1. Prevalence of the Japanese high bleeding risk criteria and its prognostic significance for fatal bleeding in patients with acute myocardial infarction
- Author
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Yasuhiko Sakata, Katsuki Okada, Tetsuhisa Kitamura, Hiroshi Sato, Yasushi Sakata, Tomoharu Dohi, Shungo Hikoso, Taiki Sato, Shinichiro Suna, Akihiro Sunaga, Hirota Kida, Daisaku Nakatani, Issei Komuro, Bolrathanak Oeun, Hiroya Mizuno, Masatsugu Hori, and Yohei Sotomi
- Subjects
medicine.medical_specialty ,business.industry ,030204 cardiovascular system & hematology ,Vascular surgery ,medicine.disease ,Cardiac surgery ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Cohort ,medicine ,Clinical endpoint ,Cumulative incidence ,In patient ,030212 general & internal medicine ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Risk criteria - Abstract
The Japanese high-bleeding-risk criteria (Japanese-HBR), modified criteria of the Academic Research Consortium (ARC) HBR, has been recently proposed. We aimed to investigate the prevalence of the ARC-HBR and the Japanese-HBR, and to assess their prognostic significance in patients with acute myocardial infarction (AMI). We applied the ARC-HBR and the Japanese-HBR criteria to the OACIS prospective multicenter acute myocardial infarction registry (12,093 patients, 66 ± 12 years, 9,096 males). The primary endpoint was fatal bleeding (BARC-5). Median follow-up duration was 4.84 [inter-quartile range 1.35, 5.01] years. Prevalence of the ARC-HBR was 43.8%, while that of the Japanese-HBR was 61.8%. Cumulative incidence of fatal bleeding was higher in the ARC-HBR group than in the no ARC-HBR group at 1 year (1.3 vs. 0.6%) and at 5 years (2.0 vs. 0.7%). The Kaplan–Meier curves stratified by the Japanese-HBR criteria more prominently diverged (1.3 vs. 0.2% at 1 year; and 1.9 vs. 0.3% at 5 years). The Japanese-HBR criteria showed superior discriminative performance over the ARC-HBR criteria (C-statistics: 0.677 vs. 0.598, P
- Published
- 2021