89 results on '"Murphy, James M."'
Search Results
2. An immunohistochemical atlas of necroptotic pathway expression
3. Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion
4. A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation
5. SMCHD1 has separable roles in chromatin architecture and gene silencing that could be targeted in disease
6. CaMKK2 as an emerging treatment target for bipolar disorder
7. Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL
8. MLKL deficiency protects against low-grade, sterile inflammation in aged mice
9. Role of necroptosis in kidney health and disease
10. Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria
11. Human RIPK3 C-lobe phosphorylation is essential for necroptotic signaling
12. Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms
13. The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL
14. Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL
15. Ferroptosis mediates selective motor neuron death in amyotrophic lateral sclerosis
16. Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis
17. Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK
18. Correction to: Evaluation of a new 12 km regional perturbed parameter ensemble over Europe
19. SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity
20. Evaluation of a new 12 km regional perturbed parameter ensemble over Europe
21. Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance
22. The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation
23. A perturbed parameter ensemble of HadGEM3-GC3.05 coupled model projections: part 1: selecting the parameter combinations
24. A perturbed parameter ensemble of HadGEM3-GC3.05 coupled model projections: part 2: global performance and future changes
25. Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
26. A family harboring an MLKL loss of function variant implicates impaired necroptosis in diabetes
27. Mechanism of NanR gene repression and allosteric induction of bacterial sialic acid metabolism
28. A toolbox for imaging RIPK1, RIPK3, and MLKL in mouse and human cells
29. Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix
30. Focal Adhesion Kinase Activity and Localization is Critical for TNF-α-Induced Nuclear Factor-κB Activation
31. The necroptotic cell death pathway operates in megakaryocytes, but not in platelet synthesis
32. The regulation of necroptosis by post-translational modifications
33. Necroptosis is dispensable for the development of inflammation-associated or sporadic colon cancer in mice
34. BAK core dimers bind lipids and can be bridged by them
35. Phosphorylation by Aurora B kinase regulates caspase-2 activity and function
36. MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
37. A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
38. Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues
39. Targeting focal adhesion kinase in cancer cells and the tumor microenvironment
40. Necroptosis is dispensable for motor neuron degeneration in a mouse model of ALS
41. FAK and Pyk2 activity promote TNF-α and IL-1β-mediated pro-inflammatory gene expression and vascular inflammation
42. Finding plausible and diverse variants of a climate model. Part II: development and validation of methodology
43. The anticonvulsive Phenhydan® suppresses extrinsic cell death
44. A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
45. Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters
46. Cryo-EM structure of an essential Plasmodium vivax invasion complex
47. Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
48. The molecular basis of JAK/STAT inhibition by SOCS1
49. The brace helices of MLKL mediate interdomain communication and oligomerisation to regulate cell death by necroptosis
50. Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association
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