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Bronchopulmonary carcinoids are low-grade tumors for which the standard treatment is surgical resection. We retrospectively evaluated the surgical outcomes. Thirteen patients underwent surgical resection for them at our institution between January 2005 and December 2016. We collected their clinicopathologic data to evaluate surgical outcomes. The 13 patients comprised seven men and six women. Complete resection was performed in all cases. All the tumors were typical carcinoids, including one oncocytic carcinoid which showed highest fluorodeoxyglucose (FDG) uptake (SUVmax 45.7). The 5-year overall survival rates were 100%. The only patient with oncocytic carcinoid developed recurrence of liver metastasis 49 months after the primary lung resection. The metastasis showed low FDG uptake (SUVmax 2.8) and its histology was typical carcinoid and not oncocytic carcinoid. Surgical outcomes in our patients were favorable. In oncocytic carcinoid, metastatic site may have a radiologic and histologic appearance different from the primary tumor.

Hintergrund. Maligne Onkozytome der grosen Speicheldrusen sind seltene epitheliale Tumoren, sie entsprechen weniger als 1% aller Speicheldrusenkarzinome. Sie sind meist in der Glandula parotis, nur zu ca. 10% in der Glandula submandibularis lokalisiert und treten etwa gleich haufig bei Frauen und Mannern auf. Der Altersgipfel liegt im 5.–6. Lebensjahrzehnt. Onkozyten sind stark vergroserte Epithelzellen mit kraftiger granularer Eosinophilie des Zytoplasmas, bedingt durch dicht gepackte und cristareiche Mitrochondrien. Die maligne Transformation aus benignen Onkozytomen ist am Nebeneinander von Onkozytenresten und atypischen onkozytaren Karzinomanteilen zu erkennen. Die Tumoren besitzen keine Kapsel und zeigen ein lokal invasives Wachstum.

An immunohistochemical study to demonstrate oncocytes in nongonadotrophic pituitary adenomas was performed. The adenomas were 10 prolactinomas, 2 ACTH-producing adenomas (ACTHomas), and 28 growth hormone-producing adenomas (GHomas); we also studied 5 pituitary oncocytomas. GHomas were divided into two groups: GHomas with (GHomas-1) and without (GHomas-2) fibrous bodies. A small number of solitary large cells showed intense cytoplasmic granular reactivity for mitochondrial protein and cytochrome oxidase, resembling oncocytes in oncocytomas. The proportions of the mitochondrial protein-positive cells ranged from zero to 2.1% (0.3±0.4%). They were more frequent in GHomas, GHomas-1 in particular, than other types of adenomas (P

Oxyphilic hepatocytes, also called hepatic oncocytes, have been found in 20 of 47 cirrhotic livers (42%) with defects of the respiratory chain. Immunohistochemical studies using antisera against cytochrome-c-oxidase (complex IV) revealed respiratory chain-deficient oxyphilic foci in 16 of the 20 cases (75%). Fourteen percent of the oxyphilic areas were deficient, whereas only 8.5% of the nonoxyphilic liver nodules showed respiratory chain defects (P < 0.004). In addition, oxyphilic foci made up about 18% of all defective areas but were present in only 11.5% of the regenerative nodules. These results illustrate that oxyphilic cell change is associated with a higher propensity for the development of respiratory chain defects, but is not obligatory for this.

Oncocytic carcinomas are uncommon; they represent 11% of all oncocytic salivary gland neoplasms, 0.5% of all epithelial salivary gland malignancies and 0.18% of all epithelial salivary gland tumors. A 65-year-old woman was admitted to our ENT clinic with a history of a painless left preauricular mass. No lymph node was palpable on either side of her neck. Computed tomography demonstrated a 3 x 3-cm solid lesion in the left parotid gland. As oncocytes and atypical cells were seen at the cytologic examination of a fine-needle aspiration biopsy, this finding suggested a malignant epithelial tumor. Total parotidectomy by preserving the facial nerve was performed. The result of the pathologic examination was oncocytic carcinoma regarding histopathologic and immunohistochemical findings and especially the invasive growth pattern. We preferred a close follow-up to an elective neck dissection, and reserved the neck dissection for a recurrence. The prognosis of oncocytic carcinomas is not well known because of their low incidence. Further investigation of the prognosis of patients with oncocytic carcinoma of the parotid gland is warranted as more cases are reported.

A rare case of ovarian adenocarcinoma with extensive oncocytic differentiation is presented. Light and electron microscopy examination and a specific stain for mitochondria (chromotrope-alcian blue) confirmed the diagnosis. The tumour cells revealed abundant granular and eosinophilic cytoplasm containing a large number of mitochondria. The tumour had a malignant infiltrative pattern and cellular atypia.

In 105 Autopsien von Neugeborenen und Kindern bis 9 Jahren und in 100 Biopsien von Knaben zwischen 9 und 17 Jahren werden die Gonaden auf das Vorkommen eosinophil granulierter onkocytenartiger Zellen im Keimepithel gepruft. Im Gesamtuntersuchungsgut kommen derartige Zellen bei 19 Knaben, d.h. bei 9,2% der Falle vor. Bei unausgewahlten Autopsiefallen sind sie nur bei annahernd 3 % der Beobachtungen zu sehen, bei Biopsien dagegen, die aus dystopen Hoden der spateren prapuberalen Altersstufe stammen, bei 16% der Falle. Morphologisch erinnern die eosinophil gekornten Zellen an Onkocyten anderer Organe. Die Granula weisen aber gewisse gestaltliche und farberische Eigenschaften auf, die mit denjenigen typischer Onkocyten nicht ubereinstimmen. Auch spricht das Auftreten dieser Zellen im Keimepithel des fruhen Kindesalters gegen die Identitat derartiger gekornter Zellen mit Onkocyten. Da die eosinophil gekornten Zellen vor allem in dystopen oder dysplastischen Hoden gefunden werden, kommt ihrem Nachweis bei Kindern moglicherweise eine gewisse Bedeutung fur die prognostische Beurteilung der spateren Hodenentwicklung zu.