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14 results on '"Macera, Margherita"'

1. Effectiveness of test-and-treat model with direct-acting antiviral for hepatitis C virus infection in migrants: a prospective interventional study in Italy

Author

Coppola, Nicola, primary, Alessio, Loredana, additional, De Pascalis, Stefania, additional, Macera, Margherita, additional, Di Caprio, Giovanni, additional, Messina, Vincenzo, additional, Onorato, Lorenzo, additional, Minichini, Carmine, additional, Stanzione, Maria, additional, Stornaiuolo, Gianfranca, additional, Starace, Mario, additional, Monari, Caterina, additional, Calò, Federica, additional, Sagnelli, Caterina, additional, and Pisaturo, Mariantonietta, additional

Published
2024
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2. The impact of a non-restrictive Antimicrobial Stewardship Program in the emergency department of a secondary-level Italian hospital

Author

Monari, Caterina, primary, Onorato, Lorenzo, additional, Allegorico, Enrico, additional, Minerva, Valentina, additional, Macera, Margherita, additional, Bosso, Giorgio, additional, Calò, Federica, additional, Pagano, Antonio, additional, Russo, Teresa, additional, Sansone, Gennaro, additional, D’Isanto, Marina, additional, Casciotta, Antonio, additional, Vanni, Monica, additional, Numis, Fabio Giuliano, additional, and Coppola, Nicola, additional

Published
2023
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3. Correction: Hepatitis D virus infection in a large cohort of immigrants in southern Italy: a multicenter, prospective study

Author

Pisaturo, Mariantonietta, primary, Alessio, Loredana, additional, Di Fraia, Alessandra, additional, Macera, Margherita, additional, Minichini, Carmine, additional, Cordua, Emanuele, additional, Onorato, Lorenzo, additional, Scotto, Gaetano, additional, Di Caprio, Giovanni, additional, Calò, Federica, additional, Sagnelli, Caterina, additional, and Coppola, Nicola, additional

Published
2023
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4. Epidemiological and etiological variations in hepatocellular carcinoma

Author

Sagnelli, Evangelista, Macera, Margherita, Russo, Antonio, Coppola, Nicola, Sagnelli, Caterina, RUSSO, ANTONIO, Sagnelli, Evangelista, Macera, Margherita, Russo, Antonio, Coppola, Nicola, and Sagnelli, Caterina

Subjects
0301 basic medicine, Microbiology (medical), Oncology, Alcoholic liver disease, medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, Epidemiology, Hepatocellular carcinoma, 030106 microbiology, medicine.disease_cause, Chronic liver disease, 03 medical and health sciences, 0302 clinical medicine, NAFLD, Internal medicine, Prevalence, medicine, Humans, 030212 general & internal medicine, Hepatitis B virus, business.industry, Incidence, Liver Neoplasms, Fatty liver, NASH, Hepatitis B viru, General Medicine, medicine.disease, digestive system diseases, Infectious Diseases, Steatohepatitis, Alcohol, Hepatitis C viru, business, Liver cancer
Abstract

Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer and a leading cause of cancer-related deaths worldwide. The major risk factors for HCC development are chronic liver disease and cirrhosis due to hepatitis B virus (HBV) and/or hepatitis C virus (HCV), alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), steatohepatitis, intake of aflatoxin-contaminated food, diabetes, and obesity. In Western countries, the number of NASH-related HCC cases is increasing, that of HBV- or HCV-related cases is declining due to the wide application of HBV universal vaccination and the introduction of effective therapies against HBV and HCV infections, and that of alcohol-related cases remaining substantially unchanged. Nevertheless, the burden of HCC is expected to increase worldwide in the next few decades, due to the population growth and aging expected in coming years. Overall, the abovementioned changes and future variations in lifestyle and in the impact of environmental factors in Western countries and a decreasing exposure to dietary aflatoxins and improved socio-economic conditions in developing countries will create new HCC epidemiology in the next few decades. A substantial further reduction in cases of HCC requires a wider application of universal HBV vaccination and effective treatment of HBV- and HCV-related chronic hepatitis and cirrhosis, more effective campaigns to favor correct dietary habits and reduce alcohol consumption and the intensification of studies on HCC pathogenesis for future optimized prevention strategies.

Published
2019

6. Anticoagulant treatment in COVID-19: a narrative review

Author

Carfora, Vincenzo, Spiniello, Giorgio, Ricciolino, Riccardo, Di Mauro, Marco, Migliaccio, Marco Giuseppe, Mottola, Filiberto Fausto, Verde, Nicoletta, Coppola, Nicola, Sagnelli, Caterina, De Pascalis, Stefania, Stanzione, Maria, Stornaiuolo, Gianfranca, Cascone, Angela, Martini, Salvatore, Macera, Margherita, Monari, Caterina, Calò, Federica, Bianco, Andrea, Russo, Antonio, Gentile, Valeria, Camaioni, Clarissa, De Angelis, Giulia, Marino, Giulia, Astorri, Roberta, De Sio, Ilario, Niosi, Marco, Borrelli, Serena, Celia, Benito, Ceparano, Maria, Cirillo, Salvatore, De Luca, Maria, Mazzeo, Grazia, Paoli, Giorgio, Russo, Maria Giovanna, Carfora, V., Spiniello, G., Ricciolino, R., Di Mauro, M., Migliaccio, M. G., Mottola, F. F., Verde, N., Coppola, N., Sagnelli, C., De Pascalis, S., Stanzione, M., Stornaiuolo, G., Cascone, A., Martini, S., Macera, M., Monari, C., Calo, F., Bianco, A., Gentile, V., Camaioni, C., De Angelis, G., Marino, G., Astorri, R., De Sio, I., Niosi, M., Borrelli, S., Celia, B., Ceparano, M., Cirillo, S., De Luca, M., Mazzeo, G., Paoli, G., Russo, M. G., and Russo, A.

Subjects
medicine.medical_specialty, Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, Article, Pathogenesis, 03 medical and health sciences, Anticoagulation, 0302 clinical medicine, Internal medicine, Pandemic, medicine, Humans, Thrombophilia, Endothelial dysfunction, Intensive care medicine, 030304 developmental biology, Coronavirus, 0303 health sciences, Hematology, business.industry, SARS-CoV-2, Anticoagulants, COVID-19, Thrombosis, medicine.disease, COVID-19 Drug Treatment, Host-Pathogen Interactions, business, Cytokine storm, Cardiology and Cardiovascular Medicine, Algorithms
Abstract

The actual Coronavirus Disease (COVID 19) pandemic is due to Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a member of the coronavirus family. Besides the respiratory involvement, COVID 19 patients frequently develop a pro-coagulative state caused by virus-induced endothelial dysfunction, cytokine storm and complement cascade hyperactivation. It is common to observe diffuse microvascular thrombi in multiple organs, mostly in pulmonary microvessels. Thrombotic risk seems to be directly related to disease severity and worsens patients’ prognosis. Therefore, the correct understanding of the mechanisms underlying COVID-19 induced prothrombotic state can lead to a thorough assessment of the possible management strategies. Hence, we review the pathogenesis and therapy of COVID 19-related thrombosis disease, focusing on the available evidence on the possible treatment strategies and proposing an algorithm for the anticoagulation strategy based on disease severity.

Published
2020
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7. Correction to: HBV molecular epidemiology and clinical condition of immigrants living in Italy

Author

Sagnelli, Caterina, primary, Ciccozzi, Massimo, additional, Alessio, Loredana, additional, Cella, Eleonora, additional, Gualdieri, Luciano, additional, Pisaturo, Mariantonietta, additional, Minichini, Carmine, additional, Di Caprio, Giovanni, additional, Starace, Mario, additional, Onorato, Lorenzo, additional, Caroprese, Mara, additional, Occhiello, Laura, additional, Angeletti, Silvia, additional, Scotto, Gaetano, additional, Macera, Margherita, additional, Sagnelli, Evangelista, additional, and Coppola, Nicola, additional

Published
2019
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9. Treatment with direct-acting antivirals improves the clinical outcome in patients with HCV-related decompensated cirrhosis: results from an Italian real-life cohort (Liver Network Activity—LINA cohort)

Author

Gentile, Ivan, primary, Scotto, Riccardo, additional, Coppola, Carmine, additional, Staiano, Laura, additional, Amoruso, Daniela Caterina, additional, De Simone, Teresa, additional, Portunato, Federica, additional, De Pascalis, Stefania, additional, Martini, Salvatore, additional, Macera, Margherita, additional, Viceconte, Giulio, additional, Tosone, Grazia, additional, Buonomo, Antonio Riccardo, additional, Borgia, Guglielmo, additional, and Coppola, Nicola, additional

Published
2018
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11. HBV molecular epidemiology and clinical condition of immigrants living in Italy

Author

Sagnelli, Caterina, primary, Ciccozzi, Massimo, additional, Alessio, Loredana, additional, Cella, Eleonora, additional, Gualdieri, Luciano, additional, Pisaturo, Mariantonietta, additional, Minichini, Carmine, additional, Di Caprio, Giovanni, additional, Starace, Mario, additional, Onorato, Lorenzo, additional, Capoprese, Mara, additional, Occhiello, Laura, additional, Angeletti, Silvia, additional, Scotto, Gaetano, additional, Macera, Margherita, additional, Sagnelli, Evangelista, additional, and Coppola, Nicola, additional

Published
2018
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12. Hepatitis B virus infection in undocumented immigrants and refugees in Southern Italy: demographic, virological, and clinical features

Author

Coppola, Nicola, primary, Alessio, Loredana, additional, Gualdieri, Luciano, additional, Pisaturo, Mariantonietta, additional, Sagnelli, Caterina, additional, Minichini, Carmine, additional, Di Caprio, Giovanni, additional, Starace, Mario, additional, Onorato, Lorenzo, additional, Signoriello, Giuseppe, additional, Macera, Margherita, additional, Angelillo, Italo Francesco, additional, Pasquale, Giuseppe, additional, and Sagnelli, Evangelista, additional

Published
2017
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13. Patatin-Like Phospholipase Domain-Containing 3 I148M Variant Is Associated with Liver Steatosis and Fat Distribution in Chronic Hepatitis B

Author

Zampino, Rosa, primary, Coppola, Nicola, additional, Cirillo, Grazia, additional, Boemio, Adriana, additional, Grandone, Anna, additional, Stanzione, Maria, additional, Capoluongo, Nicolina, additional, Marrone, Aldo, additional, Macera, Margherita, additional, Sagnelli, Evangelista, additional, Adinolfi, Luigi Elio, additional, and del Giudice, Emanuele Miraglia, additional

Published
2015
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14. SARS-CoV-2 infection: a hurricane that does not ignore chronic hepatitis

Author

Caterina Sagnelli, Margherita Macera, Clarissa Camaioni, Annabella Salvati, Nicola Coppola, Evangelista Sagnelli, Sagnelli, Caterina, Macera, Margherita, Camaioni, Clarissa, Salvati, Annabella, Coppola, Nicola, and Sagnelli, Evangelista

Subjects
Microbiology (medical), Pandemic, Cyclonic Storms, SARS-CoV-2, COVID-19, General Medicine, Cyclonic Storm, Viral hepatiti, HCV infection, Hepatitis B, Chronic, Infectious Diseases, Humans, Pandemics, HBV infection, Human
Abstract

Background The COVID-19 pandemic significantly compromised screening, laboratory controls, clinical surveillance and treatment of chronic hepatitis patients and worsened their outcome, as evidenced by its significant correlation with advanced cirrhosis, liver decompensation and mortality. Results This pandemic significantly impaired also the sector of liver transplantation, whose wards, operating rooms, outpatients' facilities, and healthcare personnel have been dedicated to patients with COVID-19. In addition, screening and treatment for HBV infection have been delayed or suspended in in most countries, with an increased risk of viral reactivation. Similar delay or suspension have also occurred for universal hepatitis B vaccination programs in many countries. Likewise, COVID-19 pandemic has made unreachable the goal of elimination of HCV infection as a worldwide public-health issue predicted for 2030 by the WHO. Conclusion This review article demonstrates how COVID-19 pandemic is causing serious damage to the sector of liver disease, which has quickly lost the beneficial effects of years of study, research, and clinical and technological application, as well as considerable financial investments.

Published
2022

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