424 results on '"Marchini, A."'
Search Results
2. Cropping system support in downy mildew control in basil in organic farming: a two-year open field experiment
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La Placa, L, primary, Cornali, S, additional, Bertinaria, F, additional, Rossetti, A, additional, Marchini, M, additional, Reggiani, R, additional, and Battilani, P, additional
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- 2024
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3. Second-order sufficient conditions in optimal control of evolution systems
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Frankowska, H., primary, Marchini, E. M., additional, and Mazzola, M., additional
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- 2024
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4. Play it safe: renal function after bilateral flexible ureteroscopy for kidney stones
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Danilovic, Alexandre, primary, Suartz, Caio Vinicius, additional, Torricelli, Fabio Cesar Miranda, additional, Marchini, Giovanni Scala, additional, Batagello, Carlos, additional, Vicentini, Fabio Carvalho, additional, Nahas, William C., additional, and Mazzucchi, Eduardo, additional
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- 2024
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5. Associations between continuous glucose monitoring (CGM) metrics and psycholinguistic measures: a correlational study
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Marchini, Francesco, primary, Caputo, Andrea, additional, Convertino, Alessio, additional, Giuliani, Chiara, additional, Bitterman, Olimpia, additional, Pitocco, Dario, additional, Fornengo, Riccardo, additional, Lovati, Elisabetta, additional, Forte, Elisa, additional, Sciacca, Laura, additional, and Napoli, Angela, additional
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- 2024
- Full Text
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6. Loss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice
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Favero, Andrea, primary, Segatto, Ilenia, additional, Capuano, Alessandra, additional, Mattevi, Maria Chiara, additional, Rampioni Vinciguerra, Gian Luca, additional, Musco, Lorena, additional, D’Andrea, Sara, additional, Dall’Acqua, Alessandra, additional, Gava, Chiara, additional, Perin, Tiziana, additional, Massarut, Samuele, additional, Marchini, Cristina, additional, Baldassarre, Gustavo, additional, Spessotto, Paola, additional, and Belletti, Barbara, additional
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- 2024
- Full Text
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7. GPR15-mediated T cell recruitment during acute viral myocarditis facilitated virus elimination and improved outcome
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Stoffers, Bastian, primary, Wolf, Hanna, additional, Bacmeister, Lucas, additional, Kupsch, Svenja, additional, Vico, Tamara, additional, Marchini, Timoteo, additional, Brehm, Maria A., additional, Yan, Isabell, additional, Becher, P. Moritz, additional, Ardeshirdavani, Armin, additional, Escher, Felicitas, additional, Kim, Sangwon V., additional, Klingel, Karin, additional, Kirchhof, Paulus, additional, Blankenberg, Stefan, additional, Zeller, Tanja, additional, Wolf, Dennis, additional, Hilgendorf, Ingo, additional, Westermann, Dirk, additional, and Lindner, Diana, additional
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- 2023
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8. SIRT6 promotes metastasis and relapse in HER2-positive breast cancer
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Andreani, Cristina, primary, Bartolacci, Caterina, additional, Persico, Giuseppe, additional, Casciaro, Francesca, additional, Amatori, Stefano, additional, Fanelli, Mirco, additional, Giorgio, Marco, additional, Galié, Mirco, additional, Tomassoni, Daniele, additional, Wang, Junbiao, additional, Zhang, Xiaoting, additional, Bick, Gregory, additional, Coppari, Roberto, additional, Marchini, Cristina, additional, and Amici, Augusto, additional
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- 2023
- Full Text
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9. Erythropoietic protoporphyria: case reports for clinical and therapeutic hints
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Tumminelli, Cristina, primary, Burlo, Francesca, additional, Pastore, Serena, additional, Severini, Giovanni Maria, additional, Berti, Irene, additional, Marchini, Stefano, additional, Zanon, Davide, additional, De Martino, Eleonora, additional, and Tommasini, Alberto, additional
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- 2023
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10. Ephemeris Updates for Seven Selected Hatnet Survey Transiting Exoplanets
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Poro, A., primary, Farahani, F. A., additional, Jahangiri, E., additional, Sarostad, A., additional, Gozarandi, M., additional, Haghgou, M., additional, Abolhassani, F., additional, Fakhrabadi, A., additional, Jongen, Y., additional, Wünsche, A., additional, Naves, R, additional, Guerra, P., additional, Marchini, A., additional, Salisbury, M., additional, Ehrenberger, R., additional, and Hentunen, V-P., additional
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- 2023
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11. Remote ischemic preconditioning prevents sarcolemmal-associated proteolysis by MMP-2 inhibition
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Bin, Eliana P., primary, Zaobornyj, Tamara, additional, Garces, Mariana, additional, D’Annunzio, Verónica, additional, Buchholz, Bruno, additional, Marchini, Timoteo, additional, Evelson, Pablo, additional, Gelpi, Ricardo J., additional, and Donato, Martín, additional
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- 2023
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12. The chronicles of a small invader: the canal, the core and the tsunami
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N. Mancin, R. Guastella, J. T. Carlton, A. Caruso, M. Cobianchi, J. Evans, L. Capotondi, L. Langone, and A. Marchini
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Ecology ,Ecology, Evolution, Behavior and Systematics - Published
- 2022
13. Common and rare variant associations with clonal haematopoiesis phenotypes
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Kessler, M.D., Damask, A., O'Keeffe, S., Banerjee, N., Li, D., Watanabe, K., Marketta, A., VanMeter, M., Horowitz, J., Tang, J., Kosmicki, J.A., Rajagopal, V.M., Zou, Y., Houvras, Y., Ghosh, A., Gilles, C., Mbatchou, J., White, R.R., Verweij, N., Bovijn, J., Parikshak, N.N., LeBlanc, M.G., Jones, M., Glass, D.J., Lotta, L.A., Cantor, M.N., Atwal, G.S., Locke, A.E., Ferreira, M.A.R., Deering, R., Paulding, C., Schuldiner, A.R., Thurston, G., Ferrando, A.A., Salerno, W., Reid, J.G., Overton, J.D., Marchini, J., Kang, H.M., Baras, A., Abecasis, G.R., Jorgenson, E., and Semrau, S.
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Multidisciplinary ,Cardiovascular Diseases ,Humans ,COVID-19 ,Clonal Hematopoiesis - Abstract
Clonal haematopoiesis involves the expansion of certain blood cell lineages and has been associated with ageing and adverse health outcomes
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- 2022
14. Author Correction: MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses
- Author
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Devine, Jay, primary, Vidal-García, Marta, additional, Liu, Wei, additional, Neves, Amanda, additional, Lo Vercio, Lucas D., additional, Green, Rebecca M., additional, Richbourg, Heather A., additional, Marchini, Marta, additional, Unger, Colton M., additional, Nickle, Audrey C., additional, Radford, Bethany, additional, Young, Nathan M., additional, Gonzalez, Paula N., additional, Schuler, Robert E., additional, Bugacov, Alejandro, additional, Rolian, Campbell, additional, Percival, Christopher J., additional, Williams, Trevor, additional, Niswander, Lee, additional, Calof, Anne L., additional, Lander, Arthur D., additional, Visel, Axel, additional, Jirik, Frank R., additional, Cheverud, James M., additional, Klein, Ophir D., additional, Birnbaum, Ramon Y., additional, Merrill, Amy E., additional, Ackermann, Rebecca R., additional, Graf, Daniel, additional, Hemberger, Myriam, additional, Dean, Wendy, additional, Forkert, Nils D., additional, Murray, Stephen A., additional, Westerberg, Henrik, additional, Marcucio, Ralph S., additional, and Hallgrímsson, Benedikt, additional
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- 2023
- Full Text
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15. ICARUS at the Fermilab Short-Baseline Neutrino program: initial operation
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Abratenko, P., primary, Aduszkiewicz, A., additional, Akbar, F., additional, Pons, M. Artero, additional, Asaadi, J., additional, Aslin, M., additional, Babicz, M., additional, Badgett, W. F., additional, Bagby, L. F., additional, Baibussinov, B., additional, Behera, B., additional, Bellini, V., additional, Beltramello, O., additional, Benocci, R., additional, Berger, J., additional, Berkman, S., additional, Bertolucci, S., additional, Bertoni, R., additional, Betancourt, M., additional, Bettini, M., additional, Biagi, S., additional, Biery, K., additional, Bitter, O., additional, Bonesini, M., additional, Boone, T., additional, Bottino, B., additional, Braggiotti, A., additional, Brailsford, D., additional, Bremer, J., additional, Brice, S. J., additional, Brio, V., additional, Brizzolari, C., additional, Brown, J., additional, Budd, H. S., additional, Calaon, F., additional, Campani, A., additional, Carber, D., additional, Carneiro, M., additional, Terrazas, I. Caro, additional, Carranza, H., additional, Casazza, D., additional, Castellani, L., additional, Castro, A., additional, Centro, S., additional, Cerati, G., additional, Chalifour, M., additional, Chambouvet, P., additional, Chatterjee, A., additional, Cherdack, D., additional, Cherubini, S., additional, Chithirasreemadam, N., additional, Cicerchia, M., additional, Cicero, V., additional, Coan, T., additional, Cocco, A. G., additional, Convery, M. R., additional, Copello, S., additional, Cristaldo, E., additional, Dange, A. A., additional, de Icaza Astiz, I., additional, De Roeck, A., additional, Di Domizio, S., additional, Di Noto, L., additional, Di Stefano, C., additional, Di Ferdinando, D., additional, Diwan, M., additional, Dolan, S., additional, Domine, L., additional, Donati, S., additional, Doubnik, R., additional, Drielsma, F., additional, Dyer, J., additional, Dytman, S., additional, Fabre, C., additional, Fabris, F., additional, Falcone, A., additional, Farnese, C., additional, Fava, A., additional, Ferguson, H., additional, Ferrari, A., additional, Ferraro, F., additional, Gallice, N., additional, Garcia, F. G., additional, Geynisman, M., additional, Giarin, M., additional, Gibin, D., additional, Gigli, S. G., additional, Gioiosa, A., additional, Gu, W., additional, Guerzoni, M., additional, Guglielmi, A., additional, Gurung, G., additional, Hahn, S., additional, Hardin, K., additional, Hausner, H., additional, Heggestuen, A., additional, Hilgenberg, C., additional, Hogan, M., additional, Howard, B., additional, Howell, R., additional, Hrivnak, J., additional, Iliescu, M., additional, Ingratta, G., additional, James, C., additional, Jang, W., additional, Jung, M., additional, Jwa, Y.-J., additional, Kashur, L., additional, Ketchum, W., additional, Kim, J. S., additional, Koh, D.-H., additional, Kose, U., additional, Larkin, J., additional, Laurenti, G., additional, Lukhanin, G., additional, Marchini, S., additional, Marshall, C. M., additional, Martynenko, S., additional, Mauri, N., additional, Mazzacane, A., additional, McFarland, K. S., additional, Méndez, D. P., additional, Menegolli, A., additional, Meng, G., additional, Miranda, O. G., additional, Mladenov, D., additional, Mogan, A., additional, Moggi, N., additional, Montagna, E., additional, Montanari, C., additional, Montanari, A., additional, Mooney, M., additional, Moreno-Granados, G., additional, Mueller, J., additional, Naples, D., additional, Nebot-Guinot, M., additional, Nessi, M., additional, Nichols, T., additional, Nicoletto, M., additional, Norris, B., additional, Palestini, S., additional, Pallavicini, M., additional, Paolone, V., additional, Papaleo, R., additional, Pasqualini, L., additional, Patrizii, L., additional, Peghin, R., additional, Petrillo, G., additional, Petta, C., additional, Pia, V., additional, Pietropaolo, F., additional, Poirot, J., additional, Poppi, F., additional, Pozzato, M., additional, Prata, M. C., additional, Prosser, A., additional, Putnam, G., additional, Qian, X., additional, Rampazzo, G., additional, Rappoldi, A., additional, Raselli, G. L., additional, Rechenmacher, R., additional, Resnati, F., additional, Ricci, A. M., additional, Riccobene, G., additional, Rice, L., additional, Richards, E., additional, Rigamonti, A., additional, Rosenberg, M., additional, Rossella, M., additional, Rubbia, C., additional, Sala, P., additional, Sapienza, P., additional, Savage, G., additional, Scaramelli, A., additional, Scarpelli, A., additional, Schmitz, D., additional, Schukraft, A., additional, Sergiampietri, F., additional, Sirri, G., additional, Smedley, J. S., additional, Soha, A. K., additional, Spanu, M., additional, Stanco, L., additional, Stewart, J., additional, Suarez, N. B., additional, Sutera, C., additional, Tanaka, H. A., additional, Tenti, M., additional, Terao, K., additional, Terranova, F., additional, Togo, V., additional, Torretta, D., additional, Torti, M., additional, Tortorici, F., additional, Tosi, N., additional, Tsai, Y.-T., additional, Tufanli, S., additional, Turcato, M., additional, Usher, T., additional, Varanini, F., additional, Ventura, S., additional, Vercellati, F., additional, Vicenzi, M., additional, Vignoli, C., additional, Viren, B., additional, Warner, D., additional, Williams, Z., additional, Wilson, R. J., additional, Wilson, P., additional, Wolfs, J., additional, Wongjirad, T., additional, Wood, A., additional, Worcester, E., additional, Worcester, M., additional, Wospakrik, M., additional, Yu, H., additional, Yu, J., additional, Zani, A., additional, Zatti, P. G., additional, Zennamo, J., additional, Zettlemoyer, J. C., additional, Zhang, C., additional, Zucchelli, S., additional, and Zuckerbrot, M., additional
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- 2023
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16. Rapid quasi-periodic oscillations in the relativistic jet of BL Lacertae
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S. G. Jorstad, A. P. Marscher, C. M. Raiteri, M. Villata, Z. R. Weaver, H. Zhang, L. Dong, J. L. Gómez, M. V. Perel, S. S. Savchenko, V. M. Larionov, D. Carosati, W. P. Chen, O. M. Kurtanidze, A. Marchini, K. Matsumoto, F. Mortari, P. Aceti, J. A. Acosta-Pulido, T. Andreeva, G. Apolonio, C. Arena, A. Arkharov, R. Bachev, M. Banfi, G. Bonnoli, G. A. Borman, V. Bozhilov, M. I. Carnerero, G. Damljanovic, S. A. Ehgamberdiev, D. Elsässer, A. Frasca, D. Gabellini, T. S. Grishina, A. C. Gupta, V. A. Hagen-Thorn, M. K. Hallum, M. Hart, K. Hasuda, F. Hemrich, H. Y. Hsiao, S. Ibryamov, T. R. Irsmambetova, D. V. Ivanov, M. D. Joner, G. N. Kimeridze, S. A. Klimanov, J. Knött, E. N. Kopatskaya, S. O. Kurtanidze, A. Kurtenkov, T. Kuutma, E. G. Larionova, S. Leonini, H. C. Lin, C. Lorey, K. Mannheim, G. Marino, M. Minev, D. O. Mirzaqulov, D. A. Morozova, A. A. Nikiforova, M. G. Nikolashvili, E. Ovcharov, R. Papini, T. Pursimo, I. Rahimov, D. Reinhart, T. Sakamoto, F. Salvaggio, E. Semkov, D. N. Shakhovskoy, L. A. Sigua, R. Steineke, M. Stojanovic, A. Strigachev, Y. V. Troitskaya, I. S. Troitskiy, A. Tsai, A. Valcheva, A. A. Vasilyev, O. Vince, L. Waller, E. Zaharieva, R. Chatterjee, Ministerio de Ciencia e Innovación (España), and European Commission
- Subjects
High-energy astrophysics ,Multidisciplinary ,Astrophysical magnetic fields, High-energy astrophysics, Time-domain astronomy ,Time-domain astronomy ,Astrophysical magnetic fields - Abstract
Full list of authors: Jorstad, S. G.; Marscher, A. P.; Raiteri, C. M.; Villata, M.; Weaver, Z. R.; Zhang, H.; Dong, L.; Gomez, J. L.; Perel, M., V; Savchenko, S. S.; Larionov, V. M.; Carosati, D.; Chen, W. P.; Kurtanidze, O. M.; Marchini, A.; Matsumoto, K.; Mortari, F.; Aceti, P.; Acosta-Pulido, J. A.; Andreeva, T.; Apolonio, G.; Arena, C.; Arkharov, A.; Bachev, R.; Bonnoli, G.; Borman, G. A.; Bozhilov, V; Carnerero, M., I; Damljanovic, G.; Ehgamberdiev, S. A.; Elsasser, D.; Frasca, A.; Gabellini, D.; Grishina, T. S.; Gupta, A. C.; Hagen-Thorn, V. A.; Hallum, M. K.; Hart, M.; Hasuda, K.; Hemrich, F.; Hsiao, H. Y.; Ibryamov, S.; Irsmambetova, T. R.; Ivanov, D., V; Joner, M. D.; Kimeridze, G. N.; Klimanov, S. A.; Knoett, J.; Kopatskaya, E. N.; Kurtanidze, S. O.; Kurtenkov, A.; Kuutma, T.; Larionova, E. G.; Leonini, S.; Lin, H. C.; Lorey, C.; Mannheim, K.; Marino, G.; Minev, M.; Mirzaqulov, D. O.; Morozova, D. A.; Nikiforova, A. A.; Nikolashvili, M. G.; Ovcharov, E.; Papini, R.; Pursimo, T.; Rahimov, I; Reinhart, D.; Sakamoto, T.; Salvaggio, F.; Semkov, E.; Shakhovskoy, D. N.; Sigua, L. A.; Steineke, R.; Stojanovic, M.; Strigachev, A.; Troitskaya, Y., V; Troitskiy, I. S.; Tsai, A.; Valcheva, A.; Vasilyev, A. A.; Vince, O.; Waller, L.; Zaharieva, E.; Chatterjee, R., Blazars are active galactic nuclei (AGN) with relativistic jets whose non-thermal radiation is extremely variable on various timescales1,2,3. This variability seems mostly random, although some quasi-periodic oscillations (QPOs), implying systematic processes, have been reported in blazars and other AGN. QPOs with timescales of days or hours are especially rare4 in AGN and their nature is highly debated, explained by emitting plasma moving helically inside the jet5, plasma instabilities6,7 or orbital motion in an accretion disc7,8. Here we report results of intense optical and γ-ray flux monitoring of BL Lacertae (BL Lac) during a dramatic outburst in 2020 (ref. 9). BL Lac, the prototype of a subclass of blazars10, is powered by a 1.7 × 108 MSun (ref. 11) black hole in an elliptical galaxy (distance = 313 megaparsecs (ref. 12)). Our observations show QPOs of optical flux and linear polarization, and γ-ray flux, with cycles as short as approximately 13 h during the highest state of the outburst. The QPO properties match the expectations of current-driven kink instabilities6 near a recollimation shock about 5 parsecs (pc) from the black hole in the wake of an apparent superluminal feature moving down the jet. Such a kink is apparent in a microwave Very Long Baseline Array (VLBA) image. © 2022 Springer Nature Limited., The research reported here is based on work supported in part by US National Science Foundation grants AST-2108622 and AST-2107806, and NASA Fermi GI grants 80NSSC20K1567, 80NSSC21K1917 and 80NSSC21K1951; by Shota Rustaveli National Science Foundation of Georgia under contract FR-19-6174; by the Bulgarian National Science Fund of the Ministry of Education and Science under grants DN 18-10/2017, DN 18-13/2017, KP-06-H28/3 (2018), KP-06-H38/4 (2019) and KP-06-KITAJ/2 (2020), and by National RI Roadmap Project D01-383/18.12.2020 of the Ministry of Education and Science of the Republic of Bulgaria; by JSPS KAKENHI grant #19K03930 of Japan; by the Ministry of Education, Science and Technological Development of the Republic of Serbia (contract 451-03-9/2021-14/200002) and observing grant support from the Institute of Astronomy and Rozhen NAO BAS through the bilateral joint research project ‘Gaia Celestial Reference Frame (CRF) and fast variable astronomical objects’; by the Agenzia Spaziale Italiana (ASI) through contracts I/037/08/0, I/058/10/0, 2014-025-R.0, 2014-025-R.1.2015 and 2018-24-HH.0 to the Italian Istituto Nazionale di Astrofisica (INAF). H.Z. is supported by the NASA Postdoctoral Program at Goddard Space Flight Center, administered by ORAU. M.V.P. is partially supported by the Russian Foundation for Basic Research grant 20-02-00490. G.B. acknowledges support from the State Agency for Research of the Spanish MCIU through the ‘Center of Excellence Severo Ochoa’ award to the Instituto de Astrofísica de Andalucía (SEV-2017-0709) and from the Spanish ‘Ministerio de Ciencia e Innovacíon’ (MICINN) through grant PID2019-107847RB-C44. M.D.J. thanks the Brigham Young University Department of Physics and Astronomy for continued support of the extragalactic monitoring programme under way at the West Mountain Observatory. R.C. thanks ISRO for support under the AstroSat archival data utilization programme and BRNS for support through a project grant (sanction no. 57/14/10/2019-BRNS). The measurements at the Hans Haffner Observatory, Hettstadt, Germany, were supported by Baader Planetarium, Mammendorf, Germany. This study was based (in part) on observations conducted using the 1.8-m Perkins Telescope Observatory (PTO) in Arizona, USA, which is owned and operated by Boston University. These results made use of the Lowell Discovery Telescope (LDT) at Lowell Observatory. Lowell Observatory is a private, non-profit institution dedicated to astrophysical research and public appreciation of astronomy, and operates the LDT in partnership with Boston University, the University of Maryland and the University of Toledo. This paper is partly based on observations made with the IAC-80 operated on the island of Tenerife by the Instituto de Astrofisica de Canarias in the Spanish Observatorio del Teide and on observations made with the LCOGT telescopes, one of whose nodes is located at the Observatorios de Canarias del IAC on the island of Tenerife in the Observatorio del Teide. This paper is partly based on observations made with the Nordic Optical Telescope, owned in collaboration by the University of Turku and Aarhus University, and operated jointly by Aarhus University, the University of Turku and the University of Oslo, representing Denmark, Finland and Norway, the University of Iceland and Stockholm University at the Observatorio del Roque de los Muchachos, La Palma, Spain, of the Instituto de Astrofisica de Canarias. The VLBA is an instrument of the NRAO, USA. The NRAO is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc.
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- 2022
17. Impact of trans-stent gradient on outcome after PCI: results from a HAWKEYE substudy
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Andrea Erriquez, Barry F. Uretsky, Salvatore Brugaletta, Giosafat Spitaleri, Enrico Cerrato, Giorgio Quadri, Marco Manfrini, Graziella Pompei, Davide Scancarello, Michele Trichilo, Federico Marchini, Serena Caglioni, Roberta Campana, Andrea Marrone, Carlo Penzo, Carlo Tumscitz, Matteo Tebaldi, Filippo Maria Verardi, Antonella Scala, Gianluca Campo, and Simone Biscaglia
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Percutaneous Coronary Intervention ,ROC Curve ,Predictive Value of Tests ,Area Under Curve ,Humans ,Stents - Abstract
To test whether quantitative flow ratio (QFR)-based trans-stent gradient (TSG) is associated with adverse clinical events at follow-up. A post-hoc analysis of the multi-center HAWKEYE study was performed. Vessels post-PCI were divided into four groups (G) as follows: G1: QFR ≥ 0.90 TSG = 0 (n = 412, 54.8%); G2: QFR ≥ 0.90, TSG > 0 (n = 216, 28.7%); G3: QFR 0 (n = 86, 11.4%). Cox proportional hazards regression model was used to analyze the effect of baseline and prognostic variables. The final reduced model was obtained by backward stepwise variable selection. Receiver operating characteristic (ROC) was plotted and area under the curve (AUC) was calculated and reported. Overall, 449 (59.8%) vessels had a TSG = 0 whereas (40.2%) had TSG > 0. Ten (2.2%) vessel-oriented composite endpoint (VOCE) occurred in vessels with TSG = 0, compared with 43 (14%) in vessels with TSG > 0 (p 0 was an independent predictor of the VOCE (HR 2.95 [95% CI 1.77–4.91]). The combination of higher TSG and lower final QFR (G4) showed the worst long-term outcome while low TSG and high QFR showed the best outcome (G1) while either high TSG or low QFR (G2, G3) showed intermediate and comparable outcomes. Higher trans-stent gradient was an independent predictor of adverse events and identified a subgroup of patients at higher risk for poor outcomes even when vessel QFR was optimal (> 0.90).
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- 2022
18. Correction to: Expert Consensus on the Use of the PRESERFLO™ MicroShunt Device in the Treatment of Glaucoma: A Modified Delphi Panel
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Anthony P. Khawaja, Ingeborg Stalmans, Florent Aptel, Keith Barton, Henny Beckers, Thomas Klink, Giorgio Marchini, Jose Martínez de la Casa, Jan H. Simonsen, Marc Töteberg-Harms, Clemens Vass, and Luís Abegão Pinto
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Ophthalmology - Published
- 2022
19. Autologous simple conjunctival epithelial transplantation for primary pterygium
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Emilio Pedrotti, Marina Bertolin, Adriano Fasolo, Erika Bonacci, Francesca Bosello, Diego Ponzin, and Giorgio Marchini
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Ophthalmology ,Simple conjunctival epithelial transplantation ,Conjunctival surgery ,Recurrence ,Primary pterygium ,Humans ,Adjuvant treatment ,Pterygium ,Conjunctiva ,Transplantation, Autologous ,Follow-Up Studies - Abstract
To evaluate the feasibility of a new method of conjunctival transplantation to achieve recovery of the normal conjunctival epithelium over the bare sclera after pterygium excision and prevent its recurrence.After excision of the primary pterygium, we performed simple conjunctival epithelial transplantation (SCET) in which we glued an amniotic membrane patch pre-loaded with tiny autologous conjunctival tissue fragments over the scleral defect. Slit-lamp evaluation was performed at 2 and 7-10 days, and then at 1, 3, 6, and 12 months after surgery, together with confocal microscopy at 3, 6, and 12 months.Surgical excision and SCET for nasal primary pterygium were performed in 6 eyes (6 patients). No graft detachment occurred. An inflammatory granuloma was excised without sequelae in one patient 2 months after surgery. No signs of recurrence or sight-threatening complications were recorded at 12 months, and in vivo confocal microscopy showed progressive expansion of the conjunctival cell population and formation of a clear corneal-conjunctival transition.SCET takes advantage of the ability of the amniotic membrane and conjunctival cells to renew. Outcomes after SCET are comparable to conventional conjunctival flap surgery and can be achieved in less surgical time and with less donor tissue to be removed.
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- 2022
20. Empathy levels among health professional students at a large midwestern public university - a cross-sectional study
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Wenger, Kelsey, primary, Reist, Lauren, additional, Achenbach, Andrea, additional, Dukes, Kimberly, additional, Fravel, Michelle, additional, Knockel, Laura, additional, Kuehnle, Francis, additional, Reist, Jeffrey, additional, Suneja, Manish, additional, Pendleton, Chandler, additional, Xie, Xian Jin, additional, and Marchini, Leonardo, additional
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- 2023
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- View/download PDF
21. Association of appropriateness for ICU admission with resource use, organ support and long-term survival in critically ill cancer patients
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Silva, Carla Marchini Dias, primary, Germano, Janaina Naiara, additional, Costa, Anna Karolyne de Araujo, additional, Gennari, Giovanna Alves, additional, Caruso, Pedro, additional, and Nassar Jr, Antonio Paulo, additional
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- 2023
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22. Empathy levels among health professional students at a large midwestern public university - a cross-sectional study
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Kelsey Wenger, Lauren Reist, Andrea Achenbach, Kimberly Dukes, Michelle Fravel, Laura Knockel, Francis Kuehnle, Jeffrey Reist, Manish Suneja, Chandler Pendleton, Xian Jin Xie, and Leonardo Marchini
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General Medicine ,Education - Abstract
Background Empathic care is considered extremely important by patients and providers alike but there is still an ample need for assessing empathy among healthcare students and professionals and identifying appropriate educational interventions to improve it. This study aims to assess empathy levels and associated factors among students at different healthcare colleges at the University of Iowa. Methods An online survey was delivered to healthcare students, including nursing, pharmacy, dental, and medical colleges (IRB ID #202,003,636). The cross-sectional survey included background questions, probing questions, college-specific questions, and the Jefferson Scale of Empathy-Health Professionals Student version (JSPE-HPS). To examine bivariate associations, Kruskal Wallis and Wilcoxon rank sum tests were used. A linear model with no transformation was used in the multivariable analysis. Results Three hundred students responded to the survey. Overall JSPE-HPS score was 116 (± 11.7), consistent with other healthcare professional samples. There was no significant difference in JSPE-HPS score among the different colleges (P = 0.532). Conclusion Controlling for other variables in the linear model, healthcare students’ view of their faculty’s empathy toward patients and students’ self-reported empathy levels were significantly associated with students’ JSPE-HPS scores.
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- 2023
23. Association of appropriateness for ICU admission with resource use, organ support and long-term survival in critically ill cancer patients
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Carla Marchini Dias Silva, Janaina Naiara Germano, Anna Karolyne de Araujo Costa, Giovanna Alves Gennari, Pedro Caruso, and Antonio Paulo Nassar Jr
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Emergency Medicine ,Internal Medicine - Published
- 2023
24. Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc
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Bellocchi, Chiara, primary, Assassi, Shervin, additional, Lyons, Marka, additional, Marchini, Maurizio, additional, Mohan, Chandra, additional, Santaniello, Alessandro, additional, and Beretta, Lorenzo, additional
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- 2023
- Full Text
- View/download PDF
25. Acclimatization of a coral-dinoflagellate mutualism at a CO2 vent
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Prada, Fiorella, primary, Franzellitti, Silvia, additional, Caroselli, Erik, additional, Cohen, Itay, additional, Marini, Mauro, additional, Campanelli, Alessandra, additional, Sana, Lorenzo, additional, Mancuso, Arianna, additional, Marchini, Chiara, additional, Puglisi, Alessia, additional, Candela, Marco, additional, Mass, Tali, additional, Tassi, Franco, additional, LaJeunesse, Todd C., additional, Dubinsky, Zvy, additional, Falini, Giuseppe, additional, and Goffredo, Stefano, additional
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- 2023
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26. The chronicles of a small invader: the canal, the core and the tsunami
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Mancin, N., primary, Guastella, R., additional, Carlton, J. T., additional, Caruso, A., additional, Cobianchi, M., additional, Evans, J., additional, Capotondi, L., additional, Langone, L., additional, and Marchini, A., additional
- Published
- 2022
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27. Second-order necessary conditions in optimal control of evolution systems
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Frankowska, H., primary, Marchini, E. M., additional, and Mazzola, M., additional
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- 2022
- Full Text
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28. Polarized blazar X-rays imply particle acceleration in shocks
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Liodakis, Ioannis, primary, Marscher, Alan P., additional, Agudo, Iván, additional, Berdyugin, Andrei V., additional, Bernardos, Maria I., additional, Bonnoli, Giacomo, additional, Borman, George A., additional, Casadio, Carolina, additional, Casanova, Vı́ctor, additional, Cavazzuti, Elisabetta, additional, Rodriguez Cavero, Nicole, additional, Di Gesu, Laura, additional, Di Lalla, Niccoló, additional, Donnarumma, Immacolata, additional, Ehlert, Steven R., additional, Errando, Manel, additional, Escudero, Juan, additional, Garcı́a-Comas, Maya, additional, Agı́s-González, Beatriz, additional, Husillos, César, additional, Jormanainen, Jenni, additional, Jorstad, Svetlana G., additional, Kagitani, Masato, additional, Kopatskaya, Evgenia N., additional, Kravtsov, Vadim, additional, Krawczynski, Henric, additional, Lindfors, Elina, additional, Larionova, Elena G., additional, Madejski, Grzegorz M., additional, Marin, Frédéric, additional, Marchini, Alessandro, additional, Marshall, Herman L., additional, Morozova, Daria A., additional, Massaro, Francesco, additional, Masiero, Joseph R., additional, Mawet, Dimitri, additional, Middei, Riccardo, additional, Millar-Blanchaer, Maxwell A., additional, Myserlis, Ioannis, additional, Negro, Michela, additional, Nilsson, Kari, additional, O’Dell, Stephen L., additional, Omodei, Nicola, additional, Pacciani, Luigi, additional, Paggi, Alessandro, additional, Panopoulou, Georgia V., additional, Peirson, Abel L., additional, Perri, Matteo, additional, Petrucci, Pierre-Olivier, additional, Poutanen, Juri, additional, Puccetti, Simonetta, additional, Romani, Roger W., additional, Sakanoi, Takeshi, additional, Savchenko, Sergey S., additional, Sota, Alfredo, additional, Tavecchio, Fabrizio, additional, Tinyanont, Samaporn, additional, Vasilyev, Andrey A., additional, Weaver, Zachary R., additional, Zhovtan, Alexey V., additional, Antonelli, Lucio A., additional, Bachetti, Matteo, additional, Baldini, Luca, additional, Baumgartner, Wayne H., additional, Bellazzini, Ronaldo, additional, Bianchi, Stefano, additional, Bongiorno, Stephen D., additional, Bonino, Raffaella, additional, Brez, Alessandro, additional, Bucciantini, Niccoló, additional, Capitanio, Fiamma, additional, Castellano, Simone, additional, Ciprini, Stefano, additional, Costa, Enrico, additional, De Rosa, Alessandra, additional, Del Monte, Ettore, additional, Di Marco, Alessandro, additional, Doroshenko, Victor, additional, Dovčiak, Michal, additional, Enoto, Teruaki, additional, Evangelista, Yuri, additional, Fabiani, Sergio, additional, Ferrazzoli, Riccardo, additional, Garcia, Javier A., additional, Gunji, Shuichi, additional, Hayashida, Kiyoshi, additional, Heyl, Jeremy, additional, Iwakiri, Wataru, additional, Karas, Vladimir, additional, Kitaguchi, Takao, additional, Kolodziejczak, Jeffery J., additional, La Monaca, Fabio, additional, Latronico, Luca, additional, Maldera, Simone, additional, Manfreda, Alberto, additional, Marinucci, Andrea, additional, Matt, Giorgio, additional, Mitsuishi, Ikuyuki, additional, Mizuno, Tsunefumi, additional, Muleri, Fabio, additional, Ng, Stephen C.-Y., additional, Oppedisano, Chiara, additional, Papitto, Alessandro, additional, Pavlov, George G., additional, Pesce-Rollins, Melissa, additional, Pilia, Maura, additional, Possenti, Andrea, additional, Ramsey, Brian D., additional, Rankin, John, additional, Ratheesh, Ajay, additional, Sgró, Carmelo, additional, Slane, Patrick, additional, Soffitta, Paolo, additional, Spandre, Gloria, additional, Tamagawa, Toru, additional, Taverna, Roberto, additional, Tawara, Yuzuru, additional, Tennant, Allyn F., additional, Thomas, Nicolas E., additional, Tombesi, Francesco, additional, Trois, Alessio, additional, Tsygankov, Sergey, additional, Turolla, Roberto, additional, Vink, Jacco, additional, Weisskopf, Martin C., additional, Wu, Kinwah, additional, Xie, Fei, additional, and Zane, Silvia, additional
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- 2022
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29. Universal clinical Parkinson’s disease axes identify a major influence of neuroinflammation
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Sandor, Cynthia, primary, Millin, Stephanie, additional, Dahl, Andrew, additional, Schalkamp, Ann-Kathrin, additional, Lawton, Michael, additional, Hubbard, Leon, additional, Rahman, Nabila, additional, Williams, Nigel, additional, Ben-Shlomo, Yoav, additional, Grosset, Donald G., additional, Hu, Michele T., additional, Marchini, Jonathan, additional, and Webber, Caleb, additional
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- 2022
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30. A wicked environmental challenge: collaboration network for free-ranging dog management in an urban environment
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Mohammadi, Alireza, primary, Nayeri, Danial, additional, Alambeigi, Amir, additional, and Marchini, Silvio, additional
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- 2022
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31. Proteomic aptamer analysis reveals serum markers that characterize preclinical systemic sclerosis (SSc) patients at risk for progression toward definite SSc
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Chiara Bellocchi, Shervin Assassi, Marka Lyons, Maurizio Marchini, Chandra Mohan, Alessandro Santaniello, and Lorenzo Beretta
- Abstract
Background The study of molecular mechanisms characterizing disease progression may be relevant to get insights into systemic sclerosis (SSc) pathogenesis and to intercept patients at very early stage. We aimed at investigating the proteomic profile of preclinical systemic sclerosis (PreSSc) via a discovery/validation two-step approach. Methods SOMAcan aptamer-based analysis was performed on a serum sample of 13 PreSSc (discovery cohort) according to 2001 LeRoy and Medsger criteria (characterized solely by Raynaud phenomenon plus a positive nailfold capillaroscopy and SSc-specific antibodies without any other sign of definite disease) and 8 healthy controls (HCs) age, gender, and ethnicity matched. Prospective data were available up to 4±0.6 years to determine the progression to definite SSc according to the EULAR/ACR 2013 classification criteria. In proteins with relative fluorescence units (RFU) > |1.5|-fold vs HCs values, univariate analysis was conducted via bootstrap aggregating models to determine the predicting accuracy (progression vs non-progression) of categorized baseline protein values. Gene Ontologies (GO terms) and Reactome terms of significant proteins at the adjusted 0.05 threshold were explored. Significant proteins from the discovery cohort were finally validated via ELISAs in an independent validation cohort of 50 PreSSc with clinical prospective data up to 5 years. Time-to-event analysis for interval-censored data was used to evaluate disease progression. Results In the discovery cohort, 286 out of 1306 proteins analyzed via SomaScan, were differentially expressed versus HCs. Ten proteins were significantly associated with disease progression; analysis through GO and Reactome showed differentially enriched pathways involving angiogenesis, endothelial cell chemotaxis, and endothelial cell chemotaxis to fibroblast growth factor (FGF). In the validation cohort, endostatin (HR=10.23, CI95=2.2–47.59, p=0.003) was strongly associated with disease progression, as well as bFGF (HR=0.84, CI95=0.709-0.996, p=0.045) and PAF-AHβ (HR=0.372, CI95=0.171–0.809, p=0.013) Conclusions A distinct protein profile characterized PreSSc from HCs and proteins associated with hypoxia, vasculopathy, and fibrosis regulation are linked with the progression from preclinical to definite SSc. These proteins, in particular endostatin, can be regarded both as markers of severity and molecules with pathogenetic significance as well as therapeutic targets.
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- 2023
32. Second-order necessary conditions in optimal control of evolution systems
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H. Frankowska, E. M. Marchini, and M. Mazzola
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Normality ,Mathematics (miscellaneous) ,Semilinear control system, State constraint, Optimal control, Second-order necessary condi- tions, Normality ,Semilinear control system ,State constraint ,Second-order necessary condi- tions ,Optimal control - Published
- 2022
33. 3D morphometric evaluation of the dental arches in children with cleft lip and palate submitted to different surgical techniques
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Paula Karine Jorge, Simone Soares, Fabrício Pinelli Valarelli, Maria Aparecida de Andrade Moreira Machado, Chiarella Sforza, Cleide Felício de Carvalho Carrara, Eloá Cristina Passucci Ambrosio, Thais Marchini de Oliveira, Marcio De Menezes, and Maiara Miyuki Matsui Falzoni
- Subjects
Orthodontics ,business.industry ,Intraclass correlation ,Cleft Lip ,medicine.medical_treatment ,Infant ,Dental Models ,Unilateral complete cleft lip ,Cleft Palate ,Dental arch ,Dental Arch ,medicine.anatomical_structure ,Palatoplasty ,Maxilla ,medicine ,Humans ,CIRURGIA PLÁSTICA ,Cheiloplasty ,Arch ,Child ,business ,General Dentistry - Abstract
Objectives This study aimed to compare dimensional alterations of dental arches in children with unilateral complete cleft lip and palate before and after different techniques of primary plastic surgeries. Materials and methods The sample was divided into two groups: group 1-cheiloplasty by Millard's technique and one-stage palatoplasty by von Langenbeck's technique; group 2-cheiloplasty by Millard's technique and two-stage palatoplasty: anterior palatoplasty by Hans Pichler's technique and posterior palatoplasty by Sommerlad's technique. Dental arches were evaluated before (T1), after the first phase (T2), and 1 year after the second phase (T3) of primary surgeries. Linear measurements and palatal area were assessed. To analyze the method's error, interclass correlation coefficient was applied. ANOVA (followed by Tukey test), dependent, and independent t-test were used (p Results At T1, the intertuberosity distance was statistically greater in G2 (p = 0.004). At T2, the anterior length of the dental arch was statistically greater in G2 (p = 0.025), while the area of the smaller palatal segment (p = 0.001), cleft area (p = 0.014), and total area (p = 0.002) were statistically smaller in G2. At T3, the intertuberosity distance was statistically greater in G2 (p = 0.017). Conclusion This study suggests that cheiloplasty and one-stage palatoplasty resulted in smaller growth of maxilla than cheiloplasty and two-stage palatoplasty in the linear measurements (T-T' and I-CC') and total area of the dental arches. Clinical relevance Surgical protocols need to be evaluated to verify their effects aiming at improving the clinical practice of the interdisciplinary team, determining new parameters for the rehabilitation of individuals with cleft lip and palate.
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- 2021
34. Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes
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Akbari, Parsa, Sosina, Olukayode A., Bovijn, Jonas, Landheer, Karl, Nielsen, Jonas B., Kim, Minhee, Aykul, Senem, De, Tanima, Haas, Mary E., Hindy, George, Lin, Nan, Dinsmore, Ian R., Luo, Jonathan Z., Hectors, Stefanie, Geraghty, Benjamin, Germino, Mary, Panagis, Lampros, Parasoglou, Prodromos, Walls, Johnathon R., Halasz, Gabor, Atwal, Gurinder S., Della Gatta, Giusy, Jones, Marcus, LeBlanc, Michelle G., Still, Christopher D., Carey, David J., Giontella, Alice, Orho-Melander, Marju, Berumen, Jaime, Kuri-Morales, Pablo, Alegre-Díaz, Jesus, Torres, Jason M., Emberson, Jonathan R., Collins, Rory, Rader, Daniel J., Zambrowicz, Brian, Murphy, Andrew J., Balasubramanian, Suganthi, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan R., Cantor, Michael, Abecasis, Goncalo R., Ferreira, Manuel A. R., Sleeman, Mark W., Gusarova, Viktoria, Altarejos, Judith, Harris, Charles, Economides, Aris N., Idone, Vincent, Karalis, Katia, Mirshahi, Tooraj, Yancopoulos, George D., Melander, Olle, Marchini, Jonathan, Tapia-Conyer, Roberto, Locke, Adam E., Baras, Aris, Verweij, Niek, and Lotta, Luca A.
- Subjects
Multidisciplinary ,Adipose Tissue ,Diabetes Mellitus, Type 2 ,Mutation ,Humans ,General Physics and Astronomy ,Exome ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology ,Adiposity ,Inhibin-beta Subunits - Abstract
Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 non-Europeans) from the UK, Sweden and Mexico, we identify 16 genes associated with fat distribution at exome-wide significance. We show 6-fold larger effect for fat-distribution associated rare coding variants compared with fine-mapped common alleles, enrichment for genes expressed in adipose tissue and causal genes for partial lipodystrophies, and evidence of sex-dimorphism. We describe an association with favorable fat distribution (p = 1.8 × 10−09), favorable metabolic profile and protection from type 2 diabetes (~28% lower odds; p = 0.004) for heterozygous protein-truncating mutations in INHBE, which encodes a circulating growth factor of the activin family, highly and specifically expressed in hepatocytes. Our results suggest that inhibin βE is a liver-expressed negative regulator of adipose storage whose blockade may be beneficial in fat distribution-associated metabolic disease.
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- 2022
35. Rapid quasi-periodic oscillations in the relativistic jet of BL Lacertae
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Jorstad, S. G., primary, Marscher, A. P., additional, Raiteri, C. M., additional, Villata, M., additional, Weaver, Z. R., additional, Zhang, H., additional, Dong, L., additional, Gómez, J. L., additional, Perel, M. V., additional, Savchenko, S. S., additional, Larionov, V. M., additional, Carosati, D., additional, Chen, W. P., additional, Kurtanidze, O. M., additional, Marchini, A., additional, Matsumoto, K., additional, Mortari, F., additional, Aceti, P., additional, Acosta-Pulido, J. A., additional, Andreeva, T., additional, Apolonio, G., additional, Arena, C., additional, Arkharov, A., additional, Bachev, R., additional, Banfi, M., additional, Bonnoli, G., additional, Borman, G. A., additional, Bozhilov, V., additional, Carnerero, M. I., additional, Damljanovic, G., additional, Ehgamberdiev, S. A., additional, Elsässer, D., additional, Frasca, A., additional, Gabellini, D., additional, Grishina, T. S., additional, Gupta, A. C., additional, Hagen-Thorn, V. A., additional, Hallum, M. K., additional, Hart, M., additional, Hasuda, K., additional, Hemrich, F., additional, Hsiao, H. Y., additional, Ibryamov, S., additional, Irsmambetova, T. R., additional, Ivanov, D. V., additional, Joner, M. D., additional, Kimeridze, G. N., additional, Klimanov, S. A., additional, Knött, J., additional, Kopatskaya, E. N., additional, Kurtanidze, S. O., additional, Kurtenkov, A., additional, Kuutma, T., additional, Larionova, E. G., additional, Leonini, S., additional, Lin, H. C., additional, Lorey, C., additional, Mannheim, K., additional, Marino, G., additional, Minev, M., additional, Mirzaqulov, D. O., additional, Morozova, D. A., additional, Nikiforova, A. A., additional, Nikolashvili, M. G., additional, Ovcharov, E., additional, Papini, R., additional, Pursimo, T., additional, Rahimov, I., additional, Reinhart, D., additional, Sakamoto, T., additional, Salvaggio, F., additional, Semkov, E., additional, Shakhovskoy, D. N., additional, Sigua, L. A., additional, Steineke, R., additional, Stojanovic, M., additional, Strigachev, A., additional, Troitskaya, Y. V., additional, Troitskiy, I. S., additional, Tsai, A., additional, Valcheva, A., additional, Vasilyev, A. A., additional, Vince, O., additional, Waller, L., additional, Zaharieva, E., additional, and Chatterjee, R., additional
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- 2022
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36. Comorbidities in Friedreich ataxia: incidence and manifestations from early to advanced disease stages
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Fichera, Mario, primary, Castaldo, Anna, additional, Mongelli, Alessia, additional, Marchini, Gloria, additional, Gellera, Cinzia, additional, Nanetti, Lorenzo, additional, and Mariotti, Caterina, additional
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- 2022
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37. Impact of trans-stent gradient on outcome after PCI: results from a HAWKEYE substudy
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Erriquez, Andrea, primary, Uretsky, Barry F., additional, Brugaletta, Salvatore, additional, Spitaleri, Giosafat, additional, Cerrato, Enrico, additional, Quadri, Giorgio, additional, Manfrini, Marco, additional, Pompei, Graziella, additional, Scancarello, Davide, additional, Trichilo, Michele, additional, Marchini, Federico, additional, Caglioni, Serena, additional, Campana, Roberta, additional, Marrone, Andrea, additional, Penzo, Carlo, additional, Tumscitz, Carlo, additional, Tebaldi, Matteo, additional, Verardi, Filippo Maria, additional, Scala, Antonella, additional, Campo, Gianluca, additional, and Biscaglia, Simone, additional
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- 2022
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38. Correction to: Expert Consensus on the Use of the PRESERFLO™ MicroShunt Device in the Treatment of Glaucoma: A Modified Delphi Panel
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Khawaja, Anthony P., primary, Stalmans, Ingeborg, additional, Aptel, Florent, additional, Barton, Keith, additional, Beckers, Henny, additional, Klink, Thomas, additional, Marchini, Giorgio, additional, Martínez de la Casa, Jose, additional, Simonsen, Jan H., additional, Töteberg-Harms, Marc, additional, Vass, Clemens, additional, and Abegão Pinto, Luís, additional
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- 2022
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39. Primary congenital glaucoma surgery: outcomes and visual function
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Rosa Longo, Elia Franzolin, Francesca Chemello, Elena Gusson, Giorgio Marchini, Roberta Vesentini, and Giuseppe Verlato
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medicine.medical_specialty ,Intraocular pressure ,Visual acuity ,genetic structures ,Referral ,medicine.medical_treatment ,Visual impairment ,Trabeculectomy ,Childhood glaucoma ,Glaucoma surgery ,Axial length ,Tonometry, Ocular ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,medicine ,Humans ,Child ,Retrospective Studies ,Original Paper ,business.industry ,Medical record ,Infant, Newborn ,Glaucoma ,eye diseases ,Treatment Outcome ,Visual function ,030221 ophthalmology & optometry ,Etiology ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Purpose To assess the long-term visual outcomes of children with PCG, irrespective of the type of surgical procedure, and to create visual acuity curves to help in predicting the development of visual function in these patients. The secondary aim is to identify associated factors for visual decline or loss, highlighting differences between neonatal and infantile subgroups. Methods The medical records of pediatric glaucoma patients from 1996 to 2017 at the University Hospital of Verona (Verona, Italy) were retrospectively reviewed. Visual acuities, surgeries, PCG subtype and etiology of vision impairment were recorded. Statistical analyses were performed to detect factors associated with vision decline. Results Sixty-seven eyes (40 patients) were included in the study. Developmental predictive curves of visual acuity showed that children with infantile PCG had a better visual outcome than children with neonatal PCG at each step of follow-up. A good-to-moderate VA (p Conclusions Visual outcomes of PCG significantly correlate with the age at diagnosis. Although a good long-term IOP control can often be achieved in PCG, often the visual acuity remains below the lower limits of the normal range. Poor vision in childhood is related to global developmental problems, and referral to third-level services should not be delayed to prevent vision impairment. In this regard, visual acuity curves can be a useful tool for the consultant ophthalmologist to define the visual development of children affected by PCG.
- Published
- 2021
40. Taurine supplementation in conjunction with exercise modulated cytokines and improved subcutaneous white adipose tissue plasticity in obese women
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Márcia Varella Morandi Junqueira-Franco, Julio Sérgio Marchini, Maria Eduarda de Almeida Tavares, Adelino Sanchez Ramos da Silva, José Rodrigo Pauli, Ellen Cristini de Freitas, Vitor Rosetto Muñoz, Giovana Rampazzo Teixeira, Dennys E. Cintra, Flávia Giolo De Carvalho, Gabriela Batitucci, Eduardo R. Ropelle, Leandro Pereira de Moura, Camila Fernanda Cunha Brandao, Universidade de São Paulo (USP), Universidade Estadual de Maringá (UEM), Universidade Estadual de Campinas (UNICAMP), and Universidade Estadual Paulista (UNESP)
- Subjects
medicine.medical_specialty ,Taurine ,Adipocyte plasticity ,Clinical Biochemistry ,Adipose tissue ,Inflammation ,White adipose tissue ,medicine.disease_cause ,Biochemistry ,chemistry.chemical_compound ,Internal medicine ,Adipocyte ,Biopsy ,medicine ,Obesity ,medicine.diagnostic_test ,business.industry ,AMINOÁCIDOS ,Organic Chemistry ,medicine.disease ,Endocrinology ,chemistry ,medicine.symptom ,business ,Oxidative stress - Abstract
Made available in DSpace on 2022-04-29T08:30:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Interventions that can modulate subcutaneous white adipose tissue (scWAT) function, such as exercise training and nutritional components, like taurine, modulate the inflammatory process, therefore, may represent strategies for obesity treatment. We investigated the effects of taurine supplementation in conjunction with exercise on inflammatory and oxidative stress markers in plasma and scWAT of obese women. Sixteen obese women were randomized into two groups: Taurine supplementation group (Tau, n = 8) and Taurine supplementation + exercise group (Tau + Exe, n = 8). The intervention was composed of daily taurine supplementation (3 g) and exercise training for 8 weeks. Anthropometry, body fat composition, and markers of inflammatory and oxidative stress were determined in plasma and scWAT biopsy samples before and after the intervention. We found that, although taurine supplementation increased taurine plasma levels, no changes were observed for the anthropometric characteristics. However, Tau alone decreased interleukin-6 (IL-6), and in conjunction with exercise (Tau + Exe), increased anti-inflammatory interleukins (IL-15 and IL10), followed by reduced IL1β gene expression in the scWAT of obese women. Tau and Tau + Exe groups presented reduced adipocyte size and increased connective tissue and multilocular droplets. In conclusion, taurine supplementation in conjunction with exercise modulated levels of inflammatory markers in plasma and scWAT, and improved scWAT plasticity in obese women, promoting protection against obesity-induced inflammation. TRN NCT04279600 retrospectively registered on August 18, 2019. School of Physical Education and Sport of Ribeirão Preto University of São Paulo-EEFERP USP, Av. Bandeirantes, 3900, Vila Monte Alegre Internal Medicine Department Ribeirão Preto Medical School University of São Paulo-FMRP USP State University of Minas Gerais - UEMG, Divinopolis unit Laboratory of Molecular Biology of Exercise University of Campinas-FCA UNICAMP Department of Food and Nutrition School of Pharmaceutical Sciences of Araraquara São Paulo State University-FCFAR UNESP Department of Physical Education School of Technology and Science São Paulo State University-UNESP Laboratory of Nutritional Genomics University of Campinas-FCA UNICAMP Department of Food and Nutrition School of Pharmaceutical Sciences of Araraquara São Paulo State University-FCFAR UNESP Department of Physical Education School of Technology and Science São Paulo State University-UNESP FAPESP: 2017/08036-5 FAPESP: 2017/10080-2
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- 2021
41. Computationally efficient whole-genome regression for quantitative and binary traits
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Lukas Habegger, Joshua D. Backman, Gonçalo R. Abecasis, Jack A. Kosmicki, Leland Barnard, Jeffrey S. Reid, Boris Boutkov, Andrey Ziyatdinov, Jonathan Marchini, Christian Benner, Evan Maxwell, Anthony Marcketta, Manuel A. R. Ferreira, Joelle Mbatchou, Aris Baras, Mathew Barber, and Colm O'Dushlaine
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Genotype ,Binary number ,Sample (statistics) ,Biology ,computer.software_genre ,Logistic regression ,Machine Learning ,03 medical and health sciences ,0302 clinical medicine ,Software ,Genetics ,Humans ,030304 developmental biology ,0303 health sciences ,business.industry ,Computational Biology ,Reproducibility of Results ,Contrast (statistics) ,Regression analysis ,Genomics ,Regression ,Logistic Models ,Phenotype ,ComputingMethodologies_PATTERNRECOGNITION ,Efficiency ,Case-Control Studies ,Data mining ,business ,computer ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Genome-wide association analysis of cohorts with thousands of phenotypes is computationally expensive, particularly when accounting for sample relatedness or population structure. Here we present a novel machine-learning method called REGENIE for fitting a whole-genome regression model for quantitative and binary phenotypes that is substantially faster than alternatives in multi-trait analyses while maintaining statistical efficiency. The method naturally accommodates parallel analysis of multiple phenotypes and requires only local segments of the genotype matrix to be loaded in memory, in contrast to existing alternatives, which must load genome-wide matrices into memory. This results in substantial savings in compute time and memory usage. We introduce a fast, approximate Firth logistic regression test for unbalanced case–control phenotypes. The method is ideally suited to take advantage of distributed computing frameworks. We demonstrate the accuracy and computational benefits of this approach using the UK Biobank dataset with up to 407,746 individuals. REGENIE is a whole-genome regression method based on ridge regression that enables highly parallelized analysis of quantitative and binary traits in biobank-scale data with reduced computational requirements.
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- 2021
42. Untargeted lipidomic analysis of plasma from obese women submitted to combined physical exercise
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Rocio, San Martin, Camila Fernanda Cunha, Brandao, Márcia Varella Morandi, Junqueira-Franco, Gizela Pedroso, Junqueira, Ellen Cristini, de Freitas, Flavia Giolo, de Carvalho, Caio Henrique Pinke, Rodrigues, Audrey, Aguesse, Stéphanie, Billon-Crossouard, Michel, Krempf, Mikaël, Croyal, and Julio Sergio, Marchini
- Subjects
Adult ,Arachidonic Acid ,Multidisciplinary ,EXERCÍCIO FÍSICO ,Lipidomics ,Humans ,Female ,Obesity ,Waist Circumference ,Exercise ,Body Mass Index - Abstract
This study aimed to determine the changes of lipidome in obese women undergoing combined physical exercise training. Fourteen adult women with obesity (mean BMI and age, 33 kg/m2 and 34 ± 5 years), were submitted to combined physical training (aerobic and strength exercises, alternately, 55 min at 75–90% of the maximum heart rate, 3 times a week) for 8 weeks. All participants were evaluated before and after the training intervention for lipidome, anthropometric measurements, muscle strength, and maximum oxygen consumption (VO2max). Untargeted liquid chromatography-mass spectrometry analyses allowed the identification of 1252 variables, of which 160 were significant (p p
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- 2022
43. Child, adolescent, and parent mental health in general population during a year of COVID-19 pandemic in belgium: a cross-sectional study
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Amélyne Wauters, Julien Tiete, Joana Reis, Isabelle Lambotte, Simone Marchini, and Véronique Delvenne
- Abstract
Background This study aims to evaluate the mental health status of children, adolescents and their parents during the first year of COVID-19 pandemic in Belgium. Method Analysis compared results before and during the second national lockdown, which started on November 2nd 2020. A cross-sectional online survey was conducted between May 2020 and April 2021. Results Two hundred and eighteen adults and 273 children fully completed the survey. Almost one in five children (17.9%) presented moderate-to-severe scores of depression. Adolescents presented a higher level of depression than children (p = 0.007). The rate of moderate-to-severe depression scores (10.8% to 21%, p = 0.007) and internalized symptoms increased during the second lockdown (p Conclusion The second lockdown appears to worsen the effects of the pandemic on children’s and parents’ mental health. There is a need to implement specific interventions targeting both children/adolescents and their parents to support them during lockdown periods and improve mental health outcomes.
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- 2022
44. MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses
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Jay Devine, Marta Vidal-García, Wei Liu, Amanda Neves, Lucas D. Lo Vercio, Rebecca M. Green, Heather A. Richbourg, Marta Marchini, Colton M. Unger, Audrey C. Nickle, Bethany Radford, Nathan M. Young, Paula N. Gonzalez, Robert E. Schuler, Alejandro Bugacov, Campbell Rolian, Christopher J. Percival, Trevor Williams, Lee Niswander, Anne L. Calof, Arthur D. Lander, Axel Visel, Frank R. Jirik, James M. Cheverud, Ophir D. Klein, Ramon Y. Birnbaum, Amy E. Merrill, Rebecca R. Ackermann, Daniel Graf, Myriam Hemberger, Wendy Dean, Nils D. Forkert, Stephen A. Murray, Henrik Westerberg, Ralph S. Marcucio, and Benedikt Hallgrímsson
- Subjects
Pediatric ,Statistics and Probability ,Databases, Factual ,Brain ,X-Ray Microtomography ,Library and Information Sciences ,Computer Science Applications ,Education ,Databases ,Mice ,Genetics ,Animals ,Statistics, Probability and Uncertainty ,Factual ,Information Systems - Abstract
Complex morphological traits are the product of many genes with transient or lasting developmental effects that interact in anatomical context. Mouse models are a key resource for disentangling such effects, because they offer myriad tools for manipulating the genome in a controlled environment. Unfortunately, phenotypic data are often obtained using laboratory-specific protocols, resulting in self-contained datasets that are difficult to relate to one another for larger scale analyses. To enable meta-analyses of morphological variation, particularly in the craniofacial complex and brain, we created MusMorph, a database of standardized mouse morphology data spanning numerous genotypes and developmental stages, including E10.5, E11.5, E14.5, E15.5, E18.5, and adulthood. To standardize data collection, we implemented an atlas-based phenotyping pipeline that combines techniques from image registration, deep learning, and morphometrics. Alongside stage-specific atlases, we provide aligned micro-computed tomography images, dense anatomical landmarks, and segmentations (if available) for each specimen (N = 10,056). Our workflow is open-source to encourage transparency and reproducible data collection. The MusMorph data and scripts are available on FaceBase (www.facebase.org, https://doi.org/10.25550/3-HXMC) and GitHub (https://github.com/jaydevine/MusMorph).
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- 2022
45. Femtosecond laser-assisted implantation of corneal stroma lenticule for keratoconus
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Alice Galzignato, Emilio Pedrotti, Tiziano Cozzini, Adriano Fasolo, Chiara Chierego, Erika Bonacci, and Giorgio Marchini
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0301 basic medicine ,Keratoconus ,medicine.medical_specialty ,genetic structures ,Corneal Surgery, Laser ,Corneal Stroma ,Review ,Corneal Transplantation ,Corneal stroma lenticule implantation ,03 medical and health sciences ,0302 clinical medicine ,Stroma ,Cornea ,Ophthalmology ,medicine ,Humans ,In patient ,Stromal keratophakia ,Normal range ,Keratophakia ,Additive keratoplasty ,Intrastromal inlay ,business.industry ,Lasers ,Corneal Topography ,medicine.disease ,Laser assisted ,eye diseases ,Femtosecond laser ,030104 developmental biology ,medicine.anatomical_structure ,Femtosecond ,030221 ophthalmology & optometry ,sense organs ,business - Abstract
Purpose To review recent progress, challenges, and future perspectives of stromal keratophakia for the treatment of advanced keratoconus. Methods We systematically reviewed the literature in the PubMed database, last update June 30, 2020. No language restriction was applied. The authors checked the reference lists of the retrieved articles to identify any additional study of interest. Results Several techniques have been proposed for the treatment of keratoconus in order to avoid or delay keratoplasty. This was primarily due to the lack of accessibility to donor corneas in many countries. The ease and predictability of the more advanced femtosecond lasers used to correct ametropias by stromal lenticule extraction lead to hypothesize that generated refractive lenticules could be implanted into corneal stromal layers to restore volume and alter the refractive properties of the cornea in patients with corneal ectasias. At the same time, new techniques for preservation, customization, and cellular therapy of the corneal stromal have been developed, directing to the valorization of otherwise discarded byproducts such as donor corneas unsuitable for either lamellar of penetrating keratoplasty. Conclusions Femtosecond laser-assisted stromal keratophakia could be a suitable therapeutic option for the treatment of corneal ectasias, especially in patients with advanced keratoconus, providing biomechanical support recovering the pachimetry to nearly normal value at the same time. The accuracy and predictability of the refractive outcome are yet a critical issue and the patient eligible for the procedure still has to be characterized.
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- 2021
46. Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
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Mannarino, Laura, primary, Mirimao, Federica, additional, Panini, Nicolò, additional, Paracchini, Lara, additional, Marchini, Sergio, additional, Beltrame, Luca, additional, Amodeo, Rosy, additional, Grosso, Federica, additional, Libener, Roberta, additional, De Simone, Irene, additional, Ceresoli, Giovanni L., additional, Zucali, Paolo A., additional, Lupi, Monica, additional, and D’Incalci, Maurizio, additional
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- 2022
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47. Early and late onset sepsis and retinopathy of prematurity in a cohort of preterm infants
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Bonafiglia, Elena, primary, Gusson, Elena, additional, Longo, Rosa, additional, Ficial, Benjamim, additional, Tisato, Maria Giulia, additional, Rossignoli, Sara, additional, Caltran, Giulia, additional, Pedrotti, Emilio, additional, Beghini, Renzo, additional, and Marchini, Giorgio, additional
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- 2022
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48. Expert Consensus on the Use of the PRESERFLO™ MicroShunt Device in the Treatment of Glaucoma: A Modified Delphi Panel
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Khawaja, Anthony P., primary, Stalmans, Ingeborg, additional, Aptel, Florent, additional, Barton, Keith, additional, Beckers, Henny, additional, Klink, Thomas, additional, Marchini, Giorgio, additional, Martínez de la Casa, Jose, additional, Simonsen, Jan H., additional, Töteberg-Harms, Marc, additional, Vass, Clemens, additional, and Abegão Pinto, Luís, additional
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- 2022
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49. Untargeted lipidomic analysis of plasma from obese women submitted to combined physical exercise
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San Martin, Rocio, primary, Brandao, Camila Fernanda Cunha, additional, Junqueira-Franco, Márcia Varella Morandi, additional, Junqueira, Gizela Pedroso, additional, de Freitas, Ellen Cristini, additional, de Carvalho, Flavia Giolo, additional, Rodrigues, Caio Henrique Pinke, additional, Aguesse, Audrey, additional, Billon-Crossouard, Stéphanie, additional, Krempf, Michel, additional, Croyal, Mikaël, additional, and Marchini, Julio Sergio, additional
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- 2022
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50. Child, adolescent, and parent mental health in general population during a year of COVID-19 pandemic in belgium: a cross-sectional study
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Wauters, Amélyne, primary, Tiete, Julien, additional, Reis, Joana, additional, Lambotte, Isabelle, additional, Marchini, Simone, additional, and Delvenne, Véronique, additional
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- 2022
- Full Text
- View/download PDF
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