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On the basis of systematic analysis on the motivation and mechanism of displacement and destabilization of the water-induced landslides, this paper completes a study on the relationship between groundwater dynamic effect laws and displacement response characteristics in the process of the colluvial landslide stability evolution. It is found that the displacement and destabilization of landslide are directly controlled by the underground water level variation and also there exists one-to-one corresponding relation between the deformation of landslide and the groundwater level variation. On the basis of the results above, the underground water level increment and the corresponding deformation variation are taken to be as the dynamic load parameter of landslide and the dynamic incremental displacement response parameter, respectively. Then the displacement dynamic appraisal parameter and prediction model of the groundwater dynamic incremental displacement response ratio are determined in term of the basic principle of elastic–plastic mechanics in this paper. Meanwhile, taking the typical colluvial landslide in the Three Gorges Reservoir Area—Xintan landslide as an example, the values and changing rule of the groundwater dynamic incremental displacement response ratio parameter of the A3 and B3 monitoring points on this landslide are obtained by means of the groundwater dynamic incremental displacement response ratio prediction model, finding that the change rule of the dynamic incremental displacement response ratio-time curve is consistent basically with the dynamic stability evolutional law of the actual slope. The research results show that the groundwater dynamic incremental displacement response ratio prediction model can be used to forecast the kinetics of displacement for this slope, and this method has widely theory and extensive practicality.

Antitumor effects of erythromycin and the related mechanism were investigated in the present study. Neuroblastoma cells (SH-SY5Y) were exposed to erythromycin at different concentrations for different durations. Cell proliferation was measured by cell counting, and cell viability was examined by MTT assay. Cell cycle phase distribution and the cytosolic calcium level were detected by flow cytometry. Mitochondrial membrane potential was measured by the JC-1 probe staining and fluorescent microscopy. The expression of an oncogene (c-Myc) and a tumor suppressor [p21 (WAF1/Cip1)] proteins was analyzed by using Western blotting. Erythromycin could inhibit the proliferation of SH-SY5Y cells in a concentration- and time-dependent manner. The cell cycle was arrested at S phase. Mitochondrial membrane potential collapsed and the cytosolic calcium was overloaded in SH-SY5Y cells when treated with erythromycin. The expression of c-Myc protein was down-regulated, while that of p21 (WAF1/Cip1) protein was up-regulated. It was concluded that erythromycin could restrain the proliferation of SH-SY5Y cells. The antitumor mechanism of erythromycin might involve regulating the expression of c-Myc and p21 (WAF1/Cip1) proteins.