1. Concordant bone marrow involvement of diffuse large B-cell lymphoma represents a distinct clinical and biological entity in the era of immunotherapy
- Author
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M. Ponzoni, Wayne Tam, J.H.J.M. van Krieken, Lijuan Deng, Praveen Jain, Luis Fayad, Jianxiang Wang, Govind Bhagat, Ganiraju C. Manyam, Hagop M. Kantarjian, L. J. Medeiros, Y Liu, Ken H. Young, Karen Dybkær, Jorge E. Cortes, C. Visco, Yong Li, Jane N. Winter, Zhilei Yao, Robert Z. Orlowski, Anna Ferreri, Alexandar Tzankov, Zijun Y. Xu-Monette, M A Piris, Eric D. Hsi, Yongping Song, Michael Boe Møller, Yao, Z., Deng, L., Xu-Monette, Z. Y., Manyam, G. C., Jain, P., Tzankov, A., Visco, C., Bhagat, G., Wang, J., Dybkaer, K., Tam, W., Hsi, E. D., Van Krieken, J. H., Ponzoni, M., Ferreri, A. J. M., Moller, M. B., Winter, J. N., Piris, M. A., Fayad, L., Liu, Y., Song, Y., Orlowski, R. Z., Kantarjian, H., Medeiros, L. J., Li, Y., Cortes, J., and Young, K. H.
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Male ,Oncology ,Cancer Research ,Pathology ,Lymphoma ,Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] ,medicine.medical_treatment ,0302 clinical medicine ,International Prognostic Index ,Bone Marrow ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,80 and over ,Stage (cooking) ,Aged, 80 and over ,Bone Marrow/drug effects ,Hematology ,Middle Aged ,Prognosis ,Diffuse ,Lymphoma, Large B-Cell, Diffuse/drug therapy ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Immunotherapy/methods ,Female ,Rituximab ,Immunotherapy ,Lymphoma, Large B-Cell, Diffuse ,Adolescent ,Adult ,Aged ,Disease-Free Survival ,Humans ,Immunologic Factors ,Young Adult ,medicine.drug ,medicine.medical_specialty ,Article ,03 medical and health sciences ,All institutes and research themes of the Radboud University Medical Center ,Internal medicine ,Large B-Cell ,medicine ,Performance status ,business.industry ,medicine.disease ,Antineoplastic Combined Chemotherapy Protocols/therapeutic use ,Bone marrow ,business ,Immunologic Factors/metabolism ,Diffuse large B-cell lymphoma ,030215 immunology - Abstract
In diffuse large B-cell lymphoma (DLBCL), the clinical and biological significance of concordant and discordant bone marrow (BM) involvement have not been well investigated. We evaluated 712 de novo DLBCL patients with front-line rituximab-containing treatment, including 263 patients with positive and 449 with negative BM status. Compared with negative BM disease, concordant BM adversely impacted overall and progression-free survival, independent of the International Prognostic Index (IPI) and cell-of-origin classification. Once BM is concordantly involved, poor prognosis was not associated with the extent of BM involvement. Conversely, patients with discordant BM showed favorable overall survival similar to stage I-II DLBCL. A BM-adjusted IPI, using three parameters: concordant BM involvement, age >60 years, and performance status >1, improves the risk stratification for DLBCL with positive BM. Intensive immunochemotherapy seemingly rendered survival benefit for patients with concordant BM, as did rituximab maintenance for the discordant BM group. Frequently revealing adverse clinical and molecular characteristics, patients with concordant BM demonstrated gene expression signatures relevant to tumor cell proliferation, migration and immune escape. In conclusion, clinical and biological heterogeneity is seen in DLBCL with positive BM but concordant BM involvement represents a distinct subset with unfavorable gene signatures, high-risk clinicopathologic features and poor prognosis.
- Published
- 2017
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