic, Wolfgang Hinkelbein, Michael Bremer, E. Dühmke, J. Claßen, J.-I. Kotani, M. Püsken, J. Dudas, B. Pfistner, Christian Grehn, S. Ley, T. Martin, K. Maier-Hauff, A. Hartmann, Martin Weinmann, J. Kutzner, H. Vogel, I. Schmid, W. Lübcke, S. Roth, A. Krystek, Stefan Schultze-Mosgau, L. Freudenberg, J. Dahlke, P. K. Plinkert, Thomas Foitzik, M. Franz, C. Ludwig, O. Schorr, R. Wirtz, J. Klein, K. Krimmel, B. Weigel, A. K. Rustgi, J. Büntzel, W. Stahl, E. Pinnow, M. Graefen, S. Frühauf, K.-J. Buth, P. Reimann, E. A. Lazaridis, J. Lutterbach, C. Schleußner, R. Köster, Matthias Geiger, Beate Timmermann, D. A. Canos, Florian Auer, T. P. Nguyen, R. Anselm, T. M. Behr, Axel Müller, R. Bonnet, K. Leppert, Nicolaus Andratschke, Tilo Wiezorek, N. Prause, M. Tatagiba, M. Busch, N. Banz, M. van Kampen, P.-J. Prott, G. Schlichting, J. Körholz, M. Fritsch, B. Strauß, H. D. Böttcher, K. Schoenekaes, J. Schäfer, Renate Sieber, H. Jürgens, M. Schiebe, D. Milanovic, B. Al-Nawas, T. Beyer, B. Polivka, C. Fink, J. E. Panke, P. M. Messer, R. Kramer, C. F. Hess, D. Eßer, V. Steil, F. Bruns, Reinhard Thamm, R. Kumpf, M. Alber, U. Haverkamp, U. Mende, Christoph Thilmann, M. Bolck, M. W. Groß, Gunther Klautke, A. Zander, Sibylle Stärk, E. Tabbert, H. Taubert, M. Damrau, C. Weining, N. Franz, M. Puderbach, F. Melchert, L. Liu, W. Ito, S. Palkovic, B. Madry-Gevecke, T. Bölling, A. Kaffer, O. Micke, H. Schmidberger, M. Glashörster, A. Günther, S. Püttmann, A. Jordan, U. Claussen, Peter E. Huber, K. Lederer, S. Heiland, M. Niewald, H. Kühl, G. Gademann, Eugen Lang, B. Stieltjes, V. Ehemann, E. Horst, K. Heufelder, D. Fröhlich, S. Sepe, Roger E. Price, R. Bauer, E. Weiss, M. Reinhold, Moshe Schaffer, J.-C. Georgi, A. Dastbaz, Thomas Krieger, P. Hirnle, S. Garbe, D. Küstner, F. Pohl, N. Presselt, C. Voith, V. Meineke, P. Zogal, C. Herskind, S. Liesenfeld, F.-J. Prott, U. Kulka, Thomas Hendrik Knocke, T. Münzel, S. Kusche, Franz Rödel, Christian Ralf Gernhardt, C. Dilcher, Ute Küchenmeister, H. Alfia, N. Willich, D. Stratakis, G. Ramadori, R. Schmid, F. Zimmermann, L. Distel, K.-M. Mueller, V. Diehl, C. Höpfner, Frank Sieker, D. Cengiz, C. Plathow, E. Rolf, E. Schneider, W. Melzner, S.B. Schwarz, D. Sammour, D. Richter, I. Eichwurzel, H. Wassmann, A. L. Huston, B. Dietl, U. Melcher, F. Berthold, B. Kimmig, R. Mager, Richard Pötter, D. Drechsler, A. Lilienthal, A. Schmähl, M. Stuschke, A. Mencl, D. Schwab, H. Mörtel, O. Schneider, K.-W. Sykora, J. Willner, E. Lücke, N. Weidner, K. Hans-Jürgen, Sybille Gutwein, S. Kremp, R. Böhme, M. O. Klein, S. Nill, Hans-Günter Schaller, Matthias W. Beckmann, A. Feussner, M. Miemietz, A. Schmachtenberg, R. Seaborn, R.-P. Müller, Margret Rave-Fränk, A. Block, M. Gotthardt, I. Hacker, Á. Mayer, H.-W. Gottfried, G. Sakas, F. Nüsslin, M. Reinert, Markus Bohrer, H. Schmidt, A. Scheda, B. Dobler, T. Merz, K. Hansemann, K. A. Grötz, Grit Welzel, D. Isik, K. Wagner, P. Marini, C. Schäfer, M. Schrappe, T. Trinh, V. Rudat, M. Kowalski, T. Schneider, Daniela Schulz-Ertner, H. D. Weitmann, M. Henzel, I. Zuna, A. Nolte, Birgit Lang, K. Kian Ang, Thomas Wiegel, G. Seifert, A. Gossmann, D. van Beuningen, R. Wolfram, R. Hofheinz, K. Ludwig, T. Heil, M. Wittlinger, G. Lochhas, M. Houf, Robert Krempien, T. Averbeck, N. M. Blumstein, S. Astner, R. Willers, K.-J. Weber, J. Lorenzen, A. Krüll, U. Hädinger, C. Stoffregen, B. Pollock, S. Weidauer, U. Höller, M. Behe, B. Didinger, J. Gerstein, L. Bauer, S. Schill, M. Roebel, R. Schauer, J. Lamprecht, M. A. Leonardi, Otto A. Sauer, M. Molls, A. Varkonyi, Silke Tribius, U. Schäfer, V. Ghilescu, U. Keller, R. Galalae, E. Weiß, M. Buechler, W. Thiem, W. Winkelmann, S. N. Reske, T. Riedel, C. Int-Veen, Peter Geyer, A. Hunold, Barbara Röper, P. Peschke, M. Becker-Schiebe, I. Schulz, S. Bernhard, J. Fleckenstein, A. Hertel, H. Wördehoff, G. Müller, H. Grundtke, F. Rudolf, C. Böhme, Kurt Baier, R. Ullrich, S. Hesselmann, M. Raub, M. Schmidt, B. Hero, D. Sidow, C. Schöfl, U. Rühl, N. J. Volegova-Neher, C. Pöttgen, Stefan Glocker, Frank W. Hensley, Steven E. Schild, N. Dettmar, A. Quanz, R. Oppenkowski, A. Oettel, I. Seufert, U. Ganswindt, Volker Budach, H. Schoepgens, T. Fink, C. Ostertag, B. Milicic, R. C. Chan, F. Kiessling, J. Diebold, P. Rai, H.-U. Kauczor, H. Hoppe, P. Wolf, K. Litzenberger, M. Kappler, Peter Kneschaurek, Steffi Pigorsch, F. Momm, K. Kaube, Jörg Wiltfang, E. Koscielniak, J. Bohsung, J. Zumbe, K.-H. Grosser, N. Nüse, P. Erichsen, G. Kleinert, Chr. Rübe, P. Lukas, P. Spillner, C. Fehr, P. Benkel, O. Kölbl, N. Cordes, B. Hültenschmidt, Marc Bischof, N. J. Weissman, K. Yang, A. Engling, S. Milker-Zabel, Arndt-Christian Müller, B. Jeremic, D. Sandrock, Gabriele Hänsgen, C. Schul, Jörn Wulf, C. Fauser, M. Reiner, K. Dederer, M. Thelen, B. Grzyska, C. Evers, S. Daeuber, V. Platz, D. Riesenbeck, M. Erren, H. Zieher, W. Zeller, R. Bahrehmand, L. Wisser, K. Hoeffken, S. Kalb, M. Flentje, B. Greve, Claudia Waldhäusl, Fabian Fehlauer, Alessandra Siegmann, H. Czempiel, H. Stattaus, F. O’Tio, Vratislav Strnad, S. Frick, R. Kurek, E. Koepcke, R. Jäger, E. Severin, K. Krause, K. Pinsker, A.-R. Fischedick, P. Bach, S. Steinvorth, J. Blumberg, A. Stoßberg, Jörg Licher, S. X. Cavanaugh, R. Skripnitchenko, B. Mbarek, J. L. Martinez, V. van Lengen, Gabriele Beckmann, H. Saleske, E. Susanne, Christian Rübe, S. Mose, D. Rades, C. Scholz, P. Kupelian, T. W. Kaulich, M. Thoma, M. Stahl, A. Naszaly, M. R. Veldwijk, G. Radosavljevic-Asic, J. Schröder, Frank-Michael Köhn, L. Malaimare, Mathias Walke, K. Fischedick, M. Schmuecking, Gudrun Goitein, D. Hornung, T. Zabelina, N. Jirsak, K. Wolf, B. Schick, Mirko Nitsche, C. Pambor, K. Bajor, Isabell Braun, N. Czech, A. Sak, B. Hornig, Eric J. Bernhard, J. Meier zu Eissen, Michael Lotter, W. Hoffmann, L. Edler, Holger Hof, J. Lambert, M. Henke, C. Baum, B. Justus, W. Eyrich, I. Grießbach, T. Liehr, M. Wannenmacher, Peter Kessler, Klaus Eberlein, J. Dunst, A. E. Trappe, L. Hoffmann, S. Gruber, K. Mathias, S. Fruehauf, J. Hammer, J. H. Karstens, Erwin M. Röttinger, R. Schneider, G. Rothe, S. Milisavljevic, B. Pöllinger, H. Christiansen, A. Heinecke, Stefan Welz, B. Saile, W. Mühlnickel, M. Cartes, Rolf Kreienberg, M. Niemeyer, Claus Belka, T. Meyer, A. Nikoghosyan, Birgit Siekmeyer, K. Neubauer-Saile, Toralf Reimer, F. Bartel, M. Scheithauer, T. Osterham, Marc W. Münter, B. Theophil, N. Köhler, B. Krenkel, B. Hermann, M. Romano, T. Hölscher, T. Christian, M.-L. Sautter-Bihl, A. Bakai, K. Steckler, Franz Schwab, O. Bundschuh, S. Staar, G. Maurer, Johanna Gellermann, M. K. Körner, V. Hamelmann, T. Wenk, Jussi Moog, V. Heyl, S. Riedl, K. Lipson, T. Hehr, B. Röhrig, I. Schlöcker, I. Wildfang, H. Feldmann, D. Jürgen, A. Van Oosterhut, D. Vordermark, W. Schlegel, A. Kolkmeyer, R. Holy, N. Fridtjof, M. J. Eble, M. Pinkawa, S. Levegrün, P. Schneider, J. Debus, A. M. Frank, Andreas Engert, M. Bamberg, Reinhard Wurm, D. Treutler, M. Michaelis, Hans-Theodor Eich, I. Brecht, P. Gong, U. Keilholz, Martin Kocher, H. Salz, Oliver Koelbl, A. Schuchert, M. Osvath, H. Petrat, B. Asadpour, M. Birkner, B. Henzel, O. Hamid, Michael Baumann, G. Sigingan-Tek, B. Robrandt, B. Gerber, Ulf Lamprecht, J. Treuner, C. G. Rahl, G. Jakse, Roland Felix, N. Zöller, W. Krüger, F. Lohr, S.-K. Mai, C. Reddy, V. M. Shah, T. Olschewski, Wolfgang Harms, Martin Fuss, K. Markert, A. Kuechler, F. S. Schreiber, K.-H. Kloetzer, Jan Palm, F. Jänicke, R. Scholz, Y. Nour, W. Mohr, R. Exeler, D. Strauß, U. Oppitz, A. Kuhlmey, A. Schuck, K. Lang, A. Hille, A. Dani, R. Wehrmann, A. Hochhaus, L. Piasswilm, C. Winkler, B. van Oorschot, F.-W. Keffel, K. Jung, H. Gumprecht, R. Henschler, S. Swiderski, N. Waldöfner, Thilo Dörk, J. Thale, I. Griessbach, Dirk Bottke, F. Heinze, S. Roeddiger, S. Laufs, Detlef Imhoff, H. Annweiler, C. Verfaillie, M. Knips, R. Baumann, P. Barwig, P. Ketterer, B. Hentschel, Christiane Berns, M. Keller, B. Forthuber, G. S. Mintz, Martina Treiber, C. Moustakis, W. Huhnt, W. Oehler, U. Maurer, Juergen Wolf, H. Alheit, B. Kober, Guido Hildebrandt, R. Guttenberger, H. Vorwerk, Peter Vacha, N. Zamboglou, H. Job, O. Pradier, R. M. Huber, C. Pfaffendorf, Jürgen Füller, K. Engel, J. Zurheide, Artur Mayerhofer, D. Hahm, C. Nieder, U. Löhrs, J. Leonhardi, H. Thurmann, F. Willeke, D. Köppen, T. Dannenberg, G. Matschuck, E. Blank, B. von Gerstenberg-Helldorf, C. Seidel, H. Borchers, H. Lemnitzer, Rainer Souchon, A. Siefert, G. Strasssmann, K. Huppers, C. Schaal, H. Frommhold, W. Hosch, S. Theden, T. Wilhelm, U. Spahn, S. Höcht, Robert Semrau, J. Schultze, I. von Schorlemer, N. Riefenstahl, W. Reuschel, A.-M. Bentia, U. Glowalla, U. Schalldach, Verena Jendrossek, Amira Bajrovic, M. Schmücking, S.-W. Rha, B. Neu, M. Kuhlen, Markus Buchgeister, D. Treutier, T. Körschgen, Susanne Oertel, A. Schlieck, F. Schroeder, F. Paulsen, B. Knutzen, K. Kisters, F. van Valen, S. Tippelt, R. Pakala, J. Beck, Anca-Ligia Grosu, J. Hayen, Klaus Bratengeier, U. Militz, Raymonde Busch, S. Pachmann, M. Bache, M. Seebass, C. G. Blumstein, D. Lorenz, A. Johne, B. Kaminski, S. Neubauer, P. Zahn, Wolfgang A. Weber, M. Tine, M. Herbst, K. Junker, Thomas G. Wendt, Johannes Classen, C. Bilecen, S. Appold, P. Fritz, H. Koltze, M. Piroth, H. Molina, A. Zabel, C. B. Lumenta, B. Müller, Susanne Sehlen, Y. Kaplan, K. Brüchner, J. Güttler, S. Kunze, B. Schwald, C. Born, Rudolf Schwarz, E. Östreicher, G. Guenther, G. Friedel, Amir Abdollahi, Kathleen Grüschow, M. Glatzel, M. Richter, H. G. Strauß, Thomas Kuhnt, Klaus Herfarth, M. Guckenberger, K. Theodorou, A. Szasz, H. Schmitz, U. Kraus-Tiefenbacher, W. Budach, A. Winzer, Sabine Semrau, A. Mondry, M. Munnes, Peter Wust, W. Alberti, C. P. Schneider, G. Adam, S. Grehl, Stephen M. Hahn, B. Aydeniz, B. J. Salter, D. Wolff, P. Csere, P. Patonay, Robert Michael Hermann, S. Bäsecke, U. Koch, L. Schlenger, M. Rogger, T. Meinertz, R. Berndt-Skorka, V. Heinemann, Dieter Oetzel, Friedrich Wilhelm Neukam, H. Seibert, B. Rogge, C. Kappas, Anthony Lomax, Hans Geinitz, B. Sommer, K. Lehmann, A. Martin, I. Wolf, Rita Engenhart-Cabillic, C. Baumbach, G. G. Grabenbauer, Johannes Ring, K. Thompson, T. Wendt, S. Ahrens, C. Liebscher, G. Schaal, S. Steinkirchner, G. Horstmann, B. Wahlers, Ernst Klar, T. Loch, G. Assmann, W. G. McKenna, A. Mattke, S. Knaack, U. Ramm, P. Schüller, T. Gorbatov, D. Hellinga, W. Wagner, Hilbert Blank, W. Kleen, K. Janke, T. Welzel, W. Arnold, K. Fleckenstein, U. Gneveckow, K. Xydis, I. Haas, G. Stüben, B. Gagel, B. Wörmann, M. Ibrahim, A. Warszawski, A. Niesen, B. Elo, H. Kabisch, K. Meyer, Claus Rödel, H. Göbel, C. Weiß, U. Pinkert, N. Licht, Rainer Fietkau, Th. Herrmann, S. Bartelt, D. Lehmann, O. Baumgart, D. Jacob-Heutmann, P. Treusacher, H. Hollenhorst, J. Ficker, D. Baltas, C. Weber, B. Prümer, V. Kanellopoulos-Niemeyer, H. Jung, T. Hoelscher, Thomas Papadopoulos, M. Sure, O. Ott, H. Huland, Cordelia Hoinkis, F. Wenz, B. Bürger, H.-J. Kraus, Klaus-Josef Weber, M. Todorovic, F. Indenkämpen, J. Licner, Astrid Katzer, D. Lubgan, K.-H. Link, E. Liebermeister, B. Michaelis, G. Matnjani, M. Heintz, F. Guntrum, A. Grüneisen, A. Krauß, J. Schulte-Mönting, P. Achanta, Stephanie E. Combs, E. John, R. P. Baum, J. Haferanke, R. Feierabend, M. H. Seegenschmiedt, B. Rhein, M. Kolb, W. Spengler, A. Meyer, U. Niewöhner-Desbordes, A. Buchali, R. Mücke, K. Hamm, S. B. Müller, M. Kunkel, and K. Schönekaes
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Gynecology ,03 medical and health sciences ,medicine.medical_specialty ,0302 clinical medicine ,Oncology ,business.industry ,MEDLINE ,Medicine ,Radiology, Nuclear Medicine and imaging ,business ,030218 nuclear medicine & medical imaging - Published
- 2004
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5. Nucleosomes Indicate the in vitro Radiosensitivity of Irradiated Bronchoepithelial and Lung Cancer Cells
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Albrecht Bergner, Petra Stieber, Dorothea Nagel, Fernando Gamarra, Jutta Stief, Anke Mitlewski, R. M. Huber, and Stefan Holdenrieder
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Lung Neoplasms ,Cell Death ,business.industry ,Dose-Response Relationship, Radiation ,Enzyme-Linked Immunosorbent Assay ,Respiratory Mucosa ,General Medicine ,Biology ,medicine.disease ,Molecular biology ,In vitro ,Nucleosomes ,Dose–response relationship ,Apoptosis ,Cell culture ,Cancer cell ,Tumor Cells, Cultured ,medicine ,Humans ,Irradiation ,Radiosensitivity ,Lung cancer ,Nuclear medicine ,business - Abstract
Nucleosomes, which are typical cell death products, are elevated in the serum of cancer patients and are known to rapidly increase during radiotherapy. As both normal and malignant cells are damaged by irradiation, we investigated to which extent both cell types contribute to the release of nucleosomes. We cultured monolayers of normal bronchoepithelial lung cells (BEAS-2B, n = 18) and epithelial lung cancer cells (EPLC, n = 18), exposed them to various radiation doses (0, 10 and 30 Gy) and observed them for 5 days. Culture medium was changed every 24 h. Subsequently, nucleosomes were determined in the supernatant by the Cell Death Detection-ELISA(plus) (Roche Diagnostics). Additionally, the cell number was estimated after harvesting the cells in a second preparation. After 5 days, the cell number of BEAS-2B cultures in the irradiated groups (10 Gy: median 0.03 x 10(6) cells/culture, range 0.02-0.08 x 10(6) cells/culture; 30 Gy: median 0.08 x 10(6) cells/culture, range 0.02-0.14 x 10(6) cells/culture) decreased significantly (10 Gy: p = 0.005; 30 Gy p = 0.005; Wilcoxon test) compared to the non-irradiated control group (median 4.81 x 10(6) cells/culture, range 1.50-9.54 x 10(6) cells/culture). Consistently, nucleosomes remained low in the supernatant of non-irradiated BEAS-2B. However, at 10 Gy, BEAS-2B showed a considerably increasing release of nucleosomes, with a maximum at 72 h (before irradiation: 0.24 x 10(3) arbitrary units, AU, range 0.13-4.09 x 10(3) AU, and after 72 h: 1.94 x 10(3) AU, range 0.11-5.70 x 10(3) AU). At 30 Gy, the release was even stronger, reaching the maximum earlier (at 48 h, 11.09 x 10(3) AU, range 6.89-18.28 x 10(3) AU). In non-irradiated EPLC, nucleosomes constantly increased slightly. At 10 Gy, we observed a considerably higher release of nucleosomes in EPLC, with a maximum at 72 h (before irradiation: 2.79 x 10(3) AU, range 2.42-3.80 x 10(3) AU, and after 72 h: 7.16 x 10(3) AU, range 4.30-16.20 x 10(3) AU), which was more than 3.5 times higher than in BEAS-2B. At 30 Gy, the maximum (6.22 x 10(3) AU, range 5.13-9.71 x 10(3) AU) was observed already after 24 h. These results indicate that normal bronchoepithelial and malignant lung cancer cells contribute to the release of nucleosomes during irradiation in a dose- and time-dependent manner with cancer cells having a stronger impact at low doses.
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- 2004
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6. Contents Vol. 25, 2004
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Petra Stieber, Markus Valter, Michio M. Kawano, Nader Memari, Mikiko Fukui, Monika Carpelan-Holmström, N. Golmakani, Klaus Jung, Jutta Stief, Johanna Louhimo, Zhang Weidong, Rosistella Chiacchio, Yuichiro Hamanaka, Lanying Song, Albrecht Bergner, Jaume Trapé, Kohzoh Imai, Kozue Okano, Gerardo Rosati, Eduardo Osinaga, Wensheng Yan, Jinhua Zhang, M.J. Rasaee, Francesc Sant, Henrik Alfthan, Eleftherios P. Diamandis, Hugh S. Taylor, Hiroshi Yamashita, Lisa Kurlender, Carsten Stephan, Alexzander Asea, John-Desmond Robb, Mathias Warm, Patrick Micke, Rainer Wiewrodt, Tomoko Nakano-Hashimoto, Katerina Oikonomopoulou, Phil D. Rye, Heidi Albrecht, Chien-Yun Hsiang, P.D. Rye, Shilin Song, K. Omidfar, M. Taghikhani, Kai Becker, Rafael Molina, Roland Buhl, Peter Mallmann, Dionyssios Katsaros, Tin-Yun Ho, Shih-Lu Wu, Torgny Stigbrand, Iacovos P. Michael, Saba Khan, Andreas Faldum, Uwe-Jochen Göhring, Ulf-Håkan Stenman, Danielle B. Lane, Fernando Gamarra, R. M. Huber, Domenico De Sanctis, Yuichiro Maruta, Tong Zhao, Berthold Fischer, Jan G. Hengstler, Iacovos Michael, Shen Wenlv, Luigi Manzione, Heikki Järvinen, Giorgio Reggiardo, M. Forouzandeh, George M. Yousef, Caj Haglund, Thomas Schöndorf, Stefan Holdenrieder, Maria A. Bausero, Diana T. Page, Maria-Paz Weisshaar, Min Deng, Dorothea Nagel, Nicole M.A. White, Fernando Bittinger, Lewin Eisele, Thomas J. Rutherford, T. Stigbrand, Roland Fechteler, Yuji Hinoda, H. Modjtahedi, Wu Licun, Markus Hoopmann, Cui Yazhou, Yutaka Suehiro, Martina Becker, Carla A. Borgoño, and Anke Mitlewski
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General Medicine - Published
- 2004
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7. Subject Index Vol. 25, 2004
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Min Deng, Phil D. Rye, Andreas Faldum, Dorothea Nagel, Kohzoh Imai, Eduardo Osinaga, Patrick Micke, Rainer Wiewrodt, Fernando Bittinger, Klaus Jung, Wensheng Yan, Lewin Eisele, Zhang Weidong, Roland Fechteler, P.D. Rye, Alexzander Asea, Giorgio Reggiardo, Yuji Hinoda, Eleftherios P. Diamandis, Shilin Song, Iacovos Michael, Jaume Trapé, Hugh S. Taylor, Heidi Albrecht, Rafael Molina, Maria A. Bausero, Diana T. Page, Markus Hoopmann, H. Modjtahedi, Jutta Stief, M. Forouzandeh, Henrik Alfthan, Peter Mallmann, Wu Licun, Lanying Song, N. Golmakani, K. Omidfar, Domenico De Sanctis, Tomoko Nakano-Hashimoto, Albrecht Bergner, Mikiko Fukui, Yuichiro Hamanaka, Cui Yazhou, Francesc Sant, Iacovos P. Michael, Nader Memari, Danielle B. Lane, Martina Becker, Kozue Okano, Gerardo Rosati, Shih-Lu Wu, Kai Becker, Jinhua Zhang, Anke Mitlewski, M.J. Rasaee, T. Stigbrand, Ulf-Håkan Stenman, Yuichiro Maruta, Jan G. Hengstler, Hiroshi Yamashita, Lisa Kurlender, Heikki Järvinen, Monika Carpelan-Holmström, Petra Stieber, Markus Valter, Torgny Stigbrand, Michio M. Kawano, Dionyssios Katsaros, Luigi Manzione, John-Desmond Robb, Rosistella Chiacchio, Saba Khan, Mathias Warm, Uwe-Jochen Göhring, Fernando Gamarra, M. Taghikhani, Tin-Yun Ho, Carsten Stephan, Shen Wenlv, Berthold Fischer, Roland Buhl, R. M. Huber, Nicole M.A. White, Tong Zhao, Chien-Yun Hsiang, Thomas J. Rutherford, Johanna Louhimo, Katerina Oikonomopoulou, Maria-Paz Weisshaar, Yutaka Suehiro, Carla A. Borgoño, George M. Yousef, Caj Haglund, Thomas Schöndorf, and Stefan Holdenrieder
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Index (economics) ,Statistics ,Subject (documents) ,General Medicine ,Mathematics - Published
- 2004
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8. Lung function in adult patients with cystic fibrosis after using the eFlow® rapid for one year
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Susanne Naehrig, Susanne M. Lang, Helmut Schiffl, R. M. Huber, and Rainald Fischer
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Cystic Fibrosis ,Vital Capacity ,Treatment outcome ,lcsh:Medicine ,inhalation time ,Respiratory physiology ,Cystic fibrosis ,nebuliser ,eFlow® rapid ,Young Adult ,Aerosol delivery ,Forced Expiratory Volume ,Humans ,Medicine ,Prospective Studies ,Lung ,Lung function ,Aerosols ,inhalation ,Inhalation ,Adult patients ,business.industry ,Research ,Nebulizers and Vaporizers ,lcsh:R ,lung function ,General Medicine ,Middle Aged ,respiratory system ,medicine.disease ,Anti-Bacterial Agents ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Female ,Radiology ,business - Abstract
Background The new generation nebuliser PARI eFlow® rapid allows a highly efficient aerosol delivery at reduced inhalation time. However, lung function data during long-term use of this device are not available until now. Methods 70 clinically stable adult cystic fibrosis patients participated in this observation study. Lung function tests were performed prospectively 12 weeks after and again 9 to 12 months after switching the inhalation device from a conventional jet nebulizer to the PARI eFlow® rapid. Lung function data were collected retrospectively from the visits 1 year as well as 12 weeks prior to the switch-over. Lung function data for all time points were only available for 59 patients. Treatment time and patient's satification were recorded for both conventional and new nebuliser in all 70 patients. Results After 1 year of inhalation with eFlow® rapid, the mean change in FEV1% was -- 1.4% (n = 59 patients). The decrease in FEV1 was smaller than the change in FEV1 after 1 year of inhalation with the conventional jet nebuliser (control period, -3.1%), although this difference was not statistically significant. The same effect was seen in MEF25[%] '(-2.6% with conventional nebuliser compared to --1.6% after eFlow® rapid). Concerning the FVC, there was a greater improvement after 1 year of inhalation with the eFlow® rapid than with the jet nebuliser (+ 2.9% vs. +1.1%). For PEF%, there was an increase during the control period, whereas after inhalation with eFlow® rapid there was a decrease (+1.1% vs. --2.9%). All changes were not significantly different. The eFlow® rapid reduced total daily inhalation time by two-thirds (conventional nebuliser: 31.1 min/day; eFlow® rapid: 10.2 min/day, n = 70 patients) Conclusion Inhalation with the new nebuliser eFlow rapid does not alter FEV1, FVC or PEF significantly after 1 year of inhalation. The treatment time could be reduced significantly by the eFlow® rapid.
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- 2011
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9. Reduced expression of bax in small cell lung cancer cells is not sufficient to induce cisplatin-resistance
- Author
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Albrecht Bergner, R. M. Huber, and J Biagosch
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Lung Neoplasms ,Cell Survival ,Clone (cell biology) ,lcsh:Medicine ,Transfection ,Bcl-2-associated X protein ,Cell Line, Tumor ,Tumor Cells, Cultured ,medicine ,Humans ,Carcinoma, Small Cell ,RNA, Small Interfering ,neoplasms ,B cell ,bcl-2-Associated X Protein ,Regulation of gene expression ,Cisplatin ,biology ,Research ,lcsh:R ,General Medicine ,Actins ,Cell biology ,Gene Expression Regulation, Neoplastic ,medicine.anatomical_structure ,Drug Resistance, Neoplasm ,Apoptosis ,Cell culture ,biology.protein ,Cancer research ,medicine.drug - Abstract
Resistance to cisplatin in the course of chemotherapy contributes to the poor prognosis of small cell lung cancer (SCLC). B cell lymphoma-2 is the founding member of a large family of proteins that either promote or inhibit apoptosis. We aimed at investigating if the pro-apoptotic members Bad, Bax, Bim and Bid are involved in cisplatin-resistance. Cisplatin-resistance in the SCLC cell line H1339 was induced by repetitive exposure to cisplatin. Protein expression was quantified by Western Blot and immuno-fluorescence analysis. Protein expression was altered using siRNA interference. Four "cycles" of 0.5 μg/ml cisplatin led to partial cisplatin-resistance in H1339 cells. The expression of Bad, Bim and Bid was comparable in naïve and resistant cells while the expression of Bax was reduced in the resistant clone. But, reducing Bax expression in naïve cells did not lead to altered cisplatin sensitivity neither in H1339 nor in H187 SCLC cells. We conclude that the reduced Bax expression after exposure to cisplatin is not sufficient to induce cis-platin-resistance in SCLC cells.
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- 2010
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