1. Dietary antioxidant capacity and all-cause and cause-specific mortality in the E3N/EPIC cohort study
- Author
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Valérie Dyevre, Guy Fagherazzi, Laure Dossus, Nadia Bastide, Laureen Dartois, Marie-Christine Boutron-Ruault, and Mauro Serafini
- Subjects
0301 basic medicine ,Gerontology ,Antioxidant ,Multivariate analysis ,medicine.medical_treatment ,Medicine (miscellaneous) ,Physiology ,Non-enzymatic antioxidant capacity ,E3N study ,Antioxidants ,All-cause and cause-specific mortality ,FRAP ,TRAP ,Nutrition and Dietetics ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Neoplasms ,Surveys and Questionnaires ,Humans ,Medicine ,Prospective Studies ,Risk factor ,Prospective cohort study ,Proportional Hazards Models ,030109 nutrition & dietetics ,business.industry ,Smoking ,Hazard ratio ,Reproducibility of Results ,Middle Aged ,Confidence interval ,Diet ,Quartile ,Cardiovascular Diseases ,030220 oncology & carcinogenesis ,Multivariate Analysis ,Female ,Reactive Oxygen Species ,business ,Follow-Up Studies ,Cohort study - Abstract
The cellular oxidative stress (balance between pro-oxidant and antioxidant) may be a major risk factor for chronic diseases. Antioxidant capacity of human diet can be globally assessed through the dietary non-enzymatic antioxidant capacity (NEAC). Our aim was to investigate the relationship between the NEAC and all-cause and cause-specific mortality, and to test potential interactions with smoking status, a well-known pro-oxidant factor. Among the French women of the E3N prospective cohort study initiated in 1990, including 4619 deaths among 1,199,011 persons-years of follow-up. A validated dietary history questionnaire assessed usual food intake; NEAC intake was estimated using a food composition table from two different methods: ferric ion reducing antioxidant power (FRAP) and total radical-trapping antioxidant parameter (TRAP). Hazard ratio (HR) estimates and 95 % confidence intervals (CI) were derived from Cox proportional hazards regression models. In multivariate analyses, FRAP dietary equivalent intake was inversely associated with mortality from all-causes (HR for the fourth vs. the first quartile: HR4 = 0.75, 95 % CI 0.67, 0.83, p trend
- Published
- 2016
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