1. Complete heart block in association with graft-versus-host disease
- Author
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N Lee, Zuhair K. Ballas, Myrl Holida, A. L. Gilman, S Rumelhart, Frederick D. Goldman, Neil W. Kooy, and D. L. Atkins
- Subjects
Male ,medicine.medical_specialty ,Heart disease ,Exacerbation ,Heart block ,medicine.medical_treatment ,Graft vs Host Disease ,chemical and pharmacologic phenomena ,immune system diseases ,Internal medicine ,medicine ,Humans ,Bone Marrow Transplantation ,Transplantation ,Severe combined immunodeficiency ,Respiratory distress ,Bundle branch block ,business.industry ,Infant ,Immunosuppression ,Hematology ,medicine.disease ,Surgery ,Heart Block ,surgical procedures, operative ,Graft-versus-host disease ,Cardiology ,business ,Immunosuppressive Agents - Abstract
An infant who received haploidentical BM for severe combined immunodeficiency (SCID) developed acute, reversible complete heart block in association with an exacerbation of GVHD. Respiratory distress and myocardial dysfunction were also seen with this and previous GVHD exacerbations. The patient had not received chemotherapy or radiation prior to BMT. The complete heart block resolved after 1 week of intensive immunosuppression. The association of complete heart block with GVHD is important because the heart block is potentially reversible with prompt, aggressive control of the GVHD.
- Published
- 1998
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