231 results on '"Orazi, A"'
Search Results
2. Deterioration effects of X-ray irradiation in artificially aged parchment
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Mercuri, Fulvio, primary, Cicero, Cristina, additional, Paoloni, Stefano, additional, Zammit, Ugo, additional, Orazi, Noemi, additional, Vadrucci, Monia, additional, Severini, Leonardo, additional, and Mazzuca, Claudia, additional
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- 2023
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3. Jupiter-like planets might be common in a low-density environment
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Gratton, Raffaele, primary, Mesa, Dino, additional, Bonavita, Mariangela, additional, Zurlo, Alice, additional, Marino, Sebastian, additional, Kervella, Pierre, additional, Desidera, Silvano, additional, D’Orazi, Valentina, additional, and Rigliaco, Elisabetta, additional
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- 2023
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4. Non-face emojis in digital marketing: Effects, contingencies, and strategic recommendations
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Davide Christian Orazi, Bhoomija Ranjan, and Yimin Cheng
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Marketing ,Economics and Econometrics ,Business and International Management - Published
- 2023
5. Strategic Asset Allocation of a Reserves’ Portfolio: Hedging Against Shocks
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Mario L. Torriani, Pablo Orazi, and Matias Vicens
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Economics and Econometrics - Published
- 2022
6. The International Consensus Classification of myelodysplastic syndromes and related entities
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Robert P, Hasserjian, Attilio, Orazi, Alberto, Orfao, Maria, Rozman, and Sa A, Wang
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Cell Biology ,General Medicine ,Molecular Biology ,Pathology and Forensic Medicine - Abstract
The International Consensus Classification (ICC) of myeloid neoplasms and acute leukemia has updated the classification of myelodysplastic syndromes (MDSs) and placed MDS in a broader group of clonal cytopenias that includes clonal cytopenia of undetermined significance (CCUS) and related entities. Although subject to some interobserver variability and lack of specificity, morphologic dysplasia remains the main feature that distinguishes MDS from other clonal cytopenias and defines MDS as a hematologic malignancy. The ICC has introduced some changes in the definition of MDS whereby some cases categorized as MDS based on cytogenetic abnormalities are now classified as CCUS, while SF3B1 and multi-hit TP53 mutations are now considered to be MDS-defining in a cytopenic patient. The ICC has also recognized several cytogenetic and molecular abnormalities that reclassify some cases of MDS with excess blasts as acute myeloid leukemia (AML) and has introduced a new MDS/AML entity that encompasses cases with 10-19% blasts that lie on the continuum between MDS and AML. Two new genetically defined categories of MDS have been introduced: MDS with mutated SF3B1 and MDS with mutated TP53, the latter requiring bi-allelic aberrations in the TP53 gene. The entity MDS, unclassifiable has been eliminated. These changes have resulted in an overall simplification of the MDS classification scheme from 8 separate entities (including 1 that was genetically defined) in the revised 4th edition WHO classification to 7 separate entities (including 3 that are genetically defined) in the ICC.
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- 2022
7. The International Consensus Classification of acute myeloid leukemia
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Olga K. Weinberg, Anna Porwit, Attilio Orazi, Robert P. Hasserjian, Kathryn Foucar, Eric J. Duncavage, and Daniel A. Arber
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Cell Biology ,General Medicine ,Molecular Biology ,Pathology and Forensic Medicine - Published
- 2022
8. The international consensus classification of mastocytosis and related entities
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Roos J. Leguit, Sa A. Wang, Tracy I. George, Alexandar Tzankov, and Attilio Orazi
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Cell Biology ,General Medicine ,Molecular Biology ,Pathology and Forensic Medicine - Published
- 2022
9. EAHP 2020 workshop proceedings, pediatric myeloid neoplasms
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R. J. Leguit, A. Orazi, N. Kucine, H. M. Kvasnicka, U. Gianelli, D. A. Arber, A. Porwit, and M. Ponzoni
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Cell Biology ,General Medicine ,Molecular Biology ,Pathology and Forensic Medicine - Abstract
The first section of the bone marrow workshop of the European Association of Haematopathology (EAHP) 2020 Virtual Meeting was dedicated to pediatric myeloid neoplasms. The section covered the whole spectrum of myeloid neoplasms, including myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), myelodysplastic/myeloproliferative neoplasms (MDS/MPN), and acute myeloid leukemia (AML). The workshop cases are hereby presented, preceded by an introduction on these overall rare diseases in this age group. Very rare entities such as primary myelofibrosis, pediatric MDS with fibrosis, and MDS/MPN with JMML-like features and t(4;17)(q12;q21); FIP1L1::RARA fusion, are described in more detail.
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- 2022
10. NRF2 and STAT3: friends or foes in carcinogenesis?
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Arena, Andrea, primary, Romeo, Maria Anele, additional, Benedetti, Rossella, additional, Gilardini Montani, Maria Saveria, additional, Santarelli, Roberta, additional, Gonnella, Roberta, additional, D’Orazi, Gabriella, additional, and Cirone, Mara, additional
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- 2023
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11. NRF2 and STAT3: friends or foes in carcinogenesis?
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Andrea Arena, Maria Anele Romeo, Rossella Benedetti, Maria Saveria Gilardini Montani, Roberta Santarelli, Roberta Gonnella, Gabriella D’Orazi, and Mara Cirone
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Cancer Research ,Endocrinology ,Oncology ,Endocrine and Autonomic Systems ,Endocrinology, Diabetes and Metabolism - Abstract
NRF2 is a transcription factor that plays a pivotal role in carcinogenesis, also through the interaction with several pro-survival pathways. NRF2 controls the transcription of detoxification enzymes and a variety of other molecules impinging in several key biological processes. This perspective will focus on the complex interplay of NRF2 with STAT3, another transcription factor often aberrantly activated in cancer and driving tumorigenesis as well as immune suppression. Both NRF2 and STAT3 can be regulated by ER stress/UPR activation and their cross-talk influences and is influenced by autophagy and cytokines, contributing to shape the microenvironment, and both control the execution of DDR, also by regulating the expression of HSPs. Given the importance of these transcription factors, more investigations aimed at better elucidating the outcome of their networking could help to discover new and more efficacious strategies to fight cancer.
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- 2023
12. Effects of Ti6Al4V mechanical and thermal surface modification on the adhesion of a chitosan-bioactive glass coating
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Sanguedolce, Michela, primary, Rotella, Giovanna, additional, Curcio, Federica, additional, Pelaccia, Riccardo, additional, Siciliani, Vincenzina, additional, Cassano, Roberta, additional, Orazi, Leonardo, additional, and Filice, Luigino, additional
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- 2023
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13. Non-face emojis in digital marketing: Effects, contingencies, and strategic recommendations
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Orazi, Davide Christian, primary, Ranjan, Bhoomija, additional, and Cheng, Yimin, additional
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- 2023
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14. International Consensus Classification of myeloid and lymphoid neoplasms: myeloproliferative neoplasms
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Gianelli, Umberto, primary, Thiele, Jürgen, additional, Orazi, Attilio, additional, Gangat, Naseema, additional, Vannucchi, Alessandro M., additional, Tefferi, Ayalew, additional, and Kvasnicka, Hans Michael, additional
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- 2022
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15. Photopyroelectric Investigation of the trans–cis Isomerization Effect on the Nematic- Isotropic Phase Transition of a Liquid Crystalline Azobenzene
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Paoloni, S., primary, Mercuri, F., additional, Zammit, U., additional, and Orazi, N., additional
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- 2022
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16. Advances in myelodysplastic/myeloproliferative neoplasms
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Prakash, Sonam, primary, Arber, Daniel A., additional, Bueso-Ramos, Carlos, additional, Hasserjian, Robert P., additional, and Orazi, Attilio, additional
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- 2022
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17. Rapid contraction of giant planets orbiting the 20-million-year-old star V1298 Tau
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A. Suárez Mascareño, M. Damasso, N. Lodieu, A. Sozzetti, V. J. S. Béjar, S. Benatti, M. R. Zapatero Osorio, G. Micela, R. Rebolo, S. Desidera, F. Murgas, R. Claudi, J. I. González Hernández, L. Malavolta, C. del Burgo, V. D’Orazi, P. J. Amado, D. Locci, H. M. Tabernero, F. Marzari, D. S. Aguado, D. Turrini, C. Cardona Guillén, B. Toledo-Padrón, A. Maggio, J. Aceituno, F. F. Bauer, J. A. Caballero, P. Chinchilla, E. Esparza-Borges, E. González-Álvarez, T. Granzer, R. Luque, E. L. Martín, G. Nowak, M. Oshagh, E. Pallé, H. Parviainen, A. Quirrenbach, A. Reiners, I. Ribas, K. G. Strassmeier, M. Weber, M. Mallonn, Ministerio de Ciencia e Innovación (España), and European Commission
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Earth and Planetary Astrophysics (astro-ph.EP) ,FOS: Physical sciences ,Astrophysics::Solar and Stellar Astrophysics ,Astronomy and Astrophysics ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics::Galaxy Astrophysics ,Astrophysics - Earth and Planetary Astrophysics - Abstract
Current theories of planetary evolution predict that infant giant planets have large radii and very low densities before they slowly contract to reach their final size after about several hundred million years1,2. These theoretical expectations remain untested so far as the detection and characterization of very young planets is extremely challenging due to the intense stellar activity of their host stars3,4. Only the recent discoveries of young planetary transiting systems allow initial constraints to be placed on evolutionary models5,6,7. With an estimated age of 20 million years, V1298 Tau is one of the youngest solar-type stars known to host transiting planets; it harbours a system composed of four planets, two Neptune-sized, one Saturn-sized and one Jupiter-sized8,9. Here we report a multi-instrument radial velocity campaign of V1298 Tau, which allowed us to determine the masses of two of the planets in the system. We find that the two outermost giant planets, V1298 Tau b and e (0.64 ± 0.19 and 1.16 ± 0.30 Jupiter masses, respectively), seem to contradict our knowledge of early-stages planetary evolution. According to models, they should reach their mass–radius combination only hundreds of millions of years after formation. This result suggests that giant planets can contract much more quickly than usually assumed. © 2021, The Author(s), under exclusive licence to Springer Nature Limited., A.S.M. acknowledges financial support from the Spanish Ministry of Science and Innovation (MICINN) under the 2019 Juan de la Cierva Programme. J.I.G.H. acknowledges financial support from the Spanish MICINN under the 2013 Ramón y Cajal programme RYC-2013-14875. A.S.M., J.I.G.H., R.R., B.T.-P., N.L., M.R.Z.O., E.G.-A., J.A.C., P.J.A. and I.R. acknowledge financial support from the Spanish Ministry of Science and Innovation through projects AYA2017-86389-P, PID2019-109522GB-C53, PID2019-109522GB-C51, AYA2016-79425-C3-3-P, PID2019-109522GB-C52 and PGC2018-098153-B-C33. M.D. acknowledges financial support from the FP7-SPACE Project ETAEARTH (GA no. 313014). A.M., D.L., G.M., A.S. and S.D. acknowledge partial contribution from the agreement ASI-INAF no. 2018-16-HH.0. S.B., D.L., G.M. and D.T. acknowledge partial contribution from the agreement ASI-INAF no. 2021-5-HH.0. P.J.A. acknowledges financial support from the project SEV-2017-0709. S.D., V.D., S.B. and D.T. acknowledge support from the PRIN-INAF 2019 ‘Planetary systems at young ages’ (PLATEA). D.S.A. thanks the Leverhulme Trust for financial support. I.R. acknowledges the support of the Generalitat de Catalunya/CERCA programme. E.G.-A acknowledges support from the Spanish State Research Agency (AEI) project no. MDM-2017-0737 Unidad de Excelencia ‘María de Maeztu’ Centro de Astrobiología (CAB, CSIC/INTA). D.T. acknowledges the support of the Italian National Institute of Astrophysics (INAF) through the INAF Main Stream project ‘Ariel and the astrochemical link between circumstellar discs and planets’ (CUP: C54I19000700005). E.E.-B. acknowledges financial support from the European Union and the State Agency of Investigation of the Spanish Ministry of Science and Innovation (MICINN) under grant PRE2020-093107 of the Pre-Doc Program for the Training of Doctors (FPI-SO) through FEDER, FSE and FDCAN funds. This work is based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated by the Fundación Galileo Galilei (FGG) of the Istituto Nazionale di Astrofisica (INAF) at the Observatorio del Roque de los Muchachos (La Palma, Canary Islands, Spain). CARMENES is an instrument at the Centro Astronómico Hispano-Alemán (CAHA) at Calar Alto (Almería, Spain), operated jointly by the Junta de Andalucía and the Instituto de Astrofísica de Andalucía (CSIC). This work is based on data obtained with the STELLA robotic telescopes in Tenerife, an AIP facility jointly operated by AIP and IAC. This work makes use of observations from the LCOGT network.
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- 2021
18. Cellular anatomy of the mouse primary motor cortex
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Judith Mizrachi, Partha P. Mitra, Arun Narasimhan, Philip R. Nicovich, Sarojini M. Attili, Hideki Kondo, Pavel Osten, Muye Zhu, Brian Zingg, Anthony M. Zador, Stephan Fischer, William Galbavy, Uree Chon, Liya Ding, Stephanie Mok, Kwanghun Chung, Florence D’Orazi, Xu An, Shenqin Yao, Philip Lesnar, Wayne Wakemen, James C. Gee, Darrick Lo, Kathleen Kelly, Ian Bowman, Lydia Ng, Peng Xie, Quanxin Wang, Karla E. Hirokawa, X. William Yang, Julie A. Harris, Xiuli Kuang, Huizhong W. Tao, Samik Bannerjee, Elise Shen, Xu Li, Z. Josh Huang, Ali Cetin, Young Gyun Park, Lijuan Liu, Corey Elowsky, Xiangning Li, Lin Gou, Hong-Wei Dong, Laura Korobkova, Joshua T. Hatfield, Junxiang Jason Huang, Hui Gong, Yun Wang, Houri Hintiryan, Nicholas N. Foster, Peter A. Groblewski, Michael S. Bienkowski, Diek W. Wheeler, Xiaoyin Chen, Yu-Chi Sun, Anastasiia Bludova, Maitham Naeemi, Rodrigo Muñoz-Castañeda, Joel D. Hahn, Jing Yuan, Hanchuan Peng, Katherine Matho, Jason Palmer, Huiqing Zhan, Yimin Wang, Hongkui Zeng, Michael Hawrylycz, Chris Sin Park, Li I. Zhang, Rhonda Drewes, Ramesh Palaniswamy, Bing-Xing Huo, Anan Li, Yongsoo Kim, Jesse Gillis, Byung Kook Lim, Lei Gao, Giorgio A. Ascoli, Xiaoli Qi, Meng Kuan Lin, Yaoyao Li, and Qingming Luo
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Male ,Computer science ,Neuroimaging ,Neural circuits ,Article ,Mice ,Atlases as Topic ,Glutamates ,medicine ,Biological neural network ,Animals ,GABAergic Neurons ,Neurons ,Multidisciplinary ,Sequence Analysis, RNA ,Brain atlas ,Motor Cortex ,Motor control ,Neuroinformatics ,Cellular Anatomy ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Cellular resolution ,Organ Specificity ,Female ,Single-Cell Analysis ,Primary motor cortex ,Neuroscience ,Motor cortex - Abstract
An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted1. Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input–output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture., Multi-modal analysis is used to generate a 3D atlas of the upper limb area of the mouse primary motor cortex, providing a framework for future studies of motor control circuitry.
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- 2021
19. Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases
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Reichard, Kaaren K., primary, Tefferi, Ayalew, additional, Abdelmagid, Maymona, additional, Orazi, Attilio, additional, Alexandres, Christina, additional, Haack, Joanna, additional, and Greipp, Patricia T., additional
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- 2022
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20. Strategic Asset Allocation of a Reserves’ Portfolio: Hedging Against Shocks
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Torriani, Mario L., primary, Orazi, Pablo, additional, and Vicens, Matias, additional
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- 2022
- Full Text
- View/download PDF
21. The International Consensus Classification of myelodysplastic syndromes and related entities
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Hasserjian, Robert P., primary, Orazi, Attilio, additional, Orfao, Alberto, additional, Rozman, Maria, additional, and Wang, Sa A., additional
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- 2022
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22. Classification of rare pediatric myeloid neoplasia—Quo vadis?
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Niemeyer, Charlotte M., primary, Rudelius, Martina, additional, Shimamura, Akiko, additional, Flotho, Christian, additional, Hasle, Henrik, additional, Stieglitz, Elliot, additional, Strahm, Brigitte, additional, Godley, Lucy A., additional, Weinberg, Olga K., additional, Orazi, Attilio, additional, and Calvo, Katherine R., additional
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- 2022
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23. The International Consensus Classification of acute myeloid leukemia
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Weinberg, Olga K., primary, Porwit, Anna, additional, Orazi, Attilio, additional, Hasserjian, Robert P., additional, Foucar, Kathryn, additional, Duncavage, Eric J., additional, and Arber, Daniel A., additional
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- 2022
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24. The international consensus classification of mastocytosis and related entities
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Leguit, Roos J., primary, Wang, Sa A., additional, George, Tracy I., additional, Tzankov, Alexandar, additional, and Orazi, Attilio, additional
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- 2022
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25. Updates on eosinophilic disorders
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Tzankov, Alexandar, primary, Reichard, Kaaren K., additional, Hasserjian, Robert P., additional, Arber, Daniel A., additional, Orazi, Attilio, additional, and Wang, Sa A., additional
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- 2022
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26. Response to “The WHO classification of haematolymphoid tumours” (Editorial)
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Swerdlow, Steven H., primary, Campo, Elias, additional, Arber, Daniel A., additional, Cazzola, Mario, additional, Cook, James R., additional, Döhner, Hartmut, additional, Dreyling, Martin, additional, Hasserjian, Robert P., additional, Jaffe, Elaine S., additional, Orazi, Attilio, additional, Quintanilla-Martinez, Leticia, additional, Scott, David W., additional, Tefferi, Ayalew, additional, Winter, Jane N., additional, and Zelenetz, Andrew D., additional
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- 2022
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27. EAHP 2020 workshop proceedings, pediatric myeloid neoplasms
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Leguit, R. J., primary, Orazi, A., additional, Kucine, N., additional, Kvasnicka, H. M., additional, Gianelli, U., additional, Arber, D. A., additional, Porwit, A., additional, and Ponzoni, M., additional
- Published
- 2022
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28. ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress
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Benedetti, Rossella, primary, Romeo, Maria Anele, additional, Arena, Andrea, additional, Gilardini Montani, Maria Saveria, additional, Di Renzo, Livia, additional, D’Orazi, Gabriella, additional, and Cirone, Mara, additional
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- 2022
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29. Astronomy organizations should lead in our battle against the climate crisis
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Burtscher, Leo, primary, Balaguer-Núñez, Lola, additional, D’Orazi, Valentina, additional, Barret, Didier, additional, Beuchert, Tobias, additional, Dil, Emre, additional, Janiuk, Agnieszka, additional, Mingo, Beatriz, additional, and Poggio, Eloisa, additional
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- 2022
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30. Early angiographic signs of retinopathy of prematurity requiring treatment
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Lepore, Domenico, Marco H, Ji, Ying, Gui-Shuang, Orazi, Lorenzo, Pagliara, Monica M, Quinn, Graham E, FA team of the Italian ROP study Group, Antonio, Baldascino, Velia, Porcaro, Patrizia, Papacci, Giovanni, Vento, Gusson, Elena, Marchini, Giorgio, Silvia, Pignatto, Paolo, Lanzetta, Elena, Piozzi, Marco, Mazza, Giovanni, Marsico, Giuseppina, Fortunato, Roberto, Caputo, and Fernando, Molle
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medicine.medical_specialty ,genetic structures ,Angiogenesis Inhibitors ,Fundus (eye) ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Intensive care ,Ophthalmology ,medicine ,Humans ,Retinopathy of Prematurity ,Retrospective Studies ,Retina ,medicine.diagnostic_test ,business.industry ,Infant, Newborn ,Postmenstrual Age ,Infant ,Retrospective cohort study ,Retinal ,Retinopathy of prematurity ,Newborn ,Fluorescein angiography ,medicine.disease ,eye diseases ,Bevacizumab ,medicine.anatomical_structure ,chemistry ,Intravitreal Injections ,030221 ophthalmology & optometry ,sense organs ,business ,030217 neurology & neurosurgery - Abstract
BACKGROUND/OBJECTIVES: Fluorescein angiography (FA) has been a pivotal tool to study the pathophysiology of retinopathy of prematurity (ROP) in vivo. We examined the course of ROP using FA in order to assess the predictive value of angiographic features. SUBJECTS/METHODS: This is an observational retrospective cohort multi-center study of eyes screened for ROP with binocular indirect ophthalmoscope and with FA. All infants undergoing screening examination for ROP who had retinal vasculature limited to Zone I and posterior Zone II vascularization underwent FA between 31 and 34 weeks postmenstrual age. RetCam fundus imaging and video digital fluorescein angiography were performed in the neonatal intensive care units. Masked grading of the FA images was retrospectively conducted by two ROP expert ophthalmologists. Ten criteria that describe retinovascular and choroidal features on FA were used to assess their predictive value for development of treatment-requiring ROP. RESULTS: A total of 98 eyes of 56 patients were included for this study. FAs of eyes of premature infants show a wide range of features either at the junction between the vascular and avascular retina and posteriorly to that. Among the angiographic features evaluated, leakage, shunts and hyperfluorescent lesions at the junction between vascular and avascular zone were predictive of the development of treatment-requiring ROP (p
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- 2021
31. KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
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Luca Falcinelli, Maria Anele Romeo, Maria Saveria Gilardini Montani, Gabriella D'Orazi, Roberta Gonnella, Nives Cecere, Mara Cirone, Roberta Santarelli, Marisa Granato, and Alberto Faggioni
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Cancer microenvironment ,STAT3 Transcription Factor ,Transcriptional Activation ,Vascular Endothelial Growth Factor A ,X-Box Binding Protein 1 ,Cancer Research ,XBP1 ,Carcinogenesis ,viruses ,medicine.medical_treatment ,Protein Serine-Threonine Kinases ,Biology ,Virus Replication ,medicine.disease_cause ,Article ,B7-H1 Antigen ,Stress signalling ,Viral Proteins ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Endoribonucleases ,medicine ,Humans ,Macrophage ,kshv ,macrophage polarization ,cytokine release ,upr ,STAT3 ,Sarcoma, Kaposi ,030304 developmental biology ,STAT6 ,0303 health sciences ,Interleukin-6 ,Macrophages ,Interleukin-8 ,virus diseases ,Macrophage Activation ,Interleukin-10 ,Gene Expression Regulation, Neoplastic ,Cytokine ,Oncology ,030220 oncology & carcinogenesis ,Herpesvirus 8, Human ,biology.protein ,Cancer research ,STAT6 Transcription Factor ,CD163 ,Signal Transduction - Abstract
BackgroundKaposi’s Sarcoma Herpesvirus (KSHV) is a gammaherpesvirus strongly linked to human cancer. The virus is also able to induce immune suppression, effect that contributes to onset/progression of the viral-associated malignancies. As KSHV may infect macrophages and these cells abundantly infiltrate Kaposi’s sarcoma lesions, in this study we investigated whether KSHV-infection could affect macrophage polarisation to promote tumorigenesis.MethodsFACS analysis was used to detect macrophage markers and PD-L1 expression. KSHV infection and the molecular pathways activated were investigated by western blot analysis and by qRT-PCR while cytokine release was assessed by Multi-analyte Kit.ResultsWe found that KSHV infection reduced macrophage survival and skewed their polarisation towards M2 like/TAM cells, based on the expression of CD163, on the activation of STAT3 and STAT6 pathways and the release of pro-tumorigenic cytokines such as IL-10, VEGF, IL-6 and IL-8. We also found that KSHV triggered Ire1 α-XBP1 axis activation in infected macrophages to increase the release of pro-tumorigenic cytokines and to up-regulate PD-L1 surface expression.ConclusionsThe findings that KSHV infection of macrophages skews their polarisation towards M2/TAM and that activate Ire1 α-XBP1 to increase the release of pro-tumorigenic cytokines and the expression of PD-L1, suggest that manipulation of UPR could be exploited to prevent or improve the treatment of KSHV-associated malignancies.
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- 2020
32. Generation and Characterization of Laser Induced Periodic Surface Structures on Plastic Injection Molds
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Leonardo Orazi, Leonardo Piccolo, Giovanni Lucchetta, Davide Masato, and Marco Sorgato
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Injection molding ,Wall slip ,Nuclear and High Energy Physics ,Work (thermodynamics) ,Materials science ,Flow (psychology) ,Laser micro machining ,technology, industry, and agriculture ,Molding (process) ,Laser ,medicine.disease_cause ,Industrial and Manufacturing Engineering ,law.invention ,Characterization (materials science) ,law ,Modeling and Simulation ,Mold ,medicine ,Surface modification ,Composite material ,Instrumentation ,Slipping - Abstract
In injection molding, high pressure is required to fill the mold, due to the high viscosity of thermoplastic polymers, the reduced thickness of the cavity and the low mold temperature. In this work, we investigate the functionalization of mold cavities for Injection Molding by means of Laser-Induced Periodic Surface Structures (LIPSS) generated on the ground surface of AISI 420 stainless steel through a picosecond laser. The LIPSS formation is examined with reference to the process parameters, highlighting how they affect the generated pattern. The improvements of the functionalized mold surface on the Injection Molding process are experimentally characterized and discussed. In particular, the slipping of molten PET was investigated as a function of nano-structuring orientation and injection velocity. The results demonstrate that LIPSS parallel to flow induce strong wall slip of the polymer melt, allowing a maximum reduction of the injection pressure of 10%.
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- 2020
33. Modeling and analysis of the visualized gas-assisted laser cutting flow from both conical and supersonic nozzles
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Leonardo Orazi, Mohamed Darwish, Libor Mrňa, and Barbara Reggiani
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0209 industrial biotechnology ,Jet (fluid) ,Materials science ,Laser cutting ,Mechanical Engineering ,Nozzle ,02 engineering and technology ,Conical surface ,Mechanics ,Industrial and Manufacturing Engineering ,Computer Science Applications ,Cut kerf ,Gas-assisted laser cutting ,OpenFOAM ,Schlieren visualization ,Stand-off distance ,Supersonic nozzles ,Physics::Fluid Dynamics ,020901 industrial engineering & automation ,Electrical discharge machining ,Control and Systems Engineering ,Schlieren ,Physics::Atomic and Molecular Clusters ,Supersonic speed ,Coaxial ,Software - Abstract
A coaxial high-pressure gas jet is normally used to assist and enhance laser cutting quality and capability. However, the gas nozzles are mostly of conical type causing the deterioration of the dynamic characteristics of the exit jet. In this research, the effect of both nozzle type and nozzle dimensions on the uniformity and behavior of the exit jet has been investigated. A total of three different supersonic nozzles have been designed in accordance to gas dynamics theory and manufactured using wire electrical discharge machining (WEDM). The exit jet patterns from these supersonic nozzles and a reference conical nozzle have been numerically modeled and compared with the experimental observations made through Schlieren visualization. The experimental results are found to match and hence validate the simulations. It is concluded that the exit jet from the supersonic nozzle is marked by uniformity, better dynamic characteristics, and longer effective exit jet length compared with conical nozzle.
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- 2020
34. Correction to: Effect of X-ray and artificial aging on parchment
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Monia Vadrucci, Cristina Cicero, Claudia Mazzuca, Fulvio Mercuri, Mauro Missori, Noemi Orazi, Leonardo Severini, and Ugo Zammit
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General Physics and Astronomy - Published
- 2022
35. Response to 'The WHO classification of haematolymphoid tumours' (Editorial)
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Steven H. Swerdlow, Elias Campo, Daniel A. Arber, Mario Cazzola, James R. Cook, Hartmut Döhner, Martin Dreyling, Robert P. Hasserjian, Elaine S. Jaffe, Attilio Orazi, Leticia Quintanilla-Martinez, David W. Scott, Ayalew Tefferi, Jane N. Winter, and Andrew D. Zelenetz
- Subjects
Cancer Research ,Oncology ,Hematology - Published
- 2022
36. Correction to: Effect of X-ray and artificial aging on parchment
- Author
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Vadrucci, Monia, primary, Cicero, Cristina, additional, Mazzuca, Claudia, additional, Mercuri, Fulvio, additional, Missori, Mauro, additional, Orazi, Noemi, additional, Severini, Leonardo, additional, and Zammit, Ugo, additional
- Published
- 2022
- Full Text
- View/download PDF
37. Correction to: Short‑ and mid‑term multidisciplinary outcomes of newborns exposed to SARS‑CoV‑2 in utero or during the perinatal period: preliminary findings
- Author
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Buonsenso, Danilo, primary, Costa, Simonetta, additional, Giordano, Lucia, additional, Priolo, Francessca, additional, Colonna, Arianna Turriziani, additional, Morini, Sofia, additional, Sbarbati, Martina, additional, Pata, Davide, additional, Acampora, Anna, additional, Conti, Guido, additional, Crudo, Fabrizio, additional, Cantiani, Alessandro, additional, Martina, Bianca Maria, additional, Amorelli, Giulia Maria, additional, Orazi, Lorenzo, additional, Petrianni, Maria, additional, Ricci, Daniela, additional, Lanzone, Antonio, additional, Sanguinetti, Maurizio, additional, Cattani, Paola, additional, Sali, Michela, additional, Romeo, Domenico, additional, Zampino, Giuseppe, additional, Vento, Giovanni, additional, and Valentini, Piero, additional
- Published
- 2022
- Full Text
- View/download PDF
38. The role of retinal imaging in the management of abusive head trauma cases
- Author
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Oliva, Antonio, primary, Grassi, Simone, additional, Cazzato, Francesca, additional, Jabbehdari, Sayena, additional, Mensi, Lorenzo, additional, Amorelli, Giulia, additional, Orazi, Lorenzo, additional, Arena, Vincenzo, additional, and Lepore, Domenico, additional
- Published
- 2022
- Full Text
- View/download PDF
39. Short- and mid-term multidisciplinary outcomes of newborns exposed to SARS-CoV-2 in utero or during the perinatal period: preliminary findings
- Author
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Buonsenso, Danilo, primary, Costa, Simonetta, additional, Giordano, Lucia, additional, Priolo, Francessca, additional, Colonna, Arianna Turriziani, additional, Morini, Sofia, additional, Sbarbati, Martina, additional, Pata, Davide, additional, Acampora, Anna, additional, Conti, Guido, additional, Crudo, Fabrizio, additional, Cantiani, Alessandro, additional, Martina, Bianca Maria, additional, Amorelli, Giulia Maria, additional, Orazi, Lorenzo, additional, Petrianni, Maria, additional, Ricci, Daniela, additional, Lanzone, Antonio, additional, Sanguinetti, Maurizio, additional, Cattani, Paola, additional, Sali, Michela, additional, Romeo, Domenico, additional, Zampino, Giuseppe, additional, Vento, Giovanni, additional, and Valentini, Piero, additional
- Published
- 2022
- Full Text
- View/download PDF
40. Author Correction: Human neocortical expansion involves glutamatergic neuron diversification
- Author
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Berg, Jim, primary, Sorensen, Staci A., additional, Ting, Jonathan T., additional, Miller, Jeremy A., additional, Chartrand, Thomas, additional, Buchin, Anatoly, additional, Bakken, Trygve E., additional, Budzillo, Agata, additional, Dee, Nick, additional, Ding, Song-Lin, additional, Gouwens, Nathan W., additional, Hodge, Rebecca D., additional, Kalmbach, Brian, additional, Lee, Changkyu, additional, Lee, Brian R., additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Barkan, Eliza, additional, Beller, Allison, additional, Berry, Kyla, additional, Bertagnolli, Darren, additional, Bickley, Kris, additional, Bomben, Jasmine, additional, Braun, Thomas, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Chong, Peter, additional, Crichton, Kirsten, additional, Dalley, Rachel, additional, de Frates, Rebecca, additional, Desta, Tsega, additional, Lee, Samuel Dingman, additional, D’Orazi, Florence, additional, Dotson, Nadezhda, additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Farrell, Colin, additional, Feng, David, additional, Fong, Olivia, additional, Furdan, Szabina, additional, Galakhova, Anna A., additional, Gamlin, Clare, additional, Gary, Amanda, additional, Glandon, Alexandra, additional, Goldy, Jeff, additional, Gorham, Melissa, additional, Goriounova, Natalia A., additional, Gratiy, Sergey, additional, Graybuck, Lucas, additional, Gu, Hong, additional, Hadley, Kristen, additional, Hansen, Nathan, additional, Heistek, Tim S., additional, Henry, Alex M., additional, Heyer, Djai B., additional, Hill, DiJon, additional, Hill, Chris, additional, Hupp, Madie, additional, Jarsky, Tim, additional, Kebede, Sara, additional, Keene, Lisa, additional, Kim, Lisa, additional, Kim, Mean-Hwan, additional, Kroll, Matthew, additional, Latimer, Caitlin, additional, Levi, Boaz P., additional, Link, Katherine E., additional, Mallory, Matthew, additional, Mann, Rusty, additional, Marshall, Desiree, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica, additional, Mertens, Eline J., additional, Mezei, Leona, additional, Mihut, Norbert, additional, Mok, Stephanie, additional, Molnar, Gabor, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Ngo, Kiet, additional, Nicovich, Philip R., additional, Nyhus, Julie, additional, Olah, Gaspar, additional, Oldre, Aaron, additional, Omstead, Victoria, additional, Ozsvar, Attila, additional, Park, Daniel, additional, Peng, Hanchuan, additional, Pham, Trangthanh, additional, Pom, Christina A., additional, Potekhina, Lydia, additional, Rajanbabu, Ramkumar, additional, Ransford, Shea, additional, Reid, David, additional, Rimorin, Christine, additional, Ruiz, Augustin, additional, Sandman, David, additional, Sulc, Josef, additional, Sunkin, Susan M., additional, Szafer, Aaron, additional, Szemenyei, Viktor, additional, Thomsen, Elliot R., additional, Tieu, Michael, additional, Torkelson, Amy, additional, Trinh, Jessica, additional, Tung, Herman, additional, Wakeman, Wayne, additional, Waleboer, Femke, additional, Ward, Katelyn, additional, Wilbers, René, additional, Williams, Grace, additional, Yao, Zizhen, additional, Yoon, Jae-Geun, additional, Anastassiou, Costas, additional, Arkhipov, Anton, additional, Barzo, Pal, additional, Bernard, Amy, additional, Cobbs, Charles, additional, de Witt Hamer, Philip C., additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gwinn, Ryder P., additional, Hawrylycz, Michael J., additional, Hof, Patrick R., additional, Idema, Sander, additional, Jones, Allan R., additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Murphy, Gabe J., additional, Ng, Lydia, additional, Ojemann, Jeffrey G., additional, Patel, Anoop P., additional, Phillips, John W., additional, Silbergeld, Daniel L., additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Yuste, Rafael, additional, Segev, Idan, additional, de Kock, Christiaan P. J., additional, Mansvelder, Huibert D., additional, Tamas, Gabor, additional, Zeng, Hongkui, additional, Koch, Christof, additional, and Lein, Ed S., additional
- Published
- 2022
- Full Text
- View/download PDF
41. Rapid contraction of giant planets orbiting the 20-million-year-old star V1298 Tau
- Author
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Suárez Mascareño, A., primary, Damasso, M., additional, Lodieu, N., additional, Sozzetti, A., additional, Béjar, V. J. S., additional, Benatti, S., additional, Zapatero Osorio, M. R., additional, Micela, G., additional, Rebolo, R., additional, Desidera, S., additional, Murgas, F., additional, Claudi, R., additional, González Hernández, J. I., additional, Malavolta, L., additional, del Burgo, C., additional, D’Orazi, V., additional, Amado, P. J., additional, Locci, D., additional, Tabernero, H. M., additional, Marzari, F., additional, Aguado, D. S., additional, Turrini, D., additional, Cardona Guillén, C., additional, Toledo-Padrón, B., additional, Maggio, A., additional, Aceituno, J., additional, Bauer, F. F., additional, Caballero, J. A., additional, Chinchilla, P., additional, Esparza-Borges, E., additional, González-Álvarez, E., additional, Granzer, T., additional, Luque, R., additional, Martín, E. L., additional, Nowak, G., additional, Oshagh, M., additional, Pallé, E., additional, Parviainen, H., additional, Quirrenbach, A., additional, Reiners, A., additional, Ribas, I., additional, Strassmeier, K. G., additional, Weber, M., additional, and Mallonn, M., additional
- Published
- 2021
- Full Text
- View/download PDF
42. Effect of X-ray and artificial aging on parchment
- Author
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Orazi Noemi, Mazzuca Claudia, Cicero Cristina, Vadrucci Monia, Severini Leonardo, Mercuri Fulvio, Zammit Ugo, Missori Mauro, Vadrucci, M., Cristina, C., Claudia, M., Fulvio, M., Mauro, M., Noemi, O., Leonardo, S., and Ugo, Z.
- Subjects
Settore FIS/01 ,spectroscopy ,Light transmission ,Materials science ,parchment ,Parchment ,X-ray ,General Physics and Astronomy ,Artificial aging ,Reflectivity ,COLLAGEN ,Settore CHIM/02 ,LTA ,deterioration ,PAPER ,Irradiation ,Fourier transform infrared spectroscopy ,Composite material - Abstract
In this study, the employment of the X-ray irradiation as bioremediation method to treat parchment has been deeply investigated. In particular, the effect of the irradiation doses on the structural stability of collagen, the main constituent of parchment, has been evaluated on a series of modern parchment samples by means of different opto-thermal and spectroscopic techniques in order to obtain the dose-dependent effect of irradiation on collagen. Moreover, the long-term behavior of the irradiated parchment has been considered by analyzing the same series of samples after being hygrothermally artificially aged. Characterizations by light transmission analysis, Fourier transform infrared spectroscopy and the ultraviolet–visible–near infrared (UV–Vis–NIR) reflectance one have been performed for the identification of the radio-induced effect on the parchment structure even in a dose range much wider than the need for sterilization. The obtained results have proved the safeness of the method in the short and long term confirming the applicability of this emerging procedure.
- Published
- 2021
43. Detecting life outside our solar system with a large high-contrast-imaging mission
- Author
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Snellen, Ignas A. G., primary, Snik, F., additional, Kenworthy, M., additional, Albrecht, S., additional, Anglada-Escudé, G., additional, Baraffe, I., additional, Baudoz, P., additional, Benz, W., additional, Beuzit, J.-L., additional, Biller, B., additional, Birkby, J. L., additional, Boccaletti, A., additional, van Boekel, R., additional, de Boer, J., additional, Brogi, Matteo, additional, Buchhave, L., additional, Carone, L., additional, Claire, M., additional, Claudi, R., additional, Demory, B.-O., additional, Désert, J.-M., additional, Desidera, S., additional, Gaudi, B. S., additional, Gratton, R., additional, Gillon, M., additional, Grenfell, J. L., additional, Guyon, O., additional, Henning, T., additional, Hinkley, S., additional, Huby, E., additional, Janson, M., additional, Helling, C., additional, Heng, K., additional, Kasper, M., additional, Keller, C. U., additional, Krause, O., additional, Kreidberg, L., additional, Madhusudhan, N., additional, Lagrange, A.-M., additional, Launhardt, R., additional, Lenton, T. M., additional, Lopez-Puertas, M., additional, Maire, A.-L., additional, Mayne, N., additional, Meadows, V., additional, Mennesson, B., additional, Micela, G., additional, Miguel, Y., additional, Milli, J., additional, Min, M., additional, de Mooij, E., additional, Mouillet, D., additional, N’Diaye, M., additional, D’Orazi, V., additional, Palle, E., additional, Pagano, I., additional, Piotto, G., additional, Queloz, D., additional, Rauer, H., additional, Ribas, I., additional, Ruane, G., additional, Selsis, F., additional, Sozzetti, A., additional, Stam, D., additional, Stark, C.C., additional, Vigan, A., additional, and de Visser, Pieter, additional
- Published
- 2021
- Full Text
- View/download PDF
44. Human neocortical expansion involves glutamatergic neuron diversification
- Author
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Berg, Jim, primary, Sorensen, Staci A., additional, Ting, Jonathan T., additional, Miller, Jeremy A., additional, Chartrand, Thomas, additional, Buchin, Anatoly, additional, Bakken, Trygve E., additional, Budzillo, Agata, additional, Dee, Nick, additional, Ding, Song-Lin, additional, Gouwens, Nathan W., additional, Hodge, Rebecca D., additional, Kalmbach, Brian, additional, Lee, Changkyu, additional, Lee, Brian R., additional, Alfiler, Lauren, additional, Baker, Katherine, additional, Barkan, Eliza, additional, Beller, Allison, additional, Berry, Kyla, additional, Bertagnolli, Darren, additional, Bickley, Kris, additional, Bomben, Jasmine, additional, Braun, Thomas, additional, Brouner, Krissy, additional, Casper, Tamara, additional, Chong, Peter, additional, Crichton, Kirsten, additional, Dalley, Rachel, additional, de Frates, Rebecca, additional, Desta, Tsega, additional, Lee, Samuel Dingman, additional, D’Orazi, Florence, additional, Dotson, Nadezhda, additional, Egdorf, Tom, additional, Enstrom, Rachel, additional, Farrell, Colin, additional, Feng, David, additional, Fong, Olivia, additional, Furdan, Szabina, additional, Galakhova, Anna A., additional, Gamlin, Clare, additional, Gary, Amanda, additional, Glandon, Alexandra, additional, Goldy, Jeff, additional, Gorham, Melissa, additional, Goriounova, Natalia A., additional, Gratiy, Sergey, additional, Graybuck, Lucas, additional, Gu, Hong, additional, Hadley, Kristen, additional, Hansen, Nathan, additional, Heistek, Tim S., additional, Henry, Alex M., additional, Heyer, Djai B., additional, Hill, DiJon, additional, Hill, Chris, additional, Hupp, Madie, additional, Jarsky, Tim, additional, Kebede, Sara, additional, Keene, Lisa, additional, Kim, Lisa, additional, Kim, Mean-Hwan, additional, Kroll, Matthew, additional, Latimer, Caitlin, additional, Levi, Boaz P., additional, Link, Katherine E., additional, Mallory, Matthew, additional, Mann, Rusty, additional, Marshall, Desiree, additional, Maxwell, Michelle, additional, McGraw, Medea, additional, McMillen, Delissa, additional, Melief, Erica, additional, Mertens, Eline J., additional, Mezei, Leona, additional, Mihut, Norbert, additional, Mok, Stephanie, additional, Molnar, Gabor, additional, Mukora, Alice, additional, Ng, Lindsay, additional, Ngo, Kiet, additional, Nicovich, Philip R., additional, Nyhus, Julie, additional, Olah, Gaspar, additional, Oldre, Aaron, additional, Omstead, Victoria, additional, Ozsvar, Attila, additional, Park, Daniel, additional, Peng, Hanchuan, additional, Pham, Trangthanh, additional, Pom, Christina A., additional, Potekhina, Lydia, additional, Rajanbabu, Ramkumar, additional, Ransford, Shea, additional, Reid, David, additional, Rimorin, Christine, additional, Ruiz, Augustin, additional, Sandman, David, additional, Sulc, Josef, additional, Sunkin, Susan M., additional, Szafer, Aaron, additional, Szemenyei, Viktor, additional, Thomsen, Elliot R., additional, Tieu, Michael, additional, Torkelson, Amy, additional, Trinh, Jessica, additional, Tung, Herman, additional, Wakeman, Wayne, additional, Waleboer, Femke, additional, Ward, Katelyn, additional, Wilbers, René, additional, Williams, Grace, additional, Yao, Zizhen, additional, Yoon, Jae-Geun, additional, Anastassiou, Costas, additional, Arkhipov, Anton, additional, Barzo, Pal, additional, Bernard, Amy, additional, Cobbs, Charles, additional, de Witt Hamer, Philip C., additional, Ellenbogen, Richard G., additional, Esposito, Luke, additional, Ferreira, Manuel, additional, Gwinn, Ryder P., additional, Hawrylycz, Michael J., additional, Hof, Patrick R., additional, Idema, Sander, additional, Jones, Allan R., additional, Keene, C. Dirk, additional, Ko, Andrew L., additional, Murphy, Gabe J., additional, Ng, Lydia, additional, Ojemann, Jeffrey G., additional, Patel, Anoop P., additional, Phillips, John W., additional, Silbergeld, Daniel L., additional, Smith, Kimberly, additional, Tasic, Bosiljka, additional, Yuste, Rafael, additional, Segev, Idan, additional, de Kock, Christiaan P. J., additional, Mansvelder, Huibert D., additional, Tamas, Gabor, additional, Zeng, Hongkui, additional, Koch, Christof, additional, and Lein, Ed S., additional
- Published
- 2021
- Full Text
- View/download PDF
45. Cellular anatomy of the mouse primary motor cortex
- Author
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Muñoz-Castañeda, Rodrigo, primary, Zingg, Brian, additional, Matho, Katherine S., additional, Chen, Xiaoyin, additional, Wang, Quanxin, additional, Foster, Nicholas N., additional, Li, Anan, additional, Narasimhan, Arun, additional, Hirokawa, Karla E., additional, Huo, Bingxing, additional, Bannerjee, Samik, additional, Korobkova, Laura, additional, Park, Chris Sin, additional, Park, Young-Gyun, additional, Bienkowski, Michael S., additional, Chon, Uree, additional, Wheeler, Diek W., additional, Li, Xiangning, additional, Wang, Yun, additional, Naeemi, Maitham, additional, Xie, Peng, additional, Liu, Lijuan, additional, Kelly, Kathleen, additional, An, Xu, additional, Attili, Sarojini M., additional, Bowman, Ian, additional, Bludova, Anastasiia, additional, Cetin, Ali, additional, Ding, Liya, additional, Drewes, Rhonda, additional, D’Orazi, Florence, additional, Elowsky, Corey, additional, Fischer, Stephan, additional, Galbavy, William, additional, Gao, Lei, additional, Gillis, Jesse, additional, Groblewski, Peter A., additional, Gou, Lin, additional, Hahn, Joel D., additional, Hatfield, Joshua T., additional, Hintiryan, Houri, additional, Huang, Junxiang Jason, additional, Kondo, Hideki, additional, Kuang, Xiuli, additional, Lesnar, Philip, additional, Li, Xu, additional, Li, Yaoyao, additional, Lin, Mengkuan, additional, Lo, Darrick, additional, Mizrachi, Judith, additional, Mok, Stephanie, additional, Nicovich, Philip R., additional, Palaniswamy, Ramesh, additional, Palmer, Jason, additional, Qi, Xiaoli, additional, Shen, Elise, additional, Sun, Yu-Chi, additional, Tao, Huizhong W., additional, Wakemen, Wayne, additional, Wang, Yimin, additional, Yao, Shenqin, additional, Yuan, Jing, additional, Zhan, Huiqing, additional, Zhu, Muye, additional, Ng, Lydia, additional, Zhang, Li I., additional, Lim, Byung Kook, additional, Hawrylycz, Michael, additional, Gong, Hui, additional, Gee, James C., additional, Kim, Yongsoo, additional, Chung, Kwanghun, additional, Yang, X. William, additional, Peng, Hanchuan, additional, Luo, Qingming, additional, Mitra, Partha P., additional, Zador, Anthony M., additional, Zeng, Hongkui, additional, Ascoli, Giorgio A., additional, Josh Huang, Z., additional, Osten, Pavel, additional, Harris, Julie A., additional, and Dong, Hong-Wei, additional
- Published
- 2021
- Full Text
- View/download PDF
46. Correction to: Short‑ and mid‑term multidisciplinary outcomes of newborns exposed to SARS‑CoV‑2 in utero or during the perinatal period: preliminary findings
- Author
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Danilo Buonsenso, Simonetta Costa, Lucia Giordano, Francessca Priolo, Arianna Turriziani Colonna, Sofia Morini, Martina Sbarbati, Davide Pata, Anna Acampora, Guido Conti, Fabrizio Crudo, Alessandro Cantiani, Bianca Maria Martina, Giulia Maria Amorelli, Lorenzo Orazi, Maria Petrianni, Daniela Ricci, Antonio Lanzone, Maurizio Sanguinetti, Paola Cattani, Michela Sali, Domenico Romeo, Giuseppe Zampino, Giovanni Vento, and Piero Valentini
- Subjects
Pregnancy ,SARS-CoV-2 ,Pediatrics, Perinatology and Child Health ,Infant, Newborn ,Correction ,COVID-19 ,Humans ,Infant ,RNA, Viral ,Female ,Pregnancy Complications, Infectious ,Infectious Disease Transmission, Vertical - Abstract
The long-term outcomes of newborns exposed to SARS-CoV-2 infection in utero or during the first hours of life are still unknown. We performed a single-center, prospective, observational study of newborns born from mothers with microbiologically confirmed SARS-CoV-2 infection in pregnancy or at time of delivery. Infants were offered a multidisciplinary follow-up consisting of nasopharyngeal Polymerase Chain Reaction test at birth and at 48-72 h of life, auxological growth and neurological development, serologic testing, and audiological and ophthalmological assessments. One-hundred ninety-eight mothers and 199 newborns were enrolled. Of the 199 newborns, 171 underwent nasopharyngeal swab, four (2.3%) and two (1.15%) children tested positive at birth and 48-72 h of life, respectively. None had SARS-CoV-2 related symptoms. Auxologic and neurologic development were normal in all children during follow-up. Nine out of 59 infants had SARS-CoV-2 IgG at 3 months of life, which was associated with a positive nasopharyngeal swab at birth (P = 0.04). Twenty seven out of 143 (18.8%) newborns had pathologic transitory evoked otoacoustic emissions at birth, although 14/27 repeated after 1 month were normal. Audiological evaluation was completed with Auditory Brainstem Response between the third and sixth month of life in 34 children, showing in all normal hearing threshold. The ophthalmological evaluation found retinal vascular anomalies in 3/20 (15%) children, immature visual acuity in 5/20 (25%) children, and reduced distance attention in 6/20 cases (30%).Our study showed that the neonatal and mid-term multidisciplinary outcomes of newborns exposed to SARS-CoV-2 infection in utero or during the first hours of life are mostly positive, with the exception of ophthalmologic findings which, in a preliminary cohort, were abnormal in about 15% of cases. Further prospective, longitudinal studies are needed to better understand the clinical outcomes of children exposed to SARS-CoV-2 in utero and in the early postnatal life.• In utero mother-to-child transmission of SARS-CoV-2 has been documented by several independent studies. • Neonatal COVID-19 is a systemic disease that can be severe, although rarely.• Newborns exposed in utero to SARS-CoV-2 have mostly a normal auxological, audiological, and neurological development during the first months of life. • Fundus fluorescein angiography revealed that up to 5% of newborns exposed in utero to SARS-CoV2 can show retinal and choroidal abnormalities, including peripheral hypofluorescence of the choroid and increased vascular tortuosity.
- Published
- 2022
47. To Erect Temples to Virtue: Effects of State Mindfulness on Other-Focused Ethical Behaviors
- Author
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Davide C. Orazi, Eugene Y. Chan, and Jiemiao Chen
- Subjects
Economics and Econometrics ,Virtue ,Mindfulness ,media_common.quotation_subject ,05 social sciences ,06 humanities and the arts ,0603 philosophy, ethics and religion ,General Business, Management and Accounting ,Experimental research ,law.invention ,Arts and Humanities (miscellaneous) ,State (polity) ,law ,0502 economics and business ,CLARITY ,060301 applied ethics ,Meditation ,Business and International Management ,Business ethics ,Psychology ,Law ,Social psychology ,050203 business & management ,media_common ,Quality of Life Research - Abstract
While prior research suggests a link between mindfulness and ethical decision-making, most of the evidence for this link is correlational and refers to self-focused ethical behaviors. The paucity of experimental evidence, coupled with a lack of clarity on what mechanisms underlie the effect, limits our understanding of whether and how mindfulness might foster other-focused ethical behaviors. In this research, we hypothesize that state mindfulness might promote other-focused ethical behaviors by increasing resourcefulness, which we define as a perceived state of resource abundance. Across four experimental studies, we report causal evidence for the effects of state mindfulness instantiated through brief mindful meditation exercises on other-focused ethical behaviors, including choice of fair-trade products (Study 1A), charitable giving (Study 1B), and volunteering (Study 1C and Study 2). Resourcefulness mediates the effects of mindfulness on other-focused ethical behaviors (Study 2). Our work answers the call for more experimental research on mindfulness and its important implications for ethical decision-making.
- Published
- 2019
48. Simulation and analysis of the jet flow patterns from supersonic nozzles of laser cutting using OpenFOAM
- Author
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Leonardo Orazi, Diego Angeli, and Mohamed Darwish
- Subjects
0209 industrial biotechnology ,Materials science ,Laser cutting ,Nozzle ,Flow (psychology) ,Gas-assisted laser cutting ,OpenFOAM Ⓡ ,02 engineering and technology ,Computational fluid dynamics ,Compressible flow ,Over-expansion ,Supersonic nozzle ,Under-expansion ,Control and Systems Engineering ,Software ,Mechanical Engineering ,Computer Science Applications1707 Computer Vision and Pattern Recognition ,Industrial and Manufacturing Engineering ,Physics::Fluid Dynamics ,symbols.namesake ,020901 industrial engineering & automation ,Supersonic speed ,Jet (fluid) ,business.industry ,Mechanics ,Computer Science Applications ,Mach number ,symbols ,business - Abstract
The operating pressure of gas-assisted laser cutting and the resulting exit jet pattern is one of the most important process parameters in high-pressure laser cutting. Many studies have been done to illustrate the effect of this parameter on both laser cutting quality and laser cutting capability. However, most of these studies have been done using conical nozzles. In this paper, the exit jet from supersonic nozzle has been studied, analyzed, and simulated under three different operating conditions, namely desired design, under-expansion, and over-expansion to illustrate the effect of these operating conditions on the dynamic characteristics of the exit jet. Quasi 1-D gas dynamics theory has been used to calculate the desired design operating condition, and then an axisymmetric 2-D model has been created using the OpenFOAMⓇ Computational Fluid Dynamics (CFD) toolbox to simulate the gas-assisted laser cutting flow through the modeled supersonic nozzle. Finally, the proposed simulations have been validated by comparing the results with experimental observations reported in previous literature. The effect of the turbulent viscosity has been considered through the proposed model to better simulate real conditions. Moreover, the model has been optimized to be effectively used for engineering purposes. The simulation results are qualitatively consistent with the reported experimental measurements and they demonstrate that in the case of supersonic nozzles, the exit jet pattern is characterized by high uniformity, absence of Mach disks, and bounded shape for a long distance especially under the desired design operating conditions.
- Published
- 2019
49. Effect of X-ray and artificial aging on parchment
- Author
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Vadrucci, Monia, primary, Cicero, Cristina, additional, Mazzuca, Claudia, additional, Mercuri, Fulvio, additional, Missori, Mauro, additional, Orazi, Noemi, additional, Severini, Leonardo, additional, and Zammit, Ugo, additional
- Published
- 2021
- Full Text
- View/download PDF
50. Remote and contactless infrared imaging techniques for stratigraphical investigations in paintings on canvas
- Author
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Ceccarelli, Sofia, primary, Guarneri, Massimiliano, additional, Orazi, Noemi, additional, Francucci, Massimo, additional, Ciaffi, Massimiliano, additional, Mercuri, Fulvio, additional, Paoloni, Stefano, additional, de Collibus, Mario Ferri, additional, Zammit, Ugo, additional, and Petrucci, Francesco, additional
- Published
- 2021
- Full Text
- View/download PDF
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