1. [Untitled]
- Author
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Kevin P. White, Joëlle R. Pérusse, Sujun Hua, Xiang-Jun Lu, Gabor Halasz, Marinus F. van Batenburg, and Harmen J. Bussemaker
- Subjects
Genetics ,0303 health sciences ,Tiling array ,genetic structures ,biology ,Anopheles gambiae ,Genomics ,Computational biology ,biology.organism_classification ,3. Good health ,03 medical and health sciences ,Nucleic acid thermodynamics ,0302 clinical medicine ,DNA microarray ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
We have developed a method for interpreting genomic tiling array data, implemented as the program TranscriptionDetector. Probed loci expressed above background are identified by combining replicates in a way that makes minimal assumptions about the data. We performed medium-resolution Anopheles gambiae tiling array experiments and found extensive transcription of both coding and non-coding regions. Our method also showed improved detection of transcriptional units when applied to high-density tiling array data for ten human chromosomes.
- Published
- 2006
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