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11 results on '"Martins, Patricia"'

2. Assessment of calcinosis in Portuguese patients with systemic sclerosis — a multicenter study

Author

Samões, Beatriz, primary, Guimarães da Fonseca, Diogo, additional, Beirão, Tiago, additional, Costa, Flávio, additional, Vieira, Romana, additional, Terroso, Georgina, additional, Ferreira, Raquel Miriam, additional, Nicolau, Rafaela, additional, Saraiva, André, additional, Salvador, Maria João, additional, Duarte, Ana Catarina, additional, Cordeiro, Ana, additional, Vilas-Boas, João Paulo, additional, Genrinho, Inês, additional, Bento da Silva, Ana, additional, Gago, Laura, additional, Resende, Catarina, additional, Martins, Patricia, additional, Madeira, Nathalie, additional, Dinis, Sara, additional, Couto, Maura, additional, Santos, Inês, additional, Araújo, Filipe, additional, Mourão, Ana Filipa, additional, Gomes Guerra, Miguel, additional, Oliveira, Margarida, additional, Daniel, Alexandra, additional, Rodrigues, Marília, additional, Dantas Soares, Catarina, additional, Parente, Hugo, additional, Furtado, Carolina, additional, Fontes, Tomás, additional, and Abelha-Aleixo, Joana, additional

Published
2023
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3. Imaging of photoacoustic-mediated permeabilization of giant unilamellar vesicles (GUVs)

Author

Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies, Pereira, Diogo A, Silva, Alexandre D, Martins, Patricia AT, Piedade, Ana P, Martynowych, Dmitro, Veysset, David, Moreno, Maria João, Serpa, Carlos, Nelson, Keith A, Arnaut, Luis G, Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies, Pereira, Diogo A, Silva, Alexandre D, Martins, Patricia AT, Piedade, Ana P, Martynowych, Dmitro, Veysset, David, Moreno, Maria João, Serpa, Carlos, Nelson, Keith A, and Arnaut, Luis G

Abstract

© 2021, The Author(s). Target delivery of large foreign materials to cells requires transient permeabilization of the cell membrane without toxicity. Giant unilamellar vesicles (GUVs) mimic the phospholipid bilayer of the cell membrane and are also useful drug delivery vehicles. Controlled increase of the permeability of GUVs is a delicate balance between sufficient perturbation for the delivery of the GUV contents and damage to the vesicles. Here we show that photoacoustic waves can promote the release of FITC-dextran or GFP from GUVs without damage. Real-time interferometric imaging offers the first movies of photoacoustic wave propagation and interaction with GUVs. The photoacoustic waves are seen as mostly compressive half-cycle pulses with peak pressures of ~ 1 MPa and spatial extent FWHM ~ 36 µm. At a repetition rate of 10 Hz, they enable the release of 25% of the FITC-dextran content of GUVs in 15 min. Such photoacoustic waves may enable non-invasive targeted release of GUVs and cell transfection over large volumes of tissues in just a few minutes.

Published
2022

8. Analysis of enteroendocrine cell populations in the human colon

Author

Martins, Patricia, primary, Fakhry, Josiane, additional, de Oliveira, Enio Chaves, additional, Hunne, Billie, additional, Fothergill, Linda J., additional, Ringuet, Mitchell, additional, Reis, Débora d’Ávila, additional, Rehfeld, Jens F., additional, Callaghan, Brid, additional, and Furness, John B., additional

Published
2016
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10. Molecular Distillation

Author

Moraes, Elenise Bannwart De, primary, Martins, Patricia Fazzio, additional, Batistella, César Benedito, additional, Alvarez, Mario Eusebio Torres, additional, Filho, Rubens Maciel, additional, and Maciel, Maria Regina Wolf, additional

Published
2006
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