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Start Over Author "Montesano M" Publisher springer science and business media llc
8 results on '"Montesano M"'

2. High-Throughput Sample Preparation for the Quantitation of Acephate, Methamidophos, Omethoate, Dimethoate, Ethylenethiourea, and Propylenethiourea in Human Urine Using 96-Well–Plate Automated Extraction and High-Performance Liquid Chromatography–Tandem Mass Spectrometry

Author

Jayatilaka, Nayana K., primary, Angela Montesano, M., additional, Whitehead, Ralph D., additional, Schloth, Sara J., additional, Needham, Larry L., additional, and Barr, Dana Boyd, additional

Published
2010
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8. miR-22 suppresses DNA ligase III addiction in multiple myeloma

Author

Pierfrancesco Tassone, Emanuela Altomare, Nicola Amodio, Lorenza Maltese, Francesca Scionti, Valeria Zuccalà, Mariamena Arbitrio, Eugenio Morelli, Marco Rossi, Martina Montesano, Daniele Caracciolo, Maria Eugenia Gallo Cantafio, Cirino Botta, Antonino Neri, Pierosandro Tagliaferri, Daniela Talarico, Maria Teresa Di Martino, Katia Todoerti, Caracciolo D., Di Martino M.T., Amodio N., Morelli E., Montesano M., Botta C., Scionti F., Talarico D., Altomare E., Gallo Cantafio M.E., Zuccala V., Maltese L., Todoerti K., Rossi M., Arbitrio M., Neri A., Tagliaferri P., and Tassone P.

Subjects
0301 basic medicine, Genome instability, Cancer Research, miR-22, LIG3, DNA repair, DNA damage, Apoptosis, LIG3, Article, DNA Ligase ATP, 03 medical and health sciences, 0302 clinical medicine, microRNA, Biomarkers, Tumor, Tumor Cells, Cultured, Humans, Poly-ADP-Ribose Binding Proteins, Cell Proliferation, miRNA, chemistry.chemical_classification, Regulation of gene expression, Gene knockdown, DNA ligase, Leukemia, Chemistry, Hematology, Prognosis, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, multiple myeloma, MicroRNAs, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer research, pharmacology, DNA Damage
Abstract

Multiple myeloma (MM) is a hematologic malignancy characterized by high genomic instability. Here we provide evidence that hyper-activation of DNA ligase III (LIG3) is crucial for genomic instability and survival of MM cells. LIG3 mRNA expression in MM patients correlates with shorter survival and even increases with more advanced stage of disease. Knockdown of LIG3 impairs MM cells viability in vitro and in vivo, suggesting that neoplastic plasmacells are dependent on LIG3-driven repair. To investigate the mechanisms involved in LIG3 expression, we investigated the post-transcriptional regulation. We identified miR-22-3p as effective negative regulator of LIG3 in MM. Enforced expression of miR-22 in MM cells downregulated LIG3 protein, which in turn increased DNA damage inhibiting in vitro and in vivo cell growth. Taken together, our findings demonstrate that myeloma cells are addicted to LIG3, which can be effectively inhibited by miR-22, promoting a novel axis of genome stability regulation.

Published
2018

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