1. Complement activation is associated with crescent formation in IgA nephropathy
- Author
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Kazuhiko Tsuruya, Kinta Hatakeyama, Chiho Ohbayashi, Takahiro Kawano, Kengo Fujiki, Takaaki Kosugi, Ken-ichi Samejima, Katsuhiko Morimoto, Hiroe Itami, Hideo Tsushima, Shigeo Hara, Keisuke Okamoto, and Hiromichi Kitada
- Subjects
Male ,0301 basic medicine ,Kidney Glomerulus ,Fluorescent Antibody Technique ,Complement Membrane Attack Complex ,urologic and male genital diseases ,Gastroenterology ,Pathogenesis ,0302 clinical medicine ,Japan ,Complement Activation ,Aged, 80 and over ,biology ,Complement C3 ,General Medicine ,Middle Aged ,Mannose-Binding Protein-Associated Serine Proteases ,030220 oncology & carcinogenesis ,Female ,MASP2 ,Complement Factor B ,Adult ,medicine.medical_specialty ,Adolescent ,Urinary system ,Renal function ,Complement factor B ,Pathology and Forensic Medicine ,Nephropathy ,Young Adult ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Molecular Biology ,Aged ,Retrospective Studies ,Properdin ,business.industry ,Glomerulonephritis, IGA ,Complement System Proteins ,Cell Biology ,medicine.disease ,Immunoglobulin A ,Complement system ,030104 developmental biology ,Microscopy, Fluorescence ,biology.protein ,Immunoglobulin Light Chains ,business - Abstract
IgA nephropathy (IgAN) is common chronic glomerulonephritis with variable prognosis, ranging from minor urinary abnormalities to end-stage renal disease. The revised Oxford classification of IgAN explains that cellular/fibrocellular crescents are associated with poor renal prognosis, proposing an extension to the MEST-C score. C3 immunofluorescent staining follows a distribution similar to IgA staining. Therefore, complement activation was reported to play a pivotal role in IgAN pathogenesis. This study included 132 IgAN patients diagnosed by renal biopsies. The clinical parameters at the time of the biopsies were obtained from patient data records. We classified the patients into C ≥ 1 and C0 groups, and compared clinical, light microscopic, and immunofluorescent features. In the C ≥ 1 group, 2 (1.5%) and 31 (23.5%) patients were assigned to C2 and C1, respectively. The remaining 99 patients (75%) were classified as C0. The C ≥ 1 group had lower average age and rate of hypertension, and higher score of urinary occult blood and E score. The C ≥ 1 group had significantly higher average immunofluorescence scores for IgA, C5b-9, mannose-associated serine protease (MASP) 1/3, MASP2, properdin, factor B, and kappa. The steroid use rate was significantly higher in the C ≥ 1 group. During the follow-up period of 2.90 years on average, the rate of renal dysfunction was not significantly different between groups. Crescent formation in IgAN was associated with activation of the lectin and alternative pathways. The C ≥ 1 group had significantly increased use of steroids, which probably caused comparable renal function during the follow-up period.
- Published
- 2020