1. Remission of metabolic syndrome following a 15-week low-calorie lifestyle change program for weight loss
- Author
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Robert Malcolm, Jennifer D. Lundgren, Martin Binks, and Patrick M. O'Neil
- Subjects
Blood Glucose ,Male ,medicine.medical_specialty ,Waist ,Calorie ,Diet, Reducing ,animal diseases ,Endocrinology, Diabetes and Metabolism ,Medicine (miscellaneous) ,Caloria ,Weight loss ,Internal medicine ,Weight Loss ,Dietary Carbohydrates ,medicine ,Humans ,heterocyclic compounds ,Triglycerides ,Metabolic Syndrome ,Nutrition and Dietetics ,biology ,business.industry ,Cholesterol, HDL ,Remission Induction ,Middle Aged ,medicine.disease ,biology.organism_classification ,Combined Modality Therapy ,Obesity ,Exercise Therapy ,nervous system diseases ,Logistic Models ,Blood pressure ,Endocrinology ,nervous system ,Body Composition ,health occupations ,Female ,Waist Circumference ,medicine.symptom ,Metabolic syndrome ,business ,Body mass index - Abstract
To evaluate the rate of remission of metabolic syndrome (Met Syn) among patients undergoing a brief, low-calorie lifestyle change weight loss intervention and to compare the baseline characteristics of patients who were remitted and not remitted from Met Syn at post-treatment.Obese adults (N=36) meeting criteria for Met Syn enrolled in an outpatient fee-for-service behavioral weight loss intervention. Participants were assessed on key Met Syn variables (waist circumference, blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol and fasting blood glucose) at pre- and post-treatment.The majority of patients (61%) responded to treatment after a 9.9% mean weight loss. Although Met Syn responders did not differ significantly from Met Syn non-responders on any baseline Met Syn criterion variable, responders had significantly lower baseline body mass indices (BMI; kg/m(2)) and met criteria for fewer baseline Met Syn variables. As expected, Met Syn responders, compared with Met Syn non-responders, had significantly lower post-treatment waist circumference, systolic and diastolic blood pressures, triglycerides and fasting blood glucose. Patient groups did not differ significantly on weight lost (kg or %), or on the proportion of patients losingor =10% of initial body weight.In a community population, Met Syn responds to weight loss through a low-calorie lifestyle intervention; for some patients, however, the recommended 10% weight loss may not be enough for Met Syn remission.
- Published
- 2008