1. Chemical constituents from Sanguisorba officinalis L. and their inhibitory effects on LPS-stimulated pro-inflammatory cytokine production in bone marrow-derived dendritic cells
- Author
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Seo Young Yang, Young Ho Kim, Irshad Ali, Xiang Dong Su, Young Sang Koh, and Madeeha Arooj
- Subjects
Lipopolysaccharides ,0301 basic medicine ,Astringent ,medicine.drug_class ,medicine.medical_treatment ,Anti-Inflammatory Agents ,Plant Roots ,01 natural sciences ,Sanguisorba ,Anti-inflammatory ,Mice ,Structure-Activity Relationship ,03 medical and health sciences ,Bone Marrow ,Sanguisorba officinalis ,Drug Discovery ,medicine ,Animals ,Cells, Cultured ,Dose-Response Relationship, Drug ,Molecular Structure ,Traditional medicine ,biology ,Plant Extracts ,Chemistry ,Organic Chemistry ,Dendritic Cells ,Dendritic cell ,biology.organism_classification ,Terpenoid ,0104 chemical sciences ,Mice, Inbred C57BL ,010404 medicinal & biomolecular chemistry ,030104 developmental biology ,Cytokine ,Phytochemical ,Officinalis ,Cytokines ,Molecular Medicine - Abstract
Sanguisorba officinalis L. (Rosaceae) is a perennial herbaceous plant and its roots have been used as an important astringent medicine in Eastern Asian countries over many thousand years. In this phytochemical research, 23 compounds (1-23) were isolated from the roots of S. officinalis. Their chemical structures were identified by extensive spectroscopic methods, including 1D and 2D NMR experiments. The anti-inflammatory effects of extracts and isolated compounds were investigated by measuring the production of pro-inflammatory cytokine IL-12 p40, IL-6 and TNF-α in LPS-stimulated bone marrow-derived dendritic cell. Compounds 1, 3, 7-8, 11-14 revealed promising anti-inflammatory effects. These results suggested that some phenolic compounds and monoterpenoids from S. officinalis could be potential candidates for anti-inflammatory treatments.
- Published
- 2018
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