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Your search keyword '"Pofi, Riccardo"' showing total 17 results
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17 results on '"Pofi, Riccardo"'

1. Cardiac magnetic resonance reveals biventricular impairment in Cushing’s syndrome: a multicentre case-control study

Author

Feola, Tiziana, primary, Cozzolino, Alessia, additional, De Alcubierre, Dario, additional, Pofi, Riccardo, additional, Galea, Nicola, additional, Catalano, Carlo, additional, Simeoli, Chiara, additional, Di Paola, Nicola, additional, Campolo, Federica, additional, Pivonello, Rosario, additional, Isidori, Andrea M., additional, and Giannetta, Elisa, additional

Published
2024
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3. Pituitary adenoma consistency affects postoperative hormone function: a retrospective study

Author

De Alcubierre, Dario, primary, Puliani, Giulia, additional, Cozzolino, Alessia, additional, Hasenmajer, Valeria, additional, Minnetti, Marianna, additional, Sada, Valentina, additional, Martines, Valentina, additional, Zaccagnino, Antonella, additional, Ruggeri, Andrea Gennaro, additional, Pofi, Riccardo, additional, Sbardella, Emilia, additional, and Venneri, Mary Anna, additional

Published
2023
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4. 11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial

Author

Othonos, Nantia, primary, Pofi, Riccardo, additional, Arvaniti, Anastasia, additional, White, Sarah, additional, Bonaventura, Ilaria, additional, Nikolaou, Nikolaos, additional, Moolla, Ahmad, additional, Marjot, Thomas, additional, Stimson, Roland H., additional, van Beek, André P., additional, van Faassen, Martijn, additional, Isidori, Andrea M., additional, Bateman, Elizabeth, additional, Sadler, Ross, additional, Karpe, Fredrik, additional, Stewart, Paul M., additional, Webster, Craig, additional, Duffy, Joanne, additional, Eastell, Richard, additional, Gossiel, Fatma, additional, Cornfield, Thomas, additional, Hodson, Leanne, additional, Jane Escott, K., additional, Whittaker, Andrew, additional, Kirik, Ufuk, additional, Coleman, Ruth L., additional, Scott, Charles A. B., additional, Milton, Joanne E., additional, Agbaje, Olorunsola, additional, Holman, Rury R., additional, and Tomlinson, Jeremy W., additional

Published
2023
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7. Evidenza RM degli effetti del Protocollo Stupp nel trattamento di un adenoma ipofisario atipico

Author

Sbardella, Emilia, primary, Puliani, Giulia, additional, Pofi, Riccardo, additional, De Alcubierre, Dario, additional, Cozzolino, Alessia, additional, Hasenmajer, Valeria, additional, Graziadio, Chiara, additional, Gianfrilli, Daniele, additional, Pozza, Carlotta, additional, Giannetta, Elisa, additional, Lenzi, Andrea, additional, Minniti, Giuseppe, additional, and Isidori, Andrea M., additional

Published
2021
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11. Evidenza RMN di metastasi ipofisaria isolata da carcinoma polmonare

Author

De Alcubierre, Dario, primary, Puliani, Giulia, additional, Sbardella, Emilia, additional, Pofi, Riccardo, additional, Cozzolino, Alessia, additional, Tenuta, Marta, additional, Pozza, Carlotta, additional, Gianco, Francesca, additional, Giangaspero, Felice, additional, Giannetta, Elisa, additional, Lenzi, Andrea, additional, and Isidori, Andrea M., additional

Published
2021
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12. Tumori neuroendocrini della tiroide: non solo carcinoma midollare

Author

Cozzolino, Alessia, primary, Sesti, Franz, additional, Feola, Tiziana, additional, Puliani, Giulia, additional, Pofi, Riccardo, additional, Di Gioia, Cira, additional, Nardi, Francesco, additional, Giannetta, Elisa, additional, Isidori, Andrea M., additional, and Lenzi, Andrea, additional

Published
2019
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13. Phosphodiesterase-5 inhibition preserves renal hemodynamics and function in mice with diabetic kidney disease by modulating miR-22 and BMP7

Author

Pofi, Riccardo, primary, Fiore, Daniela, additional, De Gaetano, Rita, additional, Panio, Giuseppe, additional, Gianfrilli, Daniele, additional, Pozza, Carlotta, additional, Barbagallo, Federica, additional, Xiang, Yang Kevin, additional, Giannakakis, Konstantinos, additional, Morano, Susanna, additional, Lenzi, Andrea, additional, Naro, Fabio, additional, Isidori, Andrea M., additional, and Venneri, Mary Anna, additional

Published
2017
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14. Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials

Author

Giannetta, Elisa, Feola, T., Gianfrilli, Daniele, Pofi, Riccardo, Dall'Armi, V., Badagliacca, Roberto, Barbagallo, Federica, Lenzi, Andrea, Isidori, Andrea, and Feola, Tiziana

Subjects
Male, medicine.medical_specialty, Cardiac index, Sildenafil, Phosphodiesterase-5, Left ventricular hypertrophy, Placebo, Phosphodiesterase-5, Heart failure, Hypertension, Endothelial function, Cardiac remodeling, Cardiac hypertrophy, Erectile dysfunction, Sildenafil, Pulmonary hypertension, Pulmonary hypertension, law.invention, Erectile Dysfunction, Randomized controlled trial, Afterload, law, Internal medicine, medicine, Humans, Randomized Controlled Trials as Topic, Cardiac remodeling, Medicine(all), Heart Failure, Ejection fraction, business.industry, Reproducibility of Results, Endothelial function, General Medicine, Phosphodiesterase 5 Inhibitors, medicine.disease, Cardiac hypertrophy, Tolerability, Heart failure, Hypertension, Cardiology, Endothelium, Vascular, business, Research Article
Abstract

Background The myocardial effects of phosphodiesterase type 5 inhibitors (PDE5i) have recently received consideration in several preclinical studies. The risk/benefit ratio in humans remains unclear. Methods We performed a meta-analysis of randomized, placebo-controlled trials (RCTs) to evaluate the efficacy and safety of PDE5i on cardiac morphology and function. From March 2012 to December 2013 (update: May 2014), we searched English-language studies from MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and SCOPUS-selecting RCTs of continuous PDE5i administration that reported cardiovascular outcomes: cardiac geometry and performance, afterload, endothelial function and safety. The pooled estimate of a weighted mean difference between treatment and placebo was obtained for all outcomes using a random effects model. A test for heterogeneity was performed and the I2 statistic calculated. Results Overall, 1,622 subjects were treated, with 954 randomized to PDE5i and 772 to placebo in 24 RCTs. According to our analysis, sustained PDE5 inhibition produced: (1) an anti-remodeling effect by reducing cardiac mass (−12.21 g/m2, 95% confidence interval (CI): −18.85; −5.57) in subjects with left ventricular hypertrophy (LVH) and by increasing end-diastolic volume (5.00 mL/m2; 95% CI: 3.29; 6.71) in non-LVH patients; (2) an improvement in cardiac performance by increasing cardiac index (0.30 L/min/m2, 95% CI: 0.202; 0.406) and ejection fraction (3.56%, 95% CI: 1.79; 5.33). These effects are parallel to a decline of N-terminal-pro brain natriuretic peptide (NT-proBNP) in subjects with severe LVH (−486.7 pg/ml, 95% CI: −712; -261). PDE5i administration also produced: (3) no changes in afterload parameters and (4) an improvement in flow-mediated vasodilation (3.31%, 95% CI: 0.53; 6.08). Flushing, headache, epistaxis and gastric symptoms were the commonest side effects. Conclusions This meta-analysis suggests for the first time that PDE5i have anti-remodeling properties and improve cardiac inotropism, independently of afterload changes, with a good safety profile. Given the reproducibility of the findings and tolerability across different populations, PDE5i could be reasonably offered to men with cardiac hypertrophy and early stage heart failure. Given the limited gender data, a larger trial on the sex-specific response to long-term PDE5i treatment is required. Electronic supplementary material The online version of this article (doi:10.1186/s12916-014-0185-3) contains supplementary material, which is available to authorized users.

Published
2014
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17. A prospective study on contrast-enhanced magnetic resonance imaging of testicular lesions: distinctive features of Leydig cell tumours

Author

Manganaro, Lucia, primary, Vinci, Valeria, additional, Pozza, Carlotta, additional, Saldari, Matteo, additional, Gianfrilli, Daniele, additional, Pofi, Riccardo, additional, Bernardo, Silvia, additional, Cantisani, Vito, additional, Lenzi, Andrea, additional, Scialpi, Michele, additional, Catalano, Carlo, additional, and Isidori, Andrea M., additional

Published
2015
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