1. Incidence and risk factors for recurrent Henoch-Schönlein purpura in children from a 16-year nationwide database
- Author
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Chien-Yu Lin, Yu-Hsuan Kao, Wei-Te Lei, Shyh-Dar Shyur, Szu-Hung Chu, Po-Li Tsai, Yu-Wen Lin, Shu-I Wu, and Li-Ching Fang
- Subjects
Male ,medicine.medical_specialty ,lcsh:Diseases of the musculoskeletal system ,Henoch-Schonlein purpura ,Adolescent ,Databases, Factual ,IgA Vasculitis ,Taiwan ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Rheumatology ,Recurrence ,Risk Factors ,030225 pediatrics ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Child ,Glucocorticoids ,Steroid ,Survival analysis ,030203 arthritis & rheumatology ,Proportional hazards model ,business.industry ,Incidence ,Incidence (epidemiology) ,Hazard ratio ,lcsh:RJ1-570 ,Nationwide database ,Infant ,lcsh:Pediatrics ,medicine.disease ,Survival Analysis ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Henoch-Scholein Purpura ,Female ,lcsh:RC925-935 ,Recurrent ,business ,Research Article ,Cohort study - Abstract
Background The recurrence rate of Henoch-Schönlein purpura (HSP) is 2.7%–30%, with varied average intervals between the first and second episodes. Few studies have explored the incidence and risk factors for recurrent HSP. Methods We used a 16-year nationwide database to analyze the incidence of recurrent HSP. Patients with HSP were identified, and risk factors for recurrent HSP were explored. Kaplan-Meier and Cox regression model analyses were performed, and covariates were adjusted in the multivariate model. Results From January 1, 1997 to December 31, 2012, among 2,886,836 individuals in the National Health Insurance Research Database, 1002 HSP patients aged 10 days (adjusted hazard ratio, 8.13; 95%CI, 2.51–26.36; p 10 days should be notified regarding the possibility of recurrence. Electronic supplementary material The online version of this article (10.1186/s12969-018-0247-8) contains supplementary material, which is available to authorized users.
- Published
- 2018