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Your search keyword '"Moniotte, Stéphane"' showing total 13 results
Start Over Author "Moniotte, Stéphane" Publisher springer science and business media llc
13 results on '"Moniotte, Stéphane"'

1. Usefulness of serum neurofilament light in the assessment of neurologic outcome in the pediatric population: a systematic literature review

Author

Jacobs Sariyar, Aurélie, Van Pesch, Vincent, Nassogne, Marie-Cécile, Moniotte, Stéphane, Momeni, Mona, and UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire

Subjects
Pediatric, Brain Diseases, Neurofilament light, Adolescent, Neurodevelopment, Infant, Newborn, Intermediate Filaments, Child, Preschool, Pediatrics, Perinatology and Child Health, Neurotoxicity, Animals, Humans, Anesthesia, Prospective Studies, Perioperative, Child, Biomarkers, Retrospective Studies
Abstract

Children undergoing general anesthesia and surgery in the early years of life are exposed to the possible neurotoxicity of anesthetic agents. Prospective studies have shown deficits in behavior, executive function, social communication, and motor function in children undergoing anesthesia and surgery. Different biomarkers of neuronal injury have been evaluated neuronal injury in the pediatric population, among which neurofilaments represent a significant advantage as they are proteins exclusively expressed in neuronal tissue. Our aim was to evaluate the utility of serum neurofilament light (NfL) as a prognostic biomarker of neuronal injury in the pediatric population. A literature search was performed on PubMed, Embase, and Cochrane Databases in November 2022 for studies concerning serum NfL in the pediatric population in addition to a neurological assessment. Inclusion criteria were as follows: (1) prospective or retrospective studies, (2) studies including pediatric population until the age of 18 years, (3) serum NfL sampling, and (4) evaluation of neurological outcome. Data collection regarding study design, pediatric age, serum NfL levels, and results for neurological assessment were extracted from each study. Four manuscripts met the inclusion criteria and evaluated the prognostic utility of serum NfL in neonatal encephalopathy in correlation with the neurodevelopmental outcome that was assessed by the Bayley Scales of Infant Development until the age of 2 years. Children with neonatal encephalopathy showed significantly higher serum NfL vs. healthy controls and high serum NfL levels predicted an adverse neurological outcome. The decrease of serum NfL to a nadir point between 10 and 15 years old reflects the brain growth in healthy controls. No studies were available in the perioperative period. Conclusions: Serum NfL is a valuable biomarker in evaluating neuronal injury in the pediatric population. Further studies with perioperative serial sampling of serum NfL combined with standardized neurodevelopmental tests should be conducted to evaluate the neurotoxicity of anesthetic agents and monitor the effectiveness of specific neuroprotective strategies in pediatric patients undergoing anesthesia and surgery. What is Known: • Preclinical animal data have shown neurotoxicity of the anesthetic agents in the developing brain. • Data regarding anesthetic neurotoxicity in humans show limitations and no objective tools are available. What is New: • This systematic review showed that serum NfL is a valuable biomarker of neuronal injury in the pediatric population. • Perioperative use of serum NfL may be considered in future trials evaluating anesthetic neurotoxicity in the pediatric population and in monitoring neuroprotective strategies.

Published
2023

4. Recent Experience and Follow-Up After Surgical Closure of Secundum Atrial Septal Defect in 120 Children

Author

UCL - (SLuc) Service de chirurgie cardiovasculaire et thoracique, UCL - (SLuc) Service de cardiologie pédiatrique, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, De Beco, Geoffroy, Mambour, Natasha, Vô, Christophe, Van Houtte, Laetitia, Moniotte, Stéphane, Poncelet, Alain, Sluysmans, Thierry, UCL - (SLuc) Service de chirurgie cardiovasculaire et thoracique, UCL - (SLuc) Service de cardiologie pédiatrique, UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, De Beco, Geoffroy, Mambour, Natasha, Vô, Christophe, Van Houtte, Laetitia, Moniotte, Stéphane, Poncelet, Alain, and Sluysmans, Thierry

Abstract

While percutaneous catheter closure proves an effective treatment for secundum atrial septal defect (ASD2), some child patients require surgical closure. We assessed the risks associated with isolated surgical ASD2 closure by reviewing the outcomes of 120 children operated on between 1999 and 2011 (mean age 4.6 ± 3.9 years, mean weight 17 ± 12 kg). Direct sutures were performed in 4% and patch closures in 96%. The mean cardiopulmonary bypass duration was 38 ± 14 min, aortic cross-clamp time 19 ± 9 min, intensive care unit length of stay 1.6 ± 1.1 days, hospital stay 11.2 ± 5.1 days. There were no complications in 60 patients (50%) and major complications in 8 (6.7%), with 1 patient (0.8%) dying of pneumonia-induced sepsis, 2 (1.7%) requiring revision surgery, 3 (2.5%) requiring invasive treatment (2 pericardial drainage, 1 successful resuscitation), and 2 (1.7%) presenting thromboembolisms (1 cerebral stroke, 1 cardiac thrombus). In hospital minor complications occurred in 22 patients: 17 pericardial effusions (15%), 15 infections requiring treatment (12.5%), 1 sternal instability (0.8%), 4 anemias requiring transfusion (3.3%), 7 pulmonary atelectasis (6%), and 2 post-extubation glottis edema (1.7%). At early outpatient follow-up, complications occurred in 21 patients: 16 (13.3%) pericardial effusions, 4 (3.3%) infections requiring treatment, and 3 (2.5%) keloid scarring. No complications occurred during long-term follow-up. In line with published data, mortality was low (0.8%), yet major complications (6.7%) were more common in these cases than those following percutaneous ASD2 closure. Minor complications were frequent (43%) with no long-term sequelae.

Published
2018

12. Iron overload in polytransfused patients without heart failure is associated with subclinical alterations of systolic left ventricular function using cardiovascular magnetic resonance tagging

Author

Seldrum, Stéphanie, primary, Pierard, Sophie, additional, Moniotte, Stéphane, additional, Vermeylen, Christiane, additional, Vancraeynest, David, additional, Pasquet, Agnès, additional, Vanoverschelde, Jean-Louis, additional, and Gerber, Bernhard L, additional

Published
2011
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