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Your search keyword '"Moreno-Küstner, Berta"' showing total 13 results
Start Over Author "Moreno-Küstner, Berta" Publisher springer science and business media llc
13 results on '"Moreno-Küstner, Berta"'

4. Effectiveness and implementation of an online intervention (MINDxYOU) for reducing stress and promote mental health among healthcare workers in Spain: a study protocol for a stepped-wedge cluster randomized trial

Author

López-del-Hoyo, Yolanda, primary, Fernández-Martínez, Selene, additional, Pérez-Aranda, Adrián, additional, Barceló-Soler, Alberto, additional, Guzman-Parra, Jose, additional, Varela-Moreno, Esperanza, additional, Campos, Daniel, additional, Monreal-Bartolomé, Alicia, additional, Beltrán-Ruiz, María, additional, Moreno-Küstner, Berta, additional, Mayoral-Cleries, Fermín, additional, and García-Campayo, Javier, additional

Published
2022
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10. Suicidality in primary care patients who present with sadness and anhedonia: a prospective European study

Author

Moreno-Küstner, Berta, primary, Jones, Rebeca, additional, Švab, Igor, additional, Maaroos, Heidi, additional, Xavier, Miguel, additional, Geerlings, Mirjam, additional, Torres-González, Francisco, additional, Nazareth, Irwin, additional, Motrico-Martínez, Emma, additional, Montón-Franco, Carmen, additional, Gil-de-Gómez, María José, additional, Sánchez-Celaya, Marta, additional, Díaz-Barreiros, Miguel Ángel, additional, Vicens-Caldentey, Catalina, additional, and King, Michael, additional

Published
2016
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12. Prediction of depression in European general practice attendees: the PREDICT study

Author

King, Michael, primary, Weich, Scott, additional, Torres-González, Francisco, additional, Švab, Igor, additional, Maaroos, Heidi-Ingrid, additional, Neeleman, Jan, additional, Xavier, Miguel, additional, Morris, Richard, additional, Walker, Carl, additional, Bellón-Saameño, Juan A, additional, Moreno-Küstner, Berta, additional, Rotar, Danica, additional, Rifel, Janez, additional, Aluoja, Anu, additional, Kalda, Ruth, additional, Geerlings, Mirjam I, additional, Carraça, Idalmiro, additional, de Almeida, Manuel Caldas, additional, Vicente, Benjamin, additional, Saldivia, Sandra, additional, Rioseco, Pedro, additional, and Nazareth, Irwin, additional

Published
2006
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13. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Author

Andlauer, Till FM, Guzman-Parra, Jose, Streit, Fabian, Strohmaier, Jana, González, Maria José, Gil Flores, Susana, Cabaleiro Fabeiro, Francisco J, Del Río Noriega, Francisco, Perez, Fermin Perez, Haro González, Jesus, Orozco Diaz, Guillermo, De Diego-Otero, Yolanda, Moreno-Küstner, Berta, Auburger, Georg, Degenhardt, Franziska, Heilmann-Heimbach, Stefanie, Herms, Stefan, Hoffmann, Per, Frank, Josef, Foo, Jerome C, Treutlein, Jens, Witt, Stephanie H, Cichon, Sven, Kogevinas, Manolis, Bipolar Disorder Working Group Of The Psychiatric Genomics Consortium, Consortium, Major Depressive Disorder Working Group Of The Psychiatric Genomics, Rivas, Fabio, Mayoral, Fermín, Müller-Myhsok, Bertram, Forstner, Andreas J, Nöthen, Markus M, and Rietschel, Marcella

Subjects
Depressive Disorder, Major, Bipolar Disorder, Case-Control Studies, Schizophrenia, Humans, Genetic Predisposition to Disease, 3. Good health
Abstract

Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development.

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