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Start Over Author "Merker, M." Publisher springer science and business media llc
10 results on '"Merker, M."'

1. Correction to: No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease

Author

Thiel, U., primary, Schober, S. J., additional, Ranft, A., additional, Gassmann, H., additional, Jabar, S., additional, Gall, K., additional, von Lüttichau, I., additional, Wawer, A., additional, Koscielniak, E., additional, Diaz, M. A., additional, Ussowicz, M., additional, Kazantsev, I., additional, Afanasyev, B., additional, Merker, M., additional, Klingebiel, T., additional, Prete, A., additional, Gruhn, B., additional, Bader, P., additional, Jürgens, H., additional, Dirksen, U., additional, Handgretinger, R., additional, Burdach, S., additional, and Lang, P., additional

Published
2021
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2. No difference in survival after HLA mismatched versus HLA matched allogeneic stem cell transplantation in Ewing sarcoma patients with advanced disease

Author

Thiel, U., primary, Schober, S. J., additional, Ranft, A., additional, Gassmann, H., additional, Jabar, S., additional, Gall, K., additional, von Lüttichau, I., additional, Wawer, A., additional, Koscielniak, E., additional, Diaz, M. A., additional, Ussowicz, M., additional, Kazantsev, I., additional, Afanasyev, B., additional, Merker, M., additional, Klingebiel, T., additional, Prete, A., additional, Gruhn, B., additional, Bader, P., additional, Jürgens, H., additional, Dirksen, U., additional, Handgretinger, R., additional, Burdach, S., additional, and Lang, P., additional

Published
2021
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4. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.

Author

Göbel, K, Pankratz, S, Asaridou, C-M, Herrmann, AM, Bittner, S, Merker, M, Ruck, T, Glumm, S, Langhauser, F, Kraft, P, Krug, TF, Breuer, J, Herold, M, Gross, CC, Beckmann, D, Korb-Pap, A, Schuhmann, MK, Kuerten, S, Mitroulis, I, Ruppert, C, Nolte, MW, Panousis, C, Klotz, L, Kehrel, B, Korn, T, Langer, HF, Pap, T, Nieswandt, B, Wiendl, H, Chavakis, T, Kleinschnitz, C, Meuth, SG, Göbel, K, Pankratz, S, Asaridou, C-M, Herrmann, AM, Bittner, S, Merker, M, Ruck, T, Glumm, S, Langhauser, F, Kraft, P, Krug, TF, Breuer, J, Herold, M, Gross, CC, Beckmann, D, Korb-Pap, A, Schuhmann, MK, Kuerten, S, Mitroulis, I, Ruppert, C, Nolte, MW, Panousis, C, Klotz, L, Kehrel, B, Korn, T, Langer, HF, Pap, T, Nieswandt, B, Wiendl, H, Chavakis, T, Kleinschnitz, C, and Meuth, SG

Abstract

Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify coagulation factor XII (FXII), the initiator of the intrinsic coagulation cascade and the kallikrein-kinin system, as a specific immune cell modulator. High levels of FXII activity are present in the plasma of MS patients during relapse. Deficiency or pharmacologic blockade of FXII renders mice less susceptible to experimental autoimmune encephalomyelitis (a model of MS) and is accompanied by reduced numbers of interleukin-17A-producing T cells. Immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner and involves alterations in intracellular cyclic AMP formation. Our study demonstrates that a member of the plasmatic coagulation cascade is a key mediator of autoimmunity. FXII inhibition may provide a strategy to combat MS and other immune-related disorders.

Published
2016

5. Treatment of relapse after allogeneic stem cell transplantation in children and adolescents with ALL: the Frankfurt experience

Author

Willasch, A M, primary, Salzmann-Manrique, E, additional, Krenn, T, additional, Duerken, M, additional, Faber, J, additional, Opper, J, additional, Kreyenberg, H, additional, Bager, R, additional, Huenecke, S, additional, Cappel, C, additional, Bremm, M, additional, Pfirrmann, V, additional, Merker, M, additional, Ullrich, E, additional, Bakhtiar, S, additional, Rettinger, E, additional, Jarisch, A, additional, Soerensen, J, additional, Klingebiel, T E, additional, and Bader, P, additional

Published
2016
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