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49 results on '"Malumbres, Marcos"'

1. miR-203 drives breast cancer cell differentiation

Author

Martínez-Illescas, Nuria G., primary, Leal, Silvia, additional, González, Patricia, additional, Graña-Castro, Osvaldo, additional, Muñoz-Oliveira, Juan José, additional, Cortés-Peña, Alfonso, additional, Gómez-Gil, María, additional, Vega, Zaira, additional, Neva, Verónica, additional, Romero, Andrea, additional, Quintela-Fandino, Miguel, additional, Ciruelos, Eva, additional, Sanz, Consuelo, additional, Aragón, Sofía, additional, Sotolongo, Leisy, additional, Jiménez, Sara, additional, Caleiras, Eduardo, additional, Mulero, Francisca, additional, Sánchez, Cristina, additional, Malumbres, Marcos, additional, and Salazar-Roa, María, additional

Published
2023
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2. Correction to: CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation

Author

Frontiñán-Rubio, Javier, primary, Llanos-González, Emilio, additional, García-Carpintero, Sonia, additional, Peinado, Juan Ramón, additional, Ballesteros-Yáñez, Inmaculada, additional, Rayo, Margarita Villar, additional, de la Fuente, José, additional, Pérez-García, Víctor M., additional, Perez-Romasanta, Luis A., additional, Malumbres, Marcos, additional, Alcaín, Francisco J., additional, and Durán-Prado, Mario, additional

Published
2023
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3. Decoding protein methylation function with thermal stability analysis

Author

Sayago, Cristina, primary, Sánchez-Wandelmer, Jana, additional, García, Fernando, additional, Hurtado, Begoña, additional, Lafarga, Vanesa, additional, Prieto, Patricia, additional, Zarzuela, Eduardo, additional, Ximénez-Embún, Pilar, additional, Ortega, Sagrario, additional, Megías, Diego, additional, Fernández-Capetillo, Oscar, additional, Malumbres, Marcos, additional, and Munoz, Javier, additional

Published
2023
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4. Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells

Author

Villarroya‐Beltri, Carolina, primary, Martins, Ana Filipa B, additional, García, Alejandro, additional, Giménez, Daniel, additional, Zarzuela, Eduardo, additional, Novo, Mónica, additional, del Álamo, Cristina, additional, González‐Martínez, José, additional, Bonel‐Pérez, Gloria C, additional, Díaz, Irene, additional, Guillamot, María, additional, Chiesa, Massimo, additional, Losada, Ana, additional, Graña‐Castro, Osvaldo, additional, Rovira, Meritxell, additional, Muñoz, Javier, additional, Salazar‐Roa, María, additional, and Malumbres, Marcos, additional

Published
2022
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5. CoQ10 reduces glioblastoma growth and infiltration through proteome remodeling and inhibition of angiogenesis and inflammation

Author

Frontiñán-Rubio, Javier, primary, Llanos-González, Emilio, additional, García-Carpintero, Sonia, additional, Peinado, Juan Ramón, additional, Ballesteros-Yáñez, Inmaculada, additional, Rayo, Margarita Villar, additional, de la Fuente, José, additional, Pérez-García, Víctor M., additional, Perez-Romasanta, Luis A., additional, Malumbres, Marcos, additional, Alcaín, Francisco J., additional, and Durán-Prado, Mario, additional

Published
2022
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6. Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division

Author

González-Martínez, José, primary, Cwetsch, Andrzej W., additional, Gilabert-Juan, Javier, additional, Gómez, Jesús, additional, Garaulet, Guillermo, additional, Schneider, Paulina, additional, de Cárcer, Guillermo, additional, Mulero, Francisca, additional, Caleiras, Eduardo, additional, Megías, Diego, additional, Porlan, Eva, additional, and Malumbres, Marcos, additional

Published
2022
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9. p38γ is essential for cell cycle progression and liver tumorigenesis

Author

Tomás-Loba, Antonia, primary, Manieri, Elisa, additional, González-Terán, Bárbara, additional, Mora, Alfonso, additional, Leiva-Vega, Luis, additional, Santamans, Ayelén M., additional, Romero-Becerra, Rafael, additional, Rodríguez, Elena, additional, Pintor-Chocano, Aránzazu, additional, Feixas, Ferran, additional, López, Juan Antonio, additional, Caballero, Beatriz, additional, Trakala, Marianna, additional, Blanco, Óscar, additional, Torres, Jorge L., additional, Hernández-Cosido, Lourdes, additional, Montalvo-Romeral, Valle, additional, Matesanz, Nuria, additional, Roche-Molina, Marta, additional, Bernal, Juan Antonio, additional, Mischo, Hannah, additional, León, Marta, additional, Caballero, Ainoa, additional, Miranda-Saavedra, Diego, additional, Ruiz-Cabello, Jesús, additional, Nevzorova, Yulia A., additional, Cubero, Francisco Javier, additional, Bravo, Jerónimo, additional, Vázquez, Jesús, additional, Malumbres, Marcos, additional, Marcos, Miguel, additional, Osuna, Sílvia, additional, and Sabio, Guadalupe, additional

Published
2019
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10. Detection of novel fusion-transcripts by RNA-Seq in T-cell lymphoblastic lymphoma

Author

López-Nieva, Pilar, primary, Fernández-Navarro, Pablo, additional, Graña-Castro, Osvaldo, additional, Andrés-León, Eduardo, additional, Santos, Javier, additional, Villa-Morales, María, additional, Cobos-Fernández, María Ángeles, additional, González-Sánchez, Laura, additional, Malumbres, Marcos, additional, Salazar-Roa, María, additional, and Fernández-Piqueras, José, additional

Published
2019
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12. Downregulation of specific FBXW7 isoforms with differential effects in T-cell lymphoblastic lymphoma

Author

Vázquez-Domínguez, Irene, primary, González-Sánchez, Laura, additional, López-Nieva, Pilar, additional, Fernández-Navarro, Pablo, additional, Villa-Morales, María, additional, Cobos-Fernández, María Á., additional, Sastre, Isabel, additional, F. Fraga, Mario, additional, F. Fernández, Agustín, additional, Malumbres, Marcos, additional, Salazar-Roa, María, additional, Graña-Castro, Osvaldo, additional, Santos, Javier, additional, Llamas, Pilar, additional, López-Lorenzo, José L., additional, and Fernández-Piqueras, José, additional

Published
2019
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14. Plk1 overexpression induces chromosomal instability and suppresses tumor development

Author

de Cárcer, Guillermo, primary, Venkateswaran, Sharavan Vishaan, additional, Salgueiro, Lorena, additional, El Bakkali, Aicha, additional, Somogyi, Kalman, additional, Rowald, Konstantina, additional, Montañés, Pablo, additional, Sanclemente, Manuel, additional, Escobar, Beatriz, additional, de Martino, Alba, additional, McGranahan, Nicholas, additional, Malumbres, Marcos, additional, and Sotillo, Rocío, additional

Published
2018
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15. RNA-Seq reveals the existence of a CDKN1C-E2F1-TP53 axis that is altered in human T-cell lymphoblastic lymphomas

Author

López-Nieva, Pilar, primary, Fernández-Navarro, Pablo, additional, Vaquero-Lorenzo, Concepción, additional, Villa-Morales, María, additional, Graña-Castro, Osvaldo, additional, Cobos-Fernández, María Ángeles, additional, López-Lorenzo, José Luis, additional, Llamas, Pilar, additional, González-Sanchez, Laura, additional, Sastre, Isabel, additional, Pollan, Marina, additional, Malumbres, Marcos, additional, Santos, Javier, additional, and Fernández-Piqueras, José, additional

Published
2018
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16. Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer

Author

Álvarez-Fernández, Mónica, primary, Sanz-Flores, María, additional, Sanz-Castillo, Belén, additional, Salazar-Roa, María, additional, Partida, David, additional, Zapatero-Solana, Elisabet, additional, Ali, H. Raza, additional, Manchado, Eusebio, additional, Lowe, Scott, additional, VanArsdale, Todd, additional, Shields, David, additional, Caldas, Carlos, additional, Quintela-Fandino, Miguel, additional, and Malumbres, Marcos, additional

Published
2017
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17. Erratum: The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

Author

Ha, Kyungsoo, primary, Ma, Chengxian, additional, Lin, Han, additional, Tang, Lichun, additional, Lian, Zhusheng, additional, Zhao, Fang, additional, Li, Ju-Mei, additional, Zhen, Bei, additional, Pei, Huadong, additional, Han, Suxia, additional, Malumbres, Marcos, additional, Jin, Jianping, additional, Chen, Huan, additional, Zhao, Yongxiang, additional, Zhu, Qing, additional, and Zhang, Pumin, additional

Published
2017
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18. Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

Author

de Cárcer, Guillermo, primary, Wachowicz, Paulina, additional, Martínez-Martínez, Sara, additional, Oller, Jorge, additional, Méndez-Barbero, Nerea, additional, Escobar, Beatriz, additional, González-Loyola, Alejandra, additional, Takaki, Tohru, additional, El Bakkali, Aicha, additional, Cámara, Juan A, additional, Jiménez-Borreguero, Luis J, additional, Bustelo, Xosé R, additional, Cañamero, Marta, additional, Mulero, Francisca, additional, de los Ángeles Sevilla, María, additional, Montero, María Jose, additional, Redondo, Juan Miguel, additional, and Malumbres, Marcos, additional

Published
2017
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19. The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

Author

Ha, Kyungsoo, primary, Ma, Chengxian, additional, Lin, Han, additional, Tang, Lichun, additional, Lian, Zhusheng, additional, Zhao, Fang, additional, Li, Ju-Mei, additional, Zhen, Bei, additional, Pei, Huadong, additional, Han, Suxia, additional, Malumbres, Marcos, additional, Jin, Jianping, additional, Chen, Huan, additional, Zhao, Yongxiang, additional, Zhu, Qing, additional, and Zhang, Pumin, additional

Published
2017
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21. Aurora A drives early signalling and vesicle dynamics during T-cell activation

Author

Blas-Rus, Noelia, primary, Bustos-Morán, Eugenio, additional, Pérez de Castro, Ignacio, additional, de Cárcer, Guillermo, additional, Borroto, Aldo, additional, Camafeita, Emilio, additional, Jorge, Inmaculada, additional, Vázquez, Jesús, additional, Alarcón, Balbino, additional, Malumbres, Marcos, additional, Martín-Cófreces, Noa B., additional, and Sánchez-Madrid, Francisco, additional

Published
2016
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24. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

Author

Doménech, Elena, primary, Maestre, Carolina, additional, Esteban-Martínez, Lorena, additional, Partida, David, additional, Pascual, Rosa, additional, Fernández-Miranda, Gonzalo, additional, Seco, Esther, additional, Campos-Olivas, Ramón, additional, Pérez, Manuel, additional, Megias, Diego, additional, Allen, Katherine, additional, López, Miguel, additional, Saha, Asish K., additional, Velasco, Guillermo, additional, Rial, Eduardo, additional, Méndez, Raúl, additional, Boya, Patricia, additional, Salazar-Roa, María, additional, and Malumbres, Marcos, additional

Published
2015
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25. PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

Author

Serra, Helena, primary, Chivite, Iñigo, additional, Angulo-Urarte, Ana, additional, Soler, Adriana, additional, Sutherland, James D., additional, Arruabarrena-Aristorena, Amaia, additional, Ragab, Anan, additional, Lim, Radiance, additional, Malumbres, Marcos, additional, Fruttiger, Marcus, additional, Potente, Michael, additional, Serrano, Manuel, additional, Fabra, Àngels, additional, Viñals, Francesc, additional, Casanovas, Oriol, additional, Pandolfi, Pier Paolo, additional, Bigas, Anna, additional, Carracedo, Arkaitz, additional, Gerhardt, Holger, additional, and Graupera, Mariona, additional

Published
2015
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27. Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia

Author

Piazzolla, Daniela, primary, Palla, Adelaida R., additional, Pantoja, Cristina, additional, Cañamero, Marta, additional, de Castro, Ignacio Perez, additional, Ortega, Sagrario, additional, Gómez-López, Gonzalo, additional, Dominguez, Orlando, additional, Megías, Diego, additional, Roncador, Giovanna, additional, Luque-Garcia, Jose L., additional, Fernandez-Tresguerres, Beatriz, additional, Fernandez, Agustin F., additional, Fraga, Mario F., additional, Rodriguez-Justo, Manuel, additional, Manzanares, Miguel, additional, Sánchez-Carbayo, Marta, additional, García-Pedrero, Juana María, additional, Rodrigo, Juan P., additional, Malumbres, Marcos, additional, and Serrano, Manuel, additional

Published
2014
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31. Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells

Author

Parrillas, Verónica, primary, Martínez-Muñoz, Laura, additional, Holgado, Borja L., additional, Kumar, Amit, additional, Cascio, Graciela, additional, Lucas, Pilar, additional, Rodríguez-Frade, José Miguel, additional, Malumbres, Marcos, additional, Carrera, Ana C., additional, van Wely, Karel HM, additional, and Mellado, Mario, additional

Published
2012
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33. Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin

Author

Muñoz, Inés G, primary, Yébenes, Hugo, additional, Zhou, Min, additional, Mesa, Pablo, additional, Serna, Marina, additional, Park, Ah Young, additional, Bragado-Nilsson, Elisabeth, additional, Beloso, Ana, additional, de Cárcer, Guillermo, additional, Malumbres, Marcos, additional, Robinson, Carol V, additional, Valpuesta, José M, additional, and Montoya, Guillermo, additional

Published
2010
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34. Cyclin-dependent kinases: a family portrait

Author

Malumbres, Marcos, primary, Harlow, Edward, additional, Hunt, Tim, additional, Hunter, Tony, additional, Lahti, Jill M., additional, Manning, Gerard, additional, Morgan, David O., additional, Tsai, Li-Huei, additional, and Wolgemuth, Debra J., additional

Published
2009
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37. Cdk1 is sufficient to drive the mammalian cell cycle

Author

Santamaría, David, primary, Barrière, Cédric, additional, Cerqueira, Antonio, additional, Hunt, Sarah, additional, Tardy, Claudine, additional, Newton, Kathryn, additional, Cáceres, Javier F., additional, Dubus, Pierre, additional, Malumbres, Marcos, additional, and Barbacid, Mariano, additional

Published
2007
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49. Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer

Author

Eusebio Manchado, David Shields, María Sanz-Flores, David Partida, Marcos Malumbres, H. Raza Ali, Todd VanArsdale, Elisabet Zapatero-Solana, Miguel Quintela-Fandino, Mónica Álvarez-Fernández, Belén Sanz-Castillo, Scott W. Lowe, María Salazar-Roa, Carlos Caldas, Malumbres, Marcos [0000-0002-0829-6315], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Mice, Nude, Breast Neoplasms, Biology, Protein Serine-Threonine Kinases, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, Mice, Breast cancer, RNA interference, Cell Line, Tumor, medicine, Animals, Humans, Protein Phosphatase 2, Kinase activity, Molecular Biology, Mitosis, Kinase, Cancer, Cell Biology, Cell cycle, medicine.disease, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, 030104 developmental biology, Mitotic exit, Gene Knockdown Techniques, Cancer research, Female, Microtubule-Associated Proteins
Abstract

PP2A is a major tumor suppressor whose inactivation is frequently found in a wide spectrum of human tumors. In particular, deletion or epigenetic silencing of genes encoding the B55 family of PP2A regulatory subunits is a common feature of breast cancer cells. A key player in the regulation of PP2A/B55 phosphatase complexes is the cell cycle kinase MASTL (also known as Greatwall). During cell division, inhibition of PP2A-B55 by MASTL is required to maintain the mitotic state, whereas inactivation of MASTL and PP2A reactivation is required for mitotic exit. Despite its critical role in cell cycle progression in multiple organisms, its relevance as a therapeutic target in human cancer and its dependence of PP2A activity is mostly unknown. Here we show that MASTL overexpression predicts poor survival and shows prognostic value in breast cancer patients. MASTL knockdown or knockout using RNA interference or CRISPR/Cas9 systems impairs proliferation of a subset of breast cancer cells. The proliferative function of MASTL in these tumor cells requires its kinase activity and the presence of PP2A-B55 complexes. By using a new inducible CRISPR/Cas9 system in breast cancer cells, we show that genetic ablation of MASTL displays a significant therapeutic effect in vivo. All together, these data suggest that the PP2A inhibitory kinase MASTL may have both prognostic and therapeutic value in human breast cancer.

Published
2018

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