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Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P less than 0.05) between 30 and 120 min and there was a significant inhibition (P less than 0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r = 0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P less than 0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.

A solitary inflammatory polyp of the stomach characterized by an eosinophilic infiltrate, fibrosis, and granuloma formation is a rare entity. The clinical and histologic findings of this lesion are distinctly different from those of diffuse eosinophilic gastroenteritis. It is not related to eosinophilic granuloma of the lung or bone. Although the polyp may cause epigastric pain or gastrointestinal hemorrhage, it is often an incidental finding. Simple excision is adequate treatment.