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2. HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry

Author

Crocchiolo, R, primary, Ciceri, F, additional, Fleischhauer, K, additional, Oneto, R, additional, Bruno, B, additional, Pollichieni, S, additional, Sacchi, N, additional, Sormani, M P, additional, Fanin, R, additional, Bandini, G, additional, Bonifazi, F, additional, Bosi, A, additional, Rambaldi, A, additional, Alessandrino, P E, additional, Falda, M, additional, and Bacigalupo, A, additional

Published
2009
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3. A revised day +7 predictive score for transplant-related mortality: serum cholinesterase, total protein, blood urea nitrogen, γ glutamyl transferase, donor type and cell dose

Author

Sormani, M P, primary, Oneto, R, additional, Bruno, B, additional, Fiorone, M, additional, Lamparelli, T, additional, Gualandi, F, additional, Raiola, A M, additional, Dominietto, A, additional, Van Lint, M T, additional, Frassoni, F, additional, Bruzzi, P, additional, and Bacigalupo, A, additional

Published
2003
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6. Early predictors of transplant-related mortality (TRM) after allogeneic bone marrow transplants (BMT): blood urea nitrogen (BUN) and bilirubin

Author

Bacigalupo, A, primary, Oneto, R, additional, Bruno, B, additional, Soracco, M, additional, Lamparelli, T, additional, Gualandi, F, additional, Occhini, D, additional, Raiola, AM, additional, Mordini, N, additional, Berisso, G, additional, Bregante, S, additional, Dini, G, additional, Lombardi, A, additional, Van Lint, MT, additional, and Brand, R, additional

Published
1999
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7. HLA matching affects clinical outcome of adult patients undergoing haematopoietic SCT from unrelated donors: a study from the Gruppo Italiano Trapianto di Midollo Osseo and Italian Bone Marrow Donor Registry

Author

Alessandro Rambaldi, Bénédicte Bruno, Michele Falda, M P Sormani, Francesca Bonifazi, Simona Pollichieni, Almalina Bacigalupo, Alberto Bosi, P E Alessandrino, Giuseppe Bandini, Roberto Crocchiolo, Katharina Fleischhauer, R Fanin, Nicoletta Sacchi, Fabio Ciceri, Rosi Oneto, Crocchiolo, R, Ciceri, Fabio, Fleischhauer, K, Oneto, R, Bruno, B, Pollichieni, S, Sacchi, N, Sormani, Mp, Fanin, R, Bandini, G, Bonifazi, F, Bosi, A, Rambaldi, A, Alessandrino, Pe, Falda, M, and Bacigalupo, A.

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Kaplan-Meier Estimate, Hematopoietic stem cell transplantation, Young Adult, HLA Antigens, Recurrence, Transplantation Immunology, Internal medicine, Immunopathology, medicine, Humans, Young adult, Survival rate, Aged, Retrospective Studies, Transplantation, Hematology, business.industry, Histocompatibility Testing, Hematopoietic Stem Cell Transplantation, Retrospective cohort study, Middle Aged, medicine.disease, Tissue Donors, Histocompatibility, Surgery, Survival Rate, Treatment Outcome, surgical procedures, operative, Graft-versus-host disease, Italy, Hematologic Neoplasms, Multivariate Analysis, Female, business
Abstract

The importance of HLA donor-recipient matching in unrelated haematopoietic SCT (HSCT) is the subject of debate. In this retrospective study, we analyzed 805 adult patients from the Italian Registry receiving HSCT for a haematological malignancy from January 1999 to June 2006 and correlated the degree of HLA matching with transplant outcome. All patient-donor pairs had high-resolution typing at HLA-A, -B, -C, -DRB1 and -DQB1. There was a significantly higher risk of overall mortality, non-relapse mortality, graft failure and acute GVHD (aGVHD) for patients receiving HSCT from an unrelated donor with one or more low- or high-resolution mismatch/es (Mm/s). When only a single HLA Mm is present (9/10 matched pairs), mortality risk is higher than among 10/10 matched pairs in patients transplanted with acute leukaemia in the first CR ('early' patients) but not in the other patients ( advanced patients): HR 1.69, 95% CI 0.94-3.02, P = 0.08; HR = 1.03, 95% CI = 0.80-1.32, P = 0.82, for early and advanced patients, respectively. These results confirm that the advantage of a 10/10 match has a greater effect in early patients, thus suggesting that a 9/10 matched donor can be chosen in patients with advanced disease lacking a rapidly available 10/10 matched one. Bone Marrow Transplantation ( 2009) 44, 571-577; doi:10.1038/bmt.2009.67; published online 13 April 2009

Published
2009
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